<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW35</accession>
    <name>A1RW35_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751680.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0005"/>
    <dbReference type="EnsemblBacteria" id="ABL77415">
        <property type="protein sequence ID" value="ABL77415"/>
        <property type="gene ID" value="Tpen_0005"/>
    </dbReference>
    <dbReference type="GeneID" id="4601654"/>
    <dbReference type="KEGG" id="tpe:Tpen_0005"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="DMVPCEL"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="269" mass="30125" checksum="94EA1F1BD9698102" modified="2007-02-06" version="1">MIRFENVRFSYGEGLFEMRDLNVEIKRGEFVGVIGHSGAGKTTFAKLAVGLLKPRSGRVLVDGKDTRTTPVSELARKVGYVYQNPDLMIFSPTILDEVGFALRNMGYPESKVKDMVLRALESVDLSKPLDASPHMLSFGEKHRLAIASVLVTEPDVLILDEPTTGLDYARCLQLFRVLEKLYKGGKTVVVITHDLDLLGMFSTRVLVFEKGRLIRDGATEEVLLDTEFLEEKGFIPTQLQRLSKMLGLKAYSPSKIAEYIIELRKKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW62</accession>
    <name>A1RW62_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0032"/>
    <dbReference type="EnsemblBacteria" id="ABL77442">
        <property type="protein sequence ID" value="ABL77442"/>
        <property type="gene ID" value="Tpen_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0032"/>
    <dbReference type="eggNOG" id="arCOG04217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136010_0_0_2"/>
    <dbReference type="OMA" id="PHGKYVN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043998">
        <property type="entry name" value="Put_Metallopep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18894">
        <property type="entry name" value="PhageMetallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMetallopep" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="166" mass="19118" checksum="83831C1E5048D407" modified="2007-02-06" version="1">MPRIRYERARDVEELVEDIVACLGLDWIDVRRLHFVRSHGSRSKAYARIYGVPRIFQVALGLKPLYIIEVVSENFDKLGDAEKIKVLIHELMHIPRSFSGGLRPHGKYTSRQNVEKLFKEYLARKRSKNIYGTLGNRIETHGKAPRPAGKSRKAGVVKRGKTRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW99</accession>
    <name>A1RW99_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751744.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0069"/>
    <dbReference type="EnsemblBacteria" id="ABL77479">
        <property type="protein sequence ID" value="ABL77479"/>
        <property type="gene ID" value="Tpen_0069"/>
    </dbReference>
    <dbReference type="GeneID" id="4600899"/>
    <dbReference type="KEGG" id="tpe:Tpen_0069"/>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054903_0_0_2"/>
    <dbReference type="OMA" id="GGMGIEP"/>
    <dbReference type="OrthoDB" id="71077at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="35254" checksum="5A8C414CA9A67289" modified="2007-02-06" version="1">MFPETVASSVFVPYLRRVLVSELRKLNMSQTDIARLTGVTQAAVSKILREKQGSRYGSTGLDVPENEIRVVARKIAKILSQGNINEAGFLSNRYWWLIAASGDACKAHEKYGWRKSECYICTKVVYPNLDVSRGLVMADMERALIVLWSSEYFGLLIPEVLTNIAMAIPGAKSIYDVAAVPGRISRSKSGEILYRQPEFGASRHLSGILLSINGKYRAVINIKYDEIVEEALVSMGLRFKEFSSEDYPSANPAASAAAELLEECPDCKALVDVGGENVESVTYIFGNRAVEVANIAVSLSEIYYAVAVKKGKIIYSIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC7</accession>
    <name>A1RWC7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751772.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0097"/>
    <dbReference type="EnsemblBacteria" id="ABL77507">
        <property type="protein sequence ID" value="ABL77507"/>
        <property type="gene ID" value="Tpen_0097"/>
    </dbReference>
    <dbReference type="GeneID" id="4601714"/>
    <dbReference type="KEGG" id="tpe:Tpen_0097"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126379_2_0_2"/>
    <dbReference type="OMA" id="CCENTEM"/>
    <dbReference type="OrthoDB" id="85209at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="140" mass="15943" checksum="966CEBFE15ED454D" modified="2007-02-06" version="1">MRYRLTPSIVRGWLYCRVCGRCCENTEMILLEEDVERISSYTGLRAEDFAERLGGRFKLKNVNGKCVFFDAEKGSCTIYPVRPIGCSLYPVVVDEYEGLTVDEYCPLSKLVGSYEKEKAGAVLRALYPKLGLQPPPYRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD3</accession>
    <name>A1RWD3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionyl-tRNA synthetase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751778.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0103"/>
    <dbReference type="EnsemblBacteria" id="ABL77513">
        <property type="protein sequence ID" value="ABL77513"/>
        <property type="gene ID" value="Tpen_0103"/>
    </dbReference>
    <dbReference type="GeneID" id="4600865"/>
    <dbReference type="KEGG" id="tpe:Tpen_0103"/>
    <dbReference type="eggNOG" id="arCOG01136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065946_3_3_2"/>
    <dbReference type="OMA" id="CDKPVLL"/>
    <dbReference type="OrthoDB" id="109426at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="115" mass="12729" checksum="DF63E5A388D30B02" modified="2007-02-06" version="1">MGYERYCMSQITISEFQRLDIRIGRILSAEPIKRSDKLLLLKVDLGTEQRQIVAGLAPYYKPEELVGKEVAVLANLQPKTIMGFVSQGMLLAAVEDGKPVLLVPEKEVKVGAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE2</accession>
    <name>A1RWE2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase</fullName>
            <ecNumber evidence="7">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eno</name>
        <name evidence="12" type="ordered locus">Tpen_0112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell surface</location>
        </subcellularLocation>
        <text evidence="7">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0112"/>
    <dbReference type="EnsemblBacteria" id="ABL77522">
        <property type="protein sequence ID" value="ABL77522"/>
        <property type="gene ID" value="Tpen_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0112"/>
    <dbReference type="eggNOG" id="arCOG01169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_2"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="147"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL77522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="438" mass="47454" checksum="F5CC049240B61583" modified="2007-02-06" version="1">MTMRYNMEDEFSITHVKARWVLDSRGNPTVEAEVRTFAGGYGSAIVPSGASTGTHEALELRDGGKRFHGKGVSKAVENVNKIIAPEILGEDSRKQEEIDSKMISLDGTPNKSRLGANAILSVSLAVAHAAADTYGLPLFQYLGGALASTLPVPLMNIINGGKHAGNELKIQEFLIVPVGASSFSEALAIGSEVYHSLRGYLKEKYGVSAINVGDEGGFAPPMSRTREALDALIHAVKNAGYEPGRDVVLALDAAASEFYDEKRGVYAIDGAELTREKLIEFYESLVEEYPIVSIEDPLYEEDFEGFAEVTRSLKIQVVGDDLFVTNVERLRRGIEAGAANALLLKVNQIGTLTEALSAARMALENNYSVIVSHRSGETEDVTISHIAVALNAGQIKTGAPARSERNAKYNELLRIEEYLGGRARYPGIKAFKAYKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF0</accession>
    <name>A1RWF0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="2">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Spermidine synthase</fullName>
            <shortName evidence="2">SPDS</shortName>
            <shortName evidence="2">SPDSY</shortName>
            <ecNumber evidence="2">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speE</name>
        <name evidence="7" type="ordered locus">Tpen_0120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751795.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0120"/>
    <dbReference type="EnsemblBacteria" id="ABL77530">
        <property type="protein sequence ID" value="ABL77530"/>
        <property type="gene ID" value="Tpen_0120"/>
    </dbReference>
    <dbReference type="GeneID" id="4601199"/>
    <dbReference type="KEGG" id="tpe:Tpen_0120"/>
    <dbReference type="eggNOG" id="arCOG00050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_2"/>
    <dbReference type="OMA" id="YGSDEHE"/>
    <dbReference type="OrthoDB" id="77175at2157"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="2">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="304" mass="35305" checksum="80D440B045D68782" modified="2007-02-06" version="1">MAEEQGFGVLWYTEWLSSLEAHVHGIKRIIYDGRTKYQRVTLAETGSFGLTLFLDGYAQSSEYDEFVYHESLVHPAMLTHPHPEKVLVIGGGEGATLREVLKHPSVKRAVMVDIDEELVEIVKRYMWKWHRSSFDDPRVELLFMDGKKFVEETSERFDVIILDLTDPVSGTPGVHLYTKEFYETIYDKLTPQGVMVTQATSTRYNVKAFSVINNTVASVFPVARPYKVFVATFYSEWGFALGSKGRDPLKIDKEEISRRLQSLDLRYLDLETFYYLFHIPKYIREEMQKYTQISTRDNPLQIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF9</accession>
    <name>A1RWF9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0129"/>
    <dbReference type="EnsemblBacteria" id="ABL77539">
        <property type="protein sequence ID" value="ABL77539"/>
        <property type="gene ID" value="Tpen_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0129"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_9_1_2"/>
    <dbReference type="OMA" id="DVFEMND"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="83" mass="8988" checksum="4EDC1E257889429D" modified="2007-02-06" version="1">MARSMAKLKVTIDRDQCISDMACVSLCPEVFEMNEEDGKSSIVAKYRVGNNLGEGLVPGELEDCVKSAAEACPVSIIHVEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG8</accession>
    <name>A1RWG8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0138"/>
    <dbReference type="EnsemblBacteria" id="ABL77548">
        <property type="protein sequence ID" value="ABL77548"/>
        <property type="gene ID" value="Tpen_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0138"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716930_0_0_2"/>
    <dbReference type="OMA" id="CYFDNDV"/>
    <dbReference type="OrthoDB" id="61105at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="387" mass="45542" checksum="9743CE17016F9A68" modified="2007-02-06" version="1">MLFPRIYIGTSGWDYDDWLDVFYESERGMFTYYARFFNTVEINSSFYSLLGEKFYKGLAEAAPEGFVFSLKMYQGITHKRLLNPRLVEKELDFFLKSIEPLRAAGKLGAVLIQMPPRSRREIPWFNEFLDMLPSNVRFAVEFRDESWLSEDIFKRLADRNIAYTVVDEPLLPPVVRITADFGYFRWHGRGERPWYYYHYSLEELKGWASKISEVIGEVKMLLGYFNNHFRGFAPHNALQMVVLLGIANKRQREKLEEMEKYFASAPRKYERELQEALSSGDLDKALRLLAGERRFERATGISDSEVKYTLQGGVLRGTVKQYFVGVDPGGRRIVHDCEDWRKSLETKRLCKHIVKLFQVLPREYSLNVLRDFAENMDEWTFEYGRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH2</accession>
    <name>A1RWH2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
            <ecNumber evidence="5">3.1.3.6</ecNumber>
            <ecNumber evidence="5">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EC" id="3.1.3.6" evidence="5"/>
    <dbReference type="EC" id="3.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751817.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0142"/>
    <dbReference type="EnsemblBacteria" id="ABL77552">
        <property type="protein sequence ID" value="ABL77552"/>
        <property type="gene ID" value="Tpen_0142"/>
    </dbReference>
    <dbReference type="GeneID" id="4602185"/>
    <dbReference type="KEGG" id="tpe:Tpen_0142"/>
    <dbReference type="eggNOG" id="arCOG02303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_3_2"/>
    <dbReference type="OrthoDB" id="110625at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="4">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="251" mass="27087" checksum="94E5615F279F0960" modified="2007-02-06" version="1">MRILVVNDDGVGDGLLALARVAERLGHSVFLATTHDQRSGYSKSVSFKATYTPAKIGGYEGIVTNSSPASAVLLAFKVFGKEFDFVLSGVNMGPNLGLWDILSSGTVGAVLEAALHGVPGAAVSLVAGSHEEYSSLTYEDYERAARLAVDLLERLEWRPPCEVLNINVPLRTNGSVKFTLPERVPPRDLYRCSGNECRMGYWTLQESYVCSNPRSDVCAIKEGFVSVTPLSPGSLAREDLVKKLTRSTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH7</accession>
    <name>A1RWH7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0147"/>
    <dbReference type="EnsemblBacteria" id="ABL77557">
        <property type="protein sequence ID" value="ABL77557"/>
        <property type="gene ID" value="Tpen_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0147"/>
    <dbReference type="eggNOG" id="arCOG00749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OMA" id="GFVKGMN"/>
    <dbReference type="OrthoDB" id="34606at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="272"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="474" mass="52866" checksum="CFDABAE1E8F7CF7F" modified="2007-02-06" version="1">MSSRPVSGIKATLKELLTYKSGVLGLAILAFLVAFSIYAVVTIPYDQAIKLWRGSEDIWIENPRAVPPEWWEIFVGRKLPRTIKLDSRIQTFGVSKAVTPIAGTDMKLVSISFMFDYQYDDYPSELNIFFHAKYTKDPPIVKITIQRPDGLTLEIPRFSLRAPNDSLYYSISEEVRKALALYAATKYGANVSDLLDQLELTFGKYSREGLEKGNLPVEKGIYRMNIEATCFGEDSDLEAKVVIYGQVYGPAGTDNLRRPLEIALLWGAPVALAFGLTASLVTSMLQMIIATIGAWYGGVVDSVIQRITEVYMILPFLPFLIIIAAFYKVDIWVILTVVIVLSIFGAGIKSTRALVLSIKEYPYIEAAKAYGASDWRIIFLYIIPKIIPPIVPGLIGAVPGYVFLEAALSFLGLGDPFLPTWGKVLNDAYNGGALYRGYYYWVLEPSILLMLTAFAFAFLGFALDRIVNPRLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK7</accession>
    <name>A1RWK7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751852.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77587">
        <property type="protein sequence ID" value="ABL77587"/>
        <property type="gene ID" value="Tpen_0177"/>
    </dbReference>
    <dbReference type="GeneID" id="4600879"/>
    <dbReference type="KEGG" id="tpe:Tpen_0177"/>
    <dbReference type="eggNOG" id="arCOG01518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_2"/>
    <dbReference type="OMA" id="MHTPVEM"/>
    <dbReference type="OrthoDB" id="27966at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="339" mass="35688" checksum="546D10B00EDDCEF0" modified="2007-02-06" version="1">MVETSLLSKLANAPAPSGFENRVREIIAEELEELGYEPVTDSLGNLYVVLGEGRPSLVLAAHMDEVGFIVTHVTEDGFLRVAPLGGVVAEGLPGQEVVVLTDEGLVEGVIGATPPHLRGATQKELTVEEIFIDIGVLSREEARSKGVDVGSPVTFAGNFKERGDAVISKALDDRVGCYALLEALRSGATPKKGSVVVAFTVQEEVGLRGSSALAKALEPNFAVAVEGTIANDTPGTPPEKVVTRLGRGPAVRLMDKSMIASMELYKHIKALAESKSIPYQVQISPYSGTDAGSFAVHGAAVSAVSVPVRYIHSPASLALKKDVDATVELLKALIEEPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK9</accession>
    <name>A1RWK9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751854.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0179"/>
    <dbReference type="EnsemblBacteria" id="ABL77589">
        <property type="protein sequence ID" value="ABL77589"/>
        <property type="gene ID" value="Tpen_0179"/>
    </dbReference>
    <dbReference type="GeneID" id="4600881"/>
    <dbReference type="KEGG" id="tpe:Tpen_0179"/>
    <dbReference type="eggNOG" id="arCOG12282">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056181_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="119" mass="13575" checksum="17AD093504189066" modified="2007-02-06" version="1">MSVQVVEVYVFVERSALLDEKSFTAIDDFMIKVLHEESMYDVLEKAGELPLDRVKLLLREEDLRKLTAYGELALRGEASRKILETLQWSDASGEGYVVLVLKKQNDGGFFNECPSRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL9</accession>
    <name>A1RWL9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0189"/>
    <dbReference type="EnsemblBacteria" id="ABL77599">
        <property type="protein sequence ID" value="ABL77599"/>
        <property type="gene ID" value="Tpen_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0189"/>
    <dbReference type="eggNOG" id="arCOG01500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_3_2"/>
    <dbReference type="OMA" id="KACSKRC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="180" mass="19579" checksum="5E70D8A11B68C300" modified="2007-02-06" version="1">MAAGRNPVVEEKDPAIEKLVCIYPERCIGCRACEVACEIEHGGKSFIDVYLIEEARMCVPLNCRHCEEAPCMAVCPVKAIKRDAEGAVIVDSLRCIGCRLCVLACPFGIPTVDKELKIMVKCDMCAERRARGLEPACVATCPADALVYESVEEYQRAKRAATALKIAGSGRESEIKGIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN2</accession>
    <name>A1RWN2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0202"/>
    <dbReference type="EnsemblBacteria" id="ABL77612">
        <property type="protein sequence ID" value="ABL77612"/>
        <property type="gene ID" value="Tpen_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0202"/>
    <dbReference type="eggNOG" id="arCOG01121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168734_0_0_2"/>
    <dbReference type="OrthoDB" id="123312at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="125" mass="14316" checksum="486E2EB843BB4F2E" modified="2007-02-06" version="1">MLKVLILALFKRSVMTTDKIMEGGSATPQKAFEKMVNKAAWLLSEGRVVKISPYLYYVIGKNSKHLVRYENGRFICTCKGFEEKGVCSHVIAVATLSELKDVNAFLDERVKERVRRELRELYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP3</accession>
    <name>A1RWP3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase, subunit M</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0213"/>
    <dbReference type="EnsemblBacteria" id="ABL77623">
        <property type="protein sequence ID" value="ABL77623"/>
        <property type="gene ID" value="Tpen_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0213"/>
    <dbReference type="eggNOG" id="arCOG00580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166550_0_0_2"/>
    <dbReference type="OMA" id="EYDQEEM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOL9" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10729" checksum="D880D0760212231E" modified="2007-02-06" version="1">MEFCPKCGGLMLPKKIKRSTYLVCQSCGYMVKAKKAETAGYSMRESISEDKRTKVSVFDVKSVTQAEEERAQAKEEYYEVFLETYAEEETEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP6</accession>
    <name>A1RWP6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0216"/>
    <dbReference type="EnsemblBacteria" id="ABL77626">
        <property type="protein sequence ID" value="ABL77626"/>
        <property type="gene ID" value="Tpen_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0216"/>
    <dbReference type="eggNOG" id="arCOG04309">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_0_0_2"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="263" mass="29178" checksum="9219A59682C734C5" modified="2007-02-06" version="1">MDSARIIAFLSDFGTRDYYVGAVKAVVHSLCPQSTVVDVTHEVEPWSVEDACYILRCCYDDFPSRTVFLVVVDPGVGTSRKAIILEHKGYLFVGPDNGLLPCAVGNKEFKAWEILRVPGARRKTSHTFHGRDVFAPVAAFLSCGGRPEEIGREYADPVLMDIEETILEEGWVKARVIHVDRFGNVALGVRPEKFFREYGPTRIRVAFDDHEVDVPFVRTFGDAPRGSLVALVNSCGYLELAVNMGNASEVLGLKPGRIVKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT4</accession>
    <name>A1RWT4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751929.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0254"/>
    <dbReference type="EnsemblBacteria" id="ABL77664">
        <property type="protein sequence ID" value="ABL77664"/>
        <property type="gene ID" value="Tpen_0254"/>
    </dbReference>
    <dbReference type="GeneID" id="4601846"/>
    <dbReference type="KEGG" id="tpe:Tpen_0254"/>
    <dbReference type="eggNOG" id="arCOG02603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044529_0_0_2"/>
    <dbReference type="OrthoDB" id="111541at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="125" mass="13349" checksum="DD42D3E29B31CCD1" modified="2007-02-06" version="1">MSLDLESLRKIIDPVTRVAGVEGFVISSSDGLPLFSSLTDKDLEEKVAALTAVLSEVGNRASTELGKGEAEWITVNAPDGSGIIYTKLGEIGYMAVLFGKDTRLGVLLYTLKDIKRRIAEAAGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU1</accession>
    <name>A1RWU1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751936.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77671">
        <property type="protein sequence ID" value="ABL77671"/>
        <property type="gene ID" value="Tpen_0261"/>
    </dbReference>
    <dbReference type="GeneID" id="4601678"/>
    <dbReference type="KEGG" id="tpe:Tpen_0261"/>
    <dbReference type="HOGENOM" id="CLU_2597936_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="79" mass="8625" checksum="411F805FC303EF6C" modified="2007-02-06" version="1">MNPAAQDDNDPQKPGRGRTGEEGAEAQAKTRPWGETLPLPAAKNIFFYPLVYPSLPSMGALPERERSDERARLGFARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX9</accession>
    <name>A1RWX9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751974.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0299"/>
    <dbReference type="EnsemblBacteria" id="ABL77709">
        <property type="protein sequence ID" value="ABL77709"/>
        <property type="gene ID" value="Tpen_0299"/>
    </dbReference>
    <dbReference type="GeneID" id="4601119"/>
    <dbReference type="KEGG" id="tpe:Tpen_0299"/>
    <dbReference type="eggNOG" id="arCOG04283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204008_0_0_2"/>
    <dbReference type="OMA" id="DDLGMSW"/>
    <dbReference type="OrthoDB" id="119951at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="11222" checksum="133B79E01B8CD291" modified="2007-02-06" version="1">MGKPVKVIYVGADWAPFNDKLKRLCQEFAASKGLAFEERNEDFVFLTKYGEKDELGGADIPQVFIGYDDGTVKHVLTKVPIAGASPDFEEARKRLEKALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX09</accession>
    <name>A1RX09_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Tpen_0330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752004.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0330"/>
    <dbReference type="EnsemblBacteria" id="ABL77739">
        <property type="protein sequence ID" value="ABL77739"/>
        <property type="gene ID" value="Tpen_0330"/>
    </dbReference>
    <dbReference type="GeneID" id="4600981"/>
    <dbReference type="KEGG" id="tpe:Tpen_0330"/>
    <dbReference type="eggNOG" id="arCOG04120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_2"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="40634at2157"/>
    <dbReference type="BRENDA" id="2.7.1.40">
        <property type="organism ID" value="11662"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="349"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABL77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="464" mass="51359" checksum="813889D2553A412D" modified="2007-02-06" version="1">MAKVKLVATLGPSSWSEETMKRMVAEGVNAFRLNFSHVDYARFEELAKQVRRLETPLRPLTLIADLQGPVIRLGEFAPFQVRPGDRVTFTLSSKTEEKYAVPVPNGVFFEIVREGDEVLVEGGRLAFRIVDAGPEKAVGEALLEGEVKPRKTVTVRGKDIPLPTITEKDLRDIEFSVKAGFDAIALSFVRSSSDVQRLRDILFDYGAEDVKIIAKIETKSAVEDLDSILQKSDAALVARGDLANFYGLEEIYSIQRYIISRARRFGKPSIVATQLLESMISNPLPTRSEVVDVITAVRMGADALLLAGETAAGKYPVESVYWLRRIVEEAEREPLEVEDVAPDKSDLYESIAKGVVSLAEVISGKIIAFSEKGNTARRISKFRPKAGLIVFTNDPATARYVNMIYGVRVVYDPSLSKADQNLFSKMLSKALEHNLVNLGDLVVFTSGRRRGSTDLVSVERVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX22</accession>
    <name>A1RX22_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752017.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0343"/>
    <dbReference type="EnsemblBacteria" id="ABL77752">
        <property type="protein sequence ID" value="ABL77752"/>
        <property type="gene ID" value="Tpen_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="4601453"/>
    <dbReference type="KEGG" id="tpe:Tpen_0343"/>
    <dbReference type="eggNOG" id="arCOG02169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757839_0_0_2"/>
    <dbReference type="OrthoDB" id="133738at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="154"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="38855" checksum="BF795E41FF0E2D37" modified="2007-02-06" version="1">MYRKSIAVLFVVSALGGLTLWNSSDYILVTTYVAKGGAGTVPIDVFSRNLLLAPSIQGYQERLSAELYINSRPVNFTVKVDNEGNEYPYVGEIAYTGFINVTLVQRVRVYAVHSRSYFGVPASSSWPATRAGSLPRNSFWRCNTSAVGLRDLRSISNRLAANASGPVDFAYKVARWALSEAKYEESYGGISCPSAFLKEKKGACGDFSAFIAALLKIQGLNAYLVYSLVEDQGAYLNVSTARSSFLIKGAYPHVFTVLEVDGYRVPIDATANVGGDPIRGAVALNRDGVVILYKVVNSDPNDYLILYAPGNDAQVYYSIVVKRNQGTIDAGFGWSILGVAVAIVLVLGKRLDASDDRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX38</accession>
    <name>SRP19_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Signal recognition particle 19 kDa protein</fullName>
            <shortName evidence="1">SRP19</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">srp19</name>
        <name type="ordered locus">Tpen_0359</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752033.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX38"/>
    <dbReference type="SMR" id="A1RX38"/>
    <dbReference type="STRING" id="368408.Tpen_0359"/>
    <dbReference type="EnsemblBacteria" id="ABL77768">
        <property type="protein sequence ID" value="ABL77768"/>
        <property type="gene ID" value="Tpen_0359"/>
    </dbReference>
    <dbReference type="GeneID" id="4600897"/>
    <dbReference type="KEGG" id="tpe:Tpen_0359"/>
    <dbReference type="eggNOG" id="arCOG01217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="OMA" id="VIWPAYL"/>
    <dbReference type="OrthoDB" id="121943at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="PTHR17453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0733">Signal recognition particle</keyword>
    <feature type="chain" id="PRO_0000300754" description="Signal recognition particle 19 kDa protein">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00305"/>
        </source>
    </evidence>
    <sequence length="101" mass="11940" checksum="29B4E7EEB693D078" modified="2007-02-06" version="1">MLKKNGFIVWPVYFDSTKPRKWRRVPRKLAVEKPTLSEIVEAVKREGFSFTVEENAKHPAYWYEVQGRVIVQANVKKSVLLKKIAENLQKIRAEQSSKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX64</accession>
    <name>A1RX64_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Initiation factor 2B related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752059.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0385"/>
    <dbReference type="EnsemblBacteria" id="ABL77794">
        <property type="protein sequence ID" value="ABL77794"/>
        <property type="gene ID" value="Tpen_0385"/>
    </dbReference>
    <dbReference type="GeneID" id="4602153"/>
    <dbReference type="KEGG" id="tpe:Tpen_0385"/>
    <dbReference type="eggNOG" id="arCOG01124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_1_2"/>
    <dbReference type="OMA" id="ARFFMKN"/>
    <dbReference type="OrthoDB" id="36100at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="35724" checksum="AEC6FA8265334717" modified="2007-02-06" version="1">MFEEELEKISSGKIYSSTETVIYALDLLNTVVKQKDPSLFIEVTEKILRSRVTSAMLQNIMRIILGELVAAQPRSFVELGEAFQKQYERATSRLREDVERSASIASRRISNGDVLLTNSYSLFVKKTIEKALRDGKELKVYVTESRPTGEGVRFAAELADMGVDTYLIVDSAARFFMKEVDKVLFSSEAISANGAVVNKVGTSLIALAAHEARVRVYVVSSTLKFSPETIIGELVEIPEIEFTEYIPSGWENLRKLKPRSPLFDVTPPSYIDAIITEKGVIAPEFSIVMLRESFGWPLKVEKVENLLSRLKNMLVGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX69</accession>
    <name>A1RX69_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752064.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0390"/>
    <dbReference type="EnsemblBacteria" id="ABL77799">
        <property type="protein sequence ID" value="ABL77799"/>
        <property type="gene ID" value="Tpen_0390"/>
    </dbReference>
    <dbReference type="GeneID" id="4600525"/>
    <dbReference type="KEGG" id="tpe:Tpen_0390"/>
    <dbReference type="eggNOG" id="arCOG04209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OMA" id="KYMQELY"/>
    <dbReference type="OrthoDB" id="85023at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_L15e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="187" mass="21857" checksum="9B5008DC5208BD95" modified="2007-02-06" version="1">MGYYKYMAEIWKRPFKGEHGQLMRERFMLWRREPTVVRIPRPTRINRARALGYKAKQGYIVARVRVRKGGLNRPRPSSGRRPKRMGVYGYSPHKSAQQIAEERAARKFPNLVVLGSYYVGEDGVYKWYEVVMVDPHHPAVKRDIERRWVAGFKKKAGVKVTRDLLLKILSKAKLDVSENAGEKEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX77</accession>
    <name>A1RX77_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid binding, OB-fold, tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752072.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0398"/>
    <dbReference type="EnsemblBacteria" id="ABL77807">
        <property type="protein sequence ID" value="ABL77807"/>
        <property type="gene ID" value="Tpen_0398"/>
    </dbReference>
    <dbReference type="GeneID" id="4602110"/>
    <dbReference type="KEGG" id="tpe:Tpen_0398"/>
    <dbReference type="HOGENOM" id="CLU_1691627_0_0_2"/>
    <dbReference type="OrthoDB" id="138752at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="1">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="18719" checksum="060F0D754537930A" modified="2007-02-06" version="1">MGEGREGYEILLDCFLKALPSEVVAGAVKRGSVVYFRVVHGKAVLMSRKIAVVGRVQGVVHGDKFTDIVLGDGSGTVTVRFWSEKKGLLEDKGLAEGSTAKVLGVLRESREGTVYVTPIAVQSVPDGYLEEFTARIREDRDFLATFIEKQRSTVDAEEATPPIGRDFSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX79</accession>
    <name>A1RX79_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752074.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77809">
        <property type="protein sequence ID" value="ABL77809"/>
        <property type="gene ID" value="Tpen_0400"/>
    </dbReference>
    <dbReference type="GeneID" id="4602113"/>
    <dbReference type="KEGG" id="tpe:Tpen_0400"/>
    <dbReference type="eggNOG" id="arCOG05523">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103642_0_0_2"/>
    <dbReference type="OrthoDB" id="131644at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="108" mass="12367" checksum="85EC096559154321" modified="2007-02-06" version="1">MAEKSRRKKKGEEEKPPAVDLTSFLSPQSEERAAPRVQAFFTEDVERMIVEEVTRSSGGVTRSELYKRVTGRGVKPVEFYRALTNLLGKGVLKRRFSPELEEYVIYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX80</accession>
    <name>A1RX80_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal-transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0401"/>
    <dbReference type="EnsemblBacteria" id="ABL77810">
        <property type="protein sequence ID" value="ABL77810"/>
        <property type="gene ID" value="Tpen_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0401"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_0_0_2"/>
    <dbReference type="OMA" id="GSDWAFN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="228"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="302" mass="33667" checksum="1138F5415AE44A97" modified="2007-02-06" version="1">MVMRVSELPVGRFPPLAVVPSSSRVLDVLVAMGRNRVRHVPLVDERGVLKGMVSARDLVDFLGGRRFRDVVEARFNGDVYKALEQTGVEFLKYDPPYVYTRSDLREVIELMVERGIGALAVVDEDLRVVGIVSERHVISLLANVETHVKVKEIMTSEVVYLSPMDSLFEGMRVMSERRIRRLPLVSGEELRGIVTIKDVLSYVSREDVLARLKEGSRSAVYDTPLVYISSKPVLAVEDDVDVGLAVSLMKKHGIGALVVTHDGKPRGIVTERDVLTRLPRVKGVEIFLDEATKTIFGGRVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB5</accession>
    <name>A1RXB5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0436"/>
    <dbReference type="EnsemblBacteria" id="ABL77845">
        <property type="protein sequence ID" value="ABL77845"/>
        <property type="gene ID" value="Tpen_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0436"/>
    <dbReference type="HOGENOM" id="CLU_2447826_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="89" mass="10030" checksum="2774025AE42D57B2" modified="2007-02-06" version="1">MSGVMKVGIRLELPAEEEEYRSISVDDYSGGGIVILHAFSRGRIIYAVETDQRKFSLARSIVNEVLRLYSMLEGVKEELPQTQGKREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD2</accession>
    <name>A1RXD2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0453"/>
    <dbReference type="EnsemblBacteria" id="ABL77862">
        <property type="protein sequence ID" value="ABL77862"/>
        <property type="gene ID" value="Tpen_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0453"/>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_2"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="100186at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="241" mass="27203" checksum="6F29ABD29CE7606A" modified="2007-02-06" version="1">MRAFPRDAVERLERWLGFRAEGVLGFGAEAVIVKGELAGEKVVVKYRVPKSYRDPRLDSELRRERTVLESRILSRAAMAGVNVPVPVLVYPEEGILVMTYIGGERLKDSMRGIEPGTLRNVFVEIGRQLGTLHSLGIVYGDLTTSNVILSPTRTPWLVDFGLGFFSNRDEDAGVDLHLFKRALESTHPLQAEDLFQAFVDGYAQIRGRETAEKILAKMREIRLRGRYVKERRARLSRAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN5</accession>
    <name>A1RXN5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0559"/>
    <dbReference type="EnsemblBacteria" id="ABL77965">
        <property type="protein sequence ID" value="ABL77965"/>
        <property type="gene ID" value="Tpen_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0559"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="472" mass="54159" checksum="F5206B52C257A903" modified="2007-02-06" version="1">MGREMMGYGTVAGGVEEFDEEFVRGKLKELLEKALFPRGNYRGLKATHEQVARELAEIKANYAQYGEAYVEYVGRLGEGEEKAFREAEKAMREALKRVDELKIKRTGKTRWKAKLSGAKWRLYVHLKQSGYWSVEVRLYIRVAKLRLPDTLRIPPELLRVAQEGWVLGDASYDADRGEVKMSTSQSWQVASFPGFWPEKDVTICVKSVVINETRVSVTWYVVVKGVRDAPRLWSLPKVVKQRIILKEIGGANEGKVDIVRALKLALLYAADGEYPGPNSAKHVLEFAVGRRSRQVRTGGSVRIARLLYKEVPQLLAYMVASGCKKAEFLASLAFVEPRPYRLSLRYLEVAGVRMNLQLVGNKNYYTLAARVYITEDNEEMLRDFPERARKEGLVVKKMKIAKKYYCYYAGMRELTGYCDKHPEAYNTLIDFVQEELETMPLDHPARRSVERLLERLRKARERALKKLGARQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP4</accession>
    <name>A1RXP4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752239.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77974">
        <property type="protein sequence ID" value="ABL77974"/>
        <property type="gene ID" value="Tpen_0569"/>
    </dbReference>
    <dbReference type="GeneID" id="4600613"/>
    <dbReference type="KEGG" id="tpe:Tpen_0569"/>
    <dbReference type="eggNOG" id="arCOG15102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565930_0_0_2"/>
    <dbReference type="OrthoDB" id="126834at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="8686" checksum="D5E6BF79D4869221" modified="2007-02-06" version="1">MINKNDVEKKARSLFRDAQIEVKMEGKGIKLAIEGIGEDVGELFTKIGDLVSGIAKASGAKDTDVIVSIQGSAYGIEIEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR4</accession>
    <name>A1RXR4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0589"/>
    <dbReference type="EnsemblBacteria" id="ABL77994">
        <property type="protein sequence ID" value="ABL77994"/>
        <property type="gene ID" value="Tpen_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0589"/>
    <dbReference type="eggNOG" id="arCOG04429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1458244_0_0_2"/>
    <dbReference type="OMA" id="EWIEENC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="182" mass="19856" checksum="6B830826FC13D8BD" modified="2007-02-06" version="1">MNASPRILIMGVGNRMYGDDAFGPLFAEALEQCGVPALNSELDVFTAVSHLEGVDLLIFIDVVDKSFGEPGDVVVLRIDPRTLSPEEVATAISFETSAHQVTPAHIVLLGYSSGFFRGEAYVVGVVSEHTDFARKMSSRVVAAAERACLKLREIARSAEINCVCVQKEFRNIVARYSQEFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY5</accession>
    <name>A1RXY5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0663"/>
    <dbReference type="EnsemblBacteria" id="ABL78065">
        <property type="protein sequence ID" value="ABL78065"/>
        <property type="gene ID" value="Tpen_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0663"/>
    <dbReference type="eggNOG" id="arCOG03770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140808_0_0_2"/>
    <dbReference type="OrthoDB" id="130362at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="17966" checksum="C487EE4DB7789504" modified="2007-02-06" version="1">MLRTSSVDEMIAQLKRKWIPIYLALLLATLGVTIALLRLWISTNNEQYFSAALLSLMLSSYISWYLVKVLRVKQTPRQLLTLVRCETCGYEEARLYTEGDALFQAKGTCPKCGKGDLVVVGIYLRVPVQVGEQQPNILSRAARFIMLIRRRRGACRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY7</accession>
    <name>A1RXY7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752332.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0665"/>
    <dbReference type="EnsemblBacteria" id="ABL78067">
        <property type="protein sequence ID" value="ABL78067"/>
        <property type="gene ID" value="Tpen_0665"/>
    </dbReference>
    <dbReference type="GeneID" id="4601623"/>
    <dbReference type="KEGG" id="tpe:Tpen_0665"/>
    <dbReference type="eggNOG" id="arCOG00073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026622_0_0_2"/>
    <dbReference type="OMA" id="RWCCKVT"/>
    <dbReference type="OrthoDB" id="6490at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="614" mass="70741" checksum="255D78986081FED9" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY22</accession>
    <name>A1RY22_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0700"/>
    <dbReference type="EnsemblBacteria" id="ABL78102">
        <property type="protein sequence ID" value="ABL78102"/>
        <property type="gene ID" value="Tpen_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0700"/>
    <dbReference type="eggNOG" id="arCOG00047">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738932_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="374" mass="41331" checksum="72059F7CAACA8DFA" modified="2007-02-06" version="1">MFLEKFNVSYPNEPRVFAVYTTWCVSRCNFYETLEALESTGEARVLGSLGDRLVFLAARSLEGIVERLYSVACVEELYFVLGEARLGERPLLEGDMLSRVSHLLLHATTFNVKILDCEKMLGVEEKAKLREDFSKILKELREGLRASRTGPDLEFVVIVLSRDRALLSLTVKRYRKDRFAFRSPERRAYSQPSALTPWLSLTILNLALATQPAGGEGGFDVAFLDPFCGTGGVLIEAALQGMYSVGVDVNYRQVRGSKKNLSVLGLRAVADLVLCDSTKLPFRAEAFNAAAFDPPYGRLAPTHGRDPGEILRGALRNVVESVKPRGRIAFFASDMLLQNVDAPALCDVYEHSSLTRHVIVVRRTNHAAGGPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY40</accession>
    <name>A1RY40_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752385.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0718"/>
    <dbReference type="EnsemblBacteria" id="ABL78120">
        <property type="protein sequence ID" value="ABL78120"/>
        <property type="gene ID" value="Tpen_0718"/>
    </dbReference>
    <dbReference type="GeneID" id="4601483"/>
    <dbReference type="KEGG" id="tpe:Tpen_0718"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_0_2"/>
    <dbReference type="OMA" id="SLCDPFL"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="387" mass="41986" checksum="1F42DF813F5BD0C6" modified="2007-02-06" version="1">MQYDAAVVGAGPAGLMFARVLASKGFRVAVLEKNETLAVKPCGEGISARVLQTAEINRSDTQRFVSHAIKGAVVVAPNGRKVVIKEEGELGYVIDKRNFLRVMGEYAASYGADIYMKEPVKEVVFKNGHWTVRARTVELEARLLVGADGYLSYTAKALGLEKPGERRVIPTVQYVMPNVELEDPDMTYFFLGNEVAPKGYVWIFPKDGRLANVGIGVQGASPKAYLDKFIKNNPSIFGKARILEFRGAAVTIGGMLSEIVSEHAMLVGEAAGQVIPLTGGGIHTSIAGGKIAAEVASKALAEGDLSKKRLEEYKKLYNEYWGKRIRDSLKGLHAIEKMSDEELNQLAEILSPQDVVNLANGENVASVALKLLKHPIFSIKLAKALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY43</accession>
    <name>A1RY43_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752388.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0721"/>
    <dbReference type="EnsemblBacteria" id="ABL78123">
        <property type="protein sequence ID" value="ABL78123"/>
        <property type="gene ID" value="Tpen_0721"/>
    </dbReference>
    <dbReference type="GeneID" id="4601486"/>
    <dbReference type="KEGG" id="tpe:Tpen_0721"/>
    <dbReference type="HOGENOM" id="CLU_775275_0_0_2"/>
    <dbReference type="OrthoDB" id="118936at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="354" mass="39254" checksum="CC3C4436FD0D1311" modified="2007-02-06" version="1">MRRRLAGLLIAAGFFFMQGGEAKTYGALLIASGLLLVYPEVFAVAKVFVHGGFPLPPLLTEENYCRAKVGRFVCLYAGFEVVDCRHGVYDMVERGFWFSASRLLTLALAGNADYYLVVRSGSYYLLVRGCDERLEGAVEVVASSLERVRRALAVSGCSFRALSGREVYSLLRPDFLREVRGGLFRRVLAFTGGVVALWKLPFLAPASLALLLASLPDGMRGYSVPKGREVFSLDSVTSFYTYTSMSDVFSRAQLVYSLADSVLLVLRVKRADAELERSIDTQAYRTYEFGTAFDKLSWIHESSKFFAAARRRWEREEALYLVEGLLVAPADTARTLAAAGFSFRKSLFSLGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY49</accession>
    <name>A1RY49_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752394.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0727"/>
    <dbReference type="EnsemblBacteria" id="ABL78129">
        <property type="protein sequence ID" value="ABL78129"/>
        <property type="gene ID" value="Tpen_0727"/>
    </dbReference>
    <dbReference type="GeneID" id="4600847"/>
    <dbReference type="KEGG" id="tpe:Tpen_0727"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720845_0_0_2"/>
    <dbReference type="OrthoDB" id="74107at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="174"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="392" mass="43103" checksum="62C7D3F9D941F623" modified="2007-02-06" version="1">MRLPRLFRGNAKREEELVSVSEALPPDARLVDKNEFGALFIKNDTLLVLPFRRHEVWGAFAPIFTSSKVEEAWIFEGRGVVTLRGVGRVSFPADSVPDSLEELVTRIIAASGVNVSLRNPRGVADIGEWRVAIQVQSGGQLHLVATRVTSVPPLEEVVPPLLATRLVLLLVRPSTVVITGPPGSGKTTVLSALVKAVADFFPWLHIAIVEKYRELSFRGGWFTQVVSENLAEGVRYAMRYLRPDLLVVGEILAEDFWSLLEPTRAGIPTVTTFHAPSAQRALKSLSDALRVHLGGATNVLNYLDVLVVTSKVITSSGVSRGVSAVYLSDGQRLVPVYLEGEHAEEDLFKKALPDKLYVGDLVNVEKTLRERFRPDEAQASFLKELAALSLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY61</accession>
    <name>A1RY61_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Tpen_0739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752406.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0739"/>
    <dbReference type="EnsemblBacteria" id="ABL78141">
        <property type="protein sequence ID" value="ABL78141"/>
        <property type="gene ID" value="Tpen_0739"/>
    </dbReference>
    <dbReference type="GeneID" id="4601146"/>
    <dbReference type="KEGG" id="tpe:Tpen_0739"/>
    <dbReference type="eggNOG" id="arCOG01181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_1_0_2"/>
    <dbReference type="OMA" id="GYTNFRE"/>
    <dbReference type="OrthoDB" id="74143at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="12">
        <location>
            <begin position="66"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="301" mass="33344" checksum="952B6E6BE9408CC8" modified="2007-02-06" version="1">MSVRFAVEALKVLRLDDYRLLVAVERGMINHEYVDVELVASISGLDADYAAERLKRLNGLGLVQRYRGPFTGYILTTRGYDALALYVLVKRGTLSELSTSPQGEGKESEVYLGKTPGGRVVAVKFHRAGRTSFRKTKRVRGYAADKRHVSWLYQARLAAKSEFEALRILWKGGVSVPEPVDWNRHVVVAGYVEGVELYTLPELGDPEGFLAAAVGEVGKAYEAGVVHGDLSEYNVLVAEGEKPVLIDWPQWVPSSHPSAGFYLRRDLERLASFFSRKYGVPAERAKRLVESVLAKHGAPAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE4</accession>
    <name>GYAR_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxylate reductase</fullName>
            <ecNumber evidence="1">1.1.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyaR</name>
        <name type="ordered locus">Tpen_0823</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycolate + NAD(+) = glyoxylate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.26" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYE4"/>
    <dbReference type="SMR" id="A1RYE4"/>
    <dbReference type="STRING" id="368408.Tpen_0823"/>
    <dbReference type="EnsemblBacteria" id="ABL78224">
        <property type="protein sequence ID" value="ABL78224"/>
        <property type="gene ID" value="Tpen_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0823"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00776">
        <property type="entry name" value="GyaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023519">
        <property type="entry name" value="Glyoxylate_reductase_GyaR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000348416" description="Glyoxylate reductase">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00776"/>
        </source>
    </evidence>
    <sequence length="339" mass="37993" checksum="83C1C68D2F9A7E5C" modified="2007-02-06" version="1">MARPKVYVTRIIPEPGLSMLKECCDVVVHESKDWPPSREELLRNIRDKDALLCLLTDKIDAEVMDAAPNLKVISTYSVGFDHIDIPEATKRGIYVTHTPGVLTDAVAEFTVGLILAVTRRIVEADKIIRTGQWDKPWNPYFLTGPELKGKTIGLVGLGRIGVATAKRLSSFDVKILYYDIERRWDVETVIPNMEFTDLDTLLEKSDIVSIHVPLTKETYHLINEERLRKMKKTAYLINTARGPVVDTEALVKALKEGWIAGAALDVFEQEPLPPNHPLTKFDNVVLAPHIASATIEARQRMAELAARNLIAVLKGEMPPALVNKEVLKVRPLEKVKMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE8</accession>
    <name>A1RYE8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752493.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0827"/>
    <dbReference type="EnsemblBacteria" id="ABL78228">
        <property type="protein sequence ID" value="ABL78228"/>
        <property type="gene ID" value="Tpen_0827"/>
    </dbReference>
    <dbReference type="GeneID" id="4601830"/>
    <dbReference type="KEGG" id="tpe:Tpen_0827"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_2_2"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="388" mass="42020" checksum="517453FC8D2A5496" modified="2007-02-06" version="1">MIKTAVVLAGGKGVRLRPLTLTTPKPLLPVGNVPILDHILSLLYRHGFEKVIVAVNYLGEKIVNHLVARWMDKGLEIVAPPLNPADTADAVRKCASYIDEDFLVTMGDVVTNMDLRSFAYFHESSGSIASIALIEVQSLRDFGAVLLDGNGAVLHFLEKPGVQEMYVASLAFAFTGTSRKVNLFANLANSGFYAFRYDILDVLRENPHLMDFGKNVFPWLLENNYRVKGWLAEETYWIDVGRPESYLTANFDLLAGHASPLRPYGRFVDGVYVGEGVEVSPGARIIPPVALGDNVRISQNAEVGPYAVIGSDTHIGVEAHVSYSVLMGEDTVERGAHVRYSVLAKSIKVGEGAVVRENSVLGEGVVVKEGSIVGPGTRIGGGIEVMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI5</accession>
    <name>A1RYI5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752530.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0864"/>
    <dbReference type="EnsemblBacteria" id="ABL78265">
        <property type="protein sequence ID" value="ABL78265"/>
        <property type="gene ID" value="Tpen_0864"/>
    </dbReference>
    <dbReference type="GeneID" id="4602207"/>
    <dbReference type="KEGG" id="tpe:Tpen_0864"/>
    <dbReference type="eggNOG" id="arCOG04064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042134_1_0_2"/>
    <dbReference type="OMA" id="TIPLWYG"/>
    <dbReference type="OrthoDB" id="94875at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="380" mass="40434" checksum="FE5AD2ABB3288522" modified="2007-02-06" version="1">MEAGSLFALLVAAGLYMLVYLVLRARSGVAGTWLELQGGVVVLKTRRLNRLVEDVGKKYKRLMGLVGDLGVVTGIALGAYGVFFLHDNLFKLLTASPGASPVSPLVPGVTVGLNELAYFLLAVAVTLIPHELSHAFQAAAEGVRIKSMGVFLAFLVPGGFAEIDEDELDSKPLRSKLRVLAAGSFANIATFLLLVALFYLVLFTPLAPRPNGVLVSGVIQGSPAFQRLQPGDVIVAVNGTPTPTLEGFSKVMERSAPGRLIKLTVMRGSVLVNYSLVLAQHPESPGRGFIGVKIDQSYSNEWLYRAFWWMLVVTSSVAIINMLPIVPLDGGKLLSYLLQAVAPGRASKVAVWACSAYMLIVLLASMATSAGVFGLAPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ8</accession>
    <name>A1RYJ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ERCC4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752543.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0877"/>
    <dbReference type="EnsemblBacteria" id="ABL78278">
        <property type="protein sequence ID" value="ABL78278"/>
        <property type="gene ID" value="Tpen_0877"/>
    </dbReference>
    <dbReference type="GeneID" id="4600359"/>
    <dbReference type="KEGG" id="tpe:Tpen_0877"/>
    <dbReference type="eggNOG" id="arCOG04206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101253_0_0_2"/>
    <dbReference type="OMA" id="IIEGDLW"/>
    <dbReference type="OrthoDB" id="72352at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="3">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="246" mass="27580" checksum="4B031DBA57FFD24B" modified="2007-02-06" version="1">MQVPVVIVDDRERRSPVLSELARLGVRYSVARLEVGDYDVGGVYGVERKSSGDFVNSVIDGRLFEQAKYLRESYETAIIVVEGDLSEEVSRRQVSLNPLFGALAALAENGVSVLQVRSYAETALLIYVLWKRLQKHGSSFLVRSKKKVFKESTSIPVVQLNLIASLPGISREMADRILREFHTPRRFFTATPAELRRIHGLGPKRIQKILQVLDTSYVSAKMLSDSRKAEANSNEEELDQARGEGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM0</accession>
    <name>RNH2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
            <shortName evidence="1">RNase HII</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhB</name>
        <name type="ordered locus">Tpen_0899</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYM0"/>
    <dbReference type="SMR" id="A1RYM0"/>
    <dbReference type="STRING" id="368408.Tpen_0899"/>
    <dbReference type="EnsemblBacteria" id="ABL78300">
        <property type="protein sequence ID" value="ABL78300"/>
        <property type="gene ID" value="Tpen_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0899"/>
    <dbReference type="eggNOG" id="arCOG04121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_2"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000334987" description="Ribonuclease HII">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <sequence length="213" mass="23690" checksum="D9F23D0962099ADE" modified="2007-02-06" version="1">MGRVAGIDEAGRGPMLGPMVVAIVVCPEEKVPLLRNMGVRDSKALSPRRRLLLSRAIPSVGCSVKVRVVEPQEIDCAVRGECYENLNHLEAAVFAQLINEVLSEGELEVVYMDSPDPVPSRFEERVRALLKGQVRIVAENGADEKYTIVGAASIVAKETRDEIINALKKTYGDFGSGYPSDPRTLRFAEEWVRKHGEPPPIARKEWATWKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP3</accession>
    <name>A1RYP3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752588.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0922"/>
    <dbReference type="EnsemblBacteria" id="ABL78323">
        <property type="protein sequence ID" value="ABL78323"/>
        <property type="gene ID" value="Tpen_0922"/>
    </dbReference>
    <dbReference type="GeneID" id="4600818"/>
    <dbReference type="KEGG" id="tpe:Tpen_0922"/>
    <dbReference type="eggNOG" id="arCOG14689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531720_0_0_2"/>
    <dbReference type="OrthoDB" id="132698at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="512" mass="55765" checksum="05C508E5B4F3F614" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ0</accession>
    <name>A1RYQ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0929"/>
    <dbReference type="EnsemblBacteria" id="ABL78330">
        <property type="protein sequence ID" value="ABL78330"/>
        <property type="gene ID" value="Tpen_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0929"/>
    <dbReference type="eggNOG" id="arCOG03794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521947_0_0_2"/>
    <dbReference type="OMA" id="LASYAYF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="177" mass="18987" checksum="27F638FB9646EA83" modified="2007-02-06" version="1">MPSPVNRTAKLSLTALTAALALAFSVLKLEAPFPVLPYLKFDLAEVPVTLGFLLCGLPYGVAAETVHFLGLVARGADPLGAFMKFLAVVSMFLGAYRFSSAVTRLALGVAARVAAMTLASYAYFYLLFPGFLGYALKYTGSVYALFAYTALFNVIHGAATMALSMLVVREVKKRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR7</accession>
    <name>A1RYR7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2341 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752612.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0947"/>
    <dbReference type="EnsemblBacteria" id="ABL78347">
        <property type="protein sequence ID" value="ABL78347"/>
        <property type="gene ID" value="Tpen_0947"/>
    </dbReference>
    <dbReference type="GeneID" id="4601287"/>
    <dbReference type="KEGG" id="tpe:Tpen_0947"/>
    <dbReference type="eggNOG" id="arCOG03509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379313_0_0_2"/>
    <dbReference type="OrthoDB" id="43937at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018765">
        <property type="entry name" value="DUF2341"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10102">
        <property type="entry name" value="DUF2341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2341" evidence="1">
        <location>
            <begin position="439"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="730" mass="78535" checksum="33E926DE4F0237F8" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW4</accession>
    <name>A1RYW4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0994"/>
    <dbReference type="EnsemblBacteria" id="ABL78394">
        <property type="protein sequence ID" value="ABL78394"/>
        <property type="gene ID" value="Tpen_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0994"/>
    <dbReference type="HOGENOM" id="CLU_2730610_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="71" mass="8844" checksum="11BB1D67D2B30AC7" modified="2007-02-06" version="1">MYWYYYFPGGWYPPYWYPVPYPDPVSLMYAWSYMWSYWLSTIYYIEMYKAMLEAWRKMVEATFKAPVVPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX8</accession>
    <name>A1RYX8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1008"/>
    <dbReference type="EnsemblBacteria" id="ABL78408">
        <property type="protein sequence ID" value="ABL78408"/>
        <property type="gene ID" value="Tpen_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1008"/>
    <dbReference type="eggNOG" id="arCOG01211">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989091_0_0_2"/>
    <dbReference type="OrthoDB" id="106899at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="281" mass="30726" checksum="259F89136D98609A" modified="2007-02-06" version="1">MVIGIVESIQSALLSMLGDRLAGVVLFGSAARREDFTPLSDINVAVITNGKVPPEERVAIAEALGTDFSVVVLSVEELKQLASNGEFLAHEILRGGKILYADTSLYEALNFSPPVTSRTREFLERHALACVGLSLENYFAGRFHYALNYAYRGLRSAARCVSARDGELCFSDSEVAEALRRRGFEEAAEVYGRLRRGRFLGVGKGDLYQLLLSAYKQVFRVLGLGEPDFEGLVSRVEKTFVYVSEVKLTAERGRVKAEVAGVGAGGREERLEEPLVLAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY1</accession>
    <name>A1RYY1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752676.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1011"/>
    <dbReference type="EnsemblBacteria" id="ABL78411">
        <property type="protein sequence ID" value="ABL78411"/>
        <property type="gene ID" value="Tpen_1011"/>
    </dbReference>
    <dbReference type="GeneID" id="4600684"/>
    <dbReference type="KEGG" id="tpe:Tpen_1011"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_1_2"/>
    <dbReference type="OMA" id="PFDPWKS"/>
    <dbReference type="OrthoDB" id="37613at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="6">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="301" mass="33461" checksum="15A8035116185A3D" modified="2007-02-06" version="1">MAYVRPFDPWRSTSLCTCPFKYTVNPYTGCSHGCLYCYASSYIRDFFNPRPKKDFLKVVYGDLRRIPEGSIVNISSSSDPYQPLESKYGYTRRFLELAVGRYVVEVVTKSDLVARDADLLARGQSVVSVTITTMDNEVAKRLEPGAPPPSRRVKAVERLSEAGVPVVLRLDPLIPGLNDSEDSVREVVEAAVGAGARHVVSSTYKVKPDNLARLLKAFPELEPRLRKLYFEGGDRLHGYVYAEKSYRYRVLSTVREIAHGLGATFAVCREGFYDLIDRGVSCDGTHLARGRGAHAGEARPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY7</accession>
    <name>A1RYY7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">radA</name>
        <name evidence="10" type="ordered locus">Tpen_1017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1017"/>
    <dbReference type="EnsemblBacteria" id="ABL78417">
        <property type="protein sequence ID" value="ABL78417"/>
        <property type="gene ID" value="Tpen_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1017"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OMA" id="TFRIYLR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="122"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="9">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="40107" checksum="26505EC495DE759E" modified="2007-02-06" version="1">MPKRAKTEEVEEKEEKVEEEVNVDELVEDILGEAAAEAPPEEVPEGEIRLEDLEGVGRITAQKLRAAGFYTVRDLAFASAHELALVLGSEERAMAIIRSAQRLVNRGEEFITAKTLFEKRKNIEYISTGVRSLDDLLEGGIEVGSITEFIGEFGAGKTQICHQLSVMVQLPKDKGGLNARALYVDTEGTFRPERIVQIARARGLDPEKTLENIIYARAYNSDHQMLLIDEAKKYIEKYNIRLIIVDSLINHFRAEYPGRENLASRQQKLNKHISQLHRLASLYNLAVVVTNQVMASPDIFFGNPLKPAGGNIMAHGCTYRIWLRKAKEGKRIARIIDSPKHAEKEVAFAITEDGVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ19</accession>
    <name>A1RZ19_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752714.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1049"/>
    <dbReference type="EnsemblBacteria" id="ABL78449">
        <property type="protein sequence ID" value="ABL78449"/>
        <property type="gene ID" value="Tpen_1049"/>
    </dbReference>
    <dbReference type="GeneID" id="4600792"/>
    <dbReference type="KEGG" id="tpe:Tpen_1049"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100105_0_0_2"/>
    <dbReference type="OMA" id="IGIYHEG"/>
    <dbReference type="OrthoDB" id="83812at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="191" mass="20323" checksum="09C195021AEB77DF" modified="2007-02-06" version="1">MKNLVKTLLLAGPLAFAAFPVVVYFSASSNPWWSLYKHAFSDLGGPRAANPWIFNYGLMAMGLLVVVYSFGVLLASKTKYESFAAGLLFVAGVFLFLIGYYPSGTKPHTFVSLWFYLQSFIASTALGIALLLSGRKAVGTALLALGLVPVPLGTLIEATVGWPSVAILELAGALFIGASAIVATLHYIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ38</accession>
    <name>A1RZ38_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator, PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1069"/>
    <dbReference type="EnsemblBacteria" id="ABL78468">
        <property type="protein sequence ID" value="ABL78468"/>
        <property type="gene ID" value="Tpen_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1069"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="SMHRDAT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="340" mass="38179" checksum="93494A2E17C5833B" modified="2007-02-06" version="1">MREMTSNKVVRRVQLTGGSTFIVSIPKEWAEKLSIGKGSLLVLSLENDGSIRIVPSLKRPEALSSAEVSVREDTTRGAALREVMSKYLMGYKMIRVVFERDDPEFRHVLKDTIARKLIGVEILHEDSREVVLQVLVNVEDLPVSTIITKMRDAVTGMLEDVKAALGGGDVEKIASEIVSRDDIVDKLYLYGLRQLHAALRGYVGLEEIGLRKVEEVLPHGMVLKNIERIADHAASIAQALPHVREAEKIKNPISTLSDKVSEFFTASVHVFLDRDKTTANRLLDVDAEKLKALERKVFDELARRIPEEILAVRLMVGSYRRIFDYSTDILEATIDLHDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ45</accession>
    <name>A1RZ45_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
            <ecNumber evidence="8">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1076"/>
    <dbReference type="EnsemblBacteria" id="ABL78475">
        <property type="protein sequence ID" value="ABL78475"/>
        <property type="gene ID" value="Tpen_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1076"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_3_2"/>
    <dbReference type="OMA" id="SAQIRRW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="112"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="553" mass="58765" checksum="E7B0D683DFC72D8B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ49</accession>
    <name>A1RZ49_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Ubiquinone), 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752744.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1080"/>
    <dbReference type="EnsemblBacteria" id="ABL78479">
        <property type="protein sequence ID" value="ABL78479"/>
        <property type="gene ID" value="Tpen_1080"/>
    </dbReference>
    <dbReference type="GeneID" id="4601692"/>
    <dbReference type="KEGG" id="tpe:Tpen_1080"/>
    <dbReference type="eggNOG" id="arCOG01551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_1_2"/>
    <dbReference type="OMA" id="MEMPWIL"/>
    <dbReference type="OrthoDB" id="101801at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="161" mass="18360" checksum="C61DD04DD7324A92" modified="2007-02-06" version="1">MSGEKPSWLVALEGRLRELGAELEVQGSILRVRPAPGKVREVAAAAVEAGFDHLASVEGIDWPSKGVIEVVYHAESYEPEKRRFLFEVRVQLPREKPVTPSLFDVWPNALFMERETWEMLGVIFEGHPELRRLLLPPGWEGPPPLRKDFKVVEEGIYVEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ62</accession>
    <name>A1RZ62_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylglucosamine 6-phosphate deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752757.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1093"/>
    <dbReference type="EnsemblBacteria" id="ABL78492">
        <property type="protein sequence ID" value="ABL78492"/>
        <property type="gene ID" value="Tpen_1093"/>
    </dbReference>
    <dbReference type="GeneID" id="4600960"/>
    <dbReference type="KEGG" id="tpe:Tpen_1093"/>
    <dbReference type="eggNOG" id="arCOG00699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_2"/>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="OrthoDB" id="44408at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="48"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="385" mass="41379" checksum="6FA334C203D88EAA" modified="2007-02-06" version="1">MRVLVKNAHVLTPLGDLGVVNVMVKDGVVEGFDVEAVPDRVVDAERYYVAPGFIDTHIHGYGGVDVTEASAEEILEMSGGLAEHGVTGFLASTVAAPHERLLQACSNVAAASSRWSPSKGARILGVHLEGPYLNPKMKGAMNEQYFRKPSLRELDEYVSASRGLVRQVTVAPEVEGALEFIEEASRRGITVSVGHTDATYEQALRAVEAGARKANHIFNQMRGFHHREPGTAMALLLDTDVFVEMIVDFVHLHPATVRLVYRLAGPLRTVLITDAVRAAGLPDGEYTLGGLRIVVKEGVSRLADSGALAGSTLTMDRAVRNMTKVGANTLEALTMASYTPAKSVGALGRERVGLLRPGYAADMVVLDERLEVKKTIIAGEVVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ85</accession>
    <name>A1RZ85_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752780.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1117"/>
    <dbReference type="EnsemblBacteria" id="ABL78515">
        <property type="protein sequence ID" value="ABL78515"/>
        <property type="gene ID" value="Tpen_1117"/>
    </dbReference>
    <dbReference type="GeneID" id="4600859"/>
    <dbReference type="KEGG" id="tpe:Tpen_1117"/>
    <dbReference type="eggNOG" id="arCOG03042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406906_0_0_2"/>
    <dbReference type="OrthoDB" id="85654at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="675" mass="72525" checksum="563040F20E90FF17" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ98</accession>
    <name>A1RZ98_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752793.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1130"/>
    <dbReference type="EnsemblBacteria" id="ABL78528">
        <property type="protein sequence ID" value="ABL78528"/>
        <property type="gene ID" value="Tpen_1130"/>
    </dbReference>
    <dbReference type="GeneID" id="4602025"/>
    <dbReference type="KEGG" id="tpe:Tpen_1130"/>
    <dbReference type="eggNOG" id="arCOG03166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671970_0_0_2"/>
    <dbReference type="OMA" id="ITSTRHY"/>
    <dbReference type="OrthoDB" id="21930at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="421" mass="48744" checksum="E1DFEFDD0F674F71" modified="2007-02-06" version="1">MVSLTVVSIVRHSDLARWKSTGAWVLVYGRRKVGKSYFIRNFTKWDSYYFVGREGEIFVDSERISYEAFRRELAEKLKHNETVVVDEFQRLPSEFSDMLHSLGTRGRLVAVSSTLWLSREILSGRSPLLGMMTEFKMGLVDEADILVNLSSYVSDPKRLVEVSVLLREPWLTPVWERASNFERGVVQTLRYTVPALVGEVFREEERFLSRVYEGVLKAVASGKSVSSEIAAYLYSNRLMAAQDPSLVHPYLRVLERIGILEKVKFYGKNRYMYRHVSPVVDLFFYMDAKYGISERELEEEQALRVLREKMPLYVEQFVAYLLSKSMGLWAEKIVEPGHEVDVALVDFKSLKAAVEVKWRETLTSSDVEKIEERLSRYKCRKILVVPRGDVLPREPKGIEVFSAENLLELARTRVKKLQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD0</accession>
    <name>A1RZD0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1162"/>
    <dbReference type="EnsemblBacteria" id="ABL78560">
        <property type="protein sequence ID" value="ABL78560"/>
        <property type="gene ID" value="Tpen_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1162"/>
    <dbReference type="eggNOG" id="arCOG01860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_1_2"/>
    <dbReference type="OMA" id="IDDHDEW"/>
    <dbReference type="OrthoDB" id="62777at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="217" mass="24605" checksum="FDAC9D7053085F4C" modified="2007-02-06" version="1">MLLEVVEGEMLRRVAEEAVKFYRGSHHDLSHVERVYRLAMRIARELGAGVDLEVLGAAAILHDVARSMEDEGLVEDHAREGARIAREILKRVGFPEDKIERVAYCIEAHRYRGGGRPSSIEAQILQDADRLDALGAIGVARAFARGGARGTPFYDPSKPPKERYDGHSETVVNHFYEKLLKVKDTLNTEPARRIAEGRHRFMEEFLERFLKEWVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF2</accession>
    <name>A1RZF2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752847.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1184"/>
    <dbReference type="EnsemblBacteria" id="ABL78582">
        <property type="protein sequence ID" value="ABL78582"/>
        <property type="gene ID" value="Tpen_1184"/>
    </dbReference>
    <dbReference type="GeneID" id="4600429"/>
    <dbReference type="KEGG" id="tpe:Tpen_1184"/>
    <dbReference type="HOGENOM" id="CLU_856911_0_0_2"/>
    <dbReference type="OrthoDB" id="122906at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="324" mass="36613" checksum="B107B2141871AF10" modified="2007-02-06" version="1">MPQGSDASLFSALRFARSLSGLARATGLPIRALRKTLLGPGTPWRLRWRFDFRALGLRFVGVLSERSPEAYPFVLKVYPLEGLEKLFLVVALVDEQRVDALLDRLKPVTVVEALEYSFWTPDELLEKAGYGFSPLSYPGVMDLMDLPEEGGARVRPDKVDLAVISGKLTSPLATFRKAYESSRSLDPDLPRLTAQTLNRHVKKHVLPHWNGNYAYRYSDTEPVGVYLLEGWRSAPAARILVRLPGAHFALVDKNRAILVGQFSHEKRAALLSTLRELKVDMPPGELLCPPGSAKSYRWRFWRFIERRRWVDAGDAPLSAEDWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF9</accession>
    <name>A1RZF9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752854.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1191"/>
    <dbReference type="EnsemblBacteria" id="ABL78589">
        <property type="protein sequence ID" value="ABL78589"/>
        <property type="gene ID" value="Tpen_1191"/>
    </dbReference>
    <dbReference type="GeneID" id="4600436"/>
    <dbReference type="KEGG" id="tpe:Tpen_1191"/>
    <dbReference type="eggNOG" id="arCOG04253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_2"/>
    <dbReference type="OMA" id="VIQQGMN"/>
    <dbReference type="OrthoDB" id="61040at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="385" mass="42721" checksum="82CC468511484B5F" modified="2007-02-06" version="1">MKTGVAELPLHDGSVPRWLIARMERLAGILVEMIVEEYGTRGLLERLADPVYFQAINNIIGMDWDSSGSTTVTTAVLKKVLEERELGVKACGGKGSSSRKAPEEIRLHAEKYGLDPSGLVSTSYLVAKVDSAALQAGYQLYHHAFFFDEEGRWAVVQQGMKPSTRTARRYHWFSERVGDVTVEPHSGIHGFREPFALNTVAAEAGEFRRLVVDLVGEGASRLERLVSEALRVLEGYSPLVSYAPYSAEKARSLRERMRRLGKPSLSREALASLAGRGVESFRDILAAKAVGPSAIRALALVAELVYETPPSWRDPVTHQVDPFKFAYAVGGKDGVPFPVDRKTYDELISILEELKQRFRGEPGVFRRLAELTKNWTPPPEEKVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH6</accession>
    <name>A1RZH6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar binding protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1208"/>
    <dbReference type="EnsemblBacteria" id="ABL78606">
        <property type="protein sequence ID" value="ABL78606"/>
        <property type="gene ID" value="Tpen_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1208"/>
    <dbReference type="eggNOG" id="arCOG07728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_5_2"/>
    <dbReference type="OMA" id="DNIELRY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="35"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="34806" checksum="9434AEEE818F61D6" modified="2007-02-06" version="1">MVPYSKYAELEKKLEQLQAGAAAPEYTFYYVSHGGPADPWWAPVIKGSQDAARLLNVKVVYSGPEKFSIQALVDLLNSAIAAKPQGIILTITDYKALDEPARRAIAQGIPIIAVNVPDPRPPNERIPYLSYVGQNEYDAGYYLAKYLVDKGYKPKRVVIGIHEVGHIGLETRAKGITDAITQAYPGTPVEKLDITTDPTKAAEVFKSYLTAHPDTDVIFTLGPLGAHPALQVLREMKLTGKVHLLTVDIDNVILKAIEAGELDAAVSQQPYAQGFLPVVFMYLYVKYGIIPPPQVPTGPTVIDKAKLETVKKQIATTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL8</accession>
    <name>A1RZL8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752913.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1250"/>
    <dbReference type="EnsemblBacteria" id="ABL78648">
        <property type="protein sequence ID" value="ABL78648"/>
        <property type="gene ID" value="Tpen_1250"/>
    </dbReference>
    <dbReference type="GeneID" id="4600545"/>
    <dbReference type="KEGG" id="tpe:Tpen_1250"/>
    <dbReference type="eggNOG" id="arCOG00673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439175_0_0_2"/>
    <dbReference type="OrthoDB" id="93075at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="608" mass="66499" checksum="85803E4CFC89F62B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP1</accession>
    <name>A1RZP1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1273"/>
    <dbReference type="EnsemblBacteria" id="ABL78671">
        <property type="protein sequence ID" value="ABL78671"/>
        <property type="gene ID" value="Tpen_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1273"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="RWFGNVV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="318" mass="34753" checksum="E83A10B0FBBC432A" modified="2007-02-06" version="1">MLRKFLYRACVQAGGMIEVRGVYKSFGKARVLEDVSFSVRNGEVVGFVGLNGAGKTTTIRITVGVLPPDAGDVFIDGYSVSEDKVEASARVGWVPELPIFESEYRALDYFAYLAGYYGYSEGEARRLGRELFERVGIGEAANKRLEEFSQGMKKRFALAVSLINDPPNFLFDEVLNGLDPQGIAFFRGLVQEFRKAGKAVLFSSHILSEVEGLADRVVFIHRGRIVGTYTMDEIRRRASGELLVSVSPLDDGAASIAAKYGEPEKRGNALAVKGFSGDPSSLVAELVAAGYRVAEVKRSEKSLEEFFFELVGLRGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ1</accession>
    <name>A1RZQ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1283"/>
    <dbReference type="EnsemblBacteria" id="ABL78681">
        <property type="protein sequence ID" value="ABL78681"/>
        <property type="gene ID" value="Tpen_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1283"/>
    <dbReference type="HOGENOM" id="CLU_2103638_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="115" mass="12594" checksum="BAB85125F3E85038" modified="2007-02-06" version="1">MRSVVLAYAELLACAVDLDPAGAAMGVVCSRVFFDCFRLEKVSVVDGVSDEWLVVEAKLELCIDEYVLVVQEDRVSVYLGRELVASTPLRRGGSFLSALLDLFKGEDVVVGDFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR5</accession>
    <name>A1RZR5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752960.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="CAZy" id="GH20">
        <property type="family name" value="Glycoside Hydrolase Family 20"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78695">
        <property type="protein sequence ID" value="ABL78695"/>
        <property type="gene ID" value="Tpen_1297"/>
    </dbReference>
    <dbReference type="GeneID" id="4600651"/>
    <dbReference type="KEGG" id="tpe:Tpen_1297"/>
    <dbReference type="eggNOG" id="arCOG07452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495781_0_0_2"/>
    <dbReference type="OMA" id="DETWALG"/>
    <dbReference type="OrthoDB" id="49947at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="99"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="557" mass="64553" checksum="76B6563156EDBEA4" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT5</accession>
    <name>A1RZT5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1318"/>
    <dbReference type="EnsemblBacteria" id="ABL78715">
        <property type="protein sequence ID" value="ABL78715"/>
        <property type="gene ID" value="Tpen_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1318"/>
    <dbReference type="eggNOG" id="arCOG03891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464346_0_0_2"/>
    <dbReference type="OMA" id="PFERRIW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="587" mass="63773" checksum="C8F7B437D0364873" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-05-16" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT8</accession>
    <name>CAS1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas1</name>
        <name type="ordered locus">Tpen_1321</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752983.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZT8"/>
    <dbReference type="SMR" id="A1RZT8"/>
    <dbReference type="STRING" id="368408.Tpen_1321"/>
    <dbReference type="EnsemblBacteria" id="ABL78718">
        <property type="protein sequence ID" value="ABL78718"/>
        <property type="gene ID" value="Tpen_1321"/>
    </dbReference>
    <dbReference type="GeneID" id="4602001"/>
    <dbReference type="KEGG" id="tpe:Tpen_1321"/>
    <dbReference type="eggNOG" id="arCOG01452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_0_0_2"/>
    <dbReference type="OMA" id="TYDFSEM"/>
    <dbReference type="OrthoDB" id="70037at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000417113" description="CRISPR-associated endonuclease Cas1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <sequence length="327" mass="36349" checksum="4F3F7F54F61F3D67" modified="2007-02-06" version="1">MRLLVLRGVDEVTVSSRSTVVIKSGNRVFERALRDVDAVLVVGSGIKISSSLPPVLALHGIPLSILAKGHVAVLLNPVGTKYNNYRALQYTLPKNKALAIALEYLKSRVRGMASIIRNRGGRLPALPEPPDPALYEDPARLESDIRSWEAAASNTLWDEVFKLLDPSAARELRERYGFAGRKPGHPDPLNKAISAMYAVLYTLSTKALVAAGLDPTYGFLHRTQYSVPLAFDYAEAFKPLAVEAALDLVNEEGLPTLSEDGDLDKDSLNKAMKRLYRYLSAKHRETGKTPYQQIHLKAFCLAKHLEGKCSREKLAFTWDKKRYIIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU6</accession>
    <name>A1RZU6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1329"/>
    <dbReference type="EnsemblBacteria" id="ABL78726">
        <property type="protein sequence ID" value="ABL78726"/>
        <property type="gene ID" value="Tpen_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1329"/>
    <dbReference type="eggNOG" id="arCOG12288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151094_0_0_2"/>
    <dbReference type="OMA" id="CYSCIAN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="142" mass="15123" checksum="70ECBB694EA3AAA1" modified="2007-02-06" version="1">MVARRDVPGFLKALTAKLLGTWLSRLLVLLLLAASLVGVLTGCYSCIANVAEIVLAFFAYAYVHEVAQFLFIDSDVEVAYEDGALTLRAVGEPRWPRLAVACGIVAPGVLGAAALGSFPAFGLVVLLLTLITLLRYLADEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW3</accession>
    <name>A1RZW3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753008.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1346"/>
    <dbReference type="EnsemblBacteria" id="ABL78743">
        <property type="protein sequence ID" value="ABL78743"/>
        <property type="gene ID" value="Tpen_1346"/>
    </dbReference>
    <dbReference type="GeneID" id="4600870"/>
    <dbReference type="KEGG" id="tpe:Tpen_1346"/>
    <dbReference type="eggNOG" id="arCOG03886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175992_0_0_2"/>
    <dbReference type="OMA" id="PVARMGW"/>
    <dbReference type="OrthoDB" id="129929at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="108" mass="11870" checksum="478D3293F4958254" modified="2007-02-06" version="1">MARLTVSIDDDLAERLRRAAEALYGSRRRVSRVVEDALRSYLASLEIEENVRYLAVKGGETLAEAKTLSELAAKLRELGVDTRGVRIVRSGSPKSPARGGYRLKPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX1</accession>
    <name>A1RZX1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753016.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1354"/>
    <dbReference type="EnsemblBacteria" id="ABL78751">
        <property type="protein sequence ID" value="ABL78751"/>
        <property type="gene ID" value="Tpen_1354"/>
    </dbReference>
    <dbReference type="GeneID" id="4602191"/>
    <dbReference type="KEGG" id="tpe:Tpen_1354"/>
    <dbReference type="eggNOG" id="arCOG01444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031100_1_0_2"/>
    <dbReference type="OMA" id="MLIHGRM"/>
    <dbReference type="OrthoDB" id="18962at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="566" mass="61701" checksum="C2DA978DF32360D6" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY5</accession>
    <name>A1RZY5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1368"/>
    <dbReference type="EnsemblBacteria" id="ABL78765">
        <property type="protein sequence ID" value="ABL78765"/>
        <property type="gene ID" value="Tpen_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1368"/>
    <dbReference type="HOGENOM" id="CLU_2243993_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="104" mass="11329" checksum="C18CF2C861C124EA" modified="2007-02-06" version="1">MLRLHDAGYSVLRVGLLDGSLLPPTAVLDEPRLAEADPAVGGRLLVECSAAQCWELALALAARCRRVAWSARRPDTLAVVAENLRVSELFERGARLLKPFRSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ5</accession>
    <name>A1RZZ5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753040.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1378"/>
    <dbReference type="EnsemblBacteria" id="ABL78775">
        <property type="protein sequence ID" value="ABL78775"/>
        <property type="gene ID" value="Tpen_1378"/>
    </dbReference>
    <dbReference type="GeneID" id="4600366"/>
    <dbReference type="KEGG" id="tpe:Tpen_1378"/>
    <dbReference type="eggNOG" id="arCOG00729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_5_1_2"/>
    <dbReference type="OMA" id="ELGNIVW"/>
    <dbReference type="OrthoDB" id="116013at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="136" mass="15373" checksum="D5171CDB089BE809" modified="2007-02-06" version="1">MYVFDASSIVNLVKKGSAKVFELGVTLDLALYESLNSVWKEYKLLGRIDRETAANYADVLAKVFEGIKSLSIKGSERDVLEIALKENLTVYDASYLYLAMRDGRTLVTDDRKLRDKASRYVRVLSSDEIASRHLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ6</accession>
    <name>A1RZZ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753041.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1379"/>
    <dbReference type="EnsemblBacteria" id="ABL78776">
        <property type="protein sequence ID" value="ABL78776"/>
        <property type="gene ID" value="Tpen_1379"/>
    </dbReference>
    <dbReference type="GeneID" id="4600367"/>
    <dbReference type="KEGG" id="tpe:Tpen_1379"/>
    <dbReference type="eggNOG" id="arCOG02218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_1_1_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8882" checksum="30FE7DE6291C71F5" modified="2007-02-06" version="1">MKYVTVSAKIPRELKELMDKYGVKPGPVIREALEREIRRRILEEAEKLARELSKKVSHIPDEEIARIIREDREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S017</accession>
    <name>A1S017_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753062.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1400"/>
    <dbReference type="EnsemblBacteria" id="ABL78797">
        <property type="protein sequence ID" value="ABL78797"/>
        <property type="gene ID" value="Tpen_1400"/>
    </dbReference>
    <dbReference type="GeneID" id="4600464"/>
    <dbReference type="KEGG" id="tpe:Tpen_1400"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="RTRGQMW"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="334" mass="36742" checksum="A7067732EFB78266" modified="2007-02-06" version="1">MSGGAVVAKNLVKVFRTREGGALFRGKRREVVALQGVSFEIRPGEIFGLLGPNGAGKTTTIKILSTLLLPDSGEAWVNGYSVLEEPRKVRESIGVSLYSDRGFYWKLTGRENLEYFARLYHLERGYARRRIEELLKLLDLEKDADRLVEEYSTGMKSKLNIARALLHDPPVLFLDEPTIGLDPNSARKVREVVLELKKSGKTILLTTHNMFEADMLADRVAIINKGRIIAVGSPRELKSRISGKQVVEVEVAGRPEEVREKVKSVQGVLATSLSAGSGNPYAGTLRVVYEGDGVLREVLSAVLDSGAKLLSVRTVEPTLEDVFAFYTGGGLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S034</accession>
    <name>A1S034_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1417"/>
    <dbReference type="EnsemblBacteria" id="ABL78814">
        <property type="protein sequence ID" value="ABL78814"/>
        <property type="gene ID" value="Tpen_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1417"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="IHMEVGQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="406" mass="44171" checksum="7A6B1B183E8BA066" modified="2007-02-06" version="1">MRATRLAVSPLRLPRRRRGADFLEMDPSFEFLEKAGKGAVSFGIGQPDFSPPGEVLEALRTVGAEALKYTPPLGLPELREALAGYLSEKYGVDVKPSEVAVTPGATAAVFASLVLLVRGRARVVVQDPGFPMYDDVARFAGGRVVYAYSGIEESFEWSAESIAGRLGEGGVAVLNFPNNPTGSLAPRGLLEELGGLAARKGFYVVSDEVYEDFVYEGSHESVLQVPELRERSVYVGSFSKTWGLAGLRLGYVVAPRRLVERLEAVAVNVYGSPPSPAQLAALRALDHGLGWFSGVLSEYRRRRDALLEELSKVEGVELYRPRGAFYVYPRVRGLLKRLGVGSSRELAESLLQAGVVVLPGDAYSGRAGREHVRLSYALPVESIREGVRRIRAFVEEAACARRKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S099</accession>
    <name>A1S099_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753144.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1482"/>
    <dbReference type="EnsemblBacteria" id="ABL78879">
        <property type="protein sequence ID" value="ABL78879"/>
        <property type="gene ID" value="Tpen_1482"/>
    </dbReference>
    <dbReference type="GeneID" id="4601277"/>
    <dbReference type="KEGG" id="tpe:Tpen_1482"/>
    <dbReference type="eggNOG" id="arCOG03639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086262_0_0_2"/>
    <dbReference type="OrthoDB" id="97733at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="268" mass="28949" checksum="ECAAF57BE26F9446" modified="2007-02-06" version="1">MCRQLIAVGNLSELPPAVLEAFAKASACDPLMPSVAGTGKCGRHGDGWGFAAVTLEEYQRVEHYRSTIPVYEDAWGFEKLRRALRGEGVLVVHARKASAGSVSARNTHPIHYGWRGYEMFLAHNGSMRAGDLAASLGVPVLPDVTDTFYLGEYVYRRLDLPGAGNLAEAFGEAARYTETAMNVAAMLWGSSLLGVAVSYLSPGLLGSEVHERYYRLLLLRGDGWVAVFSSTLAEYLGGEGFEELPFQSGLALSVERGGGVRVRAFRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B1</accession>
    <name>A1S0B1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753156.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="SMR" id="A1S0B1"/>
    <dbReference type="STRING" id="368408.Tpen_1494"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78891">
        <property type="protein sequence ID" value="ABL78891"/>
        <property type="gene ID" value="Tpen_1494"/>
    </dbReference>
    <dbReference type="GeneID" id="4601403"/>
    <dbReference type="KEGG" id="tpe:Tpen_1494"/>
    <dbReference type="eggNOG" id="arCOG04634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_2"/>
    <dbReference type="OMA" id="VEPAYEF"/>
    <dbReference type="OrthoDB" id="7579at2157"/>
    <dbReference type="BRENDA" id="3.2.1.21">
        <property type="organism ID" value="11662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="611"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="701" mass="77783" checksum="CF679BD2CBB62069" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D0</accession>
    <name>A1S0D0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753175.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1513"/>
    <dbReference type="EnsemblBacteria" id="ABL78910">
        <property type="protein sequence ID" value="ABL78910"/>
        <property type="gene ID" value="Tpen_1513"/>
    </dbReference>
    <dbReference type="GeneID" id="4601109"/>
    <dbReference type="KEGG" id="tpe:Tpen_1513"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OMA" id="HKAFGIH"/>
    <dbReference type="OrthoDB" id="100605at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="423" mass="43767" checksum="2C7948BF55D76FC8" modified="2007-02-06" version="1">MAGEKGFRRSLTLLDAVSVGLGAIIGAGIFVLIGIAAGLAGPAVVLAVLVSGLSASLTALSFAELGSALPRAGGVYEYGHTLLHPAVGFLMGWMWVAGNIVLGATASQGFGYYLSALVPSVNPRVAALALVVLVTLLNALGAKLSAVVNDVFVAVKVSVLLLLVAAGAALVKPENFQPFAPKGLLPVMEASALFYFAYIGFPRISTLAEEVKDPEKNIPRAILLALAVSAALYALVAVVAVGVAGYEALASSNAPLEEVARRVGVGWVVGVGGLVATFSVVLTSVMGQSRVFYAMARNREIPDKIAEINEKLGTPVYSVLLSGTVMLVLVALFDISRLAMVTSFLVLVSHVLTNVADVKLYLDGVDPPFRSPLRPWHAVAGAFTSLLLSLSVEKTALAMGLAVIAAGALWFFAYTRAQHGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D4</accession>
    <name>A1S0D4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1517"/>
    <dbReference type="EnsemblBacteria" id="ABL78914">
        <property type="protein sequence ID" value="ABL78914"/>
        <property type="gene ID" value="Tpen_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1517"/>
    <dbReference type="eggNOG" id="arCOG03724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754806_0_0_2"/>
    <dbReference type="OMA" id="SIFKWMI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="148" mass="16930" checksum="DFEFB86ED850508C" modified="2007-02-06" version="1">MSLSIAEKLLEELRQREDLRRGLAEELVSEIFGDRRLRIAVLTALYRDVATKQDLKELREGIRGDIVSRADTVEQKIGALEQRFNSLEQRINLLEQKIDLVERRVGSLEQRIARLEGMMGLFVKLFIAFNVPILVGVVGILLKMALFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I9</accession>
    <name>A1S0I9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1574"/>
    <dbReference type="EnsemblBacteria" id="ABL78969">
        <property type="protein sequence ID" value="ABL78969"/>
        <property type="gene ID" value="Tpen_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1574"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338230_0_0_2"/>
    <dbReference type="OMA" id="FELPYSH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_27" evidence="2">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="443"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="840" mass="97231" checksum="0EDCA4E4C9A2933B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K9</accession>
    <name>A1S0K9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1594"/>
    <dbReference type="EnsemblBacteria" id="ABL78989">
        <property type="protein sequence ID" value="ABL78989"/>
        <property type="gene ID" value="Tpen_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1594"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="323" mass="36384" checksum="FADDFAA96F8AA811" modified="2007-02-06" version="1">MVSEAIRVENLVKRFKDVTAVDGVSFTVREGEIYGLLGPNGAGKTTTIHILTTLLRPTSGRALVAGYDVVKQPSEVRKRIGIVFQDPSLDNQLTAWDNMYIHGMLYGLGGQELKRKINELLDFVELKNFANKQVKYFSGGMRRRLEIARALLHEPEILFLDEPTIGLDPQTRVKIWDYIMAIKKEKGMTIVLTTHYMDEAEQLCDRIAIMDRGKIIAEGTSDELKALVGNEVIYLKLDGSAPACLEADFISSCRIVSGGLVELSVKNASQAMPRVFELAEEKGLKIVEVTYRRPTLNEVFIHLTGRELRDSLEESPRPPHRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M1</accession>
    <name>A1S0M1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753266.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1606"/>
    <dbReference type="EnsemblBacteria" id="ABL79001">
        <property type="protein sequence ID" value="ABL79001"/>
        <property type="gene ID" value="Tpen_1606"/>
    </dbReference>
    <dbReference type="GeneID" id="4601537"/>
    <dbReference type="KEGG" id="tpe:Tpen_1606"/>
    <dbReference type="eggNOG" id="arCOG01097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_2"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="OrthoDB" id="82596at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="185" mass="20796" checksum="E3574C1D4EF470FA" modified="2007-02-06" version="1">MKLHEITRDLLLSAFGGESMAHMRYLVFAEIADREGFPNVARLFRAIAYAEFVHAKNHYGNLGDYKEAFPVYAGTPAGPGTTSKNLELAIMGEEYEVNEMYPAYIEVARFQGEKGAERSFRWALEAEKIHAKLYREAKASVDQGKDWPIDGKVWVCPVCGHTYVGPEPPEKCPICGAPREKYQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M3</accession>
    <name>A1S0M3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753268.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1608"/>
    <dbReference type="EnsemblBacteria" id="ABL79003">
        <property type="protein sequence ID" value="ABL79003"/>
        <property type="gene ID" value="Tpen_1608"/>
    </dbReference>
    <dbReference type="GeneID" id="4601539"/>
    <dbReference type="KEGG" id="tpe:Tpen_1608"/>
    <dbReference type="eggNOG" id="arCOG00761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730611_0_0_2"/>
    <dbReference type="OrthoDB" id="117039at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="71" mass="8051" checksum="19D950BAA141B5D9" modified="2007-02-06" version="1">MQAKGFEERVLACRYSCFRSPVALSVVRLVKREGRLLCVEGLDLFDGTPVLDIKPCQSTRMHAHRSGFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N5</accession>
    <name>A1S0N5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
            <ecNumber evidence="1">4.3.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.3.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753280.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1620"/>
    <dbReference type="EnsemblBacteria" id="ABL79015">
        <property type="protein sequence ID" value="ABL79015"/>
        <property type="gene ID" value="Tpen_1620"/>
    </dbReference>
    <dbReference type="GeneID" id="4601912"/>
    <dbReference type="KEGG" id="tpe:Tpen_1620"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="LPPMRYK"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="33030" checksum="DA5BDEC52036BA7B" modified="2007-02-06" version="1">MPVTRLYGIIPPLITPFDTKGNLSVDRLSGIVEFTKPYVHGYYLCGTYGLGPLMRTDQRKKVAERVAELVGGEKLIVVHVGSADTETAVELAKHAQDIGAHAVASVPPFYYHHSETHILNFFRELVDSVSIPVYAYNNPPRVGYPITPELALKLKEVGVAGIKDSSFDVQAFIDYKVTLGEDFDVVVGTEALMLPTYVLGARAFIPGMSNYAPEIVFKLFKALENRDFENAAKIQYKINKVRRQVQRLGPTIPLVYLALKLRGVDAGFPRKPFLPAPHEVQEILKSYIEELLEGVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R8</accession>
    <name>A1S0R8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753313.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1653"/>
    <dbReference type="EnsemblBacteria" id="ABL79048">
        <property type="protein sequence ID" value="ABL79048"/>
        <property type="gene ID" value="Tpen_1653"/>
    </dbReference>
    <dbReference type="GeneID" id="4601730"/>
    <dbReference type="KEGG" id="tpe:Tpen_1653"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_2"/>
    <dbReference type="OMA" id="IKWANLV"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="388" mass="41666" checksum="2FA9925AC25FC1F6" modified="2007-02-06" version="1">MPEKDGKPGIRNVYALGFVSLFTDVSTEMINGYLPVFLVQELGATRALLGLIEGIGELANYFFRLVSGYISDRLGRRKALVFAGYSLSAVSKPLFAFAHSPWDALVVKALDRTGKGIRTSPRDALISQSIDEESSGKAFGLHRTIDQSGAMIGPLLATLLLPLIGPRNLFLVSFIPAVIALAILLAFVVDVKTESREARILKGARQVLGNKRLLLVLAAFAVMGLGYYDFSFLLVRSREVGVAADLVPLVYLAINLFHTAVGYPSGVLSDRVGKEKVLVGSLVFFALASIALARTENLAGFAVAVVLYGVFFGSYETVSRAILPRFAPPELRGTVYGVFYIATGLATLAGMTVVGYLWDTAGRAVAFTYSATLSLIAALLFAYSTRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S1</accession>
    <name>A1S0S1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753316.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1656"/>
    <dbReference type="EnsemblBacteria" id="ABL79051">
        <property type="protein sequence ID" value="ABL79051"/>
        <property type="gene ID" value="Tpen_1656"/>
    </dbReference>
    <dbReference type="GeneID" id="4601733"/>
    <dbReference type="KEGG" id="tpe:Tpen_1656"/>
    <dbReference type="eggNOG" id="arCOG01075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_2_2"/>
    <dbReference type="OMA" id="PHAALWR"/>
    <dbReference type="OrthoDB" id="116493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="152" mass="15974" checksum="BFE53FFF8B6AD688" modified="2007-02-06" version="1">MYPAHAVAAVSCVVKKGGKFLLVKRGKDPGRGLWAFPGGVIEAGEGVFDAAKRELYEETGLSANPLGVVGVTEVIHTDGGRVKHHYVILSVLFDEESLEGSPRAGGDVEEVAWMSLDEILGRGDVVASVKALSADLQGGPCTLGVYTLRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T8</accession>
    <name>A1S0T8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1673"/>
    <dbReference type="EnsemblBacteria" id="ABL79068">
        <property type="protein sequence ID" value="ABL79068"/>
        <property type="gene ID" value="Tpen_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1673"/>
    <dbReference type="eggNOG" id="arCOG02224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140145_0_0_2"/>
    <dbReference type="OMA" id="LMISVEM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="159" mass="18289" checksum="AE5D1F675A2BC1B6" modified="2007-02-06" version="1">MEYPLAPSTDILLDAPALALLHSIRYKNLIPLIVARYKVHVTVFSLVEFLTYLYYSRKTKDGLKVLTMLKNIYDVIEHLDDNVAQRTAMIMSDLLHHSLSAPFEDIVNVAYVLEKNFVLVSGDPSRYEALQKYGFLMISVEMLIQEIENYLKTSKENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W3</accession>
    <name>A1S0W3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753358.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1698"/>
    <dbReference type="EnsemblBacteria" id="ABL79093">
        <property type="protein sequence ID" value="ABL79093"/>
        <property type="gene ID" value="Tpen_1698"/>
    </dbReference>
    <dbReference type="GeneID" id="4601021"/>
    <dbReference type="KEGG" id="tpe:Tpen_1698"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_2_2"/>
    <dbReference type="OMA" id="FYTLARY"/>
    <dbReference type="OrthoDB" id="111480at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14782" checksum="AFE145CF7FE1BA83" modified="2007-02-06" version="1">MVREEAVDWLEEAVADLERAVRAEGVGDYSLACFMAQQAVEKAFKACYIGLLRRRPPRAHDLVMLYSELKGTLSLPGDVEEALPELSQYYVTARYPNAGLRRPSASFSRAQAVRAIEVARGVVERVREALATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y5</accession>
    <name>A1S0Y5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753380.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1720"/>
    <dbReference type="EnsemblBacteria" id="ABL79115">
        <property type="protein sequence ID" value="ABL79115"/>
        <property type="gene ID" value="Tpen_1720"/>
    </dbReference>
    <dbReference type="GeneID" id="4601745"/>
    <dbReference type="KEGG" id="tpe:Tpen_1720"/>
    <dbReference type="eggNOG" id="arCOG00665">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_2"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="OrthoDB" id="78828at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="296" mass="32715" checksum="3A7A666A5615153D" modified="2007-02-06" version="1">MLKKAVITAAGLGTRLLPITKELPKEMLPLFSVSDNAVGLKPIIHIVFESLLGVGVSEVCFIVGKSKRAIEDYFTPDADFIEVLRAKGVENRANELMKFYSAIRNAKIFFINQPEPRGFGDAVLRAEPFVGADPFIVHAGDDAVISEGHNHLRRLVKVFQEYDCDATLLAEDVEDPRAYGVLRGKVVNDYGSILRVLDIIEKPREPPTNIAAIAVYAFKPKIFSYLRNVKPDSGGEVQLTAAIKAMIDDGCDVCAVKLKPGERRLDVGTPQSYWKALYESYQLAVRRMLVSVMSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z9</accession>
    <name>A1S0Z9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753394.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1734"/>
    <dbReference type="EnsemblBacteria" id="ABL79129">
        <property type="protein sequence ID" value="ABL79129"/>
        <property type="gene ID" value="Tpen_1734"/>
    </dbReference>
    <dbReference type="GeneID" id="4601759"/>
    <dbReference type="KEGG" id="tpe:Tpen_1734"/>
    <dbReference type="eggNOG" id="arCOG02270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379580_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="94" mass="10795" checksum="496187C3AE983021" modified="2007-02-06" version="1">MEEAADVKVRVYYAPELDTLDLWLDEPGRESFSEPLNDNIVLKLDERREVIGLEIVSLGSLTREDVQVIPEGVRRVLLEALKRLYSRTLARLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S119</accession>
    <name>A1S119_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1754"/>
    <dbReference type="EnsemblBacteria" id="ABL79149">
        <property type="protein sequence ID" value="ABL79149"/>
        <property type="gene ID" value="Tpen_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1754"/>
    <dbReference type="eggNOG" id="arCOG02900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859455_0_0_2"/>
    <dbReference type="OMA" id="INVEISM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="101"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="327" mass="34634" checksum="52B1C640709CD565" modified="2007-02-06" version="1">MYFEKPELLLAGPLLAVLLYYLHVKGYRRFYAKKSSLKNPLAAYAGTGGAEPRRLGTLALKVLLAVLVGVALAGPYIVVEKRVERSGSAELNVSLNVARPAAVLVVDVSGSMEDSIPGGVKIEVARRAATLLVERMPGGVDVGLLAFSDRIVLSLPPTGDRRRVLDAIESLKPGGGTMYTYPLQAALSWLKPYKLFNASTLVVFVSDGLPADAATYRTLLSEFRSLGIPVYTVYIGPGGDEGERELKLIAGSTGGEEYTAGSAEELLKAFKTLAEKASSILVRASAVGVAGGVVEEKVGLSWAFAVSALIVTLILLYARSRESGVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S149</accession>
    <name>A1S149_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79179">
        <property type="protein sequence ID" value="ABL79179"/>
        <property type="gene ID" value="Tpen_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1784"/>
    <dbReference type="eggNOG" id="arCOG05500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840685_0_0_2"/>
    <dbReference type="OrthoDB" id="125541at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="140" mass="16321" checksum="03E4E65D1EB8A193" modified="2007-02-06" version="1">MGFSGYVQKSRETRVKQALREAREIIRRTLGGQPGGSLEEALRDLYERVPREEWLRRALARYLLGTVERQGSSTWVVRGVPELGDRKPLYIVTFTGDRYECSCYRGAYGWARRRSICTHIGAVMLERRRRRIDDYAYGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S179</accession>
    <name>A1S179_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753474.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1814"/>
    <dbReference type="EnsemblBacteria" id="ABL79209">
        <property type="protein sequence ID" value="ABL79209"/>
        <property type="gene ID" value="Tpen_1814"/>
    </dbReference>
    <dbReference type="GeneID" id="4602051"/>
    <dbReference type="KEGG" id="tpe:Tpen_1814"/>
    <dbReference type="eggNOG" id="arCOG00041">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_2"/>
    <dbReference type="OMA" id="ECPAYLI"/>
    <dbReference type="OrthoDB" id="115683at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="217" mass="22990" checksum="916F3D773FB29A9B" modified="2007-02-06" version="1">MVRVFRNREDAGKQLAEKLLAEGVGGPDVKVLGIPRGGVVVAKSVSEALGVQLDVVVSRKLRAPGNPELGIGAVAELDAVYINREIVDALGIGEDYIRSEVEYQRRVVASYVEKFRGTALDLRGFTAVVVDDGVATGATVIAASIAARKAGAEKVVVATPVIARDVLGVVSRYADKVVAVTVPLILYAVGEFYRDFSEVTDSDVLRALGRSPERRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A9</accession>
    <name>A1S1A9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751364.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1844"/>
    <dbReference type="EnsemblBacteria" id="ABL79239">
        <property type="protein sequence ID" value="ABL79239"/>
        <property type="gene ID" value="Tpen_1844"/>
    </dbReference>
    <dbReference type="GeneID" id="4600317"/>
    <dbReference type="KEGG" id="tpe:Tpen_1844"/>
    <dbReference type="HOGENOM" id="CLU_2713053_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="72" mass="8000" checksum="E4F8E3CA7AEF9823" modified="2007-02-06" version="1">MPRKKGIAKAVSRVLKSDAFAVAVFVLFMVGAIIVGWNPFGYTLGLPNLLLEGVFVLGMYFIYATKLRHRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B9</accession>
    <name>A1S1B9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751374.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1854"/>
    <dbReference type="EnsemblBacteria" id="ABL79249">
        <property type="protein sequence ID" value="ABL79249"/>
        <property type="gene ID" value="Tpen_1854"/>
    </dbReference>
    <dbReference type="GeneID" id="4600313"/>
    <dbReference type="KEGG" id="tpe:Tpen_1854"/>
    <dbReference type="HOGENOM" id="CLU_1912446_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="15155" checksum="BDC4E4C60B83FEB8" modified="2007-02-06" version="1">MPRDKNYLFKVKVKRYKRGGHVVEIVARGQGLKSAYYLIDKLLNNELIHYQPTSVVRRLKKRQRLEGGGKRFVIESKPVKPREKKPPENEKPQNFEANPPPSPPAPAEDSEEELPSFVKGNPWVGILSQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D0</accession>
    <name>A1S1D0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1865"/>
    <dbReference type="EnsemblBacteria" id="ABL79260">
        <property type="protein sequence ID" value="ABL79260"/>
        <property type="gene ID" value="Tpen_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1865"/>
    <dbReference type="HOGENOM" id="CLU_1507462_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="178" mass="19781" checksum="23173015AFD1F6AC" modified="2007-02-06" version="1">MRIDRRLGFRLSRALRPSVVRLHGEAGGQAQPFIPLRIRRLRLLPPLLPSPAPSGARGGEGVVQREVKLCLALAGLSRVADMATTLPILQKYGLQGELNPVARAFFGMGVTGIAFALVAGTVLSVFLAWVNWRRGGKKYLYLFTAFLWIPFFNNIVAYFNARNYTLVDFLFLALRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E0</accession>
    <name>A1S1E0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="7">pTPEN01</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751395.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1875"/>
    <dbReference type="EnsemblBacteria" id="ABL79270">
        <property type="protein sequence ID" value="ABL79270"/>
        <property type="gene ID" value="Tpen_1875"/>
    </dbReference>
    <dbReference type="GeneID" id="4600333"/>
    <dbReference type="KEGG" id="tpe:Tpen_1875"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431912_0_0_2"/>
    <dbReference type="OrthoDB" id="14047at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="265"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="497"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="633" mass="71623" checksum="F6802DFE46938341" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW38</accession>
    <name>A1RW38_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0008"/>
    <dbReference type="EnsemblBacteria" id="ABL77418">
        <property type="protein sequence ID" value="ABL77418"/>
        <property type="gene ID" value="Tpen_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0008"/>
    <dbReference type="eggNOG" id="arCOG07678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1458261_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="185" mass="19725" checksum="0346E42FB7986088" modified="2007-02-06" version="1">MALVALSAAVYGGLLAATAPITIVPGFTWLRPGNALAPLFGMFFGIPGCLGAAIGNLLADILSGYFGVGSFGGFIGNFLIAYIPFKFVRDHSFGSASSIGEFYIWGVIVQAFVSAIYICWWLDVMQSVVGLPVFVIWAVIATSILINNITVNAVLSPILGVILFPLVKSRGLYWKDRVMPQKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW39</accession>
    <name>A1RW39_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751684.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0009"/>
    <dbReference type="EnsemblBacteria" id="ABL77419">
        <property type="protein sequence ID" value="ABL77419"/>
        <property type="gene ID" value="Tpen_0009"/>
    </dbReference>
    <dbReference type="GeneID" id="4601061"/>
    <dbReference type="KEGG" id="tpe:Tpen_0009"/>
    <dbReference type="eggNOG" id="arCOG02167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044992_0_0_2"/>
    <dbReference type="OMA" id="NLKGDCG"/>
    <dbReference type="OrthoDB" id="9990at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="329"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="467" mass="54803" checksum="EEA2C04AD23AE2E0" modified="2007-02-06" version="1">MSGGSCYTNTLEYLKHPLPAEVSELLRRGELRKAEGELRRLAETSPQPLAKRFEFELERIRRMGYEYPYTVEEAFRQLRKRVEDLTLEEFASLISRGCVDHAVIEGEVRVHRRFEPNAFWLCGDLSSRRKSLGDERSDLNELTLKWRAERVLSAAREKGGGYVLPLRYRVRARVSLKRSPRELGEPVRVWIPLPRVEGIHSEFRLLDYSVKPVHVAPPDHPQRTAYFELYGDTREVWVEYEFTSRGFHVEVDPREASVDPDSEVARRYLSERPPHIAFTGELREFVDRLTRGAASPYEKVQRIWGWITENVRYTYAKDYIFYDNIPEYVFREKRGDCGMQALLFITMCRIAGVPARWESGWYMHPLSPGMHDWAQFYLEPYGWLYADPSFGNKRKGGEWRNTFYLGSTEGYRLASNIEVYAEFDPPKRYIRSDPVDSQRGEVETPSRNLYYDEWDFALEIVSVEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW52</accession>
    <name>A1RW52_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751697.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0022"/>
    <dbReference type="EnsemblBacteria" id="ABL77432">
        <property type="protein sequence ID" value="ABL77432"/>
        <property type="gene ID" value="Tpen_0022"/>
    </dbReference>
    <dbReference type="GeneID" id="4600384"/>
    <dbReference type="KEGG" id="tpe:Tpen_0022"/>
    <dbReference type="eggNOG" id="arCOG02103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369599_0_0_2"/>
    <dbReference type="OrthoDB" id="67368at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="203" mass="21803" checksum="5CDA71B151824F74" modified="2007-02-06" version="1">MSTGSSKTYLSFLLFLYVSGGYVSRKTLSSELGLGEGVVRSHLRFLNERGLVRSVRAGNALTDSGRNGVRGLLEAMSAKRLGLAPAWELNAREAVYVLLHGYPPAENVVKLRDEAVREGADGAVIAVFDGGKFRLPPGGEDLCSYAPRLCGEVLGEAEEEDCLLVVFGERLGAAVKGLVGILLSEKAPWRPSLLESLELLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW83</accession>
    <name>A1RW83_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751728.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0053"/>
    <dbReference type="EnsemblBacteria" id="ABL77463">
        <property type="protein sequence ID" value="ABL77463"/>
        <property type="gene ID" value="Tpen_0053"/>
    </dbReference>
    <dbReference type="GeneID" id="4600533"/>
    <dbReference type="KEGG" id="tpe:Tpen_0053"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OMA" id="TRILMSM"/>
    <dbReference type="OrthoDB" id="15038at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="14"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="445" mass="47378" checksum="6515C6F146F54F38" modified="2007-02-06" version="1">MSRLKRELGLGYATLFGVGLILGAGIYVLIGRAAGIVGDAVWASVAFSGVIAVATAFSYAELSSIFAKAASTYTYVREAFPGAGLLAFFAAWMLFFGGVAGAATAALGFAGYFSRLAGLGEGWVVPVTVALLAVLSVLNWWGIKESAFLSAVFTVIEAGGLVLVVLLGFLFPARSPGYLSFNPSVDPVMAVLVGAAVFYFAYTGFEYQPTLSEETVDPERVIPKSIVLAVSVTTLLYLLVSLSVVRLMSWEELGASKAPMADAASRAWPPAFHLLMFIALFATTNTSLGFLVSASRLAYGLAEEGVAWSGFGRVDGWRRTPHVAVAFTGVLAALLVFATDYLPSVTGWRLSFGGQEYQLIDLVGKTASLAVLLAFFVVNAAVVALRRREGLSRRFRVPLNVGDFPVLPVLADILIAVFVALSFWDWIVWLSTALVAALGLLLYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB6</accession>
    <name>A1RWB6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar-phosphate nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0086"/>
    <dbReference type="EnsemblBacteria" id="ABL77496">
        <property type="protein sequence ID" value="ABL77496"/>
        <property type="gene ID" value="Tpen_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0086"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="GEGQWIF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="377" mass="41024" checksum="45BCD8D8335171FE" modified="2007-02-06" version="1">MRPLNEGYHKFMLKISGNPIFFYPLSSLLQAAGQRVILVVDREMQIDWVKEFLREKNYAHVEVRVQPGESLEDAFLTATKDVSDEWFLLVFGDVVAPPEALRMLMETYEESQRPSALVIPRAEMSTYGVAYLSGMSIKKVYPGGDVGDSSFVLGGAFVLPVQFLELVENGSGFFEALNTVVDKMGMDAALWTGSWVAVDYPWDLISALYEILGSSCKSVIHPGARVSPLAVLEGCVIVEEGAYIDHYAVVRGPAYIGRNVLVGKGAFVREYTSLEEGSTVGAFSEVKRSVLEPSATAGSYSLIVDSVLGPYSVAEPRTTVISEIRGEKRIARPLPLQGVLSKKRKLGVFVAPRGRIAAGSVVGPGVLIHGDGRVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB8</accession>
    <name>A1RWB8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751763.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77498">
        <property type="protein sequence ID" value="ABL77498"/>
        <property type="gene ID" value="Tpen_0088"/>
    </dbReference>
    <dbReference type="GeneID" id="4601655"/>
    <dbReference type="KEGG" id="tpe:Tpen_0088"/>
    <dbReference type="eggNOG" id="arCOG05710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117974_0_0_2"/>
    <dbReference type="OrthoDB" id="136686at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="164" mass="18333" checksum="C95AF95BEE50393C" modified="2007-02-06" version="1">MSSIPQLVEKIAGMVPGFRGYSGGSLSADDQLIRKKVSLILDEARLRVERLEFNVKRKNVSLGLRLDDLRIELMKASQLLKQPGASSPGKASIDDESLQRLLEEDLKLISTASRIFERVVALTPALEPKEFLEKVNEAISLVVEAENVIRERDNLLKRVLLETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC1</accession>
    <name>A1RWC1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-octaprenyl-4hydroxybenzoate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0091"/>
    <dbReference type="EnsemblBacteria" id="ABL77501">
        <property type="protein sequence ID" value="ABL77501"/>
        <property type="gene ID" value="Tpen_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0091"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046234_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="476" mass="52103" checksum="9831DAB36DCDEA1F" modified="2007-02-06" version="1">MSLKETLKLLESSDKLMRIGGELAPSIEIPWLSIQLSRETDKALLYDRVKGGALSLATNLFYGKLPLVLNAPSVERIIERAARVLHLLSTPAAQPTDKLGLLASLAWIADYYPTVKEAPGGAVRILQGYDVNLLEMPFLKHSREEEYPVLVNPIIVASSRATGDREIASQRVQVVDEKTMVLHVPRGSPLQFLIEKSSRSRSSLDVGILAGTVPALYPASLLTWLTPVDKILLAGVLSESKISVVKTEEGLVIPYPTEVAIIGELEPGDERPEGRMLYENGEVYGGSPMPVVHVKKILLSPSPVFYSSIIHPERSDVAQVYSLVASLLVLLMKSLAPEIQELRFLGHDAFRTVIAKVATHRRERLLSIGGEILFLSAAVNPYVDTVILVGPDVDVEDPTILAKVLLENVDPDRDIIHVDQADAELLPRSSRRGKVIVLANAPGARGASRVESKLEKTPESERLFLELTRKLRGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF8</accession>
    <name>A1RWF8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751803.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0128"/>
    <dbReference type="EnsemblBacteria" id="ABL77538">
        <property type="protein sequence ID" value="ABL77538"/>
        <property type="gene ID" value="Tpen_0128"/>
    </dbReference>
    <dbReference type="GeneID" id="4600713"/>
    <dbReference type="KEGG" id="tpe:Tpen_0128"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548172_0_0_2"/>
    <dbReference type="OMA" id="GVEANDN"/>
    <dbReference type="OrthoDB" id="127785at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="499" mass="54222" checksum="A83BAD888CB0D258" modified="2007-02-06" version="1">MLKEKFPGALLALVVVAVLGVASLAYAQPGKGNLTVYIDVFENGNASVKIVVSPGDKGFVQLALPRFEKVYACGGSASGYRVVNSTSGAYFYFNSTIYFAEKGSSLALCYNFPYAVLMSGSRGWFMSPLLWSSEPEVVVYVKLPLVKRITYESPSSVGVSGNYRVYVLSPLVEQYIGNRVVVEYDLQSSTPVDTILYSSGGSTITVKFPVYYRSIALKVRDVATSAIAELSLIAGLRPSNVTFVFYLPERSMGGISALGFVMGEDVNAGGKGPVNLNLALIRYAPGYLETTVIHELVHVYLGAAGVEANDNTRWFHEGMAQYVSILVAKKLGVNISEYESELNESAASYYNYTGGKIGFIENWPSDAVKEGEAYLASYYVVHTLATKYGGENFVKRVFATLQGRHITTTREIVNVLSQAAGTNLAPLFREWGFRDVEDWTPSNAKTPPSNSTSTPSSSSTGNSRFLIAMIALLAVIFIVTYVVNAVVERELRIAEHAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG4</accession>
    <name>A1RWG4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751809.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0134"/>
    <dbReference type="EnsemblBacteria" id="ABL77544">
        <property type="protein sequence ID" value="ABL77544"/>
        <property type="gene ID" value="Tpen_0134"/>
    </dbReference>
    <dbReference type="GeneID" id="4602177"/>
    <dbReference type="KEGG" id="tpe:Tpen_0134"/>
    <dbReference type="eggNOG" id="arCOG01210">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393049_0_0_2"/>
    <dbReference type="OrthoDB" id="140154at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="95" mass="11131" checksum="89EA5FD1E80932E1" modified="2007-02-06" version="1">MAEYIRLAKLLRELESLAPECRAFFRVLSLFLENPDEAFTKYRVEKETALSHVARVLERMVSMGVLEIVDENPRLYRLNKQSPFLQHLLEPLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI9</accession>
    <name>A1RWI9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751834.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0159"/>
    <dbReference type="EnsemblBacteria" id="ABL77569">
        <property type="protein sequence ID" value="ABL77569"/>
        <property type="gene ID" value="Tpen_0159"/>
    </dbReference>
    <dbReference type="GeneID" id="4601268"/>
    <dbReference type="KEGG" id="tpe:Tpen_0159"/>
    <dbReference type="HOGENOM" id="CLU_191163_0_0_2"/>
    <dbReference type="OrthoDB" id="141929at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="86" mass="9659" checksum="5AA87E96B38D661E" modified="2007-02-06" version="1">MAYERSAPRAPGKSVEECMKKMLESALRDQFNGVGRAFISSLLEQGFTRDEVSEAVRALSSQYEVRVIGDVVKVYFGKEKRSNAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ8</accession>
    <name>A1RWJ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62, modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751843.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0168"/>
    <dbReference type="EnsemblBacteria" id="ABL77578">
        <property type="protein sequence ID" value="ABL77578"/>
        <property type="gene ID" value="Tpen_0168"/>
    </dbReference>
    <dbReference type="GeneID" id="4601423"/>
    <dbReference type="KEGG" id="tpe:Tpen_0168"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="IRVGHAS"/>
    <dbReference type="OrthoDB" id="22382at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="118"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="241"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="481" mass="53534" checksum="ABC809B36893B643" modified="2007-02-06" version="1">MSWQYEDLVVKAVSHGEALGASYVEARYHLIARSGLSSRNGEVIGVEKSFSQGIAIRVIVDGSLGFASTSVLTPEGVTGAVEKAYKKAKAHAKLQKRPIEFSDERLGRVTYEAVEKKSPRDVDFQEKTRYHQELWKLVSGAISTARVATLTSFYGESVEEKIVVNSDGAYVKSRVPRVSLGYNVVVTLPSKGTIQRFFSHAASGGYELVDAWKVHEYLPEDVKTFEKILLEAKSPPVDRPVDVIVGSEIVGLMVHESCGHPSEADRIMGREAAQAGKSFIKPNMLGERIGSEYATVIDDPTIPGSNGFYLYDDEGVPARPRYLYKNGVINEFLHNRWTAKLFGTHSNAAARAMNHEGEPIVRMANTYFKPGDYTFEELLEDVKYGVYIKSYMEWNIDDERWSQRYGGLEAYLIENGELKGLVRNPVLELTTKTFYSSVDAADRNLEFYAGTCGKGEPMQGVPVWFGGPNVRVRNIKLRVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK4</accession>
    <name>A1RWK4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0174"/>
    <dbReference type="EnsemblBacteria" id="ABL77584">
        <property type="protein sequence ID" value="ABL77584"/>
        <property type="gene ID" value="Tpen_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0174"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_2_2"/>
    <dbReference type="OMA" id="VNGRHIQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12621" checksum="B80F8B95F177EB99" modified="2007-02-06" version="1">MFEAKSSRKKFLNLRRNSLHVRVHVKFLLFATLRDKYGVPEVSVDCDGSLRGCVEEAARILGRDFVEEVFEGDDYRRDRIILVNGRHIQFVQSTQLKDGDVVAVFPPIAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK5</accession>
    <name>A1RWK5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751850.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0175"/>
    <dbReference type="EnsemblBacteria" id="ABL77585">
        <property type="protein sequence ID" value="ABL77585"/>
        <property type="gene ID" value="Tpen_0175"/>
    </dbReference>
    <dbReference type="GeneID" id="4600877"/>
    <dbReference type="KEGG" id="tpe:Tpen_0175"/>
    <dbReference type="eggNOG" id="arCOG02187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044170_0_0_2"/>
    <dbReference type="OMA" id="CPDCRRY"/>
    <dbReference type="OrthoDB" id="93710at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DksA C4-type" evidence="4">
        <location>
            <begin position="366"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="455" mass="50231" checksum="BF67AC05AC3B37B5" modified="2007-02-06" version="1">MSVCVVRCRDFEGDVAGRLARILEDCEGVVLLGDSSCTERWAGIVEELRVRGARWYRLVYVDEERDPLLSSLSVDAVVDLWRKFLEETKDVAPEVKFEASKRVSRRELLSSGLGVLLTYTSIPAVDSSRCLTLRNCDVCLSSCPYDAMSGKPPKPDADRCVECGLCTSSCPSGLMFTPHIPPEKLRTLIKGARRGGCEALLVVCPKTRRLAYGDFGEASPRGFLIELPCVASLRIHEYLYAKALGMDVFLYAPSNVCSGCPRVSARDAFLSMVREADNITEKRAAEPTPGPLPAVFSHVSREDVNQWLSLEFLPIFRVSVKDSCTLCGACAKNCPEKALNAVASSGRVELRFYPWRCIGCRECVEVCPEDAVEIDRAANPALMSRHEHIVLSSSEMARCSKCGREIAPEKLVASLEAKMTRKGLPREVVSSLRICDECKRKSMVEELEKSLEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM8</accession>
    <name>A1RWM8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751873.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0198"/>
    <dbReference type="EnsemblBacteria" id="ABL77608">
        <property type="protein sequence ID" value="ABL77608"/>
        <property type="gene ID" value="Tpen_0198"/>
    </dbReference>
    <dbReference type="GeneID" id="4600807"/>
    <dbReference type="KEGG" id="tpe:Tpen_0198"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_0_2"/>
    <dbReference type="OMA" id="ICLMGET"/>
    <dbReference type="OrthoDB" id="92721at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="28053" checksum="CE1CD2DDCA3A708A" modified="2007-02-06" version="1">MRVLSLDQYRLILAEELKLRDGVLVQGLPGIGLVGKIAVDYIVSTLNLRKVAELIGPGIILPVGNVGVYVTNEGALQIPSYKFYLLNGGSRDILFVTSEAQPALWAQYEVAEKVLDFFVSIGGREVIGACGTTAEESEHVGVYYAYASEDCAKKLEALGAKRSTGGTITGACGLLPALAALRGLKAYVLMGSTQTPEPNFVAARELIRVLSKLLEFEVSLEDLEKTIEQIRRREEEMEKVLETARQKEGESLPSWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP4</accession>
    <name>A1RWP4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THUMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751889.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0214"/>
    <dbReference type="EnsemblBacteria" id="ABL77624">
        <property type="protein sequence ID" value="ABL77624"/>
        <property type="gene ID" value="Tpen_0214"/>
    </dbReference>
    <dbReference type="GeneID" id="4601807"/>
    <dbReference type="KEGG" id="tpe:Tpen_0214"/>
    <dbReference type="eggNOG" id="arCOG00084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097042_0_0_2"/>
    <dbReference type="OMA" id="TGWRQER"/>
    <dbReference type="OrthoDB" id="99764at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="PTHR13452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="63"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="190" mass="21660" checksum="875D461AC13B2848" modified="2007-02-06" version="1">MLGEFNLVVSTYRQRENDCISELWFFAKELGDSRLDASKTGLPSLVVAKTSLDPEDFVAKAREKIEENPWYFRYILKITPIQVTVDADIQQIVEAALRLSSSRLNPGETFKVEAHIRLSELRREDIIREIASRITNKVNLDNPDKIVLVEVIGDRAGVSVIPPSMILSVERARREAKARKHQSERLDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS9</accession>
    <name>A1RWS9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751924.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0249"/>
    <dbReference type="EnsemblBacteria" id="ABL77659">
        <property type="protein sequence ID" value="ABL77659"/>
        <property type="gene ID" value="Tpen_0249"/>
    </dbReference>
    <dbReference type="GeneID" id="4601476"/>
    <dbReference type="KEGG" id="tpe:Tpen_0249"/>
    <dbReference type="HOGENOM" id="CLU_598031_0_0_2"/>
    <dbReference type="OrthoDB" id="135899at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="457" mass="49758" checksum="F56CFB1CBB467E47" modified="2007-02-06" version="1">MKVLARGFLAALGAYTATRLFLALHGEPVNAFEFVPAVASLASPSLGSSLAALVPPLLLYLHGKYAFALIVLPLSLLFIFKVIQSWRSALIVSIASTTAVIDPQLLPVVLGILLAEVSSEDYREAFSTSLVFALALFTLKALHASSPGYVYSLYLPGGVYSDVVAQSTNPLSAASLFYLRLFELLASNAFLALTFFTLVASLVVASAAAEKTGWRGIALAAVILLIPAVTFPLDILRALVGVTEAVAVGVTLASIPGFSLSSIRYRLRRAKQSNEKKYPPSIAFADILRLARTDFFAQALSSAKNIVIYGPCVEDERVVLQAVLKGRIQGASVFLFHENREEEILTLDPERTVVLYVPPFSWEELRDVLSKATGFPADVIDGMSDLAKPKASLICRVDALRIAEKIQSLIDRGYTARKAFEEAFNACPAKINEEFFFILEHLYNRFKIVGFLAQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU8</accession>
    <name>A1RWU8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="9" type="ordered locus">Tpen_0268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5 7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751943.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0268"/>
    <dbReference type="EnsemblBacteria" id="ABL77678">
        <property type="protein sequence ID" value="ABL77678"/>
        <property type="gene ID" value="Tpen_0268"/>
    </dbReference>
    <dbReference type="GeneID" id="4601686"/>
    <dbReference type="KEGG" id="tpe:Tpen_0268"/>
    <dbReference type="eggNOG" id="arCOG04254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="80498at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="8">
        <location>
            <begin position="58"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="200" mass="22523" checksum="34E0E7E92329C9A2" modified="2007-02-06" version="1">MAEGDQYITTLDGNEIKVFDRWSTRDVEIRDPGLKKYISLKPVLVPHSEGRHAKKRFAKARVSIVERLANNLMRPGRNAGKKMLALNIVKRAFEIIELKTGKNPIQVLVWAIENASPREETTRVIYGGILYHVSVDVSPQRRVDLALRFITEGARACAFNNPKPIEECLADEIVAAAYGDPNSYALRKKEEVERVALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW2</accession>
    <name>A1RWW2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusA</name>
        <name evidence="7" type="ordered locus">Tpen_0282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751957.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0282"/>
    <dbReference type="EnsemblBacteria" id="ABL77692">
        <property type="protein sequence ID" value="ABL77692"/>
        <property type="gene ID" value="Tpen_0282"/>
    </dbReference>
    <dbReference type="GeneID" id="4602092"/>
    <dbReference type="KEGG" id="tpe:Tpen_0282"/>
    <dbReference type="eggNOG" id="arCOG01760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OMA" id="TDQIKYI"/>
    <dbReference type="OrthoDB" id="99842at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="6">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="149" mass="17089" checksum="15484D2DD04A4380" modified="2007-02-06" version="1">MTSEEGRRLTHEDLQIMNLFEEITKVPPKDIVYDDTFQRYIFLVDKGFAPLAVGKNGSKIRMIKELLRKDVEVVEDGSSLEDFVKSVFFPARVVEVKVREENNRKVVIAVVPPDQLGLAIGRNGRNVQRAKILLKRYYGADEVRVQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY1</accession>
    <name>A1RWY1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0301"/>
    <dbReference type="EnsemblBacteria" id="ABL77711">
        <property type="protein sequence ID" value="ABL77711"/>
        <property type="gene ID" value="Tpen_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0301"/>
    <dbReference type="eggNOG" id="arCOG04171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021627_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="122" mass="13751" checksum="4869E1DEE34B47CE" modified="2007-02-06" version="1">MKANKAARDLRPEAKEYLRSGQRVLLALVLPGQGLYDTFYARGHPDLTFTDRTSIVVRKSSYIDGRTIAVNSQKAAYEIDRRIIEEIKNPDAVLLLYILPGEASQSEVLEAIREDLDVDSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ8</accession>
    <name>A1RWZ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751993.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0319"/>
    <dbReference type="EnsemblBacteria" id="ABL77728">
        <property type="protein sequence ID" value="ABL77728"/>
        <property type="gene ID" value="Tpen_0319"/>
    </dbReference>
    <dbReference type="GeneID" id="4602087"/>
    <dbReference type="KEGG" id="tpe:Tpen_0319"/>
    <dbReference type="eggNOG" id="arCOG02959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_3_0_2"/>
    <dbReference type="OMA" id="HYDAHDI"/>
    <dbReference type="OrthoDB" id="63554at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="194"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="416" mass="46002" checksum="37C7A8E39E4174F4" modified="2007-02-06" version="1">MQSLDYEYAYRMAVLISERPRFTGTEGERTAREAIKEELEKHGYSVSLEKFSTKTYEVVESELVITEPYLGRVEASALGFSGETPAEGVEGELVYLENTDPVLIPEEDGWIGIVVQRPSKEGWQRLVKKAGGLVIAESTPYRGLSRVAVPYEWREKIGSLPSVYVKYRDAVRMLTARRARLKLTQVYRDVDTYNIIAEVKGYKYPDEIVYLTAHYDSVMGVPGATDNAGGTALLLALAKALAGFKPKRTVRFAFFAAEELGLRGSLFHVGSLNEEEKKKIKVVVNLDVHGGALGSSAAVISGPKSLRYFAEIHAKKLGVNLSISEDIMSSDGTSFVKHGIPAVNLYRSSGSGADIHTESDSPEHLHPLAFKVIGHYALHLVTELLSAEEIPFEREIPEEIKKKAEEYFAKRLGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX66</accession>
    <name>A1RX66_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752061.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0387"/>
    <dbReference type="EnsemblBacteria" id="ABL77796">
        <property type="protein sequence ID" value="ABL77796"/>
        <property type="gene ID" value="Tpen_0387"/>
    </dbReference>
    <dbReference type="GeneID" id="4602155"/>
    <dbReference type="KEGG" id="tpe:Tpen_0387"/>
    <dbReference type="eggNOG" id="arCOG01365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217189_0_0_2"/>
    <dbReference type="OrthoDB" id="140433at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="106" mass="11977" checksum="F837C3981A2455F1" modified="2007-02-06" version="1">MSRNRYVVLAFNAGKCASCTPTSILEEWIRALYGAWGASVIRLREVYSNNKGVYVYRINADSQKLFRSIFVLDADGVFYVIKTTGSLRKARSIADSINISFEDTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX72</accession>
    <name>A1RX72_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752067.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0393"/>
    <dbReference type="EnsemblBacteria" id="ABL77802">
        <property type="protein sequence ID" value="ABL77802"/>
        <property type="gene ID" value="Tpen_0393"/>
    </dbReference>
    <dbReference type="GeneID" id="4600528"/>
    <dbReference type="KEGG" id="tpe:Tpen_0393"/>
    <dbReference type="eggNOG" id="arCOG00328">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="OMA" id="GNQKSPY"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="33"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="377"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="794" mass="91049" checksum="C64C76BBA89E5116" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX74</accession>
    <name>A1RX74_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0395"/>
    <dbReference type="EnsemblBacteria" id="ABL77804">
        <property type="protein sequence ID" value="ABL77804"/>
        <property type="gene ID" value="Tpen_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0395"/>
    <dbReference type="eggNOG" id="arCOG04224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157709_1_0_2"/>
    <dbReference type="OMA" id="IPELEVW"/>
    <dbReference type="OrthoDB" id="126831at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="10420" checksum="972DF08BD7A74BF6" modified="2007-02-06" version="1">MVMAEQRRERRLRLRRRDEVPEGRAFMNPSTMNELGISSEIEVVIAGKKKLYFAAMPSESVPPNEVWCNTDELKTKGVADNSIATVRAKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX78</accession>
    <name>A1RX78_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752073.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77808">
        <property type="protein sequence ID" value="ABL77808"/>
        <property type="gene ID" value="Tpen_0399"/>
    </dbReference>
    <dbReference type="GeneID" id="4602112"/>
    <dbReference type="KEGG" id="tpe:Tpen_0399"/>
    <dbReference type="eggNOG" id="arCOG15014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217190_0_0_2"/>
    <dbReference type="OrthoDB" id="119671at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="106" mass="12082" checksum="683F660F381293DB" modified="2007-02-06" version="1">MSLSGVEKFLLSYVYYEYGGKLYFQSPGGDAESFLAEFIAEEFLPRKNPNFSRVVEGFASALRGLREKGYVELRGYELILTDSGKAVATQISQEEYRDLKKRFSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC1</accession>
    <name>A1RXC1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0442"/>
    <dbReference type="EnsemblBacteria" id="ABL77851">
        <property type="protein sequence ID" value="ABL77851"/>
        <property type="gene ID" value="Tpen_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0442"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575730_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="474" mass="55776" checksum="B420251F896172FA" modified="2007-02-06" version="1">MVEEYMKGDGAVTGRMRVELEVDEKTRETVEREARRRAQEAMEKIDRRYLEVYEYLARVARKLRKRWPWLSILTIYMLILLDKAYEQAKRFLDEYTRAQEYVVYKSGKTSWRVYPKGKDFYVQVARVPNGYFTAKLPLYGVSLKAFVKGPRLTRRERRSAIKGWLLSDASYKPETLQATTDQEWQVVAIATFFELLRLAIVALTIGEKTLRFTWHLDAPIKLNWNLKGKAKRAYVRKFVLRAKRGRLNPREYITLLFLYFGDGGLPGFERTCLQFIVGHRNICITGEKAVEIARRMLESVRRSGLGELLELLEVPKYEYLKVLADRKPNHVTRMHIEVSGVKMYLDLVGDPRYSFTLEARVYEGKRQRVPRNFSELAEKEGLKVKEFIVKIKCRNGKVYEYRAWRAYTEELLEFAHVHPQAYCVYLSFLYAKREKFKGDPQACRALERLIERIVEDARRHATNLACLEELGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG8</accession>
    <name>A1RXG8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ordered locus">Tpen_0491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752163.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0491"/>
    <dbReference type="EnsemblBacteria" id="ABL77898">
        <property type="protein sequence ID" value="ABL77898"/>
        <property type="gene ID" value="Tpen_0491"/>
    </dbReference>
    <dbReference type="GeneID" id="4601789"/>
    <dbReference type="KEGG" id="tpe:Tpen_0491"/>
    <dbReference type="eggNOG" id="arCOG04208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_0_2"/>
    <dbReference type="OMA" id="ISTGIWQ"/>
    <dbReference type="OrthoDB" id="122290at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="91" mass="10049" checksum="64ABF3CF640D5E0B" modified="2007-02-06" version="1">MGRHTRVVGPAGRFGARYGATLRKKVAAIERKMKARHKCPRCQAVGTVKRESIGIWVCRKCGYKFAGGAWLPRTEAGRTFSPEELKSMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK5</accession>
    <name>A1RXK5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752200.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0529"/>
    <dbReference type="EnsemblBacteria" id="ABL77935">
        <property type="protein sequence ID" value="ABL77935"/>
        <property type="gene ID" value="Tpen_0529"/>
    </dbReference>
    <dbReference type="GeneID" id="4601347"/>
    <dbReference type="KEGG" id="tpe:Tpen_0529"/>
    <dbReference type="HOGENOM" id="CLU_1302683_0_0_2"/>
    <dbReference type="OrthoDB" id="139712at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="249" mass="26548" checksum="1E057F99BD8A1A73" modified="2007-02-06" version="1">MYSGEVKRRRIIRSLERFAKEAGMSAFEKAEPPFDASAVDGSGVRVAFKIVSGAPGAEGSGATGSMFQRVKSAGATCADASYGKVYIVVDEEGWVKLTGYSLRREFEDEYKAGLLLVTEEGGVVEIIPAPLRTPSYKHPAALGGYSSESRAQQLPPPLGYSPTRDLSVGAEQARETRAVSVPGGEATGVSTGDLPSFARDNPWLRILSSGGAGRAEEKVPERGDESELPSFARDNPWLDFLSRRRGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM6</accession>
    <name>A1RXM6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77956">
        <property type="protein sequence ID" value="ABL77956"/>
        <property type="gene ID" value="Tpen_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0550"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="59" mass="6476" checksum="7EBA8AA35C9C6EAC" modified="2007-02-06" version="1">MASTLKGDGLYEARLVEALDAIEEFLASVRSAPARVEEDEELARELEEDVEELRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN4</accession>
    <name>A1RXN4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752229.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0558"/>
    <dbReference type="EnsemblBacteria" id="ABL77964">
        <property type="protein sequence ID" value="ABL77964"/>
        <property type="gene ID" value="Tpen_0558"/>
    </dbReference>
    <dbReference type="GeneID" id="4600601"/>
    <dbReference type="KEGG" id="tpe:Tpen_0558"/>
    <dbReference type="HOGENOM" id="CLU_2679130_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="74" mass="8279" checksum="79286F55C85428EE" modified="2007-02-06" version="1">MVERGALCGRATATFKARGVARLEASSDAEFLGKLIAAFVWAFVERFRVDEVKVFYPEDEVALATVRALEKLRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU8</accession>
    <name>PCNA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="1">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcn</name>
        <name type="ordered locus">Tpen_0624</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752293.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXU8"/>
    <dbReference type="SMR" id="A1RXU8"/>
    <dbReference type="STRING" id="368408.Tpen_0624"/>
    <dbReference type="EnsemblBacteria" id="ABL78028">
        <property type="protein sequence ID" value="ABL78028"/>
        <property type="gene ID" value="Tpen_0624"/>
    </dbReference>
    <dbReference type="GeneID" id="4601411"/>
    <dbReference type="KEGG" id="tpe:Tpen_0624"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="70433at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000072003" description="DNA polymerase sliding clamp">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <sequence length="247" mass="27583" checksum="8330327D2CBC98C1" modified="2007-02-06" version="1">MVKFVFPDAREWKYIIESLATIVDEANFVASPEGLKLRALDPGRIAMVDLFIPSNLFEEYSVDQETKISAVLDDIDKVLKRAKSDDKISFEVSQGRLIITLSGRAERRFKFPLIDIAGQELPSPKLNFTVAAKMLSDTFRDALKDASLVSESVKLKAEDESLWLLARSDKGEIESRFSIETGSLVEIDVKEAAEASYGIDFLDKIVSKAYRISDILGLRFATNMPLEMTFDIAGGGTLKYLLAPRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV8</accession>
    <name>A1RXV8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0635"/>
    <dbReference type="EnsemblBacteria" id="ABL78038">
        <property type="protein sequence ID" value="ABL78038"/>
        <property type="gene ID" value="Tpen_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0635"/>
    <dbReference type="HOGENOM" id="CLU_2766313_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="7733" checksum="E014E14D9394216B" modified="2007-02-06" version="1">MTLPTRVCAARAETKTAKSSQDSLFEHVSEDPELWEALYAFAKAEVKPVAEKLFEGLLKIRLLGALEKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW9</accession>
    <name>EF1A_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-alpha</fullName>
            <shortName evidence="2">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name type="ordered locus">Tpen_0647</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752314.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXW9"/>
    <dbReference type="SMR" id="A1RXW9"/>
    <dbReference type="STRING" id="368408.Tpen_0647"/>
    <dbReference type="PRIDE" id="A1RXW9"/>
    <dbReference type="EnsemblBacteria" id="ABL78049">
        <property type="protein sequence ID" value="ABL78049"/>
        <property type="gene ID" value="Tpen_0647"/>
    </dbReference>
    <dbReference type="GeneID" id="4601513"/>
    <dbReference type="KEGG" id="tpe:Tpen_0647"/>
    <dbReference type="eggNOG" id="arCOG01561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="13117at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000337612" description="Elongation factor 1-alpha">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="433" mass="48493" checksum="DFBB397034698897" modified="2007-02-06" version="1">MSEKKPHLNLVVIGHIDHGKSTLMGRLLYEIGAVDPRLIQQYEEEAKKMGRETWKYAWVLDKLKEEREKGITIDLGFYKFETKKYFFTLIDAPGHRDFVKNMITGASQADVALLVVSAKEGEFEAGISPAGQTREHVFLAKTMGVDQLVVAINKMDTVNYSKERYEEIKNQLIRLLRMVGYKVDEIPFIPTSAWEGVNVSKRTPEKTPWYDGPCLYEAFDFFKEPPRPIDKPLRIPIQDVYSIKGVGTVPVGRVETGVLKVGDKIIINPPKAVGEVKSIETHHTPLQEAIPGDNIGFNVKGVEKSQLRRGDVAGHTTNPPTVAEEFTGRIFVLYHPTAIAAGYTPVLHIHTATVPVTFEELLQKLDPRTGSVAEEKPQYIKQGDSAIVRFKPRKPVVVEKYSEFPPLGRFAIRDSGRTIAAGVVIDVKKAEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY13</accession>
    <name>A1RY13_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752358.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0691"/>
    <dbReference type="EnsemblBacteria" id="ABL78093">
        <property type="protein sequence ID" value="ABL78093"/>
        <property type="gene ID" value="Tpen_0691"/>
    </dbReference>
    <dbReference type="GeneID" id="4602005"/>
    <dbReference type="KEGG" id="tpe:Tpen_0691"/>
    <dbReference type="eggNOG" id="arCOG04312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155020_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14899" checksum="622FC6DB59116FA3" modified="2007-02-06" version="1">MCKKVLVDTSVFMYLAEKGLDLLDVLFEREDVCRVVVPSAVLSELKHLSLSSRGAKARRAKLALKLLEEVLKRHPKLFEVLDCEVGKDVDKSLVNLAFKEGYILATADRNLKKNALQAGVEVLFLRRSTGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY36</accession>
    <name>A1RY36_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752381.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0714"/>
    <dbReference type="EnsemblBacteria" id="ABL78116">
        <property type="protein sequence ID" value="ABL78116"/>
        <property type="gene ID" value="Tpen_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="4601595"/>
    <dbReference type="KEGG" id="tpe:Tpen_0714"/>
    <dbReference type="eggNOG" id="arCOG00188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="NVGHEEK"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="31547" checksum="2D88703D007E1E5C" modified="2007-02-06" version="1">MKSAVYMEGVSYKYPDSDTPALRDINFEADFGELVLLVGPSGCGKSTFARIFNGLIPNFYGGELTGRISIAGLDPRKTPTPKFAGLVGFMFQNPENQLFFNSVERELAFGLENLGIPPEEIRRRVDETLKEYGLEELRHRSPFELSGGQQQKVALASVMVMKPRILILDEPTANLDPLSAMRTLGIVAKKTREYNMLTILIEHRLEIALQFATRVVVMLDGRIVADGDPLDTVSKARHIVGTPFVVRLLEELKDAGFTPNVNRLVPETVATEVARWLLEGGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY48</accession>
    <name>A1RY48_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752393.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0726"/>
    <dbReference type="EnsemblBacteria" id="ABL78128">
        <property type="protein sequence ID" value="ABL78128"/>
        <property type="gene ID" value="Tpen_0726"/>
    </dbReference>
    <dbReference type="GeneID" id="4600846"/>
    <dbReference type="KEGG" id="tpe:Tpen_0726"/>
    <dbReference type="HOGENOM" id="CLU_2067939_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="13326" checksum="F1EBE7A657389582" modified="2007-02-06" version="1">MSQPRRPFAQQRGEDERQGKPSLPVPRVEVEEARPPKPADAEEELVRRGVEGLKAVLDAVGLDPGIAEKVKEKLRSIADEVARINERISALEQERGRLLAERERLLRLLKAFSEVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY87</accession>
    <name>A1RY87_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752432.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0765"/>
    <dbReference type="EnsemblBacteria" id="ABL78167">
        <property type="protein sequence ID" value="ABL78167"/>
        <property type="gene ID" value="Tpen_0765"/>
    </dbReference>
    <dbReference type="GeneID" id="4601087"/>
    <dbReference type="KEGG" id="tpe:Tpen_0765"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="EYMREYG"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="259"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="388" mass="40989" checksum="98AE7F63E68B21A8" modified="2007-02-06" version="1">MTGVYLVGIGATKIDEHWERPLRDLMLEASLKALRDAGLSKRDVEAIFVGNMSSGYLQGQEHLGSLLATWLGVPGVAANKVEAACGSGGAAFHNAFLAVKSGLYDCVLAVGVEKLTDATTPDATSALIMAEDQEYVAFAGFSFVALNALVYKAYMKKYGAKQEDIALFAVHDHKYAVNNPLAQYPRAVTLEEVLSSPMVADPLRLLESAPLGDGAAAALLCSEKKLKEVEKDVVIEVVGSALATDVLSLHDRADLTTLSATVKASRKAYAMAGIEPKDVDVLEVHDAFTVLGVIHLEDLGFAEKGAGWKLLKEGQLEKDGDLPTNTMGGLKARGHPVGATGIYQIYDIAVQLRGEAGKNQVDGAEVGLAQNVGGVGGTVSVNILKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY92</accession>
    <name>A1RY92_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752437.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0770"/>
    <dbReference type="EnsemblBacteria" id="ABL78172">
        <property type="protein sequence ID" value="ABL78172"/>
        <property type="gene ID" value="Tpen_0770"/>
    </dbReference>
    <dbReference type="GeneID" id="4601092"/>
    <dbReference type="KEGG" id="tpe:Tpen_0770"/>
    <dbReference type="eggNOG" id="arCOG14782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131658_0_0_2"/>
    <dbReference type="OrthoDB" id="134688at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="248" mass="27027" checksum="0083FC7940666227" modified="2007-02-06" version="1">MSELRVAVALRAYSEESFESVQASLGAISSLDVPVQLSTEWSLIESLGVGEILDPFHDSGVSVSAIRVPYPLRVDAFLLEKLVMVAEETEGKTIILRDVAALSMGGLRRIADLCATYKVRALLEPSSGVEASRLYGLVKRLIGGIVGFSHVEENYPSTESFLKTVLAYLGITRNVTLSNYDADGRPAPIMAPKKYNNPLLVRRLVEGGFEGTLTISYEKSPVEEPGMLAGEVAALKEYVRGVYERTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY93</accession>
    <name>A1RY93_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0771"/>
    <dbReference type="EnsemblBacteria" id="ABL78173">
        <property type="protein sequence ID" value="ABL78173"/>
        <property type="gene ID" value="Tpen_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0771"/>
    <dbReference type="eggNOG" id="arCOG13405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754805_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="148" mass="16064" checksum="5B327355395223AC" modified="2007-02-06" version="1">MAYGVHCALVLILCCTITAYMEGRIDLRITEKGVIAVLPPRRGKLLEEILSRGLGELLADDTVLLRAESLEDAVAMLIELGVREDELAVEGKSVGFKAEVTRKHGVLVCPNCGSPDLERIGIPGLTPTLYVCRKCGFATYLPLEVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA5</accession>
    <name>A1RYA5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase, FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752450.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0783"/>
    <dbReference type="EnsemblBacteria" id="ABL78185">
        <property type="protein sequence ID" value="ABL78185"/>
        <property type="gene ID" value="Tpen_0783"/>
    </dbReference>
    <dbReference type="GeneID" id="4601131"/>
    <dbReference type="KEGG" id="tpe:Tpen_0783"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OMA" id="IGVHMDR"/>
    <dbReference type="OrthoDB" id="115808at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="375" mass="40273" checksum="390D7E1F3AD20EA6" modified="2007-02-06" version="1">MDVLVLGGGPAGLQLARFLKGYGDGDVYVYEEHERVGLPQHCTGLVSIEGLRKWIGVGERGLVLNRFRGARFVSPSGKVFLARRGSEVAAIIERKLLEEKLYEEAVSAGARVLLGARQTLGGFALSVRKRGAIGVIAGGTGFLSVLHGEKREFLLPALQLDVRVEDEVGDTDHLYVFLGEKFSRGLFAWAIPLEDGTYRVGLASRGNVLLRLKYLMLALSRVGVKVVKRLRVFGGAVYTGGMVDVYAGDRLFLLGDSAGQTKPTTGGGLVYLSIAARALSDAILSDRPEAYGEAVKRALGREMHVQLLVRKALNSLSDAELDELFQALKEVGGEEIVASEGSMDVQSAVALKLSAKLFLSRPTLLASAALKSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG1</accession>
    <name>A1RYG1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752506.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0840"/>
    <dbReference type="EnsemblBacteria" id="ABL78241">
        <property type="protein sequence ID" value="ABL78241"/>
        <property type="gene ID" value="Tpen_0840"/>
    </dbReference>
    <dbReference type="GeneID" id="4601549"/>
    <dbReference type="KEGG" id="tpe:Tpen_0840"/>
    <dbReference type="eggNOG" id="arCOG04756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961784_0_0_2"/>
    <dbReference type="OrthoDB" id="107586at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="293" mass="30577" checksum="FAB4AED6EFD1AB34" modified="2007-02-06" version="1">MIKELLDVYVPIASGLAFGYLSRPGEGELRLFARTVLYVFLTPLLFTSTYQRLSSSPASAPLALTALSASLVVLTFAIATKLHGDPELVLASMYANAGYIPLGIAQSYWGSYGASAVGFYILGNNFASNILAPLALGGESGRLSPRKVLAFPPVYAILAASALALAGVKLPELLLSPLATLGGVAPTVALVQLGMEVGASVDANIVDGLKAYFTRLSVSVPLTLLFVEAGLATGIDAKIAIVESVMPSAVSCVVISRELKLDSRRVAGVVFTSTLVSTLLALPVTLWLLSFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK1</accession>
    <name>A1RYK1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpiA</name>
        <name evidence="4" type="ordered locus">Tpen_0880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752546.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0880"/>
    <dbReference type="EnsemblBacteria" id="ABL78281">
        <property type="protein sequence ID" value="ABL78281"/>
        <property type="gene ID" value="Tpen_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="4600823"/>
    <dbReference type="KEGG" id="tpe:Tpen_0880"/>
    <dbReference type="eggNOG" id="arCOG01087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OMA" id="IPVYAQH"/>
    <dbReference type="OrthoDB" id="60670at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="227" mass="23737" checksum="778FADB26CA4291A" modified="2007-02-06" version="1">MKIGYPLILINFKAYSEASGKRGLQLAKVAEKVSKETGITIAVAPQLTDLAFIASQVEIPVFSQHVDDVPPGSYTGHVTLEAVKDAGAVGTMVNHSERRVRADQVDVIVKRARSLGLTTVVCTNTPEVTAAMAALGPDMVAIEPPELIGTGIPVSKAKPEVVTSSVELVKKVNPNVKVLCGAGITVGEDVAAALRLGTVGVLLASGVVKAKDWEKAILDLISPIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK3</accession>
    <name>A1RYK3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752548.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0882"/>
    <dbReference type="EnsemblBacteria" id="ABL78283">
        <property type="protein sequence ID" value="ABL78283"/>
        <property type="gene ID" value="Tpen_0882"/>
    </dbReference>
    <dbReference type="GeneID" id="4600825"/>
    <dbReference type="KEGG" id="tpe:Tpen_0882"/>
    <dbReference type="eggNOG" id="arCOG04112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="87520at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="340" mass="36908" checksum="1E2D3A366CA218BB" modified="2007-02-06" version="1">MEAGLSVGGYEVDLRPVREIRKLGARRVLLQAPDGLKHVARELAARLAADGVEAYVSGGHAWGGCDVALQEARAINADAILHLGHHGFVGARVDAPPVIFVPVYYEGLLFETFEKVVRNVALKGYRRVTIGTTYQHAKYFSRLVRLAEDAGLTVAGRHLDGYLGLVVGCNYAALAEDAEAVIVVAGGVFHALGAALWTGAPTWRVDPYTGDYGPVDVKPIVARRLRDLSRAIEARSFLVAVSSKTGQRRPEIARRIRDLLAERGLRAELAVFDEVTREGLLNLGSYDAYVNTACPRLAVDDPDLFPGPVVNPGELKYVLKGSLEGYSPRDLFRFDVLAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK4</accession>
    <name>A1RYK4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease IV</fullName>
            <ecNumber evidence="2">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752549.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0883"/>
    <dbReference type="EnsemblBacteria" id="ABL78284">
        <property type="protein sequence ID" value="ABL78284"/>
        <property type="gene ID" value="Tpen_0883"/>
    </dbReference>
    <dbReference type="GeneID" id="4600826"/>
    <dbReference type="KEGG" id="tpe:Tpen_0883"/>
    <dbReference type="eggNOG" id="arCOG01894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068832_0_0_2"/>
    <dbReference type="OMA" id="HIHISGI"/>
    <dbReference type="OrthoDB" id="51470at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="291" mass="32641" checksum="58AC04E6215784D4" modified="2007-02-06" version="1">MWKPDKLYFGPAGIPTTVSKGGVKEGMLEVKRLGLDAMEIEFVRKIFLDDKSAQEVKKLRHELEIVLTVHAPYYVNLNSADESKVKASAERVLRSAEVGFKAGAWSVCFHAGYYGDSEPESAYARIKSEVAAIARQLRDEGVEIWLRPEVLGKPSEFGSLEEVIRLSEEVENVLPTIDFAHLHARGKGALRQYQDFAAVLDALESRLGRIALDNMHIHVSGIEYGEKGEIRHLNLTEADLDYKLLVKVLRDYNVKGVVISESPNLEQDALLLKELYYGGARTSKRKRSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK7</accession>
    <name>A1RYK7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752552.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0886"/>
    <dbReference type="EnsemblBacteria" id="ABL78287">
        <property type="protein sequence ID" value="ABL78287"/>
        <property type="gene ID" value="Tpen_0886"/>
    </dbReference>
    <dbReference type="GeneID" id="4600829"/>
    <dbReference type="KEGG" id="tpe:Tpen_0886"/>
    <dbReference type="eggNOG" id="arCOG00398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117042_0_0_2"/>
    <dbReference type="OrthoDB" id="112460at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="197" mass="22300" checksum="9EAB8F01D4EF22BA" modified="2007-02-06" version="1">MSEHANTFNRKLGRTLRFKAKYIDMLLSGEKVTTIRRGIVTPTRDEVFLESDGKIYGTARVKSVRYTKVSELNSDDAVRDGFADKEDLKKALKEIYPDLKDDEWVTIIFLEDVNRFSSPLPLEALQRDIDFERASRIAQLALAHGVLNEKLARQVLARVALSGDVKDAARKLGVDENKVKIILAKAVEELRKRGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN3</accession>
    <name>A1RYN3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752578.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0912"/>
    <dbReference type="EnsemblBacteria" id="ABL78313">
        <property type="protein sequence ID" value="ABL78313"/>
        <property type="gene ID" value="Tpen_0912"/>
    </dbReference>
    <dbReference type="GeneID" id="4602125"/>
    <dbReference type="KEGG" id="tpe:Tpen_0912"/>
    <dbReference type="eggNOG" id="arCOG00161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_8_2"/>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="OrthoDB" id="100006at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="256" mass="28082" checksum="7AD1F7AC4A6CF2B8" modified="2007-02-06" version="1">MRGESLGVRLAALVPVLYVASTFYFPIVLMLFESLRGGGVSVYYQVVTNEDYLAIIAYSGLIAVIVTAVTLLASLPVAYYLAFYVESEEGKSKLLVAFTLPMLVNFLLRAYALMNIFSLLGLANSFQAVVIGMVYEYFPLMLLPVYSTFERVERRLLEAAETLGAKPHQAVLRVLVPVSAPGILSGVTLVFLMAFTEFVVPAMLGGVYGYTVGYLVWDLFLKYRNWAAGSALALIITAASLLAVYAYMRWGAELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR0</accession>
    <name>A1RYR0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752605.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0940"/>
    <dbReference type="EnsemblBacteria" id="ABL78340">
        <property type="protein sequence ID" value="ABL78340"/>
        <property type="gene ID" value="Tpen_0940"/>
    </dbReference>
    <dbReference type="GeneID" id="4601069"/>
    <dbReference type="KEGG" id="tpe:Tpen_0940"/>
    <dbReference type="HOGENOM" id="CLU_1567258_0_0_2"/>
    <dbReference type="OrthoDB" id="137211at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="170" mass="19000" checksum="B88545FC845D8E65" modified="2007-02-06" version="1">MDALASRVEEELKSRLAEVVRESLRRVELQRVEGTYVYARNYDLLKYRVAKAIASSLSVIDCLEGVYYADIASGEYITGQVYFGRDVDVIVLLDEGGCPWAPGLLKRVERVANAVIAEVAKREGAGWLADIAETNGVVEIHFDDIYVKMVRDKKSRGSLSDLNVIEVTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR6</accession>
    <name>A1RYR6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0946"/>
    <dbReference type="EnsemblBacteria" id="ABL78346">
        <property type="protein sequence ID" value="ABL78346"/>
        <property type="gene ID" value="Tpen_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0946"/>
    <dbReference type="eggNOG" id="arCOG03870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902039_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="15906" checksum="A11FA23224274B73" modified="2007-02-06" version="1">MVRVEGFASPRAGQAETIGAILLVVVAVAVWAAAWGFFYPVYQQLSQRVERERLVAEKGLREYLLLERLYVDQGKVCAYITNTGDVETELVSLYFNDTLVWSGYLDLKVGQSAQVCTPLTSKGTYRVKACSYTGCFEGVDYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS6</accession>
    <name>A1RYS6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Water Stress and Hypersensitive response</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752621.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0956"/>
    <dbReference type="EnsemblBacteria" id="ABL78356">
        <property type="protein sequence ID" value="ABL78356"/>
        <property type="gene ID" value="Tpen_0956"/>
    </dbReference>
    <dbReference type="GeneID" id="4600760"/>
    <dbReference type="KEGG" id="tpe:Tpen_0956"/>
    <dbReference type="eggNOG" id="arCOG03788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792226_0_0_2"/>
    <dbReference type="OMA" id="RIDIPPN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEA_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="144" mass="15650" checksum="F04B59476ECAEFA4" modified="2007-02-06" version="1">MRKALLLAVAVAAALAAFAYVQFEQRKAFENCKLTLVDVRVSELGLTSAKLTLVIDIYNPGSITATLDRAEFDVYADGTYLGHGTIPQRIDIPPNATRRISVPFEASYAGVLSVLKGQRTWTIKGTAYIDTPFGAIAVPFEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV1</accession>
    <name>A1RYV1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752646.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0981"/>
    <dbReference type="EnsemblBacteria" id="ABL78381">
        <property type="protein sequence ID" value="ABL78381"/>
        <property type="gene ID" value="Tpen_0981"/>
    </dbReference>
    <dbReference type="GeneID" id="4600455"/>
    <dbReference type="KEGG" id="tpe:Tpen_0981"/>
    <dbReference type="HOGENOM" id="CLU_1280856_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="215" mass="24466" checksum="82905748C48F7284" modified="2007-02-06" version="1">MVGRLPIKPFRKGTARYPRRRAERINTSGADKSRVRPESLYKLAGRVSAALTKLYELSEKEEKGGEYKVREEFRAKPLKAGEKPGLSFSMEDLEDEEVLEELKEYAEWRARNDEVRVTRFKYPAIAISWSGFGIACGPTSFSIEYYVVLKPEEKGAKVTAVMWDDEAGFMINELGFLEVEDEEKAAKELLNLIVKHVLPLTENPELVEKAFKEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV8</accession>
    <name>A1RYV8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752653.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78388">
        <property type="protein sequence ID" value="ABL78388"/>
        <property type="gene ID" value="Tpen_0988"/>
    </dbReference>
    <dbReference type="GeneID" id="4601964"/>
    <dbReference type="KEGG" id="tpe:Tpen_0988"/>
    <dbReference type="HOGENOM" id="CLU_1850740_0_0_2"/>
    <dbReference type="OrthoDB" id="130701at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="147" mass="16523" checksum="1C551B53488193E4" modified="2007-02-06" version="1">MRDFANEGEVYRFLRWKLRELWGARVEERYGLGRLSPDVDLLVVAGGGVFGLEVKYFQDRPLRAYEGLGEALALLLYCFDGVYLVHVFDSSLRGVYGEVVERALRLVDLTPLGYVVVVGRGDPEVLRVPRGNPFKLRGECEAVGQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ37</accession>
    <name>A1RZ37_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752732.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1068"/>
    <dbReference type="EnsemblBacteria" id="ABL78467">
        <property type="protein sequence ID" value="ABL78467"/>
        <property type="gene ID" value="Tpen_1068"/>
    </dbReference>
    <dbReference type="GeneID" id="4601646"/>
    <dbReference type="KEGG" id="tpe:Tpen_1068"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2178020_0_0_2"/>
    <dbReference type="OrthoDB" id="116096at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="12828" checksum="F4D957DA31134B9A" modified="2007-02-06" version="1">MEFKVTEVATSGVRISIVDGREVAHCYIYLIKNDLHPEPYALLEDVYVDEEYRGRGIGTELVKKAIEVARSMNCYKIIATSRFEREAVHKWYEKLGFKRYGYEFRLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ42</accession>
    <name>A1RZ42_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Respiratory-chain NADH dehydrogenase, subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752737.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1073"/>
    <dbReference type="EnsemblBacteria" id="ABL78472">
        <property type="protein sequence ID" value="ABL78472"/>
        <property type="gene ID" value="Tpen_1073"/>
    </dbReference>
    <dbReference type="GeneID" id="4601651"/>
    <dbReference type="KEGG" id="tpe:Tpen_1073"/>
    <dbReference type="eggNOG" id="arCOG01546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="MYVGMGI"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="35261" checksum="9C653FC486D35A87" modified="2007-02-06" version="1">MLDIVLGVLVFPGLLFTVAMGFWFEYLERKVTARIQRRVGPLYAGPHGLLQPVYDFFKLLLKEEIVPGWTDVFTFRVAPILAVTIPVFGMCVLPVASTKGLLSFEGDFALVFLLLALGVLTLSLTGYSVLSPYTAIGVGRLLVQYSMYEGVFLLSLASAALQAKTMSFEGILAYQESHGFLGLYQPVSLAAALVALLAKLEKRPFDLPHAKQEVVAGWMTELSGRGLAFMRLYEDLSMVWGIALIVVVFLGGPLGPGYKELGALAGFAWFALKSLIVALAVILVSATTSRVRVYGLAEVFWKRVYPLVLLQLVVAFLLGWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ43</accession>
    <name>A1RZ43_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1074"/>
    <dbReference type="EnsemblBacteria" id="ABL78473">
        <property type="protein sequence ID" value="ABL78473"/>
        <property type="gene ID" value="Tpen_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1074"/>
    <dbReference type="eggNOG" id="arCOG10987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773302_0_0_2"/>
    <dbReference type="OMA" id="GLWFVEE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="15453" checksum="BB2FE482CEA9D1EC" modified="2007-02-06" version="1">MIEELLSVLGAVIIVGALYSKRVSLSLLLLSLGTVLVAMSIGLLVGATAGILVATVFAGALVALLSLWLIVTEKEEARADSIYVVAAVFFVLITVAFAVLLAFAYRLSPVPVILRKFTAEDAYLLLTLLLVSVTSSIYVLRGDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ64</accession>
    <name>A1RZ64_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752759.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1095"/>
    <dbReference type="EnsemblBacteria" id="ABL78494">
        <property type="protein sequence ID" value="ABL78494"/>
        <property type="gene ID" value="Tpen_1095"/>
    </dbReference>
    <dbReference type="GeneID" id="4600962"/>
    <dbReference type="KEGG" id="tpe:Tpen_1095"/>
    <dbReference type="eggNOG" id="arCOG08627">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030011_5_0_2"/>
    <dbReference type="OMA" id="IVFCTAH"/>
    <dbReference type="OrthoDB" id="114618at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="415" mass="45049" checksum="8DA59634F9B2D3AE" modified="2007-02-06" version="1">MAAIGVALGAVPITPSPPAGHELAGYIARQGRSLGAHDDVEARCMLIDWQPAVLLVNLDLLGVDSGIVETVHRVAEREVGAVEVVVSATHTHSAPATLFTNPLLTFGGSFLRRDYLAYFEERLRILFQDLAGRVERHDVLVGKGSVSGVVTDREDPGRKVDDEALVVVFKRGLQTAGYLLNYAVHPTVLGPDNLLISKDLVDPVLRYLGAAWKAGVGLFLNGAAANVSTRFTRRGQTFEEAERLGKLLVDQLLLLPLRGMPGDAAEVDLQAKRVSVSFRQPSPEELSAALRVGAGSAHPRVREAILEGVKALERITPYLSSAGRSEVELRVLRIGSLRLLFAPFELHSDFSLRLKRFAGSGKLGLVGYSGEYLGYLVPRDYALGYESVMQVLDEESSERVLRGLEEVLDFDPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ71</accession>
    <name>A1RZ71_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752766.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1102"/>
    <dbReference type="EnsemblBacteria" id="ABL78501">
        <property type="protein sequence ID" value="ABL78501"/>
        <property type="gene ID" value="Tpen_1102"/>
    </dbReference>
    <dbReference type="GeneID" id="4600969"/>
    <dbReference type="KEGG" id="tpe:Tpen_1102"/>
    <dbReference type="eggNOG" id="arCOG00031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086256_1_0_2"/>
    <dbReference type="OMA" id="KGYHQAS"/>
    <dbReference type="OrthoDB" id="114762at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="108"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="250" mass="27343" checksum="218BD0768B8714ED" modified="2007-02-06" version="1">MPISRSEAEVPRILASRVLRSLKSYVPLQEVYRALREEKVEVSPSELSRYAAGHSLPPSLKAVHILVALKRRGLLREILSKKISMDENGVVNVAQLAYDVEVLSAAVASAYPTFFRGVDVVLTAAVNGIPLASFAAWALDARLAVARRERESPSMKYLTAYLFQRDPPSVVPLYVPSSLLERGARVLIVDDLLRTGRTLKALLSLIDEADAEPVGVLALVSLSEAWKSVLTRDIQTMVILELASQGSTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ77</accession>
    <name>A1RZ77_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1108"/>
    <dbReference type="EnsemblBacteria" id="ABL78507">
        <property type="protein sequence ID" value="ABL78507"/>
        <property type="gene ID" value="Tpen_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1108"/>
    <dbReference type="eggNOG" id="arCOG10919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808030_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="342" mass="37245" checksum="06DD036791B5FF95" modified="2007-02-06" version="1">MISSEVCGVFDAEKAAREVVEEFGPRLDLTKPVEGLLPGGEARVFRVDLDVAADVYILDTPQGARIASMPEIVGARLSAEAFSLAEVAAKLVLRLAGSEELMFLHVLRGSPGYMLHEALAKAGARLREGFVKITSHSQHGEGNVTFSSVGAFTKGSDTLVVADTVATGATLEATVNFTLKIAEIKGINLRRIIVYGFIAEEGLRRLASLAEKVGLDAKFIAMQDVAALASNRFDMPLYGPDGKGGKVLGGIVDERTLRDMVGEYFPGMDQPGDWSERQCLLFNGEGLERGRIPGHLERSRAKLEELRSILAERGWYPDWLEEVYRKRVDGLERASSEEYCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ83</accession>
    <name>A1RZ83_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactokinase</fullName>
            <ecNumber evidence="8">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752778.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1114"/>
    <dbReference type="EnsemblBacteria" id="ABL78513">
        <property type="protein sequence ID" value="ABL78513"/>
        <property type="gene ID" value="Tpen_1114"/>
    </dbReference>
    <dbReference type="GeneID" id="4600856"/>
    <dbReference type="KEGG" id="tpe:Tpen_1114"/>
    <dbReference type="eggNOG" id="arCOG01029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_2"/>
    <dbReference type="OMA" id="NTHQDYK"/>
    <dbReference type="OrthoDB" id="65810at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="7">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="304"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="382" mass="42242" checksum="F9A65A7478CDA066" modified="2007-02-06" version="1">MAGGRFTASAPGRVDFLNTHQDYKGLPVVPVAINLRTYVDVLGRSELFEVKSEALCAEGLECVDRFPPTNPPLVEGRWWGNYLRAVVRAVEEYLGKPLPEGFRAVVRSEVPVGSGLSSSAALEVSFLKAIDYYFNLGLGKKELAELAFQAENRIAGIPCGRLDQYASAYGGVILLKPRPPVEVEELEPGSLRFVVVDSGIRHSVADIHPKRQEEINRGLRALMEDPSVPPGLKRLLGYRYDEPRWEELSLEDLQPYLDRLDEASRKRILFTLLMQASTSRAVGILRRKGWKPRELAPEVNYQHELLRDLYEVSLPELERIRDAMLRSGALAAKISGAGMGGSLLALTEGGEEEVVGSALREGGKKAWILVPDEGARIDRVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ90</accession>
    <name>A1RZ90_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752785.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1122"/>
    <dbReference type="EnsemblBacteria" id="ABL78520">
        <property type="protein sequence ID" value="ABL78520"/>
        <property type="gene ID" value="Tpen_1122"/>
    </dbReference>
    <dbReference type="GeneID" id="4602017"/>
    <dbReference type="KEGG" id="tpe:Tpen_1122"/>
    <dbReference type="eggNOG" id="arCOG01500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_1_1_2"/>
    <dbReference type="OMA" id="EKCTWCY"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="187" mass="20657" checksum="DC4684DDA1D7AC59" modified="2007-02-06" version="1">MRLAHLWDQSRCIGCGACIAACNAANYRSTTKDNPTWGGVQTNIKRIVFDLKEKPYILLVQCQHCENAPCVAVCPTGASYIDRDGLVKINPDLCIGCKYCMTACPYGMRWLDPDFGLPEKCMGETCQSRVKAGLMPVCVTVCPAGARAFGDLDDPNSEVNKRLKKGRVVRLLEYKGTRPKFFVVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA0</accession>
    <name>A1RZA0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752795.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1132"/>
    <dbReference type="EnsemblBacteria" id="ABL78530">
        <property type="protein sequence ID" value="ABL78530"/>
        <property type="gene ID" value="Tpen_1132"/>
    </dbReference>
    <dbReference type="GeneID" id="4602027"/>
    <dbReference type="KEGG" id="tpe:Tpen_1132"/>
    <dbReference type="eggNOG" id="arCOG01197">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_4_2"/>
    <dbReference type="OMA" id="NEEWENP"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="114" mass="12504" checksum="AB9D2CCAD11CB5A5" modified="2007-02-06" version="1">MGKAPSALRSQEKALEVAKRVAGRAAKLCEGRGFKLVGAYLVGSRARGDYLETSDVDLVLVVEGVEGLNALQRLELFKEVLEPEVDLLVLSPEEWREGRSAWVETLKKEAVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA9</accession>
    <name>A1RZA9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase domain protein, FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752804.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1141"/>
    <dbReference type="EnsemblBacteria" id="ABL78539">
        <property type="protein sequence ID" value="ABL78539"/>
        <property type="gene ID" value="Tpen_1141"/>
    </dbReference>
    <dbReference type="GeneID" id="4601396"/>
    <dbReference type="KEGG" id="tpe:Tpen_1141"/>
    <dbReference type="eggNOG" id="arCOG02017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_3_2"/>
    <dbReference type="OMA" id="WAMPLDF"/>
    <dbReference type="OrthoDB" id="76604at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="183" mass="19533" checksum="9E31A65DA1ECD1A5" modified="2007-02-06" version="1">MQGVGYVEVELRRHTRLLHPKLVALIVSVDASGRPNFMPAAWLTPVSVKPPLVAVAVAPERYTYSLVKSSGVFTVNPVDAGMLRVVEEAGSVSGRDVDKASSLGVRFLPALRVGAPCIEGALACLECRLWAEYPAGDHSILVGEVQAARARRDAWSGAVYDLAKARLLLHLGGDEYATASRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC8</accession>
    <name>A1RZC8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydroorotate oxidase B, electron transfer subunit</fullName>
            <ecNumber evidence="6">1.3.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1160"/>
    <dbReference type="EnsemblBacteria" id="ABL78558">
        <property type="protein sequence ID" value="ABL78558"/>
        <property type="gene ID" value="Tpen_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1160"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_2"/>
    <dbReference type="OMA" id="RYMKCGI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="266" mass="28663" checksum="7F4D3D190DE0B2DA" modified="2007-02-06" version="1">MGYTRARVAEVLDLAPSVKMYILELSRPFGSQPGQYVMVWLPGVGEFPVSVAGEKGGALRLVVARKGRATGYMHERVAEGGYVFVRGPLGRGFRLDARKALLVGGGYGAAPLLYLAERLSGAGATVHAVLGFRSREHALLVEDFRRVAGEVWVATEDGSEGFKGTAVDLFERVFPGGGYDAVYTCGKELMMEKVVRRAVEAGVRVQASLERIIKCGVGVCGACALEPLGLRVCSDGPVFDGETLLSLEDFGRYWRDHSGRRVPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC9</accession>
    <name>A1RZC9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="8">DHOD</shortName>
            <shortName evidence="8">DHODase</shortName>
            <shortName evidence="8">DHOdehase</shortName>
            <ecNumber evidence="8">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pyrD</name>
        <name evidence="10" type="ordered locus">Tpen_1161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="8">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752824.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1161"/>
    <dbReference type="EnsemblBacteria" id="ABL78559">
        <property type="protein sequence ID" value="ABL78559"/>
        <property type="gene ID" value="Tpen_1161"/>
    </dbReference>
    <dbReference type="GeneID" id="4602163"/>
    <dbReference type="KEGG" id="tpe:Tpen_1161"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_1_2"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="OrthoDB" id="31316at2157"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="9">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="31165" checksum="BD6B79E3312713F3" modified="2007-02-06" version="1">MVELSVEVAGLRLRNPVVVASGVLGVSVGLMKRAEDAGAGAVTSKTVTLNPREGYPNPVVYELDYGLVNSMGLPNPGAEEMGRILREARRVLGIPVIASIGASTPDEALRIAEALEGFDALELNASCPHVKGLGADLMSDPDAVYGIVSALKSSGYRVFLKLSPHGDYLAVARKAYSAGVDGFTAINTAKAMVIDVYARKPVLGGVVGGLSGRAIHPIAVRVVYELHREFPEVPVIGTGGVEGWVEAVELILAGASAVGVGTALKRGFEVIGEILGGIERYLRDEGFPSVESIVGLAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD3</accession>
    <name>A1RZD3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752828.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1165"/>
    <dbReference type="EnsemblBacteria" id="ABL78563">
        <property type="protein sequence ID" value="ABL78563"/>
        <property type="gene ID" value="Tpen_1165"/>
    </dbReference>
    <dbReference type="GeneID" id="4601179"/>
    <dbReference type="KEGG" id="tpe:Tpen_1165"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="TETYVYG"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="363" mass="40668" checksum="79AC18652F86D0A6" modified="2007-02-06" version="1">MARVAVKDLVKRFGKVVAVDRVSFEAKDGEFLVLLGPSGCGKTTTLRMIAGLETPDEGEIYIGDRLVNDLPPKDRDVAMVFQNYALYPHMKVYDNIAFPLRIRKLPADEIDRRVREVAKLLRIEELLDRYPRQLSGGQQQRVALGRALVRQPQVFLMDEPLSNLDAKLRVYMRAELKRLQRELGITTIYVTHDQAEAMTMADRVAVMNEGKIMQLADPAELYFRPANTFVAGFIGAPAMNFVDASAKVEDDTVVLDTGIYRIRLPKDASEVLIKQGVPSEVIFGIRPEHITVSKQEFPGSFAAEVFVTEPLGSETIIDFKHGDAILKAKYPGHFEASPGEKIYIGFQLQYAHVFDKKTGKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE2</accession>
    <name>A1RZE2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752837.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1174"/>
    <dbReference type="EnsemblBacteria" id="ABL78572">
        <property type="protein sequence ID" value="ABL78572"/>
        <property type="gene ID" value="Tpen_1174"/>
    </dbReference>
    <dbReference type="GeneID" id="4602040"/>
    <dbReference type="KEGG" id="tpe:Tpen_1174"/>
    <dbReference type="eggNOG" id="arCOG00152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031522_0_0_2"/>
    <dbReference type="OMA" id="WTEWQTK"/>
    <dbReference type="OrthoDB" id="8229at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="502" mass="56957" checksum="9EF7B776436D0296" modified="2007-02-06" version="1">MSQKKGLQKTTAILLVVVLLVGLLAGYFIGVSTAPKAPAEEVVPKSQYEQLQKELESVKAQLQQMAAQQGKPVEIVITAWTQGPERESIYRQLNLVEAANRLNQIFKVVGVPATVKVEGDFSTASWTDYRKKVFLALEGGTGPCIFQMEHVWSAVLAENGWIIPLDDYVKKYWNWTYYDIIPGLWSSVTYKGKIWGIPQDTEARPIYFNKLLLKKLGWTDEQINALPEKIRRGEFTLQDMLMVAKEAVDKGVVAPGYGIWHRPTAGPDWPIVYLAFGGKLYDETSGKLVADMKVWKKVFDWFYAASMQKYKVITDKMTSLDWNRDVHPTIVAGKVLFWMGGTWHKGQWVGSFNLSESKFWEMFGFALYPAGEPGLKPVTLSQPQAYFISKTCKYPEIAFLIITLATDPYLNSLHAVKSAHLAIMYRQLSDPVYTKDKFLAMTGYMVEYAQYQPMHPRWGDYNTIIFNTIKGIETGQFDADQALQVFKQNLQSTLGDNVIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH8</accession>
    <name>A1RZH8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752873.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1210"/>
    <dbReference type="EnsemblBacteria" id="ABL78608">
        <property type="protein sequence ID" value="ABL78608"/>
        <property type="gene ID" value="Tpen_1210"/>
    </dbReference>
    <dbReference type="GeneID" id="4600412"/>
    <dbReference type="KEGG" id="tpe:Tpen_1210"/>
    <dbReference type="eggNOG" id="arCOG00186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="LHQHTEG"/>
    <dbReference type="OrthoDB" id="42569at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="259" mass="28900" checksum="9FCD103558D08278" modified="2007-02-06" version="1">MAEPLLEMRGIVKRFGRVEALRGVDFHVGRAEVVGLVGDNGAGKSTLVKIIAGVYQPDAGQMFFEGQPVVFRHPSEARARGIEIVYQHLALIDLLSIDRNIFLGREPTKRIGPIAILDKARMEREAWSILQDIGLRRIRSPSERVAKLSGGERQSVAIGRAMHFKAKLLILDEPTAALSVRETRRVLDHVLEVKKQGVSVIIISHNIYHVYEVSDRIVALDHGRKILDVPREKVTPEEVIDVIRTGAPATPQPEENQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI1</accession>
    <name>A1RZI1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1213"/>
    <dbReference type="EnsemblBacteria" id="ABL78611">
        <property type="protein sequence ID" value="ABL78611"/>
        <property type="gene ID" value="Tpen_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1213"/>
    <dbReference type="eggNOG" id="arCOG03647">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160445_2_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10706" checksum="FA7552955E253255" modified="2007-02-06" version="1">MEEFNRLHGSEGQVRVVEWRGDGFVAEFVGSFCVTCGFYDYFEDFALMVAERGVRVGVVDVEEFEGGARVAYRFLREGEELRFVPERVVLILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK2</accession>
    <name>A1RZK2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752897.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1234"/>
    <dbReference type="EnsemblBacteria" id="ABL78632">
        <property type="protein sequence ID" value="ABL78632"/>
        <property type="gene ID" value="Tpen_1234"/>
    </dbReference>
    <dbReference type="GeneID" id="4601166"/>
    <dbReference type="KEGG" id="tpe:Tpen_1234"/>
    <dbReference type="eggNOG" id="arCOG01773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599103_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="166" mass="17593" checksum="A6E16823E895E2C5" modified="2007-02-06" version="1">MLLKDVLADVASIAARDATPRVALVLPAPPAYRVLPLESLPEGLDAYVVIEPSGSPRGLPEGAAAVYAEALRLPFREGSVGLLLCFACIERADELEGFLKEACRVLGAGGRLVIGGLTPSSRLMIPGSGEGWPPGLFAKVAAKHLSCMDLRVSKDYFVASCRCMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP9</accession>
    <name>A1RZP9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1281"/>
    <dbReference type="EnsemblBacteria" id="ABL78679">
        <property type="protein sequence ID" value="ABL78679"/>
        <property type="gene ID" value="Tpen_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1281"/>
    <dbReference type="HOGENOM" id="CLU_3394571_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="31" mass="3691" checksum="A360D5270485D74A" modified="2007-02-06" version="1">MYLQMLRILEEVGALKHDAKEVYRALKTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ9</accession>
    <name>A1RZQ9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752954.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1291"/>
    <dbReference type="EnsemblBacteria" id="ABL78689">
        <property type="protein sequence ID" value="ABL78689"/>
        <property type="gene ID" value="Tpen_1291"/>
    </dbReference>
    <dbReference type="GeneID" id="4600599"/>
    <dbReference type="KEGG" id="tpe:Tpen_1291"/>
    <dbReference type="eggNOG" id="arCOG02659">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302644_0_0_2"/>
    <dbReference type="OMA" id="VCDVCKL"/>
    <dbReference type="OrthoDB" id="103386at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="222" mass="23725" checksum="46C06FB61F94E4C8" modified="2007-02-06" version="1">MVIRFRLRLRAVSLLTVGWGIPDVLGADIVTARKVKADGTYEYYVPGSTVKGVLRSAASRVAGAYGFTSCGEVDPEKVRKAHEAMGGPCDVCTLFGYPYPSVEGASKVYVSDFSPVGRPAPVIVARTALRDDTQTVREGSLRSVEHLLPGSEFVGEVRVDGAASRLVPLLLLAVAELRTSRVGRGSLVDARVEDGGALDAVVAPEWRGLLEGVRSWLWEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT3</accession>
    <name>A1RZT3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3692 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752978.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1316"/>
    <dbReference type="EnsemblBacteria" id="ABL78713">
        <property type="protein sequence ID" value="ABL78713"/>
        <property type="gene ID" value="Tpen_1316"/>
    </dbReference>
    <dbReference type="GeneID" id="4601996"/>
    <dbReference type="KEGG" id="tpe:Tpen_1316"/>
    <dbReference type="eggNOG" id="arCOG02666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012640_0_0_2"/>
    <dbReference type="OMA" id="TIFDHAT"/>
    <dbReference type="OrthoDB" id="45895at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3692" evidence="1">
        <location>
            <begin position="204"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="978" mass="105966" checksum="4336E0963D665DB2" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT9</accession>
    <name>CAS2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas2</name>
        <name type="ordered locus">Tpen_1322</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752984.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZT9"/>
    <dbReference type="SMR" id="A1RZT9"/>
    <dbReference type="STRING" id="368408.Tpen_1322"/>
    <dbReference type="EnsemblBacteria" id="ABL78719">
        <property type="protein sequence ID" value="ABL78719"/>
        <property type="gene ID" value="Tpen_1322"/>
    </dbReference>
    <dbReference type="GeneID" id="4602002"/>
    <dbReference type="KEGG" id="tpe:Tpen_1322"/>
    <dbReference type="eggNOG" id="arCOG04194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_2_3_2"/>
    <dbReference type="OMA" id="VREDEYQ"/>
    <dbReference type="OrthoDB" id="123741at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000417753" description="CRISPR-associated endoribonuclease Cas2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <sequence length="93" mass="10861" checksum="ECDF36720837F2DD" modified="2007-02-06" version="1">MIVIVAYDISDEDRRGRLRRYLRRLGLARVNRSVYAGPGTATTAELVAERAKEIVEEGDSVFVIVVREDEYQRAHVFDGRDYYIVSERKYEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY7</accession>
    <name>A1RZY7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753032.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1370"/>
    <dbReference type="EnsemblBacteria" id="ABL78767">
        <property type="protein sequence ID" value="ABL78767"/>
        <property type="gene ID" value="Tpen_1370"/>
    </dbReference>
    <dbReference type="GeneID" id="4601195"/>
    <dbReference type="KEGG" id="tpe:Tpen_1370"/>
    <dbReference type="eggNOG" id="arCOG03721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115256_0_0_2"/>
    <dbReference type="OMA" id="IHVWGFH"/>
    <dbReference type="OrthoDB" id="104108at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="19619" checksum="6BF768486A9A8CDF" modified="2007-02-06" version="1">MEKTVVIPRRLVEEVEKRGLSVESLVVDALSKALDLDPEVVAEARLELAAKFMEEADEYLGKGDPVQASEKLYKVAEECIKALAEGFNAPTLEKVRERGRWDTWLLGMAATDLSRILGDERVHLAWSKAYEIHVWGFHEAKYRVEDVAAARPVVKWLLDFAGEALRKARSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S043</accession>
    <name>A1S043_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753088.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1426"/>
    <dbReference type="EnsemblBacteria" id="ABL78823">
        <property type="protein sequence ID" value="ABL78823"/>
        <property type="gene ID" value="Tpen_1426"/>
    </dbReference>
    <dbReference type="GeneID" id="4600722"/>
    <dbReference type="KEGG" id="tpe:Tpen_1426"/>
    <dbReference type="eggNOG" id="arCOG00198">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="SHQVELM"/>
    <dbReference type="OrthoDB" id="68573at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="254" mass="28218" checksum="D2DAF969166701F5" modified="2007-02-06" version="1">MPLLKVLGVTVYYGDFKALGGVSFDVERGEILSIIGPNGSGKTTLLRAIDGILRPRLGAVYLDGREIAGMERREIARIIGYSPQRVDVQSYVTVLDFVLTGRRPYASWDYSESDYRKAVEALRAVNASHLAARRLDQLSGGEFRRVVIARALAGEPDVLLLDEPTNDLDPKHQVEILSAIRRLASGRGVAVVMCLHDLTHAYRYSDKILAMKDGSVYAFGRPEDVMREDLLREVYGVSLKVLPEHRAVIIDHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S063</accession>
    <name>A1S063_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753108.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1446"/>
    <dbReference type="EnsemblBacteria" id="ABL78843">
        <property type="protein sequence ID" value="ABL78843"/>
        <property type="gene ID" value="Tpen_1446"/>
    </dbReference>
    <dbReference type="GeneID" id="4601155"/>
    <dbReference type="KEGG" id="tpe:Tpen_1446"/>
    <dbReference type="eggNOG" id="arCOG01464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649926_0_0_2"/>
    <dbReference type="OMA" id="RWEANIS"/>
    <dbReference type="OrthoDB" id="64671at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="422" mass="44585" checksum="CE1E007234CAD663" modified="2007-02-06" version="1">MKAGKVAAVVVRSVKLFLRDKSTLFWSFAFPLMLLSFYVFLFAPGAGQGRAVSINVAVVPGSEAVAAYAEETAKYLKAPWNASLKLSVNATVWGNLSSAMNALKKGYLDAVVLVEPGSGGTLNVTVYVLRGTPDPSREELVAAYLYSFFYQVAHFEALGELSRFVNATASRVPGLAPAAAEVVERAWRAALNPGVRVVGVVPGEEGAQLRSRVVGWLTLSVVFMSFMFEGVVGGAAAVASEAKRGFLRRLLSTKLTPSEYFAGLAISWLALMAASAVPTCLLGFVAYGGSLAVKILSAEALFLLLLVLVAGLLAFSAGLLIGLFFKSPESASVVANIIVWPTMAAGGFWLPKWMLPDPLRAFAEVNPFSILFSATSEVAVFGRSISGYLLPTVAAVLLSLALFAVAAVLYARLAPRLAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B3</accession>
    <name>A1S0B3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1496"/>
    <dbReference type="EnsemblBacteria" id="ABL78893">
        <property type="protein sequence ID" value="ABL78893"/>
        <property type="gene ID" value="Tpen_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1496"/>
    <dbReference type="eggNOG" id="arCOG03723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2285191_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="11717" checksum="10CFFE6A6AD9ED31" modified="2007-02-06" version="1">MNALFEDSGKALKAARRELDEYRKTGDSMKLRQAAEKGWLAINKAVEEFLKTLGVEAKTYREKRDALKKLGLNTLRDRFMAREKGVTHRLLLRRAVRRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B9</accession>
    <name>A1S0B9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1502"/>
    <dbReference type="EnsemblBacteria" id="ABL78899">
        <property type="protein sequence ID" value="ABL78899"/>
        <property type="gene ID" value="Tpen_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1502"/>
    <dbReference type="eggNOG" id="arCOG02718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149108_2_0_2"/>
    <dbReference type="OMA" id="KVAYLAI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002849">
        <property type="entry name" value="DUF131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01998">
        <property type="entry name" value="DUF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="9504" checksum="E9292B4232F34B21" modified="2007-02-06" version="1">MDAVFQVLIALVAASVVLVLVGFILVALSALRGSPGESKVEAGGVLVVGPIPVIFGSSPEAARKVAYLAIAIMFLSVFLLILLNFLRGVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C2</accession>
    <name>A1S0C2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome bd-type quinol oxidase subunit 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753167.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1505"/>
    <dbReference type="EnsemblBacteria" id="ABL78902">
        <property type="protein sequence ID" value="ABL78902"/>
        <property type="gene ID" value="Tpen_1505"/>
    </dbReference>
    <dbReference type="GeneID" id="4601206"/>
    <dbReference type="KEGG" id="tpe:Tpen_1505"/>
    <dbReference type="eggNOG" id="arCOG02720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690019_0_0_2"/>
    <dbReference type="OMA" id="MFRLVFA"/>
    <dbReference type="OrthoDB" id="66445at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="396" mass="42362" checksum="579783330B28289F" modified="2007-02-06" version="1">MNAPVLFMALVFGVHIVAVNIGIALSTIVPLLVKRSRALGDKGLEGVARSLFKVYAATYGLAGVMGTAFTVFLASFYPEFVGVAGNLTMVPFGISIVSIMLHFFAIVAFWYGWDRFSPKVHEAVGWLLAATAYTIPLGFRAVFAFLNTPAGLVLGEKPSLNVVQALLNPTFPPLYLKSVVGALVAGFLFVAAVLAFKGLRTALTDAERGLYVFSLRYASMLLFAMMFLGAWYAVSLVNVPVKFNNIFAPLGASLPAPTTSNYAWLFLVKMVLVAVQGAALLLVLLPRGKGESLLESPAGYKATITAAVAAALTVLTGEYLNAFSQYPFFVANAPLIADKLPEPYRTILTRALNLENVSPLAQDPALYAATVLGVLVLFAAAGYMIYVVFFKKGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F3</accession>
    <name>A1S0F3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1537"/>
    <dbReference type="EnsemblBacteria" id="ABL78933">
        <property type="protein sequence ID" value="ABL78933"/>
        <property type="gene ID" value="Tpen_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1537"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_2"/>
    <dbReference type="OMA" id="TCGNYGA"/>
    <dbReference type="OrthoDB" id="55286at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="325" mass="34922" checksum="926B82B8EB986BE5" modified="2007-02-06" version="1">MEEGDSSSSKLLALSTPLLKLTSLRKLLNLDGAAVYLKYEGYNPTGTHKDRAALAHVGEAVLNGYDTVTVGTCGNYGVAVAYYARLAGLRAVIFVPKGYSNSRVPEMKRYGARVVEVEGPYEDAVAVSVSSARANGWYDANPGSVNDHVSIEAYSLIAREIVRQLGDAPAVVAVPVGNGTTLVGIYHGFYRLYRAGETTRIPRMVAASTSNANQLVYSWSRGSTEPLPVEVSEVRETPVNEPLVAIRSLNAEEALRAIYASKGAAFGFSDSEMVEMSILLRAFEGVSALPASASALLAVREYLKANEVDGPVVAVITGRWRREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G3</accession>
    <name>A1S0G3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753208.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1547"/>
    <dbReference type="EnsemblBacteria" id="ABL78943">
        <property type="protein sequence ID" value="ABL78943"/>
        <property type="gene ID" value="Tpen_1547"/>
    </dbReference>
    <dbReference type="GeneID" id="4600840"/>
    <dbReference type="KEGG" id="tpe:Tpen_1547"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="MADRMMI"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="39437" checksum="03BF7FFC1B5E9759" modified="2007-02-06" version="1">MVGVRLEHVTKRYGKVVAVDDVSLEVKEGEFFVLLGPSGCGKTTTLRIIAGLEEPDEGRVFFGEEDVTRLPPGKRKISMVFQSYAVWPHMKVYDNIALPLKVQGYPPEEIERRVREAARLVQIEDLLDRYPQQLSGGQRQRVAVARALAVTPRVLLMDEPLSNLDALLRVQARAELKRLQRDTRLTTIYVTHDQVEAMVLADRVAVMNRGRVLQVGPPEEIYSKPSSRFVAHFIGSPPINLFEGTVTPRGVDVGFVVLPVGAGSLEEYSGKRVIVGIRPEDVHLTASPGFIEVEGSVWVTENLGGEYVVLVSVGDVILRARSREKPESERVKVYLDPSKLHFFDKETEARIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J8</accession>
    <name>A1S0J8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753243.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1583"/>
    <dbReference type="EnsemblBacteria" id="ABL78978">
        <property type="protein sequence ID" value="ABL78978"/>
        <property type="gene ID" value="Tpen_1583"/>
    </dbReference>
    <dbReference type="GeneID" id="4600547"/>
    <dbReference type="KEGG" id="tpe:Tpen_1583"/>
    <dbReference type="eggNOG" id="arCOG00465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127125_0_0_2"/>
    <dbReference type="OMA" id="HTNVLRW"/>
    <dbReference type="OrthoDB" id="112525at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="32952" checksum="164054087C45BCCA" modified="2007-02-06" version="1">MSALKIPARGLDLGLTPYPSFTLSLFEEVDGRYVKLAGRSAGCWIAQRGDTVVSTCPRGEVEEYSGLWFLEVKESCRVCDRLYWLLEALEEAYPGLGLSVDTYDPLHIFTAVFLSQSTSYHVNVLSWARRLWRMSGDPLEAAELAPGIGGSYQLRRLPQAVRCVAGGWPRDSAELRLFLLRCRFVGPKTADATLLFARADTASAPVDRHFAAMNRRLGLFEGVRLPEARLCRRYRCGDCPARGDCLRWLAAECFGRLAGWVQTALYVHDRKYCSRGGCGECPLRRECRGVGGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K2</accession>
    <name>A1S0K2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753247.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1587"/>
    <dbReference type="EnsemblBacteria" id="ABL78982">
        <property type="protein sequence ID" value="ABL78982"/>
        <property type="gene ID" value="Tpen_1587"/>
    </dbReference>
    <dbReference type="GeneID" id="4600551"/>
    <dbReference type="KEGG" id="tpe:Tpen_1587"/>
    <dbReference type="HOGENOM" id="CLU_935745_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="33408" checksum="73719F00E16D0848" modified="2007-02-06" version="1">MEPLLVITSPKDESILLEALFEALGVKYTLAEEGDYVTFYLAGENVETLAYKIADKTSLEIGGDLLRIMRIGAGSAIAKYGKVFYAVMRSEEEAEKVASLLKSATGAKVTRRGRRVYGGGEALEWMLEVTLNYRFVRRGVEKEVLALARKTLEPGRRRVRVARRLMLRLYKEFAIRVEGDYIEVPEGRIASYILSGMATDWENLEPVFLEHLGIKHVETAKLRLGHKTAPVDIYVVGEYREVGVARRVSLEDLRDFLDEELVEMIGVGKKGKLYIPDVVLDALLEAGVLERSLRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K5</accession>
    <name>A1S0K5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753250.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1590"/>
    <dbReference type="EnsemblBacteria" id="ABL78985">
        <property type="protein sequence ID" value="ABL78985"/>
        <property type="gene ID" value="Tpen_1590"/>
    </dbReference>
    <dbReference type="GeneID" id="4600554"/>
    <dbReference type="KEGG" id="tpe:Tpen_1590"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="31539" checksum="AAEEDF0E8A4C1268" modified="2007-02-06" version="1">MRRRLAPSRVAVAAALWVFTALWLLPFVALVVMSVKPYKEVVLNGWWTLQGNYSLENYVEVLLNPSFNFVKGLENSFVVASLSTVIPVVFAAMMAYSLTYLSFRYRTLLFVSILVFMSVPQQMVVIPLFSLYVKTGLHDKLAGIILLHSAWGTPWIAFFMRNYFRMLPQSFVEAARIDGASEFTIFWKILLPLSLPAVVAASAIQFTWVWGDFFYAMVFLPSPSNYVVTQRLALLKGEFHIDWGLLSAGAILAMLPPLLVYVAFKKYYVRGFAGWGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L4</accession>
    <name>A1S0L4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753259.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1599"/>
    <dbReference type="EnsemblBacteria" id="ABL78994">
        <property type="protein sequence ID" value="ABL78994"/>
        <property type="gene ID" value="Tpen_1599"/>
    </dbReference>
    <dbReference type="GeneID" id="4601530"/>
    <dbReference type="KEGG" id="tpe:Tpen_1599"/>
    <dbReference type="eggNOG" id="arCOG00137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038661_0_0_2"/>
    <dbReference type="OMA" id="PMVVDMT"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="421" mass="46062" checksum="DFFF99C4B0B2EEA8" modified="2007-02-06" version="1">MERFSYGKIFLLGFGFFGISILWSIYNSYVPIFLKEFGLASWLVGFIMTIDNIFAVVLLPYIGVLSDVTRTRIGRRKPYIILGAPPAALTFALIPLLRGDFYAMLAVIVVMNFSMALFRSPVIAFMPDITPSEKRSQANGIINFMGGVGSLLAFFVGAKLYEMNPSYPFVAAAVTMLLASLLVVLLVDEPEEFKARGGSVRLGELLRESFRKSFSELSANLREAFLGEDKSLLFMLASIFLWFIGYNAIETFFTSYAKWYLGIGEAAGSLILGFVALGFLVFSLPAGFIGARLGRRKTMTLGLALLVVLLGLAFYASTAVKTGAVIYVLGAIFFFGGFAWALVNVNSLPTVVDMTSRERLGAYTGLYYFASQSAAITAPPLAGLFIDVLGYQALFPYSIVFLLASAVTLQFVKRGEARKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L7</accession>
    <name>A1S0L7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein Cas4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1602"/>
    <dbReference type="EnsemblBacteria" id="ABL78997">
        <property type="protein sequence ID" value="ABL78997"/>
        <property type="gene ID" value="Tpen_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1602"/>
    <dbReference type="eggNOG" id="arCOG00790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106570_0_0_2"/>
    <dbReference type="OMA" id="DWECRYC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="226" mass="25557" checksum="D54179B6FD8EEEB1" modified="2007-02-06" version="1">MGRSPPGIIASSPRFYSVSGLDIVKELYGLFREERARHQRERGVVWVTDLVSCSLKPVFSLEYEELALSEFFSPPLVLGTLVHRGLEALLSQVLAAKQYRVEVEPERSLEVSVDDAKYTLKGRADLVVTTPEGARIGVEIKTLRGDAALPLEHHVDQARIYNLLFDLEKSYLVYISPERLAQYEVGDRMGLDEVASRIREPRAPRYTWECRYCPFSVICPSKVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M2</accession>
    <name>A1S0M2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753267.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1607"/>
    <dbReference type="EnsemblBacteria" id="ABL79002">
        <property type="protein sequence ID" value="ABL79002"/>
        <property type="gene ID" value="Tpen_1607"/>
    </dbReference>
    <dbReference type="GeneID" id="4601538"/>
    <dbReference type="KEGG" id="tpe:Tpen_1607"/>
    <dbReference type="eggNOG" id="arCOG02763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184957_0_0_2"/>
    <dbReference type="OMA" id="WIREMSV"/>
    <dbReference type="OrthoDB" id="131570at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="96" mass="10336" checksum="711366B4784A2E06" modified="2007-02-06" version="1">MPLKKATLKVSGIGCGSCVAPSKAHLLRVPGVVAVYVFGSRVEVVYDEERTSLDEVLKSSGVNEYYFVQVLSVESVDDSLGASGRSEKTETLRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N4</accession>
    <name>A1S0N4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753279.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1619"/>
    <dbReference type="EnsemblBacteria" id="ABL79014">
        <property type="protein sequence ID" value="ABL79014"/>
        <property type="gene ID" value="Tpen_1619"/>
    </dbReference>
    <dbReference type="GeneID" id="4601911"/>
    <dbReference type="KEGG" id="tpe:Tpen_1619"/>
    <dbReference type="eggNOG" id="arCOG00153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720842_0_0_2"/>
    <dbReference type="OrthoDB" id="11462at183924"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="450" mass="50794" checksum="DE79ECBD36C32823" modified="2007-02-06" version="1">MSKKPPTKIIALIVLAVIIVAGIGVLLVQQLTPKPKPHLVIWGRATFVPPQMYWIEKKVREWASKNNVDVEITWYAVADIGKKLTAAVEAGNPPDIVINGHPVAIFAEKGLLLPLDDVIEKLNKSDFYEIKLKICSWGGHYYCVPMGFEMTWLHVRWDIVQKAGAQNLFPLKSLDDFYVAAKALHNVEPGVYGVGLPLGLNGYDTWWTFEHFWGGYGGAMLANRSVAGVIMDKEPYRSALKKAFEIERKIWVEKLTPPDSDQWVDASNNNAYIQGKIAMTINPASIYYALMTQNPELAAKTKLFVLPISVDCGDESTFIFKTTKYPDLAKDLVYYLFADKDDYRRGFVEAGALYFLPPFKSQMKVISSDWKKGKYPAFGEDPAVAVEKIKFMETAAFPLGERTTPSETFREGFIWNEMIQRVVVKGEDPDKVIDEYAARLREEVRRVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P4</accession>
    <name>A1S0P4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753289.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1629"/>
    <dbReference type="EnsemblBacteria" id="ABL79024">
        <property type="protein sequence ID" value="ABL79024"/>
        <property type="gene ID" value="Tpen_1629"/>
    </dbReference>
    <dbReference type="GeneID" id="4601032"/>
    <dbReference type="KEGG" id="tpe:Tpen_1629"/>
    <dbReference type="HOGENOM" id="CLU_2127962_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="113" mass="11551" checksum="1E0A19B3E92324CF" modified="2007-02-06" version="1">MRVVSGLAAFIVVVLALAASVASTFILPPAFAPAVFWFVVGGWLVLAALLAGVEESRVVPARALYALYGGLAVTASAAYTVHLLVADARVSLLVLLAGVGATGVAFYVARAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V1</accession>
    <name>A1S0V1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1686"/>
    <dbReference type="EnsemblBacteria" id="ABL79081">
        <property type="protein sequence ID" value="ABL79081"/>
        <property type="gene ID" value="Tpen_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1686"/>
    <dbReference type="eggNOG" id="arCOG01199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175268_0_0_2"/>
    <dbReference type="OMA" id="FREPPHR"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="121" mass="13497" checksum="1CCEC6C9CF54D9E9" modified="2007-02-06" version="1">MKLREEVVKEALEWASRLRGSVTAVLVGSYARGDFNEWSDVDVVLVSGEFKGGPLERLKAIEVPPGYEVIPLTPEEFERLLERGDQLALEAVERGVKLRDDLGLLSRDFAEKARKSRPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V8</accession>
    <name>A1S0V8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1693"/>
    <dbReference type="EnsemblBacteria" id="ABL79088">
        <property type="protein sequence ID" value="ABL79088"/>
        <property type="gene ID" value="Tpen_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1693"/>
    <dbReference type="eggNOG" id="arCOG02109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_3_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="11053" checksum="E9292C0DD327A291" modified="2007-02-06" version="1">MLVEALIALCYHIARNAYGVRPETPVRTFSVLVEKGLMNAWEFEELVKLVRLRNLLIHRYWVVDDRRVYDSVRKDFKAVREFLERVKRELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X0</accession>
    <name>A1S0X0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753365.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1705"/>
    <dbReference type="EnsemblBacteria" id="ABL79100">
        <property type="protein sequence ID" value="ABL79100"/>
        <property type="gene ID" value="Tpen_1705"/>
    </dbReference>
    <dbReference type="GeneID" id="4601667"/>
    <dbReference type="KEGG" id="tpe:Tpen_1705"/>
    <dbReference type="eggNOG" id="arCOG01424">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_2_1_2"/>
    <dbReference type="OMA" id="RIYLIEV"/>
    <dbReference type="OrthoDB" id="92770at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="271" mass="31293" checksum="05DD0A26357ECF81" modified="2007-02-06" version="1">MAIPSIDWSRLEEVVERAVRRARADELRDLAEAVKVLAEYMKTGFESTLRAIEDHSKMIEELTKEVRNNSRILEEHSKVLGEHSRRIEELAGEIRNHSRVLEEHSKRLEELTREVRNHSRILEEHSERLKELTKSVGELKAAVGSIGRRWGRDLEKLVYELYKDALLGLGVKDVGKIEKYTYVDIDGKYYRRGARIELDIYMHDTSVYFIEVKSLLEVDDVYWFNEKCGIVSKIIGRTPTRRIIVAVNAAKEAIEAARELGIDVVYGSIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S108</accession>
    <name>A1S108_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753403.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1743"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79138">
        <property type="protein sequence ID" value="ABL79138"/>
        <property type="gene ID" value="Tpen_1743"/>
    </dbReference>
    <dbReference type="GeneID" id="4601768"/>
    <dbReference type="KEGG" id="tpe:Tpen_1743"/>
    <dbReference type="eggNOG" id="arCOG01417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053640_0_0_2"/>
    <dbReference type="OMA" id="LHENIDY"/>
    <dbReference type="OrthoDB" id="96027at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="236"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="420" mass="47173" checksum="C8B7D040FDEE1892" modified="2007-02-06" version="1">MHSSKPQLAVVANPSEHGSGGELRALRSVKEYAKHFHVYLFTPLRAVGSTSLRSLARLKSLGVALSGCITYPRIGKLEPEFKLFFPQLTRLTTTKLPFFDGIVVLHENIDYLYAGYLLGKASGAPAMVLLQNPPLFGSKKRLSEILKAVYLWEKLTSASTLEEAYATVRLARLQVRRPIEEARIRMLLNKYSLVVGVSRATVLEMGEPWFSKAFYLDPGVNLNEEEVHLLSRIRKSVKEKENCILYKGGLTPVKGILDVLLAYRLIRKERGDLKLVITGKLDSKTHRKLLVALKKLNLKDYVVLTGFISREQLFELNAKARLLLHPSHMDSFPYTVLESLHAGTPVVGYDIPALKIYYGGLPGVRLVREGDVEALATEAIDMLERSPKEVNPPSLKSWNEIIEEELSLVKKKLLGEHRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S125</accession>
    <name>A1S125_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753420.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1760"/>
    <dbReference type="EnsemblBacteria" id="ABL79155">
        <property type="protein sequence ID" value="ABL79155"/>
        <property type="gene ID" value="Tpen_1760"/>
    </dbReference>
    <dbReference type="GeneID" id="4601958"/>
    <dbReference type="KEGG" id="tpe:Tpen_1760"/>
    <dbReference type="eggNOG" id="arCOG00953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058377_0_0_2"/>
    <dbReference type="OMA" id="CIYCELG"/>
    <dbReference type="OrthoDB" id="73459at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040084">
        <property type="entry name" value="GTPase_Obg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01083">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="323" mass="35765" checksum="40D0A52E5A1D2D40" modified="2007-02-06" version="1">MDSALAFGPVPSRRLGRSLGVNNIPAKVCSYSCVYCQVGRTTVLTVERRAFYEPEKVYEAVKAKLGEAASRGERVDFVTFVPDGEPTLDANLGREISLLKGLGKPVAVLTNASLLWREDVREDLAGADFVSVKVDAVEEGLWRRVNRPSRELSLEKVLEGVSVFAEEFKGTLVSETMLVGGVEYGEELQRLADFLGGLRRLAKAYVAVPVRPPAEKWVKPAGEEVVNAAYQLLSERLGPGRVELLTGYEGSDFAPTGNVREDLLAITAVHPMRRDAVEEFLKRAGAEWGVVEELVRENLLVEIEYEGKLYYIRRISRLAGREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S126</accession>
    <name>A1S126_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1761"/>
    <dbReference type="EnsemblBacteria" id="ABL79156">
        <property type="protein sequence ID" value="ABL79156"/>
        <property type="gene ID" value="Tpen_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1761"/>
    <dbReference type="eggNOG" id="arCOG04356">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038336_0_0_2"/>
    <dbReference type="OMA" id="VMIPDFR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="DUF790"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="PTHR39640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019435">
        <property type="entry name" value="UCP019435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="468" mass="52934" checksum="FF13F34E1EEC29C3" modified="2007-02-06" version="1">MLPSNLLVARARRGRIEPLLLEPSGLPVALASEVLELFERGVGKGRRELEEGLADLEELALELGLDLRVVRAMFTLAARHARFEPPKAPVDPVKARMEVFEEACREFGVAVTEEERSTVLRRVAERLGCSVEDLESVLGGYLEEVLAEPPALKAEDLVRMLNLSMVQTLLFKASQLEVVFRSDGATAKKLLRAVKRLGLLYVAEQLGEGVRLTVDGPASLLRQTRRYGTRLAKLVPLVMLAERWRIRARVPARGRDLFFELGDEKSGLFPRVEEEPEPLFDSEVEREFYRSISSLARGWRVEREPEPLVAGNKVLIPDFSVSNGERKVYIEILGFWTKDYLERKMQKLRELRGVNIVVAVNEELACSSVKDLPHDVVVFKGRLRGADVYPVLKRYLGEPPEEPREEVEYRLEGLPDLSGRTLSEAIRELRKLGVPESEAVKVLEKLGYGVDWTTLDPDKLVLKKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S132</accession>
    <name>A1S132_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753427.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1767"/>
    <dbReference type="EnsemblBacteria" id="ABL79162">
        <property type="protein sequence ID" value="ABL79162"/>
        <property type="gene ID" value="Tpen_1767"/>
    </dbReference>
    <dbReference type="GeneID" id="4601944"/>
    <dbReference type="KEGG" id="tpe:Tpen_1767"/>
    <dbReference type="eggNOG" id="arCOG02216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565779_0_0_2"/>
    <dbReference type="OMA" id="FSIIVIR"/>
    <dbReference type="OrthoDB" id="85253at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="491" mass="51796" checksum="BAD116203BD064B7" modified="2007-02-06" version="1">MKSTGLLFYAERVYSTLTGLLFVLIVTRSLSPEEFGAWSVISTLLSYATVATVVNYWVTRLRSRGVVEVTVSGLALSLLFALASSGAYLVLLPYLSGEFGVARSALLVSTLYIPVLYVNGALYSSLYAVSPARAAVSEFLFETGKTVAAVLFALSGGVSLVSALIAVLAGHILQGAFLAVSTRRDLVRRPSAALAKRVLSLSTFNFAAQPSTLLSSLDVPLISAVRGNLSVAYYTVVNTFSNLVGYSGVLSKGLYPSLLSVDDSSAHRERIEESLRLVLLVGIPAAAGVAALAPNLLYLLRPDYVAAANVLRVAAVTSIVASVNGVFSDALQGVERADLEGKGLREVARSRIFKVFALGYVKLAVGLPGVVAAVYLSGDPLAVALLGKASWLAAELVVFAILLWWIRGHARLGAVARSLLAYSAASVPAVLVALAVNPYRIREAFLALLLAGATYFGSLYVLDPWFRSQASRVAALLARRSPPSTTSARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S134</accession>
    <name>A1S134_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753429.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1769"/>
    <dbReference type="EnsemblBacteria" id="ABL79164">
        <property type="protein sequence ID" value="ABL79164"/>
        <property type="gene ID" value="Tpen_1769"/>
    </dbReference>
    <dbReference type="GeneID" id="4601946"/>
    <dbReference type="KEGG" id="tpe:Tpen_1769"/>
    <dbReference type="eggNOG" id="arCOG06085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2839565_0_0_2"/>
    <dbReference type="OMA" id="KDRMEDR"/>
    <dbReference type="OrthoDB" id="132174at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="66" mass="7603" checksum="BBD23DDB5B2CC10B" modified="2007-02-06" version="1">MAKSIRLRESTYRALVRLKERMGARSFDEVVAKLAYKELGIPEDLFGADRGKVEPFSPEDRMEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S192</accession>
    <name>A1S192_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753487.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1827"/>
    <dbReference type="EnsemblBacteria" id="ABL79222">
        <property type="protein sequence ID" value="ABL79222"/>
        <property type="gene ID" value="Tpen_1827"/>
    </dbReference>
    <dbReference type="GeneID" id="4602064"/>
    <dbReference type="KEGG" id="tpe:Tpen_1827"/>
    <dbReference type="eggNOG" id="arCOG07492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109679_0_0_2"/>
    <dbReference type="OMA" id="TERFFLM"/>
    <dbReference type="OrthoDB" id="125610at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="219" mass="24142" checksum="03A541F6CAACEBDB" modified="2007-02-06" version="1">MPEWDVVQLFQQVVIEIAALAPKVGLATLILFVTLLVVKLVNKSIRWLVSVARLDEYLRKSLPEGTRIPLSTLLVLVADAGILTSSAALVVRVFVPEYSQAYREALSYISRIGSVAVLSLFSFVVIDALVKSMRMERKTERFFVMMSLLVVTLLIVDLASLSNEIKLALALGIAIGIGFLVGAFAAWAFFGEYLDALVRVRTGQPGLEREKNLPEDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A1</accession>
    <name>A1S1A1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753496.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1836"/>
    <dbReference type="EnsemblBacteria" id="ABL79231">
        <property type="protein sequence ID" value="ABL79231"/>
        <property type="gene ID" value="Tpen_1836"/>
    </dbReference>
    <dbReference type="GeneID" id="4602073"/>
    <dbReference type="KEGG" id="tpe:Tpen_1836"/>
    <dbReference type="HOGENOM" id="CLU_827996_0_0_2"/>
    <dbReference type="OrthoDB" id="135185at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="335" mass="37474" checksum="A960A829A0F659D9" modified="2007-02-06" version="1">MNIADYVDYMRGYVERAPASRRGDLARAMFSRVVAFLGQNPGFVLRSVRDPYLKAYLLSEVPAYLPMLWEESLREVERMLPALSATKKVFVYSRLSETAKELNKSYSEYLGAALALLDRGSWRARSRMVISLVNLGRVEEAIELSRYLPASRRALALAEASALNPMQEAVWREAVESVKKVRDWSRRVVALSRLLKAGAFQDGYGSLLVAEGVARMFSELRSEADVYLALLVARNLAEAGFLSYAERLWFASRQFLRKHPLVDLDVEELAVEVALYLEGLDAAVEAASSSTEYSWYLLPALFNYAVSSGFFSQSWAARIRNGSGARVLPAGRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A6</accession>
    <name>A1S1A6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751361.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1841"/>
    <dbReference type="EnsemblBacteria" id="ABL79236">
        <property type="protein sequence ID" value="ABL79236"/>
        <property type="gene ID" value="Tpen_1841"/>
    </dbReference>
    <dbReference type="GeneID" id="4600312"/>
    <dbReference type="KEGG" id="tpe:Tpen_1841"/>
    <dbReference type="HOGENOM" id="CLU_2327397_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="98" mass="10318" checksum="BA92D836F2F1B140" modified="2007-02-06" version="1">MRPDEAVRTAKAIRLLFALLNTLLLVLLIPSAFRMALGGIELPMMLGSIAGVALSRRYPQVSGIILLINVLALVVSAGVPAIIKPLAPPVSPVNLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D9</accession>
    <name>A1S1D9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Competence/damage-inducible protein cinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751394.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79269">
        <property type="protein sequence ID" value="ABL79269"/>
        <property type="gene ID" value="Tpen_1874"/>
    </dbReference>
    <dbReference type="GeneID" id="4600345"/>
    <dbReference type="KEGG" id="tpe:Tpen_1874"/>
    <dbReference type="HOGENOM" id="CLU_2839560_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="65" mass="7842" checksum="56A532CBF6C9D29F" modified="2007-02-06" version="1">MRGDVQIRIIADKERISEEEYRLIVSAVEELLIRMGLQVRRSRPYTARKMRRGVRVYIEARKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW50</accession>
    <name>A1RW50_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0020"/>
    <dbReference type="EnsemblBacteria" id="ABL77430">
        <property type="protein sequence ID" value="ABL77430"/>
        <property type="gene ID" value="Tpen_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0020"/>
    <dbReference type="eggNOG" id="arCOG05661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166571_0_0_2"/>
    <dbReference type="OMA" id="WALTIIR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8085" checksum="F862507E3176193E" modified="2007-02-06" version="1">MLLGVAGMLLIIAAWIASFKDVPSPRLSSLYAAGSFLLAVHSVLIGDPVFLVLNSLATALALLNLYRWYRGRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW64</accession>
    <name>A1RW64_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751709.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0034"/>
    <dbReference type="EnsemblBacteria" id="ABL77444">
        <property type="protein sequence ID" value="ABL77444"/>
        <property type="gene ID" value="Tpen_0034"/>
    </dbReference>
    <dbReference type="GeneID" id="4601675"/>
    <dbReference type="KEGG" id="tpe:Tpen_0034"/>
    <dbReference type="HOGENOM" id="CLU_1850739_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="138" mass="14695" checksum="2910D949F3C36F31" modified="2007-02-06" version="1">METGKNVEEVVLRVSEELERFGLKNIVSEDSRTLIVLLDVAEGKEVPVLTTFSEESFSIVVPVNASVSELEERLSGLGGKVHTMDLGENLAGIVVEAEGLPGAEELAGKLREVGRLLESLLSSEKVGVCCSGEVLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW77</accession>
    <name>A1RW77_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0047"/>
    <dbReference type="EnsemblBacteria" id="ABL77457">
        <property type="protein sequence ID" value="ABL77457"/>
        <property type="gene ID" value="Tpen_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0047"/>
    <dbReference type="eggNOG" id="arCOG04128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_0_2"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="217" mass="23515" checksum="5A25C8CB10E02B63" modified="2007-02-06" version="1">MVSLGSVKVLGNPVLQEILGKLRSRDTPRREFRELLFKAGVFEAYEIAEELPTEECSVETPLGRRAPCVRVTGKLAIVAVLRAALPMAMGMLEVFPDAALGFVAAKRLEADAPPRDWRLEVSVPYVSMPPDAENLVIVDPMLATGSTLASVIERLKGGGYSYGRLYVATVISTEQGIRRVLSVEPEARIYTLSVDPELNDKAFIVPGLGDAGDRAFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC3</accession>
    <name>AMPPA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP phosphorylase</fullName>
            <shortName evidence="1">AMPpase</shortName>
            <ecNumber evidence="1">2.4.2.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside monophosphate phosphorylase</fullName>
            <shortName evidence="1">NMP phosphorylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0093</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate</text>
            <dbReference type="Rhea" id="RHEA:36975"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine</text>
            <dbReference type="Rhea" id="RHEA:36987"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:36991"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABL77503" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.4.2.57" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77503.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWC3"/>
    <dbReference type="SMR" id="A1RWC3"/>
    <dbReference type="STRING" id="368408.Tpen_0093"/>
    <dbReference type="PRIDE" id="A1RWC3"/>
    <dbReference type="EnsemblBacteria" id="ABL77503">
        <property type="protein sequence ID" value="ABL77503"/>
        <property type="gene ID" value="Tpen_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0093"/>
    <dbReference type="eggNOG" id="arCOG02013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_6_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046125">
        <property type="term" value="P:pyrimidine deoxyribonucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02132">
        <property type="entry name" value="AMP_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017713">
        <property type="entry name" value="AMP_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013466">
        <property type="entry name" value="Thymidine/AMP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03327">
        <property type="entry name" value="AMP_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02645">
        <property type="entry name" value="ARCH_P_rylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000314732" description="AMP phosphorylase">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="511" mass="55569" checksum="C655AF7EA9714244" modified="2008-01-15" version="2">MKLKTRILPFESAHYTVVLDQSVAKKLDVRPSDRVLVRFNGKTVVAIANIAKEFSHEHVGVYVNIAKALGISDGDEVEVEATSPPASLQAIRKKLQGLSLESDEIYQVVKDIVDGKLSELELAAFVTAVHFQGMTPSEIYSFTLSMVETGQRLRLKRKPILDKHSLGGVPGDKTSLLVVPIIASLGFTIPKTSSRAITSAAGTADRMEVLAPVNLSIDEIERIVEKTNACLVWGGALNLAPADDIIIRVEYPLGIDPFYIPSILAKKLAVGSTHVVLDVPTGRGTKVKTLEEAKRISQSFFEIARMFGMNLQAVATYAEEPIGHAIGPALEAREALIALRELRPGDLVDKAASLAGTLLEMVGVENGYETAMEALRTGKAEKKLREIIEAQGGDPDVTPEEIPLGDKTYTLYSEEDGFVYYIDNSLLANIGKIAGAPIDKGAGVYIHVKLGEKVRKGDPLLTVYSSSSAKLQAVERILEDSKPVLVGRTAGRRMLLERIQYQPPRQLVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD7</accession>
    <name>A1RWD7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0107"/>
    <dbReference type="EnsemblBacteria" id="ABL77517">
        <property type="protein sequence ID" value="ABL77517"/>
        <property type="gene ID" value="Tpen_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0107"/>
    <dbReference type="eggNOG" id="arCOG01759">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_3_0_2"/>
    <dbReference type="OMA" id="MINGTYT"/>
    <dbReference type="OrthoDB" id="81987at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="155" mass="17120" checksum="52A384C290A00364" modified="2007-02-06" version="1">MSEEEVKYYKADIAGLYPIKVPQPEGEQTAYLLLLETAEWKDKALPIIIGENEGLAIQSALMGVKYERPMTHDLIVSILDALGVEVEKVSIDALLNNSVYTATIYLKRTVNGKVEEINVDSRPSDGIAIAVRTGSPIYVAAHLEKHARRLEELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE3</accession>
    <name>A1RWE3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751788.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0113"/>
    <dbReference type="EnsemblBacteria" id="ABL77523">
        <property type="protein sequence ID" value="ABL77523"/>
        <property type="gene ID" value="Tpen_0113"/>
    </dbReference>
    <dbReference type="GeneID" id="4601055"/>
    <dbReference type="KEGG" id="tpe:Tpen_0113"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_2"/>
    <dbReference type="OMA" id="WYGDILA"/>
    <dbReference type="OrthoDB" id="78828at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="254" mass="28761" checksum="D0601CB1F0167C6D" modified="2007-02-06" version="1">MPQNFGVVLCGGEGKRLRPLTYYFQKAMIPVGTQQKPLLEYIVRLLAYHGLRRIILLVGYKGQQIVNYFNSGERYGVNISYVWDDPNYGGNGGALFNAYVRGFFEGSDNILVYYGDILSDINLSDFLSFHERGQYAATLALSPNYRVAVGVAELDGDRVVKLVEKPPLGKPVTIGVVAIRTKALEYLRELVEEKREVDIMGDFIRVLLERGLKVGGYLTNSFWFDLGTTEAYEKLDPVEVDRRFSFLFQSRESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE5</accession>
    <name>A1RWE5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751790.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0115"/>
    <dbReference type="EnsemblBacteria" id="ABL77525">
        <property type="protein sequence ID" value="ABL77525"/>
        <property type="gene ID" value="Tpen_0115"/>
    </dbReference>
    <dbReference type="GeneID" id="4602164"/>
    <dbReference type="KEGG" id="tpe:Tpen_0115"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032971_0_0_2"/>
    <dbReference type="OMA" id="SASHIYP"/>
    <dbReference type="OrthoDB" id="114071at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="13517" checksum="25F80A9399135129" modified="2007-02-06" version="1">MAQNSKEVRLKREKIRVNTVIKLYTLILLAEGEKHGYELMRTLEQMIEAPIGPSQIYPFLRNLENAGLVTSREAGSRDKKVYSLTPQGYEFLKEILEKSLNVIQTAIRVLGREKVCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH8</accession>
    <name>A1RWH8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751823.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0148"/>
    <dbReference type="EnsemblBacteria" id="ABL77558">
        <property type="protein sequence ID" value="ABL77558"/>
        <property type="gene ID" value="Tpen_0148"/>
    </dbReference>
    <dbReference type="GeneID" id="4600640"/>
    <dbReference type="KEGG" id="tpe:Tpen_0148"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OMA" id="AIQLPWF"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="128"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="354" mass="39855" checksum="C0E3C0FADB81EFD3" modified="2007-02-06" version="1">MVSKKLVKHIALRAIVIYLTVVVAVYLTIIVANMGGKIDEFVLGDLYTSIYEQINRDPRYRSLPGPEKDKLVKQMFELEVKRLGYDRPFLERSFIYLKNALTLDLGRALFMTSDSGSRLVKNIILERLPNTVMLFTTVTVINFFIHLFLGLYLSRHYGSFFDKLVVALSPTSTLPGWFYGIFLILIFYTWLHVLPPGGMVDVPPPPDPISYALSVLKHMILPMASWIISGFFLGVYGTRTFFLIFSTEDYVEAAKAKGLPPRLIETRYILRPSLPPIVTNFALSLIGSWGGAIITETVFEWPGLGLVTWRAIQSFDTPVLVGITVIYAYLLAATVLILDFVYALIDPRIKAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK3</accession>
    <name>A1RWK3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ModE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0173"/>
    <dbReference type="EnsemblBacteria" id="ABL77583">
        <property type="protein sequence ID" value="ABL77583"/>
        <property type="gene ID" value="Tpen_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0173"/>
    <dbReference type="eggNOG" id="arCOG00223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125440_2_1_2"/>
    <dbReference type="OMA" id="SYKRAWD"/>
    <dbReference type="OrthoDB" id="108915at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="12116" checksum="337C20E0FD805380" modified="2007-02-06" version="1">MGDIEVRYKVWLVKDGKPILGKGGAELLKAIEEKGSLHAAAEALGYSYSFAWSYLKKLEERAGVTLIERRRGGQRHGGMVLTEEARKLLKLYLEAERVVGEALSQIQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM1</accession>
    <name>A1RWM1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751866.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0191"/>
    <dbReference type="TCDB" id="1.A.16.2.5">
        <property type="family name" value="the formate-nitrite transporter (fnt) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77601">
        <property type="protein sequence ID" value="ABL77601"/>
        <property type="gene ID" value="Tpen_0191"/>
    </dbReference>
    <dbReference type="GeneID" id="4600624"/>
    <dbReference type="KEGG" id="tpe:Tpen_0191"/>
    <dbReference type="eggNOG" id="arCOG03454">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_1_1_2"/>
    <dbReference type="OMA" id="WMAYGAK"/>
    <dbReference type="OrthoDB" id="61925at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="382" mass="41538" checksum="90D319E7BD42EEE5" modified="2007-02-06" version="1">MATEEKFTPYAGVDETVDAAASAAVVKAFQPPGRLFLMGIMAGIFIGIGFWLAVTVSSAFWTTKVTGFDAATHKLVTEPFNVAWPLNPSAMMKFLLGAVFPVGLIAVCIGGAELWTGCANVIPLGYMQKKLKLKALIYNWVTAYGGNWVGSVFLAFLATYGSTLLLASPFRDELISVVWAKVNLSPWEAFWRGVGCNFLVNLAIWLWLRSKKGDFMGQAFLIWFPIFTFVTIGFEHSIANMFLIPAAIFASPLALKQYIITYYDFFFNNLLPVTYGNLVGGFVFIALVYWYVGMVKGSKYGEATPTDALKYAAEILLLAGIVHHVLEVAVPGAIAVAVEKALGLSAGINLTNAGMALIPAVITGIYYALLPFIVYKALKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM9</accession>
    <name>A1RWM9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD-related deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751874.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0199"/>
    <dbReference type="EnsemblBacteria" id="ABL77609">
        <property type="protein sequence ID" value="ABL77609"/>
        <property type="gene ID" value="Tpen_0199"/>
    </dbReference>
    <dbReference type="GeneID" id="4600808"/>
    <dbReference type="KEGG" id="tpe:Tpen_0199"/>
    <dbReference type="eggNOG" id="arCOG00891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_5_2_2"/>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="OrthoDB" id="48998at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="242" mass="27250" checksum="7602C38FF008934A" modified="2007-02-06" version="1">MTVVDVHIHLAEFTREKIEEFVSRGYILVGVAEDYETSLKVLELRDSYPENVKACVGIHPWSLRNLEDYTRELELVSQLLPDADCVGEVGLDKKFVPETFHQQLAVFRELAGRAVERGVPLNVHSAGAWREVLEVLGELGAKKVVLHWWTGPLNLLLELSRRGYFVSVNAALKVQEKSRVIAREAPLDALLTESDGPYEYRGLSLSPSLIPEALQIIAQIKGLAVDELERAIYRNFTRVFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP1</accession>
    <name>A1RWP1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ordered locus">Tpen_0211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751886.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0211"/>
    <dbReference type="EnsemblBacteria" id="ABL77621">
        <property type="protein sequence ID" value="ABL77621"/>
        <property type="gene ID" value="Tpen_0211"/>
    </dbReference>
    <dbReference type="GeneID" id="4601804"/>
    <dbReference type="KEGG" id="tpe:Tpen_0211"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="OMA" id="KPTTNYI"/>
    <dbReference type="OrthoDB" id="111461at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="91" mass="9767" checksum="DA6839CEBE83B89F" modified="2007-02-06" version="1">MSEVGTVFVGNKPVSSYVLAAVTQFTSGSKRVVLKARGRAISRAVDAAELVRRFLGGKVDYGNIKIGSEKVGEPGKERTVSTIEIELVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT6</accession>
    <name>A1RWT6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751931.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0256"/>
    <dbReference type="EnsemblBacteria" id="ABL77666">
        <property type="protein sequence ID" value="ABL77666"/>
        <property type="gene ID" value="Tpen_0256"/>
    </dbReference>
    <dbReference type="GeneID" id="4601848"/>
    <dbReference type="KEGG" id="tpe:Tpen_0256"/>
    <dbReference type="eggNOG" id="arCOG14758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1017886_0_0_2"/>
    <dbReference type="OrthoDB" id="101873at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="275" mass="31165" checksum="C4622B5A4EC708A9" modified="2007-02-06" version="1">MPWIGIGKKCLENEQEVAKYLEDSGVQVLKKFELEIEVDGEWIPFLVFEVLGFVEGLSEDLSRNFQCPTLESGPHLVLGEVSAKLWDEAVKVVFPDGGSRIIPVFTFDAFLDIRVPTKKVKGLKGQLILAGRVFELPLSKDDLLFIAKLDKKYLEKIEKAVAVYGLDKILSKEAQAELAGKPSKKSLSYEVDYESGMALVMLENKIQTIGIPRLAVLLAEEEMYRDIREIYGKISEELKEKMKEALLDYYEFRKLSGRSLKDLEELLKELGVEVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU6</accession>
    <name>RFCL_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Replication factor C large subunit</fullName>
            <shortName evidence="1">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rfcL</name>
        <name type="ordered locus">Tpen_0266</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751941.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWU6"/>
    <dbReference type="SMR" id="A1RWU6"/>
    <dbReference type="STRING" id="368408.Tpen_0266"/>
    <dbReference type="EnsemblBacteria" id="ABL77676">
        <property type="protein sequence ID" value="ABL77676"/>
        <property type="gene ID" value="Tpen_0266"/>
    </dbReference>
    <dbReference type="GeneID" id="4601684"/>
    <dbReference type="KEGG" id="tpe:Tpen_0266"/>
    <dbReference type="eggNOG" id="arCOG00470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027255_1_1_2"/>
    <dbReference type="OMA" id="GGWTRYG"/>
    <dbReference type="OrthoDB" id="24257at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000292186" description="Replication factor C large subunit">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <sequence length="413" mass="46515" checksum="2F14CBE19ECBA93A" modified="2007-02-06" version="1">MSAVKVQLVPWTEKYRPARIADVVGNEEAKKKYVAWINSWVKGKPSKKAALLYGPPGSGKTSIVHATAKEFSWELIELNASDVRTREALQQRLLGALNTRSVLGYSGKIILLDEVDGISTKEDAGGLQAIVELIEKSNWPIVLTANDPWDPKLRPLRDLCELIEFKKIGKRDIMKVLENICSKEGVECSREVLSAIADNAKGDLRAAINDLQSLAMGKKTISLADLQILGDRAEQETIFDIVRSVLTAKYPEQALAVTRLPSLDYEMLMQWLSENIVYQYEPSLQAIADAYDALSWADIMLTRMKREQQWALLSYALELMTAGVASARERPPFKFVKYSFPEKLRILARSKEKREKFVRAVRGAAAKIHVSTSKFRTDVLPYLRVIYEHDKKRALEILRNLGVPEDALELATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW8</accession>
    <name>A1RWW8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0288"/>
    <dbReference type="EnsemblBacteria" id="ABL77698">
        <property type="protein sequence ID" value="ABL77698"/>
        <property type="gene ID" value="Tpen_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0288"/>
    <dbReference type="eggNOG" id="arCOG00405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_2"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="11"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="497" mass="57813" checksum="0C84B5FC31070A95" modified="2007-02-06" version="1">MEEKYRDITLDELTDLCIRRGIVFPSGRIYGGLAGFYDYGPVGVELERNILNDWWKWFVETRDDIYGIDGAIITHPRTWEASGHVESFIDYIVTCTSCGAEYRADHLLEEVGVKIPEYSLETIKSLIENNNVRCPACGGKLSEPRKFNLMFDTQVGPRKSMTAYLRPETAQLIFTNFKNVVFTMGATLPFGIAQIGKAFRNEISPRNFLFRLREFTQMEIEYFVNPEKLNECPYFKEVEELRVNFLSAEEQERGVSEAKSIKLGEAVETGVIKNAWHAYWIGESLRWLWSLGLRPERLRVREHVKTELAHYAVQTFDIEYFFPYMGWKEIEGIANRSDYDLKRHQEYSGEALHIVDNGKTVIPYVIEPSFGLERILLAVLTDSYVREERRTYLRLKPRIAPFKCAVFPLVKRDGLDVKAREIYNQLKKHFRCYYDEDGSIGRRYAKADEIGVPFSITIDGQTLRDDTVTIRFRDTKEQIRERVENLKARLSELIATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW9</accession>
    <name>A1RWW9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arcadin_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751964.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0289"/>
    <dbReference type="EnsemblBacteria" id="ABL77699">
        <property type="protein sequence ID" value="ABL77699"/>
        <property type="gene ID" value="Tpen_0289"/>
    </dbReference>
    <dbReference type="GeneID" id="4601298"/>
    <dbReference type="KEGG" id="tpe:Tpen_0289"/>
    <dbReference type="eggNOG" id="arCOG05582">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160450_0_0_2"/>
    <dbReference type="OMA" id="MIAIQIV"/>
    <dbReference type="OrthoDB" id="114758at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040827">
        <property type="entry name" value="Arcadin_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18653">
        <property type="entry name" value="Arcadin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arcadin_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="12692" checksum="7EC6D8D4C5BA71AB" modified="2007-02-06" version="1">MSVSFRAKVTNISLMDAPFGEKLVKLELTEERELPGPVIVQKDESEIGREIAPIIAQVMRMMPGLAPNTVRIPRVTLVLTEDEWERFPVKPSIGDFFVIEVSGENVKIRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX00</accession>
    <name>A1RX00_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl35ae</name>
        <name evidence="5" type="ordered locus">Tpen_0321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751995.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0321"/>
    <dbReference type="EnsemblBacteria" id="ABL77730">
        <property type="protein sequence ID" value="ABL77730"/>
        <property type="gene ID" value="Tpen_0321"/>
    </dbReference>
    <dbReference type="GeneID" id="4600972"/>
    <dbReference type="KEGG" id="tpe:Tpen_0321"/>
    <dbReference type="eggNOG" id="arCOG04304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_3_1_2"/>
    <dbReference type="OMA" id="SKENQHN"/>
    <dbReference type="OrthoDB" id="108945at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="L35A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_L35A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_L35Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="9791" checksum="6C10F9FBEC4CAD22" modified="2007-02-06" version="1">MEGWIVSFRRGMNKYYPRQVILSLDGVTYKDAVKVIGRKVLWVHPETGEKFVGKIVRMHGRRGHVLAYFKRHLPGQAVGTKVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX10</accession>
    <name>A1RX10_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752005.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0331"/>
    <dbReference type="EnsemblBacteria" id="ABL77740">
        <property type="protein sequence ID" value="ABL77740"/>
        <property type="gene ID" value="Tpen_0331"/>
    </dbReference>
    <dbReference type="GeneID" id="4601698"/>
    <dbReference type="KEGG" id="tpe:Tpen_0331"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312314_0_0_2"/>
    <dbReference type="OMA" id="IAFETIM"/>
    <dbReference type="OrthoDB" id="7292at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119494" checksum="60E9AA3F45D25811" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX21</accession>
    <name>VATA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">Tpen_0342</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752016.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX21"/>
    <dbReference type="SMR" id="A1RX21"/>
    <dbReference type="STRING" id="368408.Tpen_0342"/>
    <dbReference type="PRIDE" id="A1RX21"/>
    <dbReference type="EnsemblBacteria" id="ABL77751">
        <property type="protein sequence ID" value="ABL77751"/>
        <property type="gene ID" value="Tpen_0342"/>
    </dbReference>
    <dbReference type="GeneID" id="4601452"/>
    <dbReference type="KEGG" id="tpe:Tpen_0342"/>
    <dbReference type="eggNOG" id="arCOG00868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="6736at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000322485" description="V-type ATP synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <sequence length="601" mass="66895" checksum="B1BEC48E692C68BA" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX43</accession>
    <name>A1RX43_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase, subunit L</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752038.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0364"/>
    <dbReference type="EnsemblBacteria" id="ABL77773">
        <property type="protein sequence ID" value="ABL77773"/>
        <property type="gene ID" value="Tpen_0364"/>
    </dbReference>
    <dbReference type="GeneID" id="4601493"/>
    <dbReference type="KEGG" id="tpe:Tpen_0364"/>
    <dbReference type="eggNOG" id="arCOG04111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_5_1_2"/>
    <dbReference type="OMA" id="NVRFRIK"/>
    <dbReference type="OrthoDB" id="129622at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="3">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="11065" checksum="3D66C207BA80316A" modified="2007-02-06" version="1">MQSTGGVAREDTVVEVVRYATNVLELRIRGEGHTLLNLLVDELNRIPDVEATYRVDHPLLNVAHLLVRTKGSKQPLEAIREAVESLRAKLKVVAESAAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX55</accession>
    <name>A1RX55_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA biogenesis protein Nop56/Nop58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0376"/>
    <dbReference type="EnsemblBacteria" id="ABL77785">
        <property type="protein sequence ID" value="ABL77785"/>
        <property type="gene ID" value="Tpen_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0376"/>
    <dbReference type="eggNOG" id="arCOG01923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_1_0_2"/>
    <dbReference type="OMA" id="REWYSLH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="267"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="412" mass="46488" checksum="1B19337A5295BF58" modified="2007-02-06" version="1">MQMNVYLHFTPLGPVLVNEEGQILASDMITQDKDPEKIARFMYELETGNVPERVLGFLASSLSKEYTLAVEDEEVARKISQSLKEVKVTVQPGSKVHRALREQQQAIVEKAFGISYSDYYRLVREATILLARWKVKEVAEKRDLYVAQAVNALDDVNKTINLFASRVREWYGLHFPELNDIVEDHEDYFKIVSKLGSRSNISLEKLKELGFKDDLAQKIVKAASNSMGAELTEFDLNAIRLLSDAGLQLYSIRRNLEKYIDEAMYDVAPNIRGLVGPTLGARLISLAGGLEKLARLPASTIQVLGAEKALFRALRFGARPPKHGVIFQHPYIHKSPKWQRGKIARALAGKLAIAARIDAFTGEYKADELREDLEKRIEEIKTLYAKPPAKQAKKEPAQKKFRGHGKRKGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX70</accession>
    <name>A1RX70_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752065.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0391"/>
    <dbReference type="EnsemblBacteria" id="ABL77800">
        <property type="protein sequence ID" value="ABL77800"/>
        <property type="gene ID" value="Tpen_0391"/>
    </dbReference>
    <dbReference type="GeneID" id="4600526"/>
    <dbReference type="KEGG" id="tpe:Tpen_0391"/>
    <dbReference type="eggNOG" id="arCOG00352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_0_0_2"/>
    <dbReference type="OMA" id="DPSEYCG"/>
    <dbReference type="OrthoDB" id="66209at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="169"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="334" mass="37811" checksum="9584D8DF81AE5902" modified="2007-02-06" version="1">MDIQYLKRRMVYAPQSVEELFELAVRSCKRKSSAKGVDKVETRRIRALECVKLAAGVLSSRLRDVALTSPFLEDLHPFYRSLVTIDLDVDLYKSCTSRLYSASKIIKKIGLEQRVRIRRAKTYEEIVSAEKAFFGRALSVLRELEECLPMLRKFQLTFAKLPEIDLDIPTVIIAGAPNVGKSSLLKSLTRAKPEVKPYPFTTKELIVGHIEHPLGKIQLVDTPGLLDRPLEEKNPIELKAVVALKHITGLVLFVVDPTETCGFTLDFQYAVYRGVKSFISSEAWIVVNKLDIAQTEHMDNFRRVFGAVDYVAVSAEKKIGVDNLKEKIIEKFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF5</accession>
    <name>A1RXF5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="3" type="ordered locus">Tpen_0476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752150.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0476"/>
    <dbReference type="EnsemblBacteria" id="ABL77885">
        <property type="protein sequence ID" value="ABL77885"/>
        <property type="gene ID" value="Tpen_0476"/>
    </dbReference>
    <dbReference type="GeneID" id="4602035"/>
    <dbReference type="KEGG" id="tpe:Tpen_0476"/>
    <dbReference type="eggNOG" id="arCOG00638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_2_1_2"/>
    <dbReference type="OMA" id="DFGWRNV"/>
    <dbReference type="OrthoDB" id="104636at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="312" mass="33377" checksum="3DFDB5065E9F4D03" modified="2007-02-06" version="1">MPELREDVVVDKVTSLLGLRKDDAAVLSLEETSLVVNVDSFESGIHLYPFLPPRIAGRRAAVGSISDVLVKGAKPLGILVSLRVPSTADLGFLEEFYRGLLEAGTRFGARILGGDTDVSSTCYLRVDVVAIGVSRGKVLHRWGAKPGELVAITGRVGISSVLYALSSGGALSCNPGNSLVEEYGWGQLPEPATWLGIKELLTSAIDNSDGLALSLYYLAESSGVGIVVEELPVHAVAKECLPRERLVDAVLYASGEDYNFIFTFPEEAEEEVRKTGATIIGRVTEGEGVFLSDGRRVERKGWIGGPGYSPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ2</accession>
    <name>A1RXJ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinyl-CoA synthetase (ADP-forming) beta subunit</fullName>
            <ecNumber evidence="8">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.5" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752187.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0516"/>
    <dbReference type="EnsemblBacteria" id="ABL77922">
        <property type="protein sequence ID" value="ABL77922"/>
        <property type="gene ID" value="Tpen_0516"/>
    </dbReference>
    <dbReference type="GeneID" id="4601354"/>
    <dbReference type="KEGG" id="tpe:Tpen_0516"/>
    <dbReference type="eggNOG" id="arCOG01337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_2"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="72275at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="7">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="6">
        <location>
            <begin position="254"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="372" mass="40795" checksum="B7E6D540FEAA909B" modified="2007-02-06" version="1">MIPYEFEVKDIFEKFQVPVEKSCLLTHEALKDSLGCIKGLRTPLIVKAQVRGWGRGKAGLVKSAENPEEALKVAQEFFLREFNGEKIRYVLVSERKRILREMYLSFMVSSNPPGFLLLASKHGGVDVEELSKTPGGLLKIFIDPFEGLRDYMVRTVAGYLGVPQEHIEKILRSLWQIFREYNFTLLEVNPLALTEDGVLALDRKGVIDDDASRKSSLTGIFARYFSELDELSLSAFQKGFSVVKLDGDTAVVGNGAGLTMATLDAVLEAGARPGLFLDLGGGADAERVREALLLVLKQQNISKILLNILGGITRCDEVARGVVQALSSAKPSSVKVAVRLSGFMEDEGRRILREAGLSAFDSLEEAVASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ5</accession>
    <name>A1RXJ5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ordered locus">Tpen_0519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752190.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0519"/>
    <dbReference type="EnsemblBacteria" id="ABL77925">
        <property type="protein sequence ID" value="ABL77925"/>
        <property type="gene ID" value="Tpen_0519"/>
    </dbReference>
    <dbReference type="GeneID" id="4601357"/>
    <dbReference type="KEGG" id="tpe:Tpen_0519"/>
    <dbReference type="eggNOG" id="arCOG01742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="OrthoDB" id="32191at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="410" mass="46561" checksum="B124EEC318781366" modified="2007-02-06" version="1">MQESIERYKLEKLVEELKKKEGRGTELVSLYIPAGRPISDVLNTLYYEYSTASNIKDRVTRHHVLDALATIINRLKLFRETPPNGLIVFAGYVAGDVPGREKMEVHLIEPPQKLNVWLYRCDSRFYTEILEEMIRVKEVYGLIVIERDEAAIAILRGKSLEVVDELTAGVPGKHRSGGQSARRFERIIEQLVHEFYKRVGEHANKIFLPLKDELRGIIIGGPGFSKKEFAEGDYLHYELRQKILGLFDVGYGGVSGLYELLEKSKDLIKDVQFMKEREAVNQFLYHLARDTGLAVYGEAEVREALQLNAVEKLLLSEDLEKIRVRAKCTSCKHEFEATLHSESEVAQLKCPKCGGEVEIIENRSVVEELAELAEKTGAEVVLVSTQSAEGKEFFKTFGGIGAILRYRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK2</accession>
    <name>A1RXK2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0526"/>
    <dbReference type="EnsemblBacteria" id="ABL77932">
        <property type="protein sequence ID" value="ABL77932"/>
        <property type="gene ID" value="Tpen_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0526"/>
    <dbReference type="eggNOG" id="arCOG03247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126383_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="166" mass="18052" checksum="5968721D29E00337" modified="2007-02-06" version="1">MLYSAARLNRGGRSLPEVLALARARKASRLVVIYRGRGGNPGRMVFFDLSGDAPRVFPYLIRLRGVVFSPGSAASRRPAREVPVVSLGSETELAEELSVMLDVTYLGAMGEEAVAKYPGRLMVVEKVDRPSLAYVIKFYEGGSAIGPKLLIESLVRIRSRSLEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ6</accession>
    <name>A1RXQ6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="9" type="ordered locus">Tpen_0581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752251.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0581"/>
    <dbReference type="EnsemblBacteria" id="ABL77986">
        <property type="protein sequence ID" value="ABL77986"/>
        <property type="gene ID" value="Tpen_0581"/>
    </dbReference>
    <dbReference type="GeneID" id="4600696"/>
    <dbReference type="KEGG" id="tpe:Tpen_0581"/>
    <dbReference type="eggNOG" id="arCOG01575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_2"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="57069at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="7">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="8">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="245" mass="27008" checksum="D7F362AA5A6CCAF4" modified="2007-02-06" version="1">MKRGAPERLIDENGRRVDGRLPDEMRPLRVEAGVLKNADGSAYVELGNNKVLAAVYGPREPMPRHEALPDRAILKCRYSMLPFSVAERKSPQPSRREIELSKVIREALAPAVFLNEYPRTSIEVYIHILEADGGTRTASIIAGSVALADAGIAMRDLVAAIAVGKIGNVLVLDINGIEDQYGDGDMPIAMMPQRGEITLLQADGVFTPQEIEEALRLAQKAFQKIYAEQVRALKTKYESVKEVEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ7</accession>
    <name>RRP4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rrp4</name>
        <name type="ordered locus">Tpen_0582</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXQ7"/>
    <dbReference type="SMR" id="A1RXQ7"/>
    <dbReference type="STRING" id="368408.Tpen_0582"/>
    <dbReference type="EnsemblBacteria" id="ABL77987">
        <property type="protein sequence ID" value="ABL77987"/>
        <property type="gene ID" value="Tpen_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0582"/>
    <dbReference type="eggNOG" id="arCOG00678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071769_0_0_2"/>
    <dbReference type="OMA" id="GPYIPEV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0271">Exosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000416236" description="Exosome complex component Rrp4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <sequence length="237" mass="26222" checksum="40C2FB519B73D662" modified="2007-02-06" version="1">MRGGAVTIHVKDRQIVAPGEFVGEQGRFRVEGQVFRVGRKYYSKVLGVVTVDEENRVVKVIPLKGKYFPVEGHIVVGKVVDIGFTSWEVDINSPYVAVLPVSEVTSRPVTISRNELSRILDVGDLILAKIVSFDLSKDPVLTIKESRLGKIPRGTLVEIPPQKVPRVIGRRGSMVSMIEDLLGVKLIVGQNGRIVVVGDDPQRVEIAVLAVRKIEAEAHTTGLTDRIKQFIEERLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ9</accession>
    <name>A1RXQ9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="6" type="ordered locus">Tpen_0584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752254.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0584"/>
    <dbReference type="MEROPS" id="T01.970"/>
    <dbReference type="EnsemblBacteria" id="ABL77989">
        <property type="protein sequence ID" value="ABL77989"/>
        <property type="gene ID" value="Tpen_0584"/>
    </dbReference>
    <dbReference type="GeneID" id="4600699"/>
    <dbReference type="KEGG" id="tpe:Tpen_0584"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="OrthoDB" id="57654at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="238" mass="26346" checksum="A23550301947D80C" modified="2007-02-06" version="1">MFPAAPMAGYDRAITIFSPEGRLYQVEYAFEAVKRGMTALGVKAVDGVVLAVEKRSASPLVEGTEKIKKIDSHVGVAFAGLFGDARVLIDQARIYAQSHRLVYGEPIPIELLVKRICDIKQVYTQHGGVRPFGVAFLFAGVDRKGPHLIQTDPGGTYLRCKARAIGAGAQKALDLFVKEYHDDIKIEEATLLALRGLKEAMEDGFTPENIELARIDVYTKEFKIFSTEELAKLFEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT2</accession>
    <name>A1RXT2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Tpen_0607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0607"/>
    <dbReference type="EnsemblBacteria" id="ABL78012">
        <property type="protein sequence ID" value="ABL78012"/>
        <property type="gene ID" value="Tpen_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0607"/>
    <dbReference type="eggNOG" id="arCOG00860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="OMA" id="HHNASEH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="259" mass="27470" checksum="8E885A76F4A92993" modified="2007-02-06" version="1">MNPAMLTVIKLGGSVITDKSKPYTVRSSNLKTASAALAKLYGEGYDIVLVHGGGSFGHPTAAKYRLHEGGLSPEKVRGFSETRYWMTKLNTLVVEHLLRLNVPAVSLQTSAIAVNSGGKLSRISLDVLREMLARRLVPVLYGDAVIDLSRGFSILSGDTLAARIAVELGAKSLVYVMGAGGVYSKPPGSPDARLLREIAENDVLTVGGTHGVDVTGGLREKLAEAFYAAKNGVRVCIGGVNFIEKMVKGEEAPYTVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT6</accession>
    <name>A1RXT6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0612"/>
    <dbReference type="EnsemblBacteria" id="ABL78016">
        <property type="protein sequence ID" value="ABL78016"/>
        <property type="gene ID" value="Tpen_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0612"/>
    <dbReference type="eggNOG" id="arCOG00016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_3_0_2"/>
    <dbReference type="OMA" id="CCIGHIT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="315" mass="34609" checksum="A3F7AC50242D37CA" modified="2007-02-06" version="1">MWGLKVDVYLIGHLTVDIVVEGGNMRRSLGGTVTFGSLAAIRHNATPHVVSKVGRDFPDEYLMYLGRNNVDLSYVRLSRYLPTTKFKLVYREGGERVLYLLSRCEDILSSDVPLDKLKGNIAVIGALIGEVPPSVVQEISEHASLVVSDLQGYVRRQSEDRSIVLASTPEAKLLISLSDVVHAEVAEAKAVFGDLPPAELAKRIVEGGAAVALVTLGAGGAYVATKQRVLFVPSFPTRVVDRTGAGDVFTTVFAIEYHRLGDYREAAAYATAAVSFLIEKPGPDGLRSRWEVKRRAEKILNEIREYPLDEDRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU1</accession>
    <name>A1RXU1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="8" type="ordered locus">Tpen_0617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752286.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0617"/>
    <dbReference type="EnsemblBacteria" id="ABL78021">
        <property type="protein sequence ID" value="ABL78021"/>
        <property type="gene ID" value="Tpen_0617"/>
    </dbReference>
    <dbReference type="GeneID" id="4601323"/>
    <dbReference type="KEGG" id="tpe:Tpen_0617"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="17629at2157"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="201"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="432" mass="47974" checksum="66927E92B48B1516" modified="2007-02-06" version="1">MEYRVKDISLAPKGRLMVEWAERHMAVLRSIKESFSERQPLKGVKIAACMHVTKETAVLMLTLKAAGAEIALAASNPLSTQDPVAAYLASEGVSVFAWKGMTEREYFESIARAASIEPDITMDDGGDLTVMLHKLSIGEAKGLDYEVAKEIVPPDAYKRVVGGTEETTTGVIRLRALEREGKLLYPVIAVNDSMTKYMFDNRFGTGQSTLDGILRATNILLAGKNVVVAGYGWVGRGIAWRARGMGARVIVVEADPIKALEAYYEGFYVTDMREASKIGDVFITATGNRDVVREEHFLEMRDGAILANAGHFNVEISVEDLERISTSKRRINENVEEYTLRNGKKLYLLSEGRLVNLAAAEGHPSEVMDLSFGNQALAVHLLWKKKGKLKPKVYRLPAQLDRRIALIKLKSLGVRIERLTPKQVEYLRSWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW4</accession>
    <name>A1RXW4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2 subunit alpha (AeIF-2a)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752309.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0642"/>
    <dbReference type="EnsemblBacteria" id="ABL78044">
        <property type="protein sequence ID" value="ABL78044"/>
        <property type="gene ID" value="Tpen_0642"/>
    </dbReference>
    <dbReference type="GeneID" id="4601439"/>
    <dbReference type="KEGG" id="tpe:Tpen_0642"/>
    <dbReference type="eggNOG" id="arCOG04107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="84684at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="265" mass="30130" checksum="411E588134A1982D" modified="2007-02-06" version="1">MVRRREDVPSLNELVVGTVIDIQDHGAFVSLDEFGGLKAYIPLGEVSHSWFKNIRDVLKVGRKYVLKVIRVDRNKKLVDVSLRRVSEKERREKIIEWKRAQRAEKILEMAASKLNKTLDDAYREAGWKLEDHYGEIFRGLEEASARGEEALLEAGVSKQWAKVLAELARQGIKPKKVKLSALINLQCLSKGIEGVKSTLTEWENVVSIPRDASVRVYTLGSPRYKLDIEAQSYKEGEKILAEIISVMEQAAKKNGCSFSYKRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW5</accession>
    <name>A1RXW5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="4" type="ordered locus">Tpen_0643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0643"/>
    <dbReference type="EnsemblBacteria" id="ABL78045">
        <property type="protein sequence ID" value="ABL78045"/>
        <property type="gene ID" value="Tpen_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0643"/>
    <dbReference type="eggNOG" id="arCOG04108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199465_0_0_2"/>
    <dbReference type="OMA" id="DCENEQV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="PTHR11594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="65" mass="7115" checksum="D02179B451C76C24" modified="2007-02-06" version="1">MGHERKALIPQPRSKFLKIRCPDCGNILVTYSHASTKVKCPKCGKILVEPTGGKALIIAEILEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY26</accession>
    <name>A1RY26_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752371.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0704"/>
    <dbReference type="EnsemblBacteria" id="ABL78106">
        <property type="protein sequence ID" value="ABL78106"/>
        <property type="gene ID" value="Tpen_0704"/>
    </dbReference>
    <dbReference type="GeneID" id="4601378"/>
    <dbReference type="KEGG" id="tpe:Tpen_0704"/>
    <dbReference type="HOGENOM" id="CLU_1665589_0_0_2"/>
    <dbReference type="OrthoDB" id="141110at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="17970" checksum="C3C8C81166590DCF" modified="2007-02-06" version="1">MKAFAFELKAVDPKPLDLAVKPYLLTVCSGKATVLSPVRRRQFLEEDLVGFDEEIGFLIGIVYNDFFHGEGNVEVFEYDVSSSCEMVAKIYEVRDSGFLYYRARVYKRSEGVEGWTVIFSDHFSKPGRPKHKLEELSAIIGVRLEELAEALKEEHAAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY30</accession>
    <name>HFLX_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hflX</name>
        <name type="ordered locus">Tpen_0708</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752375.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY30"/>
    <dbReference type="SMR" id="A1RY30"/>
    <dbReference type="STRING" id="368408.Tpen_0708"/>
    <dbReference type="EnsemblBacteria" id="ABL78110">
        <property type="protein sequence ID" value="ABL78110"/>
        <property type="gene ID" value="Tpen_0708"/>
    </dbReference>
    <dbReference type="GeneID" id="4601589"/>
    <dbReference type="KEGG" id="tpe:Tpen_0708"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="33372at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000412668" description="GTPase HflX">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Hflx-type G" evidence="1">
        <location>
            <begin position="194"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <sequence length="424" mass="47211" checksum="9C82C7436C6093D6" modified="2007-02-06" version="1">MSVDGRQAVIVVARLSGKGDLALLDELRKLVEAAGYAVAGELLQKSRYEDPKYNIGRGKVLELKRLVEEKKPLKVVFLNDLKPNQAYNLSKETGVEVIDRYELILEIFAKRAGSRESKLQIELAKLKRELSFAKEYINLAKRGELHGFLGGGKYAVDAYYAYVSMRISKIEEELRKIRKMKEERIARRVEAGLYTVALTGYTGAGKTTLFNVLTGENGYIDGKPFATLSTLSRRTYFHGFPVLVTDTIGFIDDLPDALVDAFYTTLRETLAADVILLVLDVSDTPAEIRRKLTASMEVLLNLGVPPTRILLVGNKIDKVSSAELEERERLLEDSGLRYTLISAARRIGIHELTQAVVEMLPEKVSATLALTREALAEDLRELLDRCRVREVVQGSDGKLLVVVEGRRDIVARLQARAGMGLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY37</accession>
    <name>A1RY37_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0715"/>
    <dbReference type="EnsemblBacteria" id="ABL78117">
        <property type="protein sequence ID" value="ABL78117"/>
        <property type="gene ID" value="Tpen_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0715"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OMA" id="QIDCACA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="3"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="399" mass="44573" checksum="FF56F6A1ED57A674" modified="2007-02-06" version="1">MTVQVGIVGKPNTGKSTFFAASTLIDVKRAPYPFTTIEPNVGVGYVRVQCVCKELGVKDNPRNSICIDGWRFIPVELIDVAGLVPGAWEGRGLGNMFLDHLRRAPVLIHVVDASGGTDEEGRPVPPGTHDPLQDVFFLEKEFAMWMLQVVSRDWEKISKLIDLQKKYDELYAKFTGLGVDVGVVDKALEELSLKTKKATSWTREDLMHLVEYVMRKAKPMVIAANKADLDVSEDNIKRMAKELGDRYTVVPTSAEAELALRKAEKAGLIRYIPGDPDFEIVGKPTREQEKALEYIREKVLKRWGSTGVQKAIDTAVFEKLGMIVVFPVENEKKFSDSHGNVLPDALLVSKEATARDLAYQIHTDIGRRFSFAIDARTGQRVSASEKLRHRMVIKIVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY52</accession>
    <name>A1RY52_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752397.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78132">
        <property type="protein sequence ID" value="ABL78132"/>
        <property type="gene ID" value="Tpen_0730"/>
    </dbReference>
    <dbReference type="GeneID" id="4600850"/>
    <dbReference type="KEGG" id="tpe:Tpen_0730"/>
    <dbReference type="eggNOG" id="arCOG03733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607245_0_0_2"/>
    <dbReference type="OMA" id="IMKHTWE"/>
    <dbReference type="OrthoDB" id="142776at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="165" mass="18549" checksum="51E6B108D25213EC" modified="2007-02-06" version="1">MSGLAPVIERLKGLYDKADDLWGEYVESVKAAVREWELSKLDLLSELSELKAKLESDLKALEELKLKVELGLVDKEKAEKKIGELESEVEKLRGEVESLWVALEEFTLRSLTHSKRAGLPLGLTEEDVASKQETLKKAFERGVIGETAYNAIRSTLEQLLELLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY58</accession>
    <name>A1RY58_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Like-Sm ribonucleoprotein, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0736"/>
    <dbReference type="EnsemblBacteria" id="ABL78138">
        <property type="protein sequence ID" value="ABL78138"/>
        <property type="gene ID" value="Tpen_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0736"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_0_2"/>
    <dbReference type="OMA" id="QSDGTMN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="PTHR11021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="100" mass="11305" checksum="CE55A3B46EB00157" modified="2007-02-06" version="1">MQPIEHLRNQSGKGVFVKLKDGSEYMGKLRMTDAAMNLVLDDAKELTETNKVVAQLGTVFIRGSNLLFVSLEPEKVTFFEPQQEQRGQAREEDMNDSNSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY76</accession>
    <name>SYT_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">Tpen_0754</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752421.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY76"/>
    <dbReference type="SMR" id="A1RY76"/>
    <dbReference type="STRING" id="368408.Tpen_0754"/>
    <dbReference type="EnsemblBacteria" id="ABL78156">
        <property type="protein sequence ID" value="ABL78156"/>
        <property type="gene ID" value="Tpen_0754"/>
    </dbReference>
    <dbReference type="GeneID" id="4601075"/>
    <dbReference type="KEGG" id="tpe:Tpen_0754"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029833_0_0_2"/>
    <dbReference type="OMA" id="DAHIFML"/>
    <dbReference type="OrthoDB" id="11656at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000020545" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Editing domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="192"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic">
        <location>
            <begin position="193"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <sequence length="608" mass="69661" checksum="2415F8F5E090C2BD" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY79</accession>
    <name>A1RY79_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Tpen_0757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752424.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0757"/>
    <dbReference type="EnsemblBacteria" id="ABL78159">
        <property type="protein sequence ID" value="ABL78159"/>
        <property type="gene ID" value="Tpen_0757"/>
    </dbReference>
    <dbReference type="GeneID" id="4601078"/>
    <dbReference type="KEGG" id="tpe:Tpen_0757"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_2"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="57885at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="12">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="342" mass="37745" checksum="748B137CDB073DA9" modified="2007-02-06" version="1">MKIRVGINGFGRIGRNFLRAALKNEKFFDKFEIVAINDLGSPKMLAYLLKYDSVFGRLPNKVEVKDNKLVVDGMEMLVLNEASPEKLPWKDLGVDVALEATGRFTDREKAALHLKAGAKKVVVTAPSKGADVTIVMGVNHHMYDPKKHEVISNASCTTNCLAPVVYVLLKNFGLEWGFMTTVHAYTNDQRVLDLIHPEDFRRTRAAALNIIPTTTGAARALHLVIPEVKGKLDGMAMRVPVADGSVVDLVAQIGREITKEELDAAFKEAAETYLKGILEYVDEPIVSSDIVGNPHSSIYDAQASMVLGGKSNKVKVVAWYDNEWGFSNRLVDLLLYMSEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY96</accession>
    <name>A1RY96_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752441.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0774"/>
    <dbReference type="EnsemblBacteria" id="ABL78176">
        <property type="protein sequence ID" value="ABL78176"/>
        <property type="gene ID" value="Tpen_0774"/>
    </dbReference>
    <dbReference type="GeneID" id="4601096"/>
    <dbReference type="KEGG" id="tpe:Tpen_0774"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_1_2"/>
    <dbReference type="OMA" id="MPVRIYE"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="253" mass="28405" checksum="B6A3DA67153A4539" modified="2007-02-06" version="1">MSDQEWSFFLKEEPPKDSVFIVGLPDVGLVGPISTSHLVKQWELREIGYLDSASLPPVILFHEYSPLFPIRFYGGYKKNDYVVVLHSDIAIPPELVPSMASFLTESLFRKSARRVVLLGGIAVQNRLNIETPKTYAASIDAESLRYAQEKGIELLKEGFIGGAYAQFLKEGYKRKLSVIALLAECFLNYPDPGASASALQALAKILGHDVDVKQLLEQEEEIRVKLRELMKRTMESMRGAGKEYEYTVPALYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB0</accession>
    <name>A1RYB0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752455.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0788"/>
    <dbReference type="EnsemblBacteria" id="ABL78190">
        <property type="protein sequence ID" value="ABL78190"/>
        <property type="gene ID" value="Tpen_0788"/>
    </dbReference>
    <dbReference type="GeneID" id="4601136"/>
    <dbReference type="KEGG" id="tpe:Tpen_0788"/>
    <dbReference type="eggNOG" id="arCOG00373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544716_0_0_2"/>
    <dbReference type="OMA" id="GNDEYNQ"/>
    <dbReference type="OrthoDB" id="105859at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="529" mass="61380" checksum="CC33C99473B2EEDC" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC5</accession>
    <name>A1RYC5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78205">
        <property type="protein sequence ID" value="ABL78205"/>
        <property type="gene ID" value="Tpen_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0804"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090896_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="267" mass="30211" checksum="8C17316CD0B316F3" modified="2007-02-06" version="1">MATPSHARNLSKHHVDIGVTAGVLGSTRTSIEWKVLIYGYADELGWASMLIGEAKRAEFRQLIDACRVLQGDPVALYTAFLGDGLRTFFLRIRVLFFRIGNEVLYLPAESAVVNARLAVELAPEYTKFVSLVTRCAKIKHFLYVGYGLPQKRGMRDGQRKNPFYAEIAGARLHLVYISTRNHVYARIAVEAVPLGWVEEARAQGWDVRVVNMGSEEYYQVTHASLMEHARYDVALRATLIAFAKYKAEQYPKAWELVNRLEKLGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD0</accession>
    <name>A1RYD0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752475.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0809"/>
    <dbReference type="EnsemblBacteria" id="ABL78210">
        <property type="protein sequence ID" value="ABL78210"/>
        <property type="gene ID" value="Tpen_0809"/>
    </dbReference>
    <dbReference type="GeneID" id="4602140"/>
    <dbReference type="KEGG" id="tpe:Tpen_0809"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_0_2"/>
    <dbReference type="OMA" id="HYYDIQH"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="283" mass="31835" checksum="51BABF176A818C96" modified="2007-02-06" version="1">MRVRDVLRGKIPENLLPLVPSSFDVVGSREAAVAIVELPDELLPYKEAIAEAILQVHKNVKAVYRKLGGRVGEYRVRELELIGGEPITEVVHKEHGYRLKLDVTKVYFSPREATERQRIARQVKPGETVMVMFAGVGPYAIAIAKAQPRVEKVIAIELNPAAYAYMVENVKLNKVEGLVVPVLGDVREKAREWYGSCDRVVMPLPRGAYMFLDEAVRCLKSGGGWIHFYYWDREDDLFAKAFSLVKEAAEKHGFRAELRGARIVSPYSPRTYKVAIDVLLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD3</accession>
    <name>A1RYD3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-type H+-transporting ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752478.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0812"/>
    <dbReference type="EnsemblBacteria" id="ABL78213">
        <property type="protein sequence ID" value="ABL78213"/>
        <property type="gene ID" value="Tpen_0812"/>
    </dbReference>
    <dbReference type="GeneID" id="4602143"/>
    <dbReference type="KEGG" id="tpe:Tpen_0812"/>
    <dbReference type="HOGENOM" id="CLU_168733_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="116" mass="13360" checksum="8C1A6703E58F966F" modified="2007-02-06" version="1">MGEKRGVNPARLAEELDIGVILQEQRKAEQRVAEAKKRAEEILERARAQAREILSKAQNVELDDKAKELIESEQRRVGELLKQLEEKYSSELEELRRALEENEEAIKRLVLEAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD6</accession>
    <name>A1RYD6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0815"/>
    <dbReference type="EnsemblBacteria" id="ABL78216">
        <property type="protein sequence ID" value="ABL78216"/>
        <property type="gene ID" value="Tpen_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0815"/>
    <dbReference type="eggNOG" id="arCOG04124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_3_2"/>
    <dbReference type="OMA" id="ACPYDKT"/>
    <dbReference type="OrthoDB" id="127137at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="123" mass="14272" checksum="30896D2805AE0F4F" modified="2007-02-06" version="1">MDLLACPYDKHFPLELYVIETRTYKDRQVTFRRKPACELYCAFRGKNVSELDGKDPGCDECIKVEVATGVLYCPECGRWWPIKDEIPVILPDDMRNKEEDLKFLESVKDKVPEKVLKGKPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE1</accession>
    <name>A1RYE1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752486.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0820"/>
    <dbReference type="EnsemblBacteria" id="ABL78221">
        <property type="protein sequence ID" value="ABL78221"/>
        <property type="gene ID" value="Tpen_0820"/>
    </dbReference>
    <dbReference type="GeneID" id="4601991"/>
    <dbReference type="KEGG" id="tpe:Tpen_0820"/>
    <dbReference type="eggNOG" id="arCOG01900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_8_1_2"/>
    <dbReference type="OMA" id="MNLDLYH"/>
    <dbReference type="OrthoDB" id="90639at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="30600" checksum="95FD1FBCDD73D715" modified="2007-02-06" version="1">MPARLFKLSMVIANPKARFDAVARLDPSTAVKALSELGYDGVEISVLEPVEVGELALLAREHSLEVPAVGTGLNYIHYGLSLTSPDAGVRERARRRIEEIVFEASRREIKGVIVGLIRGRGDEWGDVEGARRLLVEELRGLARKAGEQGVSLFLEPLNRYESRLVNTVEEGLRVLEEVGEDNLLLLLDTFHMNIEERVIEDSIRLASGRIGHFHVADSNRLAPGMGHLDFVRILHALRDAGYSGFVSAEIQVKPDFEAAARITMNTLSTAISVVSQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG5</accession>
    <name>A1RYG5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752510.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0844"/>
    <dbReference type="EnsemblBacteria" id="ABL78245">
        <property type="protein sequence ID" value="ABL78245"/>
        <property type="gene ID" value="Tpen_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="4600778"/>
    <dbReference type="KEGG" id="tpe:Tpen_0844"/>
    <dbReference type="HOGENOM" id="CLU_1444743_0_0_2"/>
    <dbReference type="OrthoDB" id="140363at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="196" mass="21352" checksum="BD2BDECC29950790" modified="2007-02-06" version="1">MSRRVLLGLSLLLLATLLAVNAFSAGTLRGESPRVEVQGYPRLLVYAPPSLNITQGSVGVLVCTVSNVGDAPAENTYLSVVAAGCAYLSTDGENWKKNLTFFLGTFPGHSLRRFTVFVACREAERGRIIVTAVADNHDPVITTVDVAVQPREAPRQSSVEWTPVLAILALSTPIAYYMVSRRRSKEKKKKKSFNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN2</accession>
    <name>A1RYN2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752577.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0911"/>
    <dbReference type="EnsemblBacteria" id="ABL78312">
        <property type="protein sequence ID" value="ABL78312"/>
        <property type="gene ID" value="Tpen_0911"/>
    </dbReference>
    <dbReference type="GeneID" id="4602124"/>
    <dbReference type="KEGG" id="tpe:Tpen_0911"/>
    <dbReference type="eggNOG" id="arCOG00162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_2"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="OrthoDB" id="97465at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="263" mass="28672" checksum="F6EED19F6748E7BE" modified="2007-02-06" version="1">MKLKRVLQLYTALLLAFLYAPLAFIVVQSFNAAKYPGAWRGFTLEWYFELARDSEILQAAANGLAVAVLSATLSTVLGGVAAYYFSKRGSSGAADSFFYAPIVIPEIVESVSLLMLYYSAGVELGFWTVLVGHTAYNVSYAYVALKPQFKVTSRSVEDAAYTLGARPFDVFVRVYFPMALPGIVASLLITFAMSFDDFVKTAFTTGPGFKTLPLVIWARAARGRATTELNALASLMILVSLAASYVYSRQVLLAKKERFTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP8</accession>
    <name>A1RYP8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752593.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0927"/>
    <dbReference type="EnsemblBacteria" id="ABL78328">
        <property type="protein sequence ID" value="ABL78328"/>
        <property type="gene ID" value="Tpen_0927"/>
    </dbReference>
    <dbReference type="GeneID" id="4600750"/>
    <dbReference type="KEGG" id="tpe:Tpen_0927"/>
    <dbReference type="eggNOG" id="arCOG04260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_2"/>
    <dbReference type="OMA" id="GHMKMHL"/>
    <dbReference type="OrthoDB" id="27586at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="428" mass="46395" checksum="235641F8A91723FB" modified="2007-02-06" version="1">MSSEQRTSRIPEFYKKPIEERLKIVAEFAGLTEEEVALLKNFGNLDRKIADSMIENVIGAMSYPFAVAVNFLINGKDYIVPMVIEEASVVAAASNAARVMRRDGGIKSVATQPIMIGQIQVLGVKDPWYKRMVLLEHKEEILQKANEVDPVLVKFGGGARDLEARVVESPRGPMLIVHLLVDVRDAMGANAVNTMAEKVAPMIERLTGGRVLLRIISNLADRRLVRSWVKVYKEDIGGEEVVDAIVDAWAFAAADPYRAATHNKGIMNGVIAVALATAQDHRAIEAGAHAYAARTGRYMPLSTWEKDQDGNLVGTLEMPMAVGTIGGATKVHPVAKIALKILGVKTATELAEVMGAVGLAQNFAALRALATEGIQKGHMRLHARNLAIMAGATGDLIDRVVEIMVSEGKINFAYAQELVNKLSKEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ2</accession>
    <name>A1RYQ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase Iap family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752597.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0931"/>
    <dbReference type="EnsemblBacteria" id="ABL78332">
        <property type="protein sequence ID" value="ABL78332"/>
        <property type="gene ID" value="Tpen_0931"/>
    </dbReference>
    <dbReference type="GeneID" id="4600754"/>
    <dbReference type="KEGG" id="tpe:Tpen_0931"/>
    <dbReference type="eggNOG" id="arCOG02960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492316_0_0_2"/>
    <dbReference type="OMA" id="HEAPLEY"/>
    <dbReference type="OrthoDB" id="12236at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="1">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="211"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="539" mass="59631" checksum="FE9A9F94DFB7C59E" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR8</accession>
    <name>A1RYR8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thymidylate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752613.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0948"/>
    <dbReference type="EnsemblBacteria" id="ABL78348">
        <property type="protein sequence ID" value="ABL78348"/>
        <property type="gene ID" value="Tpen_0948"/>
    </dbReference>
    <dbReference type="GeneID" id="4601288"/>
    <dbReference type="KEGG" id="tpe:Tpen_0948"/>
    <dbReference type="eggNOG" id="arCOG01978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042142_0_0_2"/>
    <dbReference type="OMA" id="SQSAHIY"/>
    <dbReference type="OrthoDB" id="43367at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016741">
        <property type="term" value="F:transferase activity, transferring one-carbon groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="2">
        <location>
            <begin position="234"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="460" mass="51614" checksum="A1A81EB474ADE200" modified="2007-02-06" version="1">MRKDVEIVNTASNVAVVTLWTKKEVVVERLEKLGVLGKVYAVGTLYTKYGVNYLLHTLSTTPQVDVLVVFGADLMGSGEALVKLFKGEVDEGLKLLWSLEELKPLLSSVRVVDLREAFKRGDWGALARAIEENYRPGARRPAAPLRMEEVELESWPLQVAGLYVQETSLFRAWVKLVDAVMTWGFVKGSEYGERQRQLLGAVVVLDASQPLDERVYRYFPREDFERQAKSILEGEEGAVYSYGDRLRRHREAGDQVRRIVERLASSPDTRRAIALTWDFATDTNSQDPPCLVAVQGDLSGDTYNQVAFFRSHDAYAAWPLNAYGLLALMRRVAGELSERTGRAVKPGWLVVYSSSLHVYEHDWGRALRLVQENAAEARGAFVPDNKGNFLVRVEGGRIVAELRTPDGRLYRRYEGGSASEVLRQVGLDALMPGHAAYLSRELYRAEKALREGGEYVQDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU6</accession>
    <name>A1RYU6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752641.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0976"/>
    <dbReference type="EnsemblBacteria" id="ABL78376">
        <property type="protein sequence ID" value="ABL78376"/>
        <property type="gene ID" value="Tpen_0976"/>
    </dbReference>
    <dbReference type="GeneID" id="4600450"/>
    <dbReference type="KEGG" id="tpe:Tpen_0976"/>
    <dbReference type="eggNOG" id="arCOG00359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_2"/>
    <dbReference type="OMA" id="MEMPDYE"/>
    <dbReference type="OrthoDB" id="27688at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="10">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="676" mass="74793" checksum="51BDB5E7F47E423C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU7</accession>
    <name>A1RYU7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752642.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0977"/>
    <dbReference type="EnsemblBacteria" id="ABL78377">
        <property type="protein sequence ID" value="ABL78377"/>
        <property type="gene ID" value="Tpen_0977"/>
    </dbReference>
    <dbReference type="GeneID" id="4600451"/>
    <dbReference type="KEGG" id="tpe:Tpen_0977"/>
    <dbReference type="eggNOG" id="arCOG04938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590977_0_0_2"/>
    <dbReference type="OrthoDB" id="141195at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="167" mass="17771" checksum="CE114D008DCCD87B" modified="2007-02-06" version="1">MKLDIKNGQIVVYSAILGAAYTALGVAESALGMLNLLSPITDTPAGVPADILGGFAALVIGLAYLRGAIPLSRGSRESLGYILVGTFLSAIFGILYLLIVCADGLGALLALLEGEEWTWEWLTKGSAGPGLLRPEIWLFFASLPLAYLTWKNTKKIIQQPKNTGSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY0</accession>
    <name>A1RYY0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-cone domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752675.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1010"/>
    <dbReference type="EnsemblBacteria" id="ABL78410">
        <property type="protein sequence ID" value="ABL78410"/>
        <property type="gene ID" value="Tpen_1010"/>
    </dbReference>
    <dbReference type="GeneID" id="4600683"/>
    <dbReference type="KEGG" id="tpe:Tpen_1010"/>
    <dbReference type="eggNOG" id="arCOG03714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431715_0_0_2"/>
    <dbReference type="OMA" id="GWKPYEL"/>
    <dbReference type="OrthoDB" id="85037at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="187" mass="21168" checksum="D35D442E593039ED" modified="2007-02-06" version="1">MPKKVVKRSGKVEEFDREKLVRSMVNAGAPEEVAVEIAKEVESKVRDGATTDEIRRYVLARLKVLAPQAYEAWTFYDRVAKGRITFEDGKYVVVSKGHLYLGREVKDVGPKGLSSSEEVEGILKELEEDLEYGVSKATINARLYALFMGVLKSKAMPVEEKEKSIKLINSFREKLGWKPYELKKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY2</accession>
    <name>A1RYY2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752677.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1012"/>
    <dbReference type="EnsemblBacteria" id="ABL78412">
        <property type="protein sequence ID" value="ABL78412"/>
        <property type="gene ID" value="Tpen_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="4600685"/>
    <dbReference type="KEGG" id="tpe:Tpen_1012"/>
    <dbReference type="HOGENOM" id="CLU_2893459_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="62" mass="7095" checksum="2530894E61CA46BE" modified="2007-02-06" version="1">MGEEERREEDTASPFARLEYEEWLRHQNPHLGVEKSGVVVKLLLLLAGVGALLLVLYLVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ6</accession>
    <name>A1RYZ6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="4" type="ordered locus">Tpen_1026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1026"/>
    <dbReference type="EnsemblBacteria" id="ABL78426">
        <property type="protein sequence ID" value="ABL78426"/>
        <property type="gene ID" value="Tpen_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1026"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_2"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="59"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="254" mass="28805" checksum="FB101B37CC504B72" modified="2007-02-06" version="1">MFCPKCGDYVKPRVERSITPTGELVIEYHCPVHGLLETEKRRIFGDNKSRVDGGLYVALEGIDGSGKTTQAAMLYEKLSAEGFQVVIVREPWVPAIKEFLYKHDLDVEAEVYLFAADRIILQREVVLPSLRAGKIVVSDRSVFASLAYQSSRGADQDFILAVNKSVRFPDVVVLLDLPVEEAMKRLSSRVAQTRFEDPGYMEKVRAKYLQLAEEYPEKFIVVDASKPPEEVNREILREIVSIVRSRIRSEPGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ66</accession>
    <name>A1RZ66_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS system sorbose subfamily IIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_1097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1097"/>
    <dbReference type="TCDB" id="4.A.6.1.24">
        <property type="family name" value="the pts mannose-fructose-sorbose (man) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78496">
        <property type="protein sequence ID" value="ABL78496"/>
        <property type="gene ID" value="Tpen_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1097"/>
    <dbReference type="eggNOG" id="arCOG14869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116175_1_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-4" evidence="8">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="167" mass="18969" checksum="59A61735406A6C36" modified="2007-02-06" version="1">MEKKQNIFIRIDDRFIHGQVTAAWTKKFEANAIWVVNDKIAGNPALKQLQIMLAPPGISVEVLKVEEAAAKARNVGNNTRVLMLFENPIDVLAFIEKSGVKVDWILAGQMGYRAGRVKVEKTFDVGPEEHKALLRLLDMGIKVYYQQLPDFPPKPVDLEEKLRKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE1</accession>
    <name>A1RZE1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1173"/>
    <dbReference type="EnsemblBacteria" id="ABL78571">
        <property type="protein sequence ID" value="ABL78571"/>
        <property type="gene ID" value="Tpen_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1173"/>
    <dbReference type="eggNOG" id="arCOG01462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050524_0_0_2"/>
    <dbReference type="OMA" id="RRYSIVY"/>
    <dbReference type="OrthoDB" id="93979at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="437" mass="46459" checksum="0D1AB779248311CE" modified="2007-02-06" version="1">MRIRVLVAKEVKDTLRDPRIIIPFVISALILPVIGLAVSIPMKAAVQQAVEGAKVVAVIDLDRTAYSREFVEWLRSKLSVVELPADYAGNVEKAAEAASAKGASVILVLDKGFGESLSARRRAEVRVISVVDEIYFLAGVESSSVQRLVDDFALSKILEGTGIAPGVVRRPVNFSEETYVKAKGVALPYPPAALAGISMSVMLVPMIVLSMAMVVMQMSATSAAVENEEKTLETLLTLPVTSTEILLSKLAGMFIVSLVGSALEVIGLVLYLQTFAWAMTGPSAAEGLLGSAGGLSQFVGTGDVALLAASLVLSLLFSAAIGVMVGALSKDVRIASTLMSPIAMLVLIPGYIVAFAPSRFLGVYLKTLLYVVPVTQPVVMSRDIIGARVPPEAPLYLLASLTLSLAVMYLAGKFFSLETLSSLQYRVERIASRLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI7</accession>
    <name>A1RZI7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78617">
        <property type="protein sequence ID" value="ABL78617"/>
        <property type="gene ID" value="Tpen_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1219"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="68" mass="7558" checksum="2CFC6768FE4AEA49" modified="2007-02-06" version="1">MRAIGALSRLLASTLRRDGLYEARLIDALDAIEEFLASVRGAPQVKEDEKLARKLREGVEVLREHGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM2</accession>
    <name>A1RZM2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752917.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1254"/>
    <dbReference type="EnsemblBacteria" id="ABL78652">
        <property type="protein sequence ID" value="ABL78652"/>
        <property type="gene ID" value="Tpen_1254"/>
    </dbReference>
    <dbReference type="GeneID" id="4600420"/>
    <dbReference type="KEGG" id="tpe:Tpen_1254"/>
    <dbReference type="eggNOG" id="arCOG00936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_0_0_2"/>
    <dbReference type="OMA" id="TCVCFFG"/>
    <dbReference type="OrthoDB" id="54365at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="144"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="384" mass="42395" checksum="34EA37A68119B4DA" modified="2007-02-06" version="1">MWRISLYRKLWSSEKECKVCGKKSMLVSEAIGVCAECLRSDPGAVEVALEGHRKERASLGLPPDPPRDPRGTPCGLCNLGCRIPEGGLGYCGLVKNEGGRIVHLSGQPGSGVLEYYYDPHPTNCVAFWFCPGATGAGYPRYAVRPGCEEGYVNLAVFYGACNHNCAFCQNWFYRRNAVSRSPRVSVEELLEAALDPRVTCVCFFGGDPAPQVLHALAFTRELLERARGRIMRVCWESNGHFSPKILPRVIEASLRSGGTVKFDLKAWSPGIYRALTGVEQGSLLDNAGRVAEAAKERPEVPLFTASTLLVPGYVDEEEVRAIARFLASLSPDIPYTLLAFHPDHRMLDLPPTSRRHAEEAARVAREEGLLRVRIGNPWLLGDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS4</accession>
    <name>A1RZS4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1306"/>
    <dbReference type="EnsemblBacteria" id="ABL78704">
        <property type="protein sequence ID" value="ABL78704"/>
        <property type="gene ID" value="Tpen_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1306"/>
    <dbReference type="eggNOG" id="arCOG04017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149114_0_0_2"/>
    <dbReference type="OMA" id="RIRVGNK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="91" mass="10103" checksum="53AFCC874B2C25DA" modified="2007-02-06" version="1">MGLWPPPGDAREEVFETAGGPLRVWVARRAARVHVVAGGAESREVDVVVSPLADEPLISDVLAGELEIAVEDFARGLWRFRWEPREVLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS8</accession>
    <name>A1RZS8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1311"/>
    <dbReference type="EnsemblBacteria" id="ABL78708">
        <property type="protein sequence ID" value="ABL78708"/>
        <property type="gene ID" value="Tpen_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1311"/>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613819_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="78" mass="8563" checksum="DBAD9D3781B226E4" modified="2007-02-06" version="1">MGNLVRAVGMLEGCPELSMLIPEVRSNIVYALPNPRTVRDVAGVEGRITVVNGRPKASSYPRFGASWHMARLIVEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT6</accession>
    <name>A1RZT6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752981.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1319"/>
    <dbReference type="EnsemblBacteria" id="ABL78716">
        <property type="protein sequence ID" value="ABL78716"/>
        <property type="gene ID" value="Tpen_1319"/>
    </dbReference>
    <dbReference type="GeneID" id="4601999"/>
    <dbReference type="KEGG" id="tpe:Tpen_1319"/>
    <dbReference type="eggNOG" id="arCOG02656">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607246_0_0_2"/>
    <dbReference type="OMA" id="QDAYELT"/>
    <dbReference type="OrthoDB" id="129025at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="165" mass="17590" checksum="D9CD998671BC68F7" modified="2007-02-06" version="1">MSGLPEPFEEALRVCTAVRDLCGGAEGCGESFQRRVEDFPGLVSAAGLVPALAFYLSKVEDYGVLRDFYSLFSSGSLPRDARREKMLEDLREEGLGYASALAAILAYAARQAPAGCSLKLDGDAARGVAEFLDCIRRGGGELVVLATLEPFVVELGKLARALLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU4</accession>
    <name>A1RZU4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752989.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1327"/>
    <dbReference type="EnsemblBacteria" id="ABL78724">
        <property type="protein sequence ID" value="ABL78724"/>
        <property type="gene ID" value="Tpen_1327"/>
    </dbReference>
    <dbReference type="GeneID" id="4601566"/>
    <dbReference type="KEGG" id="tpe:Tpen_1327"/>
    <dbReference type="HOGENOM" id="CLU_443225_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="616" mass="67003" checksum="242FDE251B3FFCC0" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU8</accession>
    <name>A1RZU8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752993.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1331"/>
    <dbReference type="EnsemblBacteria" id="ABL78728">
        <property type="protein sequence ID" value="ABL78728"/>
        <property type="gene ID" value="Tpen_1331"/>
    </dbReference>
    <dbReference type="GeneID" id="4601306"/>
    <dbReference type="KEGG" id="tpe:Tpen_1331"/>
    <dbReference type="HOGENOM" id="CLU_1709235_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="153" mass="16417" checksum="2ACAEFB64655D4DF" modified="2007-02-06" version="1">MKTKLRKYAAYAAFTVINGWLWAIAITAIVVAANMHAGFSADPLVKRYQAAGYTEYSATPILFAATFATSALAITKARDKRKVYYLAPALAIAITIIAIGLVTALIIDRSAQSCKDMCGPNGVEYWSVRGPYINLNGSITVDTGGTVCRCRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV3</accession>
    <name>A1RZV3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1336"/>
    <dbReference type="EnsemblBacteria" id="ABL78733">
        <property type="protein sequence ID" value="ABL78733"/>
        <property type="gene ID" value="Tpen_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1336"/>
    <dbReference type="eggNOG" id="arCOG01211">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149109_0_0_2"/>
    <dbReference type="OMA" id="DINVVYM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="13394" checksum="C73F755ABC68243E" modified="2007-02-06" version="1">MSRVRLREVLRCGALEDLVPGLERVVDELVERYRPLEVIVAGSLARGEFVRGLSDVDILVVVEREVSDSERFALRSVGDVDVEVTVVSRRELEEAVAAGNPFYAEAFERGVRVYSSKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV4</accession>
    <name>A1RZV4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1337"/>
    <dbReference type="EnsemblBacteria" id="ABL78734">
        <property type="protein sequence ID" value="ABL78734"/>
        <property type="gene ID" value="Tpen_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1337"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="8073" checksum="9F20C275ADAABA1C" modified="2007-02-06" version="1">MFSVRCWWRGVTVSFRIPGELKRRMDELGGRVDWGEEVRRFLERRVEELEQAKAVEDLEKVIASLPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV6</accession>
    <name>A1RZV6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78736">
        <property type="protein sequence ID" value="ABL78736"/>
        <property type="gene ID" value="Tpen_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1339"/>
    <dbReference type="eggNOG" id="arCOG02222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2949496_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="59" mass="6570" checksum="16770A6D65E16720" modified="2007-02-06" version="1">MRAGELKKRLRIALPDCYTIATAQALDATPLFRAPEKEMIPVLEALRKAGVKFLDEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY0</accession>
    <name>A1RZY0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753025.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1363"/>
    <dbReference type="EnsemblBacteria" id="ABL78760">
        <property type="protein sequence ID" value="ABL78760"/>
        <property type="gene ID" value="Tpen_1363"/>
    </dbReference>
    <dbReference type="GeneID" id="4601188"/>
    <dbReference type="KEGG" id="tpe:Tpen_1363"/>
    <dbReference type="eggNOG" id="arCOG03223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835818_0_0_2"/>
    <dbReference type="OMA" id="DVFIVEW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="332" mass="34890" checksum="51F5ECF411ED423E" modified="2007-02-06" version="1">MLEAFRVDFEKGFRVGYRRPERVVPAAAVLRALASVASMTGDTGLLRAVLEGRVAASAILPALHDGGRLVPLVPLAPQGVVHASLSKSAGLGRKVRLYATLGGARRLAEALDTAGCGVAPCAELVGELSKRLKVVVLKGGDAVLVDDGEEAAVAGATPTDVGLAAEHRNAIDRLTSSANPFLVTYAKPRGPMVLLVEHEGLDVERALKLLGELGLGGLRSRGLGRFTARKIDLGESRGVAPLPRASTGRYAVSLGEVPLSSDAVDWRRSFFELSVITGYVGPPYAQRLARPIAASRAGASLYVAKRKYERVEVGSEDVPSTFVFNPLLVQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S002</accession>
    <name>A1S002_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753047.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1385"/>
    <dbReference type="EnsemblBacteria" id="ABL78782">
        <property type="protein sequence ID" value="ABL78782"/>
        <property type="gene ID" value="Tpen_1385"/>
    </dbReference>
    <dbReference type="GeneID" id="4600668"/>
    <dbReference type="KEGG" id="tpe:Tpen_1385"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686287_0_0_2"/>
    <dbReference type="OMA" id="WFALTTI"/>
    <dbReference type="OrthoDB" id="62842at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="405" mass="41214" checksum="F8A840AC29203461" modified="2007-02-06" version="1">MSAERRFRFAVSYVPVFVARIGSGANTFLVAMLASGGDVAAGFVMAAYPLMEAIGALLAGSWSDFAGRKRTLIAGYVARSAGMLSLAAVFALSSSSPGSLVFAALEAALNGVVGFTTALILVSSLSMATDLTETGNRGLGMGGFEFVNLASYGAGYLLGSLLYSVLPGYPAYLAVALLTALATPVFAAFLEETRPPVPLVRRGLLSSLPRSALVLLPVWVALTTIIGIGIYAPRVIHDHLGAVHGPAIGKAGIGLLFLGALVLLGSGAVFFGRLSDSWGRVKVFRLGLAGGLAALSAMSVLLALGVDILRAAAAVAPLMFLTSAVGPTILALVGDQASTDARGRVMGVYSVVLGLGMGLGSILAGLASSALPYNRPLALSLVALAAYSVAALAHLYLERRLGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S016</accession>
    <name>A1S016_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1399"/>
    <dbReference type="EnsemblBacteria" id="ABL78796">
        <property type="protein sequence ID" value="ABL78796"/>
        <property type="gene ID" value="Tpen_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1399"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985607_0_0_2"/>
    <dbReference type="OMA" id="FTYYFVG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="30062" checksum="457F9F85ED46C7EB" modified="2007-02-06" version="1">MKKTRHAFFAVASGVLVKEAKIMTRYVGSLLMVVFMPFALGGLYIGVGLALAGPGALGNFQGNTGVSNPVLYFTLGGVLMVSSMIMIENTSSIIREEQLMGTFELHYLTPNSTVALWMLHALASSLLSVLIFALDVSIVALSGFRGVSAADWLLAFLVVLVGLLPLAGLGLVVAALTVRFKEVYAVSQTINAFVAMLSGFYYPLEVFPRVVRVAAALLPTSHASEILRELFGGTGQEVPIHFRIAAMFLLAVLYLYAGRTVYNRWEEGARRNGELSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S065</accession>
    <name>A1S065_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1448"/>
    <dbReference type="EnsemblBacteria" id="ABL78845">
        <property type="protein sequence ID" value="ABL78845"/>
        <property type="gene ID" value="Tpen_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1448"/>
    <dbReference type="eggNOG" id="arCOG03743">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145188_2_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022274">
        <property type="entry name" value="Peptidase_asp_AF0612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03698">
        <property type="entry name" value="clan_AA_DTGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="12605" checksum="F0E15DB3CE7C4CDF" modified="2007-02-06" version="1">MGHVYAPVKLYHGEKSLEVKALVDTGATTLVLPRSVAEELGLRVLGKMDVELADGTVKKVDYSIVEVELSGRRAPVLVAIVERGEVCVGVEALERLGLAVDPATGSIYSTRRFVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1S075</accession>
    <name>A1S075_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha amylase, catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753120.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="SMR" id="A1S075"/>
    <dbReference type="STRING" id="368408.Tpen_1458"/>
    <dbReference type="CAZy" id="CBM34">
        <property type="family name" value="Carbohydrate-Binding Module Family 34"/>
    </dbReference>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78855">
        <property type="protein sequence ID" value="ABL78855"/>
        <property type="gene ID" value="Tpen_1458"/>
    </dbReference>
    <dbReference type="GeneID" id="4600584"/>
    <dbReference type="KEGG" id="tpe:Tpen_1458"/>
    <dbReference type="eggNOG" id="arCOG02948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_4_2"/>
    <dbReference type="OMA" id="TPDWVKH"/>
    <dbReference type="OrthoDB" id="5581at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="223"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="644" mass="74259" checksum="C65E57A0A82BB234" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A7</accession>
    <name>A1S0A7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1490"/>
    <dbReference type="EnsemblBacteria" id="ABL78887">
        <property type="protein sequence ID" value="ABL78887"/>
        <property type="gene ID" value="Tpen_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1490"/>
    <dbReference type="eggNOG" id="arCOG00188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="QFRRIQM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="212"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="245"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="408" mass="43511" checksum="353203FCB8C8CC2F" modified="2007-02-06" version="1">MSVGGKSILEGLSFEVEEGELAVVTGPTGSGKTTLLKVLAGVIPGLYDSYRVTGSVKVYGLDPLEAAGRGLVAYVPQDPHYYFLGVTVGEEVALAGGVAGFAEHLLRYPSRRIDELSDGELYRLLAATALSGGAKLLLLDEPTARVDPWGLGEVLETLSELGEERGLTTLLVEHRVDLVKSYASRVITLGDARAGATPPARVAGRAGARVKVYADKLAYAYERGRPVLRGASLRVREGECVAVTGRNGSGKTTLLKILAGILKPSAGTLLVEKPVFLVPAAPLYWYSSASVEEEVELFAEAWGFRGDVGEVLELFDLERLGGRNPYELSAGESRRLSLALAYVSRAETLLLDEPTLGLDAPSKRALLEMLEEFASRGSSVVVATHDLAFASLLDRVLELRGGVLEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D1</accession>
    <name>A1S0D1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753176.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78911">
        <property type="protein sequence ID" value="ABL78911"/>
        <property type="gene ID" value="Tpen_1514"/>
    </dbReference>
    <dbReference type="GeneID" id="4601110"/>
    <dbReference type="KEGG" id="tpe:Tpen_1514"/>
    <dbReference type="HOGENOM" id="CLU_091236_0_0_2"/>
    <dbReference type="OrthoDB" id="143423at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="253" mass="26542" checksum="AFCB6EEF3EA5CF9C" modified="2007-02-06" version="1">MSEKAGFYVDGMRLLKGYSEAMLASQLVNLVALLVFALLLPGFLPSVPELWAGKEALRLGAALARHLLLLLLVLILFIAGGVLWLFAVFARLIPAADRLAKWREALGGSSKMIKYGYWASLALAVLAVVALVAFALPAMPALAGRYPPVGPEAMLAVMTGFIVVLLLVVLAAIASFVARIGEILMLFELSSATGLDSFKTAAILEVVQILLSFLSAVPHALAVAGLLSVALFIAALVLIREGSAKALAQPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F4</accession>
    <name>A1S0F4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753199.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1538"/>
    <dbReference type="EnsemblBacteria" id="ABL78934">
        <property type="protein sequence ID" value="ABL78934"/>
        <property type="gene ID" value="Tpen_1538"/>
    </dbReference>
    <dbReference type="GeneID" id="4600380"/>
    <dbReference type="KEGG" id="tpe:Tpen_1538"/>
    <dbReference type="eggNOG" id="arCOG02828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059741_0_1_2"/>
    <dbReference type="OMA" id="LTVGTDM"/>
    <dbReference type="OrthoDB" id="28941at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035402">
        <property type="entry name" value="DUF1611-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035086">
        <property type="entry name" value="DUF1611_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011669">
        <property type="entry name" value="UCP026760"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40690">
        <property type="entry name" value="PTHR40690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07755">
        <property type="entry name" value="DUF1611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17396">
        <property type="entry name" value="DUF1611_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026760">
        <property type="entry name" value="UCP026760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1611_N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1611" evidence="1">
        <location>
            <begin position="144"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="38865" checksum="58557047857145E2" modified="2007-02-06" version="1">MEEGEAVILAEGLYSTTDGKTAHGLVRKSLRYKIVGVIDSTLAGRDAGEVLDGKPRGIKIYSSLEEALKEHPGVKFLIIGVATPGGRLPPSYREVVKEALKRGISVVSGLHEFLSDDPELSRIARETGAEIIDVRKIYYNTRKFYTGKIKEVKALKVVVIGTDSAVGKRTVAHMVTDELNARGIKAVFVGTGQTAWMQGAKYVFVLDSVINDFVPGVLEDVVWRAYSEEKPKVIVVPGQGSLLHPVFPGSYEILNLLKPEVTILHHAPGRKHLDGFPEYPVPPLEKFLKLVEIITDRRVFAITLSTEGLSEREVLAEREKLEKELGIPVVVPMIEGVGRIVDEITRRFPEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F6</accession>
    <name>A1S0F6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753201.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1540"/>
    <dbReference type="EnsemblBacteria" id="ABL78936">
        <property type="protein sequence ID" value="ABL78936"/>
        <property type="gene ID" value="Tpen_1540"/>
    </dbReference>
    <dbReference type="GeneID" id="4600833"/>
    <dbReference type="KEGG" id="tpe:Tpen_1540"/>
    <dbReference type="eggNOG" id="arCOG04797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130792_0_0_2"/>
    <dbReference type="OMA" id="HADMQPF"/>
    <dbReference type="OrthoDB" id="120740at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="170" mass="18271" checksum="8D99333BF0138639" modified="2007-02-06" version="1">MPFTPFHLGPALAVGLPLRERIHAPTFILASIAVDVEPLVVLVLGLDYPLHGYLHTFAGAALLGLCLGLLMHATEKVLGNAWKRALLEGSRSVGFEGFAVAGILGCTVHVLLDSPLYPDIRPLYPYAANPLYDPSLTPAVYLLCSVLLLGGLAYYLYLALQHQAKQGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H7</accession>
    <name>A1S0H7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1562"/>
    <dbReference type="EnsemblBacteria" id="ABL78957">
        <property type="protein sequence ID" value="ABL78957"/>
        <property type="gene ID" value="Tpen_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1562"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187831_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="25485" checksum="76DF1592ADF15E11" modified="2007-02-06" version="1">MPGEADRAAMSRVEEVLASLGFSRYEIKAYLALLIRGVATVSEVADLSGISYTKAYDVLSSLENKGLLASVPGRPLRFQALDPETAMRNLLERRRSELLGEIKRLEEKVSEATSELRKLYSPEARSPVFLVRGERALPTLVQEALRSAEATVVCSDASKVFGERDAELLRRRVNVVELGGGEPAALLVEPGRVEVYVKEDVEANSYTVVVNSERLAGLLLRLLEALRGSGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K3</accession>
    <name>A1S0K3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753248.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1588"/>
    <dbReference type="EnsemblBacteria" id="ABL78983">
        <property type="protein sequence ID" value="ABL78983"/>
        <property type="gene ID" value="Tpen_1588"/>
    </dbReference>
    <dbReference type="GeneID" id="4600552"/>
    <dbReference type="KEGG" id="tpe:Tpen_1588"/>
    <dbReference type="eggNOG" id="arCOG00149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654913_0_0_2"/>
    <dbReference type="OMA" id="KPGFWYR"/>
    <dbReference type="OrthoDB" id="33798at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="49764" checksum="5F923ABFF45B2DBA" modified="2007-02-06" version="1">MSQQQNRLVLASIAVGIIALLVSLYAVVTVQSLASAISDLKASISNLQGTVSSLQQQVGKISQQPAPTTPPVQKVKLVVIGPWAGDEAKYFQAVIDAYVKTHPNVEIEYRTMRAEDVAATMPIQFAAGVAPGDVIFGWAWFIAKMGKEGHLVDLTGIIKENEYVPGIVDAVKADGKIWGAPFTMWLKPGFWYRKSFFQKYGLTEPKSYAEFVQLLEKIKGIPGVKNPIATGDGVGWPISDIVEHFIIAYGGPQMQLNLISGKTRFTDPSVRKVFSDYLIPLLQKGYFSEPIEWTTVIPKWWAGEYGLYFMGTWITGMVEDPNDLDFFPLPESKGVVGGADYAFVPKYSRNVDAALDFIKYLATEGQVVHASVPSGKIPTWTKAPVEKLWKPMQSVYTKITGKGLAILPDLDDSIGGDWQKLFWDQLKLLWVNPGALDSVLKTLESSQPKPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L1</accession>
    <name>A1S0L1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78991">
        <property type="protein sequence ID" value="ABL78991"/>
        <property type="gene ID" value="Tpen_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1596"/>
    <dbReference type="eggNOG" id="arCOG01199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766314_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="7696" checksum="BA7AE08E33E11409" modified="2007-02-06" version="1">MSEYAKRAVERGALAVILIGSLARSDYTAFSDADVVVVVERDCRRPMDRALDFLDPTLSTDLEPSLHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P5</accession>
    <name>A1S0P5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable inosine/xanthosine triphosphatase</fullName>
            <shortName evidence="2">ITPase/XTPase</shortName>
            <ecNumber evidence="2">3.6.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Non-canonical purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Non-standard purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleoside-triphosphate phosphatase</fullName>
            <shortName evidence="2">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + ITP = H(+) + IDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + XTP = H(+) + phosphate + XDP</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YjjX NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753290.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1630"/>
    <dbReference type="EnsemblBacteria" id="ABL79025">
        <property type="protein sequence ID" value="ABL79025"/>
        <property type="gene ID" value="Tpen_1630"/>
    </dbReference>
    <dbReference type="GeneID" id="4601033"/>
    <dbReference type="KEGG" id="tpe:Tpen_1630"/>
    <dbReference type="eggNOG" id="arCOG01221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087417_0_1_2"/>
    <dbReference type="OMA" id="ADYWVGI"/>
    <dbReference type="OrthoDB" id="101951at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00258">
        <property type="entry name" value="TIGR00258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTPase_I-T" evidence="3">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="181" mass="19371" checksum="BAF988B55DD87160" modified="2007-02-06" version="1">MRVVVGVGSANPSKIAGVEKAFKRYFGDVVVKGFRVESGVARQPFSLGEILRGARNRALRALEACGECAFGVGVEAGIFAVDGFYMDTQAAVVVKRGGAEGVGFSSSFAVPPFIVEEILSEGLELEEAVDRHFGTRNVGEGEGFVGLLTRGVVVREDLAEQAVLMALIPVLNEELYFRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q6</accession>
    <name>A1S0Q6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753301.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1641"/>
    <dbReference type="EnsemblBacteria" id="ABL79036">
        <property type="protein sequence ID" value="ABL79036"/>
        <property type="gene ID" value="Tpen_1641"/>
    </dbReference>
    <dbReference type="GeneID" id="4600920"/>
    <dbReference type="KEGG" id="tpe:Tpen_1641"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_2"/>
    <dbReference type="OMA" id="GFGMSPK"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="486" mass="51499" checksum="13F2553D12A5AD5A" modified="2007-02-06" version="1">MDTAHKKYLLTALSITTLGAFMAGLDARIVVVGLDVIASALKADIEEALWFTQAYMLGSTLMLLLAGKLADLYGRVKLYAYGFLLFTLGSILSGAAATPLQLAASRFLQGLGAGVLTTLSATIITDVAVGGPLAFALSINSLAFRLGSILGLTASGLIIGLLGWRGIFYVNVPVGIAGAILSRKRLRETYTPREKPLIDWVGFCLFTVSLLGLLLALTFYAYGLSYRSFARLLLLVSAACFLLFIAVEARSDHPILDLSLFRIWGFTGGNIAQFLNAVAFGAVMLLLTLYYEVALRKSAFETGISLLPFELSFLAFGLLSGRLSDRYGYVKFAILGLLVGSLAQLLLGGLTVSTSPALVAAYSALLGAGNGLFLSPNTSAIMSSVPPERRGVASAIRAIVFNVGMTISLNIAVILISTRIPYETVTQLLVGAELMTSDTATSRALLVDAIAYTFRVLALVNLSAALFSFTRLKGGKTGRALPVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q9</accession>
    <name>A1S0Q9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753304.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1644"/>
    <dbReference type="EnsemblBacteria" id="ABL79039">
        <property type="protein sequence ID" value="ABL79039"/>
        <property type="gene ID" value="Tpen_1644"/>
    </dbReference>
    <dbReference type="GeneID" id="4601658"/>
    <dbReference type="KEGG" id="tpe:Tpen_1644"/>
    <dbReference type="eggNOG" id="arCOG00844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040596_0_0_2"/>
    <dbReference type="OMA" id="WSNITEP"/>
    <dbReference type="OrthoDB" id="95927at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="27601" checksum="83FDD87EEAE0573D" modified="2007-02-06" version="1">MLSVRSSRRIVLVAERGSEVLGFVIAYKHRERAYVDSLAVDPAYRDLGIGGRLLSGLEELLAKRGVERIALSVKDSNLRALDFYLRRGYGVVGLILFMYARTGSLPAEAPPGYELRLRDAPLRGRLKRYKPTTMWSTLTEPVDRMIYKKYGAGEKTLTAYKSGRVRGVAEFSADDEVFADYVALSSYSSVEALRALLKGFRDFGLEAGIDTLVIPVDSSKQVVVEELSRSGFRTLKTEYLLEKELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R5</accession>
    <name>A1S0R5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753310.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1650"/>
    <dbReference type="EnsemblBacteria" id="ABL79045">
        <property type="protein sequence ID" value="ABL79045"/>
        <property type="gene ID" value="Tpen_1650"/>
    </dbReference>
    <dbReference type="GeneID" id="4601727"/>
    <dbReference type="KEGG" id="tpe:Tpen_1650"/>
    <dbReference type="eggNOG" id="arCOG01096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065373_1_0_2"/>
    <dbReference type="OMA" id="ADDEMRH"/>
    <dbReference type="OrthoDB" id="26612at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01044">
        <property type="entry name" value="Ferritin_CCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039376">
        <property type="entry name" value="Ferritin_CCC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="290" mass="31958" checksum="DD2B1A5E71DC92E9" modified="2007-02-06" version="1">MPFAEYALDELFDSELYRRLAGIEKNPANREILEKLSQQERSHYEFWSRFSGSVELGRWDRLKLAFLVLSSRILGKVFIIKFLERHEGRVVEEYVRVLESAGLSEEQREALKGIIEDEKYHEEALASQIDEFAVRHLGAMALGMSDAIIELSGVHAGFLGYTSSPIYTGISGLIVGISASMSMAAAAYLQAKQEKGKSPAVNALVTGLMYMLTVVMLTSPFFLVPSVATALAASVALAVAALAAFSYFSSVILGGNFLREFLENTSIVFLVVLVGYLFGSLVERVFGFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R9</accession>
    <name>A1S0R9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753314.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1654"/>
    <dbReference type="EnsemblBacteria" id="ABL79049">
        <property type="protein sequence ID" value="ABL79049"/>
        <property type="gene ID" value="Tpen_1654"/>
    </dbReference>
    <dbReference type="GeneID" id="4601731"/>
    <dbReference type="KEGG" id="tpe:Tpen_1654"/>
    <dbReference type="eggNOG" id="arCOG01772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055583_0_0_2"/>
    <dbReference type="OMA" id="EHNSFAS"/>
    <dbReference type="OrthoDB" id="76035at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="413" mass="44089" checksum="4FB367A92EDA50FB" modified="2007-02-06" version="1">MNVYAVAFASRIHGEGYYRQAYSYVSSVLRVPVYPEVVAERDTLKKAVEELRGSLPLAVVLTGGTSGLIQEFASEGGFRAVALLAQGEHNSLASAISARAALESRGVGVALFHCGSFSDGNCAAAASAAVRVARGAGRVLGARVGVVGSKPRYADVFSSRLGWTIEVVPAEELFSAAESAPREAVESFLSRVSGVPGFELYRSSLEHVGGVYYALRRLSEEKRLDAVAVDCFPYLVEHRVSPCVALALLNADGFAAACEADLYSALLMLVSRELTGSSGWIANATHFEGRVGVFSHCTIAFDIARAPSLVDHFESGYPVAVASQLQPGEVTVASLSRDLSEVYVARGRVVRSGFISRAMCRTQAHVEFDFDAEVIPLVAPANHHLVMPGDVVREVKSVSKLLGLRVKEYSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X2</accession>
    <name>A1S0X2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1707"/>
    <dbReference type="EnsemblBacteria" id="ABL79102">
        <property type="protein sequence ID" value="ABL79102"/>
        <property type="gene ID" value="Tpen_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1707"/>
    <dbReference type="eggNOG" id="arCOG07703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299491_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="100" mass="11289" checksum="DEFE9AC7DD48ABDE" modified="2007-02-06" version="1">MLRNIRFGWKGISTPEFIVEWGVSVVGARKKVVVEVPCFVGEEDVVRAVEEVLCEKYGVVAVDALRRRLGVTELREDVPVYEDVAVLREKEGKRVVSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S129</accession>
    <name>A1S129_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753424.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79159">
        <property type="protein sequence ID" value="ABL79159"/>
        <property type="gene ID" value="Tpen_1764"/>
    </dbReference>
    <dbReference type="GeneID" id="4601941"/>
    <dbReference type="KEGG" id="tpe:Tpen_1764"/>
    <dbReference type="eggNOG" id="arCOG11225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2434027_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="10911" checksum="D0521C914A0992B7" modified="2007-02-06" version="1">MAFAWRRYWRAGWGGWGYPPYYGYPPAMPPWAPPMSPEQELRYLEDYRRWLEEYRKSLEEEIKGVEEELKEVDSRIEELRRMLGRGATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S133</accession>
    <name>A1S133_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753428.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1768"/>
    <dbReference type="EnsemblBacteria" id="ABL79163">
        <property type="protein sequence ID" value="ABL79163"/>
        <property type="gene ID" value="Tpen_1768"/>
    </dbReference>
    <dbReference type="GeneID" id="4601945"/>
    <dbReference type="KEGG" id="tpe:Tpen_1768"/>
    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_2"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="OrthoDB" id="85146at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="175" mass="19225" checksum="FBDA40110F3680D8" modified="2007-02-06" version="1">MTGEPRVLRDELLCEGRRVKLYRRVVSAGDAEVEKDYVAFGESVVVVPVLEGGALVFVRQWRPAINRWIVELPAGRVELGEGVLEAAGRELEEETGFKAGALREVGSFYVSPGYSDELIHVVVAERLVAAKAHPEPGEVLSVVVMRPEEYLSRVGRESLDLKTVAAIHLYLGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S136</accession>
    <name>A1S136_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753431.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1771"/>
    <dbReference type="EnsemblBacteria" id="ABL79166">
        <property type="protein sequence ID" value="ABL79166"/>
        <property type="gene ID" value="Tpen_1771"/>
    </dbReference>
    <dbReference type="GeneID" id="4601948"/>
    <dbReference type="KEGG" id="tpe:Tpen_1771"/>
    <dbReference type="eggNOG" id="arCOG05461">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272814_0_0_2"/>
    <dbReference type="OMA" id="DWYKYSA"/>
    <dbReference type="OrthoDB" id="3526at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1111" mass="117719" checksum="597C103D347C3841" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S146</accession>
    <name>A1S146_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753441.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1781"/>
    <dbReference type="EnsemblBacteria" id="ABL79176">
        <property type="protein sequence ID" value="ABL79176"/>
        <property type="gene ID" value="Tpen_1781"/>
    </dbReference>
    <dbReference type="GeneID" id="4601925"/>
    <dbReference type="KEGG" id="tpe:Tpen_1781"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OMA" id="EIYPGFN"/>
    <dbReference type="OrthoDB" id="17407at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="295"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="408" mass="46279" checksum="6C90B115E8ED73C3" modified="2007-02-06" version="1">MGERAAATCLQCRGAKRLCGKSSCPVLDLWLALERVRVPETREIDGYSPPTVFVGRHGYPEVRFSVGVPSIEGDPALFEDQERWLSMPLRDVIGMRLGIVRGEVRVKVDGRGLSDEVRLAALSSRPVDVEILLEKAPRARPLVDLFSPPLGPAGPAAKISVLGNPSVPRSLEKAYYDYDLGAREAIYALYREGVPVHYIQRALSVGALGLGGRRRIVPTRWAITAVDSTLSQELIEEVKRLDYFDEYLFFERKFSDNTFVAIIAPGAWSYEWIEAWFPHTTWNPSARLEVEGDWEGFKGRTTYASLGGCYYAARLATAEFMLREKRQGTAILLREIYEGFFLPIGVWFVRENVRELFRSKPERYESLEEVLRRLEKSTRLPLGTWLAASTLLRRLLRQSSIEAYIWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S155</accession>
    <name>A1S155_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1790"/>
    <dbReference type="EnsemblBacteria" id="ABL79185">
        <property type="protein sequence ID" value="ABL79185"/>
        <property type="gene ID" value="Tpen_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1790"/>
    <dbReference type="eggNOG" id="arCOG02180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077329_0_1_2"/>
    <dbReference type="OMA" id="GMGCHEC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="229" mass="24569" checksum="00399C8A15AB739E" modified="2007-02-06" version="1">MLYPLFHSFSLESLNSWFDWFLTNTMSGDEAFNVTKKQSFRVTRRDFVFFVAKVAVLTGIVTSVPLVAAKTVDKRRPPGAVDEAEFVVVCARCGRCAEVCPQKIIVQVPVWESVVAAGTPVLVDGGVCVLDFKCVDVCPTGALQRLPKEKAKMGTALLDKDKCIGCGACVSVCASIAGAIKWRKSGRKVEVDAAKCLGCGACVKECPVGALSLTPSGAYRPSWKWPKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S183</accession>
    <name>A1S183_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar fermentation stimulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753478.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1818"/>
    <dbReference type="EnsemblBacteria" id="ABL79213">
        <property type="protein sequence ID" value="ABL79213"/>
        <property type="gene ID" value="Tpen_1818"/>
    </dbReference>
    <dbReference type="GeneID" id="4602055"/>
    <dbReference type="KEGG" id="tpe:Tpen_1818"/>
    <dbReference type="eggNOG" id="arCOG04115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052299_1_0_2"/>
    <dbReference type="OMA" id="VTAHCPN"/>
    <dbReference type="OrthoDB" id="97928at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="1">
        <location>
            <begin position="85"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="234" mass="26026" checksum="2122E99F36F94F04" modified="2007-02-06" version="1">MTWRLVRLPEPSECRVIRRENRFVVLVEVEGRAYRAHINNTGRLLEFLVPGRRAFCLRRERSKTAYRLFAVEDAGSAALIDTALQMNALESLFEQGIEPWSGCSVKARAPRLGSSRLDYLLVCNGEEVFVEVKSAVLREDSYAMYPDCPTLRGRRQISELIRLAEGGGKAMIIFVAALPGVKAFKPYGEGDPEVAVLLGEAKKKGVVLRAVALHYDPSQSEIVLDDPDLPVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S185</accession>
    <name>A1S185_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753480.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1820"/>
    <dbReference type="EnsemblBacteria" id="ABL79215">
        <property type="protein sequence ID" value="ABL79215"/>
        <property type="gene ID" value="Tpen_1820"/>
    </dbReference>
    <dbReference type="GeneID" id="4602057"/>
    <dbReference type="KEGG" id="tpe:Tpen_1820"/>
    <dbReference type="eggNOG" id="arCOG00532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068199_0_0_2"/>
    <dbReference type="OMA" id="HCGYNCK"/>
    <dbReference type="OrthoDB" id="62565at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="246" mass="26500" checksum="D960F331E5CF1443" modified="2007-02-06" version="1">MRAVAVIGFKGSGKTTVASYIVGELKRRGLRVAAVKHAHGGISVNDEDSGRLFGAGADRVIAVSDDVVEEYRRSRASLWEVISQLRGFDFAVFEGFKSEFPGVRLAVARNVEEARELLTPLTVAITGRVAKEDHSGLPVPVFDLESEGERLVDFLLEKAFEPLPGLNCGFCRYGSCVALAEAVARGEAGHGECTVLSSKVKLLVDGKPVELNPFVQDVFRNVVFALVGSLKGVGSSPSRVELRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S190</accession>
    <name>A1S190_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide peptidase SppA, 36K type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753485.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1825"/>
    <dbReference type="EnsemblBacteria" id="ABL79220">
        <property type="protein sequence ID" value="ABL79220"/>
        <property type="gene ID" value="Tpen_1825"/>
    </dbReference>
    <dbReference type="GeneID" id="4602062"/>
    <dbReference type="KEGG" id="tpe:Tpen_1825"/>
    <dbReference type="eggNOG" id="arCOG01311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046540_0_0_2"/>
    <dbReference type="OMA" id="YVYDEIR"/>
    <dbReference type="OrthoDB" id="36138at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="109"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="307" mass="33014" checksum="AF041E9EBF5240B7" modified="2007-02-06" version="1">MSGLKEVLRRRLPLLLIVAVVILGAVLVLLRQGATQTRLTPYIAQITIKGTIDYASSSIFGATPGVEEYIKLVKQAEEDPMAKAVLLVFDSPGGTVTASDELYQAVKELSQKKVVVSYAKGLLASGAYMAALPSRAILASPTSEVGSVGVIVTVLNVGNLLGKIGVTVYTFKSGELKDVGSPYRPMTEEDAKVLEEMVNYYFGLFKGRVLEHRGNVSSEVFSGRPFTPDKALQAGLIDKVCTYQEAVNYTRALANLPETAEVVELKPRTPTLLDLLLGTYSGAGNRLVIPSIVVLYMWPPPVAVILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S196</accession>
    <name>A1S196_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753491.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1831"/>
    <dbReference type="EnsemblBacteria" id="ABL79226">
        <property type="protein sequence ID" value="ABL79226"/>
        <property type="gene ID" value="Tpen_1831"/>
    </dbReference>
    <dbReference type="GeneID" id="4602068"/>
    <dbReference type="KEGG" id="tpe:Tpen_1831"/>
    <dbReference type="eggNOG" id="arCOG00146">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634046_0_0_2"/>
    <dbReference type="OMA" id="FFRYNEK"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="430" mass="47571" checksum="DE83CF38AB6D2569" modified="2007-02-06" version="1">MLTRKQRVAYGFARFGSTIFMGLYDFASFYIYWQVFRLDPLLSGYMGAIGKITIMVASLLVGYLSDSIWTRWGRRKPFIATGAPLLAFSGFLHFTPIYFLQGATQEALFLWGAATSSMFHFFYAWLLTPFQAWLPEISEPSERIDISMLQNVANILGNIVSTVTGFLAKMLVARGLLMPLVGAYALVLVALFTPPVVLLPVERRAEPTRPSLKDLLTVFRYREYMKWMAVRGLMSSSVQMLTITIIAYIEKVIGVEHSLASASFGVILVVFVAGAFPLWGRLGKRAGKGRALTLSMTLLGATLLMTPLPHFVDPGVFRVLLGYVLVALGAVAVSAYVLFPYAVLADLAHWYEVQTGEKRAGLFTGFEGIPINVFESLAYLVTGFLMSLPQVPGSEYTYGLILWGPVASLFTLVALAILRRTNVDPFLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C3</accession>
    <name>A1S1C3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751378.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1858"/>
    <dbReference type="EnsemblBacteria" id="ABL79253">
        <property type="protein sequence ID" value="ABL79253"/>
        <property type="gene ID" value="Tpen_1858"/>
    </dbReference>
    <dbReference type="GeneID" id="4600325"/>
    <dbReference type="KEGG" id="tpe:Tpen_1858"/>
    <dbReference type="HOGENOM" id="CLU_1212650_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="24214" checksum="6B3886A8FC4BB796" modified="2007-02-06" version="1">MRRSVVALPLLLLALLTVNAVPVNPPAYTLGVSVTLGGEEVPEPVAVVLRVAFNKTLTVRFIGESNGEKVGLTVAYKVNGTERTATAGVDALNVTAAYITPIIYVFTVPQNVTVGGTTYKLSNSSTATVDPVSTDTVLFVYTAPSTAPPSGGGGNQPTAPTMPSQPSINTPSEKSRINLGELLVWVQGVLAWLMEHPEYLLLIVLALLVVLVAYYLKKRREELVIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C4</accession>
    <name>A1S1C4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751379.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1859"/>
    <dbReference type="EnsemblBacteria" id="ABL79254">
        <property type="protein sequence ID" value="ABL79254"/>
        <property type="gene ID" value="Tpen_1859"/>
    </dbReference>
    <dbReference type="GeneID" id="4600337"/>
    <dbReference type="KEGG" id="tpe:Tpen_1859"/>
    <dbReference type="HOGENOM" id="CLU_1590978_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="167" mass="18500" checksum="5D836D29E7ADA295" modified="2007-02-06" version="1">MRRLIELVKVLRKHKRVLKAGTAFAASVVALGVLWVTSPLHFLFALYVVTGLLFLAVLHGLDKTFAFLPFALMVFLITGLTGLSALLLTGSYGLHRYDLQLQIVAGSIAAVTAYLSVYWLVPRGKFEVIEGYGEQFLDEVRRVFERPPDERKVLEAKKALKAGASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E7</accession>
    <name>A1S1E7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751402.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1882"/>
    <dbReference type="EnsemblBacteria" id="ABL79277">
        <property type="protein sequence ID" value="ABL79277"/>
        <property type="gene ID" value="Tpen_1882"/>
    </dbReference>
    <dbReference type="GeneID" id="4600302"/>
    <dbReference type="KEGG" id="tpe:Tpen_1882"/>
    <dbReference type="HOGENOM" id="CLU_2839561_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="65" mass="7391" checksum="32CEEB0558983BCD" modified="2007-02-06" version="1">MRVRVERNGGRYTVYLLDSSGQIKDKFEVDEVFLDGKPAPHLVTTDVKSWMVYDLGGKTAMILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW33</accession>
    <name>A1RW33_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical 2-acetyl-1-alkylglycerophosph ocholine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751678.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0003"/>
    <dbReference type="EnsemblBacteria" id="ABL77413">
        <property type="protein sequence ID" value="ABL77413"/>
        <property type="gene ID" value="Tpen_0003"/>
    </dbReference>
    <dbReference type="GeneID" id="4600535"/>
    <dbReference type="KEGG" id="tpe:Tpen_0003"/>
    <dbReference type="eggNOG" id="arCOG01651">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_2_2"/>
    <dbReference type="OMA" id="EDCGYTN"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="33356" checksum="79D24514A7AF1347" modified="2007-02-06" version="1">MLTLLLTTVVAVVVLLLVAVAFSASRKLASPPRKVGQWSPGDMGYTYEKLEVKTSDGLTLRGWLIPRGSDRTVLVVHGYTSSKWDEWYIKPVIDILARNNFNVVAFDMRAHGESDGRYTTLGLREVEDISKIIDLLEEKGLASRLGMIGYSMGGAITLMTAAREDRVKAAVADSPYIDIRASGKRWVKRVGAPLRYLLLASYPLIIYFTSKTTRTDPSKLVMFNYASLIRKPLLIIAGRNDDLVALEEIETFFNENKKVNPNTELWVTDSKHVSAIQDYPKEYEKRVVEFFERWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW48</accession>
    <name>A1RW48_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751693.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0018"/>
    <dbReference type="EnsemblBacteria" id="ABL77428">
        <property type="protein sequence ID" value="ABL77428"/>
        <property type="gene ID" value="Tpen_0018"/>
    </dbReference>
    <dbReference type="GeneID" id="4600678"/>
    <dbReference type="KEGG" id="tpe:Tpen_0018"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_3_2"/>
    <dbReference type="OMA" id="IMECHMV"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="UniPathway" id="UPA00564">
        <property type="reaction ID" value="UER00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="170" mass="19179" checksum="239F9CE0390F53D8" modified="2007-02-06" version="1">MIIDEKDAAILELLQENARLVIKEISKRIGSPITTTHARLKRLEREGVIKAYRAILDPKKLGYDTLAYVFISFSRDRGLDQRKVAQEIAKIPEVQEVHIITGEWDILAKVRVGSVDELGDLVVNRLRNIEGVEKTYTSVVLEVVKETTKLPIRIDKANLARLPARNPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW81</accession>
    <name>A1RW81_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751726.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0051"/>
    <dbReference type="EnsemblBacteria" id="ABL77461">
        <property type="protein sequence ID" value="ABL77461"/>
        <property type="gene ID" value="Tpen_0051"/>
    </dbReference>
    <dbReference type="GeneID" id="4600611"/>
    <dbReference type="KEGG" id="tpe:Tpen_0051"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_2"/>
    <dbReference type="OMA" id="LCITRAI"/>
    <dbReference type="OrthoDB" id="66636at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="255" mass="25326" checksum="1DAE015145768A04" modified="2007-02-06" version="1">MYPLTLYALSAVSGVLVGFALGLVGGGGSILAIPLLLYFAGLSSVLDQDTAVHVAIGTTSVAVGLNALANFAMHLKSGNAELKAGAVFAGIGTVASTLGALLGRQTKGQLLLALLGVAMVLLSFWVASKRRYAGGKTSLKRLAAGSALVGFVSGFLGIGGGFLVAPALLWAGLDVKKAIGTSLLAVGLFGLSTSAVYASAGYADYAIAAAYLAGGVLGGRLGVHVSTRAPREKVALAYSALIAAVGVYTVLKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW87</accession>
    <name>A1RW87_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77467">
        <property type="protein sequence ID" value="ABL77467"/>
        <property type="gene ID" value="Tpen_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0057"/>
    <dbReference type="HOGENOM" id="CLU_3228028_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="43" mass="4864" checksum="421FAFB2710FBAC4" modified="2007-02-06" version="1">MKFGKAEREVDVKDTGKVVVAYDARSEWARRVAEGVLRELGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW92</accession>
    <name>A1RW92_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and other phosphorylases, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0062"/>
    <dbReference type="EnsemblBacteria" id="ABL77472">
        <property type="protein sequence ID" value="ABL77472"/>
        <property type="gene ID" value="Tpen_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0062"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_1_2"/>
    <dbReference type="OMA" id="CSIYVHE"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="25181" checksum="99DB8EF460CC67D6" modified="2007-02-06" version="1">MTMPYHIKAERVAGRVLVVGDPGRARLVAGMLEDARLVNENRGLLVYNGFWRGVEVSVATHGMGGAGAAIVFEELLQLGGRTLVRLGTTGAIRGEVEVGDFVVPSSAFHHPGGLFLQYFGDICVSPSPDLELAWLLASEARSAGLKVWTAPVVSSDAFYAETGEVISRWASFGAVSVEMECATLFAVTRLRGARSAAILLVNGSLVQPGKRMVSESELEERLVKGAEVALDVLAKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW94</accession>
    <name>A1RW94_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751739.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0064"/>
    <dbReference type="EnsemblBacteria" id="ABL77474">
        <property type="protein sequence ID" value="ABL77474"/>
        <property type="gene ID" value="Tpen_0064"/>
    </dbReference>
    <dbReference type="GeneID" id="4600546"/>
    <dbReference type="KEGG" id="tpe:Tpen_0064"/>
    <dbReference type="eggNOG" id="arCOG05752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084705_1_0_2"/>
    <dbReference type="OrthoDB" id="117373at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="18244" checksum="EBC9F69B73F3C164" modified="2007-02-06" version="1">MAGKGRASLFIALASILSALTAVLTYFPGLALPSPTGGYTHVGDTIIYVSALLFGPWMGLVVGLVGPVIADFLVGYPRWYVTLVAHGLQGFIAGYGAGKKFKTQLVLMVAAGLVMSFTYFVVNVYVKGLGPALVSLARDIFGQTLVSIVLASLLLKALEKAPAVKRAQELLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF2</accession>
    <name>A1RWF2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0122"/>
    <dbReference type="EnsemblBacteria" id="ABL77532">
        <property type="protein sequence ID" value="ABL77532"/>
        <property type="gene ID" value="Tpen_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0122"/>
    <dbReference type="eggNOG" id="arCOG00201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="NLHIHCG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="250" mass="26680" checksum="43299EA9606A2179" modified="2007-02-06" version="1">MHAQTVELRGVSFAYSDGEPILNNENLFLSGPGLVTILGPNGSGKTTLFKVVLGLLKPSSGSVVINGEDVTGNPVKAGKYASLVPQLSAIRRDLPLTAHELVNFVLRTRGRCKGRECEAKTMEALEAVGAAGIADKKLSEMSGGQLQRVLLARALATGADILLLDEPLSGIDPSGREYILGEIEKISKRKLVVMTTHDPVLTLNKSKTIVVFNRGVRAVGSPGDVFKLDLLRKAYGSNVLLIEKCLHVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH5</accession>
    <name>A1RWH5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751820.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0145"/>
    <dbReference type="EnsemblBacteria" id="ABL77555">
        <property type="protein sequence ID" value="ABL77555"/>
        <property type="gene ID" value="Tpen_0145"/>
    </dbReference>
    <dbReference type="GeneID" id="4600637"/>
    <dbReference type="KEGG" id="tpe:Tpen_0145"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="OrthoDB" id="41087at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="331" mass="37515" checksum="90FB755E6B6CF8F6" modified="2007-02-06" version="1">MSEDKVILKAENLKKWFTVRRGLFGGTVEVKALDGVSFELRAGEAVSLVGESGSGKTTLGKTILRLYEPTDGKLVFKGRDITHTPEKELMWYKRETGLVQQDPYGAMPSFMNIYRILEEPLIIHKVGSKEERAEMVFKALEEVRLTPVEDFAYKYPHMLSGGQLQRVAIARALILKPSLVVADEPVSMLDASVRVEILTLMRDLQEKRNISFIYITHDLSTTRYFSEWIFIMYAGHIVERAPTKTLLRNPLHPYTRALLSAIPDPDPENRKRYREVPPGEPPSLVNPPPGCRFAPRCPFATSRCRSEDPPEVEVEPGHYVKCWLFAGEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN4</accession>
    <name>A1RWN4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751879.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0204"/>
    <dbReference type="EnsemblBacteria" id="ABL77614">
        <property type="protein sequence ID" value="ABL77614"/>
        <property type="gene ID" value="Tpen_0204"/>
    </dbReference>
    <dbReference type="GeneID" id="4602215"/>
    <dbReference type="KEGG" id="tpe:Tpen_0204"/>
    <dbReference type="eggNOG" id="arCOG01522">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_2_1_2"/>
    <dbReference type="OMA" id="DGPSWLI"/>
    <dbReference type="OrthoDB" id="22033at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="435" mass="49478" checksum="D38EB45D3848BF50" modified="2007-02-06" version="1">MRRESIVVLGAGLAGLSFAYEATRLGHSVTLVEKEAEAGGLLRSEEVNGYVFDTGGSHVIFSKYPERVKFLTRILNGNIVRNRRDARIFYNGTLVKYPFENGLYALPAEKRYKALKDILERYIEYRCGGSRSVENFEEWLYATFGETIASEYLVPYNRKLWKRDLKQISLDWVGNRVPQPPLDDVIRSAVGIPTEGYLHQLFFYYPRSGGIQSLADAFKARVEGSPLSSLVLGKEAVKVDPYEGEVVLSDGSAVRGDRIVSTIPLPELYRALGLRLNLDYNSLVVVGVGVKDARLPRVHWIYFPNEDIVFHRLAILSNYSPYMSPKGSATLVAEITLRPGETFDEEKVVNATLDGLEAAGLLRGRGSVEVVRAWYWRYAYIVYDHNYSRRVREAKERLRRLGISLIGRFGLWEYMNMDDVVYRSISEARRMGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ0</accession>
    <name>A1RWQ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751895.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0220"/>
    <dbReference type="EnsemblBacteria" id="ABL77630">
        <property type="protein sequence ID" value="ABL77630"/>
        <property type="gene ID" value="Tpen_0220"/>
    </dbReference>
    <dbReference type="GeneID" id="4601813"/>
    <dbReference type="KEGG" id="tpe:Tpen_0220"/>
    <dbReference type="eggNOG" id="arCOG03229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102155_0_0_2"/>
    <dbReference type="OMA" id="FVANHYK"/>
    <dbReference type="OrthoDB" id="98943at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007368">
        <property type="entry name" value="DUF434"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041652">
        <property type="entry name" value="DUF5616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04256">
        <property type="entry name" value="DUF434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18481">
        <property type="entry name" value="DUF5616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF434" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5616" evidence="2">
        <location>
            <begin position="79"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="244" mass="26593" checksum="F03D98F920B54C0D" modified="2007-02-06" version="1">MKGSEATAGYTRITLNSDFICEAAKDFFYLVNRGYSRKQSLELVTARYGLSKVEKLALYRSIFPREVAASRRKRLAELESLGTGLLVVDAFNQVGTVSSALLGDVLVVGNDGIVRDLAAGYRRISFSPLYVSALYVLLSYLSRLGVERAVFVFDSQVSFSARFAGILKSFASLLGHECWSIISPNADNTVIQLSEWEGAAVATSDSVILEKTKAPVVDVAKNIVSRVSLETVVDLGECLDDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR0</accession>
    <name>A1RWR0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3</name>
        <name evidence="7" type="ordered locus">Tpen_0230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751905.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0230"/>
    <dbReference type="EnsemblBacteria" id="ABL77640">
        <property type="protein sequence ID" value="ABL77640"/>
        <property type="gene ID" value="Tpen_0230"/>
    </dbReference>
    <dbReference type="GeneID" id="4601220"/>
    <dbReference type="KEGG" id="tpe:Tpen_0230"/>
    <dbReference type="eggNOG" id="arCOG04070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="OrthoDB" id="31722at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_A">
        <property type="entry name" value="Ribosomal_L3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="334" mass="37794" checksum="5A550D0B51D808FB" modified="2007-02-06" version="1">MAKGHRPRRGSRAYYPRKRARSIVARVRRWPQNREGFLGFAGYKVGMLHVIGVEMNKNSPFYGQERFYAATVIEVPPLKVVAVRVYEKTPYGKKTLCEVWAKDLPKDLERVFPLPKDQSYHEEQLKKLEEVKSRVSEVRVLAATQPRLSGLGKKKPELIEIAVGGPPEKALSLALEKLGKDLTISDVFKEGDYIDVIAVTKGKGFQGSVKRFGVEEMPRWHKHRKGHSRIGSVGPQKPAIMFYTPFPGQLGFHQRTEYNKRILKVGDAESLKEINPPGGWPHYGLVRSQFIIVEGSVPGAVKRLVRLRHAIRALRVLPPPQITYISTAPWPPAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW1</accession>
    <name>RS12_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps12</name>
        <name type="ordered locus">Tpen_0281</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751956.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWW1"/>
    <dbReference type="SMR" id="A1RWW1"/>
    <dbReference type="STRING" id="368408.Tpen_0281"/>
    <dbReference type="EnsemblBacteria" id="ABL77691">
        <property type="protein sequence ID" value="ABL77691"/>
        <property type="gene ID" value="Tpen_0281"/>
    </dbReference>
    <dbReference type="GeneID" id="4602091"/>
    <dbReference type="KEGG" id="tpe:Tpen_0281"/>
    <dbReference type="eggNOG" id="arCOG04255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_2"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="85293at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000296056" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <sequence length="147" mass="16464" checksum="F4E38619591E5D79" modified="2007-02-06" version="1">MPGSKSPRGMFAARKLELKRKKFRWSDLEYKRRILQLKKKVDPLEGAPQARGIVVEKVGIESRQPNSAVRKCVRVQLLKNGKVVTAFLPGDGALLFVNEHDEVVIEGIGGPEGRAYGDLPGVRWKVIKVNGVSLKEILRGRKQKPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX8</accession>
    <name>A1RWX8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0298"/>
    <dbReference type="EnsemblBacteria" id="ABL77708">
        <property type="protein sequence ID" value="ABL77708"/>
        <property type="gene ID" value="Tpen_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0298"/>
    <dbReference type="eggNOG" id="arCOG15272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="OMA" id="WIRNMLY"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="44"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="411"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="835" mass="96344" checksum="D0F13C85930F579E" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ0</accession>
    <name>A1RWZ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751985.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0311"/>
    <dbReference type="EnsemblBacteria" id="ABL77720">
        <property type="protein sequence ID" value="ABL77720"/>
        <property type="gene ID" value="Tpen_0311"/>
    </dbReference>
    <dbReference type="GeneID" id="4602079"/>
    <dbReference type="KEGG" id="tpe:Tpen_0311"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OMA" id="SSPRYMI"/>
    <dbReference type="OrthoDB" id="109463at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="87"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="193" mass="22182" checksum="0E4C8A33FC9B24BE" modified="2007-02-06" version="1">MEKGQEVAKISGEGVFDGRIVRVLDKEFAEQLYQRGYGMLSGEILELTLVEAAYLVYREMLKVKDDQGRTLSFPEIVRLASNFDPDFWVKLNVYTDLRNRALPAKPGVNPYEFLVDWKKKGKPRRLLVRILREGTRVSFPEFEDMFRRALESDRELVIAIVDKEGVVTYYTVEGGSYEQVGASVEDNFEVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX15</accession>
    <name>A1RX15_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752010.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0336"/>
    <dbReference type="EnsemblBacteria" id="ABL77745">
        <property type="protein sequence ID" value="ABL77745"/>
        <property type="gene ID" value="Tpen_0336"/>
    </dbReference>
    <dbReference type="GeneID" id="4601703"/>
    <dbReference type="KEGG" id="tpe:Tpen_0336"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="ASHTGKL"/>
    <dbReference type="OrthoDB" id="15044at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="508" mass="55161" checksum="498581F86E2118DF" modified="2007-02-06" version="1">MTSESLKPFFDPRGVVVVGASREEEKPGHVIFRVLLENRKKGLLKAPVYGVNPKADYILGEKVFPSVKDIPGEVDLAVIVIPAEHVKRAIEDLGVKGIKAAIIISAGFSEIGRSDLEREVAETAKKHGIRIIGPNCIGVYSPWSGVDTIFLPYTKVLEDGREVLNAPRPSKGFVALISQSGAVGTAALDYMYGEGIGLSHFVSIGNKADVDEVELVEYLGGDDRTRVILLYLENIKRGREFIEVAGKVTLKKPVVVLKAGRTSAGRRAAASHTAALAGVDEVYDAAFRRSGVIRANDIEELFDYAKALAMQPPARGERIGIITDGGGAGVMATDIAEMLGLKVPELQGNARRELEELRERGIFPRYAQLSNPVDLTGSATSEMFVEATRILLESDEVDAVVVLALHQVPGIPDPVKLAREISRLAAGYAKPVVAVDTGWSEAAILERKEFDSMGVPSYPTPERAVKSLSALVRYGKYLSSRGALGRYLQEYLDFKRKNILQMHKNNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX19</accession>
    <name>A1RX19_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752014.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0340"/>
    <dbReference type="EnsemblBacteria" id="ABL77749">
        <property type="protein sequence ID" value="ABL77749"/>
        <property type="gene ID" value="Tpen_0340"/>
    </dbReference>
    <dbReference type="GeneID" id="4601707"/>
    <dbReference type="KEGG" id="tpe:Tpen_0340"/>
    <dbReference type="eggNOG" id="arCOG04101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363712_0_0_2"/>
    <dbReference type="OMA" id="ITHVLVS"/>
    <dbReference type="OrthoDB" id="94516at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="200" mass="23170" checksum="98B99825DD452AD5" modified="2007-02-06" version="1">MALQELAFLPASRGTLQYLRRKLDLVKRGKNVLQMRRDQLAKELLAIMDELKKRPEAEKQFIEAARTAALMRMSRGEYEFRSMSSLVKPPKITHVLVSYQGVPVPQARVQEEPDWSKLLDPDYRRVVETLWNAVKTMIDVANKEVAVEKISDQLLYINRVVNSLEKNVIPQLESALRRVEERVVDEELEDFVRVKLLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX52</accession>
    <name>A1RX52_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752047.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0373"/>
    <dbReference type="EnsemblBacteria" id="ABL77782">
        <property type="protein sequence ID" value="ABL77782"/>
        <property type="gene ID" value="Tpen_0373"/>
    </dbReference>
    <dbReference type="GeneID" id="4600773"/>
    <dbReference type="KEGG" id="tpe:Tpen_0373"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080079_0_0_2"/>
    <dbReference type="OMA" id="SEFRQEQ"/>
    <dbReference type="OrthoDB" id="80752at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="PTHR31027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMF_TATA_bd" evidence="2">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="318" mass="37904" checksum="1961FD46B71F719B" modified="2007-02-06" version="1">MAAETESIESLRQQLIEYRQKLQEISAKIQEARSKRDSANGEVKRISAEIRSLREQYQALRQQIAAVAEQKKTLYEKISKLREEKKGILEQLNKLRDELKRLNAEYNNLRGFLGSKRYDEDELRNRIEQLEWQYQTMTLPPEVEKVLVNKIRSLESIYVNVKHLNEVRAKIEEIRAQIPELKKKVQAINEELKTVVSEYLKVKEQMQALKQQRDELVKRLVELKQERDRIRETANNYHQIYISLLSEEKSLREELERISILLKAKELSQHLEERKRQLYGKAMEAYERFRRGDPVTLDEWKLLVEFNLINLKSGEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA1</accession>
    <name>A1RXA1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="5" type="ordered locus">Tpen_0422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752096.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0422"/>
    <dbReference type="EnsemblBacteria" id="ABL77831">
        <property type="protein sequence ID" value="ABL77831"/>
        <property type="gene ID" value="Tpen_0422"/>
    </dbReference>
    <dbReference type="GeneID" id="4602101"/>
    <dbReference type="KEGG" id="tpe:Tpen_0422"/>
    <dbReference type="eggNOG" id="arCOG01946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109671_1_1_2"/>
    <dbReference type="OMA" id="DGFPMRP"/>
    <dbReference type="OrthoDB" id="112720at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_S6e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="131" mass="14240" checksum="BA81200FB455B148" modified="2007-02-06" version="1">MSSKVSFKVVISDPKTGKAEQVEVSGEQALRLIGLKIGDIIDGGLVGKPGVKLQIRGGSGRAGEPMRPDIEGARKGYFLLSGPPGYWPREKGERRRRFVRGNVISDDIVQINTVIVYDEEKAQQATPHARG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA6</accession>
    <name>DNLI1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase 1</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [ATP] 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lig1</name>
        <name type="ordered locus">Tpen_0427</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXA6"/>
    <dbReference type="SMR" id="A1RXA6"/>
    <dbReference type="STRING" id="368408.Tpen_0427"/>
    <dbReference type="EnsemblBacteria" id="ABL77836">
        <property type="protein sequence ID" value="ABL77836"/>
        <property type="gene ID" value="Tpen_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0427"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_1_2"/>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000365265" description="DNA ligase 1">
        <location>
            <begin position="1"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <sequence length="531" mass="60518" checksum="2D5E122C73504389" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB1</accession>
    <name>A1RXB1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0432"/>
    <dbReference type="EnsemblBacteria" id="ABL77841">
        <property type="protein sequence ID" value="ABL77841"/>
        <property type="gene ID" value="Tpen_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0432"/>
    <dbReference type="HOGENOM" id="CLU_2257508_0_0_2"/>
    <dbReference type="OrthoDB" id="130721at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="103" mass="11636" checksum="EA1F2C15D96B46E4" modified="2007-02-06" version="1">MHIAERKAFSESWDVISSGGDTLKEGFVLFVDEGEASKKILEELKSDGRWTENLKIIDISKSKLRGWLLLEYGSVKTPMLVTGSNVISGYEEVLSFLRKLVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC0</accession>
    <name>A1RXC0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ordered locus">Tpen_0441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0441"/>
    <dbReference type="EnsemblBacteria" id="ABL77850">
        <property type="protein sequence ID" value="ABL77850"/>
        <property type="gene ID" value="Tpen_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0441"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_3_2"/>
    <dbReference type="OMA" id="FMCGACD"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023248934" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023248935" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="138" mass="15351" checksum="D83090EA53BFB283" modified="2007-02-06" version="1">MGLGGVGRHLIVEMFECDGRLLDSLEVVKSALLDAAVASNSTVVGFDFYRFKPHGISGYVLVAESHISIHTWPEYGYAAVDVFTCGEHTDPWKGLEILKERLRAKKVTIISIERGVGIENYAGYWTPTREKEQAVQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD3</accession>
    <name>A1RXD3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NMD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0454"/>
    <dbReference type="EnsemblBacteria" id="ABL77863">
        <property type="protein sequence ID" value="ABL77863"/>
        <property type="gene ID" value="Tpen_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0454"/>
    <dbReference type="eggNOG" id="arCOG04149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065087_0_0_2"/>
    <dbReference type="OMA" id="CHMCGSY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="349" mass="39779" checksum="848C56E4AEEF883D" modified="2007-02-06" version="1">MKILCPVCGKPTDRLIDGLCPECYRRSRRIMEPKRDALRVKVCRKCGRLYYKDEWLSSSEELAMSVEKDLPRLVKVRGELRSARVSLYIDKGFAEVHAVGRADSGIDFFYEETLRIPLKTEYSICDWCLGKVSKKKSAIVQVRASERELSNDEKKAVYKVLDELSSSGNAEALPWDVKEEAGGLDLYFSSPRAAREVVRRLSERVYFEVLETSKKVGVDGSGHEKYQSTIRLLLPHIARGDVVLYRNEYFLVKDVDPKRVTLLNLSSYEKEVYMLNKSLLSRISVIARANELKMGVVVYTAGDKVHVMSNDYKVYEVDIPPSARKLFQEEQTVGLLVLENKVLLIPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE5</accession>
    <name>A1RXE5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752140.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77875">
        <property type="protein sequence ID" value="ABL77875"/>
        <property type="gene ID" value="Tpen_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="4600994"/>
    <dbReference type="KEGG" id="tpe:Tpen_0466"/>
    <dbReference type="eggNOG" id="arCOG01680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_2"/>
    <dbReference type="OMA" id="EGLKCYY"/>
    <dbReference type="OrthoDB" id="128954at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="108" mass="12499" checksum="4E4865D5049494B9" modified="2007-02-06" version="1">MSSEDAQLFEAQAEFCKSLCHPLRLKIISLLYAGPRNVSEIVNSLGEPQPVVSRHLALLREKGVVRAERRGTNVYYYLAYPELEEACRIVRRVIRKMIEERAQALQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE9</accession>
    <name>A1RXE9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ordered locus">Tpen_0470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752144.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0470"/>
    <dbReference type="EnsemblBacteria" id="ABL77879">
        <property type="protein sequence ID" value="ABL77879"/>
        <property type="gene ID" value="Tpen_0470"/>
    </dbReference>
    <dbReference type="GeneID" id="4602029"/>
    <dbReference type="KEGG" id="tpe:Tpen_0470"/>
    <dbReference type="eggNOG" id="arCOG01344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OMA" id="YIDGPVG"/>
    <dbReference type="OrthoDB" id="92409at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="163" mass="18410" checksum="B713A056BF860329" modified="2007-02-06" version="1">MVNAKFVPPRLLIEELAAYLKENVKEIQPPEWALYAKTGPTRERPPQDPDWWYKRCAALLRKIYLEGPVGLERLRTAYGGRTKNTVKRKHFKKAGGSAIRKALQQLESAGLVAKTPRGRVITEKGRALVDTTALRIFKKLVEERPELSKYLAKPASTPVSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG1</accession>
    <name>A1RXG1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752156.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0482"/>
    <dbReference type="EnsemblBacteria" id="ABL77891">
        <property type="protein sequence ID" value="ABL77891"/>
        <property type="gene ID" value="Tpen_0482"/>
    </dbReference>
    <dbReference type="GeneID" id="4601877"/>
    <dbReference type="KEGG" id="tpe:Tpen_0482"/>
    <dbReference type="eggNOG" id="arCOG03727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1207669_0_0_2"/>
    <dbReference type="OMA" id="WHRASTE"/>
    <dbReference type="OrthoDB" id="122845at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="25217" checksum="B815A1648CA179A6" modified="2007-02-06" version="1">MISFKVELVLKKAAELLSRGKVASITEIVSETGLPQEFVQLVLESLEIPVVNGYIEESLPGVLVKAWLHGYDVVSLALSSGWSSFEELCCYLAESFGLRTKRNLRFKNLGRRFEVDLIAASDNLVLVVDCKRWRRAPPSSLKKAAKAHLERCLALADKMKSGADIGIRLGKQAKLYPLIVNLYDVGPLVEEGVLILGLKEFKEILQSLDPLLLEEMGAKSITVTTPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL5</accession>
    <name>A1RXL5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0539"/>
    <dbReference type="EnsemblBacteria" id="ABL77945">
        <property type="protein sequence ID" value="ABL77945"/>
        <property type="gene ID" value="Tpen_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0539"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="444" mass="49080" checksum="A370E94E21ABF5FD" modified="2007-02-06" version="1">MNGPKIIVEPPGPNSRKIAEKDSALLMQSFARWYPLVAKRAHGVWVEDVDGNVYLDFNSGIGVTNTGHCHPKVVKAIKEQAERLLHYSLTDFLYEEPVKLAEKLVSITPGRFPKKVFYTNSGTESIEAAIKTARGHFRGTRPYIIAFAGSFHGRTYGSLSLTSSKPVQRRHLGPLLPGVFHAPYPYCYRCPFRQKYPECNLWCVDFIEEWMLKKYVPPEEVAAFVVEPIAGEGGYIVPPPEFFKRLRELADKYGILLVVDEVQSGFGRTGKWFAIEHFGVEPDIIAVAKGIASGLPLGAIIGRAEVMDLPPGSHASTFGGNPVSCAAALATIEVIEEEKLLDNATRVGEYAMKRLRELQEEIPYIGDVRGKGLMIGVELIARDGSPNPKLLQKTLEIAFKKGLLVIGAGVSTIRIAPPLIITQQEMETGLRILEESLREALKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM1</accession>
    <name>A1RXM1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase, TrmH family, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752216.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0545"/>
    <dbReference type="EnsemblBacteria" id="ABL77951">
        <property type="protein sequence ID" value="ABL77951"/>
        <property type="gene ID" value="Tpen_0545"/>
    </dbReference>
    <dbReference type="GeneID" id="4600502"/>
    <dbReference type="KEGG" id="tpe:Tpen_0545"/>
    <dbReference type="eggNOG" id="arCOG01018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_0_1_2"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="OrthoDB" id="93855at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="28809" checksum="2119A57558320641" modified="2007-02-06" version="1">MGAHREAPCERLAKEVSVAFVEPLYEQNIGYIARSMKNFCLAKLYLVKPRCSVGLESRRYAMHAADIVENAVIVGSLGELVGMHDLVACTTGVKGKPPLRRYVSPGEMASLFAESTGSKLVVIGREDWGLSAEELSICDMLVTIEANPEYPSLNASHAAAIVFYELFNKYHSVQQSLERPPREEVEAFLKHLGDLTTLLGYDETRSERLLLSIKRLLAETRFSKTDLRILFGLVRDSLETIKRTHRESARITHKQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS4</accession>
    <name>A1RXS4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752269.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0599"/>
    <dbReference type="EnsemblBacteria" id="ABL78004">
        <property type="protein sequence ID" value="ABL78004"/>
        <property type="gene ID" value="Tpen_0599"/>
    </dbReference>
    <dbReference type="GeneID" id="4601239"/>
    <dbReference type="KEGG" id="tpe:Tpen_0599"/>
    <dbReference type="eggNOG" id="arCOG00924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="TGDMAME"/>
    <dbReference type="OrthoDB" id="55756at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="238" mass="26076" checksum="D7B219095C9625E8" modified="2007-02-06" version="1">MPLLAVDSLSVGYNGMEVVSNVSFTLDKGEFLAVVGPNGSGKSTLLKGLFGLADVLGGKVLFDGRDITRLAPHKRSLMGMGYLPQTGNVFEELTGRENLVLAGYDLPREDFERRLEEVLDFLPEVRGFLNRKATTLSGGERQMLALAMQLVRKPSLIMFDEPSAALAPKVVEHVFERIRMLNKGLGITVILVEQDTRRALKIAEKALLLVSGRTRFYGDAGELLARKDLVALYLGIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS6</accession>
    <name>A1RXS6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0601"/>
    <dbReference type="EnsemblBacteria" id="ABL78006">
        <property type="protein sequence ID" value="ABL78006"/>
        <property type="gene ID" value="Tpen_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0601"/>
    <dbReference type="eggNOG" id="arCOG01273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_0_2"/>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="349" mass="37525" checksum="02FB68A1552A676E" modified="2007-02-06" version="1">MDPLMFLVDLGVLYSVYVILASSLNLEYGELGLPNFAKSAFFAVGAFSVGALSVRLGTLLLGITMEGEFKLKSVYYATLVSQALVNSPQLGVILFVVPLMIAVPLAALLGVLASYPALRLREDYLGMLLIAFSEIIRVVARNYEPLVGGTYGAGVVDFLAWIPPPLKQVVLLALSSSIAFAIWLAYYRLSRSPFGRVLRAIRDNELAASVLGRDVAKMRMTVMALGSGMAAVAGVLYAFYVGSVNPDDFTISKTFLVALMVIIGGRGNPYGALVGPATYIAVDRSIQFVKQYLALPFDPNYASYVILGVALILIVMKKPEGIAPEKPAITLPSALRRALSPRHTVPKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW3</accession>
    <name>A1RXW3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Tpen_0640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752308.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0640"/>
    <dbReference type="CAZy" id="GT66">
        <property type="family name" value="Glycosyltransferase Family 66"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78043">
        <property type="protein sequence ID" value="ABL78043"/>
        <property type="gene ID" value="Tpen_0640"/>
    </dbReference>
    <dbReference type="GeneID" id="4601437"/>
    <dbReference type="KEGG" id="tpe:Tpen_0640"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361188_0_0_2"/>
    <dbReference type="OMA" id="VAYSSWY"/>
    <dbReference type="OrthoDB" id="45041at2157"/>
    <dbReference type="BRENDA" id="2.4.99.18">
        <property type="organism ID" value="11662"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABL78043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="731" mass="82067" checksum="94B8381C342837EB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW6</accession>
    <name>A1RXW6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="4" type="ordered locus">Tpen_0644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752311.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0644"/>
    <dbReference type="EnsemblBacteria" id="ABL78046">
        <property type="protein sequence ID" value="ABL78046"/>
        <property type="gene ID" value="Tpen_0644"/>
    </dbReference>
    <dbReference type="GeneID" id="4601510"/>
    <dbReference type="KEGG" id="tpe:Tpen_0644"/>
    <dbReference type="eggNOG" id="arCOG04109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_2"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="106603at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="95" mass="11275" checksum="D8CD22620271DD60" modified="2007-02-06" version="1">MKVPSVIRTYCPRCKTYTEHEVTLYKAGKRRTLAEGQRRYLRKQKGYGSKRKPEQKRTAKVTKKQVLKLKCKVCGYTYHKEGIRLKKLEIVEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX5</accession>
    <name>A1RXX5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="4" type="ordered locus">Tpen_0653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752320.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0653"/>
    <dbReference type="EnsemblBacteria" id="ABL78055">
        <property type="protein sequence ID" value="ABL78055"/>
        <property type="gene ID" value="Tpen_0653"/>
    </dbReference>
    <dbReference type="GeneID" id="4601611"/>
    <dbReference type="KEGG" id="tpe:Tpen_0653"/>
    <dbReference type="eggNOG" id="arCOG04186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="OMA" id="GQNAYTK"/>
    <dbReference type="OrthoDB" id="96138at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="207" mass="23439" checksum="C15971B0850FAA9B" modified="2007-02-06" version="1">MSARAKTKDKWSMKKWIKVLAPKAFGFANLGLIPADEPEKALGRTVEVSFYDITKDVSQLHIKLKFQIVKVDDGIALTQLKLMEMTRDYIRSLVRRGTSRVDAILDVQTKDGVKMRVMALAVTVSRIKTSQKKAIRRIMFDIISEKAASLDFDTFIQQAVIGTMATEMQMQAKKIYPIKKVEVYKIKVLTPTTEIPLALPEQVLAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY4</accession>
    <name>A1RXY4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HVO_2753_ZBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0662"/>
    <dbReference type="EnsemblBacteria" id="ABL78064">
        <property type="protein sequence ID" value="ABL78064"/>
        <property type="gene ID" value="Tpen_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0662"/>
    <dbReference type="eggNOG" id="arCOG01989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="OMA" id="KCGFEGP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="PTHR40733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="59" mass="6586" checksum="250BC3FDC5C8A2BC" modified="2007-02-06" version="1">MSRVMLLPKCTSCGRPIAPYEKAVSFRCPNCGEAVIWRCSKCRKQGNKYVCPKCGFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ6</accession>
    <name>A1RXZ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0674"/>
    <dbReference type="EnsemblBacteria" id="ABL78076">
        <property type="protein sequence ID" value="ABL78076"/>
        <property type="gene ID" value="Tpen_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0674"/>
    <dbReference type="HOGENOM" id="CLU_2490632_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="86" mass="8887" checksum="E0A72CD34A499C97" modified="2007-02-06" version="1">MRAVEESIFTFFELLLLVGILTYASATAPGENSLALVYGISQALPEGSCAVIMSASPLSLGNATLGKSVAVCKVGNETVVKPWPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY01</accession>
    <name>A1RY01_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="5">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752346.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0679"/>
    <dbReference type="EnsemblBacteria" id="ABL78081">
        <property type="protein sequence ID" value="ABL78081"/>
        <property type="gene ID" value="Tpen_0679"/>
    </dbReference>
    <dbReference type="GeneID" id="4601879"/>
    <dbReference type="KEGG" id="tpe:Tpen_0679"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_2"/>
    <dbReference type="OMA" id="ENFRFAQ"/>
    <dbReference type="OrthoDB" id="2808at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="486"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="718" mass="79900" checksum="B412160A24FC220C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY39</accession>
    <name>A1RY39_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752384.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0717"/>
    <dbReference type="EnsemblBacteria" id="ABL78119">
        <property type="protein sequence ID" value="ABL78119"/>
        <property type="gene ID" value="Tpen_0717"/>
    </dbReference>
    <dbReference type="GeneID" id="4601481"/>
    <dbReference type="KEGG" id="tpe:Tpen_0717"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_2"/>
    <dbReference type="OMA" id="VDHTYLF"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="343" mass="37802" checksum="B7626DFE76181168" modified="2007-02-06" version="1">MGVNVAVVGVGRWGRNHVRVLSSLRGSLVGRIVVVDADEARASSVAKQFAVDAYYSSVEELVKDEKDLDAAVVAVPTVYHFEVASKLLNYADVLVEKPLAATLDEGYRLVELSRKLGRRLAVGHIERFNPVVGAAYAAVRGKEILSMESKRLGPGPAREYTLNLGVAHDLLVHDVDVVNMFLGEPPGRVFAYKIDGGDFPFEVEVTALYEYSQRRIATLSASWRTVPSYKHRSLTIRLPDSVIRVDYILRRIVVDRGVQELPRDSLRVPVFAEESYVEVSYLQEEPLKAELIDFLEAVKLGGKPRVDGLAGYVALKCVVKALESASKGVPVPIGWDEIEKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY44</accession>
    <name>A1RY44_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752389.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0722"/>
    <dbReference type="EnsemblBacteria" id="ABL78124">
        <property type="protein sequence ID" value="ABL78124"/>
        <property type="gene ID" value="Tpen_0722"/>
    </dbReference>
    <dbReference type="GeneID" id="4601487"/>
    <dbReference type="KEGG" id="tpe:Tpen_0722"/>
    <dbReference type="HOGENOM" id="CLU_332525_0_0_2"/>
    <dbReference type="OrthoDB" id="133689at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="865" mass="95396" checksum="01A5003B4701798C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY60</accession>
    <name>A1RY60_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752405.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0738"/>
    <dbReference type="EnsemblBacteria" id="ABL78140">
        <property type="protein sequence ID" value="ABL78140"/>
        <property type="gene ID" value="Tpen_0738"/>
    </dbReference>
    <dbReference type="GeneID" id="4601145"/>
    <dbReference type="KEGG" id="tpe:Tpen_0738"/>
    <dbReference type="eggNOG" id="arCOG04219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027052_1_0_2"/>
    <dbReference type="OMA" id="IDPGTTT"/>
    <dbReference type="OrthoDB" id="9617at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707">
        <property type="entry name" value="PTHR40707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="662" mass="73156" checksum="098F54F4A0636EDE" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY69</accession>
    <name>A1RY69_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752414.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0747"/>
    <dbReference type="EnsemblBacteria" id="ABL78149">
        <property type="protein sequence ID" value="ABL78149"/>
        <property type="gene ID" value="Tpen_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="4600398"/>
    <dbReference type="KEGG" id="tpe:Tpen_0747"/>
    <dbReference type="eggNOG" id="arCOG04290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_1_0_2"/>
    <dbReference type="OMA" id="CGQIYWP"/>
    <dbReference type="OrthoDB" id="96038at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="192" mass="21424" checksum="4A9A86ED89EBAE72" modified="2007-02-06" version="1">MAFPGLRPVAATAKFFRTDAATPGGCTLEYREVVADGMLGKLAKWLRILGVRALYVRGAPDSDVEELLSRLEDPVFLTRDRALYARLASKGFKAVLVPEAPAEAQLAFVLPRLGVEPVLDMSRTLCPLCGSSLKRVDVREVEGLVPEGVLSAYDEFYRCTGCGQVYWRGTHFYEMKRKLEKVWWLIHGKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE0</accession>
    <name>A1RYE0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0819"/>
    <dbReference type="EnsemblBacteria" id="ABL78220">
        <property type="protein sequence ID" value="ABL78220"/>
        <property type="gene ID" value="Tpen_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0819"/>
    <dbReference type="eggNOG" id="arCOG00500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_3_2_2"/>
    <dbReference type="OMA" id="HECNGAD"/>
    <dbReference type="OrthoDB" id="107971at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="256" mass="28005" checksum="B79AEE804A6336B5" modified="2007-02-06" version="1">MKLSGGEKLARVIFLGTAGSTFSGRNMPPSLLVDGGVLLDCPAACPYVLATMGRLDEVRIILLSHLHPDHSLGVVELLWHLWIRGSGKRVEVVGPRGTRRFFERMLEVLHPEKFETILSHGVFREIGPGDTVGNAKAFEALHTVEALAYRLTVSDRSLCYSGDTSPSEKLVEGFAGCDLLVHEATYPPGMEDAALRDGHSTPVHAATIALRAGARRLALVHLPYARLGDVDEEYLRAARAIFKNTFIPKPFEEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG4</accession>
    <name>A1RYG4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_0843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752509.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0843"/>
    <dbReference type="EnsemblBacteria" id="ABL78244">
        <property type="protein sequence ID" value="ABL78244"/>
        <property type="gene ID" value="Tpen_0843"/>
    </dbReference>
    <dbReference type="GeneID" id="4600777"/>
    <dbReference type="KEGG" id="tpe:Tpen_0843"/>
    <dbReference type="eggNOG" id="arCOG01352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OMA" id="WLQNRNG"/>
    <dbReference type="OrthoDB" id="40988at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="188"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="419" mass="46357" checksum="D8C4172EDCCDC5D6" modified="2007-02-06" version="1">MTYENDPVYQMAVKQLTESAKILNLPEDVVEVLKHPERLLHVKIPVKLDNGRIAVFHGWRSQHNSALGPYKGGIRYHPNVTEGEVVALSMWMTWKNALAGIPYGGGKGGVKVNPKELSPRELEELSRKYFAAISRIVGEDIDIPAPDVYTNPQTMAWYMDEYSKIVGYNAWGVVTAKPKEIGGLYARIVSTGLGTAIAAREAAKRVLDGVENKTVAVQGFGNVGMYAAKYLSEWGAKVVAVTDSKGGVYNPAGLNVEELIKVKEETGAVANYKDYKKTITNEEILELDVDILIPAAVENVITKDNAPRVKAKIISEGANGPTTPEADEILRKKGAVVVPDILANAGGVVMSWIEWANNRMGNWLTEEEALARLEKKMVENFNTVYNEWQKRFHEYPMRVAAYAIAVERVVTAMKLRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH1</accession>
    <name>A1RYH1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Tpen_0850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752516.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0850"/>
    <dbReference type="EnsemblBacteria" id="ABL78251">
        <property type="protein sequence ID" value="ABL78251"/>
        <property type="gene ID" value="Tpen_0850"/>
    </dbReference>
    <dbReference type="GeneID" id="4601975"/>
    <dbReference type="KEGG" id="tpe:Tpen_0850"/>
    <dbReference type="eggNOG" id="arCOG00359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_2"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="OrthoDB" id="27688at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="695" mass="75420" checksum="CEDF83805CFA709D" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI3</accession>
    <name>A1RYI3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752528.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0862"/>
    <dbReference type="EnsemblBacteria" id="ABL78263">
        <property type="protein sequence ID" value="ABL78263"/>
        <property type="gene ID" value="Tpen_0862"/>
    </dbReference>
    <dbReference type="GeneID" id="4602205"/>
    <dbReference type="KEGG" id="tpe:Tpen_0862"/>
    <dbReference type="eggNOG" id="arCOG04081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_2"/>
    <dbReference type="OMA" id="YDMGAKM"/>
    <dbReference type="OrthoDB" id="17080at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="54"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="441" mass="49253" checksum="8DEED02D1A466EA5" modified="2007-02-06" version="1">MMKSGERIGVHSHIKGLGIRNNEPLPVADGLVGQIEARRAAWLVVQLIKAGKMAGRAILLVGPPGTGKTAIAVAIARELGPETPFMALSGSEIYSAELKKTEVLMQALRKSIGVRIRERRWIYEGVVDKVDYKFDRHPLNPYVQVPVGGTITLRTEKETRSLRVDSNIVYQLLQKGVEEGDVIWIDEETGRVTRVGRAKGAANYDVGVRELVDVPSGPVYKEKEFVYTLTLHQLDEMHARSESLLSLIFGAPEYREIPPDVRAKVDKTVKEWVDSGRAELIPGVLFIDDAHMLDIEAFSFLSRAMESELSPIIILATNRGFTKIRGTDVEAPHGMPLDLLDRLLIIKTKPYTADEIREILKIRAKEEGVTLDEQALEELVRLGTERSLRYAAHLLAPAKILAEQRGKSSVGVEEVREVSTLFISTRESAQYLKEFEEKMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI7</accession>
    <name>A1RYI7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752532.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0866"/>
    <dbReference type="EnsemblBacteria" id="ABL78267">
        <property type="protein sequence ID" value="ABL78267"/>
        <property type="gene ID" value="Tpen_0866"/>
    </dbReference>
    <dbReference type="GeneID" id="4602209"/>
    <dbReference type="KEGG" id="tpe:Tpen_0866"/>
    <dbReference type="eggNOG" id="arCOG00919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870843_0_0_2"/>
    <dbReference type="OrthoDB" id="109199at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="131" mass="15265" checksum="9F448045A9C0F88A" modified="2007-02-06" version="1">MSREVVSRRQKAFNVERRLVKMLSSNRENYVFRVPVSGVGENFPDVFLVNNVEDRVVAFEVKTTVNSKVKVKAHQVSKLFRFLEAFKKYKTREAVIAVWFSSEGKWVFRRVDGLFASDIVITSEDESDWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ7</accession>
    <name>A1RYJ7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752542.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0876"/>
    <dbReference type="EnsemblBacteria" id="ABL78277">
        <property type="protein sequence ID" value="ABL78277"/>
        <property type="gene ID" value="Tpen_0876"/>
    </dbReference>
    <dbReference type="GeneID" id="4600358"/>
    <dbReference type="KEGG" id="tpe:Tpen_0876"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_2"/>
    <dbReference type="OMA" id="LRMIIDP"/>
    <dbReference type="OrthoDB" id="113911at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="102" mass="11634" checksum="20F97EC57EBBB1B1" modified="2007-02-06" version="1">MAGEVTQERVMEALKEVYDPEIPFNVVDLGLVYGVEVDGRKVKVKMTLTAIGCPMSYFLVEMVRDVIKEKIPEVEDVEVDLVFDPPWTPDRIKPEVRRLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK0</accession>
    <name>A1RYK0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A24A, prepilin type IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0879"/>
    <dbReference type="EnsemblBacteria" id="ABL78280">
        <property type="protein sequence ID" value="ABL78280"/>
        <property type="gene ID" value="Tpen_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0879"/>
    <dbReference type="eggNOG" id="arCOG02298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286409_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="227" mass="24898" checksum="016846F6B0EBE5BB" modified="2007-02-06" version="1">MCFHDAISLLRSLVVAGTLWVAAYQDFRTREIDDKVWIAGTLLATPLLAAELASGRIVLQLYLLSLAVSLALAVLSLKLGLTGEADAIAFAFLGFFEPPRLSPLFAVPLGTILLLSLVPTAFFAAYNVYWNLGKPQKFEGYRLNTLERLVALVAMRYVSREEYERYSYMLAPATRVDADGLKIEIGVGIPGRAEPPSLPGFWATALAPYVTFIALGYSAYLALCWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM8</accession>
    <name>A1RYM8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752573.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0907"/>
    <dbReference type="EnsemblBacteria" id="ABL78308">
        <property type="protein sequence ID" value="ABL78308"/>
        <property type="gene ID" value="Tpen_0907"/>
    </dbReference>
    <dbReference type="GeneID" id="4602120"/>
    <dbReference type="KEGG" id="tpe:Tpen_0907"/>
    <dbReference type="eggNOG" id="arCOG01806">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103221_0_0_2"/>
    <dbReference type="OMA" id="KENMASI"/>
    <dbReference type="OrthoDB" id="70125at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016619">
        <property type="entry name" value="UCP014439_ACT"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014439">
        <property type="entry name" value="APE1894_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="24505" checksum="8CF3AE8C284F190A" modified="2007-02-06" version="1">MSRQAGVSYYVKNALLARPYILVAIQQGIVNYSALAKLLHADIEKMAGRKFTEISVKMAVLRVSKSLLEAVPPTHRLSRVLANSSLKVVQDVGVLSVTREGFEKLTSFLPIGSRGKTPQLFHVVQGASAVTVIADEPVVASLYSKASPETVLQYLRNQAAVILTGPPEILTTPGVVSLISLSVAVRGVNLTEIVSCHRDIVLIVNGSDVALAFETLRSLVEFAKTEQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS1</accession>
    <name>SYFB_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
        <name type="ordered locus">Tpen_0951</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYS1"/>
    <dbReference type="SMR" id="A1RYS1"/>
    <dbReference type="STRING" id="368408.Tpen_0951"/>
    <dbReference type="EnsemblBacteria" id="ABL78351">
        <property type="protein sequence ID" value="ABL78351"/>
        <property type="gene ID" value="Tpen_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0951"/>
    <dbReference type="eggNOG" id="arCOG00412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00284">
        <property type="entry name" value="Phe_tRNA_synth_beta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022918">
        <property type="entry name" value="Phe_tRNA_ligase_beta2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000022430" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00284"/>
        </source>
    </evidence>
    <sequence length="556" mass="61599" checksum="B03ECFE4D3A96F45" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS4</accession>
    <name>A1RYS4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0954"/>
    <dbReference type="EnsemblBacteria" id="ABL78354">
        <property type="protein sequence ID" value="ABL78354"/>
        <property type="gene ID" value="Tpen_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0954"/>
    <dbReference type="eggNOG" id="arCOG09424">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253650_0_0_2"/>
    <dbReference type="OMA" id="YFRTASM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="196" mass="21395" checksum="05869E5A854E10DC" modified="2007-02-06" version="1">MGLDRYAELAELAGRMRGYFENVVTAVNFFTYGMLTGAYFSVVWGFPELWEYRYAVLAGFTALMVVAYAVTSRFASRAPRVEVWRWVASFLAPLPVFYVVAVATGSEAAAASAWYLYVGLFLLLVYVSFGGAEWSKPFLVASSTMLATYPAVLYLSLARGYAANLVALGLMLASYYAAGIYALRRAHRALEGGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT4</accession>
    <name>A1RYT4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2075 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0964"/>
    <dbReference type="EnsemblBacteria" id="ABL78364">
        <property type="protein sequence ID" value="ABL78364"/>
        <property type="gene ID" value="Tpen_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0964"/>
    <dbReference type="eggNOG" id="arCOG04708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019642_0_0_2"/>
    <dbReference type="OMA" id="HTCQGLE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2075" evidence="1">
        <location>
            <begin position="230"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="600" mass="66980" checksum="43EB63915CB63B1C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT6</accession>
    <name>A1RYT6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752631.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0966"/>
    <dbReference type="EnsemblBacteria" id="ABL78366">
        <property type="protein sequence ID" value="ABL78366"/>
        <property type="gene ID" value="Tpen_0966"/>
    </dbReference>
    <dbReference type="GeneID" id="4600440"/>
    <dbReference type="KEGG" id="tpe:Tpen_0966"/>
    <dbReference type="eggNOG" id="arCOG12285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337301_0_0_2"/>
    <dbReference type="OrthoDB" id="135559at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="788" mass="89546" checksum="3005FD12380F863C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW0</accession>
    <name>A1RYW0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein Tpen_0990</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0990"/>
    <dbReference type="EnsemblBacteria" id="ABL78390">
        <property type="protein sequence ID" value="ABL78390"/>
        <property type="gene ID" value="Tpen_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0990"/>
    <dbReference type="eggNOG" id="arCOG02287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_3_2_2"/>
    <dbReference type="OMA" id="VDFEISM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="114" mass="12101" checksum="4BCCAF70766647A6" modified="2007-02-06" version="1">MEAEHVIISTTHSVPGYRVVKVLGIVTGMRVRTRGVLGRLAASVEALVGGRGEAYIEELKKARDEALQDMVAEASKLGANAVIGVNFETSEILEGFIVVTATGTAVVIEPEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW8</accession>
    <name>A1RYW8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752663.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0998"/>
    <dbReference type="EnsemblBacteria" id="ABL78398">
        <property type="protein sequence ID" value="ABL78398"/>
        <property type="gene ID" value="Tpen_0998"/>
    </dbReference>
    <dbReference type="GeneID" id="4601554"/>
    <dbReference type="KEGG" id="tpe:Tpen_0998"/>
    <dbReference type="eggNOG" id="arCOG01203">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1727332_0_0_2"/>
    <dbReference type="OMA" id="CEADEYS"/>
    <dbReference type="OrthoDB" id="101669at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="151" mass="16986" checksum="19C0D1F08DD5411F" modified="2007-02-06" version="1">MLLEGVKSRLSSLRDPCVKAVLVFGSVARGEQGERSDLDLLVLHEGCAIEDPVARRRYFYALLREAVGDLFEDLTVLDMELKRFLEPGEVSPLLLNVYWDAVVVYDATGLVEGFLRRAREGIVRSGLRRVKDGKAYRWILPKPAGVVRVLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-01-20" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX5</accession>
    <name>NTPTH_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside-triphosphatase THEP1</fullName>
            <shortName evidence="1">NTPase THEP1</shortName>
            <ecNumber evidence="1">3.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_1005</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEP1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYX5"/>
    <dbReference type="SMR" id="A1RYX5"/>
    <dbReference type="STRING" id="368408.Tpen_1005"/>
    <dbReference type="EnsemblBacteria" id="ABL78405">
        <property type="protein sequence ID" value="ABL78405"/>
        <property type="gene ID" value="Tpen_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1005"/>
    <dbReference type="eggNOG" id="arCOG01034">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103145_1_1_2"/>
    <dbReference type="OMA" id="GAMEFKC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="PTHR43146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000360030" description="Nucleoside-triphosphatase THEP1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00796"/>
        </source>
    </evidence>
    <sequence length="182" mass="19393" checksum="E98CEC1F239E54E8" modified="2007-02-06" version="1">MAAKNFLLTGRPGIGKTTCVVKTAELLVSRGVKVGGMVTHEVREGGSRVGFKVRDLLTGREGFLAKVGAGAGPRVGKYVVHVEELEAVGVGAILRAVSEAQVVVIDEIGPMELYSPSFLPAVLKALDSDKPVLATIHERESSSGRLRGILERGDVKLYTVTLQNRDLLPPQLAREIASLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY3</accession>
    <name>A1RYY3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752678.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1013"/>
    <dbReference type="EnsemblBacteria" id="ABL78413">
        <property type="protein sequence ID" value="ABL78413"/>
        <property type="gene ID" value="Tpen_1013"/>
    </dbReference>
    <dbReference type="GeneID" id="4600686"/>
    <dbReference type="KEGG" id="tpe:Tpen_1013"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_3_2"/>
    <dbReference type="OMA" id="THAANII"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030827">
        <property type="entry name" value="Myo_inos_IolG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04380">
        <property type="entry name" value="myo_inos_iolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="337" mass="37477" checksum="FBB3DE7C04F573C3" modified="2007-02-06" version="1">MPKVRIGVAGLGRIGRVHAEIILTRLENAELVAVADVVESLARSVGEKYRVKWYTNFDAMLKDPEVDAVFITTPTNLHKEMIVKAAEAGKHVFTEKPITVTVEEAREAVRAAEKAGVKLMVGYMRRFDDAYSAAKARIARGEIGEPLVFINIARDPGPPPGWAQDPRLSGGIFLDMLSHDFDMARFLVGREVKEVYVKGEAALYDEIRQKGDLDLVTISFTFEGKGYGLIHGSRKSVFGYDLRTEVLGTEGTVYVGSQVDPNLAVGTKQGLSYRGVQWFWSRFYDAYVREDEAFVSSILKDEEPPITGVDGLRVVEIAEACWKSWREGRPVTVERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ11</accession>
    <name>A1RZ11_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="11">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">Tpen_1041</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="11"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752706.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1041"/>
    <dbReference type="EnsemblBacteria" id="ABL78441">
        <property type="protein sequence ID" value="ABL78441"/>
        <property type="gene ID" value="Tpen_1041"/>
    </dbReference>
    <dbReference type="GeneID" id="4600946"/>
    <dbReference type="KEGG" id="tpe:Tpen_1041"/>
    <dbReference type="eggNOG" id="arCOG01074">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_11_1_2"/>
    <dbReference type="OMA" id="FRADSYN"/>
    <dbReference type="OrthoDB" id="77530at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABL78441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="154" mass="17690" checksum="2028556B6CED30C1" modified="2007-02-06" version="1">MWIATLCYLLRGDEVLLIRKLRGFGAGKYNGVGGKVEEGEDIWRAAMREVLEETGVEVKGLSYRGLLEFYAGGEEPEIIVHVFVSRDFAGEARPSDEAVPTWFKVGEIPYDEMWEDDRVWLPRVLEGRCVYGRFWFSGGFEKMLRYELSVYDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ13</accession>
    <name>A1RZ13_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1043"/>
    <dbReference type="EnsemblBacteria" id="ABL78443">
        <property type="protein sequence ID" value="ABL78443"/>
        <property type="gene ID" value="Tpen_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1043"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677270_0_0_2"/>
    <dbReference type="OMA" id="AIAGQCY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="40"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="440" mass="47615" checksum="A2BA90CCD1B8E103" modified="2007-02-06" version="1">MLHEARAACKKVLIPEGFSRFPVGGWLGRVRESLGRVPRNIKVLALGWLVWSPVQAMAGPYTQLYVSRLGASPEDISLVQSATQVANALSRIVGGFLSDRYGRKRVLWVGTFLVALAYLLMSVATDWRSYAIASVLNGFALFYQPALEGIQADSVPLHLRGRMNALLHLVPGLASSLSPLGGAALVNAYGLVGGVRVIFFLSFVTGVAIAVARLLWIEETLEPRGSGVNMLESYVDALRHVSRDVYTLITLDTLFNLVGAMSFLSNYYMYYYLGVDKSELAMLASLGSLVNLGLLIPAGRAVDTRGRNFSITLGFLMGTLSQLFFVLSPPSSSFTLPALIVSTLFGAVGGAFYGLAYSSLRADLVAKEYRGRIYALWGLAPAASWSLGAYIGGWMYSNLGPQTPFVASFMLRVLLTPLALTLFGKLTRKVDLALRNVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ15</accession>
    <name>A1RZ15_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752710.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1045"/>
    <dbReference type="EnsemblBacteria" id="ABL78445">
        <property type="protein sequence ID" value="ABL78445"/>
        <property type="gene ID" value="Tpen_1045"/>
    </dbReference>
    <dbReference type="GeneID" id="4600788"/>
    <dbReference type="KEGG" id="tpe:Tpen_1045"/>
    <dbReference type="eggNOG" id="arCOG05511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519941_0_0_2"/>
    <dbReference type="OrthoDB" id="128702at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="98" mass="11175" checksum="FEF577F103F068CC" modified="2007-02-06" version="1">MSRVSRVNLEKLRSFTSKTGLYSWEEREGRVTVTFSSVALEEVLGENAEIKISGFKEGEDLVVDRVVIVRGGQREEVDPKVLEGWLRYIEQSEKRGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ20</accession>
    <name>A1RZ20_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752715.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1050"/>
    <dbReference type="EnsemblBacteria" id="ABL78450">
        <property type="protein sequence ID" value="ABL78450"/>
        <property type="gene ID" value="Tpen_1050"/>
    </dbReference>
    <dbReference type="GeneID" id="4600793"/>
    <dbReference type="KEGG" id="tpe:Tpen_1050"/>
    <dbReference type="eggNOG" id="arCOG09435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212648_0_0_2"/>
    <dbReference type="OMA" id="GIFISDM"/>
    <dbReference type="OrthoDB" id="106006at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="24271" checksum="2954B780E41FB817" modified="2007-02-06" version="1">MSLVALCAALYAVLGYLTYLGLFAPVIGTVRFWPSVFVPATFAVAFSPLIGGLGAAIGIFISDMAVHGNPLLSLSVGVPANFLGFYAVGAVYRLARDERRVLAGIAVELVATVLALSALYYARILDESFVVASAVALAFTVTPMVVARQSRRIVFAGSTGLMLGSAIIGVGVWAYSQFFVLPTGQAQLPAWAALVWFVWTYLTEIPFIALFVPPTVRVLEKAGLVFEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ22</accession>
    <name>ACYP_THEPD</name>
    <protein>
        <recommendedName>
            <fullName>Acylphosphatase</fullName>
            <ecNumber>3.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acylphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">acyP</name>
        <name type="ordered locus">Tpen_1052</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752717.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZ22"/>
    <dbReference type="SMR" id="A1RZ22"/>
    <dbReference type="STRING" id="368408.Tpen_1052"/>
    <dbReference type="EnsemblBacteria" id="ABL78452">
        <property type="protein sequence ID" value="ABL78452"/>
        <property type="gene ID" value="Tpen_1052"/>
    </dbReference>
    <dbReference type="GeneID" id="4600795"/>
    <dbReference type="KEGG" id="tpe:Tpen_1052"/>
    <dbReference type="eggNOG" id="arCOG01674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_2"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="111329at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000326872" description="Acylphosphatase">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Acylphosphatase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="90" mass="10469" checksum="5B64982E1DCB5976" modified="2007-02-06" version="1">MRAHIYVSGLVQGVFFRASMQEVARSLGVNGWVRNLPDGRVEAVLEGEEGAVLKVIEWARRGPPLARVERVDVEWEEYRGEFRDFYIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ51</accession>
    <name>A1RZ51_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Respiratory-chain NADH dehydrogenase, subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752746.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1082"/>
    <dbReference type="EnsemblBacteria" id="ABL78481">
        <property type="protein sequence ID" value="ABL78481"/>
        <property type="gene ID" value="Tpen_1082"/>
    </dbReference>
    <dbReference type="GeneID" id="4601694"/>
    <dbReference type="KEGG" id="tpe:Tpen_1082"/>
    <dbReference type="eggNOG" id="arCOG01546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="337" mass="36902" checksum="2F1A5CC06266A394" modified="2007-02-06" version="1">MGLVEWIVRLVLSPGVFAPVIFPGLLTALAVLLIVIWAERKIAARVQMRVGPLYVTRHFGGVLQMLADGTRYMFQEFIVPETADKVPYMLAPALALTLAIAPFALIPSAPGFAPVKSPYSLPALLAILASTPLSVLLMGWSSNNKFSIQGAVREAFMTLAYEVPLFLSALSMAILYGSMDLEEIVGRQFLPGALLNPVAAFTFFVAMVMSSGRLPFDIVEGEQEIVAGPYVEYTGIVFGIGMGLAYLKLYALSLLYSLLFLSGWEPLPRALYSVYPGLAGVWLFAKAFTLMLFVVFLRSVYGRYRLDQALRAGWRVYLVLAVVSILLSCLLRVVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ52</accession>
    <name>A1RZ52_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase, chain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752747.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1083"/>
    <dbReference type="EnsemblBacteria" id="ABL78482">
        <property type="protein sequence ID" value="ABL78482"/>
        <property type="gene ID" value="Tpen_1083"/>
    </dbReference>
    <dbReference type="GeneID" id="4601695"/>
    <dbReference type="KEGG" id="tpe:Tpen_1083"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_5_2"/>
    <dbReference type="OMA" id="GICANTC"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="17652" checksum="1355C3CF2CEBE58F" modified="2007-02-06" version="1">MSSYVKNFGGHVRAVLTGLKYLVKPNRITVYYPEYYVEPPEGYRGMIKYYPEKCIQCGLCAMICPAGAMKMYVKKGEKKGRPGVNYQRCIFCGFCVDICPQDALEMTKVHDVAFSSLEELVFPPEKLAVEVQSPALLRGAVKVKPVFDEERGLRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ69</accession>
    <name>A1RZ69_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system mannose/fructose/sorbose family IID component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_1100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752764.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1100"/>
    <dbReference type="TCDB" id="4.A.6.1.24">
        <property type="family name" value="the pts mannose-fructose-sorbose (man) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78499">
        <property type="protein sequence ID" value="ABL78499"/>
        <property type="gene ID" value="Tpen_1100"/>
    </dbReference>
    <dbReference type="GeneID" id="4600967"/>
    <dbReference type="KEGG" id="tpe:Tpen_1100"/>
    <dbReference type="eggNOG" id="arCOG14685">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036800_0_0_2"/>
    <dbReference type="OrthoDB" id="21300at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="534" mass="57507" checksum="586892D3E0289A5A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ70</accession>
    <name>A1RZ70_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752765.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1101"/>
    <dbReference type="EnsemblBacteria" id="ABL78500">
        <property type="protein sequence ID" value="ABL78500"/>
        <property type="gene ID" value="Tpen_1101"/>
    </dbReference>
    <dbReference type="GeneID" id="4600968"/>
    <dbReference type="KEGG" id="tpe:Tpen_1101"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212649_0_0_2"/>
    <dbReference type="OrthoDB" id="110640at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="25700" checksum="3CA9521D4F20925E" modified="2007-02-06" version="1">MSGEWIVVSDYDGTLAEENREVEPRVLEKLEELKAKYPFKFVIATARPLEDISRFVGKLWLVDALILEVGSVVALPEALEVIFKPWGWDRLRAVLRESVPAVNEGRVLYYVDEEELQVAERVAREKLGAFGYDLAKVGSRTYAFMPRGIDKGVGLERLLKLTGWSDAMIVSIGDSRTDLPLFQKSKVKVAVGNAAREVKEKADIVCEEKYGDCVVRVIEEIVNRMSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ94</accession>
    <name>A1RZ94_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate dehydrogenase subunit B</fullName>
            <ecNumber evidence="3">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1126"/>
    <dbReference type="EnsemblBacteria" id="ABL78524">
        <property type="protein sequence ID" value="ABL78524"/>
        <property type="gene ID" value="Tpen_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1126"/>
    <dbReference type="eggNOG" id="arCOG00962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_0_2"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="219" mass="24167" checksum="78A6616F5D086273" modified="2007-02-06" version="1">MRYRLVVRRYKQGWREAEYRAYEVDVDPDTSVLDALEKVSLEQDPTLTFEHACHHGVCGACGMVINGVERLACVTRIGEVARGGVVVVEPLRGFRVVSDLAVDKSRMFSQYALVEPGTLERVDGVVELEKLFDCVECGVCYSACPIANTFPEYLGPSVIALAYRSSKDGKVPAVLDSRRGVWACHAAFECSVRCPVGFKPGETIMKVRRGFLSGKLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA8</accession>
    <name>A1RZA8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate-ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752803.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1140"/>
    <dbReference type="EnsemblBacteria" id="ABL78538">
        <property type="protein sequence ID" value="ABL78538"/>
        <property type="gene ID" value="Tpen_1140"/>
    </dbReference>
    <dbReference type="GeneID" id="4601395"/>
    <dbReference type="KEGG" id="tpe:Tpen_1140"/>
    <dbReference type="eggNOG" id="arCOG00409">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_2_2"/>
    <dbReference type="OMA" id="KVMSSAI"/>
    <dbReference type="OrthoDB" id="80207at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="61"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="364" mass="41911" checksum="6DF7E2BA0A9B6098" modified="2007-02-06" version="1">MGQETRFIAFNSARESLAKLHPAVLELEKMARDRDSYVKFLEEWTRYSWKWARESKYATVFRIQASILRAIREYLDSHGFTEALPPIIGPVTDPGIRGAKQVTVDFYGHEYKVMSSAILYKQYMAAVLGKVYFVSPNIRLEPNDSIFTGRHLVEFFQVDIEILDGTLEDAMSLAEGLFMHVARYVEEVHGADLEKLGRTLPEYRTPFARYTHAEAVELVNRLGCRNPRNTEILWECEKVLSAHHTSPLFIYGYPKGSRGFYNREDPERPGYLRDFDMLYPEGFGEAISGGEREYEPAKVIARIKESGEDPKKYKWFLEMLRDFYPLKTAGFGIGVERLTRYICGLRAVWESRPYPKVAGIGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB1</accession>
    <name>A1RZB1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752806.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78541">
        <property type="protein sequence ID" value="ABL78541"/>
        <property type="gene ID" value="Tpen_1143"/>
    </dbReference>
    <dbReference type="GeneID" id="4600949"/>
    <dbReference type="KEGG" id="tpe:Tpen_1143"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="OrthoDB" id="144493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="477" mass="54955" checksum="375F75A7341C40DF" modified="2007-02-06" version="1">MVGEKMMGYEGVEGEVREETWRRAALSLYSTEVEDKRKGRTHYRGLYHTVSEVDWDFTRFLVNGYSVVPDEVYPRFHRFLDIDARKYLLLNDDSRPREGSAVVELRDRLQSIVDAGADDLRAERHGKHWRVYPPRENWYVRVARPNAHSWAVRVPLEGFWVESEFPEVLVNTPREVLKSLQRGWILTDVTPPHGRRSDVRFGTTQSWQLPSTLAAFPSDDIRLGIKAGVLGSTRMSIEWEVSIYGYTEELGWASTLIGEVKRVEYRRLVDECRKLNGDPVALFTAFLGDGLRTFFLRIRVLFFGIGHEIVYLPTESAVFNARLAVERASEYVRFVSLVTKCPKIKHFLFVSLGLPQKRGRKNGRRNNPFYANIAGAQLLLVYISTMNLVYARIAVDAVPQGWYEKAIEEGWDVRVVTSGTPSGSKKYYAVPQGSLFEHARHDAELRATLLAFTRYKAEQYPRAWELVNRLEKLGREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF5</accession>
    <name>A1RZF5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752850.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1187"/>
    <dbReference type="EnsemblBacteria" id="ABL78585">
        <property type="protein sequence ID" value="ABL78585"/>
        <property type="gene ID" value="Tpen_1187"/>
    </dbReference>
    <dbReference type="GeneID" id="4600432"/>
    <dbReference type="KEGG" id="tpe:Tpen_1187"/>
    <dbReference type="eggNOG" id="arCOG00727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119496_2_0_2"/>
    <dbReference type="OMA" id="WNIGEVL"/>
    <dbReference type="OrthoDB" id="91957at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="149" mass="17206" checksum="266E24D399DDC4DF" modified="2007-02-06" version="1">MTVVYLDSSAVVKRYVLEPGSEVVSRVYYKALNGESTLSFSAWNIGEVLGVLDKYYRRGWLSREDYEKARFQFLGETIRLLKLRLLKIVPVRTKLLIETWRIVEKYHVYEADALQLVSAKYVGAEEFYTGDEQLHKIAAEERVGSVYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF7</accession>
    <name>A1RZF7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752852.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1189"/>
    <dbReference type="EnsemblBacteria" id="ABL78587">
        <property type="protein sequence ID" value="ABL78587"/>
        <property type="gene ID" value="Tpen_1189"/>
    </dbReference>
    <dbReference type="GeneID" id="4600434"/>
    <dbReference type="KEGG" id="tpe:Tpen_1189"/>
    <dbReference type="eggNOG" id="arCOG12287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302685_0_0_2"/>
    <dbReference type="OMA" id="WTESINV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="227" mass="24597" checksum="5FB68F1779A2B670" modified="2007-02-06" version="1">MRGLLALLVALAVSAALISVAVALGSLPYLAGPPPPPKPPAPAAHPEGSGRLLTREEKETLLSVLRRDSFLAPYLSRSNWTVKNLDQLRVYPGSKVEALVELAEPQWIEGLETPKYRASMWARTLIVTVNLTAGRVERVEAVPTRPPRDTPLSPRLEEARRVAASHRLVQSLGPSVNLYLVAVYHSGEYPGGLAVFSAFSDKGEVLVAVDLATMTVVERYTSPVYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH4</accession>
    <name>A1RZH4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752869.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1206"/>
    <dbReference type="EnsemblBacteria" id="ABL78604">
        <property type="protein sequence ID" value="ABL78604"/>
        <property type="gene ID" value="Tpen_1206"/>
    </dbReference>
    <dbReference type="GeneID" id="4600408"/>
    <dbReference type="KEGG" id="tpe:Tpen_1206"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="19042at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="470" mass="52677" checksum="F622D321D7C776CC" modified="2007-02-06" version="1">MSKTSLLESLSLGEVSLDALRLKPRITLKGRISRSLVEEISRSKGEPEWMLRLRLRSLELFEKLPEPNWLVGVDELDLEELAHYVHPDVERVSRWEDLPEDVRKVYERLGLPEIERRVLSGLAAQLESENVYLAFKKFLEKQGVILMDMSEAVQRYPDLVKKYFMRVFPPSDHKFAALHGALWSGGVFLYVPPNVRIEAPIEAFFFIASELESQMEHTIVVADEGSFVHFIEGCAAPMFKKYSFHNGMVEVYAHKGSHVKFTTAQNWSKNLVNFNNKRALVEEGAVVEWVEGSIGSKVSYVYPSAILRGANARVSITNITLAKGPVWKDGGAKVYHLAPSTSSEVVSKSISADGGTAVYRGLVKVARGARGSTAAVKCDSLILDKKSKALTYPRNEVDEEDSTVVHEATTGRLSEEALFYLKTRGLSESEARRLVVLGYVGDVLGKLPFEYQVVFRRVLELEFEEIGGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI4</accession>
    <name>A1RZI4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752879.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1216"/>
    <dbReference type="EnsemblBacteria" id="ABL78614">
        <property type="protein sequence ID" value="ABL78614"/>
        <property type="gene ID" value="Tpen_1216"/>
    </dbReference>
    <dbReference type="GeneID" id="4601628"/>
    <dbReference type="KEGG" id="tpe:Tpen_1216"/>
    <dbReference type="eggNOG" id="arCOG06105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186535_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="88" mass="9211" checksum="BB02C6A508001894" modified="2007-02-06" version="1">MSNRKIAALLLASGAALIVLVFVLAVQAALSYQKPQIGGDAGAAFSSMLSEVLYLFGKAVFLFVAILAASHLLKNGVELLKSEGFMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK1</accession>
    <name>A1RZK1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1233"/>
    <dbReference type="EnsemblBacteria" id="ABL78631">
        <property type="protein sequence ID" value="ABL78631"/>
        <property type="gene ID" value="Tpen_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1233"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="GNVMFWP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="25405" checksum="A2B4229E42D2CEF7" modified="2007-02-06" version="1">MRLVSFDVWGTLLRIEPFYEAAARAMEELGILGFREALDLLVKGYREVKGARRLGAIDPGDVIGSSVAVALGSSGAGLTKGDVFLAFARAANRVSVSDLLIPGSLETVERLHEEGYSLAVASNVIYWPGYVTRVLLDRAGFSRFFRVQVYADEVGRLKPDPGFFAELLRLTGAPREGVVHVGDSPQEDLAGALAAGVAGVLVDGGRGEAFVDESLRIAVVRRLEEVPGVIPRLLRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP4</accession>
    <name>A1RZP4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1276"/>
    <dbReference type="EnsemblBacteria" id="ABL78674">
        <property type="protein sequence ID" value="ABL78674"/>
        <property type="gene ID" value="Tpen_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1276"/>
    <dbReference type="eggNOG" id="arCOG03724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514692_0_0_2"/>
    <dbReference type="OMA" id="VITHWIL"/>
    <dbReference type="OrthoDB" id="137702at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="177" mass="20147" checksum="9FBAF80F3453052F" modified="2007-02-06" version="1">MSVSAEYIVKLFEEDPKSRKRLAELLVSEPDVRLALINAVIRDVATKHDVEKHWEATRRDIEGLRRELEGLERDVASLAERVSRLEGAYAELSKRIDSLGERISDLDKRIDSLDKRIDGLDKRIDSLDKRIESLDKRIDSLDKRLDHIAKISYTLTASVLATLAASIILLAIIRIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ7</accession>
    <name>A1RZQ7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752952.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1289"/>
    <dbReference type="EnsemblBacteria" id="ABL78687">
        <property type="protein sequence ID" value="ABL78687"/>
        <property type="gene ID" value="Tpen_1289"/>
    </dbReference>
    <dbReference type="GeneID" id="4600597"/>
    <dbReference type="KEGG" id="tpe:Tpen_1289"/>
    <dbReference type="eggNOG" id="arCOG02660">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835817_0_0_2"/>
    <dbReference type="OMA" id="RYINEEW"/>
    <dbReference type="OrthoDB" id="87074at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="332" mass="35483" checksum="15BD6EF3F9E62A23" modified="2007-02-06" version="1">MQASGSAVRVARRAPRSRSVLEGLAGRLEVALVADSYLHVGSGVQRVSVPVEEVRSSASRARTRRELEDLVARLSGKIELDYAQPVYAGGRLVVPGSSVKGNVRSRLELSFKPKNGVARSCLIRATEGPVAPPKKGEQGWRHFRVWEASLSYPGREACEYSEDSPEVCLLCDIFGTAGLQGLVYFGDLVAARAETERVELYAGEKLLAVKPGGRFEGAVTFRNLKPAELGLLLYGMGFRDGRMGRQVLLGKHKYSSPGERFGVVHFELEGLALAPFSEKLEVGGASLAPGSRASGAELDRLVSALVGAARSEFGDELLDVDEVGAVESLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR1</accession>
    <name>A1RZR1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752956.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1293"/>
    <dbReference type="EnsemblBacteria" id="ABL78691">
        <property type="protein sequence ID" value="ABL78691"/>
        <property type="gene ID" value="Tpen_1293"/>
    </dbReference>
    <dbReference type="GeneID" id="4600647"/>
    <dbReference type="KEGG" id="tpe:Tpen_1293"/>
    <dbReference type="eggNOG" id="arCOG02658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1197672_0_0_2"/>
    <dbReference type="OMA" id="NCPVERL"/>
    <dbReference type="OrthoDB" id="107324at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="288" mass="30768" checksum="A8EEC3FA59825F42" modified="2007-02-06" version="1">MVGLGRAQFQAKFAAILAFEARGPLHVGGRREGNVLYALRLPDGRLLVPGSTWKGAFRSIAEKLAPSIPATGPEKLALELAAAGERGRDAYLEKLRGDFEAALKGAATRFDPADVKRVVGELGLDREAGIDAREALEQYLEYYCPVGKLFGNRVRAGSLKFADSVVEAPTFRKPGVGIDRKTGTVKEGVLYFVEAGDPGAPVKLLMVGEVDERGSAASRLLASTLLYVKELGVAVGGKKSTGMGLLELRDARIHVVEYAADKGGAMLAQLLKTKPMGVEEFAAWLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR9</accession>
    <name>A1RZR9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752964.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1301"/>
    <dbReference type="EnsemblBacteria" id="ABL78699">
        <property type="protein sequence ID" value="ABL78699"/>
        <property type="gene ID" value="Tpen_1301"/>
    </dbReference>
    <dbReference type="GeneID" id="4600655"/>
    <dbReference type="KEGG" id="tpe:Tpen_1301"/>
    <dbReference type="eggNOG" id="arCOG01205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159724_0_0_2"/>
    <dbReference type="OMA" id="ERKYDIM"/>
    <dbReference type="OrthoDB" id="122104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="103" mass="11729" checksum="1F4BE1C1A0B6EFD9" modified="2007-02-06" version="1">MSRGSALRFLRDYRAVAGLVKEVARRFDPEARVFVFGSAVRGDYTAASDIDVLVVTSAVDRKYDLMVEVYRSTEAPVELHVASPEQFEKWYKRFIPPSELVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S006</accession>
    <name>A1S006_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753051.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1389"/>
    <dbReference type="EnsemblBacteria" id="ABL78786">
        <property type="protein sequence ID" value="ABL78786"/>
        <property type="gene ID" value="Tpen_1389"/>
    </dbReference>
    <dbReference type="GeneID" id="4600672"/>
    <dbReference type="KEGG" id="tpe:Tpen_1389"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_0_1_2"/>
    <dbReference type="OMA" id="RVNWAEE"/>
    <dbReference type="OrthoDB" id="131018at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="PTHR42244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="77" mass="9064" checksum="00D0976E3E7D1A79" modified="2007-02-06" version="1">MSATVSFKVRREVKEKMLRYRDRVDWPEELRRFVEEKIREIEARENIERVVSELESIPAGVPRGFAAASVREDRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S055</accession>
    <name>A1S055_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1438"/>
    <dbReference type="EnsemblBacteria" id="ABL78835">
        <property type="protein sequence ID" value="ABL78835"/>
        <property type="gene ID" value="Tpen_1438"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1438"/>
    <dbReference type="HOGENOM" id="CLU_736978_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="375" mass="37950" checksum="F240B2BEA062B7FD" modified="2007-02-06" version="1">MVRVSMPAGSRVHPGRRSPSGIRGFRRPPPSLRRANNPPGLRRGQEGGRPRPAVHSLVHPRLHSRRTLGAKPPSAAPDPPSPPSARPGSGPRVVRRFEVRPAPILDPEAPERVNAVLEVSYSIAMVAGPPLAAWMASAGPAGISAAVALELSALALLTAVLARRGLNAPIGPGGGFLQALCRLAGSRAPRLALVLSTAISGVGALVNVSVALVAGRLGEVLPGFTASYSLLSALTGLGSLAASALAARRGVLGEGFLYAGLLLLSAYPALLGLSMSAEPSLLLATILLAFSTLNGFGNGAFFLWILSAVQRSMGGDVGKALATLYVLGALAGLPFSLAAGIAAQSLPALLVASSVLLASLPATAALATRFSPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S056</accession>
    <name>A1S056_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1439"/>
    <dbReference type="EnsemblBacteria" id="ABL78836">
        <property type="protein sequence ID" value="ABL78836"/>
        <property type="gene ID" value="Tpen_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1439"/>
    <dbReference type="eggNOG" id="arCOG01879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1280846_0_0_2"/>
    <dbReference type="OMA" id="YNRKIIH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="238" mass="26494" checksum="FFF841793178B8BE" modified="2007-02-06" version="1">MKSALPSVVTPQEVGWTIALFAWVMFVVLVVAKATYNFFVKRSNERVAIYYARKVIHILAGGLVAAVIAYFPIFSTPVLPFAMAMVLALLTYLPHRTGKLMYWFQDPENIYEVDFCLMWGVFVVLGWFVGRDLKLANPFLFPALPLLFMAVGDGVTGIVRNALFKRRVKHWSGNLAMFIVSAAMAVAMGFGVPGVLSAALASLVERWEYIGKLRIDDNVSVPTVSFAALYLLTRYVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S090</accession>
    <name>A1S090_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753135.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1473"/>
    <dbReference type="EnsemblBacteria" id="ABL78870">
        <property type="protein sequence ID" value="ABL78870"/>
        <property type="gene ID" value="Tpen_1473"/>
    </dbReference>
    <dbReference type="GeneID" id="4601574"/>
    <dbReference type="KEGG" id="tpe:Tpen_1473"/>
    <dbReference type="eggNOG" id="arCOG05414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194227_0_0_2"/>
    <dbReference type="OMA" id="SHAFNIM"/>
    <dbReference type="OrthoDB" id="124303at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="88" mass="10205" checksum="29D407839BE9C8CE" modified="2007-02-06" version="1">MSVTVSIKVRKEVAQLAEKMVRYGLARNRSHAFNIMIERGLEEVKREVAFWDEVYRSAEELEKSGFRLRHGGLSRLLEEGRERSSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1S097</accession>
    <name>A1S097_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">Tpen_1480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753142.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1480"/>
    <dbReference type="EnsemblBacteria" id="ABL78877">
        <property type="protein sequence ID" value="ABL78877"/>
        <property type="gene ID" value="Tpen_1480"/>
    </dbReference>
    <dbReference type="GeneID" id="4601275"/>
    <dbReference type="KEGG" id="tpe:Tpen_1480"/>
    <dbReference type="eggNOG" id="arCOG01577">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_2"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="17967at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="701" mass="76133" checksum="EC064C32A95D3224" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C1</accession>
    <name>A1S0C1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753166.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1504"/>
    <dbReference type="EnsemblBacteria" id="ABL78901">
        <property type="protein sequence ID" value="ABL78901"/>
        <property type="gene ID" value="Tpen_1504"/>
    </dbReference>
    <dbReference type="GeneID" id="4601205"/>
    <dbReference type="KEGG" id="tpe:Tpen_1504"/>
    <dbReference type="eggNOG" id="arCOG15106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597937_0_0_2"/>
    <dbReference type="OrthoDB" id="141930at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="9594" checksum="99C1AF0ADB40BD03" modified="2007-02-06" version="1">MARRMALRKLLGYLEKCELISDEELMEIEDRLSRGEDVLEMGIRVLGYDEKKEDYVVEVEDLEGLLSENGYNPDYVRYQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C9</accession>
    <name>A1S0C9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753174.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1512"/>
    <dbReference type="EnsemblBacteria" id="ABL78909">
        <property type="protein sequence ID" value="ABL78909"/>
        <property type="gene ID" value="Tpen_1512"/>
    </dbReference>
    <dbReference type="GeneID" id="4601108"/>
    <dbReference type="KEGG" id="tpe:Tpen_1512"/>
    <dbReference type="eggNOG" id="arCOG14947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954777_0_0_2"/>
    <dbReference type="OrthoDB" id="136317at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="128" mass="14910" checksum="CE6C2F9FC6E08F09" modified="2007-02-06" version="1">MAVQWSVKSVKDYVDACSETRLREQCVREAEESVGTWVYRASYSFFLSGVLGRAIQRVPPDIAWKVHEYLVVKPRSRIPFDEQLYRVLIEVFRAVEESPATPEEKLHARRLRELVETALALRSSIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D8</accession>
    <name>A1S0D8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753183.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1521"/>
    <dbReference type="EnsemblBacteria" id="ABL78918">
        <property type="protein sequence ID" value="ABL78918"/>
        <property type="gene ID" value="Tpen_1521"/>
    </dbReference>
    <dbReference type="GeneID" id="4600658"/>
    <dbReference type="KEGG" id="tpe:Tpen_1521"/>
    <dbReference type="eggNOG" id="arCOG07466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108881_1_0_2"/>
    <dbReference type="OMA" id="VYWRGGL"/>
    <dbReference type="OrthoDB" id="88522at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="201" mass="21685" checksum="AC3B21C176622261" modified="2007-02-06" version="1">MRAAYSYVYALLPALLWPLAFLAFREVFVQAMLGATLVLAISTVAFRRGALRLGAGAREVALGLLAAIPLYLVFVAGKHFLAALGYFYAVEQVYSMVRESARRDLLLATALCAIGASEEVYWRGGLLSFLVERFGSTRAALAVMVSYYTLVHVYTLNPALMLGALVVGAYTGLVATRLGLAAAVSTHVAWLYLVILLFPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H6</accession>
    <name>A1S0H6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753221.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1561"/>
    <dbReference type="EnsemblBacteria" id="ABL78956">
        <property type="protein sequence ID" value="ABL78956"/>
        <property type="gene ID" value="Tpen_1561"/>
    </dbReference>
    <dbReference type="GeneID" id="4601519"/>
    <dbReference type="KEGG" id="tpe:Tpen_1561"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OMA" id="NWGLMRE"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="13"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="252" mass="27650" checksum="BBEF643F0AAFC874" modified="2007-02-06" version="1">MAVDKVLAFVELELRRLRHDPTEVFTRAVQPALWIGVFGTVMSRVRAIPTGSVDYLTFIAPGVLMQSTSFIAIAYGIMLVWERDSGILKRVLTLPVNRFLIVLGRSLSGATRALSQLFVVLLIALPLGARLNVNPLALCLAALAVYVCSTGLTALSIIMASAMKTRERFMGIIQAITMPLFFTSNALYPVEFMPQPLQYVSLFNPLTYTIQALRASLIYCDYWSTLANTGILATFSLAMLLAATAALPRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I0</accession>
    <name>A1S0I0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1565"/>
    <dbReference type="EnsemblBacteria" id="ABL78960">
        <property type="protein sequence ID" value="ABL78960"/>
        <property type="gene ID" value="Tpen_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1565"/>
    <dbReference type="HOGENOM" id="CLU_961787_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="289" mass="30991" checksum="B1518DA3F7CA0393" modified="2007-02-06" version="1">MEGVRRVVGVKGSVILATLLVATLLVAAAARAEPSKIKGVLYDVKILGWEYREDLESGVFTLNLTVSFKMANCSDSALVVPLGLSFVSANLTKASVVLDGEELAGKAKLVTKPLSRVEIALKKPVSGPKWATVTVSIVCQVKSGAKIQSGYAKDYTPVSDKVLNIPVTNYFTSVSWEKDGDLPGVRIRVCPPSGWNAVYAVSSITSKVATLDIRRVDSCFEFWNLDEKTVTPKSLSPGSSFSAEVAVLPAPSPSQPHVALVALALVAAACFFAWYYRDVYRYVELKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J2</accession>
    <name>A1S0J2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753237.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1577"/>
    <dbReference type="EnsemblBacteria" id="ABL78972">
        <property type="protein sequence ID" value="ABL78972"/>
        <property type="gene ID" value="Tpen_1577"/>
    </dbReference>
    <dbReference type="GeneID" id="4600563"/>
    <dbReference type="KEGG" id="tpe:Tpen_1577"/>
    <dbReference type="eggNOG" id="arCOG01269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_0_2"/>
    <dbReference type="OMA" id="MLIWSRN"/>
    <dbReference type="OrthoDB" id="82041at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="34480" checksum="2840D3787AEACB5F" modified="2007-02-06" version="1">MLPGYPYSILNFFQYTFFYILFSIPLTLSYRNTKVINFAHANFISYGIYTAVFLNGLLGNTSLALACLAAFAVGGSIALVNHLLVFRPLEKRGASMSLIMIASMGLWIMYNYALYMLADIAHYYTLKNFISYGRIVYADVPEVELLGLRLQQSFVAGGLAALVLVASLYLFLEKTTLGKAMRAVADNPVLAEISGIPRNTIVNLTWLIAGGAAAVGGAIWTSFSGTVTPTSADAMILQVFTVSFIGGLVSLLRTGLGAVAIAFIENVGIAALNTYFGVPISFRPFLTFVTLLTILIAFPPLGAAGGLPFRFRSRKVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M5</accession>
    <name>A1S0M5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753270.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="SMR" id="A1S0M5"/>
    <dbReference type="STRING" id="368408.Tpen_1610"/>
    <dbReference type="EnsemblBacteria" id="ABL79005">
        <property type="protein sequence ID" value="ABL79005"/>
        <property type="gene ID" value="Tpen_1610"/>
    </dbReference>
    <dbReference type="GeneID" id="4601902"/>
    <dbReference type="KEGG" id="tpe:Tpen_1610"/>
    <dbReference type="eggNOG" id="arCOG00815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_9_2_2"/>
    <dbReference type="OrthoDB" id="130137at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="79" mass="9229" checksum="4BFD00D7328D3500" modified="2007-02-06" version="1">MSESVRVGKRFTVVIPKSVREKVGLKEGDLLEVRVEGGRIVLERKDFNPFKVLAEVIGEPYREERDERKAEEWLRNACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U7</accession>
    <name>A1S0U7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79077">
        <property type="protein sequence ID" value="ABL79077"/>
        <property type="gene ID" value="Tpen_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1682"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496635_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="HEPN" evidence="2">
        <location>
            <begin position="412"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="548" mass="59444" checksum="D303D0F23A33C362" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W4</accession>
    <name>A1S0W4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753359.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1699"/>
    <dbReference type="EnsemblBacteria" id="ABL79094">
        <property type="protein sequence ID" value="ABL79094"/>
        <property type="gene ID" value="Tpen_1699"/>
    </dbReference>
    <dbReference type="GeneID" id="4601022"/>
    <dbReference type="KEGG" id="tpe:Tpen_1699"/>
    <dbReference type="eggNOG" id="arCOG03723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142665_0_0_2"/>
    <dbReference type="OrthoDB" id="119779at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="155" mass="18187" checksum="20CC9F3621B9C40E" modified="2007-02-06" version="1">MAEEDVTLVTAEEILKYAEEEFEKAIKTRDVMLYRNAADKAFFSMVLAVNSYIYRKMNVTPKSHSERRSLLRKMNREDLRALYSDIMKTLHDEAFYEGVYNPKEAEYAIKQVKKMLEEFKKARATSARRQPHSLRVIDEHTIYTSRESPLPTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W9</accession>
    <name>A1S0W9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753364.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1704"/>
    <dbReference type="EnsemblBacteria" id="ABL79099">
        <property type="protein sequence ID" value="ABL79099"/>
        <property type="gene ID" value="Tpen_1704"/>
    </dbReference>
    <dbReference type="GeneID" id="4601666"/>
    <dbReference type="KEGG" id="tpe:Tpen_1704"/>
    <dbReference type="eggNOG" id="arCOG07756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032977_0_0_2"/>
    <dbReference type="OMA" id="KMNIFLA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="121" mass="13064" checksum="48ED8D0C1E23E760" modified="2007-02-06" version="1">MRAHKPPGREPVLLEAPGLQNAPVLEARLLHDESIGTYLQVTLSCGAREALELWERAAGAARLLGVPVLIYWTGPTDPPPSELGARLGRILAKMGVFLATKEPIDTLQALKEERATSPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S114</accession>
    <name>A1S114_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753409.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1749"/>
    <dbReference type="EnsemblBacteria" id="ABL79144">
        <property type="protein sequence ID" value="ABL79144"/>
        <property type="gene ID" value="Tpen_1749"/>
    </dbReference>
    <dbReference type="GeneID" id="4601774"/>
    <dbReference type="KEGG" id="tpe:Tpen_1749"/>
    <dbReference type="eggNOG" id="arCOG07758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014193_0_0_2"/>
    <dbReference type="OMA" id="WDNILKI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="274" mass="29433" checksum="0FFBEDC2FA9F5A1B" modified="2007-02-06" version="1">MKFYDPEELLGALVVDSAGLVYGVVGGYRLAPEGVVLEAYVSLGVDADALRRALRERGVEPGGEGVEALVLAARRLGLEVPRVGGREVRVLKGLVRPGEISLIDVRVLENPSTGAEERIGVVLLGSQREAEFRGLRFSGGPVVDEGVVGKLCVSASNGVLGYVYGFVVGAGESGLRACRRRGRVELNWASFLSEARRLAGEDAYYRLVGFRDPLKSPRLSGAEVEEARRLLSEMGLLERLSPLLESHSKRTGPAECADVPLRDVLAAREVVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1S140</accession>
    <name>A1S140_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753435.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1775"/>
    <dbReference type="EnsemblBacteria" id="ABL79170">
        <property type="protein sequence ID" value="ABL79170"/>
        <property type="gene ID" value="Tpen_1775"/>
    </dbReference>
    <dbReference type="GeneID" id="4601936"/>
    <dbReference type="KEGG" id="tpe:Tpen_1775"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="NICKFYS"/>
    <dbReference type="OrthoDB" id="67630at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="298" mass="32732" checksum="301DD69A095F2C09" modified="2007-02-06" version="1">MSEEALVLRDIWKIYRTQSEEIPVLKGVNLSVNQGELAIIMGPSGSGKSTLLSIAGGLERPSKGRVIVGGVDITDLDEDELTKIRARKIGFVFQSFNLIRNLTAVENVMMPLIFTGMYSWRQAREIALKMLEIVGLKGHEEKFPRQLSGGQQQRVAIARALAPSPDIILMDEPTGSLDVDSASRVLSLVKWLNEAFGQTIIIVTHNPEIAELATRTFYIRGGEIYQQPPTSTLADKVKELKSSAGYGSFAKVQLDLLKIKLEALEAAAKQGKIPPEVLEGELKSLEARISKLEKYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S186</accession>
    <name>A1S186_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753481.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1821"/>
    <dbReference type="EnsemblBacteria" id="ABL79216">
        <property type="protein sequence ID" value="ABL79216"/>
        <property type="gene ID" value="Tpen_1821"/>
    </dbReference>
    <dbReference type="GeneID" id="4602058"/>
    <dbReference type="KEGG" id="tpe:Tpen_1821"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="OrthoDB" id="67908at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="264" mass="28724" checksum="6BFD4D3D354E8318" modified="2007-02-06" version="1">MALKIDLSGKLSLTTASSRGIGFGVARVLARCGSDVILVSRSAEGLEKARSAILSESPVDVFTVQADLTRREDLERMVKEVLGIGVPDVFFYSTGGPRPGSFLELSMDDWDSAYRLLVYPAVYITRSILPGMVEKRWGRLIYLSSLAIKEPMPNLALSNVMRIAIAGLVRTLAREVGRYGITVNGIMPGTIKTSRVEELAADIARRQGVSLDEAYRQLARDIPAGRLGYPEEIGYLVAFLASDYASYINGAMIPVDGGRQVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A7</accession>
    <name>A1S1A7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751362.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1842"/>
    <dbReference type="EnsemblBacteria" id="ABL79237">
        <property type="protein sequence ID" value="ABL79237"/>
        <property type="gene ID" value="Tpen_1842"/>
    </dbReference>
    <dbReference type="GeneID" id="4600318"/>
    <dbReference type="KEGG" id="tpe:Tpen_1842"/>
    <dbReference type="HOGENOM" id="CLU_884606_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="314" mass="33425" checksum="6D360AF7F3207E45" modified="2007-02-06" version="1">MRAGSYKVALVHYTAIAVAGILLAYVALRAFLLLGILYVIGAVGGLIVSLVVGALAGAIPGRGEAKPNNPWTLVMPVALNAAILFSLVSYGYSNLALMGTSMVVLFLANRGFKPPEPDMARGVIGGFAAFIVVLVLSLLTNLFLQGRLEPLGGYNGTLLYTGIAPAASSGGLEAQFWAFIMLFVVAVSEEMWRAATYYNVLANSSHRLATVIATTWFLFMHVPSRMQYGLQAPVIIALIGIATLTMWFFARGDIWAMVVAHGIYNTALAGIAYGMLPVELLLLAIFVYAVWYSGSGVTVEIPEKVAEKVKGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B8</accession>
    <name>A1S1B8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751373.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79248">
        <property type="protein sequence ID" value="ABL79248"/>
        <property type="gene ID" value="Tpen_1853"/>
    </dbReference>
    <dbReference type="GeneID" id="4600315"/>
    <dbReference type="KEGG" id="tpe:Tpen_1853"/>
    <dbReference type="HOGENOM" id="CLU_1192674_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="232" mass="25658" checksum="45B69668C2AC88CC" modified="2007-02-06" version="1">MWLLVFDPVEAKALYARIEEMGFLETELVMVAKVVFSTFDKMDDGVKRAKRAASKWWNIPAKIAIRLFPSWYYMHMAPSYLFHAPQSLAASVDTGKGALHLLWADVVEVNKAEYQLVSLFKNVEDVKSFLEGEKVFKRALALATARKHDEIAEMSKAVAEIITVSARILKTIVDNIPGSYDIIEQVLSKYNVKGETVVEFATSEAVARQLLAKLKEMAGAPAPAGAPAPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D1</accession>
    <name>A1S1D1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1866"/>
    <dbReference type="EnsemblBacteria" id="ABL79261">
        <property type="protein sequence ID" value="ABL79261"/>
        <property type="gene ID" value="Tpen_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1866"/>
    <dbReference type="HOGENOM" id="CLU_437852_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="624" mass="67481" checksum="BDECD0DF8CE2FF34" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E9</accession>
    <name>A1S1E9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1884"/>
    <dbReference type="EnsemblBacteria" id="ABL79279">
        <property type="protein sequence ID" value="ABL79279"/>
        <property type="gene ID" value="Tpen_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1884"/>
    <dbReference type="HOGENOM" id="CLU_2930398_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="60" mass="6337" checksum="F8750C8895342178" modified="2007-02-06" version="1">MVKVKLDRNTLALASCEALESLANGFRLMGQVQAATYIENIARAKGCPVGGAGYTPQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW56</accession>
    <name>A1RW56_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751701.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0026"/>
    <dbReference type="EnsemblBacteria" id="ABL77436">
        <property type="protein sequence ID" value="ABL77436"/>
        <property type="gene ID" value="Tpen_0026"/>
    </dbReference>
    <dbReference type="GeneID" id="4601063"/>
    <dbReference type="KEGG" id="tpe:Tpen_0026"/>
    <dbReference type="eggNOG" id="arCOG02872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607815_0_0_2"/>
    <dbReference type="OMA" id="TPSFAVW"/>
    <dbReference type="OrthoDB" id="74659at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="263"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="433" mass="46923" checksum="82EE2640CF871331" modified="2007-02-06" version="1">MDKKVVYALLAVAVAVAAGLSLLLLKQAAPPGSVQQPQPSCQPTSLVYVYLDEAQKNLGDTITSNFKVVLQQYGINIVNVPVCYLPASSLPEKLRVYPALLLKGNISALEQLVVGEVGGYKVLNPGVSAYMASSAGASPVFTYQSEAIIVNSTAPFTGIRAGEDDMRRILSQLSLSNVSRITYVTPSSVSFTLTRLPAIVFKSDYNLSKGYAFIKPLGNGYYTFREDVSGRVLEYFGVQVYEIRTPPPSYLAREGVPVGSSSLTLYILEDYHCPFCAKLMASLGDTFTRLAKSGSLKVVLVDLIVHPEVAEMHALAKCVYNKTGDGYLYFNLSRKLYDKLNQGVSTTLEDLSSIASTYTGKALIDECLKQVNAGAEHVRSLSQKLISDGYTGTPTLIFWNPEKGKGLVVPGCLDINACMTQGQLDEVLSWLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW80</accession>
    <name>A1RW80_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751725.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0050"/>
    <dbReference type="EnsemblBacteria" id="ABL77460">
        <property type="protein sequence ID" value="ABL77460"/>
        <property type="gene ID" value="Tpen_0050"/>
    </dbReference>
    <dbReference type="GeneID" id="4600784"/>
    <dbReference type="KEGG" id="tpe:Tpen_0050"/>
    <dbReference type="eggNOG" id="arCOG00727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_1_0_2"/>
    <dbReference type="OMA" id="ASVIVKW"/>
    <dbReference type="OrthoDB" id="116013at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="140" mass="16071" checksum="B742D4AF22C93A03" modified="2007-02-06" version="1">MREAVVDASVVVKWFVEEEGSDKALKVRDMYVEGEVELVAPELLVYEVLNALYYKRLFSEEEMAQVLEALEAYSFKLYPLKGEYARKALEISYRCDVTVYDASYVALAVLRDTYVYTADEKLARRLGEPYSGRVKLISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW89</accession>
    <name>A1RW89_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751734.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0059"/>
    <dbReference type="EnsemblBacteria" id="ABL77469">
        <property type="protein sequence ID" value="ABL77469"/>
        <property type="gene ID" value="Tpen_0059"/>
    </dbReference>
    <dbReference type="GeneID" id="4602144"/>
    <dbReference type="KEGG" id="tpe:Tpen_0059"/>
    <dbReference type="eggNOG" id="arCOG00695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_0_2"/>
    <dbReference type="OMA" id="ALIGKVC"/>
    <dbReference type="OrthoDB" id="40873at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="60"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="448" mass="49633" checksum="E665862C9626210D" modified="2007-02-06" version="1">MATLVIRDADTILTMNSARPVLRHQSILVDGNVVAAVGDYSSLVASYGAPDEVIDGRGKVVLPGFYDLHTHIAMAGFRGLAADAGDVIYRVFWPLERLLSGESVYRFALLGGLEALKSGVVLVADHYFFMRDVARALVELGLRGLLGHTYMDRDGPFTGERELREALDFVERWRGHELITPVLAPHAPDTVSRDNLLYFAELSREKNLFVHMHLAQTLREFKTVKEETGYTPVRYALRLGLLGGRSIVAHANYVDENEKALLAHSGSVIVQCPSTYFMSGTPFHAYDYWQLGGNVAIGTDAPCYNDNVDFFEEMRLLVYGQRMKLEKSGVWRAYDVLEMATRLSARLVGVRGGFVGKGALADLVLVNLSSVRLRPFLDPFSNIVYAASSGDVDTVIVNGRVVLKGGRHVSLDEERIVSQAEAEARMLLRRALDESPELESIIGRDKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW95</accession>
    <name>A1RW95_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751740.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0065"/>
    <dbReference type="EnsemblBacteria" id="ABL77475">
        <property type="protein sequence ID" value="ABL77475"/>
        <property type="gene ID" value="Tpen_0065"/>
    </dbReference>
    <dbReference type="GeneID" id="4600887"/>
    <dbReference type="KEGG" id="tpe:Tpen_0065"/>
    <dbReference type="eggNOG" id="arCOG04619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096758_0_0_2"/>
    <dbReference type="OMA" id="DIAPREW"/>
    <dbReference type="OrthoDB" id="135714at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="268" mass="27909" checksum="05A31BEC16F2ABC8" modified="2007-02-06" version="1">MGEDICWSGSPSPASYLGSYLRGLVPTVAVAALESSAGLLPPVLAGLSSSLAFVLKWALPGMSPVEGLLYVLGALLAILVALLDWIINVRVGLLAFSLVAFVGVEALRVVLGLSLGLGARLALLSLFSAGWVLAVDLRRRTYRYFVGYRKVGITGGLLRRVERYISGDMVSDVIVVKPLLGRLLGFGHVVPVTPSGLGLGETFSVGAAGASAFKGLAVGVGGGRIVRDIAPREWNCLYGVKNPDRVRDLILLGCAPQGRSAGAAAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE9</accession>
    <name>A1RWE9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate carboxylase subunit A</fullName>
            <ecNumber evidence="7">6.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751794.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0119"/>
    <dbReference type="EnsemblBacteria" id="ABL77529">
        <property type="protein sequence ID" value="ABL77529"/>
        <property type="gene ID" value="Tpen_0119"/>
    </dbReference>
    <dbReference type="GeneID" id="4600921"/>
    <dbReference type="KEGG" id="tpe:Tpen_0119"/>
    <dbReference type="eggNOG" id="arCOG01590">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_2"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="OrthoDB" id="36803at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="3"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="122"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="492" mass="54837" checksum="3ED2AB1CB010CA33" modified="2007-02-06" version="1">MGEIRKLLVANRGEIAVRIFRTARDLGIKTVAVYSDADKLSLHRLLADESYYLGPPEPAKSYLNAERIVKIAVSAGADAVHPGYGFLSQNPSFARMVIEEGLIWVGPKPETMKLVGDKLGARKFFSSKGIPVVPGAFEAVDFNSALSIAEEIGFPVIVKPAGGGGGIGMFVAHTPEDLEKNLEKARQLAGSAFARTEVYVEKYFPRAKHIEVQILGDKRGRVVHLFERECSVQRRYQKVVEEAPSPSLTQEEREKLLSAAVKAAEACGYENAGTFEFLFDVESRNFYFLEVNSRIQVEHPVTELVTGLDIVKLQLTVAEGGEIPFRQGEVQLRGHAIEARVYAEDPSSGFIPSPGRITYLREPAGPWVRVDSGVYEGFEVPPFYDPLLMKVVSWGQDREEARTRLLRALNELRISGVKHNKYLIVRVLEDARFRDASYTTRLLEDPAFYENLLSEDPAPDAERRIVQAQEGGEKGERTRINAWRVLARIHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ3</accession>
    <name>A1RWJ3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751838.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0163"/>
    <dbReference type="EnsemblBacteria" id="ABL77573">
        <property type="protein sequence ID" value="ABL77573"/>
        <property type="gene ID" value="Tpen_0163"/>
    </dbReference>
    <dbReference type="GeneID" id="4601272"/>
    <dbReference type="KEGG" id="tpe:Tpen_0163"/>
    <dbReference type="HOGENOM" id="CLU_2662567_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8646" checksum="32C0935E3D0E584C" modified="2007-02-06" version="1">MFSAWLTLRALHAMPLKLRIEEREEGENEESLLDRVASEVSSGKSVDPEKLWRKVFQSVGTTEVDEDGRDYQSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK1</accession>
    <name>A1RWK1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751846.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0171"/>
    <dbReference type="EnsemblBacteria" id="ABL77581">
        <property type="protein sequence ID" value="ABL77581"/>
        <property type="gene ID" value="Tpen_0171"/>
    </dbReference>
    <dbReference type="GeneID" id="4601426"/>
    <dbReference type="KEGG" id="tpe:Tpen_0171"/>
    <dbReference type="eggNOG" id="arCOG02165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815406_0_0_2"/>
    <dbReference type="OrthoDB" id="67170at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="210"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="340" mass="37916" checksum="D06A8802187FFF5D" modified="2007-02-06" version="1">MGEFVKINVRLVASLLLLLALLAPGFSRATGEAAVTGVFVTGKVTYRITGGFLLKNENNVSVNDYVYVALPQNTTFQKSYVVSINPKPLRFVVDEDGNTYAVVLVRAEPGRKYWVNVSYVVVVYSYQIDESASKGDWPPLSFVRRYTVSSGYWNVYNVTLIRLAREVAFAQTPLSTVKKLASWVEQANRGNYRVSFGRAGSDHAVTYGYRGYAITGDCVEVADVFVTMARILGVPARTAFGILLTDSERMWLNFSTIEAEGENILTHWGGHMWPQVYVEPYGWIDVDMLDGMAPNVGVYSARHILFGVEETKYYGSSLSSSAIPSYLTLEYVEYYFGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM7</accession>
    <name>A1RWM7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase, P-type (Transporting), HAD superfamily, subfamily IC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751872.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0197"/>
    <dbReference type="EnsemblBacteria" id="ABL77607">
        <property type="protein sequence ID" value="ABL77607"/>
        <property type="gene ID" value="Tpen_0197"/>
    </dbReference>
    <dbReference type="GeneID" id="4600806"/>
    <dbReference type="KEGG" id="tpe:Tpen_0197"/>
    <dbReference type="eggNOG" id="arCOG01578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_1_1_2"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="OrthoDB" id="17967at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="888" mass="96790" checksum="EB40193601C4E13C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN6</accession>
    <name>A1RWN6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0206"/>
    <dbReference type="EnsemblBacteria" id="ABL77616">
        <property type="protein sequence ID" value="ABL77616"/>
        <property type="gene ID" value="Tpen_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0206"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110881_2_1_2"/>
    <dbReference type="OMA" id="NEQNDVV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="142" mass="16138" checksum="08799091BBE6B789" modified="2007-02-06" version="1">MYNSNIETKEVKIADITPSTRRFSVTFKVLNVGDEKQITSRRDGSEHRVADVLVGDETGVALLTAWDNEIDEFRNMVGETVSLVNGYVSLYQGKLRLGLGRFGSIKPSETKIEEVNEGNNISEKEFEESYAPRRRGRGRRFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR4</accession>
    <name>RL15_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl15</name>
        <name type="ordered locus">Tpen_0234</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWR4"/>
    <dbReference type="SMR" id="A1RWR4"/>
    <dbReference type="STRING" id="368408.Tpen_0234"/>
    <dbReference type="EnsemblBacteria" id="ABL77644">
        <property type="protein sequence ID" value="ABL77644"/>
        <property type="gene ID" value="Tpen_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0234"/>
    <dbReference type="eggNOG" id="arCOG00779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000067670" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="151" mass="17021" checksum="3401E12976EA4B6F" modified="2007-02-06" version="1">MRREKKSRAYRGSRTHGWGRVGQHRKSGSRGGRGLVGYHKHKWSWTVKYAPDWYGKHGFTRHPSLVVEYRTINVGQLDAEVEEFFRKGLASREGDAYVVDLTQLGFNKLTGSGQVRNKIIVKVPVATKRAISKIEAQGGRVEVAKTQEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS5</accession>
    <name>A1RWS5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751920.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0245"/>
    <dbReference type="EnsemblBacteria" id="ABL77655">
        <property type="protein sequence ID" value="ABL77655"/>
        <property type="gene ID" value="Tpen_0245"/>
    </dbReference>
    <dbReference type="GeneID" id="4601472"/>
    <dbReference type="KEGG" id="tpe:Tpen_0245"/>
    <dbReference type="eggNOG" id="arCOG12283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922906_0_0_2"/>
    <dbReference type="OrthoDB" id="123315at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="15854" checksum="7F210C74F88BFC43" modified="2007-02-06" version="1">MDVRMIKLKKLEDLVHVLNTAQIPVVHHMSLDSRQIYFIPFILGADSSIIYFYENEKMLSGKFLLFNNFTGEITVSDKWTSDTRYTVIPIIEVDWQNVFPEKQILHELRAQTPKVKVEKERKGQAHRLIAEQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS6</accession>
    <name>A1RWS6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751921.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0246"/>
    <dbReference type="EnsemblBacteria" id="ABL77656">
        <property type="protein sequence ID" value="ABL77656"/>
        <property type="gene ID" value="Tpen_0246"/>
    </dbReference>
    <dbReference type="GeneID" id="4601473"/>
    <dbReference type="KEGG" id="tpe:Tpen_0246"/>
    <dbReference type="eggNOG" id="arCOG01123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_2"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="54988at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="345" mass="37949" checksum="E92CE67A6A73418D" modified="2007-02-06" version="1">MLNLPRTIEWVNGRVRLINQKLLPHRLEYIETSSWERVVKAIKDMEIRGAPAIGVAAAYAVALFAVNFPGENLEAFMKELERVAGVVKSARPTAVNLSWAVNRVVRVAMTATSVEEARKVILEEAVKIHREDEEANRRIGELGEQLISDGDTIITVCNAGSLATSYWGTATAPMYVAKEKGKNFRVIALETRPYLQGARLTAWELKMAGIDVVIATDNSIGILAMKEKIDLAITGADRITAQGYVANKLGTYPLALVARVHNIPFYVAAPSSSFDLNARGPEDIEIEVRSPDEVVYIAGQRITPEGVSAIYYAFDITPPQLVTGIITEKGIIYPPFEKNIRRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT0</accession>
    <name>A1RWT0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose-1-phosphate uridylyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751925.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0250"/>
    <dbReference type="EnsemblBacteria" id="ABL77660">
        <property type="protein sequence ID" value="ABL77660"/>
        <property type="gene ID" value="Tpen_0250"/>
    </dbReference>
    <dbReference type="GeneID" id="4601477"/>
    <dbReference type="KEGG" id="tpe:Tpen_0250"/>
    <dbReference type="eggNOG" id="arCOG00422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693757_0_0_2"/>
    <dbReference type="OMA" id="FHMFIDI"/>
    <dbReference type="OrthoDB" id="54369at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="264"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="397" mass="45533" checksum="00906E632467D340" modified="2007-02-06" version="1">MSIVKKMAMPYEEIPFMHWGVVSKYNFSKEKAKLIPRKRWDPLSAAEIRLVDQSTGKAYPIGKWKGHFSYISPVRSSRPGENQAPVVKDVFKDIVEGKDYAIPVTLDEKPLDSVFSVEPIMCESLRDYTSVTIVNRFPAMVRHIDPEIKETVSRLVEDKYTRIAFGINLVTFPTSYYETLSDVPLEILVSMLSSMKSAIIRAVEESRSKGFRLIPVYPFFNIGRLAGGTQPRLHSQVYIDLNEDGHGAYMESILQAFEEMRINSGCHLCTSRHEDRIVYENETWISWATSSPRRNYHVRAAPKRHVARYTDLSSSELLGLADVLRRVSRAMDRLGITRDRNVLFYSNPYGYDSFFHMFIDIIPFEHVGGIEMLDSVRVARVTPEEAAEQLRSMVEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV3</accession>
    <name>A1RWV3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Tpen_0273</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0273"/>
    <dbReference type="EnsemblBacteria" id="ABL77683">
        <property type="protein sequence ID" value="ABL77683"/>
        <property type="gene ID" value="Tpen_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0273"/>
    <dbReference type="eggNOG" id="arCOG01728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_2"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="OrthoDB" id="82745at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="287" mass="31276" checksum="62CBAE687BBE44B4" modified="2007-02-06" version="1">MVRSKRPAVHAGYFYPAEKRELIEALKNAFLHELGPGKLPEKPGSYTGNLIGVVAPHAGYIYSGHVAAHAYLALAEGGKPDVVFILGPNHHALGAPIALDENEVWETPLGDVEVDFRVSKELASREQIIRFDFQAHAYEHSIEVQVPFLQFVFGEGFTIVPISMMLQTPEAARRVGEAIAGLIMEKGLRAYVVASSDMSHYVESRIAAEKDKVAIERVLFLDAEGLYNAVIEEDISMCGPGPVMALIYIAKKLGYANVRLLKYADSGDVTGDKSSVVAYASLAFART</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ5</accession>
    <name>A1RWZ5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0316"/>
    <dbReference type="EnsemblBacteria" id="ABL77725">
        <property type="protein sequence ID" value="ABL77725"/>
        <property type="gene ID" value="Tpen_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0316"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_3_2"/>
    <dbReference type="OMA" id="HVIIPEP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="185"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="402" mass="44208" checksum="9469C966939455A0" modified="2007-02-06" version="1">MMTVDVVQSLVELVKIPSEVYYEGNRIVRRYYREAAEAVARLAETHGLRVEKVDLEGGEIPTVIASLPGKASGKPSVAFVTHYDVVPAKGPWVVEGRTMDPYSPLVLDGKVYGRGAADDKSGIVATIAGLVDIREAGIEPRYNPVVVVTGDEEVGGTGIRRLLEKGYRWDYVIIVDSGSEYVSVGASGVVHGWIKVKGKSGHAGYPHVARNAVEDLVRVLGELMELKTVRGARLSKYPSPPGSPVPYVWGRLTFNILRLPPTEPEKHNRIPGEAWCGFDMRLLPEEDVEEAVRELYAKLSSIAMKLGVSLEVEIIGKQKGWYSKNEAFVREVLTAAGRSKGREVPVAAELGGNDGTFFDEYGMDVVAFGTIREGTNIHSEGEHVYVEDIEAFRKFMYEFLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX34</accession>
    <name>A1RX34_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="7" type="ordered locus">Tpen_0355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752029.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0355"/>
    <dbReference type="EnsemblBacteria" id="ABL77764">
        <property type="protein sequence ID" value="ABL77764"/>
        <property type="gene ID" value="Tpen_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="4600893"/>
    <dbReference type="KEGG" id="tpe:Tpen_0355"/>
    <dbReference type="eggNOG" id="arCOG04129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OMA" id="KGMPHRR"/>
    <dbReference type="OrthoDB" id="107212at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="102" mass="11905" checksum="9248A9D7DC6FFD0C" modified="2007-02-06" version="1">MRHSHGYRNRGRKLLRKHPRRRGYGGLSRLMYEYNPGDRVVIDIDPTFIETAPHRRYQGRVGRVVEKRGRAYVIEVVLGSKVKKIITTKEHIKPLTTPQQSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX40</accession>
    <name>GATD_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="1">Glu-ADT subunit D</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name type="ordered locus">Tpen_0361</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752035.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX40"/>
    <dbReference type="SMR" id="A1RX40"/>
    <dbReference type="STRING" id="368408.Tpen_0361"/>
    <dbReference type="EnsemblBacteria" id="ABL77770">
        <property type="protein sequence ID" value="ABL77770"/>
        <property type="gene ID" value="Tpen_0361"/>
    </dbReference>
    <dbReference type="GeneID" id="4601490"/>
    <dbReference type="KEGG" id="tpe:Tpen_0361"/>
    <dbReference type="eggNOG" id="arCOG01924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_1_2"/>
    <dbReference type="OMA" id="RKNHTSR"/>
    <dbReference type="OrthoDB" id="61613at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000082414" description="Glutamyl-tRNA(Gln) amidotransferase subunit D">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="451" mass="49356" checksum="38B02BF3C1901C72" modified="2007-02-06" version="1">MSQGYSEKVKELLDSVGAAFFDRVKIKLADGLVLEGLLMPRPAFGDPDVVVLKLDNGYNIGISLQRIVSVELLEKFSPREAPTPGEEEGSQEDFGQPEPRVFFVGTGGTIASRVDYVTGAVYPYFTAEELYSMIPELKRLARISSETLFSIFSEDMTPSHWQQLASKIGEIFRRESDVKGVVVAHGTDTLHYSAAAMAFAVQEAPGPIVFVGAQRSSDRPSSDAALNVIGATVVAVHAPFAESVIAMHGSVNDDTILVHRGVRARKMHTSRRDAFMSINSKPIAEVDPLRGSLKLSTSTYKGRGDDVVVQASFSDKVALVKFYPGMSPDIFDFYLEKGFKGLVIEGTGLGHVSTALIDSVRRLVREGVFVAMASQCIFGRVNMNVYRTGVELIKAGVVPAGDMIPETAYVKLSWILGQTEDPEEIQRLFTANLAFEISERSEFDHYPGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX53</accession>
    <name>A1RX53_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB (TFIIB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0374"/>
    <dbReference type="EnsemblBacteria" id="ABL77783">
        <property type="protein sequence ID" value="ABL77783"/>
        <property type="gene ID" value="Tpen_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0374"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086891_0_0_2"/>
    <dbReference type="OMA" id="CFFIACK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIB" evidence="4">
        <location>
            <begin position="89"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIB" evidence="4">
        <location>
            <begin position="219"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="31380" checksum="63D53C2A60F8E247" modified="2007-02-06" version="1">MSCPNCGRKVKPILNFETGEYACPYCGYVFPESLLFTGRSARSKEEFARKVHDYPVSRGIDTTPQEISEKYKRAYYESLGKERKSASYLREVESMAKSMNLPPHLIEEVKEYFTKVQKEGLLRGRNRKAVAAAIIYYVCSKEKNVSVSLKDLEGVAGVSENDVKKAYRVLLKKGVFELGQPHVSKPSKYVYKIVGSHELQEVRSNIQLKLLADFADSLGNLLQGKKPRGIAAAAVYIIANLLGYRKTQSLIAKIAGVSTLTLRRVVKEIDENLDIYIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX58</accession>
    <name>A1RX58_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA (Guanine-N(2)-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752053.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0379"/>
    <dbReference type="EnsemblBacteria" id="ABL77788">
        <property type="protein sequence ID" value="ABL77788"/>
        <property type="gene ID" value="Tpen_0379"/>
    </dbReference>
    <dbReference type="GeneID" id="4602147"/>
    <dbReference type="KEGG" id="tpe:Tpen_0379"/>
    <dbReference type="eggNOG" id="arCOG01219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OMA" id="VFYNPVM"/>
    <dbReference type="OrthoDB" id="70865at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="384" mass="43002" checksum="636C93106285CE87" modified="2007-02-06" version="1">MEDLSTVSEGRGVFKVYPPEKYRDPAWAPVFYNPRMRCSRDISSVIVGAYAELLGRGGLVVVDAFSATGIRGIRYALENEGVGRVILNDINPRAVEIIRQNVDLNGVSDIVEVRREDASSLLASLSGVDIVDLDPFGSPAEYVDPALRCLKHKGLLCVTATDLPPLLGKYPKTCVRKYFSKSIETEFSRELAVRILLYFIAREAAKLGRTIVPLYSYYMEHHVRVCVLVLKTESRYGGLTDSIGFVKYNPTSLERAAVPLFDFYREERSDNWVVGGPLWVKEIFQRTFADAVGRAYSSKLKAHGLCGKGWRVVSTILEEVSRPPFYFTTEKFASTYRLKEEKSVVEVLEVLRARGFEGSRTHFDPKGFRTSASIGEILEAIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX92</accession>
    <name>A1RX92_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752087.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0413"/>
    <dbReference type="EnsemblBacteria" id="ABL77822">
        <property type="protein sequence ID" value="ABL77822"/>
        <property type="gene ID" value="Tpen_0413"/>
    </dbReference>
    <dbReference type="GeneID" id="4601507"/>
    <dbReference type="KEGG" id="tpe:Tpen_0413"/>
    <dbReference type="eggNOG" id="arCOG04142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="OrthoDB" id="35308at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="328" mass="36010" checksum="FD9DCC23CCF8477D" modified="2007-02-06" version="1">MEKEKIRASLLGEAVEDLRLADVSECSVKVLKSYRRLGGFSARYIVEAAELLWEAYSGGGRIAVAFPANLVATGLRGLIADSIRRGLLDLVVTTGGTFDHDIARGTGHKYYVGRFEIDDVFLKELGIHRLGNILIPVENYGPPIERFTHEMLEELSALKSSWSPSELAVESGKRLRDELSILRAVYEKGRLLVSPGVLDSAFGTAIVTFNDKARASSTARFVELDLISDERRIADYMYEAEKLAGLMLGGGISKHHLIWWAQFRGGLDYAVQITSTPEWDGSLSGARTREAVSWGKIKPEARHVTVPGDVTVILPLILGYLAHEAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX98</accession>
    <name>A1RX98_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752093.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0419"/>
    <dbReference type="REBASE" id="71889">
        <property type="entry name" value="TpeORF419P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77828">
        <property type="protein sequence ID" value="ABL77828"/>
        <property type="gene ID" value="Tpen_0419"/>
    </dbReference>
    <dbReference type="GeneID" id="4600497"/>
    <dbReference type="KEGG" id="tpe:Tpen_0419"/>
    <dbReference type="eggNOG" id="arCOG01019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140136_0_0_2"/>
    <dbReference type="OMA" id="LFKLAFK"/>
    <dbReference type="OrthoDB" id="112698at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018665">
        <property type="entry name" value="DUF2122_RecB-nuclease-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09895">
        <property type="entry name" value="DUF2122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="174" mass="18517" checksum="A1F2F29B1E191223" modified="2007-02-06" version="1">MATYTVIPVLHNTNSSQRVAEVARIAYGLGYNTLVLSRVYGPAAQVGIPEAQKLALRHNCNLIVLSDLPEVVELLRPNVILVAVPGKYGGRELSEVLKELEGKTSGGEASRIAVVFGGAEPGLSQKEMKTGELVHPDGVEEDIGSTGVAAVTLYLVARWLSLLRTRGATTREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA8</accession>
    <name>A1RXA8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsY</name>
        <name evidence="6" type="ordered locus">Tpen_0429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752103.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0429"/>
    <dbReference type="EnsemblBacteria" id="ABL77838">
        <property type="protein sequence ID" value="ABL77838"/>
        <property type="gene ID" value="Tpen_0429"/>
    </dbReference>
    <dbReference type="GeneID" id="4602108"/>
    <dbReference type="KEGG" id="tpe:Tpen_0429"/>
    <dbReference type="eggNOG" id="arCOG01227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_1_2"/>
    <dbReference type="OMA" id="AYNTIEA"/>
    <dbReference type="OrthoDB" id="90641at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="114"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="302" mass="32638" checksum="A959E6B164F42E83" modified="2007-02-06" version="1">MPKLSLGKVFSAIIEEVAYTELDEKTLKRHADAFVLRLVEAGVALEVAEALVADLSGRISGKKLGRFADKRKALLDELRALIRDVFLSAGSVDLDGLVKRGVAGKGFFSILFLGPNGHGKTTTVAKLAYRFRKQGYRVAIAAADTFRAGSIEQVSQWASRAGAEVVSLGYNADPAAVAYEAVKKGEKGDFQVVLIDTAGRMHTKKNLMDEMKKIARVASPDFKVFVGDALVGNDAVEQAKTFFSEVGFDGSILTKFDADIRGGAALSVVYVTKKPLLYVGTGQGIEDLKEFNVEEYLGMLFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD1</accession>
    <name>KAE1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kae1</name>
        <name type="ordered locus">Tpen_0452</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXD1"/>
    <dbReference type="SMR" id="A1RXD1"/>
    <dbReference type="STRING" id="368408.Tpen_0452"/>
    <dbReference type="EnsemblBacteria" id="ABL77861">
        <property type="protein sequence ID" value="ABL77861"/>
        <property type="gene ID" value="Tpen_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0452"/>
    <dbReference type="eggNOG" id="arCOG01183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_2"/>
    <dbReference type="OMA" id="MRIMCEE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022449">
        <property type="entry name" value="Kae1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000303647" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01446"/>
        </source>
    </evidence>
    <sequence length="336" mass="36300" checksum="5AEFF4F15225D97E" modified="2007-02-06" version="1">MLFGMRALKVLGIESTAHTFGVGIATSSGDILVNVNHTYVPRHGGIKPTEAAEHHSRVAPKVLSEALQKAGISVEEVDAVAVALGPGMGPCLRVGATLARYLALKFGKPLVPVNHAIAHLEISRLTTGLEDPVFVYVAGGNTMVTTFNEGRYRVFGETLDIPLGNCLDTFAREVGLGFPGVPRVEELALKGREYIPLPYTVKGQDVSYSGLLTHALSLYRSGRARLEDVCYSLVETAYSMLVEVAERALAHTGKSQLVLTGGVARSRILLEKLRRMVEDRGGVLGVVPPEYAGDNGAMIAYTGALAFSHGVRVPVEESRIQPYWRVDEVVIPWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD8</accession>
    <name>A1RXD8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752133.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77868">
        <property type="protein sequence ID" value="ABL77868"/>
        <property type="gene ID" value="Tpen_0459"/>
    </dbReference>
    <dbReference type="GeneID" id="4600986"/>
    <dbReference type="KEGG" id="tpe:Tpen_0459"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="OrthoDB" id="13967at183924"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="458" mass="52220" checksum="2B6198AD052E4914" modified="2007-02-06" version="1">MSEVMMGYGAVAEVEEFDEEFVREKLRELLGKALLHRYDFRGLEATRDKVMWELINVKANYQRYGEVYVELTNKAEVGVEKACRVSKKVIEEALEHFEELKIWRTGRTQWKVKLPGKKWRLYIHRTPAGYWVVEVVLLLKIAKLRLPDVLRLPPELLVAAQEGWVLGDASYIADCEEAIMGTSQTWQAVSFPGFWPGKEVVLYVRGIAINEKRHVSIMWQVRVKGVRNAPKVWALKKEEKRKIAIAEIEEANKGNIDEQRALRIALYYAADGKYSQNSTARVLLFAVGKEQNWVRTEGSVRIARLLYEKAPQLLEYMAASGCKKAMFLARLALIGPRKLCMSYQRLGLYAPVAGALLNLVMVAVGDEYAYIYARIPVSNAPPGWYERAVKEGWTVNVVRSGETPYYEIPQDSLFERAAEDSELWEALYAFAKAKAEVKPAAKKLVEELLKIRPAGARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ0</accession>
    <name>A1RXJ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase, RecJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752185.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0514"/>
    <dbReference type="EnsemblBacteria" id="ABL77920">
        <property type="protein sequence ID" value="ABL77920"/>
        <property type="gene ID" value="Tpen_0514"/>
    </dbReference>
    <dbReference type="GeneID" id="4601352"/>
    <dbReference type="KEGG" id="tpe:Tpen_0514"/>
    <dbReference type="eggNOG" id="arCOG00427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042622_0_0_2"/>
    <dbReference type="OMA" id="ACGAYIP"/>
    <dbReference type="OrthoDB" id="45290at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="333"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="465" mass="51309" checksum="670C96A86256C0D2" modified="2007-02-06" version="1">MARIEELTSSFAEFMSKLLESREWVLVVSHYDADGLSSLSLMLYFLWSHGVPFHARLVEQVDPRTLEELPLGEYDYAIFLDLGSGYKHLIERYAEGKNILLIDHHVPSSPKGEECCVEINPYRVGLNGSEEASASTLTYLLLRSLDEKVEKMVHVALVGALGDRLDLGPRYSFKGLNERVLREALDRKVVEASLGLRFFGGPKRPLVKAIARTTDPFLPGLTGNETACYNFLKKIGIEPKAGEELRTVGSLSSEEVKKLATELVKYMLSAGLSVKDAQKIIGYNYYLASEKPESPLRDLREYAYILNALGRMENYEVAVAINLGGRGSLLAIAEDVSNNYRKTLARLIESVLSGDSEKVKVYEGRISVIIEVRDANPKLTGPLSSILASLLSQKFRDKKLLGVAAPLSKEDSTLKISFRRLTEEVDIGRTLQDIAAKIGIEGGGHPAAGGAVVSRDKLKALLEHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ4</accession>
    <name>PYRH_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="ordered locus">Tpen_0518</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752189.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXJ4"/>
    <dbReference type="SMR" id="A1RXJ4"/>
    <dbReference type="STRING" id="368408.Tpen_0518"/>
    <dbReference type="PRIDE" id="A1RXJ4"/>
    <dbReference type="EnsemblBacteria" id="ABL77924">
        <property type="protein sequence ID" value="ABL77924"/>
        <property type="gene ID" value="Tpen_0518"/>
    </dbReference>
    <dbReference type="GeneID" id="4601356"/>
    <dbReference type="KEGG" id="tpe:Tpen_0518"/>
    <dbReference type="eggNOG" id="arCOG00858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
    <dbReference type="OMA" id="MGGTHPG"/>
    <dbReference type="OrthoDB" id="48934at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000323997" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="232" mass="25335" checksum="A7F8E93D39B8AD0F" modified="2007-02-06" version="1">MGEAALAVVKLGGSLLFEDEGSLKEGYVRGFLRELREYLAESNGRVVVVVGGGRYARNYIQLGRRLGVNEGVLDYLGILVSRLNAATMYAAFYNSPPLIPETLLDVHKLLASGLRVVFMGGLQPGQSTTTTAALVAESLNGSLIIATDVEGIYTDDPKRNPAATLMERVSVEELRRMFQREQVAGEYRMIDVLSLNVIQRSKVKVFVLKGDPPGNIFRALRGERVAGTFIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL3</accession>
    <name>A1RXL3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752208.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77943">
        <property type="protein sequence ID" value="ABL77943"/>
        <property type="gene ID" value="Tpen_0537"/>
    </dbReference>
    <dbReference type="GeneID" id="4601050"/>
    <dbReference type="KEGG" id="tpe:Tpen_0537"/>
    <dbReference type="eggNOG" id="arCOG04038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933371_0_0_2"/>
    <dbReference type="OrthoDB" id="116680at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="130" mass="14755" checksum="01C8650BFF45ED7F" modified="2007-02-06" version="1">MAPRIKIEDTSDTGEKITLTIEGPEIDETKLLQLIQALKAIKGEEQPRVIEASESMKARIWRIIVENFGDGTWFSLRDLHNVALKEMPDLKITAVSTYVSRLVAEGKLIKRGTKPNTRYRVYTSRVTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL8</accession>
    <name>A1RXL8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752213.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0542"/>
    <dbReference type="EnsemblBacteria" id="ABL77948">
        <property type="protein sequence ID" value="ABL77948"/>
        <property type="gene ID" value="Tpen_0542"/>
    </dbReference>
    <dbReference type="GeneID" id="4600499"/>
    <dbReference type="KEGG" id="tpe:Tpen_0542"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="MKSNYIS"/>
    <dbReference type="OrthoDB" id="29908at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="266"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="388" mass="42391" checksum="31DA5CE52DB8A320" modified="2007-02-06" version="1">MSDGGKRILLTGNYAAAYAARDADPDVVSAYPITPQTPVIEKIADFIASGELNAKFVRVESEHSAMAALIGAASAGARTYTATSSQGLFYMYEVVWWAAGARLPIVMGIVTRALGPPWNIWSEHSDFYAIRDSGWNMFFASSAQEVYDLTLISYGVSENPDVLLPSAVGWDAFEVSHTYEPVHVLGREEASKILPPKGAWKPPLTPEDPSSLGNLAYPEEYAEVRRTLREASEKALGVFREVATRYSRITGRNYAGLYECYRCVDADALIIGMGSIIGEVYRAVDLLRERGERVGALKLWVYRPFPYEEVARRLENVKLVVTVARASVFGSLSPLGLDVASAITLGGLDVKLVDYAAGVGGVDVYAEDVVGMYEKAKASRSGGFWWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN0</accession>
    <name>A1RXN0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0554"/>
    <dbReference type="EnsemblBacteria" id="ABL77960">
        <property type="protein sequence ID" value="ABL77960"/>
        <property type="gene ID" value="Tpen_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0554"/>
    <dbReference type="HOGENOM" id="CLU_2165396_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="12366" checksum="80CFF941F5A286C5" modified="2007-02-06" version="1">MVDAETVREVLLLAESLAAREGLVAPSVGQVVVSGEPPGSGMVKVYEGVWVDLVSESIYVEEGTLDNVVFRLLVGYFALSVYKSFGKIHWEVARDLARKHFFTVLVKLVRAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ3</accession>
    <name>DPCKG_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="1">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0578</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXQ3"/>
    <dbReference type="STRING" id="368408.Tpen_0578"/>
    <dbReference type="EnsemblBacteria" id="ABL77983">
        <property type="protein sequence ID" value="ABL77983"/>
        <property type="gene ID" value="Tpen_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0578"/>
    <dbReference type="eggNOG" id="arCOG04076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529305_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000380068" description="GTP-dependent dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <sequence length="175" mass="19952" checksum="E37620B95A4DDAF7" modified="2007-02-06" version="1">MSSSPAARRELSYSWGYLFFDEPPLSVEKAWRLVQSSRFGKTLILVGDVVSKSFRERGLGDFFIVDGHTRRNLKVEDLPGKAEAFTCKNRPGEISRECYELLRNLLTSAIGRGKKIVVYVEGEEDLLSLVALLYCPLNDSWVIYGNFRGYLEVIPCTSFFRSVAENLLVKHFEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ4</accession>
    <name>A1RXQ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752249.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0579"/>
    <dbReference type="EnsemblBacteria" id="ABL77984">
        <property type="protein sequence ID" value="ABL77984"/>
        <property type="gene ID" value="Tpen_0579"/>
    </dbReference>
    <dbReference type="GeneID" id="4600694"/>
    <dbReference type="KEGG" id="tpe:Tpen_0579"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_2_2"/>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="OrthoDB" id="97695at2157"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="17605" checksum="66F7B443B1F53FAA" modified="2007-02-06" version="1">MSERASEIKLDHIDKKILEILQDNAKTPYAQIASQLGISEATVHLRIKKLVSMGVIKRFQAIIDPEKVGRKVTAIIGVITVPQKYSQVLKELEKMPEIVEIYDVAGEYSTILKVRVKNKEDLASLLDEIGKIDGVESTKTMYVLRVIKEDTRIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ5</accession>
    <name>A1RXQ5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ordered locus">Tpen_0580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752250.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0580"/>
    <dbReference type="EnsemblBacteria" id="ABL77985">
        <property type="protein sequence ID" value="ABL77985"/>
        <property type="gene ID" value="Tpen_0580"/>
    </dbReference>
    <dbReference type="GeneID" id="4600695"/>
    <dbReference type="KEGG" id="tpe:Tpen_0580"/>
    <dbReference type="eggNOG" id="arCOG01574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_2"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="OrthoDB" id="64101at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11365">
        <property type="entry name" value="RNase_PH_archRRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="272" mass="29395" checksum="DB98C2915FFC243E" modified="2007-02-06" version="1">MAEARTFVPSVKKEVILASLAKGERLDGRKADQYREIRLEKGIIGKADGSARVFLGSTQVIAGVKLAIGTPFPDAPNEGVQIVNAELSPVASPFFEPGPPGEEDIELARVVDRGFRSAKVVDLAKLSIIPSAKCWTLYIDIYPLDHDGNLVDAAGLAALLALLDTKLPRTSVQENKIAVLDEKDPLPINTLVVYVTVAKIGEYLVVDPTLEEELTADAKITFGITERGEICAIQKSGEGSFRPDEVLRARDMALKASSTLFEAIKKAVEQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR3</accession>
    <name>A1RXR3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="7">PEP synthase</shortName>
            <ecNumber evidence="7">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0588"/>
    <dbReference type="EnsemblBacteria" id="ABL77993">
        <property type="protein sequence ID" value="ABL77993"/>
        <property type="gene ID" value="Tpen_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0588"/>
    <dbReference type="eggNOG" id="arCOG01111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_2"/>
    <dbReference type="OMA" id="LETWFFL"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="383"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="10">
        <location>
            <begin position="482"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="824" mass="92940" checksum="64AB6E863A84D259" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS1</accession>
    <name>A1RXS1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase involved in chromosome partitioning, ParA/MinD family, Mrp-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752266.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0596"/>
    <dbReference type="EnsemblBacteria" id="ABL78001">
        <property type="protein sequence ID" value="ABL78001"/>
        <property type="gene ID" value="Tpen_0596"/>
    </dbReference>
    <dbReference type="GeneID" id="4601236"/>
    <dbReference type="KEGG" id="tpe:Tpen_0596"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_2"/>
    <dbReference type="OMA" id="TRWDELD"/>
    <dbReference type="OrthoDB" id="93194at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="248" mass="26831" checksum="760B123D97636FDF" modified="2007-02-06" version="1">MYNNLLFLRTARRRLSSVKRVVVFGSGKGGVGKSVVSAATALALSEKGYRVGLLDLDVHGPSSARILKPEGRPSGSKHGIRPVNAGGVELMTVEFFLGDLPLPLSGGAKTSLVAELLMNVDWGEKDFLVVDLPPGLGDETIVPLRVLKSLAHTFLVVTSPSALSYSVVRRLLSFLVEERVNVGGLVVNYVSPVGEESYVERLEEEFGIIALARIPFDEKMEAAISERNVKLAETFFNAVRLLSEVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT4</accession>
    <name>A1RXT4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752279.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0610"/>
    <dbReference type="EnsemblBacteria" id="ABL78014">
        <property type="protein sequence ID" value="ABL78014"/>
        <property type="gene ID" value="Tpen_0610"/>
    </dbReference>
    <dbReference type="GeneID" id="4601230"/>
    <dbReference type="KEGG" id="tpe:Tpen_0610"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_2"/>
    <dbReference type="OMA" id="ATDKAPQ"/>
    <dbReference type="OrthoDB" id="90282at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="126" mass="13801" checksum="EB1A804ADFD89902" modified="2007-02-06" version="1">MVLEVVFTEKAPKPIGPYSQAVKVGSLVFVSGQIPIDPSSGEIVGKDIREQTRRVLENVKAILEATGSSLDKVVYSLVFLRNLSDFKAFNEVYEEYFKNTKPARVTVQAADIPRGALVEISVIATT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV6</accession>
    <name>GGGPS_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="1">GGGP synthase</shortName>
            <shortName evidence="1">GGGPS</shortName>
            <ecNumber evidence="1">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0633</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752301.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXV6"/>
    <dbReference type="SMR" id="A1RXV6"/>
    <dbReference type="STRING" id="368408.Tpen_0633"/>
    <dbReference type="EnsemblBacteria" id="ABL78036">
        <property type="protein sequence ID" value="ABL78036"/>
        <property type="gene ID" value="Tpen_0633"/>
    </dbReference>
    <dbReference type="GeneID" id="4601430"/>
    <dbReference type="KEGG" id="tpe:Tpen_0633"/>
    <dbReference type="eggNOG" id="arCOG01085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068610_0_0_2"/>
    <dbReference type="OMA" id="ADAIFFM"/>
    <dbReference type="OrthoDB" id="94629at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000350688" description="Geranylgeranylglyceryl phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <sequence length="255" mass="27211" checksum="E9BBCC3AF0F4DB8E" modified="2007-02-06" version="1">MRGRVKNYILEKIREHGAIHMTLIDPEKTTPEVAARIAREVAEAGTSAIMVGGSIGVSEAMTDEVVLAIKRSTEVPVILFPGSPTALSRHADAVWFLSVLNSQNPYFITGAQMQGAPIVKRYGLEVLPLGYIIVGEGGAVSIVSYTRPLPFAKPEVVAAYALAAEYMGFQFVYLEGGSGGEPVPPKIVKMVKGVTTLPLIVGGGIRSPEVAKELAKAGADIIVTGTIVEESENIRETIGRIVRATREGALERSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX1</accession>
    <name>A1RXX1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZPR1-related zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752316.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0649"/>
    <dbReference type="EnsemblBacteria" id="ABL78051">
        <property type="protein sequence ID" value="ABL78051"/>
        <property type="gene ID" value="Tpen_0649"/>
    </dbReference>
    <dbReference type="GeneID" id="4601516"/>
    <dbReference type="KEGG" id="tpe:Tpen_0649"/>
    <dbReference type="eggNOG" id="arCOG04265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107446_0_0_2"/>
    <dbReference type="OMA" id="HSAIIGD"/>
    <dbReference type="OrthoDB" id="109705at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004470">
        <property type="entry name" value="Znf_ZPR1-type_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="PTHR10876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="zf-ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00340">
        <property type="entry name" value="zpr1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zpr1" evidence="5">
        <location>
            <begin position="36"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="200" mass="22022" checksum="F5C76DFD4647D689" modified="2007-02-06" version="1">MSSQSSGEGGVEGVEQVAGDGENVTEYGRLLGEFEDVCPVCGGPLKVREVEYMLPSLGKTLLVSKKCAKCGYKRTDIVPLSFQRHTRVYLRVEKKEDLYIKVVRSPTARIFIPELGLELRPGLDAEMFVTNVEGVLQLFKDALLRLKTLDEEARVDDMVKLLDSIAEGDFTPFTLILDDVYGVSAVIAGPHSRVAIENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY2</accession>
    <name>A1RXY2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase / glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0660"/>
    <dbReference type="EnsemblBacteria" id="ABL78062">
        <property type="protein sequence ID" value="ABL78062"/>
        <property type="gene ID" value="Tpen_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0660"/>
    <dbReference type="eggNOG" id="arCOG00052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059687_0_0_2"/>
    <dbReference type="OMA" id="AWRWKNQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05017">
        <property type="entry name" value="SIS_PGI_PMI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035484">
        <property type="entry name" value="SIS_PGI/PMI_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="346" mass="38071" checksum="2450F1687B6F8676" modified="2007-02-06" version="1">MLVQAVTFPESLMHGIGAYSRLHKLLHSKIPVSPKGIVVSGMGGSFIGGLFLQDVLYSRAKVPLILLRDTYLPAFVDENYLLVAVSYSGNTEETIRVVAQATQAKVPVVAVTSGGLLQRFAEKYGLPVVSLPMGLPPRAAFPYMACALSAIVEVAIGEANLLSEIESCAENLSARRDEVFSRASESAENVKSLVEKGLTPLVYSYRPYISAGYRFKTQLNENAKIHAFYADLPEANHNEIMGWSSPLAGKFFAVLIRGREEPFYMDARISFLRELFETQGIPFLEQKPVFDAPHTCELLQLIYMLDLVSVAVALKMGVDPTPVDTITKLKKVLDARINLKEELGLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY3</accession>
    <name>EF1B_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 1-beta</fullName>
            <shortName evidence="1">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ef1b</name>
        <name type="ordered locus">Tpen_0661</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752328.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXY3"/>
    <dbReference type="SMR" id="A1RXY3"/>
    <dbReference type="STRING" id="368408.Tpen_0661"/>
    <dbReference type="EnsemblBacteria" id="ABL78063">
        <property type="protein sequence ID" value="ABL78063"/>
        <property type="gene ID" value="Tpen_0661"/>
    </dbReference>
    <dbReference type="GeneID" id="4601619"/>
    <dbReference type="KEGG" id="tpe:Tpen_0661"/>
    <dbReference type="eggNOG" id="arCOG01988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165896_1_0_2"/>
    <dbReference type="OMA" id="VMPNSPE"/>
    <dbReference type="OrthoDB" id="124073at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000366441" description="Elongation factor 1-beta">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <sequence length="91" mass="10036" checksum="7EFF4302BD9E71D4" modified="2007-02-06" version="1">MSKVAVLLRVLPDDAETKPEELYKKIAAALPEKYQVAQYQAEPIAFGLEALRMVILMPEETEGGTEELETIIQSVQGVSQVDVLNVTRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY6</accession>
    <name>A1RXY6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0664"/>
    <dbReference type="EnsemblBacteria" id="ABL78066">
        <property type="protein sequence ID" value="ABL78066"/>
        <property type="gene ID" value="Tpen_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0664"/>
    <dbReference type="eggNOG" id="arCOG07431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195722_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="80" mass="9008" checksum="CF7B228F2832D50C" modified="2007-02-06" version="1">MHYKIFLKLNCMGCGESRVMLLAYVPKTLVLGRCVRCGKKIYKGDEYYYCQGCGVSYCPICAKKTQGKCQICGKPLVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY9</accession>
    <name>A1RXY9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">top6A</name>
        <name evidence="8" type="ordered locus">Tpen_0667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752334.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0667"/>
    <dbReference type="EnsemblBacteria" id="ABL78069">
        <property type="protein sequence ID" value="ABL78069"/>
        <property type="gene ID" value="Tpen_0667"/>
    </dbReference>
    <dbReference type="GeneID" id="4601625"/>
    <dbReference type="KEGG" id="tpe:Tpen_0667"/>
    <dbReference type="eggNOG" id="arCOG04143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_1_0_2"/>
    <dbReference type="OMA" id="NWGEARF"/>
    <dbReference type="OrthoDB" id="22842at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="7">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="379" mass="43839" checksum="5D945A73BD09DD42" modified="2007-02-06" version="1">MSSQSPKGKVAAPSDSEVLAKLESLAKKLVEQMESGVPPYLVIPVRTMANTIWDRKRKLLVLGPKTARREFFDIGESKRFMQTVLMLSLIVQARREGDYPTIRELYYRGKRTIKYTDERGNKASEETWDDQRESNAVIQDIEVATGLLREHMGVTHDAKGRIVGNMIIRSKGDEIDLSKMGSGAWGIPSFVDKIEILRVEADYVLVVEKGAVFEKLNEEEFWKKNNCILVTGKGQPDRSTRRMVRRLWEEFGLPVYILTDGDSYGFYIYSVYRSGSISLSYESERLATPEARFLGVSPSDIERYELQGFTIKATERDLKRAKELMNYPWFKESKRWMEELELFLEKKEKVEIEAFAKHGLKYLSSEYIPKKIKNKQWII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY08</accession>
    <name>TMCA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="1">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcA</name>
        <name type="ordered locus">Tpen_0686</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752353.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY08"/>
    <dbReference type="SMR" id="A1RY08"/>
    <dbReference type="STRING" id="368408.Tpen_0686"/>
    <dbReference type="EnsemblBacteria" id="ABL78088">
        <property type="protein sequence ID" value="ABL78088"/>
        <property type="gene ID" value="Tpen_0686"/>
    </dbReference>
    <dbReference type="GeneID" id="4601886"/>
    <dbReference type="KEGG" id="tpe:Tpen_0686"/>
    <dbReference type="eggNOG" id="arCOG01951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_1_0_2"/>
    <dbReference type="OMA" id="NEPDDLG"/>
    <dbReference type="OrthoDB" id="2707at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000403134" description="tRNA(Met) cytidine acetyltransferase TmcA">
        <location>
            <begin position="1"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="457"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="562"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="569"/>
            <end position="575"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
    <sequence length="801" mass="91017" checksum="51B4087CCD7C384E" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY71</accession>
    <name>A1RY71_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0749"/>
    <dbReference type="EnsemblBacteria" id="ABL78151">
        <property type="protein sequence ID" value="ABL78151"/>
        <property type="gene ID" value="Tpen_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0749"/>
    <dbReference type="eggNOG" id="arCOG02713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029044_0_0_2"/>
    <dbReference type="OMA" id="MYIELFV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="270" mass="30606" checksum="95C08D41F9EBDCA4" modified="2007-02-06" version="1">MPREVLLFICRDEASKSLINAFNSELSELPKPERPKLKVKLFKLKDPSNFKSYLEQLEELYGGVYTREVKEYGIQSLPAVVVDGEKVLEGRYPSREEIRRILGLPPRPAPREERPAPIIAPEVKAPAVAAPPPERREPPKPTRVPEPIEIPVELEEPELEEHKPPPVPEEKPREQPPREAPRPVQQAPRLPPPPPAPKPEAVPARPPVAQPPRREPAQQVPAPPKPVATEDLRGTCFTCLFFDKERSRCKLLHMTVQDPYNPPCGRRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY77</accession>
    <name>A1RY77_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752422.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0755"/>
    <dbReference type="EnsemblBacteria" id="ABL78157">
        <property type="protein sequence ID" value="ABL78157"/>
        <property type="gene ID" value="Tpen_0755"/>
    </dbReference>
    <dbReference type="GeneID" id="4601076"/>
    <dbReference type="KEGG" id="tpe:Tpen_0755"/>
    <dbReference type="eggNOG" id="arCOG01291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062373_0_0_2"/>
    <dbReference type="OMA" id="CGMTIHT"/>
    <dbReference type="OrthoDB" id="58015at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="38"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="397" mass="44008" checksum="136CF32E7EB5F097" modified="2007-02-06" version="1">MSLKLSLKNLLYQKILLATKLEEALSDESKAKALSDHHARRPPRPCGFTVHSAVGCTYSCSYCYLPDMGISFREVHVYGLTGEEVSYALLKNPYFLPTRFGSQIAVGSVGEPFASPEAASKTMEYIASFEKYLGNPVQFSTKAVLDEETAGWLAQRKVPVNPLVTVVTLDKYKELEPGAPPPYERLESMRRMRKKGLRPMLFLRPLIPGVTSEEAEEILEEAKRHGAVGVVIGGLRVTPSILARLEKAGVDTGRIRGMLKGVQLTAGKQVPLPLGDLKREVLEIARSKGLVPFLSACCANNFNAYLHDGKRVPCPGLDYIDGKYCTACPVGCPSLKTEVDPDEVREIIEKFTGVKGVKVEVDDRYIRVTGGKVRLKKHHVYLIETGYRRRLRTSRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC9</accession>
    <name>A1RYC9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752474.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0808"/>
    <dbReference type="EnsemblBacteria" id="ABL78209">
        <property type="protein sequence ID" value="ABL78209"/>
        <property type="gene ID" value="Tpen_0808"/>
    </dbReference>
    <dbReference type="GeneID" id="4602139"/>
    <dbReference type="KEGG" id="tpe:Tpen_0808"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="IENGYNM"/>
    <dbReference type="OrthoDB" id="9947at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="132"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="510" mass="58299" checksum="F04C0F0C7E57D81E" modified="2007-02-06" version="1">MSQLVGLPRLEEGEVLVEYYPVTPPFAYAMIVKKRGGSLEYRLVEPPLTSDDVEKLERIKRLLLEYAPRKVDSALGALGSAPEKYLEDEVNYVIKKHKIPVPPEALDKYMYYIKRDTLGYGRIDALLRDVELEDISCDGLGTPVYVWHRRYESLPTNIVFKDPGELASLILKLSFRAGRQISVAQPIVEGSLPMGFRLHATLEEVSRRGGTFTIRKFREVPFTIVDLVAAGTVSEELAAYLWYLVENYRSVLVVGATAGGKTTTLNAIATFIRPEAKIVTIEDTPELRLPHENWVPLVTRPSHEEWVRNVDLFDLLKSAMRMRPDYLIIGEIRGEEAFTLFQAIATGHSGMSTLHAESIDYAVKRLVSEPMKVPLFLLPMMNVYILIKRLKIGDRIVRRVVSVQEALGIDESAKTVVFREVFRYNPVTARIERSGESEMLRRIAEERYIPLGDVYQEIARRKAIIETLVRNNIRRYEEVSRVVRDYYNNPEATYHQLMSGTYVFTPLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF0</accession>
    <name>A1RYF0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752495.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0829"/>
    <dbReference type="EnsemblBacteria" id="ABL78230">
        <property type="protein sequence ID" value="ABL78230"/>
        <property type="gene ID" value="Tpen_0829"/>
    </dbReference>
    <dbReference type="GeneID" id="4601832"/>
    <dbReference type="KEGG" id="tpe:Tpen_0829"/>
    <dbReference type="eggNOG" id="arCOG02245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_2_1_2"/>
    <dbReference type="OMA" id="VISPWRW"/>
    <dbReference type="OrthoDB" id="80893at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="273" mass="27954" checksum="973FD32DAB3062CA" modified="2007-02-06" version="1">MEAWQGFAIGVILGVPLAAYARRKKYLSRSAAAASVIFSGLYMAGGIGVFAASLFFFFSSSALTKLGYDLKRRMNVSEPEEGRTLMQVVGAGGVAALYSLLSALSPQSARVPLLVGAYAAIASSNADTWASELGSLSGRKPRLITNLSVEVEPGTSGGVTLLGALGSLAGSLLTGLVALIASLLGASPPLGVATIAVVVVAGWLGEVLDSVVGATLQVKYYCPRCGVLTDKKVHSCGATTVKYSGSSWVTNEVTNIIATLLSSTFSCVVAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF2</accession>
    <name>A1RYF2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752497.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78232">
        <property type="protein sequence ID" value="ABL78232"/>
        <property type="gene ID" value="Tpen_0831"/>
    </dbReference>
    <dbReference type="GeneID" id="4601834"/>
    <dbReference type="KEGG" id="tpe:Tpen_0831"/>
    <dbReference type="HOGENOM" id="CLU_975286_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="285" mass="34024" checksum="81F7C89712568986" modified="2007-02-06" version="1">MRREGARGYRILIDPAYLRKSVSRRSIEDFFSGRATLDEIVSYIEWGIDPSITARCEKNDGYRVIFYGEELVWHSLIDEEPSYPLEFYEWLRRNYRRLFKRKDPRVLDELRKLLDETIERARKEGVEHTAHRLPSDDDLASEIDEMIEETWMSYGGSDFERYPRTVEEFDSFFSKLEGWDVDITDVIIPVKAYFSAEKVVHLSEEEVKRMERSPRRFVSFLRTHLKPFVDLSEEVYVSSKSLDMLRGFFEYYLAKELKLPSNKVKLKRVLKRVLEEAVEMEELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF6</accession>
    <name>A1RYF6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752501.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0835"/>
    <dbReference type="EnsemblBacteria" id="ABL78236">
        <property type="protein sequence ID" value="ABL78236"/>
        <property type="gene ID" value="Tpen_0835"/>
    </dbReference>
    <dbReference type="GeneID" id="4601544"/>
    <dbReference type="KEGG" id="tpe:Tpen_0835"/>
    <dbReference type="eggNOG" id="arCOG07430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998852_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="12926" checksum="3AE43CFDE5B8C561" modified="2007-02-06" version="1">MKIPNPVPLLGVVVSALLLVYVPLQLVQGVTSKSIDPVFAAVGLIASLVVGGVIAFFSLVFNLAEPFVGKEDPRERRELEKRLEVYRARQRAMLEELDEIKKLLEEIRDLLKGGMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF8</accession>
    <name>A1RYF8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752503.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0837"/>
    <dbReference type="EnsemblBacteria" id="ABL78238">
        <property type="protein sequence ID" value="ABL78238"/>
        <property type="gene ID" value="Tpen_0837"/>
    </dbReference>
    <dbReference type="GeneID" id="4601546"/>
    <dbReference type="KEGG" id="tpe:Tpen_0837"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_0_2"/>
    <dbReference type="OMA" id="CEYWGMP"/>
    <dbReference type="OrthoDB" id="36379at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="258" mass="27715" checksum="86FD3099FE0DB117" modified="2007-02-06" version="1">MTGKAVRIKRLFRDGKALIVALDHGRRHGPIPGLEDLGKTLSTILQARPDAVMVTPAMIERYYGLLSEVFIVARIDGTGAVKSLDETDDRLISSVKRAVRAGADAVSVMVYPGSRNEQSLWEKLARVAEEAEDYGVPVMAEVVPKPPQFQEYGVDVVAYASRIAVELGADIVKTVYRSGFSKVTQSVPAPVVVLGGQKASLKETLTMVEKAVSEGAAGAAIGRNIFQHEDPAKATEAFMLVIHSGKSSEEALKELGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL9</accession>
    <name>A1RYL9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752564.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0898"/>
    <dbReference type="EnsemblBacteria" id="ABL78299">
        <property type="protein sequence ID" value="ABL78299"/>
        <property type="gene ID" value="Tpen_0898"/>
    </dbReference>
    <dbReference type="GeneID" id="4600475"/>
    <dbReference type="KEGG" id="tpe:Tpen_0898"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="VYTGNPF"/>
    <dbReference type="OrthoDB" id="90722at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="175" mass="20365" checksum="ACA62A52CC3E4817" modified="2007-02-06" version="1">MRRAFYPGRFQPVHLGHVKAVRWLLERVDEVIVGVTAAQYSYTPENPFTAGERIEMLRAAFREEWGRLFVVPLDNVPDNSLWLSYVASRVPSFEFVATGNEFVKLLARERGYEVLELPLWERDRLQGRVVRELMASGGEWRELVPPGVAEYLERIGAPERVRKIYLSERVKTPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN6</accession>
    <name>A1RYN6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752581.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0915"/>
    <dbReference type="EnsemblBacteria" id="ABL78316">
        <property type="protein sequence ID" value="ABL78316"/>
        <property type="gene ID" value="Tpen_0915"/>
    </dbReference>
    <dbReference type="GeneID" id="4602128"/>
    <dbReference type="KEGG" id="tpe:Tpen_0915"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958534_0_0_2"/>
    <dbReference type="OrthoDB" id="107170at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="354" mass="38572" checksum="D0D65AE6FCFEE3CA" modified="2007-02-06" version="1">MWVKEKPSFRPRPLLREALWCLANGQPLRPGEGDGDALRRMLFHVQGCREGRFRTVPSAGATYPLEVYVSSRGEVFRLERGLYRYVPCGGGLSRVGGDAGFEGFVLTAFPGRTTTYYGERGYRYVRMELGHALQNLFLSIYSHGLAGSVELVDYEFRAGSAEYVLARVAVSRPAGYCAGFALEKGLPLDDVVAARRSVRNYARASLGLEALDSIMKWSMGEVVEGARPYPKLGGGYAVEGYVVATSVKGVEKGLYRFNSSELELELVRVGEFAEKLWRAALMQGSVRKAPAVVVLTGRGPLAEVEVGAVGQNIYLNAVHEGLGTVAIGAFEDEEVSSILEVEDPLYLMPVGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP4</accession>
    <name>A1RYP4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752589.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0923"/>
    <dbReference type="EnsemblBacteria" id="ABL78324">
        <property type="protein sequence ID" value="ABL78324"/>
        <property type="gene ID" value="Tpen_0923"/>
    </dbReference>
    <dbReference type="GeneID" id="4600819"/>
    <dbReference type="KEGG" id="tpe:Tpen_0923"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="57500at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="51"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="328" mass="37370" checksum="314BF66A4993E2D1" modified="2007-02-06" version="1">MAKCYVCGRRASVYVSYLGDYLCSEHFAEYFERRFLEAVRFYKLVERGERVAVAVSGGKDSLTTLYLFSRFAGELGVEVFGVAVDEGIAGYREYKLEALRSLAGRLGVEIIVGSFKEYFGFTLDEAVKALREKGFKVKPCSVCGVLRRYVMNHAAREAGADKLATGHNLDDEVQVFVMNALKNHVEGILREGIVSERAEEGDLVPRIKPLYFIPEKEVLAYTLIRNIYTPFVECPYIVYALRHPIRHWVNEVEDSSPGFKYRVLAVKELARKTARKPSRKPSRCAVCGEPSSRPLCKTCLYRAYLDERYRRVVEEKVGKLRFSTYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ1</accession>
    <name>A1RYQ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/H associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752596.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0930"/>
    <dbReference type="EnsemblBacteria" id="ABL78331">
        <property type="protein sequence ID" value="ABL78331"/>
        <property type="gene ID" value="Tpen_0930"/>
    </dbReference>
    <dbReference type="GeneID" id="4600753"/>
    <dbReference type="KEGG" id="tpe:Tpen_0930"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="VVDEWHE"/>
    <dbReference type="OrthoDB" id="995at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="276"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="888" mass="101296" checksum="68C1CF083C0B1655" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR4</accession>
    <name>A1RYR4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752609.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0944"/>
    <dbReference type="EnsemblBacteria" id="ABL78344">
        <property type="protein sequence ID" value="ABL78344"/>
        <property type="gene ID" value="Tpen_0944"/>
    </dbReference>
    <dbReference type="GeneID" id="4601073"/>
    <dbReference type="KEGG" id="tpe:Tpen_0944"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="HCRFVNM"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="281" mass="31094" checksum="BF5CD412E954ACB3" modified="2007-02-06" version="1">MPGAGDLKYFKKLGRSLPSLGMGTWGIGGGYWSPDTSGDAEWVSALRRGLELGMTLIDTAEMYGGGHSEEVVGEAVKGFDRDEVFIVSKVWPTHARRDDVVKAAEASVRRLGTFMDLYLIHWPPAEVPLCETMRGLEEVVRRGLARFIGVSNFGLELIEEARACLSREDVAAVENKFSLLDRRDESSVVPYAEREGMLYLAYTPLEKGQLARDSFLAEVGRKYGKTAAQVALNWLIKLNPVVPIPKASSLAHVEENAGAMGWRLSDEDWRAISKRFSELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV5</accession>
    <name>A1RYV5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752650.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0985"/>
    <dbReference type="EnsemblBacteria" id="ABL78385">
        <property type="protein sequence ID" value="ABL78385"/>
        <property type="gene ID" value="Tpen_0985"/>
    </dbReference>
    <dbReference type="GeneID" id="4601961"/>
    <dbReference type="KEGG" id="tpe:Tpen_0985"/>
    <dbReference type="eggNOG" id="arCOG00871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349396_0_0_2"/>
    <dbReference type="OMA" id="YEVVWSP"/>
    <dbReference type="OrthoDB" id="11461at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="299"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="813" mass="93299" checksum="30F9C712EDF19A4C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV7</accession>
    <name>A1RYV7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Partition protein, ParA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0987"/>
    <dbReference type="EnsemblBacteria" id="ABL78387">
        <property type="protein sequence ID" value="ABL78387"/>
        <property type="gene ID" value="Tpen_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0987"/>
    <dbReference type="eggNOG" id="arCOG00586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_4_0_2"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="88555at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="33123" checksum="3DA629E4AFB95FE8" modified="2007-02-06" version="1">MKAVTFLSVKGGVGKTTLAVNTAAMLADRVGGSEKVLVVDLDAQASATVYILGHKKQRGFEESNHTVYGLLSGGVEARDCVVNVSEHTDKWSSRLYLVPGDSRVTELERRIVAESAAGGYGWLYIVRRALEKLSGEGFSYVFIDPPATLGVLSEAALAASRYFILPIVPDDFGRTSFRLFASSFFSGVAMKIRTELGTLPLCGGIVFNKVKSNTAMEKIANSIVEEVHKSKLYGKYPIPLYKTRLHEYIAYTKSLEEHVPLWNIKEKKKHENAIKEFEEYFDEFYEYVVRDKAAAGGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ0</accession>
    <name>A1RYZ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752685.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1020"/>
    <dbReference type="EnsemblBacteria" id="ABL78420">
        <property type="protein sequence ID" value="ABL78420"/>
        <property type="gene ID" value="Tpen_1020"/>
    </dbReference>
    <dbReference type="GeneID" id="4601635"/>
    <dbReference type="KEGG" id="tpe:Tpen_1020"/>
    <dbReference type="HOGENOM" id="CLU_1773300_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="17450" checksum="533D14519FA8D3C6" modified="2007-02-06" version="1">MRWVLLGEYGLRSSVFWEWLDDCFERERFETLSEMPEEEARRVYESLRRGCGKDRYSFPCELLERVHEEVSFCRLPLGYVLAVWEPFAVFVFARWGLREALLFPIFYLVTRLKLAPMEAAYLDSLARELAKELKCRDGLREDPCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ4</accession>
    <name>A1RYZ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752689.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1024"/>
    <dbReference type="EnsemblBacteria" id="ABL78424">
        <property type="protein sequence ID" value="ABL78424"/>
        <property type="gene ID" value="Tpen_1024"/>
    </dbReference>
    <dbReference type="GeneID" id="4601639"/>
    <dbReference type="KEGG" id="tpe:Tpen_1024"/>
    <dbReference type="eggNOG" id="arCOG14840">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465192_0_0_2"/>
    <dbReference type="OrthoDB" id="114761at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="189" mass="21688" checksum="A96F7410840072A3" modified="2007-02-06" version="1">MSETIVVGSETFSRRHLKVFRREELEEIFGEVAEDLARVAEATVVFSSPLSVEVEFCGNRYSLPPGITHVRGASLSVPRCTYVPEYLDEEFLEYLLFDLPRELDGARAPVVVEDMPRRFTRWAREGVLYALDILSRVARVYRVPVVVYGDEETEGLWRYARRFACIREGPERACFVDGEPCGEPHAYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ7</accession>
    <name>A1RYZ7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase D/Transphosphatidylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1027"/>
    <dbReference type="EnsemblBacteria" id="ABL78427">
        <property type="protein sequence ID" value="ABL78427"/>
        <property type="gene ID" value="Tpen_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1027"/>
    <dbReference type="eggNOG" id="arCOG02041">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122247_1_0_2"/>
    <dbReference type="OMA" id="GSHNWTD"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="184" mass="20770" checksum="A854E068DEF1C9E0" modified="2007-02-06" version="1">MSSGTIAAVLILMALAFYAGYQYAQRSLPTGVAVVSQPQCSIRVINDRDYYPTLLDYISRANKSIYIAMFQFKSDTDVISKIVELLISKNKKGVDVKVVLENTIDENELTYRRLLDNGVAVKFDSRSVTTHAKLVIIDGRYVFVGSHNWSYMAMMRNHEASVLIDCPSIAEQETQYFMNIYRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ02</accession>
    <name>A1RZ02_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752697.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1032"/>
    <dbReference type="EnsemblBacteria" id="ABL78432">
        <property type="protein sequence ID" value="ABL78432"/>
        <property type="gene ID" value="Tpen_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="4600511"/>
    <dbReference type="KEGG" id="tpe:Tpen_1032"/>
    <dbReference type="eggNOG" id="arCOG03777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680812_0_0_2"/>
    <dbReference type="OMA" id="WERVEND"/>
    <dbReference type="OrthoDB" id="30942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="404" mass="43893" checksum="8E2C021B54578554" modified="2007-02-06" version="1">MGEASKVLVAATTRDGRLVYLSAVAKPQQPGLDEALASLLKSLAYHSYEELQGDRVLLEAKKALSSQGFKVEDLELSVSFRCPSCGASINFSPETVVYVCPYCGWSGDVYGRELRVKAWPPGGREKLEEIVRGLGGVLHDAVLRYVPFWVFKVKVEGSYAGTATYTVTRTEYVTVIHEGRPRQIPTTRTEVRRKKVAGRVSFSTVKGVGARVLAEVFGGEGLKRWVEYEWENNPPPELSAEQVKPVAQSFLSAEVDAGEALGIARREIDSEIYAEIERSARRQVEGSLKEVAVESLSVDLKVVEKSLVFVPYWFFTYKVEGNLYAGAVAGPKATLLKAERRISNIERAARLAGAWIAVLASGALAQVSVGSDLGFPGVLMAWAIGLVGAYKLAESAFAPAEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ05</accession>
    <name>A1RZ05_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752700.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1035"/>
    <dbReference type="EnsemblBacteria" id="ABL78435">
        <property type="protein sequence ID" value="ABL78435"/>
        <property type="gene ID" value="Tpen_1035"/>
    </dbReference>
    <dbReference type="GeneID" id="4600940"/>
    <dbReference type="KEGG" id="tpe:Tpen_1035"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037108_1_0_2"/>
    <dbReference type="OMA" id="AEVYFVN"/>
    <dbReference type="OrthoDB" id="49089at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="6">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="325" mass="36043" checksum="591C57A498C70760" modified="2007-02-06" version="1">MPQVIEWVNPGPDDIVWRYPDENITWGAQLIVHEYEVAVFFRDGKAYDVLGPGRHTLTTQNLPLLTRVLSAIAGYPTTPFKATVIFVSTKQFRGLFGGRSQTTELAPLMFRGSYWFRVGDPKLFVTEVVGGQGKYTSAEVNEFIRGFINEKVIKHLSGYSLAEAFSSLEQVSFKTKAFLLEEVRRIGLELIDLKFEAIDTTPEYRDRLFWIKQTGAAGYVLQMDTAKEVARELGKSPGAAVGAGVVMIPPLFQPPPQQPLPQQPPAAQPPATKTCPQCGRPVPLDALFCPYCGYRFQPATKKCPNCGREVPADALYCPYCGTKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ08</accession>
    <name>A1RZ08_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-lactate permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752703.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1038"/>
    <dbReference type="EnsemblBacteria" id="ABL78438">
        <property type="protein sequence ID" value="ABL78438"/>
        <property type="gene ID" value="Tpen_1038"/>
    </dbReference>
    <dbReference type="GeneID" id="4600943"/>
    <dbReference type="KEGG" id="tpe:Tpen_1038"/>
    <dbReference type="eggNOG" id="arCOG04386">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606391_0_0_2"/>
    <dbReference type="OMA" id="MIANQLP"/>
    <dbReference type="OrthoDB" id="135190at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="450" mass="45509" checksum="5CFEFD56959F04E9" modified="2007-02-06" version="1">MSVNPVDAAVGASILLVPSLVLGVLKKDVVTASLATFATVVAAALLQSKAGAVFRAAPVGAWTGVQISLLIVAAIYFYKAYESLGYVGRLRESLTSGKGVEVFLAVYFSGFIESMSGYGVSPAVTAPILAGLGVGAVEATLLPMFGHVWAVPFASLGVPTLVLSQVTGADAESLAAFTARILFAPLVLILALALLVGRARRRAALVALASSALLPLFAVAGTMVAALTGFAGLVLGLLATQGLAATRRTLRLVSPYVMLVASVIALGALGARGLLWVALTTVAVSLAVQLAHRRFSREAAVSALSMTKRSVVAVILFSAVAEVSKQAGYTVALAEVVAVTAGKAYLPLVPVVAVLGAFITGSATNSNLLLGLLQKTFGELAGVDQSLVLALQNAGAGLGSGIAPAKISVAASTTGGKRVEAEVFRRVVPVIALLVAPLSILAVLACMAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ31</accession>
    <name>A1RZ31_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752726.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1061"/>
    <dbReference type="EnsemblBacteria" id="ABL78461">
        <property type="protein sequence ID" value="ABL78461"/>
        <property type="gene ID" value="Tpen_1061"/>
    </dbReference>
    <dbReference type="GeneID" id="4601447"/>
    <dbReference type="KEGG" id="tpe:Tpen_1061"/>
    <dbReference type="eggNOG" id="arCOG00231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="OrthoDB" id="78752at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="28421" checksum="456BBA80D9EA09FD" modified="2007-02-06" version="1">MSDPAVRTVNLNVYYGKEQVLFDVNISVPRRGIYAVMGPSGCGKSTLLRTINRLIELRPEARVKGRVEVNGLDVYRDLSPEQVARMVGMVFQTPNPLPHLSIYDNVALGPRLHGLARGRQLDAIVREALEQAALWDEVKDKLRKPATTLSGGQQQRLCIARALALKPSVLLMDEPTANLDPVNAAKIEDLVKSLSREITVIIVTHDPEQALRLASRGALLFKGRVVREGVLSSVITSSREYYDILRRLAVETPVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ33</accession>
    <name>A1RZ33_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5'-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752728.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1064"/>
    <dbReference type="EnsemblBacteria" id="ABL78463">
        <property type="protein sequence ID" value="ABL78463"/>
        <property type="gene ID" value="Tpen_1064"/>
    </dbReference>
    <dbReference type="GeneID" id="4601450"/>
    <dbReference type="KEGG" id="tpe:Tpen_1064"/>
    <dbReference type="eggNOG" id="arCOG00612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_5_0_2"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="58700at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="349" mass="36555" checksum="9501C640DDA5E19D" modified="2007-02-06" version="1">MGLFEEKIKNSELGLSFDDVLLVPKYSDVRIDEVDVSTRLTKNLLLKIPIISSPMDTVTGFEMARKLGELGGLGVLPRNIPLDAVVEYVKKISGENLPVGVAVGPFDDERVSKALDAGASIIVIDTAHGHSRNVLEATRRYAGMGAEVMAGNIVTAEAALDLIGAGAVSLRVGVGPGHACTTREVAGVGYPQLSAVAKVADAARSHGVSVVADGGIEKPADIVKALAAGADAVMLGYLLAGSDEAPGHVVVRGGECFKVYRGMGSRGALRSGSTRYGEFKRVPEGVEGLVPCRGPVEGVVEFLVNGLKQGMGYVGARNLEELRVKAEFVRLTHAGVRESGPRGLLEVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ68</accession>
    <name>A1RZ68_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1099"/>
    <dbReference type="EnsemblBacteria" id="ABL78498">
        <property type="protein sequence ID" value="ABL78498"/>
        <property type="gene ID" value="Tpen_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1099"/>
    <dbReference type="eggNOG" id="arCOG14748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078477_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="294" mass="31504" checksum="8F3144F95FC80F42" modified="2007-02-06" version="1">MAKRVLDLSGRELAKISAKDFKSSVVSSEGRTICAEVVVQSPPLVDGVSNVELAASFGADMVLLNMYDVFNPRVEGVPEEYASISDLSEFLQRFVGNNLEPVDPGVIPEGRRLSPRSIEKSIEQGSRLIVVTGNPGLGVTWSRIREGVEASKRIVGERALVFGGKMHSGGIRGEDIYDLKLIEDVLAAGADGVVVPAPYTVPGSLPERVSAVARLVYKYDALLMCAIGTSQEGSSSSVIRKIGLASKACGCDIHHIGDSGYRMGVAVPENILELSVAVRGVRHTYRRVAMSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ79</accession>
    <name>A1RZ79_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752774.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1110"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78509">
        <property type="protein sequence ID" value="ABL78509"/>
        <property type="gene ID" value="Tpen_1110"/>
    </dbReference>
    <dbReference type="GeneID" id="4601104"/>
    <dbReference type="KEGG" id="tpe:Tpen_1110"/>
    <dbReference type="eggNOG" id="arCOG05412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_2"/>
    <dbReference type="OMA" id="VEACDRK"/>
    <dbReference type="OrthoDB" id="23256at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="517" mass="58872" checksum="803787B645087677" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB3</accession>
    <name>A1RZB3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78543">
        <property type="protein sequence ID" value="ABL78543"/>
        <property type="gene ID" value="Tpen_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1145"/>
    <dbReference type="HOGENOM" id="CLU_611962_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="453" mass="48539" checksum="A06B2B5B9066F474" modified="2007-02-06" version="1">MVLVALLSLIFLFFLALPARVERGSLQAGTPTPSLKLDWRVAVVSDDPEFVSAVASSLSPRELSALPADSAGRAVGYDLVVVGWDALPRVSGDPELVLSLLRSGRVLAVSKPGEDALYQLFSRVVKPVKLGEGKTPPEDPFAFLPLIERDGYLYPGCGCEAVLVETQPRGGKLAAYYTVTRLESKQSLVYALMSVLQRSRQEATAVRLASYVSTWMRAGIGVEPAQVLGTYIGHYTSVCYDVVGPGDSIVGCTDFGLDVGLGIGTRSRSDTYRWVVEVKHHGEKTWSGFSPPVKMLGLLWVVEPSSVVVDSLTGVFPDQRLSGLEPASRSVDGQVSVFLAIPPGIFPAALHGVFQRVTWESDLDYCSSSFYGGAVACKGIWRWGLTGYDGSGSTFYLMASVAEFEALDPLYFDVAIKANGYFYSSGVMVQASSGVKLVHFRASTSTLTALGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG1</accession>
    <name>A1RZG1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted alanyl-tRNA synthetase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752856.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1193"/>
    <dbReference type="EnsemblBacteria" id="ABL78591">
        <property type="protein sequence ID" value="ABL78591"/>
        <property type="gene ID" value="Tpen_1193"/>
    </dbReference>
    <dbReference type="GeneID" id="4600385"/>
    <dbReference type="KEGG" id="tpe:Tpen_1193"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_2"/>
    <dbReference type="OMA" id="PGETKFR"/>
    <dbReference type="OrthoDB" id="60779at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="252" mass="28198" checksum="F83F1B9AA3A5217A" modified="2007-02-06" version="1">MLSLGPCPERWCPLTEELFLRDSYLRSCEATVTGVELLKGSKAYVELDRTIFHPLGGGQPSDEGSIVSPRGAFAVKKAIRDRGRIRHWGRIEAGSLEVGDTVRCELNWEKRYLVMRLHTAGHILDYAMLRLYGRLVETLDAFHGPPEAYLVYSVSEPPDAYRLEEEANKVVERGLSVAVKFVPRGELQAHIYNAPNVSRLPPSEEYRVVEIPGVNAMPCTGTHVSNTREVGRIKVLGVEREVVGVKVRYTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK3</accession>
    <name>A1RZK3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1235"/>
    <dbReference type="EnsemblBacteria" id="ABL78633">
        <property type="protein sequence ID" value="ABL78633"/>
        <property type="gene ID" value="Tpen_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1235"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_1_1_2"/>
    <dbReference type="OMA" id="MCFKQYW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="434" mass="48610" checksum="76A694594A9AFA05" modified="2007-02-06" version="1">MGRRLTVVLMGYPEGLQVEPTNECNLSCVMCVRRTWRGGAFGFMDLGLYRRLVDEGSGKLRRLALYGFGEPLLHPGFPEMVRYAREVLGDSAYILTVTNGTLMSPARAAEVFGAGIDEVAFSVDAPELDLLSRIRVGVQSYDVLGNLRSAARLKEDYGVRLGVSLVLMKSNYRRLPRVAEAAGELGLDFLVVSHVVPYSPGMVGEAVYTTASRFSVEFYEKSGQDLSVLAREAMQDEFLLHYTYASRGKRKLYLQLVDRLASSGYSVNAEIARDALSKKSLFEEVQLYLKEAARIAEEYGVEVKLPSLYADAKRRSCPYIDSNYAVVLWNGDVVPCMDLAYTHPLYTNMHYKLVRRVVFGNASREPLGEIWESPRYRAFREARRKLSDNVPWCGDCPFATSNCWYVSANEFDCYGNEVGCNECLYSAGLAHCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP8</accession>
    <name>A1RZP8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5658 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752943.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1280"/>
    <dbReference type="EnsemblBacteria" id="ABL78678">
        <property type="protein sequence ID" value="ABL78678"/>
        <property type="gene ID" value="Tpen_1280"/>
    </dbReference>
    <dbReference type="GeneID" id="4600747"/>
    <dbReference type="KEGG" id="tpe:Tpen_1280"/>
    <dbReference type="HOGENOM" id="CLU_1631744_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043717">
        <property type="entry name" value="DUF5658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18902">
        <property type="entry name" value="DUF5658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5658" evidence="3">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="162" mass="17104" checksum="59FFF2C1B6306E0F" modified="2007-02-06" version="1">MGRGLKFWVSVYAASSACDIASTYAALSTGAFYEANPNTAALLGNPLLLALREVLVILLLALLAYALRRVAGKLGLPPSASNAPVAAASAVRAAAALHNAVLLALHAKTTFSRVGGEKQTPRRAERLPASRPLLDSRTPQSLVPHRDREASGPRQSQRVEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ0</accession>
    <name>A1RZQ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752945.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1282"/>
    <dbReference type="EnsemblBacteria" id="ABL78680">
        <property type="protein sequence ID" value="ABL78680"/>
        <property type="gene ID" value="Tpen_1282"/>
    </dbReference>
    <dbReference type="GeneID" id="4600590"/>
    <dbReference type="KEGG" id="tpe:Tpen_1282"/>
    <dbReference type="HOGENOM" id="CLU_2178021_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="12346" checksum="214D82B29F921DDD" modified="2007-02-06" version="1">MRRVSPVPPRCFEAFVDAVTGALARDARSLAPLLRVRAVYAYREGEWRLAGYRLSLRVGGAFVAVRVPENTVYARAFSWRDWTLLDPEKGEALLEAVRRLYPAPRTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ6</accession>
    <name>A1RZQ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein, SSO1426 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752951.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1288"/>
    <dbReference type="EnsemblBacteria" id="ABL78686">
        <property type="protein sequence ID" value="ABL78686"/>
        <property type="gene ID" value="Tpen_1288"/>
    </dbReference>
    <dbReference type="GeneID" id="4600596"/>
    <dbReference type="KEGG" id="tpe:Tpen_1288"/>
    <dbReference type="eggNOG" id="arCOG02658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084433_0_0_2"/>
    <dbReference type="OMA" id="QYQERDG"/>
    <dbReference type="OrthoDB" id="98478at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013411">
        <property type="entry name" value="CRISPR-assoc_RAMP_TM1809"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02581">
        <property type="entry name" value="cas_cyan_RAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="307" mass="33239" checksum="EF22B64BEBB06C9A" modified="2007-02-06" version="1">MSQVPWSSHRVLLREAVFRGYLVAESPLRVGAGREAPLGSPVDLSVLRVRLGGKSVPYIPGSSLKGVFRSFSQSLAVAKGLSVCSGLSGETCMDYEDPSLGGEKLLSYLQGLMREGHSLEAVRLFHEKACLMCKVFGAPSFSGHVEFSDAYPVDEKGGVVDVSTGVRTGIAINRRTGAVYERALYQVEYVEPGARFRFEARTTNLPNYALGLLSAVIRMMNEGWVRVGGFKTRGFGEVRVEGLEFAARGATVRGSVLVKLDDYDSDVDLSGLAEARDGWLRASGDSAWKALAKLEEVWSNASFGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT2</accession>
    <name>A1RZT2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1315"/>
    <dbReference type="EnsemblBacteria" id="ABL78712">
        <property type="protein sequence ID" value="ABL78712"/>
        <property type="gene ID" value="Tpen_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1315"/>
    <dbReference type="eggNOG" id="arCOG02665">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745189_0_0_2"/>
    <dbReference type="OMA" id="YLYTARY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="371" mass="39460" checksum="371D7E8F411CC69C" modified="2007-02-06" version="1">MTLVARVLVYPVDRVRFRRTGAFDPYASGPATHASTMHYPLPSTLAGLLASIGYSRPEPPADPLEGVKALLEGQGCACRSVKLRPGYVVSRGKVYAALAGGYAELQALRRAVPEALEAYLDALEAYLEGSASRGSELLEKAGRALRGAYAEAKPEWRMGVGLERAVKVAREGYLYSAAELDLKAALGADAAVAAEILGADCASTREYAARFASDGAPVKVEVAPGQILLEELPGDEQCVALLQVTPILLPEPPRTSGPLATTTLLQQAVKSAEILLATSTLKPLFDSKTTLVTPGYSLKDGRHRDPLPGIAGNTLAIAKANPRKTYEEGAGLHSDTGWGTLIPIQLPEKLCEKAAKLREKHQQKSKNPFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT7</accession>
    <name>A1RZT7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein, Cmr4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1320"/>
    <dbReference type="EnsemblBacteria" id="ABL78717">
        <property type="protein sequence ID" value="ABL78717"/>
        <property type="gene ID" value="Tpen_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1320"/>
    <dbReference type="eggNOG" id="arCOG02657">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047795_0_0_2"/>
    <dbReference type="OMA" id="FAWITCP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="336" mass="35933" checksum="34B0B08353EC3110" modified="2007-02-06" version="1">MVFRFFSCMGVFVVSDYEYGYLLLASAYTPVHAGSGRGYGFVDLPVQRDSLGYPEVWGSSVKGALKGFLLRSVGVEAKGFFGSEPEESPTVPGLAVVTGLSLLAVPVPSVRRGIVYVTTPYLASRVAGYVDVVKRLRGFEGVESLAFPLEAFEKALVEVVEAGSSLGEGEAAASKGVAVDGAVYVSGSRVRVSRELEFPGGLDDALRSLNVLYSYKKVFGNLVVLPDGVGRSVVNGALQVVYRNRLSDATKTVERGALWSEEYLPYGSLLVGAVMVKDFEKLRGLLEAGRYEAQLRLYESAWGKLRSILGAMNGYLVVGGKETVGKGVLRVAIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU0</accession>
    <name>A1RZU0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752985.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1323"/>
    <dbReference type="EnsemblBacteria" id="ABL78720">
        <property type="protein sequence ID" value="ABL78720"/>
        <property type="gene ID" value="Tpen_1323"/>
    </dbReference>
    <dbReference type="GeneID" id="4601562"/>
    <dbReference type="KEGG" id="tpe:Tpen_1323"/>
    <dbReference type="eggNOG" id="arCOG03483">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393124_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="37"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="701" mass="76370" checksum="3A8D14FB098AFD92" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV7</accession>
    <name>A1RZV7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753002.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1340"/>
    <dbReference type="EnsemblBacteria" id="ABL78737">
        <property type="protein sequence ID" value="ABL78737"/>
        <property type="gene ID" value="Tpen_1340"/>
    </dbReference>
    <dbReference type="GeneID" id="4601315"/>
    <dbReference type="KEGG" id="tpe:Tpen_1340"/>
    <dbReference type="eggNOG" id="arCOG00824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_6_0_2"/>
    <dbReference type="OMA" id="KLFRHRF"/>
    <dbReference type="OrthoDB" id="125801at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="80" mass="8482" checksum="94C988C8BB302011" modified="2007-02-06" version="1">MKAVLRVRRKGVVILPKKLREAAGISEGDEVYAEVAGGAIVLKPLRPTVVDVDPSLVEKLLREEYELEEGAGVGGAEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW1</accession>
    <name>A1RZW1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78741">
        <property type="protein sequence ID" value="ABL78741"/>
        <property type="gene ID" value="Tpen_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1344"/>
    <dbReference type="eggNOG" id="arCOG03409">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070505_0_0_2"/>
    <dbReference type="OMA" id="IVDEFHR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="339" mass="38912" checksum="813BD105F15C4A02" modified="2007-02-06" version="1">MSFYVRFVNRVKEIDSLRSWCSSQRATPIYLYGPEGCGKTRLLKEFVSRFEEFFGEDAIAIYIDALERESLSKAFLSSKSVRIATETLLSLVERFSGLAVGRALAESIVTLVEKALTKRKLEESYILIAVDDVAKAVGLDQIELYVKWLYEAMWKLYEEYKPRAINMAVTTSEGESLNLVLRHRHSYIALLWNLDKRGFEELFEELNPPSSIDFETVWRLLGGNPGKLVELKVTYGWSIDDMIKDATARLVSVAKEVRGRGLVEQVKLIIEDPDNIWHRASVEMGEAERILLRRNLIIYKGMPTIAREDVKPDKEIGIGEYYAWQIPSYREILKKILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ0</accession>
    <name>A1RZZ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753035.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1373"/>
    <dbReference type="EnsemblBacteria" id="ABL78770">
        <property type="protein sequence ID" value="ABL78770"/>
        <property type="gene ID" value="Tpen_1373"/>
    </dbReference>
    <dbReference type="GeneID" id="4601198"/>
    <dbReference type="KEGG" id="tpe:Tpen_1373"/>
    <dbReference type="eggNOG" id="arCOG00024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_2"/>
    <dbReference type="OMA" id="RSPYLWA"/>
    <dbReference type="OrthoDB" id="27191at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="244"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="479" mass="51780" checksum="55AEED5862447F45" modified="2007-02-06" version="1">MYGVIDVGTTGVKLAVFDGELKSIHYERVELGYEPAGSGRVEQSSAEMSRVVRGFARKARSLGARRIGLSTYRASVVAWSKSGEPLTNIVTWIDGRGREVVERLPVWVKLLEALSPSLAKVLRPDTPAVLMKWLYDNVPGLREKVERGDAYLWTLDSYLVYLLTGRYASDATSSALTGLVHPRDLEPIGAVFGILSLPEAAPEIVDSVHEFGEFEGADVAVSIADQQAASVYHGLLEPGRVSGVHGTGSFVEESTPKLVVPGEGLVPVVIASLDGRRFYGAEGFLRASGLVVEWLRSAGFFSSYEEMESLASKAKPRAIVVPSFRGLRTPDAPLLKGMILGLDPSTTKADVVAGLAWGVALYVAYLLGKLSKYCGSPREPLWSGGGYSRSNAFLQALADATGLKVARPRDVESSIRGVLKLLLYSEGKASLDDLKEPPEVDAYFEPRAGSEAKTLVGELEELLEVVARWEENAFLSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1S001</accession>
    <name>A1S001_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753046.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1384"/>
    <dbReference type="EnsemblBacteria" id="ABL78781">
        <property type="protein sequence ID" value="ABL78781"/>
        <property type="gene ID" value="Tpen_1384"/>
    </dbReference>
    <dbReference type="GeneID" id="4600667"/>
    <dbReference type="KEGG" id="tpe:Tpen_1384"/>
    <dbReference type="eggNOG" id="arCOG02035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019091_0_0_2"/>
    <dbReference type="OMA" id="NPVMHHL"/>
    <dbReference type="OrthoDB" id="10685at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="618" mass="65627" checksum="F3BE2C7226DC1D30" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S019</accession>
    <name>A1S019_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1402"/>
    <dbReference type="EnsemblBacteria" id="ABL78799">
        <property type="protein sequence ID" value="ABL78799"/>
        <property type="gene ID" value="Tpen_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1402"/>
    <dbReference type="eggNOG" id="arCOG02090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505909_0_0_2"/>
    <dbReference type="OMA" id="QVECTTI"/>
    <dbReference type="OrthoDB" id="70512at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="522" mass="54241" checksum="1377E5F094928691" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1S058</accession>
    <name>A1S058_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1441"/>
    <dbReference type="EnsemblBacteria" id="ABL78838">
        <property type="protein sequence ID" value="ABL78838"/>
        <property type="gene ID" value="Tpen_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1441"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_840972_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="112"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="374" mass="41084" checksum="FBC00C793EA2A7DE" modified="2007-02-06" version="1">MLPFYLRTTVGRPLVGCFTEVPSLPFIKSKKYSCLVAGVALLEKAGYLGADVEMLVERVNEIYRKSGGAVQLTLLGEPARPYPYARFEGVVVRGPPVSESRFRAVEEVPHRELVYAVDAAARVLFDAGSFKIVSAKVAAGAWRGVERVKIFDPVKRVRVVESLDEAGDWLAEVELEAALRFAKENPGALILLDRPLFFRSGSRARRVFKALVERDWRVVGIPKSSSIRLSSGESAVGYVARLGNRLFKGLPWAYYPLLEGERLGGVGLGVGAARLSPDAAAFRVDVTWELAVRADFDYLAGMLAYLQDFTSPGYPLPLKIVHNLSRISDDELSMDRELLLEELGVGRAESAGRRLLEDSGGSEFKSKYLWGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S073</accession>
    <name>A1S073_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753118.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1456"/>
    <dbReference type="EnsemblBacteria" id="ABL78853">
        <property type="protein sequence ID" value="ABL78853"/>
        <property type="gene ID" value="Tpen_1456"/>
    </dbReference>
    <dbReference type="GeneID" id="4600582"/>
    <dbReference type="KEGG" id="tpe:Tpen_1456"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OMA" id="LNPFPKN"/>
    <dbReference type="OrthoDB" id="41678at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="6">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="7">
        <location>
            <begin position="196"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="554" mass="60268" checksum="724C243ECDCB2910" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A4</accession>
    <name>A1S0A4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753149.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1487"/>
    <dbReference type="EnsemblBacteria" id="ABL78884">
        <property type="protein sequence ID" value="ABL78884"/>
        <property type="gene ID" value="Tpen_1487"/>
    </dbReference>
    <dbReference type="GeneID" id="4601282"/>
    <dbReference type="KEGG" id="tpe:Tpen_1487"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_1_0_2"/>
    <dbReference type="OMA" id="VWAHTAN"/>
    <dbReference type="OrthoDB" id="65226at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="54"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="343"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="544" mass="60518" checksum="B7F4FE8C87AF8E78" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B0</accession>
    <name>Y1493_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase Tpen_1493</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_1493</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753155.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1S0B0"/>
    <dbReference type="SMR" id="A1S0B0"/>
    <dbReference type="STRING" id="368408.Tpen_1493"/>
    <dbReference type="EnsemblBacteria" id="ABL78890">
        <property type="protein sequence ID" value="ABL78890"/>
        <property type="gene ID" value="Tpen_1493"/>
    </dbReference>
    <dbReference type="GeneID" id="4601402"/>
    <dbReference type="KEGG" id="tpe:Tpen_1493"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_0_2"/>
    <dbReference type="OMA" id="WHGHSTW"/>
    <dbReference type="OrthoDB" id="76909at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000013516" description="UPF0173 metal-dependent hydrolase Tpen_1493">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <sequence length="228" mass="24794" checksum="B792C947CEF5AB5E" modified="2007-02-06" version="1">MARLRYLGHAAFDVELEGFDGRKRRILLDPWLENPLSPVKPSDYRGARVDYIFVTHDHGDHLGNAVELARATGAKVVAVYELAEELSKEGVQAVGANIGGPLALEGIQAVFTPALHSSSKGAPTGVVVRGRDTAVYHAGDTGLFGDMRLIGELYAPDVALLPIGGHFTMGVVEALKAVELLRPRLAIPMHYNTFPEIRADPEKFKELVEATTRTKVVVLKPGDYVEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B7</accession>
    <name>A1S0B7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753162.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1500"/>
    <dbReference type="EnsemblBacteria" id="ABL78897">
        <property type="protein sequence ID" value="ABL78897"/>
        <property type="gene ID" value="Tpen_1500"/>
    </dbReference>
    <dbReference type="GeneID" id="4601201"/>
    <dbReference type="KEGG" id="tpe:Tpen_1500"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550475_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="82" mass="9224" checksum="150B6499E8746D4E" modified="2007-02-06" version="1">MRFAAETARRTILMANGEKVLDGNTREVLTALDVLRKAAIKPPQIVQLCYELRKAGIELNALTIQEAVEEIVRAYRSRVNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C0</accession>
    <name>A1S0C0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753165.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1503"/>
    <dbReference type="EnsemblBacteria" id="ABL78900">
        <property type="protein sequence ID" value="ABL78900"/>
        <property type="gene ID" value="Tpen_1503"/>
    </dbReference>
    <dbReference type="GeneID" id="4601204"/>
    <dbReference type="KEGG" id="tpe:Tpen_1503"/>
    <dbReference type="HOGENOM" id="CLU_149108_4_1_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="91" mass="9306" checksum="45B9B89385B17634" modified="2007-02-06" version="1">MRKLEELGFSLVALGFLLAVASILALAAYSFIASPASVGFAGCVVIGFVPLCFGYGSSAGLVLALLAVALTALVALAVLAWLWLRPKGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J5</accession>
    <name>A1S0J5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1580"/>
    <dbReference type="EnsemblBacteria" id="ABL78975">
        <property type="protein sequence ID" value="ABL78975"/>
        <property type="gene ID" value="Tpen_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1580"/>
    <dbReference type="eggNOG" id="arCOG00924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="VTVFMVE"/>
    <dbReference type="OrthoDB" id="55756at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="25591" checksum="FBCBCAB7181927AC" modified="2007-02-06" version="1">MVGVLRLVDVYSGYGKMEVLHGVSFELGKGEIAAVLGPNGAGKTTMLNTIFGLATLHRGEVSFNGVKLNGRKPSEIVKLGVSYAPQLDNVFPNLTVEENLVVGAFIRGKDPGIRSDIEDILDLFPEIKRRRNQKAKTLSGGERQMLAVARALMTRPSVLLLDEPTSGLSPKAGATLMNKIKEIQQTRGVAILLVEQNVARALEIADRAAVLVGGKIVREGSADEFKSIPIERLFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L6</accession>
    <name>A1S0L6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753261.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1601"/>
    <dbReference type="EnsemblBacteria" id="ABL78996">
        <property type="protein sequence ID" value="ABL78996"/>
        <property type="gene ID" value="Tpen_1601"/>
    </dbReference>
    <dbReference type="GeneID" id="4601532"/>
    <dbReference type="KEGG" id="tpe:Tpen_1601"/>
    <dbReference type="HOGENOM" id="CLU_1700353_0_0_2"/>
    <dbReference type="OrthoDB" id="142704at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="169" mass="18554" checksum="9598E8D187270363" modified="2007-02-06" version="1">MGRAFELSYGSLFLLLALIYFLHQAVGELKEAFLHGAHPSHVLRLAVSEEGGRVVLLLFPPPVAGLRSELAEWARLAGFSLALDGTFKRVLGGIHADVSVEPLAYSLSRFLEARGYAVKAFTRRILGTTPLVELRVEEKLSRRIGNALRKLLRACKCASPSFLNSRAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M8</accession>
    <name>A1S0M8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753273.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1613"/>
    <dbReference type="EnsemblBacteria" id="ABL79008">
        <property type="protein sequence ID" value="ABL79008"/>
        <property type="gene ID" value="Tpen_1613"/>
    </dbReference>
    <dbReference type="GeneID" id="4601905"/>
    <dbReference type="KEGG" id="tpe:Tpen_1613"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_2"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="OrthoDB" id="34102at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="175"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="37548" checksum="C05103ABA3987C11" modified="2007-02-06" version="1">MRRIPGGKGVVELADGQGGVETLRLLEELFFRRVKEHLKRVEGGVGIDFPDDGALIPLPGGGFLVVTADSYTVNPPFFPGGNIGSLAVHGSINDVVMMGGRPVAMLDTIVVEEGFPMGDLEAIVNSMLEALEKEGVPLIGGDFKVMPKGQLDRITVTTVGLGVARSPIVDKPRGGDKIVVTDYVGDHGAVILMLQMGMGDVEEIASGSLKSDSKPLTPLLPVFEKFAGYIHAARDPTRGGLAGVLNEWARSGGLLAVIREEEVPVRDAVRRFAEMLGVDPLYLASEGAAVLSVSPEVAEEVVSELRGRGFPNARVIGEFRENPKYRGFVVSETGVGGHRIIEPPRGVIVPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M9</accession>
    <name>A1S0M9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753274.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1614"/>
    <dbReference type="EnsemblBacteria" id="ABL79009">
        <property type="protein sequence ID" value="ABL79009"/>
        <property type="gene ID" value="Tpen_1614"/>
    </dbReference>
    <dbReference type="GeneID" id="4601906"/>
    <dbReference type="KEGG" id="tpe:Tpen_1614"/>
    <dbReference type="eggNOG" id="arCOG04427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191173_0_0_2"/>
    <dbReference type="OMA" id="CWAVPAV"/>
    <dbReference type="OrthoDB" id="119258at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="99" mass="10561" checksum="D91C1122F7E4B559" modified="2007-02-06" version="1">MCWGTPAVVLEVSGSTARVDYGDGVVREVFVGIAGDRVSRGDIVVVHAGVIISKISPEGLREEIEFLRGILQEAGEAEDALTALRENVLALAEKLKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T0</accession>
    <name>A1S0T0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1665"/>
    <dbReference type="EnsemblBacteria" id="ABL79060">
        <property type="protein sequence ID" value="ABL79060"/>
        <property type="gene ID" value="Tpen_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1665"/>
    <dbReference type="eggNOG" id="arCOG11084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567261_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009476">
        <property type="entry name" value="DUF1097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06496">
        <property type="entry name" value="DUF1097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="183" mass="20229" checksum="50FCBA3EC4171744" modified="2007-02-06" version="1">MGREECGWVDMSVRYKVPIELTVAYLAALSLLVTLPPLGLPVWATFVTWAGYFALGADKKAFKEIYKATPLGGVFGWLAVVGFDYAVKAMPGVHYIIPVMLVEFLDVLVLMYIISVFKFTGAAVFFAFPSYFGTYYGGFYPKTGQLLLDATLALVWQVAANLLGPIFGYLSIRLSLPEKVQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T9</accession>
    <name>A1S0T9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753334.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1674"/>
    <dbReference type="EnsemblBacteria" id="ABL79069">
        <property type="protein sequence ID" value="ABL79069"/>
        <property type="gene ID" value="Tpen_1674"/>
    </dbReference>
    <dbReference type="GeneID" id="4600926"/>
    <dbReference type="KEGG" id="tpe:Tpen_1674"/>
    <dbReference type="eggNOG" id="arCOG03829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766305_0_0_2"/>
    <dbReference type="OMA" id="AVDEETW"/>
    <dbReference type="OrthoDB" id="127286at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="73" mass="8538" checksum="00423C9725A10EF3" modified="2007-02-06" version="1">MKTIAVDEATWKRLRELKDKLGFQSYNDVIRALVEQWHVSRVQESVEKLEIDVDAAEALAFFRQMKSIQKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U6</accession>
    <name>A1S0U6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase Glycosyl Hydrolase family 12</fullName>
            <ecNumber evidence="2">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1681"/>
    <dbReference type="CAZy" id="GH12">
        <property type="family name" value="Glycoside Hydrolase Family 12"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79076">
        <property type="protein sequence ID" value="ABL79076"/>
        <property type="gene ID" value="Tpen_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1681"/>
    <dbReference type="eggNOG" id="arCOG03858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854244_0_0_2"/>
    <dbReference type="OMA" id="NMGQFIE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="325" mass="35432" checksum="1705D1B37A68A6CF" modified="2007-02-06" version="1">MLLGFKTALFLLLVLVVTLAGIFITVFRLEEPQGRLTLVPCSRYAVAVADGSRVSVWKPVGAASIDPNLWGLVDFEGSGLVRGSARMECRAGGPLLIETALEVDAPLRQGVVAYHEVIYGVKPFGVDPAHPLPRDPLPLPARLDLLPRVVALAEYSVHWSSTGVNVAYDVWLKRRAGEPGVSRGDLEVMVWLYWDNATPAGSAVSRFEAPVLVNCTLKPLNWTVWIQRSIGGGWTYVAFTPSAPVRSGSVAVDLKLFLDKAVELLEESTPGQWSARDLHVVSVEFGSEVFYSKRIAVSWELRRLELLVSPSKTTAEEALRGACKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V9</accession>
    <name>A1S0V9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753354.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1694"/>
    <dbReference type="EnsemblBacteria" id="ABL79089">
        <property type="protein sequence ID" value="ABL79089"/>
        <property type="gene ID" value="Tpen_1694"/>
    </dbReference>
    <dbReference type="GeneID" id="4601017"/>
    <dbReference type="KEGG" id="tpe:Tpen_1694"/>
    <dbReference type="eggNOG" id="arCOG00727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119496_2_0_2"/>
    <dbReference type="OMA" id="YTADAEL"/>
    <dbReference type="OrthoDB" id="91957at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="147" mass="16395" checksum="3456009A0391D662" modified="2007-02-06" version="1">MGVRSVYLDTSAIVKRYVVEEGTDVLDEIYAGAYAGDVTIGFSLFNIGEVAVVFDKYRRRGVIADVNDCFSKFLSEVSTLARLGSLRVVRISKPILVESVRYVFRYGVYIADALQIASAKNFEAFLTFDERLAEVAVKEGLRLFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S139</accession>
    <name>A1S139_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1774"/>
    <dbReference type="EnsemblBacteria" id="ABL79169">
        <property type="protein sequence ID" value="ABL79169"/>
        <property type="gene ID" value="Tpen_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1774"/>
    <dbReference type="eggNOG" id="arCOG05585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462050_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="588" mass="63372" checksum="E41BFF5F51AD451C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1S154</accession>
    <name>A1S154_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753449.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1789"/>
    <dbReference type="EnsemblBacteria" id="ABL79184">
        <property type="protein sequence ID" value="ABL79184"/>
        <property type="gene ID" value="Tpen_1789"/>
    </dbReference>
    <dbReference type="GeneID" id="4601933"/>
    <dbReference type="KEGG" id="tpe:Tpen_1789"/>
    <dbReference type="eggNOG" id="arCOG02772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066585_1_0_2"/>
    <dbReference type="OMA" id="NKNCPME"/>
    <dbReference type="OrthoDB" id="65742at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="273" mass="29581" checksum="A032FBBAD1A2CD87" modified="2007-02-06" version="1">MSAAERRRVPRVVKRRKLKPLRYAFQAVSFVALVLLVPIGVLAIPAGICSIPLGSFRVDCLFGTAQRILSSPLNVALWLLLTFAAVPLLGSLLLGRFFCGLMCPVGTLLDLFGKVKRVNFLGKLRLNNKHNKYAVAASFAAASTLTGFPAFCTICPIRGLCTAYGSLKGVELALAAAPVVLEFSEKRAWCRYFCPVGAVLGAVGFRKVFGVKIDTEKCINCKACMRVCPTGAITEDSFKTGEVSRTECIMCLRCYDVCMYDALKVGVLPRAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C0</accession>
    <name>A1S1C0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1855"/>
    <dbReference type="EnsemblBacteria" id="ABL79250">
        <property type="protein sequence ID" value="ABL79250"/>
        <property type="gene ID" value="Tpen_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1855"/>
    <dbReference type="HOGENOM" id="CLU_1976649_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="126" mass="14734" checksum="5F654F830026C222" modified="2007-02-06" version="1">MVCGRLTVAREKNLEMRKAILQLWNQGFRTPRAVAERLGVPTGKVRWYMWQMRREGLLPKKDTEGDLLDKSLTLLKGALFHISSTRIDIYASNPKLADSLARAENYVREAMELIQVYRRMKWVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C5</accession>
    <name>A1S1C5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751380.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1860"/>
    <dbReference type="EnsemblBacteria" id="ABL79255">
        <property type="protein sequence ID" value="ABL79255"/>
        <property type="gene ID" value="Tpen_1860"/>
    </dbReference>
    <dbReference type="GeneID" id="4600301"/>
    <dbReference type="KEGG" id="tpe:Tpen_1860"/>
    <dbReference type="HOGENOM" id="CLU_2313940_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="99" mass="11424" checksum="D693E5098F376317" modified="2007-02-06" version="1">MSEKKCEVMSFGEWVQLYGGGVREYFEYLVLEMVRQRGEVSLTAIMDELRRQADGDKRVRAWYTPQRVVTLLAIMAKQGKIRLKLVGSKRVVEDGRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D7</accession>
    <name>A1S1D7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751392.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1872"/>
    <dbReference type="EnsemblBacteria" id="ABL79267">
        <property type="protein sequence ID" value="ABL79267"/>
        <property type="gene ID" value="Tpen_1872"/>
    </dbReference>
    <dbReference type="GeneID" id="4600343"/>
    <dbReference type="KEGG" id="tpe:Tpen_1872"/>
    <dbReference type="HOGENOM" id="CLU_1801795_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="16444" checksum="44487A18EF4FF6F6" modified="2007-02-06" version="1">MSRARIESLYRAVYERLRPFECTDNPAECLARSLLALGIPARAVEDIREAERIGGYVVVEWGGKKTKRARLSAHEWESLARLIALCRREYADLVRLLNVYKSRYPYTWKDVRVLRELAVEGRMSRDARALEAIAKVEHALAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E3</accession>
    <name>A1S1E3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751398.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1878"/>
    <dbReference type="EnsemblBacteria" id="ABL79273">
        <property type="protein sequence ID" value="ABL79273"/>
        <property type="gene ID" value="Tpen_1878"/>
    </dbReference>
    <dbReference type="GeneID" id="4600324"/>
    <dbReference type="KEGG" id="tpe:Tpen_1878"/>
    <dbReference type="HOGENOM" id="CLU_1399803_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="194" mass="22719" checksum="5D596060BFBDD474" modified="2007-02-06" version="1">MSLLDCWVNCDDRQGLCTEHAVESYRATRLAVWRGIYPCGDGGYCAGRIGEHRFRVPGTFDVWRRDGITDSTVVRRAVYVGLFRRGGKRWVKVQASRCAPVWLQRAVEEIVTEVWVYRRLSLAQALELIEGFDWGTLRPYWEKPGDEDELPCECDSSRVCYDSASEEEEEDFDDYGEEYEPIDWDEEDWEDEEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW47</accession>
    <name>DNPH1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1</fullName>
            <ecNumber evidence="2">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0017</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:57852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:26432"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="ChEBI" id="CHEBI:142209"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:51132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="ChEBI" id="CHEBI:142198"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RW47"/>
    <dbReference type="SMR" id="A1RW47"/>
    <dbReference type="STRING" id="368408.Tpen_0017"/>
    <dbReference type="EnsemblBacteria" id="ABL77427">
        <property type="protein sequence ID" value="ABL77427"/>
        <property type="gene ID" value="Tpen_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0017"/>
    <dbReference type="eggNOG" id="arCOG02435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100069_1_0_2"/>
    <dbReference type="OMA" id="MHIYFCG"/>
    <dbReference type="OrthoDB" id="112007at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070694">
        <property type="term" value="F:deoxyribonucleoside 5'-monophosphate N-glycosidase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03036">
        <property type="entry name" value="Nuc_phosphate_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028607">
        <property type="entry name" value="DNPH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000379469" description="Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O35820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03036"/>
        </source>
    </evidence>
    <sequence length="143" mass="16043" checksum="7C484EE6309BC0CB" modified="2007-02-06" version="1">MKVYLAAPMRGDRSALANVKKLLQALEERGYVVLTKHVADDVLDVEKGMTPREVFERDIRLLEEADVLVAEVSYPSLGVGFEIAYFLLRGKPVIALALRERLESVSAMIRGITWENFRLVAYSDVDEAIEKLDSMLPGSVDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW60</accession>
    <name>A1RW60_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751705.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0030"/>
    <dbReference type="EnsemblBacteria" id="ABL77440">
        <property type="protein sequence ID" value="ABL77440"/>
        <property type="gene ID" value="Tpen_0030"/>
    </dbReference>
    <dbReference type="GeneID" id="4601339"/>
    <dbReference type="KEGG" id="tpe:Tpen_0030"/>
    <dbReference type="HOGENOM" id="CLU_2140334_0_0_2"/>
    <dbReference type="OrthoDB" id="131279at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="13371" checksum="6A9BC697820FF729" modified="2007-02-06" version="1">MRDGVRFSLLEDFKQLPAALQRQPRGERWDLLVVDEFMTAEIVSTGDALLLAMYAEVEAPAGPIPQPTDPDITLVPEGGTLKLKAFTRYPMQGTLIYHSIIKKINEFRRTLAALLAVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW74</accession>
    <name>A1RW74_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase U62, modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751719.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0044"/>
    <dbReference type="EnsemblBacteria" id="ABL77454">
        <property type="protein sequence ID" value="ABL77454"/>
        <property type="gene ID" value="Tpen_0044"/>
    </dbReference>
    <dbReference type="GeneID" id="4600465"/>
    <dbReference type="KEGG" id="tpe:Tpen_0044"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_2"/>
    <dbReference type="OMA" id="RGMASRC"/>
    <dbReference type="OrthoDB" id="49762at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="2">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="230"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="442" mass="47447" checksum="8ECE65D2E961CDA0" modified="2007-02-06" version="1">MIGEIPYLAEWLVKRALELGADEAEASFSVYRERSVKSEGAYPKALSRASVDVWIRVAKGKRVAIVTATSLDRDVLSEILERGVAMARVAEEDPHWGGLPDPEGPTHGWVGFDEGVATLGADWLIAAVRELAEEVRGRFPDVKVTGSGASAASGYSYVYNSRGLRAEDRGTSMGVYLSTKASHAGGEGTGFAFIHSRSMVAELEGLAERASRLALDAARGEKLGSSVTGNVLFKPYPLAELLDYLLVPALNAMNVLEGLSPLRDKVGEKVLGEMTLLDDGTLPGGIETSLFDAEGVPRRRTLLVERGVLRGYLHNTYTARRMSTKSTGNAGRARGSYTVSRSNMVVEGGDESEEELARDAAVVVDGSLLSVHTVNYVTGNFSVVATNPYLVKNGELKPLKPVTIAGNIYQSAPTLRFSRTPRNTYTGFYLPETLVGKVTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD0</accession>
    <name>A1RWD0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, zinc-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751775.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0100"/>
    <dbReference type="EnsemblBacteria" id="ABL77510">
        <property type="protein sequence ID" value="ABL77510"/>
        <property type="gene ID" value="Tpen_0100"/>
    </dbReference>
    <dbReference type="GeneID" id="4601252"/>
    <dbReference type="KEGG" id="tpe:Tpen_0100"/>
    <dbReference type="eggNOG" id="arCOG00458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108521_2_0_2"/>
    <dbReference type="OMA" id="KDRGQYH"/>
    <dbReference type="OrthoDB" id="72411at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
        <property type="entry name" value="Pept_M54_archaemetzncn_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="186" mass="21325" checksum="6CC51A1E86DA40DD" modified="2007-02-06" version="1">MAEYLVRLYPVNIAPERVEWLKEQLTRIFNAEVLVDTKTVGFGTVLRFFDEERDQVNAEYLLEELKNRIGVTPSQRALVVIGADGYVEGLNFVFGVANDGWGGIVFTERLNPEFYGEQFSEELFRARLLKEAIHELGHSFGLGHCRQNCVMRFSNSVYDVDSKPPFFCKRCSAAISRYYPGLLRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD4</accession>
    <name>A1RWD4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751779.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0104"/>
    <dbReference type="EnsemblBacteria" id="ABL77514">
        <property type="protein sequence ID" value="ABL77514"/>
        <property type="gene ID" value="Tpen_0104"/>
    </dbReference>
    <dbReference type="GeneID" id="4600476"/>
    <dbReference type="KEGG" id="tpe:Tpen_0104"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299490_0_0_2"/>
    <dbReference type="OrthoDB" id="120411at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13463">
        <property type="entry name" value="HTH_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="100" mass="11307" checksum="1705C8E5AB096B0C" modified="2007-02-06" version="1">MVGKQSFDRKVIFTEADLILLSLLNGEKKISDLRQAASLSTTSIYNNINKLLEWGLIEDDRVGSPGNRIIRLTEKGLRVARILKMLEDELTPKVVELKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD8</accession>
    <name>A1RWD8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751783.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0108"/>
    <dbReference type="EnsemblBacteria" id="ABL77518">
        <property type="protein sequence ID" value="ABL77518"/>
        <property type="gene ID" value="Tpen_0108"/>
    </dbReference>
    <dbReference type="GeneID" id="4601011"/>
    <dbReference type="KEGG" id="tpe:Tpen_0108"/>
    <dbReference type="eggNOG" id="arCOG05487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111004_0_0_2"/>
    <dbReference type="OMA" id="REFVFRD"/>
    <dbReference type="OrthoDB" id="110641at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="219" mass="25636" checksum="10F1AB63D58354BD" modified="2007-02-06" version="1">MDWMSGELEKQYRALLRVYLYRSFGNLSEQEAEYMLEVAYADFLNYIAVERDVIFEEGYEGAVLMILRDMYLNNEMELDKTLSEWFEVWAWKWRQRVKLALKEEEESKLASEVENKVQALLPKVSKLYEWAKRYAIGSLVRHGEVCFTNLLAETVVKEVFFKVASSEEPEKAAKFLSENPAFIISEIAKRVKELSAFKGNLVVVRLNPLFFESQRGENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE0</accession>
    <name>A1RWE0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0110"/>
    <dbReference type="EnsemblBacteria" id="ABL77520">
        <property type="protein sequence ID" value="ABL77520"/>
        <property type="gene ID" value="Tpen_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0110"/>
    <dbReference type="eggNOG" id="arCOG00118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_2"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="406" mass="45299" checksum="7967597E2634F03E" modified="2007-02-06" version="1">MEIPAIEGGKPVREKFKEYYPTFTEREKSLVLDALSSGRLVYSSGSYVKRFEEEFARYVGVRHAVATINGTAALHTAVASLGIGPGDEVITTPFSFVATATAILHHNAIPVFGDIELESLNLDPETIVDKITSRTKAILVVHLAGYPAEMDEILKIAREHGLYVIEDCAQAIGSEYRGRKVGGIGDVGAFSFYQTKNMTTGEGGMVTTNRDDVYAYARMFVDQGQEAKYYHSILGWNYRMTELQGALGLGQLERVDQLNENRARIAKVYLDELQGLDGDLVLLPKVRPYVKHTWHIFQVLLNLEKLRVDRDRVLEALRAENVLALVAYPRVIYENPLFQRMIGYGKGCPWKCPFYGGSVSYRKGLAPKAEMAARSVITLPTLAGMDEEDAIDTAKALKKVLLYYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE1</accession>
    <name>A1RWE1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751786.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0111"/>
    <dbReference type="EnsemblBacteria" id="ABL77521">
        <property type="protein sequence ID" value="ABL77521"/>
        <property type="gene ID" value="Tpen_0111"/>
    </dbReference>
    <dbReference type="GeneID" id="4600997"/>
    <dbReference type="KEGG" id="tpe:Tpen_0111"/>
    <dbReference type="eggNOG" id="arCOG04230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068640_0_0_2"/>
    <dbReference type="OMA" id="LHAILCH"/>
    <dbReference type="OrthoDB" id="51434at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039967">
        <property type="entry name" value="MJ1020-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40517">
        <property type="entry name" value="PTHR40517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="267" mass="29749" checksum="FB0E0B1FE8CCE3F7" modified="2007-02-06" version="1">MCEGKTLVSKSIIEKWKKADAFVARLVDYLESDEEVAALLEMSNINAVQRLGYNDHGPVHARIVAGTSLEILSMLTRSSVELSSLKHGTARSLDEVKFILVAASYLHDIGNSIHREYHEATGSLLAKDIVDRALRYTFPEMETRRRVFLRQEVLSAIFSTEMNTKPLTVEASIVKLADGLDMSEGRARLSYKLGKIDMHSLSALNVKRVELTCSEQVPIVVEVYMGDMAGFFQVERVLLPKLESSKLKGMVRIDIFDGSGRKVASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH9</accession>
    <name>A1RWH9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solute binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0149"/>
    <dbReference type="EnsemblBacteria" id="ABL77559">
        <property type="protein sequence ID" value="ABL77559"/>
        <property type="gene ID" value="Tpen_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0149"/>
    <dbReference type="eggNOG" id="arCOG01672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_1_0_2"/>
    <dbReference type="OMA" id="LYTGGWI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="32"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="895" mass="99782" checksum="E6E29D95472265F5" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL0</accession>
    <name>A1RWL0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0180"/>
    <dbReference type="EnsemblBacteria" id="ABL77590">
        <property type="protein sequence ID" value="ABL77590"/>
        <property type="gene ID" value="Tpen_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0180"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_0_1_2"/>
    <dbReference type="OMA" id="ICILMYP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="115"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="457" mass="48982" checksum="B981FAFB3FC75CE5" modified="2007-02-06" version="1">MFAFTRRKAFEVAVAGSLVALAGVVCNAALYLSSQMRPSQYVLAYYNGLALGFVNDSLSVLVSLMVALNGLATIVFSKHYMSPSNREHPVSLEETPRYYGWLLLFEASALGFVYSSTLLSMVAFFELTSLCSYALISYYEDPESRRSGLQAFIVTHIAALGLYLAAGLTYASTGSVEVVALKGMPEELKTIAELLLLVAAAGKSAQIPFHRWLPDAMVAPTPVSAYLHAAAMVKLGAYLMLRVLVDAGYTHTVALACLAVGVVSMAYGCAMYFPQLDMKRLLAYSTITQLSYIFMGAGLASLGSAMALKGAELHIFTHGFAKELFFLVAGLISFSAGTRMLDKISGLRAARTAAVGFTVAALSVTGVPPFGLFWSKILLILGGYSAGSIVAAIIATAMLCESIVCFAWFLRVFTKCVGGEPSDAVKSMQREPTTMKMTVYFLALMSLLAPFLATPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN7</accession>
    <name>A1RWN7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxypyruvate reductase</fullName>
            <ecNumber evidence="3">1.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.81" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0207"/>
    <dbReference type="EnsemblBacteria" id="ABL77617">
        <property type="protein sequence ID" value="ABL77617"/>
        <property type="gene ID" value="Tpen_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0207"/>
    <dbReference type="eggNOG" id="arCOG04170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
    <dbReference type="OMA" id="GKAAWRM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="342"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="459" mass="48427" checksum="3CFB1EE427F189F4" modified="2007-02-06" version="1">MKHRSLVSEASEHARMVAVTLALEGVAVADPAKAVENYVRLEGDELVLRDGTRVGLRGRVIVVGAGKATGGMAVGIEKVLGDRISGGVISVPEDLVESVSKQLSRIQVVGATHPRASRKSVEAGERIVSTVRGLREEDTVIALFSGGGSALAELPAEGVDIEELGELSVKLMKAGADIVELNTVRKHLSRFKGGWLAKHAYPAAVVALLISDVVGDRMDTIASGPTVPDPTTYQDAVAVIRKYRLEDSLPQSIRRILEDGLKGLAPETPKPGDPAFSRVHNRIIASNTLSLNAMAEKAKAMGYNTVILTSLLEGEAREVAKVLAAIAKEVLKTGNPVSPPAVILAGGETTVTVKGKGLGGRNQELALSAAIALKGVDRVALVSIGSDGRDGPTDVAGAVVDGYTYQRALAKGVRPEEYLENNDSYNFFRVVGGHVKTGYTGTNVNDFVVIVVEKENPWE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ5</accession>
    <name>RS19_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps19</name>
        <name type="ordered locus">Tpen_0225</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWQ5"/>
    <dbReference type="SMR" id="A1RWQ5"/>
    <dbReference type="STRING" id="368408.Tpen_0225"/>
    <dbReference type="EnsemblBacteria" id="ABL77635">
        <property type="protein sequence ID" value="ABL77635"/>
        <property type="gene ID" value="Tpen_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0225"/>
    <dbReference type="eggNOG" id="arCOG04099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_2"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000051141" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="141" mass="16166" checksum="2E7BF9AFD20FDD58" modified="2007-02-06" version="1">MESTSKFTYRGYTLEELRQMPIEKLAEIMPARQRRSLLRVFKQGTSEEHLKLLEKIRRAAKLASEGKKQPVIKTHLRDFIILPEMVGLTIHVHNGKEFVPVEITPEKIGHYLGEFALTTKKVEHGEPGLKATRSSMFVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR8</accession>
    <name>A1RWR8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl19e</name>
        <name evidence="8" type="ordered locus">Tpen_0238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751913.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0238"/>
    <dbReference type="EnsemblBacteria" id="ABL77648">
        <property type="protein sequence ID" value="ABL77648"/>
        <property type="gene ID" value="Tpen_0238"/>
    </dbReference>
    <dbReference type="GeneID" id="4600708"/>
    <dbReference type="KEGG" id="tpe:Tpen_0238"/>
    <dbReference type="eggNOG" id="arCOG04089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="109335at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="7">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="155" mass="17949" checksum="A0A09842F9CD30E1" modified="2007-02-06" version="1">MDVSLARRLASEVLGVGESRIWIDPDKLDEVSAAISRSDVRRLIKDGVIRVLPPSTPSRGRVRERRLKRKKGRGRGPGSKKGPRVDEKRAWINRVRAQRRYLKFLKEKGQIDTKTFRYLYRLVKGGMFRSLSHLKLYISEHKLVRVEEGGERSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU9</accession>
    <name>A1RWU9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="10" type="ordered locus">Tpen_0269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751944.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0269"/>
    <dbReference type="EnsemblBacteria" id="ABL77679">
        <property type="protein sequence ID" value="ABL77679"/>
        <property type="gene ID" value="Tpen_0269"/>
    </dbReference>
    <dbReference type="GeneID" id="4601890"/>
    <dbReference type="KEGG" id="tpe:Tpen_0269"/>
    <dbReference type="eggNOG" id="arCOG04246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_2"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="22545at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="379"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="482" mass="53003" checksum="0CA9ADC481B87F82" modified="2007-02-06" version="1">MAPPLRRITEYLWEIPEKYKPGMNVPGLVIADEVLISKMKEDLTLEQVANVAMLPGIYKYSIVLPDGHQGYGFPIGGVAAFDAEKGVLSPGGVGYDINCGVRVLSTNLTEQEVRPKLRELAETLFRKIPSGLGSTSGLRLSHAELDRVLEEGVEWAIERGYGWREDMEHIEEKGRMEGADADAVSNEAKQRGSNQLGTLGSGNHFLEVQRVDKIYDPEVAKVFGIEREGQVTVMIHTGSRGLGHQVASDYLKIMERVVRKYNMPLPDRELVSVPATSPEAERYFAAMKAAANFAWTNRQVITHWVRESFRAVFKTDPDKLGLNVIYDVAHNIAKLEEHVVDGKRVKVYVHRKGATRAFPPGHPEIPADYKSIGQPVLIPGSMGTASYILVGTQKAMDLTFGSSPHGAGRMQSRAEARRSVRGQEIKSELESRGIVVRAASLAVVAEEAPDAYKDVDRVVMVADAVGIARKIVRMTPIAVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ3</accession>
    <name>A1RWZ3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0314"/>
    <dbReference type="EnsemblBacteria" id="ABL77723">
        <property type="protein sequence ID" value="ABL77723"/>
        <property type="gene ID" value="Tpen_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0314"/>
    <dbReference type="eggNOG" id="arCOG00534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_2_2_2"/>
    <dbReference type="OMA" id="HERKSCC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="125" mass="14162" checksum="1B92A1EF676FC6DF" modified="2007-02-06" version="1">MGAVAVFIGRVKGRIEGRRVESLMYEVVEPSSSQSLERIAREELEKNNLLAVSIHHKKGVAVPGEPVLFIAVASKSREEAVSGLRSTLERVKHEAYVWKLEKREDGEYWIIGDRKRVPRRPRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX01</accession>
    <name>A1RX01_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751996.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77731">
        <property type="protein sequence ID" value="ABL77731"/>
        <property type="gene ID" value="Tpen_0322"/>
    </dbReference>
    <dbReference type="GeneID" id="4600973"/>
    <dbReference type="KEGG" id="tpe:Tpen_0322"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="OrthoDB" id="144493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="485" mass="54823" checksum="745E6B09A3630899" modified="2007-02-06" version="1">MVGENVMGDEEVERKVREETWRRAALSLYATRTEDKRKARGGRKGRVHYRGLFDTVSTINWDFTRFVAHALTVVPDDVYPRFGKLFDYDLRQYLLLGDDNRPREGSAVVELRDRLQAIVDATEDGLRAEKKGKVWHVYIPRENWHVIAHKPTYDWIVHVPLEGFWTETSFPEVLARTSPDVLRSLQRGWILTDVTPPHGRYSDIKFGTTQSWQLPSTLATFPSDHVDIGVTAGILGSTGLSIKWEVSIHGYADELGWASGLVGATKRAEFRALVERCKELNGDSVALATAFLGDGELEFFLRLRWLYFKVGQEHIYLPAESAIANARAAVERAWEYVAFVGKVTRCAKIRHWLYVAYGAPGRRGRKPGQNGQRLDLYAPVAGALLNLVLIGHGDYARIYARMPVDGAPPGWYERVVEEGWVVRVVRNAGMLYYQVPQDSLFEHAAEDATLWEALYRFAAAKAQAKPAAKKLVEELLKIRLAGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX12</accession>
    <name>A1RX12_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752007.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0333"/>
    <dbReference type="EnsemblBacteria" id="ABL77742">
        <property type="protein sequence ID" value="ABL77742"/>
        <property type="gene ID" value="Tpen_0333"/>
    </dbReference>
    <dbReference type="GeneID" id="4601700"/>
    <dbReference type="KEGG" id="tpe:Tpen_0333"/>
    <dbReference type="eggNOG" id="arCOG07440">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184938_0_0_2"/>
    <dbReference type="OMA" id="CPNFQSR"/>
    <dbReference type="OrthoDB" id="113539at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="82" mass="9793" checksum="868468F4E0AFB5AB" modified="2007-02-06" version="1">MTHQDYKYELEVIKLEKPMKVDEKLLEDLKNARISRKMISEMKKEAVQCPILGRQVSFLQCYNCKNFVRRVRGRVFCRGDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX50</accession>
    <name>A1RX50_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752045.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0371"/>
    <dbReference type="EnsemblBacteria" id="ABL77780">
        <property type="protein sequence ID" value="ABL77780"/>
        <property type="gene ID" value="Tpen_0371"/>
    </dbReference>
    <dbReference type="GeneID" id="4600771"/>
    <dbReference type="KEGG" id="tpe:Tpen_0371"/>
    <dbReference type="eggNOG" id="arCOG01225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OMA" id="CFEYLLQ"/>
    <dbReference type="OrthoDB" id="86220at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="262" mass="29660" checksum="C070550107B7D744" modified="2007-02-06" version="1">MVKYLVVFIVGPAGSGKSTFTSSFKDWLLSQSTPASTINLDPAVEYLDYDPDIDIREYVFVRDVIEKYNLGPNGAIIASVDLAVEHLDKVQAAMEDLPEGYVLVDTPGQMEIFAYRQSGTYIVSELCSSSSLCAAVFMVDASIATQPYNFLSQLFLSASMYYRLRLPLTVAVNKIDVLEDMEKNRLLNWLSDVESMENELEFASNVDRVFTKRVLRLLSDFMEVVPFVPVSAKTKENFEQVYFYLQQIYRGGEDFERDASEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF3</accession>
    <name>IF6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 6</fullName>
            <shortName evidence="1">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eif6</name>
        <name type="ordered locus">Tpen_0474</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752148.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXF3"/>
    <dbReference type="SMR" id="A1RXF3"/>
    <dbReference type="STRING" id="368408.Tpen_0474"/>
    <dbReference type="EnsemblBacteria" id="ABL77883">
        <property type="protein sequence ID" value="ABL77883"/>
        <property type="gene ID" value="Tpen_0474"/>
    </dbReference>
    <dbReference type="GeneID" id="4602033"/>
    <dbReference type="KEGG" id="tpe:Tpen_0474"/>
    <dbReference type="eggNOG" id="arCOG04176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OMA" id="GEDTTGP"/>
    <dbReference type="OrthoDB" id="70525at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000002605" description="Translation initiation factor 6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <sequence length="223" mass="23959" checksum="D492A728FF6FD163" modified="2007-02-06" version="1">MVNVEAISLYGTPNIGVYIFANDRFALIPYDAPEKLDRKIAENLSVDAFRVSVAGTRLVGIFLAGNNNGLVVPRVILDSELEHLKSLLDVNIVVLEDVRETGIGNLVLANDNGCVASQILPKSAVDRIADALGVECIQMSIGDVPFVGSLSVATNRGVALPPLATEEEIKSVEEALKVKANVLTVNRGKMFLRTGLVANSKGALVGEDTTGHEMMQLQRIFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF8</accession>
    <name>A1RXF8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hexulose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0479"/>
    <dbReference type="EnsemblBacteria" id="ABL77888">
        <property type="protein sequence ID" value="ABL77888"/>
        <property type="gene ID" value="Tpen_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0479"/>
    <dbReference type="eggNOG" id="arCOG00068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094236_1_0_2"/>
    <dbReference type="OMA" id="KTIQPMG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="35"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="21459" checksum="521B493D35DFE35A" modified="2007-02-06" version="1">MSEDVSKAMVSIASYIEKVAGELDKESVNRFLKILTSALATKSKILVVGAGRSGLVAKAFAMRLMHLGFNVYVVGETITPSISEGDVLIAVSGSGSTQVVLSVASAAKRAKAVVVAITSFAESPLGKISDHIVVVPGRTKVAAETDYFARQVLGMYEPLAPLGTLFEDTVMVFFDGVIYALMNILGVGEEDMKKRHANVEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG0</accession>
    <name>A1RXG0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752155.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77890">
        <property type="protein sequence ID" value="ABL77890"/>
        <property type="gene ID" value="Tpen_0481"/>
    </dbReference>
    <dbReference type="GeneID" id="4601875"/>
    <dbReference type="KEGG" id="tpe:Tpen_0481"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="OrthoDB" id="13967at183924"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="474" mass="54867" checksum="238CD12F1B8817CF" modified="2007-02-06" version="1">MVEEYMKGDGAVTGEGVEEFDEGFIREKLKELLRKAIFHRFNYSGLEATCTRVMWELINLKAEYQRYGEVYVELTNKAEVGVEKACRIAKRVFREALEHFEELKVRRTGKATWKVKIPGEKCRIYVYRKPAGHWAVEIRLYIRVTKFIVPDTLRLPPELLVDAQTGWLYGDASYIASRKDVRMGTSQAWQVTSFPGFWPGKEVEVYIRSVVIHETHVSVVWTVRVKGVRNAPKEWRLRKEEKQSVILSEIKAANEGEIDIFRAVRIATYYAADGKYPGPNTAKRLLEFGVGNEPYWIRVEGAVRIAKLLHEEVPQLLAFMCSAGCKKARYLARLALVEPKRNLSPRYLEVAGVRMNLQLVGTKNYRTLIARVFITNNNEELLRGFPERAREEGLIVKKMKIDKKYYGYYAGLRELMSYADKHLEAYDILIDFVKGELEEMPLDHPARQSVERLLERLKKARERALRKHAGGENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG5</accession>
    <name>A1RXG5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="6" type="ordered locus">Tpen_0487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0487"/>
    <dbReference type="EnsemblBacteria" id="ABL77895">
        <property type="protein sequence ID" value="ABL77895"/>
        <property type="gene ID" value="Tpen_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0487"/>
    <dbReference type="eggNOG" id="arCOG00785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_1_2"/>
    <dbReference type="OMA" id="TIMREEE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="84" mass="9744" checksum="6B680D0CAA0F55E2" modified="2007-02-06" version="1">MKRMAKQAEELRKMSREERQKRLQELRGELARLKAQAHRGSLENVASIRKIKREIARILTIENELRRKAPSAEQPPVQGSASQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG6</accession>
    <name>RS3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps3</name>
        <name type="ordered locus">Tpen_0488</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABL77896" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77896.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052885052.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXG6"/>
    <dbReference type="SMR" id="A1RXG6"/>
    <dbReference type="STRING" id="368408.Tpen_0488"/>
    <dbReference type="EnsemblBacteria" id="ABL77896">
        <property type="protein sequence ID" value="ABL77896"/>
        <property type="gene ID" value="Tpen_0488"/>
    </dbReference>
    <dbReference type="GeneID" id="4601786"/>
    <dbReference type="KEGG" id="tpe:Tpen_0488"/>
    <dbReference type="eggNOG" id="arCOG04097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_1_1_2"/>
    <dbReference type="OrthoDB" id="60366at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000293932" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="202" mass="22339" checksum="C1FCED72DFB08ED6" modified="2007-07-10" version="2">MSTTARKVISQGLQYMMLNEYLQRQLVRANYVHAQFFKTPIGTKVIVYAGVPGLVIGRKGANIKAIAEVLEREFGIENPQIDVVEVPNQDLNAKIMAYRVARALVRGVRFRRAALVALNRIMAAGARGAEIVISGKLTSQRHRTEKFTRGYVPKSGEPGEELVDEAIVHVLLKLGMYGVKVRIMKPAKMPDTILIKGVTQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH1</accession>
    <name>A1RXH1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytosine(72)-C(5))-methyltransferase</fullName>
            <shortName evidence="4">tRNA:m(5)C72 MTase</shortName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:61988"/>
            <dbReference type="Rhea" id="RHEA-COMP:15996"/>
            <dbReference type="Rhea" id="RHEA-COMP:15997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0494"/>
    <dbReference type="EnsemblBacteria" id="ABL77901">
        <property type="protein sequence ID" value="ABL77901"/>
        <property type="gene ID" value="Tpen_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0494"/>
    <dbReference type="eggNOG" id="arCOG00986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_1_0_2"/>
    <dbReference type="OMA" id="YQGAMLY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02237">
        <property type="entry name" value="NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043699">
        <property type="entry name" value="NSUN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="106"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="209"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="389" mass="43676" checksum="6BA367FBC65541F1" modified="2007-02-06" version="1">MSSVGAVASRYGYRVDFVEYLARFFSLGYIEDLFRSLETPGSRYFFRVNTLKVRPEDLLEELREEGLKVYRHDRLPEAFYVPVEGPFEVRLLPGKVYVDKKTAESVYVGANVFAPGVTKVENAREGDLVSVIAPGGRVVAEGVLSMDPSRVFSERKGLAVRVVRSVYRAVSLRETRYFDEGLIYHQSLPSMVAVRLLDPQPGWTVLDMCAAPGGKTTHAAQLMGDHGEVIAVDRTKSKVDTIMEHARRLGLKSVKGLVYDSRYISEYLDKDSVDAVIIDPPCTALGVRPKLWYERGFDDVLKLSDYQRQFLREAAKVLRRGGRLLFTTCTISPYENEFNVIFAASYLGLKPLPLSFPPVKSGLLGTGSLQFVPHEHDTPGFFIALFEKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ1</accession>
    <name>RS15_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps15</name>
        <name type="ordered locus">Tpen_0515</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752186.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXJ1"/>
    <dbReference type="SMR" id="A1RXJ1"/>
    <dbReference type="STRING" id="368408.Tpen_0515"/>
    <dbReference type="EnsemblBacteria" id="ABL77921">
        <property type="protein sequence ID" value="ABL77921"/>
        <property type="gene ID" value="Tpen_0515"/>
    </dbReference>
    <dbReference type="GeneID" id="4601353"/>
    <dbReference type="KEGG" id="tpe:Tpen_0515"/>
    <dbReference type="eggNOG" id="arCOG04185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_2"/>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="OrthoDB" id="98179at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000354232" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="148" mass="17388" checksum="A20000139FE42EDE" modified="2007-02-06" version="1">MRKSKEKGRSGSTRPPQLKKPEWVKMRPEEVEELVVSLYRKGYPPSMIGVILRDQYGIPMVKAVTGKSVLQILRERGLAPEIPEDLMNLMKRAIRVRKHLEEHPKDYHSKRGLQLIESKIHRLVKYYKREGILPPDWKYEPSKIALYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK6</accession>
    <name>A1RXK6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin/actin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752201.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0530"/>
    <dbReference type="EnsemblBacteria" id="ABL77936">
        <property type="protein sequence ID" value="ABL77936"/>
        <property type="gene ID" value="Tpen_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="4601348"/>
    <dbReference type="KEGG" id="tpe:Tpen_0530"/>
    <dbReference type="eggNOG" id="arCOG05583">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627936_0_0_2"/>
    <dbReference type="OMA" id="WTRFLIG"/>
    <dbReference type="OrthoDB" id="31455at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="428" mass="48271" checksum="587338CF47B88522" modified="2007-02-06" version="1">MVAGLAISEYKRKYAYGEDYGTSQFKFGPVAEKPLVIDNRGLLLAGESRLLLDIFGVRKEVVVGPELPKYLGSIDDVGRYLVYPMRDGLVEKDDERAWRVLYEITRYGFETTKPKAKDFDGFFVTAALSAIAPDYMYQRIFEIHARLDAEEKVVKAVTIIPQPLAVAIAEKTVTCVVVESGHGNTQITPISMYPIRNAIVALNRGGAEADAIAAEILRDLGYEDRAREEKFVRQFKEAVGLIPRDLNQAIEKARREPERFRTVFSIPGTVIQVDMGNMGWARFLIGEIIFNPEHEIFESYYKRGMPRPKDTVVGGERVRGTMPLVQAITHSVSRTSTELQPALYKDIILSGGNFAWKVPQGLEDVAVDSATKVALELKRLGIESNVRLVSDPLYSVWKGTIVYSIAVPEDVEWDWKRREGWYKRGVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP3</accession>
    <name>A1RXP3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuS</name>
        <name evidence="10" type="ordered locus">Tpen_0568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0568"/>
    <dbReference type="EnsemblBacteria" id="ABL77973">
        <property type="protein sequence ID" value="ABL77973"/>
        <property type="gene ID" value="Tpen_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0568"/>
    <dbReference type="eggNOG" id="arCOG00809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_2"/>
    <dbReference type="OMA" id="AWNMAFQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="30"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="732"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="658"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL77973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="977" mass="112855" checksum="A16524F449470432" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR9</accession>
    <name>A1RXR9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752264.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0594"/>
    <dbReference type="EnsemblBacteria" id="ABL77999">
        <property type="protein sequence ID" value="ABL77999"/>
        <property type="gene ID" value="Tpen_0594"/>
    </dbReference>
    <dbReference type="GeneID" id="4601234"/>
    <dbReference type="KEGG" id="tpe:Tpen_0594"/>
    <dbReference type="eggNOG" id="arCOG00333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_6_0_2"/>
    <dbReference type="OMA" id="MFAGDWE"/>
    <dbReference type="OrthoDB" id="21885at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="446" mass="49637" checksum="E52500D9C5E46468" modified="2007-02-06" version="1">MSWEGYNYEDVRRAAEETTSHLTPVSLHFLENCVSCALCEVNCPYTPVGEEYGPVSKAEPLRNIYRGKVNILPRLFPWLFGAKLPKTKEELDKWVDLAYHCTNCGLCYITCPFGIHSGEMIKTLRGFLAKTGRIPSLLKLMVDAETSGMFAENPGFRGLWEDVIRKTLEVANVEFDRKGAKYLYMPSLAEAMITPGAIPATARILSKLGLNWTMPRNPLSIRAPIGSLAGDDESVRVVAKRIYDYIKSIGAEYVVFSDGGYPYTFFRFDLPRIVGEEPSFKVVHVVELLVDALREGKVKFKQTQERITWHSPCKMGRFGGLIEEPVEVLSSISQNFVKLKSHGLFSKCCGGGGSIACIVPPTQEFMEKVMGIPLKVSENEKAFLDKLYRDMLIAGREKVQEIKESGASTVVTACIGCIHTLGFTTRAYDVKVTLKTLAEVVAEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS0</accession>
    <name>A1RXS0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">Tpen_0595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752265.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0595"/>
    <dbReference type="EnsemblBacteria" id="ABL78000">
        <property type="protein sequence ID" value="ABL78000"/>
        <property type="gene ID" value="Tpen_0595"/>
    </dbReference>
    <dbReference type="GeneID" id="4601235"/>
    <dbReference type="KEGG" id="tpe:Tpen_0595"/>
    <dbReference type="eggNOG" id="arCOG04426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_2_0_2"/>
    <dbReference type="OMA" id="EDIHFIP"/>
    <dbReference type="OrthoDB" id="109617at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="16440" checksum="D4E5D71C0743B047" modified="2007-02-06" version="1">MHEWSLMQAVVEALLEFAGRNGFSRISRVVVEVNEVSQLEEDILREAYSVLTENTIAEGSTLVIEKVPARFTCNSCGYTFSLEEARRALERLGEYAIPDEEGTLDMPTHYIPAVIHGFLRCPRCGSRDIWADMTSSLRVKAVEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT5</accession>
    <name>A1RXT5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0611"/>
    <dbReference type="EnsemblBacteria" id="ABL78015">
        <property type="protein sequence ID" value="ABL78015"/>
        <property type="gene ID" value="Tpen_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0611"/>
    <dbReference type="eggNOG" id="arCOG01431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_2"/>
    <dbReference type="OMA" id="FKFRGGW"/>
    <dbReference type="OrthoDB" id="82750at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="408" mass="44064" checksum="2AF9F5C69080611C" modified="2007-02-06" version="1">MSVDEKLFEELSIRIKEARDVLRNVIHRTPLQASKTLSDLTNSEVYLKLENLQKTGAFKVRGAYYKLQKLARSGVKSVVAASSGNHAQGVAYSASLLGIKSTIVMPRYTPFYKVNATKSYGAEVVLHGETYDDAYLKALEIAEKTGSPFVHPFNDPDIIAGQGTIGVEIFEDLSNVDLVLVPVGGGGLISGIAVALKKLKPDVKVVGVQPRGAPAMYLSFHEKRIVETPQVNSIADGVIVKRPGDLTLRIMEEFVDDVVLVDDREIARAMFLLLERVKTVAEPAGALSVAALTSGAVSAEGKRVVAVVSGGNVDPALLVRILGQVLYAEGRQVRIQGVLPDKPGQLKKVIDVVSELGLNIVEIQHERLNPLLSPGMAQVTLGLEVPSREYADMLILKLKAQGLDFKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT7</accession>
    <name>A1RXT7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Elongation factor 2</fullName>
            <shortName evidence="7">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fusA</name>
        <name evidence="9" type="ordered locus">Tpen_0613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752282.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0613"/>
    <dbReference type="EnsemblBacteria" id="ABL78017">
        <property type="protein sequence ID" value="ABL78017"/>
        <property type="gene ID" value="Tpen_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="4601319"/>
    <dbReference type="KEGG" id="tpe:Tpen_0613"/>
    <dbReference type="eggNOG" id="arCOG01559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="OrthoDB" id="1642at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="7">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="734" mass="82756" checksum="B57639A9C6D85058" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT8</accession>
    <name>A1RXT8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0614"/>
    <dbReference type="EnsemblBacteria" id="ABL78018">
        <property type="protein sequence ID" value="ABL78018"/>
        <property type="gene ID" value="Tpen_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0614"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504931_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="473"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="532" mass="58595" checksum="5C47FD7EE3AFC9A1" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU4</accession>
    <name>A1RXU4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752289.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0620"/>
    <dbReference type="EnsemblBacteria" id="ABL78024">
        <property type="protein sequence ID" value="ABL78024"/>
        <property type="gene ID" value="Tpen_0620"/>
    </dbReference>
    <dbReference type="GeneID" id="4601326"/>
    <dbReference type="KEGG" id="tpe:Tpen_0620"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_0_0_2"/>
    <dbReference type="OMA" id="VVYPWNF"/>
    <dbReference type="OrthoDB" id="110748at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="47"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="256" mass="29351" checksum="9F9270D3E566C7EC" modified="2007-02-06" version="1">MVLSRANHLPAHVTKNCATKAFSSCTVKLYVTTKTKVNTKLVLWEEVVEWCRSLAEKVKSSGFTPDIVVAIARGGYVPARLLCDFLDVHDLASIQVLHWGRAAEITSVAHVKYPYQLNLSGKRVLLVDDIVDTGDSVIVARDYILSNWKPAELKIAAMQWISPVAKIKPDFYVEEVKEWVWYQYPWTRAEDTTNFLEKIVSEGRKTGKTEWTFEELVSEFREIYGIDVGEKYYRLALNRLVEMGLLEKKGERYIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW0</accession>
    <name>A1RXW0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0637"/>
    <dbReference type="EnsemblBacteria" id="ABL78040">
        <property type="protein sequence ID" value="ABL78040"/>
        <property type="gene ID" value="Tpen_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0637"/>
    <dbReference type="HOGENOM" id="CLU_1269995_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="217" mass="23869" checksum="20A0811C779F5085" modified="2007-02-06" version="1">MCVMEHLGSVGAKLQGYKHIYHAKSVPVTVEPDSSCSEKRSLLAKLVSIYGWDFSLIPLGSESVKIPCELIDEKVAGLAIPVYVYSRLTGASEEVLLGVDPGASHSGVVFAVKYTPVVWTTVPQETLIDVISKLANYFQRIIVFAGSYGARYFPDLGNIPLGKLVVKIIDEERVRRLTSGVLGDEAIKRLDDHMRDAHRIFALGVAETLRERLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY03</accession>
    <name>A1RY03_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0681"/>
    <dbReference type="EnsemblBacteria" id="ABL78083">
        <property type="protein sequence ID" value="ABL78083"/>
        <property type="gene ID" value="Tpen_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0681"/>
    <dbReference type="eggNOG" id="arCOG04318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_2"/>
    <dbReference type="OMA" id="EKTHGDI"/>
    <dbReference type="OrthoDB" id="100043at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="208" mass="23710" checksum="6EDC8F2BCCF2054E" modified="2007-02-06" version="1">MKAELALIAKELDELDAQREKMLVVTREITRRAREAIFALHHGDLGKAGTELERARELIKELYELKQTHPQLYYSGGVLNAQTEYVEASLLASLLAGEGLPGFEELLVEPQAYLAGLGDLVGELRRYVLNILREGMVDKAWSILEFMEEIYVELGKFSYPEALVPGLRHKVDVARVILENTRNDVLFFERSRDLAQRIERLLEAMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY21</accession>
    <name>A1RY21_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0699"/>
    <dbReference type="EnsemblBacteria" id="ABL78101">
        <property type="protein sequence ID" value="ABL78101"/>
        <property type="gene ID" value="Tpen_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0699"/>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048986_0_1_2"/>
    <dbReference type="OMA" id="ESMYYTI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="349" mass="38108" checksum="6058692460931242" modified="2007-02-06" version="1">MLCVDRDNDVGTVLNVKTPLVGEEAVLNAAVEYSLARPDDSDSNAMFAAVQTYRELRKTYGDGVEVALVAGLEREGVEGDMKILQELDQVLSQGRFDGVVLVSDGPTDEAVAPLIQSKLPIVSIRRVIVQQERGVEETFVLLVNYVKKAFTEENYKRYSLGLTGLFLVIYSLLSYFLPQFVWPILITALGGFMFFKGYDLGEYFSSIYKTKPITFASILLSIILSLLALIQGIYAVLKTPYIDFFGAIGRLLLAPVGAQLLAVDLLVLGAVLPFLGSLIDAAIAGKETRYSDALVIAVILMARQLAVETARFLSGGGDIRGVLTWSFVVLSSVVVMVVAFTLERGARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY46</accession>
    <name>A1RY46_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752391.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0724"/>
    <dbReference type="EnsemblBacteria" id="ABL78126">
        <property type="protein sequence ID" value="ABL78126"/>
        <property type="gene ID" value="Tpen_0724"/>
    </dbReference>
    <dbReference type="GeneID" id="4600844"/>
    <dbReference type="KEGG" id="tpe:Tpen_0724"/>
    <dbReference type="HOGENOM" id="CLU_1536741_0_0_2"/>
    <dbReference type="OrthoDB" id="128259at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="174" mass="19001" checksum="27606ADDE43D0987" modified="2007-02-06" version="1">MKTLRLLAVKIVWEWVMRNVKRLREDGEAGWREAGKVLERVLRGDSRTVALLLVLQSSTTAFTSAEEVVSNIFRPFRDAVAVFLAIAFGIGIIGFALIIVDALLSWFTGGSFGRSLAVGKFLKAAETLAIIPIIFLSVQIMKGIGIQEVSQVADILNSLLQRGWQIVLSALSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY55</accession>
    <name>A1RY55_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752400.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0733"/>
    <dbReference type="EnsemblBacteria" id="ABL78135">
        <property type="protein sequence ID" value="ABL78135"/>
        <property type="gene ID" value="Tpen_0733"/>
    </dbReference>
    <dbReference type="GeneID" id="4600853"/>
    <dbReference type="KEGG" id="tpe:Tpen_0733"/>
    <dbReference type="eggNOG" id="arCOG15003">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2178024_0_0_2"/>
    <dbReference type="OrthoDB" id="131544at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="11719" checksum="21FF7C4BBD50E1EC" modified="2007-02-06" version="1">MFIRREDAVREASSYLVKAILVNSIAVFIPPLYIFFSGHIGPDTIVALAFLAVSIASLLLIYYVRRAVEDYSISSALSVAPLAVALGYVGGLVVTGFLVQKAQKALKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY78</accession>
    <name>A1RY78_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MJ1316 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0756"/>
    <dbReference type="EnsemblBacteria" id="ABL78158">
        <property type="protein sequence ID" value="ABL78158"/>
        <property type="gene ID" value="Tpen_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0756"/>
    <dbReference type="eggNOG" id="arCOG01302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172276_3_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="83" mass="9520" checksum="23B894778F3DF813" modified="2007-02-06" version="1">MRNYLNRLLWDKTLDKSSVVVKFISRSAVSDEGSFLGTQVLRVTRDGVVISVEGFEKFIPFTRITEIEENGRVVFSKKLGVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY91</accession>
    <name>A1RY91_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752436.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0769"/>
    <dbReference type="EnsemblBacteria" id="ABL78171">
        <property type="protein sequence ID" value="ABL78171"/>
        <property type="gene ID" value="Tpen_0769"/>
    </dbReference>
    <dbReference type="GeneID" id="4601091"/>
    <dbReference type="KEGG" id="tpe:Tpen_0769"/>
    <dbReference type="eggNOG" id="arCOG03859">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992555_0_0_2"/>
    <dbReference type="OMA" id="HAYHILE"/>
    <dbReference type="OrthoDB" id="110919at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="280" mass="31413" checksum="8A07974009801657" modified="2007-02-06" version="1">MRGDVSTDALEYEKVYEILGNPLKRSILRILGERGEASFTELKSSLKTSTGNLYYNLDGMEGFVTKNEKRRYTLTEKGIRLYRFMLEEDARLRNIVAEKRGFAALVEKYFLPVIVPESLAAAFYHERSLSLVILGASLLLGALPSALGAQVVFMMDQLALPYRLIPLGFFFFVLGALVLLLVVELVQRVLGGHGGYSVDYLGAFFASLLPVYAFNVLQAALPWDPFTLSLLYRLVQVPTLGLLTATLAVYKRLPRDRAFIASFVAYYSSYMASMMLQRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA4</accession>
    <name>A1RYA4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Indolepyruvate ferredoxin oxidoreductase, subunit iorB</fullName>
            <ecNumber evidence="4">1.2.7.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752449.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0782"/>
    <dbReference type="EnsemblBacteria" id="ABL78184">
        <property type="protein sequence ID" value="ABL78184"/>
        <property type="gene ID" value="Tpen_0782"/>
    </dbReference>
    <dbReference type="GeneID" id="4601843"/>
    <dbReference type="KEGG" id="tpe:Tpen_0782"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_2"/>
    <dbReference type="OMA" id="HGMSQRF"/>
    <dbReference type="OrthoDB" id="120779at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="199" mass="20817" checksum="7A1A154047921643" modified="2007-02-06" version="1">MAGKSIVIAGVGGQGLITIGTVVAQALIRKGYSVRVGEVHGLSQRGGSVVVFLKYGQGPLSPIVDQGEADVLLGLELIETLRRVPLLSKEGVVLANNFFLPPPAAKSPSRSAVLNALKGLGARVVLLEADELALKAGSPITVNMVMLGALIGTGRIDLTLEDAADVLRSRFKGKVLEMNLEALKLGYTAAQEQLEGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB3</accession>
    <name>A1RYB3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0791"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78193">
        <property type="protein sequence ID" value="ABL78193"/>
        <property type="gene ID" value="Tpen_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0791"/>
    <dbReference type="eggNOG" id="arCOG03280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026700_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015179">
        <property type="entry name" value="A-amylase/a-glucTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015178">
        <property type="entry name" value="A-amylase/a-glucTrfase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09094">
        <property type="entry name" value="DUF1925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09095">
        <property type="entry name" value="DUF1926"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1925" evidence="2">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1926" evidence="3">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1926" evidence="3">
        <location>
            <begin position="384"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="598" mass="69270" checksum="12AD2AD549957710" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB5</accession>
    <name>A1RYB5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752460.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0793"/>
    <dbReference type="EnsemblBacteria" id="ABL78195">
        <property type="protein sequence ID" value="ABL78195"/>
        <property type="gene ID" value="Tpen_0793"/>
    </dbReference>
    <dbReference type="GeneID" id="4601254"/>
    <dbReference type="KEGG" id="tpe:Tpen_0793"/>
    <dbReference type="eggNOG" id="arCOG00921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109226_0_0_2"/>
    <dbReference type="OMA" id="TRVTWVD"/>
    <dbReference type="OrthoDB" id="105306at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022285">
        <property type="entry name" value="CHP03879_regulat_dom_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03879">
        <property type="entry name" value="near_KaiC_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="15877" checksum="62F641144EE2FE9E" modified="2007-02-06" version="1">MEVPLKPVGKEDTRKLELALILGTLMRSDVLEKIRIAEDKITWLDSLVIAAGALARERAGYPVTKIAEELGRTEATIRNHLQGKTEAGKIVRETYEAFVKSGGKVELVLPGGEELERLRRENEELKKKLESVKSALQSLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB7</accession>
    <name>A1RYB7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein, transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752462.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0795"/>
    <dbReference type="EnsemblBacteria" id="ABL78197">
        <property type="protein sequence ID" value="ABL78197"/>
        <property type="gene ID" value="Tpen_0795"/>
    </dbReference>
    <dbReference type="GeneID" id="4601256"/>
    <dbReference type="KEGG" id="tpe:Tpen_0795"/>
    <dbReference type="eggNOG" id="arCOG02087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315154_0_0_2"/>
    <dbReference type="OrthoDB" id="67596at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="927" mass="100913" checksum="4F0849E5EAE8E329" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD1</accession>
    <name>A1RYD1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase</fullName>
            <ecNumber evidence="9">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752476.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0810"/>
    <dbReference type="EnsemblBacteria" id="ABL78211">
        <property type="protein sequence ID" value="ABL78211"/>
        <property type="gene ID" value="Tpen_0810"/>
    </dbReference>
    <dbReference type="GeneID" id="4602141"/>
    <dbReference type="KEGG" id="tpe:Tpen_0810"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="KCSQVMY"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="161"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="264"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="364"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="447" mass="48571" checksum="B507D8536ED6537C" modified="2007-02-06" version="1">MSFPAHIFRAYDIRGVYGVDLNPAIAVAIGNALSRLFPGEYCVCSDTRSSSPALKAALSAGLAGSGSNVVDGGTGPIGMAIYATKHLEYHVAYVTASHLPPEWNGIKLFKPRGIPICEEDLKKLGEVAAGNLEWAKPGSEGAYTHRDVLYEYYKFLLKVGKTSSRRTRVVVDCGNGAASLIVPRLLRSLGYDVVGINCDVDPLFSVRGSEPTLESTAYLKDVVLRFRADLGVSFDGDGDRAIFFDEKGNPLAPEQAAVVILKGSQPGDVIANVECSSMVEKYVASRGGRVVRVPVGRIHMIFESMKSSFVLGVESSGHYVPYGGLNLDDGILAVLQFLEAFEKLGGPVSALVEPMPLMRKVKLEVNEEVKFKAVEYLKAYYAGKYDRVDTTDGVRVDLDYGWFLVRASNTEPVIRVTIEASTKEDLDKLEKLVREDIERALSAARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE6</accession>
    <name>A1RYE6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752491.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0825"/>
    <dbReference type="EnsemblBacteria" id="ABL78226">
        <property type="protein sequence ID" value="ABL78226"/>
        <property type="gene ID" value="Tpen_0825"/>
    </dbReference>
    <dbReference type="GeneID" id="4601828"/>
    <dbReference type="KEGG" id="tpe:Tpen_0825"/>
    <dbReference type="eggNOG" id="arCOG04144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085935_0_0_2"/>
    <dbReference type="OMA" id="VKMFGYA"/>
    <dbReference type="OrthoDB" id="108705at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015254">
        <property type="entry name" value="AGOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09171">
        <property type="entry name" value="AGOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="283" mass="31871" checksum="3CB85F2F79CB6B52" modified="2007-02-06" version="1">MIFFDEKRASELGEIFRGSIRELSLLFVERDPQFLAVRKILEKAGFPEGGFYVAGVALVSYMLSKRGEDHWLEAAELFDGTPGALYRFVEEAESLRRFREHRVKRIKRYVASREKVLSLLSEVPVNLERFASTVARIVGANPEDKTVVFASKMLLYACIAANKEYTGGERLPIPVDYRVSLVTLTSGIAKGWSCLDDLRAHASNLRAKHKEEVKAAWSLVGRQAEIPPILLDAPVWLVGGCIDRGDFEVKRIDECLEENFAGAPLHALRELYAELRRCQAESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF5</accession>
    <name>A1RYF5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78235">
        <property type="protein sequence ID" value="ABL78235"/>
        <property type="gene ID" value="Tpen_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0834"/>
    <dbReference type="eggNOG" id="arCOG10103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217438_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="45" mass="5330" checksum="8DA5D817912585C4" modified="2007-02-06" version="1">MSEKEKPKYVDLSDEEVEELIRKRLREIKDVLSDIKQILEEAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL4</accession>
    <name>A1RYL4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752559.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0893"/>
    <dbReference type="EnsemblBacteria" id="ABL78294">
        <property type="protein sequence ID" value="ABL78294"/>
        <property type="gene ID" value="Tpen_0893"/>
    </dbReference>
    <dbReference type="GeneID" id="4600470"/>
    <dbReference type="KEGG" id="tpe:Tpen_0893"/>
    <dbReference type="eggNOG" id="arCOG04201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="OrthoDB" id="24323at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="6">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="72"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="522"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="638" mass="71746" checksum="7ED2F1993095A6FB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM6</accession>
    <name>A1RYM6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752571.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0905"/>
    <dbReference type="EnsemblBacteria" id="ABL78306">
        <property type="protein sequence ID" value="ABL78306"/>
        <property type="gene ID" value="Tpen_0905"/>
    </dbReference>
    <dbReference type="GeneID" id="4602228"/>
    <dbReference type="KEGG" id="tpe:Tpen_0905"/>
    <dbReference type="eggNOG" id="arCOG01798">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_2"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="OrthoDB" id="70745at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="218" mass="23878" checksum="A0793D13938D4944" modified="2007-02-06" version="1">MGLLDFVYEYTPFIAEGVVVTLQISVISFLLGLALGIALLGLSLTSLRPLARMYIEPVRGTPLLVQLLLIYFGLPSIGIKLDAFTSSFLALGLNSAAYQAEIFRSALKSIPDVQILSAESLGFSGSQVYRYVILPQALRISIPSLVNEFVTVVKESSLASVIGIVELTRRGEYVAAYTYRALESYLVVAAIYFAVCYLISYLSRRIEEKIRIPGYTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ5</accession>
    <name>A1RYQ5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHHA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752600.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0934"/>
    <dbReference type="EnsemblBacteria" id="ABL78335">
        <property type="protein sequence ID" value="ABL78335"/>
        <property type="gene ID" value="Tpen_0934"/>
    </dbReference>
    <dbReference type="GeneID" id="4600757"/>
    <dbReference type="KEGG" id="tpe:Tpen_0934"/>
    <dbReference type="eggNOG" id="arCOG00431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846278_0_0_2"/>
    <dbReference type="OMA" id="RWDFVAD"/>
    <dbReference type="OrthoDB" id="86898at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="173"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="326" mass="35902" checksum="DCACE35E7B1A79A2" modified="2007-02-06" version="1">MSLYVSLYRAYQIARALIEKRPLALSDAGDVDGVVSATLFKISRPSAEIVLAHPTDVARSPILRRVYWDFVADLPCPGKAKLRADHHVTNTPCADEEYYDPSAPASALLAYKALSLEGNATATRLVELAVETDTANIKSREALLLDSAVKGAGYRGKLYLVRLLAEKGLDALNDEKVKEWIARHEEVRLRTESLAEKIPVEEVTVVAFRKRLKLSYRYLTILLERRGAKFTLVLVPRGLFKYRVYAGAQPESSYDASTVASRLGGGGHKFAAGALFRATSLRQALEKALEAAKTGAGVDPQKVVVVSDYNCIKEVYMEGKNKKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR1</accession>
    <name>A1RYR1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752606.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0941"/>
    <dbReference type="EnsemblBacteria" id="ABL78341">
        <property type="protein sequence ID" value="ABL78341"/>
        <property type="gene ID" value="Tpen_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="4601070"/>
    <dbReference type="KEGG" id="tpe:Tpen_0941"/>
    <dbReference type="eggNOG" id="arCOG00506">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066633_0_0_2"/>
    <dbReference type="OMA" id="HASGNFH"/>
    <dbReference type="OrthoDB" id="56201at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="27484" checksum="65C4667CC3B36656" modified="2007-02-06" version="1">MILLYTSENHRVAVFRELTPKGQVQTNQFIIVDGDEALLADTSGRAVFAKLLSQVSVLAPPTKVKYLFYTHQDPDVIGAAASWYTALPNAKIVLPELWVRFLPHVFPPDVNIENRVVPVGDSGAELQLGNCTLKLIPAHFLHSPGNFSLYDPCSKILYSGDVLASLLPPDKDYDFAPSFEEHVKYMEPFHKRYMASGKALKAWVSRVKALDVETIVPQHGAILKSKEVVQKALAWLENLEAGVDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW1</accession>
    <name>A1RYW1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752656.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0991"/>
    <dbReference type="EnsemblBacteria" id="ABL78391">
        <property type="protein sequence ID" value="ABL78391"/>
        <property type="gene ID" value="Tpen_0991"/>
    </dbReference>
    <dbReference type="GeneID" id="4601967"/>
    <dbReference type="KEGG" id="tpe:Tpen_0991"/>
    <dbReference type="eggNOG" id="arCOG01205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159724_1_0_2"/>
    <dbReference type="OMA" id="SKWREYA"/>
    <dbReference type="OrthoDB" id="122104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12434" checksum="63BD492C6A067D47" modified="2007-02-06" version="1">MSSWVKYHFAHLRRWREYAEAVAKAAKDLRPDAEVYVVGSVAEGRATVLSDIDILVVLEKAGNEDRKYLPADIVDRAVEKYSLPVDAPVEIHVASREELARWAGKAMIKVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX4</accession>
    <name>SURE_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">surE</name>
        <name type="ordered locus">Tpen_1004</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752669.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYX4"/>
    <dbReference type="SMR" id="A1RYX4"/>
    <dbReference type="STRING" id="368408.Tpen_1004"/>
    <dbReference type="EnsemblBacteria" id="ABL78404">
        <property type="protein sequence ID" value="ABL78404"/>
        <property type="gene ID" value="Tpen_1004"/>
    </dbReference>
    <dbReference type="GeneID" id="4601560"/>
    <dbReference type="KEGG" id="tpe:Tpen_1004"/>
    <dbReference type="eggNOG" id="arCOG02303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_3_2"/>
    <dbReference type="OMA" id="MHVEERI"/>
    <dbReference type="OrthoDB" id="110625at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000007797" description="5'-nucleotidase SurE">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <sequence length="260" mass="27553" checksum="EF84DD04219D964E" modified="2007-02-06" version="1">MKILVTNDDGPFSPGLAILREAVRGLGEATVVVPETPKSATGLGLTLHKPLRVNRLSLDGEPVYLVSGTPSDVIYIAMNVISGKPDLVVSGVNIGDNLSVQVILTSGTLGAVLQASIEGVPGIAFSAAVDTPEELEEGEYRNFVLRSTKAIVRAVVGEGFPKGVDALNVNFPSVIASDVVVVRPALKRFSTAVVRRKDPQGRPYYWLYGHPVEAEEGSDVHAVLEEGKIAITPLSLSGMLSYSPEALSGIVKKVKEELSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ10</accession>
    <name>COXX_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ctaB</name>
        <name type="ordered locus">Tpen_1040</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752705.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZ10"/>
    <dbReference type="SMR" id="A1RZ10"/>
    <dbReference type="STRING" id="368408.Tpen_1040"/>
    <dbReference type="EnsemblBacteria" id="ABL78440">
        <property type="protein sequence ID" value="ABL78440"/>
        <property type="gene ID" value="Tpen_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="4600945"/>
    <dbReference type="KEGG" id="tpe:Tpen_1040"/>
    <dbReference type="eggNOG" id="arCOG00479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_0_1_2"/>
    <dbReference type="OMA" id="QFFWQFP"/>
    <dbReference type="OrthoDB" id="97092at2157"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000346096" description="Protoheme IX farnesyltransferase">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <sequence length="282" mass="29523" checksum="F45AFBEEDE9736CD" modified="2007-02-06" version="1">MAPSAKDLLELFKVKQTALLLVTGVCAYLEGAGKPDPATLVLASLSMFLSIAGTTGFNMVLDADIDSAMFRTRNRPLPARRMSAKDAVLASSAALAAGLAAGVAVNPYVFVAGLLGFLIDIAVYTVLLKRKSPWSVVFGGFAGGMPALGGWAAATGGFGYQGVLLMLLVAVWSSLHIWTLSTYYSEDYRRAGVPMLPAVYGERAGVVASLAAAVAVFLVAFLAFRAGLISAVGFAVAAVPLVLAVAVLLKGLVSGEYREKAYRAFKLVNIFMGLFFVLLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ24</accession>
    <name>A1RZ24_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor synthesis domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1054"/>
    <dbReference type="EnsemblBacteria" id="ABL78454">
        <property type="protein sequence ID" value="ABL78454"/>
        <property type="gene ID" value="Tpen_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1054"/>
    <dbReference type="eggNOG" id="arCOG00217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_3_0_2"/>
    <dbReference type="OMA" id="IEAKTHS"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="189"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="651" mass="70597" checksum="5BFC8253B41C7B6B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ50</accession>
    <name>A1RZ50_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Ubiquinone)</fullName>
            <ecNumber evidence="2">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1081"/>
    <dbReference type="EnsemblBacteria" id="ABL78480">
        <property type="protein sequence ID" value="ABL78480"/>
        <property type="gene ID" value="Tpen_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1081"/>
    <dbReference type="eggNOG" id="arCOG01548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="1">
        <location>
            <begin position="138"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="404" mass="45686" checksum="7DF581E3F31A6BF1" modified="2007-02-06" version="1">MLSTSSGVVYSRLLLREGDESVYELFIGPQHPSSGHMRFIVRLQGDVIVSVDPDIGYVHRTMEKLAEGREAIKAIPLLERLTIIDSHNATVGLVTAMERLLDVEPPPRALYLRTLLSEINRIASHLYGMGIAGIMLNHSTMFMWAFGDREVWLQLAEELTGARLTHTYSVPGGVRRDLPQGFGEKFEKAARYMERRLQDYMRIFLENPQVVARYEGVGVLKKSEASRLGVVGPNLRASGVKYDARLADDYGAYKDLEFEVPTREEGDCMARMLVRVEEIKQSISIIRQVLRKMPDGPILSEKYLKLLPPKTRERVLQEGRVKFPALFASLKLPAGEAVARAEMGHGEIFYHITGDGSAKPYRLRVVTPSFRNVILFRYLAPGHRFMDFPAIYGSLDYFPPEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ89</accession>
    <name>A1RZ89_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752784.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1121"/>
    <dbReference type="EnsemblBacteria" id="ABL78519">
        <property type="protein sequence ID" value="ABL78519"/>
        <property type="gene ID" value="Tpen_1121"/>
    </dbReference>
    <dbReference type="GeneID" id="4600863"/>
    <dbReference type="KEGG" id="tpe:Tpen_1121"/>
    <dbReference type="eggNOG" id="arCOG01491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_2"/>
    <dbReference type="OMA" id="DQMPKHV"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="812" mass="90128" checksum="0EBE59274B1DBA2C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ95</accession>
    <name>A1RZ95_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752790.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1127"/>
    <dbReference type="EnsemblBacteria" id="ABL78525">
        <property type="protein sequence ID" value="ABL78525"/>
        <property type="gene ID" value="Tpen_1127"/>
    </dbReference>
    <dbReference type="GeneID" id="4602022"/>
    <dbReference type="KEGG" id="tpe:Tpen_1127"/>
    <dbReference type="eggNOG" id="arCOG00753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_0_1_2"/>
    <dbReference type="OMA" id="GVMTIMN"/>
    <dbReference type="OrthoDB" id="9099at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="4">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="384" mass="41633" checksum="231B09BE90187A97" modified="2007-02-06" version="1">MTKKVVVIGGGVTGAALAYDLALRGLRVTLLERGSIGSGTSGRTHGLLHSGCRYVADVEVARECYSENVVLRRIAPFLFEKNGGIFVAVDESDLEYKDFFLKKCEEAGIPVKEVSREEALKLEPNLNPDLKAAVLVPDGTFDPLKVILSFLASAKQRGADIRPYNEVVGFRVEGGEVKAVKVRDKVSLREYELEADFFVNATGAWAKKVARLAGLDVPVKPSPGVMVALDGRVGFRVFNRLNKPGDGDIIVHHRGTSVIGTTSWVVEDPDKVEAPREHVELLLRRGRELAPVTSKLRVKAVYVSSRPLVGSLPAGTGREVSRSFAIIDHSREGAGNMASVIGGKFTTARLMAEKTGDFVAERLGVSTPSRTAETPLAPYWAYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA2</accession>
    <name>A1RZA2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1134"/>
    <dbReference type="EnsemblBacteria" id="ABL78532">
        <property type="protein sequence ID" value="ABL78532"/>
        <property type="gene ID" value="Tpen_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1134"/>
    <dbReference type="eggNOG" id="arCOG01615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078428_0_0_2"/>
    <dbReference type="OMA" id="EAFHIVV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015661">
        <property type="term" value="F:L-lysine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005642">
        <property type="entry name" value="LysO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35804">
        <property type="entry name" value="PTHR35804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03956">
        <property type="entry name" value="Lys_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="288" mass="29997" checksum="440675BC7B0B4838" modified="2007-02-06" version="1">MVPLDSWSVVTVFVASVVVGRALRLSLPKAFFDVSVGVLVWAISAWAASSGLEALKYSLAQTLLFLAAIVCYVVVLGALASRGAAHARAGARPRPNVYLLALIAVGWASGLSAGWLRPYLSEALPVLVLAVIAATGLTMHSALSVASLRRGGVVALKAVAVTLASAVLAGLTVAALLGLSPHYALSVTLGLGWYSFAGSFVAQFLGPEQGFTAFLVNILREQLTFALVPVISRFRVSAISLGGATTMDNTLPVYAYVYGDDAVVPSIVHGFLLTFLVPFLEALVVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA5</accession>
    <name>A1RZA5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752800.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1137"/>
    <dbReference type="EnsemblBacteria" id="ABL78535">
        <property type="protein sequence ID" value="ABL78535"/>
        <property type="gene ID" value="Tpen_1137"/>
    </dbReference>
    <dbReference type="GeneID" id="4601392"/>
    <dbReference type="KEGG" id="tpe:Tpen_1137"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032933_0_0_2"/>
    <dbReference type="OMA" id="YYPRYMM"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="93"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="260" mass="27608" checksum="2692946F5559BB67" modified="2007-02-06" version="1">MKAGDVARIFKAGVLFEVSMLKSNKGYFAATLARPYFVYALLLLISKQLGAGYTPRDVVVQTLAVTGSIDVLWDVAGQGILLRVSGVLPYYTLSPGGVLLALVVSYLPRYILETLLKAVAFLPVLALEEGPADALLHLLAAYALLLLGLLPLLGISTLVAGATLLVHEESPVLEWVTPLVLLLSGAVYPVSVLPGWMRALSALIPVTYVVELSRALEGGGGVQAFYSGAFALLISLSILYNAAASRLFRKAEEALLRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB0</accession>
    <name>A1RZB0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1142"/>
    <dbReference type="EnsemblBacteria" id="ABL78540">
        <property type="protein sequence ID" value="ABL78540"/>
        <property type="gene ID" value="Tpen_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1142"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8440" checksum="7530F96A74B11D41" modified="2007-02-06" version="1">MSDPRVTVRTIGALSRLLASTLRRDGLYEARLVEALDAVEEFLASVRSAPARLEEDEELARELEEDVEELRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB2</accession>
    <name>A1RZB2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative circadian clock protein, KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752807.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78542">
        <property type="protein sequence ID" value="ABL78542"/>
        <property type="gene ID" value="Tpen_1144"/>
    </dbReference>
    <dbReference type="GeneID" id="4600950"/>
    <dbReference type="KEGG" id="tpe:Tpen_1144"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="OMA" id="EKMRQTN"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022443">
        <property type="entry name" value="KaiC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03881">
        <property type="entry name" value="KaiC_arch_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="265" mass="30086" checksum="DEBDDC14D21957BC" modified="2007-02-06" version="1">MEARRLSTGVAGLDKLLAGGVPEGFFVALVGMPGTGKTIACLHFVWAGLKAGESAIYVTTEESRESIVRQAAQFGMDFEGAQKSGRLIIIDALMREKEDEWMMRELAVEEMLSRVIEAKKRLGRSARRLVIDSMSAFWLRAPVKAREDSYTVKRILNKWGFTIYATSQYAITTGSAFGWGIEHVADGIIHFKRRVVDGVLTRYIIVEKMRQTPHDLRAWEIQIRDKEGLTLVRPLARRLEDESLPEKVARRIKERAEEDEFARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB4</accession>
    <name>A1RZB4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1146"/>
    <dbReference type="EnsemblBacteria" id="ABL78544">
        <property type="protein sequence ID" value="ABL78544"/>
        <property type="gene ID" value="Tpen_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1146"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106706_0_0_2"/>
    <dbReference type="OMA" id="HDYGFPK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="26604" checksum="A55BC5BF29211B59" modified="2007-02-06" version="1">MKALGNCVILISCGGLCRLWGRALKVRVVSLDLDGTVVSREYVDYFWLELVPRLYARRHGLNLEEAKRLVYSAYDEVGPGDMRWYQPSYWFKRFGIEEWLGDALREAGRLVRVYEDARRFLESLPGSLIAVLSTSASREFVELVMEREPFLRGVFRRVFSSSSDYSLPGKPPEFFRIILRELGARPEEVVHVGDDPVHDYENPRKAGLRAYLLSRSGGDGIRGLDELLAVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD6</accession>
    <name>A1RZD6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752831.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1168"/>
    <dbReference type="EnsemblBacteria" id="ABL78566">
        <property type="protein sequence ID" value="ABL78566"/>
        <property type="gene ID" value="Tpen_1168"/>
    </dbReference>
    <dbReference type="GeneID" id="4601182"/>
    <dbReference type="KEGG" id="tpe:Tpen_1168"/>
    <dbReference type="eggNOG" id="arCOG02165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431268_0_0_2"/>
    <dbReference type="OrthoDB" id="25207at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="317"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="634" mass="68845" checksum="56B2A09B32045F37" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG0</accession>
    <name>A1RZG0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752855.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1192"/>
    <dbReference type="EnsemblBacteria" id="ABL78590">
        <property type="protein sequence ID" value="ABL78590"/>
        <property type="gene ID" value="Tpen_1192"/>
    </dbReference>
    <dbReference type="GeneID" id="4600437"/>
    <dbReference type="KEGG" id="tpe:Tpen_1192"/>
    <dbReference type="eggNOG" id="arCOG03427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120467_0_0_2"/>
    <dbReference type="OMA" id="VNSDFAT"/>
    <dbReference type="OrthoDB" id="122467at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="139" mass="14885" checksum="1E7CD44CFFEB32D9" modified="2007-02-06" version="1">MNEWFLLALLDAFFAALATIFAKIGLQNVDSITATALRSVVMMLFAVGMMLAFRGTGFVSTITSREALYILLSGIAGGASWVLYFLALQKGETTPVSLVDKSSLAFVVLLSVLILHEELTVKKIIAVGLVLAAIYILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG3</accession>
    <name>A1RZG3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LmbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752858.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1195"/>
    <dbReference type="EnsemblBacteria" id="ABL78593">
        <property type="protein sequence ID" value="ABL78593"/>
        <property type="gene ID" value="Tpen_1195"/>
    </dbReference>
    <dbReference type="GeneID" id="4600387"/>
    <dbReference type="KEGG" id="tpe:Tpen_1195"/>
    <dbReference type="eggNOG" id="arCOG03460">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_2_2"/>
    <dbReference type="OMA" id="EIVLCNA"/>
    <dbReference type="OrthoDB" id="79462at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="270" mass="30179" checksum="7BCA7244C5073C0E" modified="2007-02-06" version="1">MNEGSLEDYARKLASELGPEEALRRVAAELFEELKNPFEDAERVLCVGPHPDDCEYGAGGTLAYLARSGKRVVYLILTDGSKGTTSPGVDPRELAEIRRKEQEEAARIIGVEKVIWLGYPDTELPYTPEARNSVIRVIREERPDVVFSPDPWLLYEAHPDHRVGGLLAAEAVMLSPLPLVHVGAPHAVKRLVFYYTARPNFFQPVDGYVDIKLNALRSHRSQFEENWGLFELYLKTLMAAYGARVGARYAEPLRVLPATLLHATALSEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM3</accession>
    <name>A1RZM3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752918.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1255"/>
    <dbReference type="EnsemblBacteria" id="ABL78653">
        <property type="protein sequence ID" value="ABL78653"/>
        <property type="gene ID" value="Tpen_1255"/>
    </dbReference>
    <dbReference type="GeneID" id="4600421"/>
    <dbReference type="KEGG" id="tpe:Tpen_1255"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OrthoDB" id="46692at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="276" mass="29781" checksum="32D97150B7DE2A13" modified="2007-02-06" version="1">MKAEYAAAVLLLLLGALWAIPLYALVAGSLKNLADAMGTPVLQPPSQPDFGNVVAALEKFSSTIALTGLIVLPAAFAATLLGSLSAFAIRLYGGKVADWLPVVIALTTYIPYQAIIVPLVSVIRQVEVATGIPLYDTSQGLFLVLLVYYTPMATLLMFIFSNAMPREPIEASLVDGAGLPTIYWRVALPLLGPGFVSTLIFLLINMWNNLFIPLSMTRGYEKFVTLKIFSYVGQAGTIYNEMFAAALIGSLPPLVVFLFMSKYFIRGMLTLTGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM8</accession>
    <name>A1RZM8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752923.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1260"/>
    <dbReference type="EnsemblBacteria" id="ABL78658">
        <property type="protein sequence ID" value="ABL78658"/>
        <property type="gene ID" value="Tpen_1260"/>
    </dbReference>
    <dbReference type="GeneID" id="4600426"/>
    <dbReference type="KEGG" id="tpe:Tpen_1260"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1017884_0_0_2"/>
    <dbReference type="OrthoDB" id="123305at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="274" mass="28598" checksum="D2398C6443E9430B" modified="2007-02-06" version="1">MKSGVTAFALLALLAATQLALAQPLEVLYVLPGGLVQGYVVFTVPGTGFAEFKLPGSVESLGVTGTGSSPPVFNLSGGVLSVLADPGSTVNASFVSRLPRDSVTTLSVPAENQSLKVYVSSEYVVLGVSPTPTTIAYTQGYVLLGFDVLAEDLQVVLVETGSAQAGQGAPAAQQGGAPQLQQLLPYAVLVAVAVAAVLLALRLKRRGEGGVVLEEDEAILDFLRRSGGRAYLKEIREALGIPSTTLLRRVRRLEKAGYLRLEKTPGGLLVILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP5</accession>
    <name>A1RZP5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1277"/>
    <dbReference type="EnsemblBacteria" id="ABL78675">
        <property type="protein sequence ID" value="ABL78675"/>
        <property type="gene ID" value="Tpen_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1277"/>
    <dbReference type="eggNOG" id="arCOG02106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_1_2"/>
    <dbReference type="OMA" id="YLAVGQC"/>
    <dbReference type="OrthoDB" id="13590at183924"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="3">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="145" mass="16679" checksum="B626C6E240C4F696" modified="2007-02-06" version="1">MRSLEEIKFYEIDLEKVVETLKKYFEKRSDVAVAVLFGSALRRRKVRDIDIAVHADWSLEELLEATAELEKELGTPVDIVPLPNAPPQVRLKALAEGLPITVKNHALYTELLKEAIGETRDMEAKLREERRAKDRRQRRGETAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS0</accession>
    <name>A1RZS0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752965.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1302"/>
    <dbReference type="EnsemblBacteria" id="ABL78700">
        <property type="protein sequence ID" value="ABL78700"/>
        <property type="gene ID" value="Tpen_1302"/>
    </dbReference>
    <dbReference type="GeneID" id="4601596"/>
    <dbReference type="KEGG" id="tpe:Tpen_1302"/>
    <dbReference type="eggNOG" id="arCOG06086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202940_0_0_2"/>
    <dbReference type="OMA" id="KYARRRV"/>
    <dbReference type="OrthoDB" id="119159at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8854" checksum="F8E1B932A1EFDB86" modified="2007-02-06" version="1">MKVVSVKVPDYVSEREVLLWVAEGLSRKYARRRVLKLLEEGVAGVDAEKALEEFEETRSETWRTLEEEYRRRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S028</accession>
    <name>A1S028_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753073.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1411"/>
    <dbReference type="EnsemblBacteria" id="ABL78808">
        <property type="protein sequence ID" value="ABL78808"/>
        <property type="gene ID" value="Tpen_1411"/>
    </dbReference>
    <dbReference type="GeneID" id="4600728"/>
    <dbReference type="KEGG" id="tpe:Tpen_1411"/>
    <dbReference type="eggNOG" id="arCOG05634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120797_0_0_2"/>
    <dbReference type="OMA" id="EARCICG"/>
    <dbReference type="OrthoDB" id="94431at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="209" mass="23277" checksum="9ECD8C134282E15E" modified="2007-02-06" version="1">MNQFIDALFDSLCGGSEECKQALREVYSLFEGVEEVVRRLPKPVLRSFEEPLAGNVANRDEVVREAEALGVGEELSDYVVKRVTALEFGWVKPRGLKCPVCGQAPSLVLLEEEPSVGFAKQRAKARCICGYEREFERFTCPSCGSAGRQNFEVYVSRRTHAKLFVCRNCGYAFLEIPRNGLSESELQGVHASIRLVLKAGDTTRTHAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S041</accession>
    <name>A1S041_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753086.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1424"/>
    <dbReference type="EnsemblBacteria" id="ABL78821">
        <property type="protein sequence ID" value="ABL78821"/>
        <property type="gene ID" value="Tpen_1424"/>
    </dbReference>
    <dbReference type="GeneID" id="4600720"/>
    <dbReference type="KEGG" id="tpe:Tpen_1424"/>
    <dbReference type="eggNOG" id="arCOG03303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_13_1_2"/>
    <dbReference type="OMA" id="WLMPEYA"/>
    <dbReference type="OrthoDB" id="90656at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="374" mass="41220" checksum="D66FECE5FFFDFA24" modified="2007-02-06" version="1">MKAWKVAVLLLIVVAIAGAALLYYPAVKPREEQKPSVVWVVDYAGRNVSVPARVSRVVAIGPGALRLVSYLGAVDLVVGVEDAEKTWSVVGRDYAMVYSEFFRKLPTIGPGGPRSPPNPELIRSVKPDLVIMSRVYVELYDPDRLSQEVGAPVVVVDYGIAGYLNASEFKRAITLLGKILGKEERARELCSYVDSLVSDLASRAKGVEKKSIYVGAVSYKGAQPFTGTQGKFPPLQLIGTGSIADETGKVGFINVDFEFILKRQPAYVFIDLNNLNNVLDDFNKDKSKYCALEAFRAGRVYAILPFNYYHTNVATAFADAYYMGKVLYPDRFADVDPARKADEIYQKFLGKPIYKDFVSGLGRGFGDLSDLFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S050</accession>
    <name>A1S050_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753095.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78830">
        <property type="protein sequence ID" value="ABL78830"/>
        <property type="gene ID" value="Tpen_1433"/>
    </dbReference>
    <dbReference type="GeneID" id="4601363"/>
    <dbReference type="KEGG" id="tpe:Tpen_1433"/>
    <dbReference type="eggNOG" id="arCOG01205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159724_1_0_2"/>
    <dbReference type="OMA" id="GANFIRA"/>
    <dbReference type="OrthoDB" id="122104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14927" checksum="147C13AF407114CD" modified="2007-02-06" version="1">MSRADAYVDFVREKMRLLSRFRELAPSVLSVVKRVLSEYGVDDEIFFFGSIVDGKYTAASDVDIAVVVREVPRNRSEIAGKIVEELEKIGVPSWFPLEIHFLTPDLFEALRRGGANFVRAEDFVGTANGANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S072</accession>
    <name>A1S072_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="6">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753117.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1455"/>
    <dbReference type="EnsemblBacteria" id="ABL78852">
        <property type="protein sequence ID" value="ABL78852"/>
        <property type="gene ID" value="Tpen_1455"/>
    </dbReference>
    <dbReference type="GeneID" id="4600581"/>
    <dbReference type="KEGG" id="tpe:Tpen_1455"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="CSGKTSH"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="10">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="290" mass="31927" checksum="10AA35AB74EE5E89" modified="2007-02-06" version="1">MKLLVSLKDLGTYAKNTWCPGCGNFGIERAAKTAFAELINEGVVNREDIVVVAGIGCHDKIVDYINLNSFRSLHGRAITVATGIKIANPRLQVVVFVGDGDAYGEGLEHLVFAAKRNIGIKVIVHDNRVYGLTTGQYTPTSPKGFPGRSTPKGSVEDPLNPVKLLLASGASFVARGYSARPDHLKGLIKQAIMHRGFAVIDVLQPCVTFFDTYKYYNARVYDLQEAGHDYTSYEAAMRKAEEWNYGVDDSGRIPIGIFYKAEKPTYEETILKGKNLLSREPPSIKEALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S081</accession>
    <name>A1S081_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753126.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78861">
        <property type="protein sequence ID" value="ABL78861"/>
        <property type="gene ID" value="Tpen_1464"/>
    </dbReference>
    <dbReference type="GeneID" id="4601582"/>
    <dbReference type="KEGG" id="tpe:Tpen_1464"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_9_0_2"/>
    <dbReference type="OMA" id="ERPMYAY"/>
    <dbReference type="OrthoDB" id="105754at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="116" mass="13432" checksum="FED1D2787A644FD3" modified="2007-02-06" version="1">MEVDSKPMRRLREKTGVENLWLYVLAELAKGDCYPYALRRAVLEDFGVDAGKVVFYVVTGKLEAEGFIEGYYRDRRKYYRITERGRRLLKEGIAYLRTLADRLERVSEGGAARCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1S092</accession>
    <name>A1S092_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753137.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1475"/>
    <dbReference type="EnsemblBacteria" id="ABL78872">
        <property type="protein sequence ID" value="ABL78872"/>
        <property type="gene ID" value="Tpen_1475"/>
    </dbReference>
    <dbReference type="GeneID" id="4601576"/>
    <dbReference type="KEGG" id="tpe:Tpen_1475"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="ICGFDVQ"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="293" mass="32425" checksum="604BD425435E8746" modified="2007-02-06" version="1">MNALEAEGLVKRFGNVEALRGVSLEARKGELLVLAGPNGAGKTTTVRIFTTNLRPDAGEARVLGYDVVREYREVRRRIAYIPQGFEPFWEHTPEEYVTAVLMMRGWSFWEARAQAKRWLDALGLSDARRPIRVLSGGQVRRAVVAAVLATEAEVLFLDEPTEGLDVEVRREVWRALRERLRDGSSILMTTHDMGEAEVVADRVALINSGVVLCQESPRALVEKVPYRYRAVVKKGSPLPADAVDLGDRAIVYFRSRSELGEFVSSLSDPGLLVSAGSVGLEDAYLFLLRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B8</accession>
    <name>A1S0B8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753163.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1501"/>
    <dbReference type="EnsemblBacteria" id="ABL78898">
        <property type="protein sequence ID" value="ABL78898"/>
        <property type="gene ID" value="Tpen_1501"/>
    </dbReference>
    <dbReference type="GeneID" id="4601202"/>
    <dbReference type="KEGG" id="tpe:Tpen_1501"/>
    <dbReference type="eggNOG" id="arCOG03722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115256_4_0_2"/>
    <dbReference type="OMA" id="WGACALA"/>
    <dbReference type="OrthoDB" id="102417at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="162" mass="18190" checksum="85D048CE869D3188" modified="2007-02-06" version="1">MSETVVLPRAVVEEIAKRASALGVSTDEYLADSVLRFLDPEVASEKYLEASLRLLQQAREELSKGDLRQAGEKVWGACALAIKAYALATEGRRLESHAELWVYKDRVARRLGGWVRVAFMLASSMHVNFYEGLATREDVEDALREVERLVKAVAEALRNLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C6</accession>
    <name>A1S0C6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1509"/>
    <dbReference type="EnsemblBacteria" id="ABL78906">
        <property type="protein sequence ID" value="ABL78906"/>
        <property type="gene ID" value="Tpen_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1509"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942053_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="292" mass="31694" checksum="294D554D110DDE9D" modified="2007-02-06" version="1">MKSRTMEKRAFLALLLLLSSLYVAGLYRSEAQPPALVVLSGSATLKSSSSSNGTHLYVLSVRVPPLSKLSEETIACVYNAGIASAKASLGVVEVRGGGDYACLTYTFDNRGLGYVEDTVSLVVVEPPRAASPPVAEVAVAVAAVAATSYLTLTESGRQKLFAALSAPVAYYVAKREDVLRSEKRVRILEYLKQNPGASMRRISRETGVSFGEVQWHLSILERLGYVQRVRIGKYTVYYPTGVPAERWLACFAERELGLKVKPGALEKALPSLEEYLAFRQIPLEALRSALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G2</accession>
    <name>A1S0G2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753207.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1546"/>
    <dbReference type="EnsemblBacteria" id="ABL78942">
        <property type="protein sequence ID" value="ABL78942"/>
        <property type="gene ID" value="Tpen_1546"/>
    </dbReference>
    <dbReference type="GeneID" id="4600839"/>
    <dbReference type="KEGG" id="tpe:Tpen_1546"/>
    <dbReference type="eggNOG" id="arCOG10919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_856913_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="324" mass="36832" checksum="A48AA169C6ABA202" modified="2007-02-06" version="1">MRTATSEGKARLVRVDTPVEGVVLYRVVREDLPRNQYIMVCDEVLEIHTKPWLCGEKLHELAREVAVKFLKVLYHELPLRGVPLSRLCELTIMSGGMYYMIDEAFKDVFGRSLQRCIVGAKRYPMGDGAWDVDISYENFEALPDRAIVIVGDTIATGATLSGSLLRLKQAALEKGYRVDKVAVLTISGAVEGSRRLRKVEEEFRKTWKDFELYVFNCCALFGLEPNGTDMPYGHPDTIAPEDVVSTVNERLTPQLARRLCSIFDWGDRTKNPEKHLRELVELAERLRHECSDDGCLKVLDIIKAKASEELKARMNPVALRHRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H2</accession>
    <name>A1S0H2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753217.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1556"/>
    <dbReference type="EnsemblBacteria" id="ABL78952">
        <property type="protein sequence ID" value="ABL78952"/>
        <property type="gene ID" value="Tpen_1556"/>
    </dbReference>
    <dbReference type="GeneID" id="4600905"/>
    <dbReference type="KEGG" id="tpe:Tpen_1556"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079549_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="13069" checksum="E0B5C45A411877AD" modified="2007-02-06" version="1">MLLASSSEEAVPDRFEEAKKRFLQALRDLKATRDSSATDSYEWACFQAQQAAGKAVRALLYALTPSAWGHSVVDLATLRGYEDVSEDLYIVARARARSAYRKAGRAWIRPLESRAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I3</accession>
    <name>A1S0I3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1568"/>
    <dbReference type="EnsemblBacteria" id="ABL78963">
        <property type="protein sequence ID" value="ABL78963"/>
        <property type="gene ID" value="Tpen_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1568"/>
    <dbReference type="eggNOG" id="arCOG04029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830687_0_0_2"/>
    <dbReference type="OMA" id="WRTHRTL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="140" mass="15426" checksum="EF55E3AD35EB5402" modified="2007-02-06" version="1">MGRVYVPVGCWEYGRGRVYGYPQVRLKLINLLGEELELELPVDTGFEGSLLLDRETYEFFAVGELPREAWRTHRTLAGPLPMRAARAVAVIGGEKREVLVETPVYGLGKRLVGRELLNSLTLVLDGPRGLSCLAEPTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N3</accession>
    <name>A1S0N3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753278.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1618"/>
    <dbReference type="EnsemblBacteria" id="ABL79013">
        <property type="protein sequence ID" value="ABL79013"/>
        <property type="gene ID" value="Tpen_1618"/>
    </dbReference>
    <dbReference type="GeneID" id="4601910"/>
    <dbReference type="KEGG" id="tpe:Tpen_1618"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_2"/>
    <dbReference type="OMA" id="WYAYAMI"/>
    <dbReference type="OrthoDB" id="42250at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="283" mass="32036" checksum="32D5003E5302A0D9" modified="2007-02-06" version="1">MKHSKLLSQWLYVVPTLTLIIIIFIIPIGYNVWLSFQEKSLGGEAVFIGLKNYQRLLSSASFYKSVVNSVIYTFTSVFFKALIGLGVALLLNKKFWGRGFLRGFSILPWAFPSFVVAVLFWFNYDYRGTFNTVLKLMGLQPVHWMSYDMAMASVILINIWHGWPFFFMGYLAGLQAIPEELYEAAEIDGASALQKFIHVTIPQLKPVLYTVALLSTMWTLGEFTQIYMTTGGGPVDATTTIPIATFKIAFMTEINFPLAAAYTILVLPIYLVLIYFTLKQMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P0</accession>
    <name>A1S0P0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1625"/>
    <dbReference type="EnsemblBacteria" id="ABL79020">
        <property type="protein sequence ID" value="ABL79020"/>
        <property type="gene ID" value="Tpen_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1625"/>
    <dbReference type="eggNOG" id="arCOG09701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065753_0_0_2"/>
    <dbReference type="OMA" id="YWETIPP"/>
    <dbReference type="OrthoDB" id="74172at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="27220" checksum="E3304837CA022763" modified="2007-02-06" version="1">MDITLPGFNVLVDVKGDTSGVALSLAGNQWFVVDELVHYLNSLGFTVYVETIPPGLVRERALGKALRVGALTVNLRPEIVSLPPQMLAGIPTVDTFEYAESEVAVAYQGKPVEDLCDIRNRRVAIPNPVTEGIGALLRDMYSEACGDYLELITKGSVYLTRIHHREIPELMRHGVVDAGVMWVTEARYWGLPYFAPSTGRRGKLVFALLPWATDKARQLFRQLRSQKVKEIYEKYGFKWIAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q2</accession>
    <name>A1S0Q2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1637"/>
    <dbReference type="EnsemblBacteria" id="ABL79032">
        <property type="protein sequence ID" value="ABL79032"/>
        <property type="gene ID" value="Tpen_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1637"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_3_2"/>
    <dbReference type="OMA" id="WPGMGTF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="341" mass="37771" checksum="53603B07FEF9F717" modified="2007-02-06" version="1">MGLKEYVLYRVLLTPVMLFVLLSFVFILMRVLPGDPITMLEGKNIPEEVLARRRAELGLDKPLYVQYFDYLYSLFVKRDLGETALERIPVAYLVASRLPATIELTVAATLIAAALGIALGLLSARYQYTGVQYFARFYSSVVYSVPVFYLGLLLQAYLAKPLGFPTTGRLSPVNMVAVDSLPVRTGFVFIDSLAAGRLDILLDYLAHISLPALTLGVYLSGVFSRVTYLSVEDAMSQDYTQAARGRGIREWTVVKRYGLRNALIPILTMTGLQVAALLGGAVLTETTFNWEGVGLLVYEGILKRDYAIVQGAVTIYAVLVTLTSLVVDVLYAYVDPRVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q4</accession>
    <name>A1S0Q4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753299.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1639"/>
    <dbReference type="EnsemblBacteria" id="ABL79034">
        <property type="protein sequence ID" value="ABL79034"/>
        <property type="gene ID" value="Tpen_1639"/>
    </dbReference>
    <dbReference type="GeneID" id="4600918"/>
    <dbReference type="KEGG" id="tpe:Tpen_1639"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_0_2_2"/>
    <dbReference type="OMA" id="LMNIVWP"/>
    <dbReference type="OrthoDB" id="117944at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="390" mass="40670" checksum="F6D4F5A1F5C331FF" modified="2007-02-06" version="1">MLSELNTNLKLLAALYVIFSLANGLLAVVMPPYLLHLGFTGAEAGLLLAVMNLAMIAGMVPFSYVADLKGRKPLAIAAFALALPAGLALYSANKAAVFAAYLLNGLANSMAVVSLNPLVADSAGRREVMEKAFTALQVLSLVSSSAGMLVAAAYPSLGAADRVSAYRSMILYAYLGLLAGLVPLLGVREEYRPGPRNGLRLSFSKVSLELALLAALTGLGAGIGVWNSGYYFSKKFGVEAFELGIRGVAENALLAAATLLAPLASRRLGTLGAVVAFQLASVPLLAATALSPSFVYAAAFFTARSMLMNAANPLLSALQMSLVEEGERARLSMLLTLAFQLPGSIGSAIGGYLMDVQIDLPIYLTSAVYAVQTALLYTLLKPHLAQSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R1</accession>
    <name>A1S0R1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753306.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1646"/>
    <dbReference type="EnsemblBacteria" id="ABL79041">
        <property type="protein sequence ID" value="ABL79041"/>
        <property type="gene ID" value="Tpen_1646"/>
    </dbReference>
    <dbReference type="GeneID" id="4601660"/>
    <dbReference type="KEGG" id="tpe:Tpen_1646"/>
    <dbReference type="eggNOG" id="arCOG04032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701362_0_0_2"/>
    <dbReference type="OMA" id="WDIDSEI"/>
    <dbReference type="OrthoDB" id="62671at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="393" mass="44295" checksum="2D3756DBB9FB6AF6" modified="2007-02-06" version="1">MLDPLEYLLRPSVLGEMSDFLKGRWVAVHCSRKMKDGRQLLVRYAGGSPLKASSPAELAALLRRLGRLGPRAVYGTANVYAKLETREDALNYSGNVLRRTVTWDIDSLPEHWRATIEAARAIVDYLEREGVVKSVWLKWSGRGMHVHLHEYAVTSEVIEKHGVLDATWSLAQLVLEEVKEKIREVNAKHGSKIKVENLMDPQRVFTAPLSLHRALDVACVALKPEQLDDFEPSWTNPESPVHNPSWRAYEEGEADHLAEKAVGRIGGYLGKPRAQPVAPRAPVPVLENPSGSLAEVRLRFNPYPGPLKGRKLYLDPMKAVRLLEDVLSHYVLGNIGLEEAVRYLEATRTVTLKAQGYSKADLELLEKLYDEAVRVLLQKSREEVEEWLRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R3</accession>
    <name>A1S0R3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753308.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1648"/>
    <dbReference type="EnsemblBacteria" id="ABL79043">
        <property type="protein sequence ID" value="ABL79043"/>
        <property type="gene ID" value="Tpen_1648"/>
    </dbReference>
    <dbReference type="GeneID" id="4601661"/>
    <dbReference type="KEGG" id="tpe:Tpen_1648"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_2_2"/>
    <dbReference type="OMA" id="FVKVNYP"/>
    <dbReference type="OrthoDB" id="36379at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="272" mass="29485" checksum="8D50F1452ED57389" modified="2007-02-06" version="1">MGYGYIGKRVRLGRILRDGKAVVFAFDHGVEHGPGDFPGETVNPRKILSKVVGEVDAVMMLPGIAALTSEVWQGKVPLIVKVTSKTSLRPEAEKLLQSPFGFVEDAVALGADAVAATVYWGSNFEDLMLERWFQVKRAAETYGLPCLQLSYPRGPAIKNMYDVEVVRYGVRAAIESGADLIKTYYTGSTESFRRVVEVAAGVPVLMSGGAKARTLLDFLYVVKSVMDAGAQGVVVGRNIFQHEDPTLAAKAIMYVVHEGYAPEEALRKAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V6</accession>
    <name>A1S0V6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753351.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1691"/>
    <dbReference type="EnsemblBacteria" id="ABL79086">
        <property type="protein sequence ID" value="ABL79086"/>
        <property type="gene ID" value="Tpen_1691"/>
    </dbReference>
    <dbReference type="GeneID" id="4601014"/>
    <dbReference type="KEGG" id="tpe:Tpen_1691"/>
    <dbReference type="eggNOG" id="arCOG01204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_0_2"/>
    <dbReference type="OMA" id="EPDTIHI"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="130" mass="14922" checksum="69E818E0F9DD2265" modified="2007-02-06" version="1">MNTLSDVVERLKNRFKVYAVILFGSRARGDWKPWSDYDLLVIGDFDKDYLDRIGEVLDALRDVRLPVEPHPYTLSEALEMVEKGNPLIISALEEGVVLHSTGEFEKLVKAFEELKKKGLEKTRTSYKLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W6</accession>
    <name>A1S0W6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753361.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79096">
        <property type="protein sequence ID" value="ABL79096"/>
        <property type="gene ID" value="Tpen_1701"/>
    </dbReference>
    <dbReference type="GeneID" id="58787009"/>
    <dbReference type="KEGG" id="tpe:Tpen_1701"/>
    <dbReference type="eggNOG" id="arCOG03745">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519954_0_0_2"/>
    <dbReference type="OrthoDB" id="108657at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="84" mass="9141" checksum="BDB426682DA239EC" modified="2007-02-06" version="1">MAEVEVKGRKWPVLVAEVDAPVPLLGVYALETLGLRVNPTTGELEEVSPEGGYLLVAGLMLSCLKLTFSHLRRIKAKTASYSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z3</accession>
    <name>A1S0Z3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753388.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1728"/>
    <dbReference type="EnsemblBacteria" id="ABL79123">
        <property type="protein sequence ID" value="ABL79123"/>
        <property type="gene ID" value="Tpen_1728"/>
    </dbReference>
    <dbReference type="GeneID" id="4601753"/>
    <dbReference type="KEGG" id="tpe:Tpen_1728"/>
    <dbReference type="eggNOG" id="arCOG07752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569413_0_0_2"/>
    <dbReference type="OrthoDB" id="134035at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="479" mass="52549" checksum="3390B938B6B20FB4" modified="2007-02-06" version="1">MSRRNAVLSALIPALVRTIPEILSWPYTVGFDPVGIYAVNAYQGVFLSMGIPQLFKTTSLYFLIVTLAYKALGDPILAVKLLAPILNGLLGYTVYRYARSTGLGEKASLAAALISTTYFVGLRISWEMHRQMLATAMLLAYMELDKKPGRAAAAAQAALAFLIGWTHEFITVILAAVAAARLLSSKTPREALRAFTALPAGALLLYQVYTPETGALAVPAERLAGVDPAYMLAYATGFLAYLYAPLLPLLAYGASTLRDRGTLAWTATCLAMTYSFLTGTTVLWFRWAILLNYPASLAAGAGLEKLLEKPGRARKAALALVAVYASMTATYIALPPEQQFNKYFGDWNIYKHYMQTSMLQNTLPLSDTPSAIQAVKWVDTLPGNKTLVLHEAFHSWAALYAKNSKLIRVGEHMLSAPNQYRPNTAEEILRAARREAATGAKVYTIWWVAGKGWYNMPNPPPGFKEVKRFGEIAVYEYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S111</accession>
    <name>A1S111_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1746"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79141">
        <property type="protein sequence ID" value="ABL79141"/>
        <property type="gene ID" value="Tpen_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1746"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848879_0_0_2"/>
    <dbReference type="OMA" id="VHAHNVP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="173"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="346" mass="37293" checksum="3808FC4F96768BFE" modified="2007-02-06" version="1">METFRLLVVSPRVSGLGGVAQHVGKLVELLRRDGHEVEVVSAENTPILPVKGLMNPSFAATSALKVALGRLKGRRYDVVHAHNVPSAPAMRAARGGRVLTLHGVFSEQVGYLHGGLLGRLSGVAERVALGWADRVTSVSRATAEHYSRIGVNVVHVPNAVDPSDLPGEGERMYERQVVYSGRLSREKGVDLLVKAFRALDVDAHLVVVGGGPLEEELRSLAGGDPRIHFLGPMPRERALRVVKGSDVFVLPSRYEGLSTALLEAMAMGVPVVATKVGGNTELVEDGKTGLLVEPSPEEVARAVRLLLEDSDLAARLASAAKRVVAEKYSWDKVYAQYLDVYREVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S143</accession>
    <name>A1S143_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753438.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1778"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79173">
        <property type="protein sequence ID" value="ABL79173"/>
        <property type="gene ID" value="Tpen_1778"/>
    </dbReference>
    <dbReference type="GeneID" id="4601939"/>
    <dbReference type="KEGG" id="tpe:Tpen_1778"/>
    <dbReference type="eggNOG" id="arCOG01421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552792_0_0_2"/>
    <dbReference type="OMA" id="GWEACGT"/>
    <dbReference type="OrthoDB" id="19755at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="516" mass="58663" checksum="83767D27C0D13046" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S156</accession>
    <name>A1S156_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1791"/>
    <dbReference type="EnsemblBacteria" id="ABL79186">
        <property type="protein sequence ID" value="ABL79186"/>
        <property type="gene ID" value="Tpen_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1791"/>
    <dbReference type="eggNOG" id="arCOG04295">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060471_4_1_2"/>
    <dbReference type="OMA" id="IEVEPYF"/>
    <dbReference type="OrthoDB" id="101519at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="183" mass="20525" checksum="E30EB33CA5DB93C0" modified="2007-02-06" version="1">MEREFFARQPDAVARMLLGKLLVRRLEGGVRAGIIIEVEPYFGAEDPASRARRGGDLARVMCGEVCTALVYGVHRQWLLNVVAHEPGLCGAILIRGILPVDPGTLKPLGREVLGPGRVTRYFSVDKALHRTYLCDEDSPLRILDGLTFDDECISRSPRVGVREDLPIPLNFRIRRECLTREDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1S189</accession>
    <name>A1S189_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dihydrolipoamide dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753484.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1824"/>
    <dbReference type="EnsemblBacteria" id="ABL79219">
        <property type="protein sequence ID" value="ABL79219"/>
        <property type="gene ID" value="Tpen_1824"/>
    </dbReference>
    <dbReference type="GeneID" id="4602061"/>
    <dbReference type="KEGG" id="tpe:Tpen_1824"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_2"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="9">
        <location>
            <begin position="345"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL79219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="469" mass="53056" checksum="D3FF43D5EB353D5B" modified="2007-02-06" version="1">MVKHYDVIVFGTGSAMNIVSELINEGKRLRFAVIENNMVGGICLTRGCIPSKMLLEVARNIRRIKEAEKFGIQVSLAGVDFTGVMERVWRRIYAESKEIEHSLKHHPLIDLYQVDGTFVGDYTVDVGGREIEGDTILLCTGSRPHVVKAPGVEEVKYYTNDNFFRELRKLPRRTVVIGGGFVGLELGFFLAMMGSQVTVLQRRERILPEEEPEISELLARDLSRYMDIRTLHEVVEFRRSGERQIVVAENKATGDNVEFEADAILMAAGRESYSDITRPEKTGVKTDEKGWILVDEYLRTTKDGVWAFGDATGKMMFKHKANYESVIVYRNAFRGENVKARYHAVPHAVFTEPEVASVGLKEEEAAKKYDILVGIAGYEETAKGEAMMLHDYFVKVILDRDTFRILGAHIIGPEASILIQEIVNLMYAGDGTAEPIYEGMHIHPALSEVVERAFFHLHEPGEWRRHAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A8</accession>
    <name>A1S1A8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1843"/>
    <dbReference type="EnsemblBacteria" id="ABL79238">
        <property type="protein sequence ID" value="ABL79238"/>
        <property type="gene ID" value="Tpen_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1843"/>
    <dbReference type="HOGENOM" id="CLU_1451480_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="186" mass="19659" checksum="EA4CBA8635265DFE" modified="2007-02-06" version="1">MDLDRAIKTVGLVNAVLTTVLITLWVIAAFRSVVVTAEVAGIPLVPPLAATQPSPETVGKAIISLLYTVFKYVIYAVIVITGIYVALGLVANFVTAFLPITVPRATLNTLIKNILALFIIKLVVDASLSYFGYSADVAENMAVLEGVGGAPSLLLIAAMVTGVAVAVYLVYRALKKRLGEVEVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D6</accession>
    <name>A1S1D6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751391.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1871"/>
    <dbReference type="EnsemblBacteria" id="ABL79266">
        <property type="protein sequence ID" value="ABL79266"/>
        <property type="gene ID" value="Tpen_1871"/>
    </dbReference>
    <dbReference type="GeneID" id="4600336"/>
    <dbReference type="KEGG" id="tpe:Tpen_1871"/>
    <dbReference type="HOGENOM" id="CLU_2550476_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="82" mass="9857" checksum="8ECCC509E46CD6B5" modified="2007-02-06" version="1">MSERRKEVVDRYLADSSYFSDYWREEVAEFWDYPLLSTLALSEDWVHLERELEKIGRAASERAAKRLVKEIREDFELEVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E1</accession>
    <name>A1S1E1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751396.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79271">
        <property type="protein sequence ID" value="ABL79271"/>
        <property type="gene ID" value="Tpen_1876"/>
    </dbReference>
    <dbReference type="GeneID" id="4600332"/>
    <dbReference type="KEGG" id="tpe:Tpen_1876"/>
    <dbReference type="HOGENOM" id="CLU_1881181_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="15756" checksum="939C0F9ABB63B19A" modified="2007-02-06" version="1">MVYEKFADKIKDASRAVLKHTFLDMLVHTIREVNDVNVPVLIDEIEELQKKAEEEGLQAWVDFLGALKALVCAYGFKNTILVRASYMEQYYRMIRALETDGFESEYCEFLTWLGTSFEHTFPPIEKIARERGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E2</accession>
    <name>A1S1E2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751397.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1877"/>
    <dbReference type="EnsemblBacteria" id="ABL79272">
        <property type="protein sequence ID" value="ABL79272"/>
        <property type="gene ID" value="Tpen_1877"/>
    </dbReference>
    <dbReference type="GeneID" id="4600314"/>
    <dbReference type="KEGG" id="tpe:Tpen_1877"/>
    <dbReference type="HOGENOM" id="CLU_1691626_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="155" mass="18536" checksum="4ED4D213A734DB21" modified="2007-02-06" version="1">MSVTTTVEKTREQIKRVRELYRGAQLKKVDSPVRYVRVYLAAPEHIYDYVLTFGHDYAEDKTFAIVHLREIWEGEFFEDIIEEHDELKVWEGAEGDGVILWFLGYVGEVIELWSDLDIHVMVEFHEDFEDIVNYYLGAEEDWEEEEEDWEGFCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F2</accession>
    <name>A1S1F2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751407.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1887"/>
    <dbReference type="EnsemblBacteria" id="ABL79282">
        <property type="protein sequence ID" value="ABL79282"/>
        <property type="gene ID" value="Tpen_1887"/>
    </dbReference>
    <dbReference type="GeneID" id="4600321"/>
    <dbReference type="KEGG" id="tpe:Tpen_1887"/>
    <dbReference type="HOGENOM" id="CLU_1615394_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="164" mass="18313" checksum="4BDBF436868A4219" modified="2007-02-06" version="1">MISPIILLLLIWLGTSIGIVFVTLNEYIKENGKLDVAAALFALRELSAIALQFIWLIVLLHVWGFLDIRTELGWTAQIPDLSTPQGQAAYVFIFASLVIIAILYAEGYVNLAFTVAVFSGVAMLGYIDANVYLQLLGIGVAMLAVFAYVFRSELEEELRRWKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F4</accession>
    <name>A1S1F4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751409.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1889"/>
    <dbReference type="EnsemblBacteria" id="ABL79284">
        <property type="protein sequence ID" value="ABL79284"/>
        <property type="gene ID" value="Tpen_1889"/>
    </dbReference>
    <dbReference type="GeneID" id="4600309"/>
    <dbReference type="KEGG" id="tpe:Tpen_1889"/>
    <dbReference type="HOGENOM" id="CLU_1709236_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="153" mass="17335" checksum="4946C3DB01B5EF2D" modified="2007-02-06" version="1">MPKPPSGKVYVVVGSECPHCKYALENSYSFRALWRSHAERLSIDVEDELQLVTAFYLYLSERERLERIAEGGLRTVAGVKTPTVIVSMPEHIRVLPGLPPDMDETKIHVALSSLLYGTDVRLPLRPRKPEKERGEEEEEAKPKKKGRGGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW44</accession>
    <name>A1RW44_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751689.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0014"/>
    <dbReference type="EnsemblBacteria" id="ABL77424">
        <property type="protein sequence ID" value="ABL77424"/>
        <property type="gene ID" value="Tpen_0014"/>
    </dbReference>
    <dbReference type="GeneID" id="4601060"/>
    <dbReference type="KEGG" id="tpe:Tpen_0014"/>
    <dbReference type="eggNOG" id="arCOG00193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="QSIVTFP"/>
    <dbReference type="OrthoDB" id="64935at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="245" mass="27383" checksum="1A23FD652992D69B" modified="2007-02-06" version="1">MQTILSIRNIVKTFKEGGKTLPVLDHISFDVGEEFVAILGPSGCGKTTLLRIIAGLEKADSGEIVFARGDSRIGFIFQSPTLLPWLTVLENVALPLRANGVPRREAEEKARKYISLVGLQAFENFYPHELSGGMKQRVNIARALAVEPVLLLMDEPFSQLDPLTAESLRSEILDMWMWGVTTVRAIIMVTHNVDEAVFMADRIIVLTTRPAKIAGIVHVDLPRPRDRRSPEFQKVEDQVYEYISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW49</accession>
    <name>A1RW49_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0019"/>
    <dbReference type="EnsemblBacteria" id="ABL77429">
        <property type="protein sequence ID" value="ABL77429"/>
        <property type="gene ID" value="Tpen_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0019"/>
    <dbReference type="HOGENOM" id="CLU_1207672_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="229" mass="26099" checksum="53BADD91CE4837E0" modified="2007-02-06" version="1">MGDGERRPSKFVSSRRIRAFFTREGDVLYLDLDGETYSGVGDFVPIPVGKLRGLRLEEIPEGVSIEPVEYMEKNIFYILRMGSLFTYEVKVNRGGVEVSVDEWFSEWRSYIGIEAYQEALLSVLKELMDSGFVSYVDLESGEEMLYVSFVVPLPGSLTVFKALKVVRRLVRELELEVTRRASILALREAKRKLRRIAERGLEESFLERVSRIFYSGVGGGEEGISKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW61</accession>
    <name>A1RW61_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751706.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0031"/>
    <dbReference type="EnsemblBacteria" id="ABL77441">
        <property type="protein sequence ID" value="ABL77441"/>
        <property type="gene ID" value="Tpen_0031"/>
    </dbReference>
    <dbReference type="GeneID" id="4601777"/>
    <dbReference type="KEGG" id="tpe:Tpen_0031"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="EPIKVFN"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="308" mass="33868" checksum="739C7A14320209C9" modified="2007-02-06" version="1">MNVGITGGAGFIGFNTARYLASRGFQVVVLDDFSRATVGREDLEKVGAEVYEGDVRDAEALRRFLSGVDAVIHLAALVDVRESEERPEEYWSVNVEGTRALLAEASRAGVRKVVFASSAAVYGDLGGLTAGEEVDARPKSFYGLTKRVGEELCRFFSGRGVVCVALRIFNVYGEYSRRGVIYEFARRVLSGLPVKVYGDGNQTRDFVYVGDVARAFEAVIAEWSGGFEVFNVASGRCVSVNELVRLFEQVTGKRVGVLREPARPEEIRRSCASTEKAARMLGFRASTSLEEGVRRVVEWVARYAEDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW68</accession>
    <name>A1RW68_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751713.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0038"/>
    <dbReference type="EnsemblBacteria" id="ABL77448">
        <property type="protein sequence ID" value="ABL77448"/>
        <property type="gene ID" value="Tpen_0038"/>
    </dbReference>
    <dbReference type="GeneID" id="4601274"/>
    <dbReference type="KEGG" id="tpe:Tpen_0038"/>
    <dbReference type="eggNOG" id="arCOG01723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_2_0_2"/>
    <dbReference type="OMA" id="QHPCRDF"/>
    <dbReference type="OrthoDB" id="123503at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="180" mass="20489" checksum="8AC321A07C878B72" modified="2007-02-06" version="1">MPREVEVKFRVEGHDVLRRKLREAGAAYVDTVDQVDIYFQHPCRDFASTDEALRLRVNYSGSGSYAELTYKGPKEGGWAKNREEIVARVEAAEALRKILERLGFSEVATLRKHREFYVLDGTEVSLDYVEGLGFFVEIEDKGGGVEALREVVSRLGLTGEPLPKTYLELYLEEKATRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW84</accession>
    <name>A1RW84_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0054"/>
    <dbReference type="EnsemblBacteria" id="ABL77464">
        <property type="protein sequence ID" value="ABL77464"/>
        <property type="gene ID" value="Tpen_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0054"/>
    <dbReference type="eggNOG" id="arCOG06945">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2243994_0_0_2"/>
    <dbReference type="OMA" id="IWEPVKE"/>
    <dbReference type="OrthoDB" id="119057at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="130" mass="14451" checksum="C10421FE6E27810B" modified="2007-02-06" version="1">MSSPLGLFFSFCALGIFTCVFFVFSMSETIEFELVRPVNPAGVSFIKYLWGAIGARNRSLLEDRERRGELTRLIQKLGFALEEKVGGNKLVTGRVVLTLENGRPVRLALRDVKVWAETGALEGEVAVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW93</accession>
    <name>A1RW93_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0063"/>
    <dbReference type="EnsemblBacteria" id="ABL77473">
        <property type="protein sequence ID" value="ABL77473"/>
        <property type="gene ID" value="Tpen_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0063"/>
    <dbReference type="eggNOG" id="arCOG00299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130790_0_0_2"/>
    <dbReference type="OMA" id="EAEHVNM"/>
    <dbReference type="OrthoDB" id="96883at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="16185" checksum="07288A9E23B5FCA1" modified="2007-02-06" version="1">MGVCPRRLTEFNVAGKEIREKRKLLVYGSCLAYEYPELLREYSEGRVDLAVCLEAEHFNVVALKLASMLARVDVEEVVVLTVDGSPHCVQLHHAVEEAKKVTGRSPRTRHLVIEEGKVVEVDEKAVKTARYLSRVQRLLDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC4</accession>
    <name>A1RWC4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751769.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0094"/>
    <dbReference type="EnsemblBacteria" id="ABL77504">
        <property type="protein sequence ID" value="ABL77504"/>
        <property type="gene ID" value="Tpen_0094"/>
    </dbReference>
    <dbReference type="GeneID" id="4601386"/>
    <dbReference type="KEGG" id="tpe:Tpen_0094"/>
    <dbReference type="eggNOG" id="arCOG00707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="AHHKDAW"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="614" mass="67752" checksum="972AEE89DEB412D3" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC8</accession>
    <name>RIFK_THEPD</name>
    <protein>
        <recommendedName>
            <fullName>Riboflavin kinase</fullName>
            <shortName>RFK</shortName>
            <ecNumber>2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ribK</name>
        <name type="ordered locus">Tpen_0098</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751773.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWC8"/>
    <dbReference type="SMR" id="A1RWC8"/>
    <dbReference type="STRING" id="368408.Tpen_0098"/>
    <dbReference type="EnsemblBacteria" id="ABL77508">
        <property type="protein sequence ID" value="ABL77508"/>
        <property type="gene ID" value="Tpen_0098"/>
    </dbReference>
    <dbReference type="GeneID" id="4602014"/>
    <dbReference type="KEGG" id="tpe:Tpen_0098"/>
    <dbReference type="eggNOG" id="arCOG01904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088476_0_0_2"/>
    <dbReference type="OMA" id="AYYVRQY"/>
    <dbReference type="OrthoDB" id="91297at2157"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000322107" description="Riboflavin kinase">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="H-T-H motif-like">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Riboflavin kinase">
        <location>
            <begin position="93"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="102"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="227" mass="25939" checksum="3944F9974A920F75" modified="2007-02-06" version="1">MSKDYEVFPLLLEMAKRGCLVAPRRLSRIEILKTLGLTPWRFKKLVEAAEEEGYIERRVHGRMVFYVVTERGRALLRRVYDDLKRTIDSSTFLTLRGYVVPGLGEGAIYMGIPRYVEAFKEVLGYEPYPGTLNIKLVDEDVYLRRALREKRVGFRIEGFRLDEGRESCGVTVYKAMIMANGVTVSGAALDIDKTKHGDEILELIAPVRLRDELRLKDGDKVEVVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI2</accession>
    <name>A1RWI2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0152"/>
    <dbReference type="EnsemblBacteria" id="ABL77562">
        <property type="protein sequence ID" value="ABL77562"/>
        <property type="gene ID" value="Tpen_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0152"/>
    <dbReference type="eggNOG" id="arCOG04306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088484_0_0_2"/>
    <dbReference type="OMA" id="WMASERI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="203" mass="22054" checksum="CE4F46319819F641" modified="2007-02-06" version="1">MTRGVWVEALARLILELEGFSVEQTRLRLERNGVSLAEVDILARKNGEAYAVEVKSGRVSVTDVRQVYANAALLGAKPLLIARGFSDEAAKATAEELGVKVLLIPDYVYFVDTEELLRLVEEAVALTLEKLLSVSPANLSPPEVEVVKAIASSSSFEEAARRLGVSTDALGKAVEALREKGAITLHSPFRLLRLQCKLLLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ0</accession>
    <name>A1RWJ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylated-DNA--protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0160"/>
    <dbReference type="EnsemblBacteria" id="ABL77570">
        <property type="protein sequence ID" value="ABL77570"/>
        <property type="gene ID" value="Tpen_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0160"/>
    <dbReference type="eggNOG" id="arCOG02724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_2"/>
    <dbReference type="OMA" id="MIEHFLM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="150" mass="16729" checksum="6D5E0E1DB2E9AF3D" modified="2007-02-06" version="1">MVNIEASCFSTPIGELCGIVRGNVVLYLHRPLLLSGVTRGEFAERLRREIEEYFSGRRKSFSFRPLIRGSALRKKVFEEVLRIPYGSTITYGELAARVGSSPRAVGRVLSENRILLVIPCHRVVASKGVGGYAFGVEAKKYLLRLEASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ5</accession>
    <name>A1RWJ5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751840.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0165"/>
    <dbReference type="EnsemblBacteria" id="ABL77575">
        <property type="protein sequence ID" value="ABL77575"/>
        <property type="gene ID" value="Tpen_0165"/>
    </dbReference>
    <dbReference type="GeneID" id="4601420"/>
    <dbReference type="KEGG" id="tpe:Tpen_0165"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052321_2_0_2"/>
    <dbReference type="OMA" id="ANAMAYY"/>
    <dbReference type="OrthoDB" id="104055at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="191"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="410" mass="45731" checksum="D191B9E332A6CFB1" modified="2007-02-06" version="1">MTVKAVATIAGSAATLLVAVLAQRWFVALFSVPLLLPLFASLLYVHPSEKHIVAERVVPRSNFVAGDTVRVEISVRNVSNRSVVLEVREKLGEGLRLVGGDTVMLSVLKPHQEKRFTYYVTADRRGHYDLGPLEVYSLDPFLFTRVKVKEYGAERLTFFPKIRRIDYIPMPAARTTLLPGEAMSNAPGEGFEFMEVGEARGSGLRRINWKATAKTGRPMVNVYLGERSAECLIVLDVPSSRLLGRALTEVLVDKMVEYTGSLAYYLTRRGNRVSLLVVGHYRDWVKPGFGKRHFLRILHSLADVKSLETKTLVDYSEVFSRVAPFLAKSRSLVFIVSTFTEKAAFEILGEAERSGYVVRLVAINPFNSVAEHCEKDKLEPLKLLSDAWEYGLPRVLSRGSPRTKLLSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK6</accession>
    <name>A1RWK6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751851.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0176"/>
    <dbReference type="EnsemblBacteria" id="ABL77586">
        <property type="protein sequence ID" value="ABL77586"/>
        <property type="gene ID" value="Tpen_0176"/>
    </dbReference>
    <dbReference type="GeneID" id="4600878"/>
    <dbReference type="KEGG" id="tpe:Tpen_0176"/>
    <dbReference type="eggNOG" id="arCOG00706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="AYPISHE"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="618" mass="67322" checksum="F40B45AFC210F3EA" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL1</accession>
    <name>A1RWL1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH ubiquinone oxidoreductase, 20 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751856.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0181"/>
    <dbReference type="EnsemblBacteria" id="ABL77591">
        <property type="protein sequence ID" value="ABL77591"/>
        <property type="gene ID" value="Tpen_0181"/>
    </dbReference>
    <dbReference type="GeneID" id="4600883"/>
    <dbReference type="KEGG" id="tpe:Tpen_0181"/>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088839_0_0_2"/>
    <dbReference type="OMA" id="LRIYHAM"/>
    <dbReference type="OrthoDB" id="100307at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="245" mass="26832" checksum="AA165EC9A95B1565" modified="2007-02-06" version="1">MSRLAKQKAYDALKRSVYLLRVDSGSCNGCDIEVFDALTPYFDVERLGVKLVLSPRMADVILVTGPVTRQFLPVLKATYEAAPKPCVVVACGACACGGGIWYDTYGTAGGVDKVIPVDVYIPGCPPRPHAILHGVAVALDILEQKVKRSETKADAESFKPALPSLEGAINSWELYRALKLELYKHLGYRIGYRVLCDLLRISKGSKDLDDFAAKAEKAVSEKYHDARITEAVRLSCLKLKEVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM6</accession>
    <name>A1RWM6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ordered locus">Tpen_0196</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751871.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0196"/>
    <dbReference type="EnsemblBacteria" id="ABL77606">
        <property type="protein sequence ID" value="ABL77606"/>
        <property type="gene ID" value="Tpen_0196"/>
    </dbReference>
    <dbReference type="GeneID" id="4600805"/>
    <dbReference type="KEGG" id="tpe:Tpen_0196"/>
    <dbReference type="eggNOG" id="arCOG04180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041630_0_0_2"/>
    <dbReference type="OMA" id="YMRRHGP"/>
    <dbReference type="OrthoDB" id="21175at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="FBP binding; shared with dimeric partner" evidence="15">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABL77606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="368" mass="41139" checksum="47472C7C0312C70A" modified="2007-02-06" version="1">MRITVSLIKADVGGLAGHVVVHPKLEELARKRLEEARETGLLIDFYVYHVGDDLQLLMTHTKGENNAEIHKLAWDIFVEVTEKVSKPLKLYGAGQDLLKDTFSGNIKGMGPGCAEMEFEERRSEPILVFSADKTEPGAWNYKLYRIFADPFNTAGLIIDPAMHSGFIFEVVDVYEHKSVKLSTPEESYDLLALIGTPGRYVVKRVYRKSDGEIAAVSSATRLSLIAGRYVGKDDPVLIIRAQHGFPATGEVLEAFAFPHLVAGWMRGSHTGPLMPVPLRYAQCTRFDGPPRVVGLGFQLHDGRLEGPVDLFDDPAFEMTRRMAEEVADYMRRHGPFMPHRLGPEEMEYTTLPSVLEKLKARFVPAEAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT8</accession>
    <name>RS4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps4</name>
        <name type="ordered locus">Tpen_0258</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751933.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWT8"/>
    <dbReference type="SMR" id="A1RWT8"/>
    <dbReference type="STRING" id="368408.Tpen_0258"/>
    <dbReference type="EnsemblBacteria" id="ABL77668">
        <property type="protein sequence ID" value="ABL77668"/>
        <property type="gene ID" value="Tpen_0258"/>
    </dbReference>
    <dbReference type="GeneID" id="4601850"/>
    <dbReference type="KEGG" id="tpe:Tpen_0258"/>
    <dbReference type="eggNOG" id="arCOG04239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="OrthoDB" id="93256at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000293414" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="172" mass="19793" checksum="954749E14FE4287B" modified="2007-02-06" version="1">MGDPKKPRKKWQGPSHPWRKETLLEEMQLVGEYGLRNKRELWIAKSLLREIRAKARKLLALPAEERIKLEKPLVSRLYKMGLLPSEDASLDDVLSLTVRDVLERRLQTIVYRKGLATTIRHARQLITHGHIAVNSRRVRSPGYLVSRDEENFISYYEGSPLAKMAQGGAQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX13</accession>
    <name>A1RX13_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bis(5'nucleosyl)-tetraphosphatase, ApaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752008.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0334"/>
    <dbReference type="EnsemblBacteria" id="ABL77743">
        <property type="protein sequence ID" value="ABL77743"/>
        <property type="gene ID" value="Tpen_0334"/>
    </dbReference>
    <dbReference type="GeneID" id="4601701"/>
    <dbReference type="KEGG" id="tpe:Tpen_0334"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_10_2"/>
    <dbReference type="OMA" id="HGQFWDM"/>
    <dbReference type="OrthoDB" id="104775at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="1">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="281" mass="32341" checksum="7FFE7DF4E6DAD12D" modified="2007-02-06" version="1">MNLPEDVEILGRKYKLSLTPEELKRLLEESKKVLSSDPPLVEVKGKRVLFVGDTHGDVESTINAFREAADVYVFLGDYVDRGRYQLENIVLLLQVKRDNRERIVLLRGNHETRSMNMVYGFLRVVITRYGERMYDLFEEVFSQMSYGALVNREVLAVHGGIPKGLSRVEEIQSLKKEQEPSDPRTFQLLWNDPDEGITGFEPSPRGEGIYLFGEDVARRFLDENGLKLLVRGHEPVQEGVKFLFGERVATVFSCRYYGITPTALLLDGEERRRIRLDEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX41</accession>
    <name>A1RX41_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S30E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752036.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0362"/>
    <dbReference type="EnsemblBacteria" id="ABL77771">
        <property type="protein sequence ID" value="ABL77771"/>
        <property type="gene ID" value="Tpen_0362"/>
    </dbReference>
    <dbReference type="GeneID" id="4601491"/>
    <dbReference type="KEGG" id="tpe:Tpen_0362"/>
    <dbReference type="eggNOG" id="arCOG04293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="49" mass="5689" checksum="3368AF468EE5F364" modified="2007-02-06" version="1">MPSHGSLTKAGKVRNATPKIPPKPKKNLIPRRRNYRNYRRRILYAASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX73</accession>
    <name>A1RX73_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752068.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0394"/>
    <dbReference type="EnsemblBacteria" id="ABL77803">
        <property type="protein sequence ID" value="ABL77803"/>
        <property type="gene ID" value="Tpen_0394"/>
    </dbReference>
    <dbReference type="GeneID" id="4600529"/>
    <dbReference type="KEGG" id="tpe:Tpen_0394"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269998_0_0_2"/>
    <dbReference type="OMA" id="LGEEIRY"/>
    <dbReference type="OrthoDB" id="109201at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="217" mass="24745" checksum="77FB64E9067FF805" modified="2007-02-06" version="1">MEGLSIADVKLVSVLRKELLLSQDILEEIRRVVKTINEQGLRDEQRERIERIQKTKSQTQTLQTEYIDYLTKASRGLMHREEWVRIGSRVMSVVDKLSGISYRLGFLIEKNWVVPEKVASNFAAMCDNLSMMVSTLDQAMNKLLSSPPQALEDLRKISEYESTIDSLYRSTIFEVLGSNISSSTMLLLLGIAEMLEDSSDILYDLVSNLYIILLEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX83</accession>
    <name>A1RX83_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0404"/>
    <dbReference type="EnsemblBacteria" id="ABL77813">
        <property type="protein sequence ID" value="ABL77813"/>
        <property type="gene ID" value="Tpen_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0404"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_5_1_2"/>
    <dbReference type="OMA" id="TEGGCCW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="450" mass="49422" checksum="DFB8A66406B882DD" modified="2007-02-06" version="1">MRFTVFVEPGASEVVPALGLDFRELVGYHQKLGRLKQLQKMVELEFEAAYYMKKYQPDPVLMNTRYGRLISNVLARRETVYEVVGGKSDSEVYAKFLRAMENPQPLSRIESSTGLKEVAVDLFRLPVPKFFERDGGRYITAGVFIAKDPLTGAVNASIHRAMILDEESLAVRLVPRHLYQIHRNAEKAGRNLPAAILIGAPPLVYLCAASSPPFGVYEVEVANALAGGRLTGTDSLLDGVVLPLPVEVVLLGEFIAGRRAKEGPFVDILGTYDIVREEPVFRVESILTRQDPLFYSILPSGLEHILLMGFPREAAIWSVASRTATGVRKVRLTPGGGGWLHAVISMEKTTEGDPKNVILAAFAAHPSLKTVVVVDADVDPDDPLDVEWALATRMQPDEDIVIIKGARGSSLDPSADQVTLQTSKLGIDATRPLSKDKSLFEKARIPFTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX95</accession>
    <name>A1RX95_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-cytosine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752090.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0416"/>
    <dbReference type="REBASE" id="14207">
        <property type="entry name" value="M.TpeORF416P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77825">
        <property type="protein sequence ID" value="ABL77825"/>
        <property type="gene ID" value="Tpen_0416"/>
    </dbReference>
    <dbReference type="GeneID" id="4600494"/>
    <dbReference type="KEGG" id="tpe:Tpen_0416"/>
    <dbReference type="eggNOG" id="arCOG04157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_2_2_2"/>
    <dbReference type="OMA" id="EPFTGAN"/>
    <dbReference type="OrthoDB" id="58937at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="35772" checksum="683674A9E5F65598" modified="2007-02-06" version="1">MSSELTVLDLFAGAGGFSRGFAEEGFSIVGAVEVDPLAAEAFRLNFPGARVFEEDVREVHSRDILLGLGFRPRVIIGGPPCEAYSRANPRREREPLDRLYKDPVGSLVLHYIRIVGDLEPEVFVMENVPGILDEGLGEVLREEFSRVGYHDVYFNVLVAEHYGTPSHRVRVFISNKRISPPKTGKTITVWDAIGDLPPPDPYYEIPNHEPVTLSAGKAKRVAKLRWGEALVHYRGYGGRVLRNLVRLHPYRVAPTVMGSSRFVHPFENRLLTVREQARLMGFPDTHVFVGSKEAQFNQVGEAVPVPLARAIAREVKKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB3</accession>
    <name>A1RXB3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0434"/>
    <dbReference type="EnsemblBacteria" id="ABL77843">
        <property type="protein sequence ID" value="ABL77843"/>
        <property type="gene ID" value="Tpen_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0434"/>
    <dbReference type="eggNOG" id="arCOG14900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718313_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="152" mass="16965" checksum="A55DF93B769EEB46" modified="2007-02-06" version="1">MHCLVLSHAEKYAWRAHRMTKIVELNELMKKYTQELSDALQRKDLDSAISREIALLEALIAVAKNEIISVINDPTVKNIAESYVLSHEKTLSYARGVLEGLRYVSPIYALGEKEQIVHLLASSVSELFSFIMGALLIVASLSPPQQEPFGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB4</accession>
    <name>A1RXB4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752109.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77844">
        <property type="protein sequence ID" value="ABL77844"/>
        <property type="gene ID" value="Tpen_0435"/>
    </dbReference>
    <dbReference type="GeneID" id="4602170"/>
    <dbReference type="KEGG" id="tpe:Tpen_0435"/>
    <dbReference type="eggNOG" id="arCOG03936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167329_0_0_2"/>
    <dbReference type="OMA" id="NITFRFN"/>
    <dbReference type="OrthoDB" id="123301at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="105" mass="11560" checksum="EC09F59301529C79" modified="2007-02-06" version="1">MSSGGRRGARGLNITSLPYKVKVYSNNQVLVPAQLVRSLGIQDIEYAEITIRHASSTVSFVARLLKTRFTDSRQFTIPKEVREKIGVAPGMEIEVVEIKPASSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD4</accession>
    <name>A1RXD4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752129.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0455"/>
    <dbReference type="EnsemblBacteria" id="ABL77864">
        <property type="protein sequence ID" value="ABL77864"/>
        <property type="gene ID" value="Tpen_0455"/>
    </dbReference>
    <dbReference type="GeneID" id="4601858"/>
    <dbReference type="KEGG" id="tpe:Tpen_0455"/>
    <dbReference type="eggNOG" id="arCOG04051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174522_1_0_2"/>
    <dbReference type="OrthoDB" id="128953at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="89" mass="9938" checksum="E00EC72BAF9A6A37" modified="2007-02-06" version="1">MLAICDEKLLGVELEYNNVRVKITRDFFGGSLVLLDDELLRKEIAGADSITAFGEDSLSLLEEIYPSVRKASLRVAGVPYVQVFRIMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE0</accession>
    <name>A1RXE0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="2">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truB</name>
        <name evidence="5" type="ordered locus">Tpen_0461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752135.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0461"/>
    <dbReference type="EnsemblBacteria" id="ABL77870">
        <property type="protein sequence ID" value="ABL77870"/>
        <property type="gene ID" value="Tpen_0461"/>
    </dbReference>
    <dbReference type="GeneID" id="4600988"/>
    <dbReference type="KEGG" id="tpe:Tpen_0461"/>
    <dbReference type="eggNOG" id="arCOG00987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_0_2"/>
    <dbReference type="OMA" id="GPFKEDE"/>
    <dbReference type="OrthoDB" id="36028at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DKCLD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="3">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="338" mass="38213" checksum="86BCD44F19DCE9F8" modified="2007-02-06" version="1">MPAKYLAATPSREIYVRSEDETDFSYGWLPEERPPEVLLKYSVINLDKPVGPSSHEVVAWLRKLLGIERIAHAGTLDPKVSGVLPITLNNAVRVLPVLLKEDKEYVCVMRLHGDVDPERLERVVSMFKGRIYQRPPLRSAVKREVRIRQIYDIRLLEFNERTALLHVWCEAGTYMRKLCHDIGEILGVGAHMQELRRIRSGSLYEDRNCSTMHDVVDAYYIWKERGIDHFLRQVFLPVEAAIQHLPKVWIRDSAVDAVCHGAPLAVPGIVKLEGGIKVNSTVAILTLKGELVAIGKAQMTTEKMLTESSGIAVKTEHVVMDPGTYPRKWKSHKEASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF1</accession>
    <name>A1RXF1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl39e</name>
        <name evidence="5" type="ordered locus">Tpen_0472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752146.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0472"/>
    <dbReference type="EnsemblBacteria" id="ABL77881">
        <property type="protein sequence ID" value="ABL77881"/>
        <property type="gene ID" value="Tpen_0472"/>
    </dbReference>
    <dbReference type="GeneID" id="4602031"/>
    <dbReference type="KEGG" id="tpe:Tpen_0472"/>
    <dbReference type="eggNOG" id="arCOG04177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_4_0_2"/>
    <dbReference type="OMA" id="KMRYWRR"/>
    <dbReference type="OrthoDB" id="131584at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="50" mass="5966" checksum="E1B63C3354956DF6" modified="2007-02-06" version="1">MAHFKPLGKKLRLAAAVRSNEQVPIWVISKTLGKVRRKPRRNWRRSRMQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG2</accession>
    <name>RL14_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl14</name>
        <name type="ordered locus">Tpen_0483</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752157.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXG2"/>
    <dbReference type="SMR" id="A1RXG2"/>
    <dbReference type="STRING" id="368408.Tpen_0483"/>
    <dbReference type="EnsemblBacteria" id="ABL77892">
        <property type="protein sequence ID" value="ABL77892"/>
        <property type="gene ID" value="Tpen_0483"/>
    </dbReference>
    <dbReference type="GeneID" id="4601878"/>
    <dbReference type="KEGG" id="tpe:Tpen_0483"/>
    <dbReference type="eggNOG" id="arCOG04095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="91632at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019971">
        <property type="entry name" value="Ribosomal_L14P_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03673">
        <property type="entry name" value="uL14_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000355853" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="141" mass="15380" checksum="8F4B95F2486C25F9" modified="2007-02-06" version="1">MAKRGPKTVGVSYRLGLTPGVFMESLVKVADNSGATLAKVIGVPHYKAVWRRIPGAAVGDIVIVSIRAGKPELRKQVMRAIVIRQRRPYRRPDGSWIAFEDNAVVIITPEGEPKGTEIRGPLAKEAAERWPKLSAMASIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG3</accession>
    <name>A1RXG3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps17</name>
        <name evidence="3" type="ordered locus">Tpen_0484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752158.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0484"/>
    <dbReference type="EnsemblBacteria" id="ABL77893">
        <property type="protein sequence ID" value="ABL77893"/>
        <property type="gene ID" value="Tpen_0484"/>
    </dbReference>
    <dbReference type="GeneID" id="4601782"/>
    <dbReference type="KEGG" id="tpe:Tpen_0484"/>
    <dbReference type="eggNOG" id="arCOG04096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="OMA" id="DPECPWH"/>
    <dbReference type="OrthoDB" id="108145at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12495" checksum="AA379C886197D051" modified="2007-02-06" version="1">MAKLKGVGIPGVSPPQMKCNDPLCPWHGELPVRGQVLRLRVEKVKMHNVAVAVHEYLYYNEKYKRYEVRRKKKHVRVPPCIPVKPGDEVIVAETRPLAKSVSFVVIGKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI2</accession>
    <name>A1RXI2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0505"/>
    <dbReference type="EnsemblBacteria" id="ABL77912">
        <property type="protein sequence ID" value="ABL77912"/>
        <property type="gene ID" value="Tpen_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0505"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OMA" id="TIRDSWI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="13938" checksum="8BF8C2868036F810" modified="2007-02-06" version="1">MDAFHARDEMFINRHVEESIQTRETMSAELLDNILKGVFKEQQLIKIRVEKRKGHRDVTIITGLDVKDPELRRMVSEMKAKFACGGTIKDDHVELQGDHRYKVKEFLVLNGFPESNIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL9</accession>
    <name>A1RXL9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752214.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0543"/>
    <dbReference type="EnsemblBacteria" id="ABL77949">
        <property type="protein sequence ID" value="ABL77949"/>
        <property type="gene ID" value="Tpen_0543"/>
    </dbReference>
    <dbReference type="GeneID" id="4600500"/>
    <dbReference type="KEGG" id="tpe:Tpen_0543"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="PCILEIG"/>
    <dbReference type="OrthoDB" id="29720at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="300" mass="32736" checksum="763464D012872E2A" modified="2007-02-06" version="1">MSHKAFPREEYILKGHAACPGCGATLLLRHVLKALGPNTYLVIPACCTSVIAGPHPRSAFKVPVLHIAFAASAAAASGMVEALEKLGKPANVVVWAGDGGTVDIGLQALSGAAERGHNLIYICYDNEAYMNTGIQKSGSTPYKAWTTTTPTGNLSVKKDVPSIMVAHRVPYVATINPAYVNDLYYKLRKAAQIKGGLKYIHAFSPCPVGWRYDSSLTVKVARLAVETGVWVLYEVENGMFSLTGPSKALVDKSKRKPVAEYLRLQGRFSHLKEEDIAEIQRLVDEQWERIAEILREQEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP1</accession>
    <name>A1RXP1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752236.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77971">
        <property type="protein sequence ID" value="ABL77971"/>
        <property type="gene ID" value="Tpen_0565"/>
    </dbReference>
    <dbReference type="GeneID" id="4600608"/>
    <dbReference type="KEGG" id="tpe:Tpen_0565"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="OrthoDB" id="26292at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="471" mass="54430" checksum="B4D88F13BF1F6A18" modified="2007-02-06" version="1">MVERYMRGNGAGEGFEEFDEWFIRRKIEELLRRALFPPSGYRGLKATHEEVAQELAEIRGNYAQYGEAYVEYVGRLGEGEEKAFREAEKAMREALKRVDELKIKRTGKTRWKAKLPGEKWRIYVSRKPNGYWSVEVVLLLKIARLRLPDVLELSPELLVAAQTGWILGDASYIADHGRVDMATAQSWQVASFPGFWPGKEVTVYVRSIVINETRVSMVWFIYVHGVRDAPREWALRKEEKQGIILAEIEAANEGKVDIVRALKLALLYVTDGEYPGSSNTGKHLLQFAVGQRSRQVRTEGAVRVARLLYEKVPQLLEYMAASGCQKAEFLASLASVKPRHYAPRYLEVCGVKMNLRLAGPKNRRYLMAQVYITRNNEEMLRDFPERARREGLEVRRVKVSKRYWGYRAGEKSLMKYADRYPRVYDTLIAFVQEELEAMPLDHPARPSVERLLERLRKARERALKKLGARQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP8</accession>
    <name>A1RXP8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752243.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0573"/>
    <dbReference type="EnsemblBacteria" id="ABL77978">
        <property type="protein sequence ID" value="ABL77978"/>
        <property type="gene ID" value="Tpen_0573"/>
    </dbReference>
    <dbReference type="GeneID" id="4600617"/>
    <dbReference type="KEGG" id="tpe:Tpen_0573"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="WNDQQDS"/>
    <dbReference type="OrthoDB" id="29908at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="262"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="394" mass="43373" checksum="090BD9F84EB6031F" modified="2007-02-06" version="1">MKGKLVGMNGDRAVAYAAKQAKVDVISAYPITPQTIIVETLAEYVNNGELDAAFIPVESEHTALSAAVGASLAGARVFTATSSQGLALMYEILWIAAGLRAPIVMAIGNRALSPNINIHCSHDDAYAARDTGWLQFFAENVQEAYDLTLMAFRVAEDERVLLPTIVNLDGFILTHALEGLYVLEDAEVDAFLPKRKPINPIDPKNPKTYGPLDFTDWYMEHKRLQFEVYQKVGGVVREVFDEYEKLTGRHYQPVKTFNVEGADKAIVILGSSAGTARFAARKLAEKGMKLGVVSLTQYRPFPVAELRKVLESFDVVAVLDRSVSFGSPGNQLFMDVSTALYSSKKRPILVNVVYGLGGRDFTPLHVERIYAALEEVQRKGEAPEESLWVGLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT1</accession>
    <name>A1RXT1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranyltranstransferase</fullName>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0606"/>
    <dbReference type="EnsemblBacteria" id="ABL78011">
        <property type="protein sequence ID" value="ABL78011"/>
        <property type="gene ID" value="Tpen_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0606"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OMA" id="NIVAVMS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="337" mass="38076" checksum="EE023E9AC4657FE6" modified="2007-02-06" version="1">MSARVLERLGEIGALVDPVMEKYLLRGASPEFQDAVLYQVRMGGKRVRPALTIASTLAVGGKEENALPAAAAVELAHNYSLILDDIIDHSELRRGKPTVWKKYGISTAILIAVHYRESITEALNDTPEPPVFHAIMAETIKLLTDGERLDILFEQSGRSDEPYVVEQRYRAVRLDDYLRMIERKTAKLIETSCVFGALSAGQRGEILEALREYGYNLGMAFQVGDDIIDIFGEEEKTGKRVGGDIKEHKLGNVVVLLALEETRDKERLLAILRKEDVSWEEVKEAISIISETNAREKAEVLRRDYVSRALKALEKLPRSEYRDMLEELAVFIEKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV5</accession>
    <name>A1RXV5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0631"/>
    <dbReference type="EnsemblBacteria" id="ABL78035">
        <property type="protein sequence ID" value="ABL78035"/>
        <property type="gene ID" value="Tpen_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0631"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090896_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="195" mass="22285" checksum="528E33EDEEB73010" modified="2007-02-06" version="1">MALTTAFLGDDGLKYFLRLRWLYFRAGQEHIYLPTESPVFNARLAVELASEYVKFISLAMKCPKIKHFLFVGFGAPGKRSKKNGQKNNPFYAEVAGAQLHLVYISTKNHVYARIVVNDTPQGWYEKAIEEGWVVRTISMGDREYYQVTHASLMEHARYDAALRETLIAFAKAKAEQYPKAQSLVERLEKLGNQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW8</accession>
    <name>A1RXW8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0646"/>
    <dbReference type="EnsemblBacteria" id="ABL78048">
        <property type="protein sequence ID" value="ABL78048"/>
        <property type="gene ID" value="Tpen_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0646"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="708" mass="79046" checksum="5CDFE347F596DE83" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY07</accession>
    <name>A1RY07_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truD</name>
        <name evidence="6" type="ordered locus">Tpen_0685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752352.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0685"/>
    <dbReference type="EnsemblBacteria" id="ABL78087">
        <property type="protein sequence ID" value="ABL78087"/>
        <property type="gene ID" value="Tpen_0685"/>
    </dbReference>
    <dbReference type="GeneID" id="4601885"/>
    <dbReference type="KEGG" id="tpe:Tpen_0685"/>
    <dbReference type="eggNOG" id="arCOG04252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_1_2"/>
    <dbReference type="OMA" id="GFPNYFD"/>
    <dbReference type="OrthoDB" id="92795at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="175"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="444" mass="49867" checksum="9151F120A599DF86" modified="2007-02-06" version="1">MARRADSQLDRLLGLEYYGLDGAGTGGKLRSSLDDFIVREISIDGEVASPECKYAEGAGEFTWLVLEKRKIDTVSAARAVARFFGLKLRDVGIAGLKDTSAVTYQFISIPGEVKMESIEEFNLSHKRVKLHCPFRRPFALKPGMLYGNFFNVKVRGAECLECLEALLRELKEKKAVPNYYGYQRFGTVRPVTHVVGRMILLGEFKEAVEELIYKVFPGESQVSRRARLFLSESGDPLKALELFPKSLKSERAVLRHLARHPGDYVGALRAVSPYVKKLFIGAYQAYLFNKLLSKRIERGLSYYYPVPGDTVGIFREKRGGEVTGVLKVNDANVEKVKRWIDEGFAVLLLPVFGYNSNLSHGVVGEIERELLREEGIDVSMFRVKQIPEASSAGTYRYASLVPHALNVRVFGNDYELTFVLNKGAYATTLLRELVKPVEPARQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY66</accession>
    <name>A1RY66_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752411.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0744"/>
    <dbReference type="EnsemblBacteria" id="ABL78146">
        <property type="protein sequence ID" value="ABL78146"/>
        <property type="gene ID" value="Tpen_0744"/>
    </dbReference>
    <dbReference type="GeneID" id="4600395"/>
    <dbReference type="KEGG" id="tpe:Tpen_0744"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544273_0_0_2"/>
    <dbReference type="OrthoDB" id="130540at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="18929" checksum="07121298CF585C22" modified="2007-02-06" version="1">MSSLLRLLPRGFSLEVSGPPGSGRRLFVAKLVEYVVERGGSVLYVDLAGTQYRLCRSGSGLCSSERVTFTRPGDPAEAALLSFVDDDLVVLDSVPRLFFGFQAGYRERWGYVSSALLGGLRRASRGLGFVVVNYRSGEKSFGERVFASYFTHRVALEAGGKARLVYPYETPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY82</accession>
    <name>A1RY82_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752427.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0760"/>
    <dbReference type="EnsemblBacteria" id="ABL78162">
        <property type="protein sequence ID" value="ABL78162"/>
        <property type="gene ID" value="Tpen_0760"/>
    </dbReference>
    <dbReference type="GeneID" id="4601081"/>
    <dbReference type="KEGG" id="tpe:Tpen_0760"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331688_0_0_2"/>
    <dbReference type="OrthoDB" id="87728at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="628"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="874" mass="95235" checksum="F348927898670B58" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA3</accession>
    <name>A1RYA3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="14">IOR</shortName>
            <ecNumber evidence="14">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">Tpen_0781</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="14"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752448.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0781"/>
    <dbReference type="EnsemblBacteria" id="ABL78183">
        <property type="protein sequence ID" value="ABL78183"/>
        <property type="gene ID" value="Tpen_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="4601842"/>
    <dbReference type="KEGG" id="tpe:Tpen_0781"/>
    <dbReference type="eggNOG" id="arCOG01609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_2"/>
    <dbReference type="OMA" id="IGDSTFM"/>
    <dbReference type="OrthoDB" id="20764at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABL78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="623" mass="67717" checksum="5C0CEE6AFF1660B8" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA9</accession>
    <name>A1RYA9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78189">
        <property type="protein sequence ID" value="ABL78189"/>
        <property type="gene ID" value="Tpen_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0787"/>
    <dbReference type="eggNOG" id="arCOG14971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091426_0_0_2"/>
    <dbReference type="OrthoDB" id="121540at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="121" mass="13685" checksum="9E91889748F182C2" modified="2007-02-06" version="1">MTDFKEVGRVGYMGEKTKPSKLLIVVTMIPVLLDGAVWMVTEGFNVKPRFFPPLVYAVGSLVMLVLAVFVSFIGYTMSKDEEPEWGSKLPFKLIQALNILWVLVSVMFALLVVFIYFMRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC4</accession>
    <name>A1RYC4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78204">
        <property type="protein sequence ID" value="ABL78204"/>
        <property type="gene ID" value="Tpen_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0802"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="57" mass="6385" checksum="7C10FA4EA157C3F8" modified="2007-02-06" version="1">MLVNAGARLYEARLAEALDAIEEFLASVRGIPQVEEDEELARELEEDVEELRELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF7</accession>
    <name>A1RYF7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752502.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0836"/>
    <dbReference type="EnsemblBacteria" id="ABL78237">
        <property type="protein sequence ID" value="ABL78237"/>
        <property type="gene ID" value="Tpen_0836"/>
    </dbReference>
    <dbReference type="GeneID" id="4601545"/>
    <dbReference type="KEGG" id="tpe:Tpen_0836"/>
    <dbReference type="eggNOG" id="arCOG01679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_9_1_2"/>
    <dbReference type="OMA" id="WYVYELA"/>
    <dbReference type="OrthoDB" id="121334at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="11670" checksum="F076919BFF88C5FF" modified="2007-02-06" version="1">MGDTAGIEELSEVLQVLANPIRLKMLSLIAVRPRYAYELSKMLNLSYPLTYLHLSILEKAGLVESYYVEGPRTKRIYRLRDFEVKISPEVLRKMGEKLENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG2</accession>
    <name>A1RYG2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase</fullName>
            <ecNumber evidence="4">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0841"/>
    <dbReference type="EnsemblBacteria" id="ABL78242">
        <property type="protein sequence ID" value="ABL78242"/>
        <property type="gene ID" value="Tpen_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0841"/>
    <dbReference type="eggNOG" id="arCOG04779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_2"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="33514" checksum="8C77A82AAD805068" modified="2007-02-06" version="1">MKSDVCANIIPTVAVHGGAGRARKIEPEEKREIENALIEALKRGLEALRGGTSLDAVEEAVKSMEASGVFNAGKGAALNLKGEVELDAGIMWGKDLSVGAVASLRRTWNAVSLARVVMEKTDHVLLVGPGADALAERLGFEPHPGPSPRALRRYEEYRRLLASKEYYLWSRNYSVAEVFLGDTVGAVAIDSEGNLAAATSTGGLFLKLPGRVGDSPIPGAGVYAENGVVAVSATGIGEVILRSTLAARIASLVRSGARVEDALREVVSSVTSKFGENTVGVIAIDGSGSYAEYTNCEVFVRGWASVSKGMPRASLEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG6</accession>
    <name>A1RYG6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0845"/>
    <dbReference type="EnsemblBacteria" id="ABL78246">
        <property type="protein sequence ID" value="ABL78246"/>
        <property type="gene ID" value="Tpen_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0845"/>
    <dbReference type="HOGENOM" id="CLU_1718314_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="17015" checksum="55FD99071256645D" modified="2007-02-06" version="1">MSYAKLLALLGILMSVLSIALASYLLLTLEKTSRILDNALKYLGAVEKSYSVDAYSPVNVRVCLAVNSSTELSRMTCTNGTYLSGSTLLAVISKHYEVAVRSDGVRVWVESVRGEPCNGSWKVYATNGSSLSERYDLLLPVGGSSEVLVVCEAQKTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG9</accession>
    <name>A1RYG9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752514.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0848"/>
    <dbReference type="EnsemblBacteria" id="ABL78249">
        <property type="protein sequence ID" value="ABL78249"/>
        <property type="gene ID" value="Tpen_0848"/>
    </dbReference>
    <dbReference type="GeneID" id="4601973"/>
    <dbReference type="KEGG" id="tpe:Tpen_0848"/>
    <dbReference type="eggNOG" id="arCOG00407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_2"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="24864at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="130"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="430" mass="48543" checksum="5039A767A123A2DA" modified="2007-02-06" version="1">MSTAVKPIREALRLPAGSQVTVRGWVYRRRDLGDKAFVVVRDSTGIIQAVFTPESPGHALARKVTVESSVIVGGALREDPRAPGGKEIAGRNIEIVGLAENFPIRRDASREFLLEVRHLAVRSRKMTAVLKLRSTVFEALHEWFRSNGFYEVHCPMFISAAVEGGATLFPVKYVDGSTVYLTQSSQFYLEALIYSLEKVYTVAPSFRAEKSRTRRHLTEFWHAEAEVAWTGLEGILKVEEELVSHIVRRVLEKNREELELLGRNLEPLKNVEPPFPRISYDKAIEILQGKGLNVKWGDDLGADEERALTEEFDKPFFLYGFPVGVKAFYHKNDPSRPEVTLSADLLAPEGYGEIIGGGERIEKLEELLDKIKQFGLNPSDYEWYLDLRRYGTVPHAGFGLGMDRLVTWIAGLDHIVDSIPFPRTVTRTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI6</accession>
    <name>A1RYI6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolases of the beta-lactamase superfamily II-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0865"/>
    <dbReference type="EnsemblBacteria" id="ABL78266">
        <property type="protein sequence ID" value="ABL78266"/>
        <property type="gene ID" value="Tpen_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0865"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192676_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="235" mass="25692" checksum="794CC84836A0536C" modified="2007-02-06" version="1">MTGTGEAPVSLTLKVLVDDVPSVEGVVPAHGLSILVEARYRGYEKRLLFDAGPSGRILLYNAKIMGVDLKPDFAVGSLPLYHHVGGFKILDRRIPVIKPRRVLPEPREASISELPHLPGFYLVMSPSHWNEQALMVSLELGAVLITGCSVHGFYETFGWILKGSLKLYGLVGGLGISTRDFVNMRFLRRLARGGLSLVFPLHSTSLEARRSIVKTLNKHPLEYDVPGAGAEVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ5</accession>
    <name>A1RYJ5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0874"/>
    <dbReference type="EnsemblBacteria" id="ABL78275">
        <property type="protein sequence ID" value="ABL78275"/>
        <property type="gene ID" value="Tpen_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0874"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="72" mass="7836" checksum="AC5D3EA6794E5EA9" modified="2007-02-06" version="1">MVDGAPLRGARSRLLASTLKGDGLYEARLVKALDAIEEFLASVRGAPRVEEDEELAREIEENVEELRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL8</accession>
    <name>A1RYL8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752563.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0897"/>
    <dbReference type="EnsemblBacteria" id="ABL78298">
        <property type="protein sequence ID" value="ABL78298"/>
        <property type="gene ID" value="Tpen_0897"/>
    </dbReference>
    <dbReference type="GeneID" id="4600474"/>
    <dbReference type="KEGG" id="tpe:Tpen_0897"/>
    <dbReference type="HOGENOM" id="CLU_856914_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="324" mass="36869" checksum="0C5F53ABE1A7CB93" modified="2007-02-06" version="1">MSLEAVVETPKKKRDILFYLSKASTTTAQNMEKVEELYRAVQSRGSSNPLLGRLVEKTLKLLKVPEPPGISEAERLAESLESYGASLQRVAAALEDLLRVVDSAESLLRRLEDVKQALESWAEVFQGLNASLYGEIAREISRIERLPQEDYQDVKEFHDKLEDLLDEAERLSARARSEYNKLVELALRELEATREVLQRAESVAALHEKARLEALGSALQRVEQELRSLRQSPRSFDVNGVYRELGRVKSEAQQVLRTALSEQEVKVFDETARFFYIVGQKPVHLTELVEYVSRRTSYPHADVLKTLYDLSSRGVIRIKVSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM2</accession>
    <name>A1RYM2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752567.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0901"/>
    <dbReference type="EnsemblBacteria" id="ABL78302">
        <property type="protein sequence ID" value="ABL78302"/>
        <property type="gene ID" value="Tpen_0901"/>
    </dbReference>
    <dbReference type="GeneID" id="4602224"/>
    <dbReference type="KEGG" id="tpe:Tpen_0901"/>
    <dbReference type="eggNOG" id="arCOG04280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_2"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="61440at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="34019" checksum="BDD375403CBC202F" modified="2007-02-06" version="1">MKYAVAVDIGATQTRVALGNDEGEILELHVFKTSSFPGPDEYLRHIAGLALSLEKKHGVEVEGIGVGSPGPLDMKKGEVLKSVNMPFDRLPVVSALKSLTGKKVAFANDAVTAAVGEKYWGAGRGLENLVYVTISTGIGAGIYVDGELLLGKHGNAHEVGHVVVDSGEEMTCGCGKKGHWEAYCSGSGIPRYAKFLAARNPELWEKSPLKSREPLTAKDVFDAFREGDALARLVMERVRKFNAYGFAVLVNVYDPEIITVGGSVALNNPDVLLAGLKEEVEKYALNVVPEIRLTPLGDKIGVLGALALGLGLEKKVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM5</accession>
    <name>A1RYM5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752570.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0904"/>
    <dbReference type="EnsemblBacteria" id="ABL78305">
        <property type="protein sequence ID" value="ABL78305"/>
        <property type="gene ID" value="Tpen_0904"/>
    </dbReference>
    <dbReference type="GeneID" id="4602227"/>
    <dbReference type="KEGG" id="tpe:Tpen_0904"/>
    <dbReference type="eggNOG" id="arCOG00923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="FQAYHLF"/>
    <dbReference type="OrthoDB" id="71950at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="249" mass="27516" checksum="8CD35AB6A1619F6C" modified="2007-02-06" version="1">MRDEILVLEDIEAGYEGTPVIRGVSLSVRRGEKVVVMGPSGSGKSTLLKVAVLLVKPWKGRVWLDGEELTSGRVDLRKARAKTGFVFQSYNLFPHMKVIDNVALPLRIVKGYDKARAREKAASLLRQVGLAGFEEKYPLQLSGGQQQRVAIARALAMDPVILFLDEPTSALDPELKGEVLDVLLEVAKQGIAMLAVTHELDFAREAADRIVIMEHGRIIEEGPAQQILDSPSTPRVKEFLRLVRRTEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN9</accession>
    <name>A1RYN9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752584.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0918"/>
    <dbReference type="EnsemblBacteria" id="ABL78319">
        <property type="protein sequence ID" value="ABL78319"/>
        <property type="gene ID" value="Tpen_0918"/>
    </dbReference>
    <dbReference type="GeneID" id="4600814"/>
    <dbReference type="KEGG" id="tpe:Tpen_0918"/>
    <dbReference type="eggNOG" id="arCOG10502">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514694_0_0_2"/>
    <dbReference type="OrthoDB" id="96856at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="166" mass="18165" checksum="8BE08E22055EFE82" modified="2007-02-06" version="1">MARRRGQVRIIEAVLATFMVVAIILLVMSFARPLRSVYVRETSDLRRLAYNLLNNMADNGVFEKTLANLNPSAAQGGGCTLYDLAMMATASLPPGILFRMDVYRVDFDVSAGNTSLVWLGCASNYDTNTTRLVESEPVSYTYVCTGDPDSVRGTALYILLTIGYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP7</accession>
    <name>A1RYP7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752592.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0926"/>
    <dbReference type="EnsemblBacteria" id="ABL78327">
        <property type="protein sequence ID" value="ABL78327"/>
        <property type="gene ID" value="Tpen_0926"/>
    </dbReference>
    <dbReference type="GeneID" id="4600749"/>
    <dbReference type="KEGG" id="tpe:Tpen_0926"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_1_2"/>
    <dbReference type="OMA" id="GNHDTML"/>
    <dbReference type="OrthoDB" id="105276at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00024">
        <property type="entry name" value="SbcD_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="260" mass="29195" checksum="0140687137DCBE2F" modified="2007-02-06" version="1">MARTSVLEVPRLRLRRGLEVVGYGLYVEELGSLLVADLHVGYEGALAEQGVFVPPLQAREMKEALAAMIGESGAERVIILGDVKHEFGDVTRQEWRETIDLLEYLKRGLGVRVDVVRGNHDNYLVVVLKRLEIPFHDPYLLEGDWLFIHGHKPFPVEGFREDVRFVAMGHEHPALALRDSLGVKVKLKALLEGSYTGKQVYVLPALSPLMPGTEVNVERSFLSPLLRETGVDEYKAYGVDLEAGIFDFGEVKYLRNVSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR5</accession>
    <name>A1RYR5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid-binding protein, PBP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752610.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0945"/>
    <dbReference type="EnsemblBacteria" id="ABL78345">
        <property type="protein sequence ID" value="ABL78345"/>
        <property type="gene ID" value="Tpen_0945"/>
    </dbReference>
    <dbReference type="GeneID" id="4601074"/>
    <dbReference type="KEGG" id="tpe:Tpen_0945"/>
    <dbReference type="eggNOG" id="arCOG04702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_3_0_2"/>
    <dbReference type="OMA" id="CWVVVNI"/>
    <dbReference type="OrthoDB" id="98388at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="192" mass="20318" checksum="1200196AEA48E999" modified="2007-02-06" version="1">MNKRYVLLAALLLAVLLAVAYVALRPRRPSIDELLGAAKKGARVELRVAGLTAGRMPREYTCDGADESPDVSWGELPPGTRSLVLLCVDPDAPRGTFVHWVLYNVPASATRVPRSLPKAPTTPFGLQGVNDFGFTGYGGPCPPSGTHRYVFVLLALDSELALSGGADALTVLSKASGHVIGYGEVVLTYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR9</accession>
    <name>A1RYR9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752614.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0949"/>
    <dbReference type="EnsemblBacteria" id="ABL78349">
        <property type="protein sequence ID" value="ABL78349"/>
        <property type="gene ID" value="Tpen_0949"/>
    </dbReference>
    <dbReference type="GeneID" id="4601289"/>
    <dbReference type="KEGG" id="tpe:Tpen_0949"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="24071at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="412" mass="44792" checksum="37E02C34DA8F0BDF" modified="2007-02-06" version="1">MLDPYRVRRDFPILSKKVHGKQLVYFDNAATSQRPLQVVEAVESFYKSLNANIGRSVHELGLRATEAYEDSRKIVAAFIGAKPEELVFTKNTTESINLAAYSLLVSGLISRGDAIVVTRMEHHSNLLPWVRVAKLAGAELRVVDVDDEGRLRLDEYEKALSRGAKIVAVTHVSNVTGVVNPVKELCRLAHDAGAFCLVDGAQSTPHMRVDVKDIGADFFAFSGHKMLGPMGTGGLYIRGDLAERLEPPFPGGGAISLVSCAEDSCSAEWLHPPHKFEAGTPNVAGAVGLAKAVEYLRSVGMEDVEEHEKRLTAKLLEVLEGVGARIYGPRDMKDRLGVVSFNLDGLTPHEVASMLDLEGIAVRSGHHCALPLVKRLGSPMGTVRASLYLYNTPEEVEYFGAVLEKIKKLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS5</accession>
    <name>A1RYS5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752620.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0955"/>
    <dbReference type="EnsemblBacteria" id="ABL78355">
        <property type="protein sequence ID" value="ABL78355"/>
        <property type="gene ID" value="Tpen_0955"/>
    </dbReference>
    <dbReference type="GeneID" id="4601295"/>
    <dbReference type="KEGG" id="tpe:Tpen_0955"/>
    <dbReference type="eggNOG" id="arCOG04267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168718_0_0_2"/>
    <dbReference type="OMA" id="KPIIILY"/>
    <dbReference type="OrthoDB" id="115397at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="13021" checksum="3A007C95FAFC6CE0" modified="2007-02-06" version="1">MTTARAIYRGRLLEKRYGVLGKVARRYLEAGLSVELLHPTRHGPIHVIARGNKQVLAIEVADKPGKVGADRVKLLLEKAKLVKAKPVLVLYSEGAFLDEEARKLCEENKVKVKVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV0</accession>
    <name>A1RYV0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0980"/>
    <dbReference type="EnsemblBacteria" id="ABL78380">
        <property type="protein sequence ID" value="ABL78380"/>
        <property type="gene ID" value="Tpen_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0980"/>
    <dbReference type="eggNOG" id="arCOG05472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313184_0_0_2"/>
    <dbReference type="OMA" id="HAVEVNI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="209" mass="23446" checksum="AA599F0FBDFF3BC4" modified="2007-02-06" version="1">MRRVGVDVVRLMVSVARALRRADLPYAVVGGLACILMGVRRVTEDVDVVVLVRAREDVEKLVRELRSEGIELPSSDALKALQNRGLVAALVGPLRVDIRYASTWLDFETIRHAVEVNIRGEPVRIASLEDVVAAKLTVLRTLRDVEDAVQLMVQYRDRIDWERLRRIVGGSPLEVVKQLLDAIEGELGGDEVVRRRINDVRSLLTKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY6</accession>
    <name>A1RYY6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SSU ribosomal protein S25E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752681.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1016"/>
    <dbReference type="EnsemblBacteria" id="ABL78416">
        <property type="protein sequence ID" value="ABL78416"/>
        <property type="gene ID" value="Tpen_1016"/>
    </dbReference>
    <dbReference type="GeneID" id="4600689"/>
    <dbReference type="KEGG" id="tpe:Tpen_1016"/>
    <dbReference type="eggNOG" id="arCOG04327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171557_0_0_2"/>
    <dbReference type="OMA" id="SKGHRTE"/>
    <dbReference type="OrthoDB" id="122611at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_S25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="12578" checksum="1B6C9F81561665A8" modified="2007-02-06" version="1">MGGGKKRPTVSQLEKRVTKEEKKKEEGGKKPQMKLEASTGNLTEVSLEHVIKEIRGLKYVTPYVLASKFSLKLSRAKKVLRELESRGVVVAYDKNSRVPIYVPVAKSHKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ9</accession>
    <name>A1RYZ9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIR synthase related protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1029"/>
    <dbReference type="EnsemblBacteria" id="ABL78429">
        <property type="protein sequence ID" value="ABL78429"/>
        <property type="gene ID" value="Tpen_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1029"/>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591373_0_0_2"/>
    <dbReference type="OrthoDB" id="74509at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="465" mass="49179" checksum="A9DA3CEC19CD8024" modified="2007-02-06" version="1">MVTPLENRLGKIPLAALRELLLGAGAGLELDANPLTGDLLVTTNPAIGVPEEWLGFFAYHYSASNLAVSFARPELAVLSAVFPEGYPGEAVERVLRSFVEECRKYGTRLVGGHTARYRGLELPLLSSTMVGRAGRRREKPAGGDRVVIVGEVGAEAAWLAGGDVDPSTLTPLPAALALQEEPSIKLMHDVSEGGVIGALLEVAQRYGVALEVSSRDVKVFEGLPRGVEPLSAPSYGAIIAVTGDAESLLSACEEKGLTCSNAGVVAGPGNPLVVVDGREYAEPPVSPLVYLYGAERRSPEEAAVALAAEELVRISRLLDVIPEVGANIAYAPGPVRSPRDVLALDGRIVKTTEGARLCGKPRYGASRHLAEVLASAREAGMPYSAAVNLKYSEDLLEKLKSIGLPVCDATPYEASCPVSEAIRSGCRAQVYFYAGKPGLEASIVLLARDPLEAIEILRKVVEQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ01</accession>
    <name>A1RZ01_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752696.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1031"/>
    <dbReference type="EnsemblBacteria" id="ABL78431">
        <property type="protein sequence ID" value="ABL78431"/>
        <property type="gene ID" value="Tpen_1031"/>
    </dbReference>
    <dbReference type="GeneID" id="4600510"/>
    <dbReference type="KEGG" id="tpe:Tpen_1031"/>
    <dbReference type="eggNOG" id="arCOG01773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_14_0_2"/>
    <dbReference type="OMA" id="CIVPRES"/>
    <dbReference type="OrthoDB" id="118313at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="222" mass="24511" checksum="7DEC312E116EDD22" modified="2007-02-06" version="1">MRGRGILELFSEVAGQYDSWYDSPAGRVVLEVEASMLDEVLPSGIGVDVGAGTCRFAPFLSRGREIVCLEPAYGMLVYGYARGRCEHPLCATSENAPLRPSFDFAYMVTVLEFLEDPALSLTRIWEALKSGGLLAVLYVERDSKWGKLYSELAEKGADPVLARARFYSQPEVDKLLSAAGFEVREHLKSLDYEPLTVPAEKPRVYRESCADCGVTLTVAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ06</accession>
    <name>A1RZ06_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1036"/>
    <dbReference type="EnsemblBacteria" id="ABL78436">
        <property type="protein sequence ID" value="ABL78436"/>
        <property type="gene ID" value="Tpen_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1036"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066799_0_0_2"/>
    <dbReference type="OMA" id="VGYGWVF"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="32277" checksum="6C59011B3B84F730" modified="2007-02-06" version="1">MKPCGWGVPYSVDDVLRIPGDAVLETVRGYRIFVDGRLLHEYSGRRLGDIVDKEAFIRYLLEGVDVVHVGVSPGRLSEYSLVVDARGHAAYPGRKALALQATVRVEPPREEIWVYFYSDLVGYGWVFPAGDRAAHVGVGGLAGKEFLERRLAELLRTVRGEVVRVSGSPIASGGLKPGKGRLAVGEALGAVMPLTGEGIRPGLISARAVYESIAKGKPLEEHLKTSGLALNVELQLRILSLLEKSTPEERVRVFSSAPLELLERVTAGNVEPRELLGFSLRYPAFFARLGLKAVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ57</accession>
    <name>A1RZ57_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1088"/>
    <dbReference type="EnsemblBacteria" id="ABL78487">
        <property type="protein sequence ID" value="ABL78487"/>
        <property type="gene ID" value="Tpen_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1088"/>
    <dbReference type="eggNOG" id="arCOG01540">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_2_2"/>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="119"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="456" mass="46928" checksum="0746997D83F8D3BE" modified="2007-02-06" version="1">MNPAQTVTAATGLLAAVAALSPYFKGKTRQLLALTLLDVALAALAELHVIFSGGLSQGELLADRYAALLALVFLLDLSIVLLGSSSTVAQYEEGNALIGAVALAAAGLLGISVSGTVPLLLVSWVLVSAASYASIALPRDKYSASGASKYGLMSLASSMLLLTALGLASFNSPSLSLPSVVPAGREVAALALAFTVASVGFKAGAFPFHAWLPDTYGVSDPYPVSIVAPLSKGAVLLAFYKVSAILAPEARQEWLWIVGLIALLTMTYGNITALLQRGFQGLLAYSSIAHAGYLLVGVAALSSQQAAPTALYGLVLQLAAYSFAKTGLFLLARLARAREGPPVALDDLRGLSTVDKPLAASATILVLSLMGMPPLAGFWGKLFIFLAAVGPAPWLTAVALINTGIAAAYYARIIKAVYFEPGKPHLYADRGLKVVIVVTAAASLLAGLVPLVLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ58</accession>
    <name>A1RZ58_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752753.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1089"/>
    <dbReference type="EnsemblBacteria" id="ABL78488">
        <property type="protein sequence ID" value="ABL78488"/>
        <property type="gene ID" value="Tpen_1089"/>
    </dbReference>
    <dbReference type="GeneID" id="4602129"/>
    <dbReference type="KEGG" id="tpe:Tpen_1089"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_2"/>
    <dbReference type="OMA" id="TFYTHPE"/>
    <dbReference type="OrthoDB" id="47310at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="100"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="425" mass="47123" checksum="AD3ACB36A7971682" modified="2007-02-06" version="1">MQGEDFERAFKQLRDKGVKFFEVVFQDLGGVLRGRVLKPEKPDDVARGFRIDAFSTGFSGVEDSDATLLPDLSTLRVYESSIGRTGFLIGDLYRGGKPMETYPRNLLKKWEAESRYKVLLGAELEFYLARDYKPVDNGGYMYVSPYSTVYPVIAEIVTKAEEAGLALKAAHHEVGPGQYEVLPTPMSPLALSDAIVFLKKLIWEAASARGLQATFMPKPFNGLPGNGLHVHISVHDGDRNVLFEDGELTEEGRSVIGGLLAYTVPLILFTNPTINSYKRLVPGFEAPIYLTWGRGNRSTMIRVPMGLRGASGVVEYRLPDSSGNVYLKALAVLYSAERGLRERVDPGPECRVNAFLADGYPRIPGTLGEALEKSLESIGKAPELRDLLSKVAELEKGEWRRYLEEAGSPEASEVTEWEVKRYFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ87</accession>
    <name>A1RZ87_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752782.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1119"/>
    <dbReference type="EnsemblBacteria" id="ABL78517">
        <property type="protein sequence ID" value="ABL78517"/>
        <property type="gene ID" value="Tpen_1119"/>
    </dbReference>
    <dbReference type="GeneID" id="4600861"/>
    <dbReference type="KEGG" id="tpe:Tpen_1119"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_0_2"/>
    <dbReference type="OrthoDB" id="110591at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="275" mass="29495" checksum="60F6074710388262" modified="2007-02-06" version="1">MRERVALLTFLAVLGITVAKLAVYALTSSMAAFTEFVDSVTDIATSALALLSVRLSRKPPDEDHHYGHGKAEALAGYTIGLFAGTSLAYVVAELVKRVLEGYIVRSDPLAVQIAAAIVAVDSGLAGVNYLGYRASKSVALRANAVNYMGDSLRALGVLTAITTAWLDPFVTAVLASILAVEVFHLLRESTSILMDEASEELTRRIAESLRGVEEVEEVRKIRVRHSGTHYQVDVVVAVKGGKTIEEAHRAADEVEKRVKAALGAEVDVLVHVEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD9</accession>
    <name>A1RZD9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752834.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1171"/>
    <dbReference type="EnsemblBacteria" id="ABL78569">
        <property type="protein sequence ID" value="ABL78569"/>
        <property type="gene ID" value="Tpen_1171"/>
    </dbReference>
    <dbReference type="GeneID" id="4601185"/>
    <dbReference type="KEGG" id="tpe:Tpen_1171"/>
    <dbReference type="eggNOG" id="arCOG14774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137034_0_0_2"/>
    <dbReference type="OrthoDB" id="136150at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="27919" checksum="22588DE8F608A532" modified="2007-02-06" version="1">MAGFKPFSEKTAPRARLLEEVVTVASLGAVATYLGLELAAVNQLLLPALQVAAVYPFFFRHVRGGRLWVAALTVLVWAVSVSLPVIAASYNSRGWASARVINGESYVKEMFEWIATGRGAEGDISLFLIPKLREVALFAAATAASAGLLGLLMGAILLNYMNYYVGVLLAHAKPGYLLQVALLSWQVYAVLRVVGYVFLGVALSRIAVLVFSQRRLVVEDEARRLLLYALVLIALDFVLKATVANSVYQPLLKEFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF1</accession>
    <name>A1RZF1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1183"/>
    <dbReference type="EnsemblBacteria" id="ABL78581">
        <property type="protein sequence ID" value="ABL78581"/>
        <property type="gene ID" value="Tpen_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1183"/>
    <dbReference type="eggNOG" id="arCOG02109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2985878_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="57" mass="6566" checksum="A07E6C18A000A5D2" modified="2007-02-06" version="1">METAMKMAKLASLRNIIVHRYWAIDDARILNEAKGSGTKAVREFIDEVLRYVETKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG4</accession>
    <name>A1RZG4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752859.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1196"/>
    <dbReference type="EnsemblBacteria" id="ABL78594">
        <property type="protein sequence ID" value="ABL78594"/>
        <property type="gene ID" value="Tpen_1196"/>
    </dbReference>
    <dbReference type="GeneID" id="4600388"/>
    <dbReference type="KEGG" id="tpe:Tpen_1196"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OMA" id="RDRHLPH"/>
    <dbReference type="OrthoDB" id="15038at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="455" mass="49103" checksum="D34617A0A078660B" modified="2007-02-06" version="1">MGEQRLRRRIGLLEAFSFGYADVGAGIYMTLGLVAAYAGPATPLAFAVASVSYLFTALSYAELSAAYPEAGGGMVFADRAFGRLAAFIAGWSLLLDYVVTGSIFALSTTGYLGHLFPLLKRDEFFGPVAALLVFFLVVLNILGIRESAAFSSALVLLDIAGLSVIMGIGYLTSFKPFFDKVNLGVNPDWQSFMYGSTLAMASYLGIEVISQTAEETRRAGATIPRAVKLVSVVVIFFALLFSTLAVGTVGWEVLAASQKDPAAVVAEHLPYGSVLALWVSVIGMTVCYAATNTGIVGVSRMVYAMGREGMLPRWLTELHGRFKTPYRAIVVFAVIQLLLAYVGHLGLAADLYNFGALLSYMVVNLSVLALRVKDPHRYRPYKVPGNVPLRVGGRKVYVPLGAVLGFLTNLAMWLMVVSTHKEGRLVGFAWLLAGLLVYAVYSRRRRAEPLTPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH7</accession>
    <name>A1RZH7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752872.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1209"/>
    <dbReference type="EnsemblBacteria" id="ABL78607">
        <property type="protein sequence ID" value="ABL78607"/>
        <property type="gene ID" value="Tpen_1209"/>
    </dbReference>
    <dbReference type="GeneID" id="4600411"/>
    <dbReference type="KEGG" id="tpe:Tpen_1209"/>
    <dbReference type="eggNOG" id="arCOG00263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_2"/>
    <dbReference type="OMA" id="FDVWNKR"/>
    <dbReference type="OrthoDB" id="62977at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="328" mass="34457" checksum="0C4FE88FF51F69DB" modified="2007-02-06" version="1">MATRAEGLRKAGFLAQHPEIGVVSSFFSIAAVFLVLVPDKFLTLPTFYSILTLAGELGVVSLGVAFLMITGEFNLSVSSVYALVPMGVAIMANMGVDMLLASVVMLALAYGIGVLVGYVTIKTGIPSFITSLGMMMFLRGILLAITGGFPVRLEHDHWLMYALNGPVGEQGLRTSAAWLVALTALLAFILDWTPYGNWTYAVGASPNTARELGVSVTKVKLLNFGLSSLLAGLAGLMALSRFKVVDPTLGQGLELEAITSAVLGGCLLTGGYGSITGTFLGAFLIAMTRVGLVLAKAPAYWYSAFIGVILIVATVINIFVVRKYVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI2</accession>
    <name>A1RZI2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1214"/>
    <dbReference type="EnsemblBacteria" id="ABL78612">
        <property type="protein sequence ID" value="ABL78612"/>
        <property type="gene ID" value="Tpen_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1214"/>
    <dbReference type="eggNOG" id="arCOG03871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147148_0_0_2"/>
    <dbReference type="OMA" id="YLWFAGY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="144" mass="15379" checksum="0EB2EAA2C661FD15" modified="2007-02-06" version="1">MKKRGVSPVIATLLLIVIAVAAAVLAYIWITGYQGTLTQQASTTQLQERIAIEAVSYNGTTLTAYVRNVGDVKVNITTIYVFNGSGTIINSNNNNYQLATPVVISPGQVSTVTTSVTLTAGNTYTVEVVTKYGTKASYVFTYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI5</accession>
    <name>A1RZI5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752880.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1217"/>
    <dbReference type="EnsemblBacteria" id="ABL78615">
        <property type="protein sequence ID" value="ABL78615"/>
        <property type="gene ID" value="Tpen_1217"/>
    </dbReference>
    <dbReference type="GeneID" id="4601629"/>
    <dbReference type="KEGG" id="tpe:Tpen_1217"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192595_0_0_2"/>
    <dbReference type="OMA" id="YVMFNNV"/>
    <dbReference type="OrthoDB" id="61105at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="251" mass="28560" checksum="A35FB46A7C333F3F" modified="2007-02-06" version="1">MARLLVGCCGFPVGRSKYYSMFSAVELQETFYNPPDPEKLAKLRREAPEGFVFTMKAWQAVTHPLDSPTWKRARVKPGKELADRYGFLRPTKEVFEAWELTARAAKALGARLVVLQTPPSFDASDENLRNAVEFFSSVETGDFLLGWEPRGDWLRKPERIAEVVGRFSRVVHVVDPFRSKPVVERPTAYFRLHGIGPGEVNYRYRYTDEDLSTLCSIVSGLGAEEVYVMFNNVYMAQDASRFKEKCPASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ8</accession>
    <name>A1RZJ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase domain protein, FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752893.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1230"/>
    <dbReference type="EnsemblBacteria" id="ABL78628">
        <property type="protein sequence ID" value="ABL78628"/>
        <property type="gene ID" value="Tpen_1230"/>
    </dbReference>
    <dbReference type="GeneID" id="4601162"/>
    <dbReference type="KEGG" id="tpe:Tpen_1230"/>
    <dbReference type="eggNOG" id="arCOG02017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_3_2"/>
    <dbReference type="OMA" id="HPRPAYI"/>
    <dbReference type="OrthoDB" id="76604at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="177" mass="19767" checksum="6DC77338FDB06EC8" modified="2007-02-06" version="1">MKEVERFYLVLHPRPAYIIGSGRVGEKANFMAASWVTPVAEEPPLVGVAIDVESLTHELIERYGEFTVNVVPTSMLDKLYYAGSRSGRDEDKASSIPHRKGEKVSAPVVEGAVGVVECVVHGKLRAEDVTFFAGRVVYAAVDERFFNERSGWLFKEIDLPLHNWGRGFYGVGRFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM4</accession>
    <name>A1RZM4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752919.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1256"/>
    <dbReference type="EnsemblBacteria" id="ABL78654">
        <property type="protein sequence ID" value="ABL78654"/>
        <property type="gene ID" value="Tpen_1256"/>
    </dbReference>
    <dbReference type="GeneID" id="4600422"/>
    <dbReference type="KEGG" id="tpe:Tpen_1256"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="OMA" id="FMIVVTQ"/>
    <dbReference type="OrthoDB" id="53481at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="291" mass="32396" checksum="EF0ACC3F25A78ABA" modified="2007-02-06" version="1">MPLRLIKTRELLVFLSPLLVFVAVIYYGVGWNFWLSLTSYSIYRPVLEFVGLNTYAQLFSDPDFVNALVRTLAWALLLVLGGNVLGLVIASSIFQLRSSKLRSVLTSYFIYPMAVPLVASGVIWRWLFDSVKGFNAVLAPLGFPRVEWLSGNNAFWSLVLVSLWVYSGFVALMYLAAFYNVPASAIEAALVDGADMLTVMVKIVIPASKLGLILGVVFSTLFALQMFDLPYSVLYINPFTSTLVMYLYNKFAYMVFNLSAAACIFLIALSASIAIPYSTYGLRKWILGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY2</accession>
    <name>A1RZY2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753027.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1365"/>
    <dbReference type="EnsemblBacteria" id="ABL78762">
        <property type="protein sequence ID" value="ABL78762"/>
        <property type="gene ID" value="Tpen_1365"/>
    </dbReference>
    <dbReference type="GeneID" id="4601190"/>
    <dbReference type="KEGG" id="tpe:Tpen_1365"/>
    <dbReference type="eggNOG" id="arCOG04008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840693_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="139" mass="15505" checksum="CE3A822DE9E91E9F" modified="2007-02-06" version="1">MSKKYSHLPRNLDKLITDALNAGKVLEAVDAILASQELVGKTTTTAYRRIHEVVGTVLDYLTRSTPSTARASLELARAKTIVSYQWARKQISDGIYQVVMRVLDSVASRLNNRGDLIEVAERGRAILDALAVLVYKYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S012</accession>
    <name>A1S012_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal-5'-phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1395"/>
    <dbReference type="EnsemblBacteria" id="ABL78792">
        <property type="protein sequence ID" value="ABL78792"/>
        <property type="gene ID" value="Tpen_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1395"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OMA" id="FWDSGER"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="296" mass="31466" checksum="0DC161AECAA4DEA6" modified="2007-02-06" version="1">MDLRRIGELVGKTPVLELDVPPGKVYVKLEYTNPTGSHKDRIAVYMLRSAVEEGVLRPGGSFVEASSGNTAVSLAWAGVLAGFKPIIFAEDTISKGKLGLLLGMGAEVHLVPRKPWGDPDHYVNAAKRFAEENGLPFLNQYGNEANWRAHYETTGPELLSQTGGVDAFVMGIGTGGTVIGIGKYLKERVPEARVVGVVPKGSPIAGGRLGDNIEGLASTFVPELYERHGRVVDSVEEVSLADALSSLKDLLRAGVLAGPSTGASFHVARRLASRGLRVAIIAADSVLRYPDLLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S021</accession>
    <name>A1S021_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753066.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1404"/>
    <dbReference type="EnsemblBacteria" id="ABL78801">
        <property type="protein sequence ID" value="ABL78801"/>
        <property type="gene ID" value="Tpen_1404"/>
    </dbReference>
    <dbReference type="GeneID" id="4601818"/>
    <dbReference type="KEGG" id="tpe:Tpen_1404"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="OrthoDB" id="67630at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="27000" checksum="0BB7F9587B3AA94F" modified="2007-02-06" version="1">MSSAIVLEDVWKVYGKPPNETVALRGVTLEVGRGEFFAVVGPSGSGKTTLLHLVGGLDRATRGRIVVDGVEISSLRRDAELSAYRNRTVGFVFQLFYLVPRLRVLENVELPLVKRGVPREERRRMALEALRLVGVEHLAHKYPTQLSGGEQQRVAIARAIVGKPRVLLADEPTGNLDASSSEVVMETFRRLNRELGVTIVMVTHNLELIWNCHRAAKLHAGRLAGVYTPDRYEELIASFARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S029</accession>
    <name>A1S029_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1412"/>
    <dbReference type="EnsemblBacteria" id="ABL78809">
        <property type="protein sequence ID" value="ABL78809"/>
        <property type="gene ID" value="Tpen_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1412"/>
    <dbReference type="eggNOG" id="arCOG01502">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_2_2"/>
    <dbReference type="OMA" id="ILCRLCM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="182" mass="20195" checksum="3065F7A8EA2ED908" modified="2007-02-06" version="1">MPRNRLIYFRASQPLMAGPIFILRDYLRCSGCRLCEVACSLKHEGTVWPEASRIRVFEFFPGVDVPHLCAQCRDYPCVKACRYSALRVDESTGAVLVDGEKCTGCGDCVRACPGKVMRLHPETRKAIVCDLCGGEPECVKACHEAGFDALRVVPYTSVGFKVYSTMPDQVAQRLFETLFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1S064</accession>
    <name>A1S064_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753109.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1447"/>
    <dbReference type="EnsemblBacteria" id="ABL78844">
        <property type="protein sequence ID" value="ABL78844"/>
        <property type="gene ID" value="Tpen_1447"/>
    </dbReference>
    <dbReference type="GeneID" id="4601156"/>
    <dbReference type="KEGG" id="tpe:Tpen_1447"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="REKQHDP"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="310" mass="33692" checksum="F3829BADC1515FB4" modified="2007-02-06" version="1">MLALVAEDLWKVYGSGERRVEALRGISIEVREGEVVALLGPNGSGKSTFMGIAAGVVRPTRGRLLVYGGEPYSDAGVRGRISYMPQDYGLYAELTGIENYEFYAALMEVDAKEAKRRLEELSGLLGLGEWFYKRRVSTYSGGMKRKASLALALASNPDLLLLDEPTSGLDPNARREVWGVVDGMRRSGKTVVLATHLFEDAERLADRVVVMRGGEVVAAGSQEDLKRKVGYKYAVDLELREEPGAELLERVRMLGYEAIPAGGSRVTVLGNSPNLLDEVEAIGGAGVVSASMRRVSLGDVYFLLTGVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S077</accession>
    <name>A1S077_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753122.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1460"/>
    <dbReference type="EnsemblBacteria" id="ABL78857">
        <property type="protein sequence ID" value="ABL78857"/>
        <property type="gene ID" value="Tpen_1460"/>
    </dbReference>
    <dbReference type="GeneID" id="4600586"/>
    <dbReference type="KEGG" id="tpe:Tpen_1460"/>
    <dbReference type="eggNOG" id="arCOG00723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_0_1_2"/>
    <dbReference type="OMA" id="RHNPQFN"/>
    <dbReference type="OrthoDB" id="89289at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="19063" checksum="DBB33136DAD31BB7" modified="2007-02-06" version="1">MGEVYTLGYGGLSPERFAEKVFSLGVRVVVDVRRYPRSKVEFFSGDKLSAWLAEAGVGYEWMGELGALGMARRRGELGEAPCTDSPTFRVYVAYLVSDPGALAALSRIGEMASRGLRPLLLCRERKPEHCHRQFVADALVARGFRVVHVVGDELVPHAGSPCYGYVAERLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S086</accession>
    <name>A1S086_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753131.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1469"/>
    <dbReference type="EnsemblBacteria" id="ABL78866">
        <property type="protein sequence ID" value="ABL78866"/>
        <property type="gene ID" value="Tpen_1469"/>
    </dbReference>
    <dbReference type="GeneID" id="4601587"/>
    <dbReference type="KEGG" id="tpe:Tpen_1469"/>
    <dbReference type="eggNOG" id="arCOG06053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375584_0_0_2"/>
    <dbReference type="OMA" id="VWEYTNA"/>
    <dbReference type="OrthoDB" id="94977at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="229" mass="26815" checksum="9BD721AF6BF72520" modified="2007-02-06" version="1">MARLPDEFLEWNYYGRRRLLERLLSGGAGRDMALEFTRHTPVLVTAAEVDGRIEVNGKVVGCGYVASRDYIREKIRVFREHVEESDERLSEGASMEEVEREHLERGVRLLLEHVYLERERAEKEMDFEVLATVELAKRVPWSSRHTWTLIQRNPRVSLVFFQPPSLSFEVKGYASIHLDDEYHEYVTLVHDAFHYTPPERRGDRPVYLVHVEEVYDNSASPRGFGRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S087</accession>
    <name>A1S087_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1470"/>
    <dbReference type="EnsemblBacteria" id="ABL78867">
        <property type="protein sequence ID" value="ABL78867"/>
        <property type="gene ID" value="Tpen_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1470"/>
    <dbReference type="eggNOG" id="arCOG00947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="RPMEIKP"/>
    <dbReference type="OrthoDB" id="39920at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="342" mass="37733" checksum="2FF4135E6818688C" modified="2007-02-06" version="1">MRRARLQEPLGGGVVACLACERRCRVRPGARGACGNYANVGGVLWHAGYGKLSAVELRPIEIKPLFHYWPNSLALTYSNFGCNFHCPWCQNHHLSFSLPPEGLEPVDPEALADLAVSAGAQGISASFNEPITNLDYVVDASEAARKRGLYSMMVTNMYFTTSSLRLVLEAGVDGFAASVKGCPSARRVLANVDHYVVFRNARVALDSGAHVEIVYLVVPGANDSKECYEWVVGTLLDTLGPEVPLHVNRYYPAWAWREPPTPLGKLLEVRDYAVKEGVKYVYVGNVHDPELESTRCPRCGKTLVRREGYRVVEFNLDFEGGRYKCPRCGEPVPIKGRYVAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A0</accession>
    <name>A1S0A0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753145.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1483"/>
    <dbReference type="EnsemblBacteria" id="ABL78880">
        <property type="protein sequence ID" value="ABL78880"/>
        <property type="gene ID" value="Tpen_1483"/>
    </dbReference>
    <dbReference type="GeneID" id="4601278"/>
    <dbReference type="KEGG" id="tpe:Tpen_1483"/>
    <dbReference type="eggNOG" id="arCOG05839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1207673_0_0_2"/>
    <dbReference type="OrthoDB" id="129627at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="24823" checksum="33729DEC08742588" modified="2007-02-06" version="1">MRRVLLLACALAVLAATLGVVAQSCITLEDSLAVEVVLNKPGVSLNLAALLGSGHARSVSGEVAGYRSGFDDRLVVLVGYTRISASYPFIRVQVPVAGGKPLYAVGEGEVVAVLREELERLASQGVLRGLTAGDIEAIASRARLGDAGWDLRLVYEDGEWKPFNTTKMYTPLSACPVHPELDYESLPVYPAPGPRIPVALLVAVALAVAIAIYALRLRRKRSPALDVRHRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A8</accession>
    <name>A1S0A8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BioY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753153.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1491"/>
    <dbReference type="EnsemblBacteria" id="ABL78888">
        <property type="protein sequence ID" value="ABL78888"/>
        <property type="gene ID" value="Tpen_1491"/>
    </dbReference>
    <dbReference type="GeneID" id="4601400"/>
    <dbReference type="KEGG" id="tpe:Tpen_1491"/>
    <dbReference type="eggNOG" id="arCOG02986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_3_0_2"/>
    <dbReference type="OMA" id="GPVPYTM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="220" mass="22791" checksum="8B609F81C0F01A85" modified="2007-02-06" version="1">MGTASVPAVRARYTRMGLVALAAALMCAFAQVSFKVGPVPYTMQNAGVVLAGLLLDPADAATSMLVYLLLIALGAPVAAGLRGGLAVLLGYTGGYLLGFVPSAFLMSVLSRLYLRGRGLDSANRRDLLVLLALSAVAVTPTYLLGFLVFSLYAVPGSKLYAWASGVAGWLGLGGAPGWLVLFVASVAVFVPQDLLMDHVVAVLAAREVARLLKARGIRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C4</accession>
    <name>A1S0C4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1507"/>
    <dbReference type="EnsemblBacteria" id="ABL78904">
        <property type="protein sequence ID" value="ABL78904"/>
        <property type="gene ID" value="Tpen_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1507"/>
    <dbReference type="eggNOG" id="arCOG09389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568186_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032586">
        <property type="entry name" value="UxaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16257">
        <property type="entry name" value="UxaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="480" mass="54367" checksum="C90296FA3044EB32" modified="2007-02-06" version="1">MLHVYLGKIPRPGFGIRIPEVVAPPLLSAFKSLGMTGSLMLSFNRETAPAEYIESSDPRLFYFGHTGTSIGGFIRSVKEYSKALSVPVEVEADHVSILGSVERALKKIAGVPVEEPLSEEEVSWSIGYVERELREAAEAGGVDFVTIDTCELIDYSYDKVGAEEVAAAYEEVFDGDERRALEERYEGVHYFLGGDRVVAVRLSREDVARLAVKYRRSLDYAERIYRAAREAMGVELGFEVAFDETPGVSEAREVFFYLSELLRRGLRVDFIAPNVGFRKREDYSGDLHALYERLRNLHAVVSSMNAYLSIHSGSGSHPYSDKGFGVWGVVGRATGGAVKYKMSGVLVQLLLEVMASYPPGSETRRLYEEIYSEVVEHLRWVVKAKASLYSPELETLLKRYEAAQDRFDPRADVFRHYFYVFQALRDEGGARRLRERLVEHYRENPGLRERYEKELRGLVERLASQLGYAGNAYRYRVVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D2</accession>
    <name>A1S0D2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753177.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1515"/>
    <dbReference type="EnsemblBacteria" id="ABL78912">
        <property type="protein sequence ID" value="ABL78912"/>
        <property type="gene ID" value="Tpen_1515"/>
    </dbReference>
    <dbReference type="GeneID" id="4601111"/>
    <dbReference type="KEGG" id="tpe:Tpen_1515"/>
    <dbReference type="eggNOG" id="arCOG04939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490634_0_0_2"/>
    <dbReference type="OMA" id="SEEGLAC"/>
    <dbReference type="OrthoDB" id="118511at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="89" mass="9541" checksum="ACF2AAF9CEDBA5AF" modified="2007-02-06" version="1">MDRADFARDAARVLEVARRIGVVDVGRLSAETGIPEGRVKLILLMLRDAGILSEEGLACSESACASCPLRAVCTARGGAKIYVRLRKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E2</accession>
    <name>A1S0E2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2341 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1526"/>
    <dbReference type="EnsemblBacteria" id="ABL78922">
        <property type="protein sequence ID" value="ABL78922"/>
        <property type="gene ID" value="Tpen_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1526"/>
    <dbReference type="eggNOG" id="arCOG03509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518410_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018765">
        <property type="entry name" value="DUF2341"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10102">
        <property type="entry name" value="DUF2341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2341" evidence="1">
        <location>
            <begin position="237"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="525" mass="57053" checksum="11435B3401B63003" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E4</accession>
    <name>A1S0E4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 and S6, chymotrypsin/Hap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1528"/>
    <dbReference type="EnsemblBacteria" id="ABL78924">
        <property type="protein sequence ID" value="ABL78924"/>
        <property type="gene ID" value="Tpen_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1528"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_2"/>
    <dbReference type="OMA" id="THGWVLE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="311" mass="32940" checksum="EECC67A7F582F469" modified="2007-02-06" version="1">MAEDLQERVIRAYEKVRDSVVSVTAVKVLDFLFVREPVSGLGSGVAVSEDGLVATNAHVVEGFEEISVTTPGGDHVRAEVVDVDPHYDIAFLRVERARLKPAELGDSDSLRVGQFVVAVGNPFGQLLGGPSLTFGVVSGLGRSLRAEGKIYENLIQTDAPVNPGNSGGPLVDLEGRVVGITTAMIPFAQGIGFAIPINEVKYALAQLEKYGRILRPWIGVYGLDVNPAIAYQLGLPRAAGVLVLRVVPGSPAARAGVKPGAVILKLDGSEVKGTGDLVSKLRQKEVGEKAVLEVFYAGTLRRLQVTVEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F7</accession>
    <name>A1S0F7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1541"/>
    <dbReference type="EnsemblBacteria" id="ABL78937">
        <property type="protein sequence ID" value="ABL78937"/>
        <property type="gene ID" value="Tpen_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1541"/>
    <dbReference type="eggNOG" id="arCOG00188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="MYRGEQV"/>
    <dbReference type="OrthoDB" id="25719at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="281"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="313"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="548" mass="60091" checksum="AFAC08AE4037AF4E" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G0</accession>
    <name>A1S0G0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753205.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1544"/>
    <dbReference type="EnsemblBacteria" id="ABL78940">
        <property type="protein sequence ID" value="ABL78940"/>
        <property type="gene ID" value="Tpen_1544"/>
    </dbReference>
    <dbReference type="GeneID" id="4600837"/>
    <dbReference type="KEGG" id="tpe:Tpen_1544"/>
    <dbReference type="eggNOG" id="arCOG00188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="CHCVSGP"/>
    <dbReference type="OrthoDB" id="25719at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="263"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="510" mass="55804" checksum="C0E291846673EF3B" modified="2007-02-06" version="1">MGEVVRVENLSFSYPNGRRALDSVSLSISQGEFVAVMGPSPSGKSTLVYALSGLIPHCVKGEIKGSVKVDGLDTREHPVAELAKRVGVILQDPEAQLLELRAVDEVALPLENLGVPAEEIRLRVGEALEMVGLRGYEERSPSELSGGEKQRLAIASVLALRPKVIVLDEPTANVDPPGTLQVYETLKRLNEEHGLTVIVVENKVEVARRYAKRAVLMEGGRVVADGEPSKVLRSDVLARLGLDARPARRPAKARAGSRGREVVRFEEVSFRYPDGTLALDHVDLTLREGEVVFLMGRNGSGKSTLVKHMNGLLKPSSGRVLVDGCDTRTCPTYRLSRIVGLVFQNPAHQIVGESVYDEIAMGLRHLGVGGDDVRREVARIARAFELEDKLDMIPEELSVGELKRLMIASIVAMRPKVLVLDEPMTGMTSAHSRRVLDTVLGMLGESSTIVVITHDPRLAFEYATRVVVMSRGRVVQDGSPEVLARCELLSSYLEVVPDVQVWRHNRDPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H9</accession>
    <name>A1S0H9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753224.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1564"/>
    <dbReference type="EnsemblBacteria" id="ABL78959">
        <property type="protein sequence ID" value="ABL78959"/>
        <property type="gene ID" value="Tpen_1564"/>
    </dbReference>
    <dbReference type="GeneID" id="4601522"/>
    <dbReference type="KEGG" id="tpe:Tpen_1564"/>
    <dbReference type="eggNOG" id="arCOG00237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_0_1_2"/>
    <dbReference type="OMA" id="LHGMNTY"/>
    <dbReference type="OrthoDB" id="49249at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="493" mass="53862" checksum="A8E91EA07E09E10B" modified="2007-02-06" version="1">MTNAEKRGFGKYLQAAGMPLAIFALLAISLMPTPPGLTVWGQRALAVFTFALILWLTSPIPFWLTSLLAIALLPITGGYSVTSTFQQLGQDVIWLMVCAFILSSAMEKTGIGKRLAYRLLLVFGGSPSLTLLGLILINLALAFVVPSTTARASIMLPIALLIAEAYNLKPGESNYGKILMMQQPMANNLSTSMILTATAPQILAWSFLKGMAGVEVPWLTWLVAQMPVILVMLVVLWIVGLKLFPPEIGSTASTEWRAKLKEELKSMGPLSREEKYTLAVFLLVLFLWATDQWHEVMFAGLSIPYALAAVIGASLLFLPKLGPLKKWGDAKIPWDLMIFSAGAYAVGLALNDSGGGQWLVMQLVNALGLQKGVDLFVAYALLLALMLYSHVFFSSKTTRTAIFIPLYIALARALGLPPVAIALPAAFVISWDLTFPYNCKPNLIYFGTGYFTMRDMIIYGLTICTIGYVLYLAVGWPWLNFLASIGMLPGWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J1</accession>
    <name>A1S0J1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753236.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1576"/>
    <dbReference type="EnsemblBacteria" id="ABL78971">
        <property type="protein sequence ID" value="ABL78971"/>
        <property type="gene ID" value="Tpen_1576"/>
    </dbReference>
    <dbReference type="GeneID" id="4600562"/>
    <dbReference type="KEGG" id="tpe:Tpen_1576"/>
    <dbReference type="eggNOG" id="arCOG01021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_5_1_2"/>
    <dbReference type="OMA" id="GAQYWKG"/>
    <dbReference type="OrthoDB" id="23746at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="56"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="427" mass="45365" checksum="C0DC241ECC7A32B2" modified="2007-02-06" version="1">MSATQSQQKGKFAFDVKLVAVAIIALIVGVAIGAAIFGGAAGQAPGAAQQAPKKVYTIGFTLPLTGELSSIGKIWEKVVYLAIDDLNKEAQAYGFNVEFKAVILDDGTTPEKALQNVQTLAQQGIKVIIGPAASSQVKAVKGFVDSNQIVLISPSSTAPTLAIPGDFIFRTVGSDAGQARVLATLAYQEGARKVIVFHRNDEYGNAFADFFKKYFSELGGSSIDVPYQTGLSDYAAEVASLASKVQSEKVDAVVLISFDTDGGNILSHAAESPVLSSVRWFVSEGPHGAAELKAPAVGAFAAKTKLLGTRPLFIGNPLYEDFKKRLKEKYGVDASVFCDTLYDAVMLAGWAMLRAGSSDGNAIRSALIEVAKHYYGVSGWAIFDEAGDKAYQDYGVWAIVKTDGGYDFKDVGVYERGSIVFTAKPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N6</accession>
    <name>A1S0N6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterio-opsin activator, HTH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753281.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1621"/>
    <dbReference type="EnsemblBacteria" id="ABL79016">
        <property type="protein sequence ID" value="ABL79016"/>
        <property type="gene ID" value="Tpen_1621"/>
    </dbReference>
    <dbReference type="GeneID" id="4601024"/>
    <dbReference type="KEGG" id="tpe:Tpen_1621"/>
    <dbReference type="eggNOG" id="arCOG02272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192675_0_0_2"/>
    <dbReference type="OMA" id="LERDYCT"/>
    <dbReference type="OrthoDB" id="78391at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="26412" checksum="030B10D4267CA084" modified="2007-02-06" version="1">MTTLRPYKVYMRPQKSLLSELTNLPGIEITVLNIIQSGSTYKTLAHATTSGNLKFYQVLEEMKFKNEILDFKVLNKNKQSVTFILERDYCTFYDYTLGTGRFILFPYVIKKGTRKFFIISEEEPSILLDRLKKYGTVTRMEKVLLTDALKDSYALLMRTDLLSKLTPLQRKILSKAIIKGYFDWPRKYSLSDLSQELGISKATLAEHIRRSESKILKYLLEGGEGFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q0</accession>
    <name>A1S0Q0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753295.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1635"/>
    <dbReference type="EnsemblBacteria" id="ABL79030">
        <property type="protein sequence ID" value="ABL79030"/>
        <property type="gene ID" value="Tpen_1635"/>
    </dbReference>
    <dbReference type="GeneID" id="4600914"/>
    <dbReference type="KEGG" id="tpe:Tpen_1635"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="LDPINTI"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="315" mass="34598" checksum="05194F7BEDE99622" modified="2007-02-06" version="1">MSLLEVRDLVVKYATRQGEVEALGGVTLSVNPGEVLGVVGESGSGKSTLGLAILRLLPRYARVERGQVLYNGADLLKLGEEELRRIRGREISIVFQDPYSSLNPVMRIGDHFVELFEEHGYGYSREEALRRAGDILERMGVPRERLSDYPHQLSGGQRQRVAIGLALALNPKLVVADEITTALDALVEAQIMDLLREVKKEYDTSILFITHNMGLVAELADRVAVMYAGKLVELGSTGEVVGDPLHPYTKALLAAVPSIGGSREVKPIPGDPPDMRNPPRGCRFHPRCPFATEKCRAEEPVPRDRGGRIVACHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q8</accession>
    <name>A1S0Q8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1643"/>
    <dbReference type="EnsemblBacteria" id="ABL79038">
        <property type="protein sequence ID" value="ABL79038"/>
        <property type="gene ID" value="Tpen_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1643"/>
    <dbReference type="HOGENOM" id="CLU_2565931_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="8487" checksum="E74D5136FDD80B6B" modified="2007-02-06" version="1">MGYSDEVAVSHGSKRGVPARPGEHRSPGAARGVGESASSSGRDPADYATFVRKLVLSFDSREKLIKGEAHLLVLGGFEGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R6</accession>
    <name>A1S0R6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753311.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1651"/>
    <dbReference type="EnsemblBacteria" id="ABL79046">
        <property type="protein sequence ID" value="ABL79046"/>
        <property type="gene ID" value="Tpen_1651"/>
    </dbReference>
    <dbReference type="GeneID" id="4601728"/>
    <dbReference type="KEGG" id="tpe:Tpen_1651"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126379_1_0_2"/>
    <dbReference type="OMA" id="DGHCVFY"/>
    <dbReference type="OrthoDB" id="85209at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="138" mass="15927" checksum="15C4878A840F8410" modified="2007-02-06" version="1">MEELKIDCRVNGRLCGKCCYKAVVPLTRRDIERITSRGYRFEDFAEYRAGVPVLKNVDSHCVFLDPTTNACTIYEDRPTACRLYPLAYSPKLWVHVDPACPKAGEVPKEAVVRLASRVLDYYEEVKRDWLLDSQYEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W7</accession>
    <name>A1S0W7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1702"/>
    <dbReference type="EnsemblBacteria" id="ABL79097">
        <property type="protein sequence ID" value="ABL79097"/>
        <property type="gene ID" value="Tpen_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1702"/>
    <dbReference type="eggNOG" id="arCOG07347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1912444_0_0_2"/>
    <dbReference type="OMA" id="CNRELNI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="14586" checksum="38F8C2EC4D56BD30" modified="2007-02-06" version="1">MVAVKIDLEELARAVNWRGKRADYLLVGEGAVAVVEETERAKIDDVRKLESTVEALLRGPLAAAVPGLCNPFRIVAVLHSKRGVDSMVYRELMSQTRKRGVVYRAANCQQQLERVLREHGFSESSAAPPNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y7</accession>
    <name>A1S0Y7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753382.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1722"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79117">
        <property type="protein sequence ID" value="ABL79117"/>
        <property type="gene ID" value="Tpen_1722"/>
    </dbReference>
    <dbReference type="GeneID" id="4601747"/>
    <dbReference type="KEGG" id="tpe:Tpen_1722"/>
    <dbReference type="eggNOG" id="arCOG01408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_5_2_2"/>
    <dbReference type="OMA" id="WREDWDW"/>
    <dbReference type="OrthoDB" id="59830at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="394" mass="45627" checksum="84B25D27AB3B02B8" modified="2007-02-06" version="1">MKQVQEFSHKGKYCKKLRIAFVHNYYIHYRVPLFKALSRVFHVKFFFDDVYEYVKKPEKELDFVINKGPRIKGIRLPVTLLFHLLKQRPHLVIAGDSTYPSTLIAFLTSKMLRAKFILWEERWFWHSSLLSNLLWPFSRTVALKADALIVPGTLSKEFYKNIGVEKGRIFVAPNASYVDINEEIKNRARALRRKLGLDNKIVVLYIGRVIPLKGVHLILKALTKINEYNLHLLIPGTFVDPWYKRLLDDIVKASKLESKVTMLSLKFVRVEDRGIYYELADIVCYPSYYEAWGMVVNEAAYAGKPVISTRTCAAAYDILFGHPELVIPPGNVEELAKSLKLLAMDANKRKAIGMELKRLISEKYSYEEMLKGFLKAIKYTLVNQLTEQSQNKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S105</accession>
    <name>A1S105_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753400.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1740"/>
    <dbReference type="EnsemblBacteria" id="ABL79135">
        <property type="protein sequence ID" value="ABL79135"/>
        <property type="gene ID" value="Tpen_1740"/>
    </dbReference>
    <dbReference type="GeneID" id="4601765"/>
    <dbReference type="KEGG" id="tpe:Tpen_1740"/>
    <dbReference type="eggNOG" id="arCOG03159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179751_0_0_2"/>
    <dbReference type="OMA" id="VGYHEPL"/>
    <dbReference type="OrthoDB" id="119827at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="6">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="100" mass="10804" checksum="974E0B8C20097E1E" modified="2007-02-06" version="1">MGKVVSILKKHRKAALAVLAMVLVSPVFGVWLANLVGYHEPLDLAAEALGLNETTEEINWTPFLDYTVPGLPDWLGYIVSGFLGVAVVLALGYLLLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1S135</accession>
    <name>A1S135_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753430.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1770"/>
    <dbReference type="EnsemblBacteria" id="ABL79165">
        <property type="protein sequence ID" value="ABL79165"/>
        <property type="gene ID" value="Tpen_1770"/>
    </dbReference>
    <dbReference type="GeneID" id="4601947"/>
    <dbReference type="KEGG" id="tpe:Tpen_1770"/>
    <dbReference type="eggNOG" id="arCOG01263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_2"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="OrthoDB" id="38707at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="234" mass="25585" checksum="74C5EE3BA4E9AA98" modified="2007-02-06" version="1">MASAVITGASSGIGRELSAEACRRGYRVLGIGRNEAALRELASEHPDCFAYLVLDLSDPASAERVAEFVSSEFRSLSLLVNNAGYGVGRGILEMTPREILDTVNVNFAAPLLLTKLLLPYMERSGTVVNVVTAGIHVLMTRLPLYGATKIALHYASEALRRELSDRGVNLLEVFPGVVETSFHERAGLGRQKGYPARRVAVEILDAVEKRKKKLYVPRYLAALRLLGPYLPALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S166</accession>
    <name>A1S166_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1801"/>
    <dbReference type="EnsemblBacteria" id="ABL79196">
        <property type="protein sequence ID" value="ABL79196"/>
        <property type="gene ID" value="Tpen_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1801"/>
    <dbReference type="eggNOG" id="arCOG02113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891550_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="134" mass="14411" checksum="1268F9FBF7D2D2C7" modified="2007-02-06" version="1">MVGVEELFTPERRAAFEKFLDTLVKLDEYGLLDAVNGLVDPELIGRLAEILITPSTLKLLDRVDELVGLLGEVDVDAVKSNVGTLKAVLEALQKEPKPVGLAGLLRALSDPEVQRGLGVAIEVLKALGRASQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S184</accession>
    <name>A1S184_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase (B12-independent)</fullName>
            <ecNumber evidence="2">2.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753479.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1819"/>
    <dbReference type="EnsemblBacteria" id="ABL79214">
        <property type="protein sequence ID" value="ABL79214"/>
        <property type="gene ID" value="Tpen_1819"/>
    </dbReference>
    <dbReference type="GeneID" id="4602056"/>
    <dbReference type="KEGG" id="tpe:Tpen_1819"/>
    <dbReference type="eggNOG" id="arCOG01876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878856_0_0_2"/>
    <dbReference type="OMA" id="HVCGRIS"/>
    <dbReference type="OrthoDB" id="84519at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="132"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="35423" checksum="5C6700B0B23192AC" modified="2007-02-06" version="1">MKVATTLVGSFPLDYSRENIARALKDQVDIGITYPVLPQLRDFVYMFIEPLVKKGVVVREGLGYRLRGDVSSVEPETPEDMSYAADVAEDLGARYRLAFTGPFTVASRITPEGGRIGDIRTSLLADREGFQAVLEYVVETAREVASTLNPFIVCVDEPVLSVIVGSKSVMFGYTAEEITRALDSVLARFRSPMRGVHVCSRLPPLLKTVLLQLSNANFLDHEHSDIPENRAYYQASELRESGKVLGYGVVSSRNTSVERLEDVVALARDALERYGESLAFIKPDCGFGGMKGYLQGREYEEIVLKKLRVLVEASRGLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B0</accession>
    <name>A1S1B0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1845"/>
    <dbReference type="EnsemblBacteria" id="ABL79240">
        <property type="protein sequence ID" value="ABL79240"/>
        <property type="gene ID" value="Tpen_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1845"/>
    <dbReference type="HOGENOM" id="CLU_2021629_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="122" mass="13916" checksum="FF5B09E81D8B197D" modified="2007-02-06" version="1">MPFEYAGCKVERQGNAYILVCPAGRAIVKKDEVVLYTPEGAVRVFSPDVHAIRGKISAVEPVKRGLPELLSEIGSEASAESPEELYNDIRLYEETEAAPERLWREYAETERRLRSLRSWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F5</accession>
    <name>A1S1F5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751410.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1890"/>
    <dbReference type="EnsemblBacteria" id="ABL79285">
        <property type="protein sequence ID" value="ABL79285"/>
        <property type="gene ID" value="Tpen_1890"/>
    </dbReference>
    <dbReference type="GeneID" id="4600349"/>
    <dbReference type="KEGG" id="tpe:Tpen_1890"/>
    <dbReference type="HOGENOM" id="CLU_1551900_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="172" mass="18775" checksum="EE4F083F87046075" modified="2007-02-06" version="1">MELEELLDRMQELLHFVEQDVSRNNPPTPQLAVLSLSAVINKLLGTPPTGEVVYRGRHAVLTFAKTTQLSDEAKRAVIEILEIFERVSSECLGNVAGSDPFTREWVKTTLLRGKASATVIQVNISGNTVVMPPENLLAELQIVVTSARQAYSFTRSVTKVIEVVGGAEAPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA6</accession>
    <name>A1RWA6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase, NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0076"/>
    <dbReference type="EnsemblBacteria" id="ABL77486">
        <property type="protein sequence ID" value="ABL77486"/>
        <property type="gene ID" value="Tpen_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0076"/>
    <dbReference type="eggNOG" id="arCOG00247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_1_2"/>
    <dbReference type="OMA" id="AWVQSTT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="286" mass="31972" checksum="9694E2CA34BDEFB7" modified="2007-02-06" version="1">MRLGFIGTGAMGFPMAARLARTGHELFVWNRTIEKARPLEQYGARVASSLDELSRVAEVVFVMVSDDEASREVLSAVLREGRPRIIVNHSTVSPMYTREAVEEAKRRGVEYLAIPVMGGPSDIERGEGVCIVGGREEVFREVEPLTSAYCKEHVLVGSQENASVIKLALNSMYFSALEALAEALLLVEAWNVEPKVFFDAASRLWLRVVVDRYAKRLLDEKYPTSFQLRLAAKDLHYAVFSGYHKGQPLPMLSELAKTFLEASTIGGLGRRDYTRIYYFLKRGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC2</accession>
    <name>A1RWC2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751767.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0092"/>
    <dbReference type="EnsemblBacteria" id="ABL77502">
        <property type="protein sequence ID" value="ABL77502"/>
        <property type="gene ID" value="Tpen_0092"/>
    </dbReference>
    <dbReference type="GeneID" id="4601085"/>
    <dbReference type="KEGG" id="tpe:Tpen_0092"/>
    <dbReference type="eggNOG" id="arCOG04123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142667_0_0_2"/>
    <dbReference type="OMA" id="MPREMLV"/>
    <dbReference type="OrthoDB" id="90815at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014450">
        <property type="entry name" value="UCP008210"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09921">
        <property type="entry name" value="DUF2153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008210">
        <property type="entry name" value="UCP008210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="136" mass="16014" checksum="B92331C4CBF3AE97" modified="2007-02-06" version="1">MSEFVKLFAANLTNWVEAQKAFLDTVEAVEKNLENADRLELILTTRAAFSHMVKTIEAFDKWLQDPFIVGHMPREMLLDVQRSVWEILKKLLELDIRHTTAFRDMLLKLSEDGKLNPVFFMPRGEQKPEERFRVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD2</accession>
    <name>A1RWD2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0102"/>
    <dbReference type="EnsemblBacteria" id="ABL77512">
        <property type="protein sequence ID" value="ABL77512"/>
        <property type="gene ID" value="Tpen_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0102"/>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550474_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="82" mass="9394" checksum="115D81BD3E39D3F6" modified="2007-02-06" version="1">MTQRPELSKSFYITERGDYTSVTKIVSVKLPVGLIDALDELIQKGYFQNRSDAIREAIRKLLTNYRELDSRKISSGLMVGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD9</accession>
    <name>A1RWD9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751784.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0109"/>
    <dbReference type="EnsemblBacteria" id="ABL77519">
        <property type="protein sequence ID" value="ABL77519"/>
        <property type="gene ID" value="Tpen_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="4601130"/>
    <dbReference type="KEGG" id="tpe:Tpen_0109"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063044_1_1_2"/>
    <dbReference type="OMA" id="FGPAIMF"/>
    <dbReference type="OrthoDB" id="89093at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="230" mass="25431" checksum="7E0DB119AF760456" modified="2007-02-06" version="1">MSVEEIFEKALSENRKNLSLGEAFAVCEYYGLPLLGYRFIGVDEEVPEALGLSYPVVVKVDSPDIVHKTEYGGVKTGIKSREELVKAIEDIKRSVKAKNPNARINGFIVQEQVSNAHEVIIGGLKDEQFGPVIAFGLGGVLVEILRDVAFDIAPITPQEARDLITRIKGYQILEGYRGIPKANIDALSEVLSKASRMFADIAKYVKEMDLNPTFVSSEWVKIADARFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF3</accession>
    <name>A1RWF3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0123"/>
    <dbReference type="EnsemblBacteria" id="ABL77533">
        <property type="protein sequence ID" value="ABL77533"/>
        <property type="gene ID" value="Tpen_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0123"/>
    <dbReference type="eggNOG" id="arCOG01006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094088_0_0_2"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="266" mass="28812" checksum="F1CBF00C4A5AB14E" modified="2007-02-06" version="1">MYIDPRWLIVILGSSVSFSVLSPVIHARRLNFFAATLPHSSLLAVSLGYLLSFLLGYSPTLWAIPISVALSFLLVVLIHRGVSEDSATSAFVSFSVSASVAAMYYILTKFPSEVSLWSYILGDPLLVTWEDVAVTVVVTAVATLSTLLIYMKEVVIGLDRDFSQLLGINVNLHDYLVVFVLTLVSISLLKVVGFVLEHVVLLLPATVSVQLAKSAKEFLGYSLLVSTVSGLLGLFTSIYANVAPSAMYGFVMLGLYLAVLLRGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ2</accession>
    <name>A1RWJ2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751837.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0162"/>
    <dbReference type="EnsemblBacteria" id="ABL77572">
        <property type="protein sequence ID" value="ABL77572"/>
        <property type="gene ID" value="Tpen_0162"/>
    </dbReference>
    <dbReference type="GeneID" id="4601271"/>
    <dbReference type="KEGG" id="tpe:Tpen_0162"/>
    <dbReference type="eggNOG" id="arCOG02170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926290_0_0_2"/>
    <dbReference type="OrthoDB" id="140227at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="218"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="33152" checksum="8DA8D132CF838DA4" modified="2007-02-06" version="1">MRAVYVALAAAYVVAALVVASYGVTGYSFPSMNMENVFTWIAVVFLVLLGYEVARNRREILEIILEIFRRRPARDKDYTPRISTLGLIFLAMLPVLLAVILERNREERGLMNIGTGVQSNISEPVSALPGNLTAPLASSTGTSVGGSLVGVFAPLPLVLLGFAVLVALSLLLAYREALGERKEALGAPQILVKEELKASLTRIEDYPEGDVRLEIVRLYNSLCNAVNEKGARLEKSWTAREIMRFLSDTMPFIPARPLEKLTELFELALYSRRPLTERDRENAVRSLREILSAIDSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN0</accession>
    <name>A1RWN0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-fructose 1,6-bisphosphatase</fullName>
            <ecNumber evidence="3">3.1.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751875.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0200"/>
    <dbReference type="EnsemblBacteria" id="ABL77610">
        <property type="protein sequence ID" value="ABL77610"/>
        <property type="gene ID" value="Tpen_0200"/>
    </dbReference>
    <dbReference type="GeneID" id="4600809"/>
    <dbReference type="KEGG" id="tpe:Tpen_0200"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OMA" id="MARCFAG"/>
    <dbReference type="OrthoDB" id="99063at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="290" mass="30506" checksum="53CBE6FCEB9B1E2D" modified="2007-02-06" version="1">MSREILDVVRQASKVAAEAAIKALEEGVGAREEGRGSGGDISLRGDILAERSAIEYLEKRIGDFSVVSEEIGEKTYGKGGGYRFIIDPIDGSRNYKRGTPFFAVSVAAAEGETLEDVIAGAVYAPLLGMEFYALAGGGAFLNGRRLRVPPGGDTGAVEGKVVAISSTPKAFFLPYVFALNLSLRGAVVRMLGSASLEVSMVASGGVDAYIDAWGTMRVVDVAAATLVAREAGAYVVLGGRLGTPPRISLDERLYILVASSKILAEHVAAIYEESLGHPIEELFRAFGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN5</accession>
    <name>A1RWN5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751880.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0205"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77615">
        <property type="protein sequence ID" value="ABL77615"/>
        <property type="gene ID" value="Tpen_0205"/>
    </dbReference>
    <dbReference type="GeneID" id="4602216"/>
    <dbReference type="KEGG" id="tpe:Tpen_0205"/>
    <dbReference type="eggNOG" id="arCOG01383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_0_2"/>
    <dbReference type="OMA" id="NGFDNEY"/>
    <dbReference type="OrthoDB" id="74894at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="339" mass="39013" checksum="2538CDD096B52797" modified="2007-02-06" version="1">MYPKVSIVIVNFKGTEALKKCLRSVFETEYPDYEVIVVDSLTDNVEKALRDEFGSKENLKIIHFDSNIGASGSHNVGAMASDPNSKYLVFLDNDVEVEKDWLKRLVETAEESPRIGCVQAKVISKSNEGRMDHAGLALDLTATWLSTYGFREEIFQRPIELFVASSAALLTPRELYFKVGGFDSSYFIYDDDTDYTWRVRLQGYISLLETRARVYHEDKISSRLRFDKLYFGYRNRLQNIVKNMDAKNMVVSLLVTLYLGYLVTVLLALAGRIRETAAYFLSSTSVVFSLPRLMWKRKLVSLKRRVPDSYFEKKGFLRKDLLGTIYMTRALLIRSVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP7</accession>
    <name>A1RWP7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="8" type="ordered locus">Tpen_0217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751892.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0217"/>
    <dbReference type="EnsemblBacteria" id="ABL77627">
        <property type="protein sequence ID" value="ABL77627"/>
        <property type="gene ID" value="Tpen_0217"/>
    </dbReference>
    <dbReference type="GeneID" id="4601810"/>
    <dbReference type="KEGG" id="tpe:Tpen_0217"/>
    <dbReference type="eggNOG" id="arCOG04125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_2"/>
    <dbReference type="OMA" id="PKPGLSH"/>
    <dbReference type="OrthoDB" id="52581at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="6">
        <location>
            <begin position="8"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="7">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="349" mass="36990" checksum="8F24BE9A39303086" modified="2007-02-06" version="1">MIEIDGSMGEGGGQLLRYSIALSAIMNVPLRIYNIRAKRDPPGLRPQHLTALKFIAELVKGEAEGLRVGSTEVKFVPRLRRPAPGKYVADIGTAGSVTLLLQASLPVLLAAEGKVGLEVRGGTSVRWSPPYRYFENVLIPLISKFGAKISSKLLREGFYPEGGGAVYVETTPGYPLEPINLTAKSTPGPVEGASYVGNLPCHIAERQARSARERIESAGFNVGKVNVVCNQPATGRGSGIVLWARVGEGVVGSDALGERGKPAEDVGREAAERLLPILKAGAPVDPHASDNLVIYMSLARGESAILTTELTSHAETALELCRQITGATYTVERTGNGVLIKVKGVGYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR1</accession>
    <name>A1RWR1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0231"/>
    <dbReference type="EnsemblBacteria" id="ABL77641">
        <property type="protein sequence ID" value="ABL77641"/>
        <property type="gene ID" value="Tpen_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0231"/>
    <dbReference type="eggNOG" id="arCOG04069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_1_0_2"/>
    <dbReference type="OMA" id="FPIHKDL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="273" mass="30925" checksum="A98DCD1C5CD5DE08" modified="2007-02-06" version="1">MWPPLKPRLKRAVAVPSSTFSNLSEPARTFHVALLARAVTIFRVEEVAIYQESGHPCAELKRILDALEVPQYLRKYLVPRSREYRYLGLVPPLRSPSHLLRGEESEYREGYVVSRRGTKALVDVGLGNPVEAEVPTDAGRRVTLRREGAGWRYVSPEEVKVYWGYRTKCYSSLREALEHYRSRGFLLVGTSRKAAPVSLVLEEIKREATAKNGVAVFFGTWNKGLQEISEEEGFELESFLDFIVNTAPIQGVKTIRTEEAVYISLAILNLNLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT9</accession>
    <name>RS13_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps13</name>
        <name type="ordered locus">Tpen_0259</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751934.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWT9"/>
    <dbReference type="SMR" id="A1RWT9"/>
    <dbReference type="STRING" id="368408.Tpen_0259"/>
    <dbReference type="EnsemblBacteria" id="ABL77669">
        <property type="protein sequence ID" value="ABL77669"/>
        <property type="gene ID" value="Tpen_0259"/>
    </dbReference>
    <dbReference type="GeneID" id="4601676"/>
    <dbReference type="KEGG" id="tpe:Tpen_0259"/>
    <dbReference type="eggNOG" id="arCOG01722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="OrthoDB" id="84219at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000306767" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <sequence length="157" mass="17399" checksum="D906DC10E2B8903F" modified="2007-02-06" version="1">MSGEFRYIVRVAGVDLPGDKALVYALADIKGIGVSTAQAVAKKLGLDPYRLLGTLSEEEVEKLSAALREIEKLGLPPWMLNRRKDPFLGVDRHLITSDLLITVRNDIEFMKKIKSYKGVRHMLGLKVRGQRTRTTGRTGLTVGVKRGKEKAQQQKGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW7</accession>
    <name>RPO5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit Rpo5</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpo5</name>
        <name evidence="1" type="synonym">rpoH</name>
        <name type="ordered locus">Tpen_0287</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751962.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWW7"/>
    <dbReference type="SMR" id="A1RWW7"/>
    <dbReference type="STRING" id="368408.Tpen_0287"/>
    <dbReference type="EnsemblBacteria" id="ABL77697">
        <property type="protein sequence ID" value="ABL77697"/>
        <property type="gene ID" value="Tpen_0287"/>
    </dbReference>
    <dbReference type="GeneID" id="4602097"/>
    <dbReference type="KEGG" id="tpe:Tpen_0287"/>
    <dbReference type="eggNOG" id="arCOG04258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_4_0_2"/>
    <dbReference type="OMA" id="PKIYHDD"/>
    <dbReference type="OrthoDB" id="123463at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="PTHR10535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="SSF55287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000074388" description="DNA-directed RNA polymerase subunit Rpo5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00025"/>
        </source>
    </evidence>
    <sequence length="80" mass="9010" checksum="12FA37D99583E056" modified="2007-02-06" version="1">MPRKFDVLEHELVPKHVLLSKEEANRLLKAMGLKKSELPWIYSTDPVARALKAKPGDVIMIIRQSPTAGESVAFRLVMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX5</accession>
    <name>A1RWX5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751970.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0295"/>
    <dbReference type="EnsemblBacteria" id="ABL77705">
        <property type="protein sequence ID" value="ABL77705"/>
        <property type="gene ID" value="Tpen_0295"/>
    </dbReference>
    <dbReference type="GeneID" id="4601304"/>
    <dbReference type="KEGG" id="tpe:Tpen_0295"/>
    <dbReference type="eggNOG" id="arCOG01021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_5_1_2"/>
    <dbReference type="OMA" id="KYIFRFV"/>
    <dbReference type="OrthoDB" id="23746at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ANF_receptor" evidence="4">
        <location>
            <begin position="73"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="425" mass="45013" checksum="FA2C0171F53EC076" modified="2007-02-06" version="1">MSAGNTVAGKSSLARVLAYIVIALLIGAFLGYFLRGYPAQQQAATTQTSVTTIPIGALVELSGDLSSYGKRDELAMQIAIEDVNNFAEKIGSPYRFKLLVEDSGTSPEQALSRIKTLAAQGVRAVIGLEASSEVAAVKQFADTNHVVVLSVGSTALSLAIPGDYILRVVPPDSVQSKALARLIYSLGYRNVAVIYRNDAWGVGLFEGFSARFKELGGNVAGVAYDPAAKDLSGEVNRLADIAASMGSNTAVLAITFEDDGIQIVKLAARNPVLSKLKWFGTDGVAQSTKLASEAGEELIALGGFPCTIFQPSENQRLADFVNRFRSRSGGEDPHAYAMNAYDAVWLVALSVMLTGSYSGDKLLSTIPLVAQNFNGITGPLTLDANGDRASGDYAIWRVVKTANGYDWQIIGWYSASSDSVTIQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY3</accession>
    <name>A1RWY3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751978.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0303"/>
    <dbReference type="EnsemblBacteria" id="ABL77713">
        <property type="protein sequence ID" value="ABL77713"/>
        <property type="gene ID" value="Tpen_0303"/>
    </dbReference>
    <dbReference type="GeneID" id="4601126"/>
    <dbReference type="KEGG" id="tpe:Tpen_0303"/>
    <dbReference type="eggNOG" id="arCOG07192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189637_0_0_2"/>
    <dbReference type="OrthoDB" id="123886at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="87" mass="10024" checksum="D35C16445FB89AF8" modified="2007-02-06" version="1">MTAISEAVLFILSELKRNNGSMNDKELFENVNRDLKYVGMEISFKEFNKLLLVLETRGYIRVEGSKKNLRVVRLLDTRMKRVEASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ1</accession>
    <name>A1RWZ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor synthesis domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0312"/>
    <dbReference type="EnsemblBacteria" id="ABL77721">
        <property type="protein sequence ID" value="ABL77721"/>
        <property type="gene ID" value="Tpen_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0312"/>
    <dbReference type="eggNOG" id="arCOG00214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_3_2"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="182" mass="19870" checksum="5D86C2E18C844991" modified="2007-02-06" version="1">MDKDLGSSIAEHKRKALRDLRYAFVTVSTSRFDAELRGERIPDVSVEVARELIERHGDKLVSYILVPDNPRLILEALVNLLERNDVDVVVFSGGTGPAPSDVTVETVEPLLEKRLAGFGDVFRGLSYQEVGSSAFLSNAIAGVVHGKLVFLLPGSPDAVREAFEKLILPESGHVLSIARGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX16</accession>
    <name>A1RX16_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752011.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0337"/>
    <dbReference type="EnsemblBacteria" id="ABL77746">
        <property type="protein sequence ID" value="ABL77746"/>
        <property type="gene ID" value="Tpen_0337"/>
    </dbReference>
    <dbReference type="GeneID" id="4601704"/>
    <dbReference type="KEGG" id="tpe:Tpen_0337"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311404_0_0_2"/>
    <dbReference type="OrthoDB" id="24521at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="943" mass="104602" checksum="3BD14A2CB4C52BC9" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX56</accession>
    <name>A1RX56_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ordered locus">Tpen_0377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752051.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0377"/>
    <dbReference type="EnsemblBacteria" id="ABL77786">
        <property type="protein sequence ID" value="ABL77786"/>
        <property type="gene ID" value="Tpen_0377"/>
    </dbReference>
    <dbReference type="GeneID" id="4602145"/>
    <dbReference type="KEGG" id="tpe:Tpen_0377"/>
    <dbReference type="eggNOG" id="arCOG00078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_2"/>
    <dbReference type="OMA" id="INMATHR"/>
    <dbReference type="OrthoDB" id="58340at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="26015" checksum="746D073342616DD5" modified="2007-02-06" version="1">MIRPVKVVEHEKFPGIYVVEYEDGTKKLATVNLAPGVKVYDETLIQHGDKELRTWNPYRSKLAGAIHKGITINPIKPGVKVLYLGVASGTTPSHVSDIIGPKGVLFGVEFAPRVMREFIEKVAVHRENVVPLLADARFPTKYAHVVELVDVVYADIAQPFQAKYVADNADMFLKSGGYIMMAIKAMSIDVTATPSETYKREITHLEERGYKVKEVKHLEPYDEAHAFVVAQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX60</accession>
    <name>A1RX60_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0381"/>
    <dbReference type="EnsemblBacteria" id="ABL77790">
        <property type="protein sequence ID" value="ABL77790"/>
        <property type="gene ID" value="Tpen_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0381"/>
    <dbReference type="eggNOG" id="arCOG04437">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399805_0_0_2"/>
    <dbReference type="OMA" id="ELVWASY"/>
    <dbReference type="OrthoDB" id="69766at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="196" mass="21098" checksum="A2896BF6807F82D9" modified="2007-02-06" version="1">MSNKYLFLVFTCAVLLLTVVAAPATSLSSSGSSSLAYKIDLSLLQPGDIILTRGKLASIIPGYYSHAILYIGNGMVVHAVSDGVVVQSIYDAISSDVSAVGIYRVKTSSYIKLAAVQWALSKVGYPYDYSWLVYPGGKQVYGSSYYCSELVWASYLAVGGPDLDANPGFTLKYGYNVAPQEIADDNDVYLVAFYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX76</accession>
    <name>A1RX76_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0397"/>
    <dbReference type="EnsemblBacteria" id="ABL77806">
        <property type="protein sequence ID" value="ABL77806"/>
        <property type="gene ID" value="Tpen_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0397"/>
    <dbReference type="eggNOG" id="arCOG00285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854240_0_0_2"/>
    <dbReference type="OMA" id="VYFLYRA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="325" mass="36206" checksum="F6DB45D04CFA9F4F" modified="2007-02-06" version="1">MYLRSKGMLLAERGLRVRLGALSAVSLKQGHIVVAGPTGSGKTNTVKVLLCGLKRRGIPFLVLDFHGEYGEFGRLEPGKDLSFNVLSTGDIEFVVDVFSTIFQITEPQWYFLVKALKKGSPPFRLSDIIALVDEEPVRDWREFEIKAAILRRLTILNEGVLGRTLNGDAPPEALFRGAFAVDLSVLPLKYRGLLALVLLKHLYDAAMARGKSQEIAHVTVIEEAWQVLPYRARWEAPSLAERLFLELRKFGEVVVAVAQRLDDLSERVLRNASLVVLHDASRADLQKLGCEDVERIPKLGRGHALVVSEGCLARRVRVKLYRGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX86</accession>
    <name>A1RX86_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752081.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0407"/>
    <dbReference type="EnsemblBacteria" id="ABL77816">
        <property type="protein sequence ID" value="ABL77816"/>
        <property type="gene ID" value="Tpen_0407"/>
    </dbReference>
    <dbReference type="GeneID" id="4601501"/>
    <dbReference type="KEGG" id="tpe:Tpen_0407"/>
    <dbReference type="eggNOG" id="arCOG00912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="43727at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="153"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="323" mass="36777" checksum="E4D62F7BA80395B5" modified="2007-02-06" version="1">MSGVLHLLTLRDYAADEIESLIRDAVLLKKLRKLGLKRLNLLNGRSVAMIFEKPSTRTRASFTVAAYELGAFPVSYSSSELQLARGEPVKDVARVLARYHDLIAARVYRHEDLEELARYSGVPVVNLLSDKYHPLQALADYMTIFEKKGRLSGVTLAFIGDGTDNVFNSLAIAGVKLGVRIRVAAPREYMPSEELLGRDVLSRIEVYEDPEEAVRDADVVYTDVFVSMGQEKEREYRLKVFLPKYQVNSQLLRSVGREDFIFMHCLPAHRGEEVTDDVIESPQSVVFDQAENRLHTSKSVLLHLLVPEWRKYMREEPLQPDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX96</accession>
    <name>A1RX96_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752091.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77826">
        <property type="protein sequence ID" value="ABL77826"/>
        <property type="gene ID" value="Tpen_0417"/>
    </dbReference>
    <dbReference type="GeneID" id="4600495"/>
    <dbReference type="KEGG" id="tpe:Tpen_0417"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="7598" checksum="5774C61F0571CE65" modified="2007-02-06" version="1">MQTISALSRLLASTLKGDGLYEARLVEALDAIEEFLASVHGATPQVEEDEELARELEEGVEELRELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF7</accession>
    <name>A1RXF7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_0478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0478"/>
    <dbReference type="EnsemblBacteria" id="ABL77887">
        <property type="protein sequence ID" value="ABL77887"/>
        <property type="gene ID" value="Tpen_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0478"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_9_0_2"/>
    <dbReference type="OMA" id="QVNPVNE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL77887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="588" mass="65448" checksum="3A0F6539518678D4" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH4</accession>
    <name>A1RXH4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Replicative DNA helicase Mcm</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752169.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0497"/>
    <dbReference type="EnsemblBacteria" id="ABL77904">
        <property type="protein sequence ID" value="ABL77904"/>
        <property type="gene ID" value="Tpen_0497"/>
    </dbReference>
    <dbReference type="GeneID" id="4601331"/>
    <dbReference type="KEGG" id="tpe:Tpen_0497"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_2"/>
    <dbReference type="OMA" id="NAYTCDR"/>
    <dbReference type="OrthoDB" id="3067at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="6">
        <location>
            <begin position="290"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="693" mass="77387" checksum="CFE5D96B08BE6CFB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL7</accession>
    <name>A1RXL7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0541"/>
    <dbReference type="EnsemblBacteria" id="ABL77947">
        <property type="protein sequence ID" value="ABL77947"/>
        <property type="gene ID" value="Tpen_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0541"/>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="LYCPESV"/>
    <dbReference type="OrthoDB" id="125632at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="87" mass="9473" checksum="8D561E608A2B3BD8" modified="2007-02-06" version="1">MSGTASKLLAKPVVGAVAAGSWRTERPVVDMSKCRLCGVCWLYCPDGVIEIDEDARLVKIDYDYCKGCGVCAAECPFKAISMVREHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN6</accession>
    <name>A1RXN6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease P protein component 4</fullName>
            <shortName evidence="3">RNase P component 4</shortName>
            <ecNumber evidence="3">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Rpp21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rnp4</name>
        <name evidence="4" type="ordered locus">Tpen_0560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752231.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0560"/>
    <dbReference type="EnsemblBacteria" id="ABL77966">
        <property type="protein sequence ID" value="ABL77966"/>
        <property type="gene ID" value="Tpen_0560"/>
    </dbReference>
    <dbReference type="GeneID" id="4600603"/>
    <dbReference type="KEGG" id="tpe:Tpen_0560"/>
    <dbReference type="eggNOG" id="arCOG04345">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079140_3_1_2"/>
    <dbReference type="OMA" id="RAIRITC"/>
    <dbReference type="OrthoDB" id="128960at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00757">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="123" mass="14458" checksum="D9F84336A9B59929" modified="2007-02-06" version="1">MKRDEREIRDLARQRIKRLLEFAAKVYRVEPRLADRYGELSLLIAKKARLHYPDFLKARVCRKCGAFLVVGFSARVRVKNRGKMKYIAVTCLRCGYTRRYPLKRSAVPPKPWYVLYGEVAGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ8</accession>
    <name>A1RXQ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shwachman-Bodian-Diamond syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752253.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0583"/>
    <dbReference type="EnsemblBacteria" id="ABL77988">
        <property type="protein sequence ID" value="ABL77988"/>
        <property type="gene ID" value="Tpen_0583"/>
    </dbReference>
    <dbReference type="GeneID" id="4600698"/>
    <dbReference type="KEGG" id="tpe:Tpen_0583"/>
    <dbReference type="eggNOG" id="arCOG04187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="59861at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="235" mass="26528" checksum="D6C4D5BA869243FA" modified="2007-02-06" version="1">MSGKRRLSIARLERGGKRYEIIVDVEKAWLYKNGEKLNVREIMEGEFIYYDANRGLKASESELKKVFGTDNIYSVAEIILKQGELLLTTEQRRELIEQKKRQIIELISRNAVDPRTNAPIPAKRIELALEEARVSIDPFKPAELQVPDVIKALRMTLPMKIMKAIMAVYIPAAYVGKAYHAVSKMGKVLRENYRSDGSLDLEIEVPAGLQSSIVEKVASLTKGSGDVKLIRMEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS7</accession>
    <name>A1RXS7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752272.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0602"/>
    <dbReference type="EnsemblBacteria" id="ABL78007">
        <property type="protein sequence ID" value="ABL78007"/>
        <property type="gene ID" value="Tpen_0602"/>
    </dbReference>
    <dbReference type="GeneID" id="4601222"/>
    <dbReference type="KEGG" id="tpe:Tpen_0602"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_2"/>
    <dbReference type="OMA" id="GPNIFGY"/>
    <dbReference type="OrthoDB" id="2789at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="704" mass="76317" checksum="B1FD59419E9C6E8D" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU9</accession>
    <name>A1RXU9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase, subunit M</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0625"/>
    <dbReference type="EnsemblBacteria" id="ABL78029">
        <property type="protein sequence ID" value="ABL78029"/>
        <property type="gene ID" value="Tpen_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0625"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OMA" id="MVKFCPK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="12336" checksum="690DEC2B3EBF1E97" modified="2007-02-06" version="1">MEFCPKCGGLMVPSVVNGKKVLRCSRCGYIVEKSNPGTYRVSHRIERTPKDVVTLVDVDVSVLPVVSFKCENCGNDKAYVYELQTRAGDEPATRFYICTKCRKVYREYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV3</accession>
    <name>A1RXV3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, SWIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752298.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0629"/>
    <dbReference type="EnsemblBacteria" id="ABL78033">
        <property type="protein sequence ID" value="ABL78033"/>
        <property type="gene ID" value="Tpen_0629"/>
    </dbReference>
    <dbReference type="GeneID" id="4601416"/>
    <dbReference type="KEGG" id="tpe:Tpen_0629"/>
    <dbReference type="eggNOG" id="arCOG01120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204247_0_0_2"/>
    <dbReference type="OrthoDB" id="123898at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="107" mass="12500" checksum="30B6978577BC308E" modified="2007-02-06" version="1">MVTEKSLELHARRAIAEKRVKLVKIKGAYGASELFLVESTDRKKVYVVIPGVYCSCPDFLFHVHLERSRKKCYHMVAVELAIREKKYVEEEIEEDRLTELVVKSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV7</accession>
    <name>A1RXV7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752302.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0634"/>
    <dbReference type="EnsemblBacteria" id="ABL78037">
        <property type="protein sequence ID" value="ABL78037"/>
        <property type="gene ID" value="Tpen_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="4601431"/>
    <dbReference type="KEGG" id="tpe:Tpen_0634"/>
    <dbReference type="eggNOG" id="arCOG02957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195007_0_0_2"/>
    <dbReference type="OrthoDB" id="130437at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="65" mass="6919" checksum="2778A44AE9BA170C" modified="2007-02-06" version="1">MSSKEKKSGEKKEGGKERKPTALPAAGLLTFYEEDIGGIKVRPELVIAGTFLLVILVLLAHAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY00</accession>
    <name>A1RY00_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TGS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752345.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0678"/>
    <dbReference type="EnsemblBacteria" id="ABL78080">
        <property type="protein sequence ID" value="ABL78080"/>
        <property type="gene ID" value="Tpen_0678"/>
    </dbReference>
    <dbReference type="GeneID" id="4601044"/>
    <dbReference type="KEGG" id="tpe:Tpen_0678"/>
    <dbReference type="eggNOG" id="arCOG00358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_1_2"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="21317at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="302"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="377" mass="42365" checksum="2A8E3F85CF859C7E" modified="2007-02-06" version="1">MPANLPAEAKSKWKRVMEARTPEEKLAALQEFLSAVPKHKGTERLRMQVTRQIAALRREIEERRKRRAGGGEQFFVEKEGDVQVVLIGSLGSGKTSLFRCLTGVSKPSQDRPVPGMVSWLGVYFQLVDTPGFLGFTDPGRLMALARNADALIVTLDSTANAEEQLAGMLRLLEENRISVKRPKAIVEIERRASGGVTVVGDLEGATVQDVVALLREYNVYHAVVRIQGRATLDDVEDAIFGSYVYRPTVAVLTKVDLAPNDHVKALKERLSNYGVPVYEFSAQRCRELRFDEIATYIFRELDLIRVYTRNPKTGNVEKRPVVVKRGAKVADVAKIIHSYLYENFRYAKVWRESFPFSPQRVGKDFVLEDGDIVEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY14</accession>
    <name>A1RY14_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752359.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0692"/>
    <dbReference type="EnsemblBacteria" id="ABL78094">
        <property type="protein sequence ID" value="ABL78094"/>
        <property type="gene ID" value="Tpen_0692"/>
    </dbReference>
    <dbReference type="GeneID" id="4602006"/>
    <dbReference type="KEGG" id="tpe:Tpen_0692"/>
    <dbReference type="eggNOG" id="arCOG01229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046378_0_0_2"/>
    <dbReference type="OMA" id="ECTIEER"/>
    <dbReference type="OrthoDB" id="39434at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="50502" checksum="05C657C2C903CEFD" modified="2007-02-06" version="1">MTLRGKRVKAIIMGAAGRDFHNFNVLFRNNPEYEIVAFTAAQIPFIDNRVYPPELAGELYPNGIPIYPESMLEELIKKFGVEKVFLSYSDLTAEEVAEKAGRVVAAGAEFVLPGVYETMISSRKPVIAVTASRTGAGKSTVSRRVARVLRELGVRFVVVRHPMPYGDLLKSAVQRFASLEDLERYNCTIEEREEYEPHIESGNVVYAGVDYEAILRRAEEEADLVLWDGGNNDWPFYKPDLYITVVDPTRPKDVVSSYPGYVNVRLADVIVVNKVNVVSPESVDLVEKSVRRINERAVIVRAKSELYVDKPELIRGKRVLVVEDGPTVTHGGLSVAAGYYAAVKYGAREVVDPRPYAVGTIKDAYEKYTHIGPVLPALGYSQQQLRDLEKTINSVQADTIVLGTPSNLLLYLNVNKPAVRVRYELEEISKPDLRDILVNFVEKKIPSARARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY15</accession>
    <name>A1RY15_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752360.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0693"/>
    <dbReference type="EnsemblBacteria" id="ABL78095">
        <property type="protein sequence ID" value="ABL78095"/>
        <property type="gene ID" value="Tpen_0693"/>
    </dbReference>
    <dbReference type="GeneID" id="4602008"/>
    <dbReference type="KEGG" id="tpe:Tpen_0693"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="553" mass="60099" checksum="15E2C181D5551E65" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY16</accession>
    <name>A1RY16_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0200 protein Tpen_0694</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0200 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0694"/>
    <dbReference type="EnsemblBacteria" id="ABL78096">
        <property type="protein sequence ID" value="ABL78096"/>
        <property type="gene ID" value="Tpen_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0694"/>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096329_1_0_2"/>
    <dbReference type="OMA" id="DYMIVNE"/>
    <dbReference type="OrthoDB" id="101213at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01111">
        <property type="entry name" value="UPF0200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022970">
        <property type="entry name" value="NTP_hydrolase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="196" mass="22042" checksum="DD9881EB46FE54DC" modified="2007-02-06" version="1">MMQSSGVRSKFLILVTGMPGAGKTVFSRVASSMGVPVLSMGDVVRSYAAERGLPMNDASLGKISLELREKFGRAVIAERTFERLASIDQGVVVIEGLRNLEELFYFRERASEAYLVAIHASQKTRYERLRKRGRKDDPLKWEEFLERDLRELSVGLGSVIALADIMLVNEGKTEEEFEEECREALQKLLARAEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY20</accession>
    <name>A1RY20_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0698"/>
    <dbReference type="EnsemblBacteria" id="ABL78100">
        <property type="protein sequence ID" value="ABL78100"/>
        <property type="gene ID" value="Tpen_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0698"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="475" mass="54496" checksum="183C65E27B4DABE1" modified="2007-02-06" version="1">MGREMMGCEKNVAAEEAGFEEFDEWFIRRKIEELLRKALFPSDGYRGLEATRNEVARELAEIRGNYARYGEAYVEYVGRLGEGEEKAIKEAEKAMREALEHVDELEIRRTGRAHWKAKLPGRSWRLYVHLKPSGYWEVEIRLHLRVVKLRLPDTLRLPPELLRAAQEGWIMGDASYRADREEVTMTTAQTWQVASFPGFWPGKEVAVYVDRIEIHETRVSVKWYVVVKGVRDAPRWWSLSKKEKQGIILAEIEAANRGEIDIFRALKLALLYVTDGMYPGSSNTARHVLDFAVGQNSRRVRTEGAVKVARLLYEKVPQLLAYMVASGCQKAEFLASLASVKPRHYAPRYLEVAGVKMTLLLVGASRALAAVVYVTEDNEETLRGFPERARREGLEVRKVKVSKGRWGYRAGQKELLRYADKRPIVYDTLIAFVEERLGAMPLNHPARPSVERLLERLKKARERALRKLGDQDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY35</accession>
    <name>A1RY35_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0713"/>
    <dbReference type="EnsemblBacteria" id="ABL78115">
        <property type="protein sequence ID" value="ABL78115"/>
        <property type="gene ID" value="Tpen_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0713"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="282" mass="31818" checksum="4F9F90FCC2B5F1A7" modified="2007-02-06" version="1">MKGVEEAIIEVKDVYYAYPGGYEALRGVTLEVRRGEFIAIMGENGAGKTTLIKHFNGILKPSKGTVKVKGIDTRTKSVAELSRIVGIVFQNPDHQLFEETVYDEVAFALRNFGYSEDVIERRVAWALNILDLQRYKDRSPYSLSVGEKRRLALASVLAYDPEVLVLDEPTAGQDYLQKEKISQTMNLLRLMGKTVVIVTHDVEFVTSYVDRIVVMSGGKVIAEGQPRKILANYAVLRKANLVPPQIVRVARALYGKSLLERYDYLSPEELFNDLRRIMGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY50</accession>
    <name>A1RY50_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase c2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752395.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0728"/>
    <dbReference type="EnsemblBacteria" id="ABL78130">
        <property type="protein sequence ID" value="ABL78130"/>
        <property type="gene ID" value="Tpen_0728"/>
    </dbReference>
    <dbReference type="GeneID" id="4600848"/>
    <dbReference type="KEGG" id="tpe:Tpen_0728"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579554_0_0_2"/>
    <dbReference type="OrthoDB" id="31834at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="1">
        <location>
            <begin position="323"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="471" mass="52197" checksum="1C1A328CC07E38D2" modified="2007-02-06" version="1">MNVEDFFKKAGLTPRPLQLETARELASQLPGNVGLEAPPGWGKTIAVLAALASAGALPAVWRVRTYPQARRISEDVAVANLKPFVAGGRERTCPLAGELRANVHHYCRYLKHKCPYFKLLVESPVRLGYVPSYEDLPPEVCRYYLQENVGADVYIATYNTGLNFGGVQTVVDEAHNAVSVQSMPLSKLREGLAELAQVAGSEELLDKVEKFDVVTNVRVYLEELTAALVEALEKGARPRSAPKVLSFIREAPFLWREGEEVYTLKVYRPRGPSLYVSATLTPVAHVFNVPVVSVPWQKKYTAAITTWLTTAYREYGPPLAREYNNLLFFLRRFFDRILVFATSRVAKTLSADTTNPEEWNRGVLLLLSHGRYAEGVDLPADCVVMAGAPYLPPYVSARLAAVGLKPDDVVAITTVQNVGRATRTPSASPFIVLADERYARLSIPYFDVVEVHSLKDLEAIITKLVRVHATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY81</accession>
    <name>A1RY81_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752426.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0759"/>
    <dbReference type="EnsemblBacteria" id="ABL78161">
        <property type="protein sequence ID" value="ABL78161"/>
        <property type="gene ID" value="Tpen_0759"/>
    </dbReference>
    <dbReference type="GeneID" id="4601080"/>
    <dbReference type="KEGG" id="tpe:Tpen_0759"/>
    <dbReference type="eggNOG" id="arCOG01882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232825_0_0_2"/>
    <dbReference type="OMA" id="RDYEKRH"/>
    <dbReference type="OrthoDB" id="117820at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="25141" checksum="B7CDA22C8E619916" modified="2007-02-06" version="1">MGTINRVRREIYRKLVHLALCSVLALPYFAALPPPLTVQVYYALGLLSASLLNSVVVKHGKLLAELEKLRRNVDSFAGSLSEELRQPLVLMEQTIARFYEFVSSQISILERDYEKREGYVGLLYGMIGASVSLLLSPCLTLYGVLALAFVDTSAALTDLLLGTGQKTARGSAVAFLVYASVLVALGVDPLRAAVSSLLTCIAEYLSPEDNLTVPVVATTLALLLGLPPRCPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA0</accession>
    <name>A1RYA0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0778"/>
    <dbReference type="EnsemblBacteria" id="ABL78180">
        <property type="protein sequence ID" value="ABL78180"/>
        <property type="gene ID" value="Tpen_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0778"/>
    <dbReference type="eggNOG" id="arCOG00691">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_2"/>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="499" mass="54405" checksum="EADDBD064D19BD41" modified="2007-02-06" version="1">MVRVKIAFVNAFVPWSPGSDSVVYSPSSGIVFVGSESAALKTGADLVVDVEGRVVVPGLVDAHMHLYSTALSLGRLDLRGVSSLEEIREVLKAAVKEAPPGSWIVGRGWDQEKLKERRMPTRFDIDDVTGDNPVVLIRVCGHVALLNTLALRKMGLLDSERGFGALLEKEGGVPTGIVYEDLVDYVVSRIPPPPPELLKSWILRVLSEYVSLGVTELHSMSVSLEELEAVQRVLTTLPIGYRAYVDPGIAELAAREYKGLVHGVKIFADGSFGARTAALREKYSDAETRGVLRISSEGILSVARRALSLGLQTAVHAIGDLAVAEALKAAEQLPRGSLRIEHASLTPPDILEKIGAVKPEIAVQPHFILSDTWITERLGERAEWVYAFKSLQARTRVYGSSDAPVEPINPWLGVYAAVERGCPEGLPVCRYTYGEKMSFVEALRLYTSYDQRRPSIVVLNSTRLPTSKKEYEALRAYAVLVGGKTVYRAPGARVPDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB4</accession>
    <name>A1RYB4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Starch synthase</fullName>
            <ecNumber evidence="5">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752459.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0792"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78194">
        <property type="protein sequence ID" value="ABL78194"/>
        <property type="gene ID" value="Tpen_0792"/>
    </dbReference>
    <dbReference type="GeneID" id="4601253"/>
    <dbReference type="KEGG" id="tpe:Tpen_0792"/>
    <dbReference type="eggNOG" id="arCOG01420">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_5_2"/>
    <dbReference type="OMA" id="MPSRWEP"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="4">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="331"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="553" mass="61879" checksum="0DB56C9D30DED448" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC0</accession>
    <name>A1RYC0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_0798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752465.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0798"/>
    <dbReference type="EnsemblBacteria" id="ABL78200">
        <property type="protein sequence ID" value="ABL78200"/>
        <property type="gene ID" value="Tpen_0798"/>
    </dbReference>
    <dbReference type="GeneID" id="4601259"/>
    <dbReference type="KEGG" id="tpe:Tpen_0798"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_2"/>
    <dbReference type="OMA" id="RPWLIAE"/>
    <dbReference type="OrthoDB" id="90493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="44"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="217" mass="23482" checksum="A5995CA39C3B724E" modified="2007-02-06" version="1">MSGKKPAGSNASCGDVLRALEEIAGEIAKCEKCPLSRSRTHTVPGEGNPCSGVVFIGEAPGRNEDLQGRPFVGAAGALLTELISLAGLSREEVFITNVVKCRPPNNREPREEEIAACLPYLLAQLRAIKPRLIVTLGKHSTKTILRMRGMSVDSIMSVRGKAYTVNAEWGQVTVFPTLHPAAALYNPAMRKVLEEDFRFLRGLLEGGGQRTLDSWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH2</accession>
    <name>A1RYH2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752517.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0851"/>
    <dbReference type="EnsemblBacteria" id="ABL78252">
        <property type="protein sequence ID" value="ABL78252"/>
        <property type="gene ID" value="Tpen_0851"/>
    </dbReference>
    <dbReference type="GeneID" id="4601976"/>
    <dbReference type="KEGG" id="tpe:Tpen_0851"/>
    <dbReference type="eggNOG" id="arCOG00952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078147_2_1_2"/>
    <dbReference type="OMA" id="NFGGFVP"/>
    <dbReference type="OrthoDB" id="101349at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02495">
        <property type="entry name" value="NrdG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="265" mass="29948" checksum="0AEFACFC37CEBB3C" modified="2007-02-06" version="1">MREHSEDVLLIGGWKETSMVDVLESVSFTLWLSYCNFRCPWCANSRLARGLEVRRATVDEIVSAVSRARAFVDYFHVTGGEPTLQYRRLEKLFERVKTEVGLPLSLDTNASIPSALEHLLRSVDVEHVAVDVKAPLDDPMLYSQVVGLPAKVAEKVVNDVRRGIAIAGRHARFLELRTLLVPGLLEPAHLERIARQLSEMELSAQRIAYVVQQFIPYEGVPEEYRGKPKTPRDVVASTAKRVAEILPGKFEVWYRTIEEGAVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI9</accession>
    <name>A1RYI9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752534.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0868"/>
    <dbReference type="EnsemblBacteria" id="ABL78269">
        <property type="protein sequence ID" value="ABL78269"/>
        <property type="gene ID" value="Tpen_0868"/>
    </dbReference>
    <dbReference type="GeneID" id="4602211"/>
    <dbReference type="KEGG" id="tpe:Tpen_0868"/>
    <dbReference type="HOGENOM" id="CLU_2313939_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="99" mass="10620" checksum="BE03EE375514A3A9" modified="2007-02-06" version="1">MNAKVVLVALLSVLAIALYWSPYPLIVGGYVLGGYPWLAPDGQPRSTMIALGVIFSVAFLSATAAMYVLAKKNEELGEEPATPVEQPRGAPSVTQEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM1</accession>
    <name>A1RYM1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752566.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0900"/>
    <dbReference type="EnsemblBacteria" id="ABL78301">
        <property type="protein sequence ID" value="ABL78301"/>
        <property type="gene ID" value="Tpen_0900"/>
    </dbReference>
    <dbReference type="GeneID" id="4602223"/>
    <dbReference type="KEGG" id="tpe:Tpen_0900"/>
    <dbReference type="HOGENOM" id="CLU_2079547_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="13265" checksum="331848E6EC16CDC9" modified="2007-02-06" version="1">MSQDVIEFELEEEALCEALARLGAEEVVVTMGEDILFRYPRDADVSQILSQVRSTLSILSDADPFLELRFQDRAIFVLRVDDYVAVASGRFQEGSAEDARLLLELLVNRARGELEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP6</accession>
    <name>A1RYP6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0925"/>
    <dbReference type="EnsemblBacteria" id="ABL78326">
        <property type="protein sequence ID" value="ABL78326"/>
        <property type="gene ID" value="Tpen_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0925"/>
    <dbReference type="eggNOG" id="arCOG01346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_3_0_2"/>
    <dbReference type="OMA" id="FVLTFKR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="12468" checksum="C82428E01D99A9B6" modified="2007-02-06" version="1">MRGGSRLRKLLRLPQGFITARTTSQTMSSSVFQRKDVPVVNVGKKGLDEGVIEEINNILESRGIVKVKLLKNFRETYGLSPEEVAVIISQRLGAEILGVRGFVIAFRKRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY4</accession>
    <name>A1RYY4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752679.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1014"/>
    <dbReference type="EnsemblBacteria" id="ABL78414">
        <property type="protein sequence ID" value="ABL78414"/>
        <property type="gene ID" value="Tpen_1014"/>
    </dbReference>
    <dbReference type="GeneID" id="4600687"/>
    <dbReference type="KEGG" id="tpe:Tpen_1014"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="LCLNCGW"/>
    <dbReference type="OrthoDB" id="6553at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="249"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="946" mass="105876" checksum="2AE0CB105C073872" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ23</accession>
    <name>A1RZ23_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoeA domain protein, domain I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752718.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1053"/>
    <dbReference type="EnsemblBacteria" id="ABL78453">
        <property type="protein sequence ID" value="ABL78453"/>
        <property type="gene ID" value="Tpen_1053"/>
    </dbReference>
    <dbReference type="GeneID" id="4600796"/>
    <dbReference type="KEGG" id="tpe:Tpen_1053"/>
    <dbReference type="eggNOG" id="arCOG00216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_2"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="179"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="397" mass="42303" checksum="7628A3BD182DBDB3" modified="2007-02-06" version="1">MHSVGRVLGEVSGLLSRPPAESVPVLDSLGRYSAETVVSSFKLPPAPKSVVDGYAVRAEDVEPASPGAPVTLRLLEGVLRPGSTEGFELPRGSAVRVETGALLPVGADAVVPVEDALEEDGRVHLFRRVARYENVSLPGEEYEEGVPIVRVGDRIQPHHLSALVLEGRSHVNVFRVEASILNVGDEIVGGTYFRPFTHFLVASWLRSLGFRVTDVSVAPDSPEAVAEWAGSRGEWLVVILGGTSMGGHDFTVKALESLGPEYIVHGLALQPGKTACVAVKGGRLYLAASGLPVAALSTLEVFLRPLLRRVGLKVPLLPRVKARLTRRITVKAGVVGFARVRVYREGGTLLAEPVMLGGSGALASLLRGNGYVIVPEGLEGYDEGEEVEVHLYGEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ76</accession>
    <name>A1RZ76_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752771.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1107"/>
    <dbReference type="EnsemblBacteria" id="ABL78506">
        <property type="protein sequence ID" value="ABL78506"/>
        <property type="gene ID" value="Tpen_1107"/>
    </dbReference>
    <dbReference type="GeneID" id="4601101"/>
    <dbReference type="KEGG" id="tpe:Tpen_1107"/>
    <dbReference type="eggNOG" id="arCOG00035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_0_2_2"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="101215at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005237">
        <property type="entry name" value="MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00289">
        <property type="entry name" value="TIGR00289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="229" mass="26148" checksum="15564DDE38D30B00" modified="2007-02-06" version="1">MRLAVLFSGGKDSHLAMFRAMRHHEVACLVTVESRNPESYMFHVPNIHLTELQAEAIGLPLVKVESEGRKEELEDLRRALELAVERYAVEGVVTGAIRSTYQSTRVQRVCRELDLWCFNPLWLEDEYEVYRELLENGFEVIVSGVFSYPLDASLLGRRVDWGLVEELGKLKERYGVSMAGEGGELETTVLDAPFYRKRVVVLEAEKVYSNYSGVYRVKRARLEEKGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ97</accession>
    <name>A1RZ97_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1129"/>
    <dbReference type="EnsemblBacteria" id="ABL78527">
        <property type="protein sequence ID" value="ABL78527"/>
        <property type="gene ID" value="Tpen_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1129"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_1_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="137" mass="15490" checksum="65F310F7C8BEB0A1" modified="2007-02-06" version="1">MEEVELIKRRMLRELVSRRGSTAGSARCPYERWARAPTFNDALSKCKVALADFWAEWCGPCRLTEPIFEELAAKYAGRVAFLKVNVDENPDLAVQYDVMSIPTMIVFKGGKEFKRFIGYSPLLARQLDLTLQGLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA4</accession>
    <name>A1RZA4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752799.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1136"/>
    <dbReference type="EnsemblBacteria" id="ABL78534">
        <property type="protein sequence ID" value="ABL78534"/>
        <property type="gene ID" value="Tpen_1136"/>
    </dbReference>
    <dbReference type="GeneID" id="4601391"/>
    <dbReference type="KEGG" id="tpe:Tpen_1136"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="PRTRNEV"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="334" mass="36720" checksum="4150FD9218F2D0C5" modified="2007-02-06" version="1">MYVVEARDLRKTYVSRKRRGLFRVEETRVEALKGVSLTAVKGEVLGILGPNGAGKSTLVKILATLLLPDSGYARIMGFDVVSERDEVRKLIGVSLSVEKGFFYKLTGRENLKYFGMLYGLDGKALEERVNEVLRDVGLQPYADKLYEEMSLGMKARLSIARALLTDPPVLILDEPTLGLDPVSARRIRSLLTSLAHSKGKTVLVTTHNMFEAEIICDRVAIISEGRILAVDSVDSLKKRVADSVFLEIRIAGLAGLQVQNVLRNVPGVEVRTAHRKGLGDKVVVSVPVAHAEEAFERVLHELRSAGLKVRSISIVEPSLEDVFIKLAGHRVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE6</accession>
    <name>A1RZE6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752841.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1178"/>
    <dbReference type="EnsemblBacteria" id="ABL78576">
        <property type="protein sequence ID" value="ABL78576"/>
        <property type="gene ID" value="Tpen_1178"/>
    </dbReference>
    <dbReference type="GeneID" id="4602044"/>
    <dbReference type="KEGG" id="tpe:Tpen_1178"/>
    <dbReference type="eggNOG" id="arCOG04311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_2_2"/>
    <dbReference type="OMA" id="TGWMQRG"/>
    <dbReference type="OrthoDB" id="96549at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="200" mass="22101" checksum="40F788C23DE594E7" modified="2007-02-06" version="1">MEWERLLSLRHLPRTGWVLRGVPASIAETVADHSFLTALVAIDVARRARERGFELELEKVLAMSILHDVAEAVTGDVVRYVKQLDEELFGKAEEEALRSLGLGAYSALLAELRRLESPEALVVKASDDLATIIEGSRLLRQGYAGVEEILDNVCRHVEELSARARREFGDSLADAVEAVLKDSGAYCPPRSQPRRGESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG2</accession>
    <name>A1RZG2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1194"/>
    <dbReference type="EnsemblBacteria" id="ABL78592">
        <property type="protein sequence ID" value="ABL78592"/>
        <property type="gene ID" value="Tpen_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1194"/>
    <dbReference type="eggNOG" id="arCOG01791">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_2_2"/>
    <dbReference type="OMA" id="WNFWISA"/>
    <dbReference type="OrthoDB" id="49237at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="256" mass="29179" checksum="CC95E7ABE967B43E" modified="2007-02-06" version="1">MIKDDSYALYYDLLYSHRDIGAEVDFLERVFRDYSLIPVKSVLDVGCGTGLHTIELGRRGYRAVGVDISQNMLEVARSKAREMTNVEFILSDATKLGFNSEFDAAIAMYGVVSYFVDDESLLGFLRSVRRAIKPGSVFVFDTWSLVGVLEKRVYYETPFSSFRKSGSQLAIKEENWRVDFLDQVAYAEIQWSILDLAKGEIDVFKHSLKLRLFTLREIVHVLRESGFELVKTFEDYSGKPFTESSSEIVVIARALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG6</accession>
    <name>A1RZG6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752861.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1198"/>
    <dbReference type="EnsemblBacteria" id="ABL78596">
        <property type="protein sequence ID" value="ABL78596"/>
        <property type="gene ID" value="Tpen_1198"/>
    </dbReference>
    <dbReference type="GeneID" id="4600390"/>
    <dbReference type="KEGG" id="tpe:Tpen_1198"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_0_2"/>
    <dbReference type="OMA" id="CMTAQRI"/>
    <dbReference type="OrthoDB" id="116057at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="133"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="214" mass="23047" checksum="33F1447B6FB84641" modified="2007-02-06" version="1">MFVAVIGGGRVGYSIAEFFSKRGDRVVVVEKNEKVCGELAGSLDVTVYCGDARSIRLLEEAGVNKADVLFAVSGSDSLNIRVASVAKKRFGVPRVVVRVNHAENKEKAAQSGADEVICLDEVAELFVRAVTEVDYRVLFKHGGFAVVEIRVLPDSPAIGKPLRELVEKGLKVVAVVRDGSLVEAGEDLVLEADDRLVLAGREEAINETRQDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH3</accession>
    <name>A1RZH3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752868.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1205"/>
    <dbReference type="EnsemblBacteria" id="ABL78603">
        <property type="protein sequence ID" value="ABL78603"/>
        <property type="gene ID" value="Tpen_1205"/>
    </dbReference>
    <dbReference type="GeneID" id="4600407"/>
    <dbReference type="KEGG" id="tpe:Tpen_1205"/>
    <dbReference type="eggNOG" id="arCOG04236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_2"/>
    <dbReference type="OMA" id="IMFDEPD"/>
    <dbReference type="OrthoDB" id="44302at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="26155" checksum="61877A10F61C8D14" modified="2007-02-06" version="1">MSGLEVRGLRVSVNGKLVLRGVDLEVPPGVIVGLIGPNGSGKTSLAYSIMGHPLYRVEEGEITLDGEVINHLKTEERASRGLFLVFQSPPEIGGLPVSVFLREVLARRGVEVGEEALSMYMREVGLGEEYLSRYVHEGFSGGEKRRFEFLQALLFKPKILIVDELDSGLDLEGVKSLTGKVRELAESGAGVLYISHNPLALRTLRPHRIVVLVDGKVRAAGGLELLDEVEEKGYQVVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ1</accession>
    <name>A1RZJ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1223"/>
    <dbReference type="EnsemblBacteria" id="ABL78621">
        <property type="protein sequence ID" value="ABL78621"/>
        <property type="gene ID" value="Tpen_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1223"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992473_0_0_2"/>
    <dbReference type="OMA" id="YVIADEF"/>
    <dbReference type="OrthoDB" id="95434at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="260" mass="28945" checksum="0F556823E6C9D2EF" modified="2007-02-06" version="1">MYMLVLWDLSQMKRRTVFVVMRVAWFALQVTVFGLAMNAIVRFRGVVAQGIDYYHFYLFGVYASMLFSISVSKAYDVAEEFEEGMIEYLLSLPMKRKILSLGRSIGGGLSAFLFTLPMYAVVVLLLGVYDPVAVLLSLLSALVFAVGVTGFVISVVLSLKSSDYTDIFFGVLDALIIRLSTVFYPAVVVAKIAPYYYAALVNPVSHFVDLLRTFFFFEEFKHLSVSSPYLMASYILGFAAGVSSAAIYIVEKRVEGGGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM0</accession>
    <name>A1RZM0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1252"/>
    <dbReference type="EnsemblBacteria" id="ABL78650">
        <property type="protein sequence ID" value="ABL78650"/>
        <property type="gene ID" value="Tpen_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1252"/>
    <dbReference type="eggNOG" id="arCOG02105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763953_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="147" mass="16269" checksum="C35AA08942631805" modified="2007-02-06" version="1">MSEGLLKGRRPFRVTEELREAVKGKVRKVLEPREEVALALIFGSFVRGGFARDVDLAVYLARSVDLYEAAEYSELLGRVLERETGLPFDVVVLNVAGEGLLARAMRGEKVLVRDQLLYHALRMLVAEAARFTGMTVPRAGSKPSHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM5</accession>
    <name>A1RZM5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752920.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1257"/>
    <dbReference type="EnsemblBacteria" id="ABL78655">
        <property type="protein sequence ID" value="ABL78655"/>
        <property type="gene ID" value="Tpen_1257"/>
    </dbReference>
    <dbReference type="GeneID" id="4600423"/>
    <dbReference type="KEGG" id="tpe:Tpen_1257"/>
    <dbReference type="eggNOG" id="arCOG00150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491464_0_0_2"/>
    <dbReference type="OMA" id="NWLWINP"/>
    <dbReference type="OrthoDB" id="16335at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="467" mass="50680" checksum="DC7ABD53D177913C" modified="2007-02-06" version="1">MSQQATKKKVSPLLIAGILVVIVVLVAAAFLLYKPPAAPTKPSKITFYTWWAGLERFAIDALIGNFTKNTGVAVEKTAVPGGAGVNAKYAIIALIMAGKPPEAFQVHCGPEMISYFMAAPHGKDDFVDLTSVGQEIGLTATPPGQVCMLSGRLYTLPVNLHRANLIFMNKQVLDKYGVKPPTTIDELNAACSKLKAAGVPCLVQAGADQFTVLHLWEQIFLAVAGPDKFIKFMYGTLDPNDPSITQATQIFLGYVDTFPPDWMALDWTSAVDRVVKGMGAFHVDGDWAVGLIYNVYPNVKMCPIDAITPDCNIIVAPFPGTQGIYNMVIDAVAVPKGPAQDLGVQFAKFFASRDGQKIFNPLKGSIACYADLPTDIYPTSIQKWEVSQYAASKSQVFSITHGALFSDVWSKLLSGAVLLAQTKQTSMWYSTVSDAIKLERQLWEQSGLFLGTPEKPFAGYLPPWAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN0</accession>
    <name>A1RZN0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752925.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1262"/>
    <dbReference type="EnsemblBacteria" id="ABL78660">
        <property type="protein sequence ID" value="ABL78660"/>
        <property type="gene ID" value="Tpen_1262"/>
    </dbReference>
    <dbReference type="GeneID" id="4600477"/>
    <dbReference type="KEGG" id="tpe:Tpen_1262"/>
    <dbReference type="eggNOG" id="arCOG03168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_0_0_2"/>
    <dbReference type="OMA" id="PKYLLTM"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="211"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="410" mass="47462" checksum="1024DEEB410E9C3A" modified="2007-02-06" version="1">MGFLRELTEEYLGSLKYVARIVPREVELPRESPDIVAVVGPRRSGKTFVMLRSVERDLAEGLQALYVPLDEPSLRRLDARRFAEMVREEYREGRVRLYMDEVQDWEDWDSKLRWLHDVKDFQLYVTGSSSALQSSEIPSRLRGRYVSRLVLPFSFREVARAELGAEPSTFRERGALKGLLREYLAWGGFPEVWLYRSREKAVALLETMFYRDIVERHRVREPEALLELAYVVLSSYASPVTWRSLARSLKGLGVEVDAKTAASYVEYMRQAFLVFVVKRFAYSERLRARSPRKVYVVDPAVASLFERPLDLGRRAENVVLVELVRRGCEPGYYVTSRGREVDFAAKCGGSLRLVEVCLEVEEGHVRKVAEAMRELRLREAELVSWDDEDEREVEGGRVRVVPLWKWLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN4</accession>
    <name>A1RZN4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1266"/>
    <dbReference type="EnsemblBacteria" id="ABL78664">
        <property type="protein sequence ID" value="ABL78664"/>
        <property type="gene ID" value="Tpen_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1266"/>
    <dbReference type="HOGENOM" id="CLU_488037_0_0_2"/>
    <dbReference type="OrthoDB" id="59852at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="558" mass="60419" checksum="471ECB75A7B0B955" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ2</accession>
    <name>A1RZQ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752947.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1284"/>
    <dbReference type="EnsemblBacteria" id="ABL78682">
        <property type="protein sequence ID" value="ABL78682"/>
        <property type="gene ID" value="Tpen_1284"/>
    </dbReference>
    <dbReference type="GeneID" id="4600592"/>
    <dbReference type="KEGG" id="tpe:Tpen_1284"/>
    <dbReference type="eggNOG" id="arCOG04004">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005145_0_0_2"/>
    <dbReference type="OMA" id="HLDIIRY"/>
    <dbReference type="OrthoDB" id="129110at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="723"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="766"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="802"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="870" mass="94323" checksum="2A71AD947A8C5761" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU3</accession>
    <name>A1RZU3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752988.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1326"/>
    <dbReference type="EnsemblBacteria" id="ABL78723">
        <property type="protein sequence ID" value="ABL78723"/>
        <property type="gene ID" value="Tpen_1326"/>
    </dbReference>
    <dbReference type="GeneID" id="4601565"/>
    <dbReference type="KEGG" id="tpe:Tpen_1326"/>
    <dbReference type="HOGENOM" id="CLU_1665590_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="17924" checksum="2DDAB0199059152D" modified="2007-02-06" version="1">MAVNLIDKCRYDSSRSINYYTERLAGLMSVVGQRRGGRSTHAYTKEVRRALETLVIYAWGKDELIPEIARAHIPDELRSRVARECFASLLEGLLRKFVEASKDISVGSRIELMNIVVSSIAEMAMHRSFPPYVEQFLSEVFPREPGKVENVVETGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV0</accession>
    <name>A1RZV0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752995.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1333"/>
    <dbReference type="EnsemblBacteria" id="ABL78730">
        <property type="protein sequence ID" value="ABL78730"/>
        <property type="gene ID" value="Tpen_1333"/>
    </dbReference>
    <dbReference type="GeneID" id="4601308"/>
    <dbReference type="KEGG" id="tpe:Tpen_1333"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="YNHLLAM"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="315" mass="34785" checksum="38506BB9E36566FA" modified="2007-02-06" version="1">MELAVETDRLVKVYRDRGSEVKALDEVSLRVPAGSIFGIFGPNGSGKTTLISILLGLILPTRGSARVLGYDVVKQSLSVRKRVGLLPEAFGLYEHMTALDNLVFFGLLDEVPKGEVEKRAREVLELVGLSNKAGAKVSTFSRGMIQRLGLAQVLMKDPDLVILDEPTMGLDPDGIELLKILVLGLRERGKTIMISTHLLHEVGNICTHAAIIRKGKVLAQGSLEEVTRELAEKQYSAYAVRRTDYSERLLEELRSLPEVIVTGHGGNTIRVLAKNDRVSALIEVAEKHGAAVEPLTYREVTWEDVYRFYQGGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW2</accession>
    <name>A1RZW2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78742">
        <property type="protein sequence ID" value="ABL78742"/>
        <property type="gene ID" value="Tpen_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1345"/>
    <dbReference type="HOGENOM" id="CLU_3003357_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="56" mass="6508" checksum="9C5B5021E582901A" modified="2007-02-06" version="1">MWRVVEEALRKAVEEEKLRRVEEALRGFAESMGDLPVEEWVEVVKASRRGRIPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW4</accession>
    <name>A1RZW4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753009.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1347"/>
    <dbReference type="EnsemblBacteria" id="ABL78744">
        <property type="protein sequence ID" value="ABL78744"/>
        <property type="gene ID" value="Tpen_1347"/>
    </dbReference>
    <dbReference type="GeneID" id="4600871"/>
    <dbReference type="KEGG" id="tpe:Tpen_1347"/>
    <dbReference type="eggNOG" id="arCOG03841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038930_1_0_2"/>
    <dbReference type="OMA" id="KICVEMG"/>
    <dbReference type="OrthoDB" id="53427at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="DUF917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="DUF917_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="DUF917_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="DUF917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="370" mass="39333" checksum="9AD407F100EFAE14" modified="2007-02-06" version="1">MIEVRTERQARALVLGATILGTGGGGSPSRGLAAILDALRRGLPVRIVDVGELPEEGFAVTAYNVGSIAPGAAAARERRIADPLRRAVEELEKVLGGRVAAIVPNEMGGGNTAAALSLAAELGVPAVDGDLVGRAAPEVHQCSAIVAGVPLCPSAAVTASGDVVVVKEYASIDDYEAVVRHLSVLGGGRAAVADTPMRRGEAARAVVRGTVSRAMRVGEEVLRAREEGRGPVAAATRALGGWRVFEGVVERYEWRDEGGFLLGEAVVRGTGEYRGRTLRTWIKNEHIMVWVDGEPAVMPPDLFSLLRDDGEPVTNTELKVGDKVHGVAAKAPEIWRTPEGLRYFGPRHFGFDYDYVPVEELVERALRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW5</accession>
    <name>A1RZW5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1348"/>
    <dbReference type="EnsemblBacteria" id="ABL78745">
        <property type="protein sequence ID" value="ABL78745"/>
        <property type="gene ID" value="Tpen_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1348"/>
    <dbReference type="HOGENOM" id="CLU_574432_0_0_2"/>
    <dbReference type="OrthoDB" id="133622at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="461" mass="50436" checksum="DB06947DCB02B380" modified="2007-02-06" version="1">MGMKAKTLALLVAVAVVAAYVMFTAPKMLPQQPATAPAEKPRNATVALRVHGVGALLVNGSSYVNTTLTLRVPAVLAINASAPKGWRLKTLMVNGSPVLPGVAKVYGNTTVEAVFERVFCTVYLRANVEGAGARVNGSLYRLPASVEVPCPSTVLVEPVAPGGYRPVNSSAALEVSSNSSLLLVFERSRRVARFVNVRVPVSLNGTVYAGDFEVGFEGVLRLNLSPYGVDDAGCVPFNETVKVCLEGWRRLSTNQTLRARWLALNLSDSEVFEQVWGYAPAKLEGAVIELIAGNTTVKTVAQPSKMMVVPFRAVYKYLGNGWFWVNGSDWVFYISMPPWKKIKVELNYTAWGGAWGRLAVVVRNDNLYFDVGAALGNTPTLTCVIDRGIIDLFYPWTFKSEDEINRLFIQTDYSKYFSCATWERRTAAGPSLRVEPGMKQGDLRFDGTGEAYIRITILEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S000</accession>
    <name>A1S000_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753045.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1383"/>
    <dbReference type="EnsemblBacteria" id="ABL78780">
        <property type="protein sequence ID" value="ABL78780"/>
        <property type="gene ID" value="Tpen_1383"/>
    </dbReference>
    <dbReference type="GeneID" id="4600371"/>
    <dbReference type="KEGG" id="tpe:Tpen_1383"/>
    <dbReference type="eggNOG" id="arCOG03911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406513_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="10804" checksum="74CFA889B8D06130" modified="2007-02-06" version="1">MSQVYACPMCGWWGWPWTAPWYPGLGFAGALSMLVTLLFWVLLIALFAAILYYLARRASEPHQESSVSLERIENELKEIKERLERIEEEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S023</accession>
    <name>A1S023_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753068.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1406"/>
    <dbReference type="EnsemblBacteria" id="ABL78803">
        <property type="protein sequence ID" value="ABL78803"/>
        <property type="gene ID" value="Tpen_1406"/>
    </dbReference>
    <dbReference type="GeneID" id="4601820"/>
    <dbReference type="KEGG" id="tpe:Tpen_1406"/>
    <dbReference type="eggNOG" id="arCOG09752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119855_0_0_2"/>
    <dbReference type="OMA" id="HIVALMM"/>
    <dbReference type="OrthoDB" id="131804at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="16376" checksum="E4FA2BC3346F2E31" modified="2007-02-06" version="1">MVNGAEVPPLNPVLQFSQTTRTRPTGVTILAVLNMLGGALLVLLGLIFVAVGPLLERSTPATMPGLFSLILGGLGALLIVMGAVSLIVGWGLWTGKGWAWWVTVIFEVLGLLSGLLSAAAGDPFSVVGLLVSAIVLWYMFKPHVKDFFGVKVGFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S038</accession>
    <name>A1S038_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1421"/>
    <dbReference type="EnsemblBacteria" id="ABL78818">
        <property type="protein sequence ID" value="ABL78818"/>
        <property type="gene ID" value="Tpen_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1421"/>
    <dbReference type="eggNOG" id="arCOG07685">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1197682_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="26092" checksum="09E44ED4EC1BF2C1" modified="2007-02-06" version="1">MKAVVAPTYAYVKSRAGEADPPVSVALGKAVEVATSKYNYYYRRARRPPLGYAQRCAVAVLKAELEKMGYRASREEVEEAARRIWRMLAAWSKSPYTRYLKPKTHVVIFLKEGFAGALYAQPDFKDEYTGHFYEVKSFDVEREPRRHVYYQAGVFSLLGPLSLVYFSEDGGYYVLREKAVPRDTGIIDDVVSFLEGRPEGSRVVDLEALKKEHPWVAYRKVNGDWVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S040</accession>
    <name>A1S040_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formylmethanofuran dehydrogenase, subunit E region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753085.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1423"/>
    <dbReference type="EnsemblBacteria" id="ABL78820">
        <property type="protein sequence ID" value="ABL78820"/>
        <property type="gene ID" value="Tpen_1423"/>
    </dbReference>
    <dbReference type="GeneID" id="4600719"/>
    <dbReference type="KEGG" id="tpe:Tpen_1423"/>
    <dbReference type="eggNOG" id="arCOG00762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087508_0_0_2"/>
    <dbReference type="OMA" id="HGHVCPY"/>
    <dbReference type="OrthoDB" id="90623at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026328">
        <property type="entry name" value="FmdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003814">
        <property type="entry name" value="FmdEsu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02663">
        <property type="entry name" value="FmdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006578">
        <property type="entry name" value="FwdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FmdE" evidence="5">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DksA C4-type" evidence="4">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="25362" checksum="B3C1A18E328D6023" modified="2007-02-06" version="1">MVSKELLEKAREFHGHVCPYLVLGLRASEIAFEKLGVRERPGVSETLGEELVAIVEANNCFADGVQVATGCTFGNNALIYLDTGKTALTLFRRGEKRGVRVYVVPEKVESLYPPRASELWRKVVVEGRGTREDAEELDKLFEELGLRMLELPESFFKVEEVSFEEEVERAPIFETVKCSKCGELVWKPRAVYVDGKPLCASCAGVPVPAVLGRGIVASFRIPFRVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S045</accession>
    <name>A1S045_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c biogenesis protein, transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1428"/>
    <dbReference type="EnsemblBacteria" id="ABL78825">
        <property type="protein sequence ID" value="ABL78825"/>
        <property type="gene ID" value="Tpen_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1428"/>
    <dbReference type="eggNOG" id="arCOG02407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560967_0_0_2"/>
    <dbReference type="OMA" id="GFLAVQC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="86"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="440" mass="45890" checksum="660654FC9C1E9D30" modified="2007-02-06" version="1">MGLTARWTPRPRASAPSGLHAFSAHRVRASAGLRETVIFHLDTRVYAMKTWKLSLNSPAKSRRLGWRALVAMVALSAVLSVALLYARSQRPAEPYLLASSSEVYSAVSSGGAVAIMFSSPTCPVCEKMEPYWAALASRGGVLAVRFYVVRLGEGTAEAFYKYGVTSTPTYILFLDGRVAARYVGEFPGPNVTQSMLSWVLASLVQPLPQAGAPQGNSCEAGSCPVEPRSQGSGLPLVAAVVSFFAGVLAAFSPCTLPLLIAHAAASARVGARASRMAGGCFAASASSILALGLLFALLSKALSVAHAVLTSFTAILLLLLGASGVAGYRVDLPAVLPGGRLGVYGRCGLFGFLSVQCNLPLVLGPFLAVVGTSMEDFSEALYLALGYSLGTSSVLALALSGSGKVASLFERALYREDLVNRLSGLLLIAAGTLLLFQPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S048</accession>
    <name>A1S048_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1431"/>
    <dbReference type="EnsemblBacteria" id="ABL78828">
        <property type="protein sequence ID" value="ABL78828"/>
        <property type="gene ID" value="Tpen_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1431"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032306_1_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="143"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="49543" checksum="12FC081255C3C64C" modified="2007-02-06" version="1">MTREDKEKYEFVLLPFEVPEGVEAIEVEYSYRAAGSGECEVDIGLFSPGDPSFPADPSVFRGWSGTNKKRFVVGRRYATPGYLPGDITPGTWHILLGLYKIPECGCEYEVRVELLGSERGEEARVPQPAGGGGGARGPGWFKGDLHVHSVHSDGDASVAELARIASGKGLDFVVLTDHNTVSHVAECLSTAGPARVFPGMEVTTYYGHMNLFGVRSWVDFRARSEGDARRVIEEAKRRGYFTSINHPKPDYPWLLGNEDRVDGLEVWQTVWEYFNYLSLRKYVELLERGRDVVAVGGSDAHRVAREEGIPRLGEPTTVVYMERLSEDEFLKSLRLGRVYVTENPSGPRLVYRARGGGAEASLETSRLLPRVESIEVFVEGGAGSVVLLLTPGGVVKLGFVDGDSSVVKASVEHSGDGFYALPLLASAEYPFDDPLSEDAVVRAIANPVLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S054</accession>
    <name>A1S054_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753099.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1437"/>
    <dbReference type="EnsemblBacteria" id="ABL78834">
        <property type="protein sequence ID" value="ABL78834"/>
        <property type="gene ID" value="Tpen_1437"/>
    </dbReference>
    <dbReference type="GeneID" id="4601367"/>
    <dbReference type="KEGG" id="tpe:Tpen_1437"/>
    <dbReference type="eggNOG" id="arCOG03877">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087511_0_0_2"/>
    <dbReference type="OMA" id="MYKEYIA"/>
    <dbReference type="OrthoDB" id="140408at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="181" mass="20477" checksum="A5174EE1A5AEC58C" modified="2007-02-06" version="1">MELLDLVSLLVTQAPLVATAIAILVVYIERRIAYVEKRLSGLESRLGGLESRLDEITRSVNSLVDFNEALLSIQVGKGLLAGTEYKALQTLLAVSRPQPKTKYYTKEVYERLGQLLSKDPDELTWDDVFELEKIHDLLIMEWRESRREELARYAGKLRVAIAMAKGFLLKRGVLPPPNKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S057</accession>
    <name>A1S057_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753102.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1440"/>
    <dbReference type="EnsemblBacteria" id="ABL78837">
        <property type="protein sequence ID" value="ABL78837"/>
        <property type="gene ID" value="Tpen_1440"/>
    </dbReference>
    <dbReference type="GeneID" id="4601370"/>
    <dbReference type="KEGG" id="tpe:Tpen_1440"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_3_0_2"/>
    <dbReference type="OrthoDB" id="13246at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="129"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="539" mass="59854" checksum="6053C71F3D79520D" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S067</accession>
    <name>A1S067_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753112.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1450"/>
    <dbReference type="EnsemblBacteria" id="ABL78847">
        <property type="protein sequence ID" value="ABL78847"/>
        <property type="gene ID" value="Tpen_1450"/>
    </dbReference>
    <dbReference type="GeneID" id="4601159"/>
    <dbReference type="KEGG" id="tpe:Tpen_1450"/>
    <dbReference type="eggNOG" id="arCOG01880">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381481_0_0_2"/>
    <dbReference type="OMA" id="VSTFGDC"/>
    <dbReference type="OrthoDB" id="76485at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="197" mass="20883" checksum="419CABB4932EADC5" modified="2007-02-06" version="1">MKQETLRELRRKSIHVIPGVLAIPVVVWLGNPIATAIAAFFFALYAVHEAVLRLGLRVEVPIASHTFRVMARREELEGGYFTGTVYFWFSTLLIVALMEPHRAAASVMVSSFGDAAAAVVGREVGGPRLPFNRRKTLAGSAAMFLAAFASCLVAGVPLFPSLVASIVSTLAEAATTSSTLDELTVPAASALTLGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S080</accession>
    <name>A1S080_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753125.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1463"/>
    <dbReference type="EnsemblBacteria" id="ABL78860">
        <property type="protein sequence ID" value="ABL78860"/>
        <property type="gene ID" value="Tpen_1463"/>
    </dbReference>
    <dbReference type="GeneID" id="4601581"/>
    <dbReference type="KEGG" id="tpe:Tpen_1463"/>
    <dbReference type="HOGENOM" id="CLU_499345_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="545" mass="58372" checksum="D4E9BE2614E4BC3E" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S088</accession>
    <name>A1S088_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1471"/>
    <dbReference type="EnsemblBacteria" id="ABL78868">
        <property type="protein sequence ID" value="ABL78868"/>
        <property type="gene ID" value="Tpen_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1471"/>
    <dbReference type="eggNOG" id="arCOG03216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076326_1_1_2"/>
    <dbReference type="OMA" id="TFTHEHE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007161">
        <property type="entry name" value="DUF364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025251">
        <property type="entry name" value="DUF4213"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04016">
        <property type="entry name" value="DUF364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13938">
        <property type="entry name" value="DUF4213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4213" evidence="2">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF364" evidence="1">
        <location>
            <begin position="109"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="258" mass="27255" checksum="0D71513E93E778D0" modified="2007-02-06" version="1">MYRGPALSTVGVVEEIYEYALSRAGSERVKRVVIGVHATLVELEDGRAGVAYTNREGPLSSVTPGRLRGMNVSDALGLLLSPRGLEVSVGLAAVNALLNAAGEGVVEADALEQVGVAPGDSVVLVGYFAPYVEALRGRVRRLAVLEFASVVVEGVEVYPWWAYAAVLRDADKLLITGSSIVNHTINYLLTAPTRAEKHLVGPSSPLAPEVFGRYGVKTINTAVVVDPESCATILMEGGGFSSCFREGCLRKVSARLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S089</accession>
    <name>A1S089_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Tpen_1472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753134.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1472"/>
    <dbReference type="EnsemblBacteria" id="ABL78869">
        <property type="protein sequence ID" value="ABL78869"/>
        <property type="gene ID" value="Tpen_1472"/>
    </dbReference>
    <dbReference type="GeneID" id="4601573"/>
    <dbReference type="KEGG" id="tpe:Tpen_1472"/>
    <dbReference type="eggNOG" id="arCOG03706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153003_0_0_2"/>
    <dbReference type="OMA" id="FAVYSRV"/>
    <dbReference type="OrthoDB" id="130579at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14678" checksum="49DF4AC7888B6DF1" modified="2007-02-06" version="1">MIYLDTSVIVSYVDEEDPNHGRAVELLGRLMEDRVASQLTLLELAAVYSRAGLPNPVSLAVYSLRVVGASLVDVDLNQVSRQALRYAQLLRLRTLDLLHVVAARMLGASAVASFDKEIAERAGAIREALGLEFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S094</accession>
    <name>A1S094_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Tpen_1477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753139.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1477"/>
    <dbReference type="EnsemblBacteria" id="ABL78874">
        <property type="protein sequence ID" value="ABL78874"/>
        <property type="gene ID" value="Tpen_1477"/>
    </dbReference>
    <dbReference type="GeneID" id="4601578"/>
    <dbReference type="KEGG" id="tpe:Tpen_1477"/>
    <dbReference type="eggNOG" id="arCOG02221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149092_0_0_2"/>
    <dbReference type="OMA" id="TANYKER"/>
    <dbReference type="OrthoDB" id="127094at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="154" mass="16988" checksum="9FD102420646EE8E" modified="2007-02-06" version="1">MSRKARVALDTSVIVEYIDARGDLHRQAELVFSALLSGRLEALIPHPVLAETYYVAARLYRALGAGDPEGTASRLVSWLYRLPSVSVPEGGVELAVEAGRVKARYGVALTDCYVLAVARVYACKALFKRPEGEMAKHLDELRREYGAVFLEDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A1</accession>
    <name>A1S0A1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ transporter protein, CorA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1484"/>
    <dbReference type="EnsemblBacteria" id="ABL78881">
        <property type="protein sequence ID" value="ABL78881"/>
        <property type="gene ID" value="Tpen_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1484"/>
    <dbReference type="eggNOG" id="arCOG02265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_2"/>
    <dbReference type="OMA" id="CCMPLTI"/>
    <dbReference type="OrthoDB" id="43588at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="273" mass="30325" checksum="F6930E2AFFEC8FF3" modified="2007-02-06" version="1">MEVDGRSVADALRELPVDLDVAELVARDAERTRVTAYKDALVVVLGYPGKGRFAALLRGDTVAVAAPRGLLARLREDFEKNSYGCRSSPDAFLALSLLRLIDEYYAYYDALEDEIDGLEDSVAEDPTRVDVARFRRVRGSLVEFRRDLYSLRAAASLLLGEGVYDLSEGAKRLVQEVYEDAVQLLDMVESQKERLADIRDLHLSALSLALNEVMKKLTAINVIALPLLVIAGIYGMNLEIPEARWPYAYPAVLTAMATLTAILAYALRKRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A9</accession>
    <name>A1S0A9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753154.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1492"/>
    <dbReference type="EnsemblBacteria" id="ABL78889">
        <property type="protein sequence ID" value="ABL78889"/>
        <property type="gene ID" value="Tpen_1492"/>
    </dbReference>
    <dbReference type="GeneID" id="4601401"/>
    <dbReference type="KEGG" id="tpe:Tpen_1492"/>
    <dbReference type="eggNOG" id="arCOG01573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115707_0_0_2"/>
    <dbReference type="OMA" id="FGWQIVK"/>
    <dbReference type="OrthoDB" id="108311at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="215" mass="22802" checksum="52B46C1E28AEA8B7" modified="2007-02-06" version="1">MVSDHVIEAYWKVLAVSSVATNVRKSLQKLALWIVTYVVVTATVFTAVPYFFPLAKPVIDAYATYISIGLSLFFGYMIIRAFADTVYWTLRAKYPHPTAAAVRSLFTILGIGALLAGIAGGTAGGAAGVALGGFIGMVVGFASQQVLGQALAGLFTLIVRPIRIGDRVNVAGEEGVVEDISTLFTVIRKSDGSLALIPNNMVIGSKIYVLQRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B4</accession>
    <name>A1S0B4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase U34, dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753159.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1497"/>
    <dbReference type="EnsemblBacteria" id="ABL78894">
        <property type="protein sequence ID" value="ABL78894"/>
        <property type="gene ID" value="Tpen_1497"/>
    </dbReference>
    <dbReference type="GeneID" id="4601406"/>
    <dbReference type="KEGG" id="tpe:Tpen_1497"/>
    <dbReference type="eggNOG" id="arCOG03602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046840_2_0_2"/>
    <dbReference type="OMA" id="AKAQGWW"/>
    <dbReference type="OrthoDB" id="5084at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="437" mass="49428" checksum="D818D8BF5561214E" modified="2007-02-06" version="1">MCDTLVALRGATRDGVTIFAKNSDREPNEAQVLEFVPRMRHTEERVRVTYVEVEQVDETYAVLISRPFWMWGAEMGVNEFGVAVGNEAVFTRGGYSKTGLTGMDLVRLALERSRTAREALKWITSLLEEYGQGGNCSYFRKMFYNNSFLVADPREAWVLETVGREWVAERVESVRSISNALTIGERWDSSSPGLEEAARRLGCRSPVNFRECFSDFLYTRVSKGRERHRYTQGELEKAVGKIDFFFVASLLRRHSREPYEPSRGSNADICMHAGGLTRPSQTAASMIALLYEEAPVAFVTGTSTPCISAYKPVFLSAGLPDLGPKPSHVFDGGASYWWKHELLSRKLLCGYSRYAGVVAREMERVERKYFEKAMEARTGYLKGLVGAEELRRITAEAFREAAEVEERLAAEVKASRCLNPLYALYWRRINREASLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C7</accession>
    <name>A1S0C7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1510"/>
    <dbReference type="EnsemblBacteria" id="ABL78907">
        <property type="protein sequence ID" value="ABL78907"/>
        <property type="gene ID" value="Tpen_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1510"/>
    <dbReference type="eggNOG" id="arCOG07038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021631_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14573" checksum="594AE8D28A9DAA3F" modified="2007-02-06" version="1">MLKYCFSAFLRARMLVPTLSGLVAVLTSAVLRLAKGKPSSEDEWSAFAAGIVLAFIDGFMIAYLVPFFPYFASKFLFHVYLYTLLASLTAVLYAMYKAVTDLRVYAAASIPWILVILLVAVAKATGSPTIFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D3</accession>
    <name>A1S0D3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753178.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1516"/>
    <dbReference type="EnsemblBacteria" id="ABL78913">
        <property type="protein sequence ID" value="ABL78913"/>
        <property type="gene ID" value="Tpen_1516"/>
    </dbReference>
    <dbReference type="GeneID" id="4601112"/>
    <dbReference type="KEGG" id="tpe:Tpen_1516"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="QFGVADY"/>
    <dbReference type="OrthoDB" id="67758at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="169"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="328" mass="34913" checksum="A1BBF8740DAF4E0A" modified="2007-02-06" version="1">MKAALLYGPGDLRVEDVPLPEKPEGWALVKTLAVGICGTDKAFYKGTYPLFKKPLIPGHEVSGVVVEGPEELVGRLVVSEINFPCWRCEYCRSGLYTHCPYKKTLGIDFDGGLAEYFVAPATALHAAEGLDPVVATEVEPLAALLNALRLKPPAPGDSVAVVGTGNLAVMLVQVLKDAGFRPVVVSRAGSSKAEILRSLDVEVVTAEQASRLGGESGDGVGFDVVFEVSGDPSALNLAVDLVKPRGTVHLKSTPGNPGSVNLTKAVVKEVAVIGSRCGTFREFREAIRLLREGRVRPVITSVYGGLEKAREAFERSFRPGEVKVVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E6</accession>
    <name>A1S0E6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753191.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1530"/>
    <dbReference type="EnsemblBacteria" id="ABL78926">
        <property type="protein sequence ID" value="ABL78926"/>
        <property type="gene ID" value="Tpen_1530"/>
    </dbReference>
    <dbReference type="GeneID" id="4600372"/>
    <dbReference type="KEGG" id="tpe:Tpen_1530"/>
    <dbReference type="eggNOG" id="arCOG04236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_2"/>
    <dbReference type="OMA" id="VHIMEAG"/>
    <dbReference type="OrthoDB" id="44302at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="25721" checksum="BEE4D47855364AB2" modified="2007-02-06" version="1">MTLLEALDLHVEVGGAEVLRGVSLGVGEAEVHFLMGPNAAGKTTLLSALAGLPRVRVVSGRVLLDGEDVTGLPVVERARRGVALAYQIPPELVGVPLRSLAKLVSGRFGTGAYVEELSRRLRLEHLMGRDSFRGFSGGERKRAELFLVALMRPRLALLDEPDSGVDLDSLWLIADALSFVSEEFGTAMIVVTHTRALIEKVGGTAAHVLCDGRIVYSGAPGSVAGLVEERGFKGLCGEADGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F2</accession>
    <name>A1S0F2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753197.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1536"/>
    <dbReference type="EnsemblBacteria" id="ABL78932">
        <property type="protein sequence ID" value="ABL78932"/>
        <property type="gene ID" value="Tpen_1536"/>
    </dbReference>
    <dbReference type="GeneID" id="4600378"/>
    <dbReference type="KEGG" id="tpe:Tpen_1536"/>
    <dbReference type="eggNOG" id="arCOG06126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091659_0_0_2"/>
    <dbReference type="OMA" id="IYCVGAM"/>
    <dbReference type="OrthoDB" id="100381at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="222" mass="22514" checksum="800D26093B7FE4B2" modified="2007-02-06" version="1">MLGTLVNTLTVLAGSLVGLLLRKSVNAERVAFVADVLGLFTVAIGVQMALQARKPVAMIVSLLLGSLVGEALGVEGALQRLSERVSRTRSQGVVDGMLTAFLTFCVGPMTVVGSIRDGLGDPSILLAKSVMDGVASVAYAAAMGVGVVFSSVLVLAFQGSLALLGALTGALLPEASVNELTAAGGVLLIGVGINLLKLKRIRVGNMLPALLLAPILALTGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I2</accession>
    <name>A1S0I2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="7">BPG-independent PGAM</shortName>
            <shortName evidence="7">Phosphoglyceromutase</shortName>
            <shortName evidence="7">aPGAM</shortName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apgM</name>
        <name evidence="10" type="ordered locus">Tpen_1567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753227.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1567"/>
    <dbReference type="EnsemblBacteria" id="ABL78962">
        <property type="protein sequence ID" value="ABL78962"/>
        <property type="gene ID" value="Tpen_1567"/>
    </dbReference>
    <dbReference type="GeneID" id="4601525"/>
    <dbReference type="KEGG" id="tpe:Tpen_1567"/>
    <dbReference type="eggNOG" id="arCOG01696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_2"/>
    <dbReference type="OMA" id="IAFRCNF"/>
    <dbReference type="OrthoDB" id="17268at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01402_A">
        <property type="entry name" value="ApgM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="9">
        <location>
            <begin position="13"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="429" mass="46833" checksum="578A53078DBF7C5C" modified="2007-02-06" version="1">MSEYWSPKPLYRSVVLILDGLGDRPVPELGGRTPLQVARKPTLDSLAAEGVTGIMDVIEPGVRPGTDTGHMALFGYDPYRFYPGRGPLEAAGIGVELKPGDVALRANFATVREEGGRLIVVDRRAGRIRGEDAEALTRYLNERIGSVDDVRVSFHHATAHRLVVVLRGDSLSPRVSDSDPGTAREGEPVREVKPLTNDPESERTARILWKLLLRAHEELERCPVNEERVKRGLLPANAVLTRGAGMVPYGIVPFREQFGATAYLVAEEATVLGVARILGIEGEIPGGSTADLDTDLDAIFNRALDAYRRGYEFVFIHVKGTDIAGHDAKPLEKARFIERVDEAFAGFLSRIDRGKTIVAVTADHSTPCTVRDHSGDPVPLLINGPGVRRDDVTSFDEISCARGGLGRIRGVNLVRILLDLMNKPIMFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J3</accession>
    <name>A1S0J3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1578"/>
    <dbReference type="EnsemblBacteria" id="ABL78973">
        <property type="protein sequence ID" value="ABL78973"/>
        <property type="gene ID" value="Tpen_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1578"/>
    <dbReference type="eggNOG" id="arCOG01273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_0_2"/>
    <dbReference type="OMA" id="MIFMRDG"/>
    <dbReference type="OrthoDB" id="49280at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="344" mass="36558" checksum="AE62F071F75F21F0" modified="2007-02-06" version="1">MIDVVGFLISWLTLLGIYAILALTLNFESGTSGVTNFGKVFFYGLGAYVGATLTVYLFLLLNGVDVSKTPPYDVSGIVLLGELAGKNPALNLGLLALSLATAFLVAGVIGYLLSYPIIRVGPAFVGFTLLSTGELFRIFLQHYEPVGGSRGLMSIPGPFSWVPQPRLREVLFLALVLAVLAATYLVMDRLTNSPLGRTLRAVRDDEVAALCMGKHVPKLKATVLFIGSGFSGVAGVLLAYYLTSVNPDMFVPAVTFNVWAMIILGGMGNLRGALLGASIFTFIDRALSFVTPQLGVTVISPDYVRGFAVGLVMVLVLLYRPQGLLPEGRVETVAWEELGGGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M4</accession>
    <name>A1S0M4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Tpen_1609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1609"/>
    <dbReference type="EnsemblBacteria" id="ABL79004">
        <property type="protein sequence ID" value="ABL79004"/>
        <property type="gene ID" value="Tpen_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1609"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902050_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="131" mass="14472" checksum="7C5FD372FD92A9FB" modified="2007-02-06" version="1">MPVVDTEFLFALSPGDPRHGRALRLLSMKGLKVPDTALLEFQVVLRARGRKPGEIAAAMNALKHVFKSYRVREVSTIGTELFVRQAELEEKYGLSYFDSMIAASALAVDGVIVSDDRAFDRVPGLRRIPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P8</accession>
    <name>A1S0P8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SPP-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753293.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1633"/>
    <dbReference type="EnsemblBacteria" id="ABL79028">
        <property type="protein sequence ID" value="ABL79028"/>
        <property type="gene ID" value="Tpen_1633"/>
    </dbReference>
    <dbReference type="GeneID" id="4600912"/>
    <dbReference type="KEGG" id="tpe:Tpen_1633"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="OMA" id="DTGYAYH"/>
    <dbReference type="OrthoDB" id="58398at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="25836" checksum="2183340A1B4A0867" modified="2007-02-06" version="1">MARVAVFVDVDWTLTDRERRISSRVVEALERLQREGYFVVLASATAYPIVYGLSRYLPTSGVAVGENGGVVGDGRRLEILGRIDKELVLRVARERLSCCLEDSWQNLFRFVDVTFALRKGVDPGYAVGEARHVFGAMGLEVKYSGVALHVHPPGVNKGVGLRKALEMLGGGFDYVVAVGDSEVDVDMFRVADFSACPAHAPEEVKKEASYVAKAPYSDGFLEIVDVVLRGAGKPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q5</accession>
    <name>A1S0Q5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753300.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1640"/>
    <dbReference type="EnsemblBacteria" id="ABL79035">
        <property type="protein sequence ID" value="ABL79035"/>
        <property type="gene ID" value="Tpen_1640"/>
    </dbReference>
    <dbReference type="GeneID" id="4600919"/>
    <dbReference type="KEGG" id="tpe:Tpen_1640"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OMA" id="QVPYAGI"/>
    <dbReference type="OrthoDB" id="15038at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="503" mass="53461" checksum="771029303C91E519" modified="2007-02-06" version="1">MSKLRRELGLLELVGISVGGIIGSGIFMMPSLTLSTAGLSALLAWILAGVAMTVVALVFAELGSAFGDTGGPYVYARAAFGRTVGFLVGWGYYVSCVLTVSAVTAAFVSYLGFFVPGLVEGQRLTPVGVLAGLAFLWFLTLLNYVGVKYGGLYASATTLLKVFALAIFAAAGLAYPEPSRFNVLEGLDAVSLGLAVSLAVWPYMGFESVTIPVEEVKKPQRDVPLSIILSMGIVTAVYVLIVLSFLSLLDWKSLGLAQGDWGSLANLSSPLSDVARSRGLLAVAVAVMLGAVFSTGGASGVWLLDSGRFPYAFSQAGDLPKVLGKVHDRYGTPHVGLLLSSIVASAVLVLLPLFPAIALLGVMTSIVPYAVSSLGLAVLRGRGDYRPAFRNPFGKLVAYVSFVFSTLVAYWSCWPWTLVGALLTLAVVPVFARVAGVGLRREDLWYFAYLSGLSVVSLLGDPYFEYYNFLPVHPLGVFKTPVDIAVLVVFASAFFFYVARTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V4</accession>
    <name>A1S0V4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753349.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1689"/>
    <dbReference type="EnsemblBacteria" id="ABL79084">
        <property type="protein sequence ID" value="ABL79084"/>
        <property type="gene ID" value="Tpen_1689"/>
    </dbReference>
    <dbReference type="GeneID" id="4600577"/>
    <dbReference type="KEGG" id="tpe:Tpen_1689"/>
    <dbReference type="eggNOG" id="arCOG01205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159724_1_0_2"/>
    <dbReference type="OMA" id="AGLPDYH"/>
    <dbReference type="OrthoDB" id="122104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="122" mass="13563" checksum="84381CC627B340C9" modified="2007-02-06" version="1">MSSWVKRHFEHLRKWREYAEAIAKAAMDVVPGARVYVIGGVAEDRVTALSDIDILVVVPGGARKGLYADVLERAIDAYGLPWDAPVELHIVSENEAKEYLRRARRAVHVTPGGLEVDNRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y2</accession>
    <name>A1S0Y2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1717"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79112">
        <property type="protein sequence ID" value="ABL79112"/>
        <property type="gene ID" value="Tpen_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1717"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_2"/>
    <dbReference type="OMA" id="APVPWFP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="239"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="426" mass="48143" checksum="C8F800F5B45220CF" modified="2007-02-06" version="1">MRLRGWLYTRATRRRRMMEAGSSDISVAIVSSVVGKSPREVTYSFVFDEAYRLVQRGVNVHVVRAAVEESSSSYGINFHGIRRRVDAEAFVELLKNLPLYSPFALLRNPLMLYWENLYALNISNVVENLRIDLIHAHFAYPEGFSGLIAKRRTKKPLVVTLHGYDILVEPSVKYGIRLSKRYDALVREVLVNADAVIVASRAVFEEAVKLRGRKSGTYLVHNGVDIKRFNPNLNGSLIRKRLGIENKFVVFSARHHRPVYGLEYLIKAAALVVKLRSDVVFVIGGEGPLRTYHEKLVEMLNLENNVIFTGRIPRDEMPHYYAASDAVVVPSLQEAWSLVVTEAMASGKPVVGTRVGGIVDQIIDGYNGFLVPPRDPKAIAEKILWLIDNPDEAKRMGMNGRRLAEEKFDIEKRIEKIIGIYKELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S106</accession>
    <name>A1S106_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753401.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1741"/>
    <dbReference type="EnsemblBacteria" id="ABL79136">
        <property type="protein sequence ID" value="ABL79136"/>
        <property type="gene ID" value="Tpen_1741"/>
    </dbReference>
    <dbReference type="GeneID" id="4601766"/>
    <dbReference type="KEGG" id="tpe:Tpen_1741"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136109_0_0_2"/>
    <dbReference type="OMA" id="AREVKPW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="242" mass="25286" checksum="FD67A55EABD5600C" modified="2007-02-06" version="1">MKSRAFSFFQAFLEAVSGVAEELSSAGKPPASPWALVLVGLAADVEASYASGPATPAMAIALGAVLAATSRKLRGWLTVTLVSAFFAGLVALPALLRGDPGAPLFVLRAVAASSAFTGVLASLGWLWLLRGLEELRLPRGLVWELGLTLRAIPVFARDASRMLAAREARLLASSRASWSVVSSVAGDLLLAGVRRARALQMALEARSFGEPLAPRRRLDPRPADAALIAWALLMTAVFAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S113</accession>
    <name>A1S113_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753408.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1748"/>
    <dbReference type="EnsemblBacteria" id="ABL79143">
        <property type="protein sequence ID" value="ABL79143"/>
        <property type="gene ID" value="Tpen_1748"/>
    </dbReference>
    <dbReference type="GeneID" id="4601773"/>
    <dbReference type="KEGG" id="tpe:Tpen_1748"/>
    <dbReference type="eggNOG" id="arCOG02745">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961788_0_0_2"/>
    <dbReference type="OMA" id="TTHAMNT"/>
    <dbReference type="OrthoDB" id="95312at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="289" mass="31824" checksum="35E1B29C4ABDB635" modified="2007-02-06" version="1">MDDHCRAARSALRIAERDVANYATGTSPVSSMGLGLEYVDFREYQPFDDARHIDWRATARSPGPDGGYRPIVKVYRAERKTRVALAVDLSASMLYQSKPKTLVYALAVIAAVADTLEDTFTLVLSTGRGFEVYGKVKPRDLPHIIASRICASTAPGKATLGEIAARLLALPRAPVLLVTDYAHSLEDFERSSKTLAASRGAAYLLVYDWWEVHPPPDALATLVDPETGSRVHGRLREVYAGIARHVALARSRLTSGGSAFMDTCWQKAREDRARLSLLYLKARSLKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S123</accession>
    <name>A1S123_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753418.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1758"/>
    <dbReference type="EnsemblBacteria" id="ABL79153">
        <property type="protein sequence ID" value="ABL79153"/>
        <property type="gene ID" value="Tpen_1758"/>
    </dbReference>
    <dbReference type="GeneID" id="4601956"/>
    <dbReference type="KEGG" id="tpe:Tpen_1758"/>
    <dbReference type="eggNOG" id="arCOG07488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406487_0_0_2"/>
    <dbReference type="OMA" id="ICTCLNA"/>
    <dbReference type="OrthoDB" id="142065at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10212" checksum="DBE652FC9857A54A" modified="2007-02-06" version="1">MGFPEAYAVVRLSPEAPRSIKNKVSKTLLGTTVTVKGKRYRGRGLLEKHGGLALCPGTYLVPLTELEAFLGELDSRGLRNYVVVDNLCIYACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S158</accession>
    <name>A1S158_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type tungstate transport system permease component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753453.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1793"/>
    <dbReference type="EnsemblBacteria" id="ABL79188">
        <property type="protein sequence ID" value="ABL79188"/>
        <property type="gene ID" value="Tpen_1793"/>
    </dbReference>
    <dbReference type="GeneID" id="4601916"/>
    <dbReference type="KEGG" id="tpe:Tpen_1793"/>
    <dbReference type="eggNOG" id="arCOG00229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061511_0_0_2"/>
    <dbReference type="OMA" id="LADRGTW"/>
    <dbReference type="OrthoDB" id="49385at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="39"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="318" mass="34925" checksum="492FBFA036C6B507" modified="2007-02-06" version="1">MKKTLVILLAVVAVALIAAAILVPPMLRQAAPGVQAQQPGKRVTLRIATTTSMDATGLLDAVKKRFEAKYPWINVTWVAVGTGQAIEIAKRGDADLVIVHNRDLENQFIAQGYGVHGITFAYNDFVLLGPPEDPAGVSGAGSAVEAFKKIYEAGVAGKAVFVSRGDKSGTHLRELSIWKQAGLKPQGQAWYKETGQGMSQTLMVADQLNAYTLSDRSTYLAFKDKIHLVILHQGDPLYLNLYRAIPVNPEKFPHVHYNESLLFVKFLVSPEGQYLIGTYQRGGAKLFNVCFGNLTKLGIYDPYEEEQVKFYKSLLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S182</accession>
    <name>A1S182_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1817"/>
    <dbReference type="EnsemblBacteria" id="ABL79212">
        <property type="protein sequence ID" value="ABL79212"/>
        <property type="gene ID" value="Tpen_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1817"/>
    <dbReference type="eggNOG" id="arCOG00706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="SYDYEPI"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="595" mass="66178" checksum="49C467C9DBB3ABA9" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B3</accession>
    <name>A1S1B3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1848"/>
    <dbReference type="EnsemblBacteria" id="ABL79243">
        <property type="protein sequence ID" value="ABL79243"/>
        <property type="gene ID" value="Tpen_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1848"/>
    <dbReference type="HOGENOM" id="CLU_1912445_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="15342" checksum="5127413A7E1467FE" modified="2007-02-06" version="1">MYGSTVSMEEYRRLRQYLLRKPTLGGCRVERVPGGYRVVCRRGNAVVSEEGAVFLFEDNRMAFYKGDVSVEGRDLRYPARPFSEALASIGFQEEAESPEELYGMAESVYTAWEEDIEEVKRRLRERYGEVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B5</accession>
    <name>A1S1B5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1850"/>
    <dbReference type="EnsemblBacteria" id="ABL79245">
        <property type="protein sequence ID" value="ABL79245"/>
        <property type="gene ID" value="Tpen_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1850"/>
    <dbReference type="HOGENOM" id="CLU_2067940_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="13536" checksum="6F97EC9B2160EBEC" modified="2007-02-06" version="1">MHRLTEEQINRVNATRKLLVVDSSKLPRGLLRYLTEKWRGDASQLLANAASFLPCRCRDCICTDEPRNNPGGDVVIVAGFLEWQLFLQVTEKYGVCFETVEQALTFAWEVMPSSFRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C6</accession>
    <name>A1S1C6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1861"/>
    <dbReference type="EnsemblBacteria" id="ABL79256">
        <property type="protein sequence ID" value="ABL79256"/>
        <property type="gene ID" value="Tpen_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1861"/>
    <dbReference type="HOGENOM" id="CLU_2713054_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="72" mass="7945" checksum="E197E80936226B76" modified="2007-02-06" version="1">MGEEVPRCFCGEVAVIRVGDVLLCKNHWRKVLGALAKIGDSRGEATLEDVKVEGGELVLRVSGRIIKVREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW34</accession>
    <name>A1RW34_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751679.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0004"/>
    <dbReference type="TCDB" id="2.A.1.66.1">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77414">
        <property type="protein sequence ID" value="ABL77414"/>
        <property type="gene ID" value="Tpen_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="4601889"/>
    <dbReference type="KEGG" id="tpe:Tpen_0004"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_2"/>
    <dbReference type="OMA" id="PSSFWIF"/>
    <dbReference type="OrthoDB" id="64309at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="428" mass="46528" checksum="CC22315DA73250E9" modified="2007-02-06" version="1">MPEGRPRVKVIVASLALFVLFYFMGYYMLNPILRTLHAEGLIPGKSEVEWRFNAGLIATLLQGTGLVLSFVWGVLADKVGRRPVIFTLGVIMGLGLLLVSQARSYAELLAYFIAFGVGYVGVGPAIYAFISDALPSESRGRGYASYYVSSVLAMILGLIVAGVLLPWRTAYMLAGLLTLVFSVLLFYSSRGIFIGYSEKGAREARRYSLRESLPSLRKKSVLLVLLMIIPWTIPWGMLSIWSIDYISTKWGVSTGTASLIIAAATASIALGHIVGGTLSDRLAGKGDYTGRTKVSLLGVVVGYVSMMLMVTYPYPYGSTNFKDLLVPSALAVGGMMFTTFAYPNINTVLSEVVVPEHRGTVFAVYSVLNNLGWTLGPTVYTLLLKAFSGVYADQVSAMTAAASTIVSLWLIPALCWLLLHRVYPKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW54</accession>
    <name>A1RW54_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751699.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0024"/>
    <dbReference type="EnsemblBacteria" id="ABL77434">
        <property type="protein sequence ID" value="ABL77434"/>
        <property type="gene ID" value="Tpen_0024"/>
    </dbReference>
    <dbReference type="GeneID" id="4601317"/>
    <dbReference type="KEGG" id="tpe:Tpen_0024"/>
    <dbReference type="eggNOG" id="arCOG09426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500355_0_0_2"/>
    <dbReference type="OMA" id="WGYIRTE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="179" mass="19293" checksum="2FBC5A3E870E570D" modified="2007-02-06" version="1">MDARRIAAVAVFTSTAVVFRVAKNLVTTVQFVNIPLAMAFVSSAILGYKEGFLVGFLSYVLSDMLIGPGFWTLVNPFLAGAFSAVFGFSYRRGLEKTYLFVSAFLSCFLFDVTTSVLFYMIFGLKPLDALVFGLLGLFVPVVGGFLVGVGPLTEFSTSALAVALLEALERRLGKNINIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW66</accession>
    <name>A1RW66_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751711.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0036"/>
    <dbReference type="EnsemblBacteria" id="ABL77446">
        <property type="protein sequence ID" value="ABL77446"/>
        <property type="gene ID" value="Tpen_0036"/>
    </dbReference>
    <dbReference type="GeneID" id="4601382"/>
    <dbReference type="KEGG" id="tpe:Tpen_0036"/>
    <dbReference type="eggNOG" id="arCOG15063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170815_0_0_2"/>
    <dbReference type="OrthoDB" id="142927at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="94" mass="10747" checksum="E1B97188BBF884BC" modified="2007-02-06" version="1">MAEGGKTCEKSYYYYRRVAEAVLREADIAELKDLALELVIAEVKAKIVMCGGGEEERRDAESLLEDIEKAKKLLYKAYVLMSTKGRSRKVVRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW67</accession>
    <name>A1RW67_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751712.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0037"/>
    <dbReference type="EnsemblBacteria" id="ABL77447">
        <property type="protein sequence ID" value="ABL77447"/>
        <property type="gene ID" value="Tpen_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="4601273"/>
    <dbReference type="KEGG" id="tpe:Tpen_0037"/>
    <dbReference type="eggNOG" id="arCOG14924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151714_0_0_2"/>
    <dbReference type="OrthoDB" id="127009at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="141" mass="15559" checksum="7BD36D0E49F72A60" modified="2007-02-06" version="1">MDLTGNIHRLLLEASRSLKSGVIDPQEFHKLGMVLLSTALLTEDNYFFVLSNTMYTLADALSSFLKVSSMPLSMEYRGKTEALIEEVKSELSHALQEIGEAISSGDKCRALLASSSMLRVSYRVNMLAETLKNVVVVGNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW70</accession>
    <name>A1RW70_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-inhibited division protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0040"/>
    <dbReference type="EnsemblBacteria" id="ABL77450">
        <property type="protein sequence ID" value="ABL77450"/>
        <property type="gene ID" value="Tpen_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0040"/>
    <dbReference type="eggNOG" id="arCOG01296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_2"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="340" mass="37005" checksum="D6ABAB74682CF347" modified="2007-02-06" version="1">MAGTHMKKYDVVIVGAGIAGLTAALYAARQKLSTLVVSADLGGQLLLTTEIQNFPGFMSIGGLELIRRVEEQAKTYGAEIVFDEVVGVEEREGVFVVKTASGAEYASDALILAFGKSPREMGVPGEREFKGRGVSYCVICDAPLYRGRRVALVGWGAHNYENIILLRDYASKVYWVFPGEKPIEEDELLREALSKGNVELVPFSEPAEVKGDKRVQALVVRDKRTSELRTLEVDGVFVEIGYVTKTGFLRGFVELNEKGEIVVDKACRTSRPGVFAAGDVTEMPHKQAVIAAAMGACAALSAYAYVMEKRGRKVVSTADWRHVEIPGKKKEGGGLAIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW97</accession>
    <name>A1RW97_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0067"/>
    <dbReference type="EnsemblBacteria" id="ABL77477">
        <property type="protein sequence ID" value="ABL77477"/>
        <property type="gene ID" value="Tpen_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0067"/>
    <dbReference type="eggNOG" id="arCOG00188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="YCDRIVI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="273"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="305"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="528" mass="57677" checksum="448B4FDD31B076C0" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW98</accession>
    <name>A1RW98_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751743.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0068"/>
    <dbReference type="EnsemblBacteria" id="ABL77478">
        <property type="protein sequence ID" value="ABL77478"/>
        <property type="gene ID" value="Tpen_0068"/>
    </dbReference>
    <dbReference type="GeneID" id="4601056"/>
    <dbReference type="KEGG" id="tpe:Tpen_0068"/>
    <dbReference type="eggNOG" id="arCOG07486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089225_1_0_2"/>
    <dbReference type="OMA" id="GVIFWAW"/>
    <dbReference type="OrthoDB" id="94974at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09819">
        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="200" mass="21698" checksum="4A71ACB373A4194E" modified="2007-02-06" version="1">MREEKLRVEELVLTAVLSAIIGAVFLVWSNVVWGASKLVLGLTLTPIIYGMWFIGATVPAYIVRKPLVALLGEFLAAVLELFYGSQFASTVLLYGFMQGLMSELVFFATRYKRWDWATMALAGAAPALWAAPADTVLYGITNPLSPGQRVVFWSLYFVSGALIAGVLVKALIDYVAKSSSLLDYFAVGKSVKKIGGSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD5</accession>
    <name>A1RWD5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751780.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0105"/>
    <dbReference type="EnsemblBacteria" id="ABL77515">
        <property type="protein sequence ID" value="ABL77515"/>
        <property type="gene ID" value="Tpen_0105"/>
    </dbReference>
    <dbReference type="GeneID" id="4600656"/>
    <dbReference type="KEGG" id="tpe:Tpen_0105"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_2"/>
    <dbReference type="OMA" id="WLTGVCT"/>
    <dbReference type="OrthoDB" id="79386at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="188" mass="21558" checksum="251D0F59D5E2A354" modified="2007-02-06" version="1">MPKYAVLVIDMLEEFVRGRLRAENAEKIVKPIKRLIDFAHETGIPVIHAVDQHYPDVDFEFRLWGAHAVRGAAESKIVEELAPSEKDFVVPKRRYDAFMFTDLDMLLRELGVTTLIVTGIHTHICVQQTVLGAFYRGYSVIVPLECVAAFNDTWHKIGLDYMKNYANATLMNLDELLEKLSREVHTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH4</accession>
    <name>A1RWH4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751819.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0144"/>
    <dbReference type="EnsemblBacteria" id="ABL77554">
        <property type="protein sequence ID" value="ABL77554"/>
        <property type="gene ID" value="Tpen_0144"/>
    </dbReference>
    <dbReference type="GeneID" id="4600636"/>
    <dbReference type="KEGG" id="tpe:Tpen_0144"/>
    <dbReference type="HOGENOM" id="CLU_125814_0_0_2"/>
    <dbReference type="OrthoDB" id="139221at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="185" mass="20470" checksum="77D0F14CAD0B4D00" modified="2007-02-06" version="1">MPRGSGKLRRSLFLLAVGFSALLAGFLASLYASYYVSPRERIELRLELPRNSFVEATLGAGVAERIYYVASIEGDRNVELVATFYDVNNESIGGFTLKDARYNSSGWVVLQGQPYRVTLESTCSLCRSNVTLILLYSRFSRTEVDILSTLGALLSITGMASLSAGLYQYLFAKYLSRTEQSAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI8</accession>
    <name>A1RWI8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751833.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0158"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77568">
        <property type="protein sequence ID" value="ABL77568"/>
        <property type="gene ID" value="Tpen_0158"/>
    </dbReference>
    <dbReference type="GeneID" id="4601267"/>
    <dbReference type="KEGG" id="tpe:Tpen_0158"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779883_0_0_2"/>
    <dbReference type="OMA" id="KWRALND"/>
    <dbReference type="OrthoDB" id="76206at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="386" mass="43846" checksum="54602F81ACF74D50" modified="2007-02-06" version="1">MSSRAIAEVVLEGKASQGRKVSVIIPSYRGSERLVRLVKRVASLPYEDKEVVVVVDEPLREVAEELRRIGGVKLILRPKRGGKVSALNEALRESSGEVVIFLDDDVYVEDDRFIEKVLKAMEGYDIADIKKVIVDTGGILSKLVYIEYASYNFASKLMARAARRTVAVNGAAFAVRRKALDEIGYFRPSISEDFDIALRSFKAKHNFTYIENTYVLNYPPSDFRKWFKQRKRWAIGLAAWLEENFADALKTLLRMPHAVIPGLLLALPSLSSALITFVLSNHVYEKTAYLFMLTLSSLVAQALPFASILLLNIQLIYLVKAGAILTAFFVFLFWQFAASRAVKMKSYLYLYPVYFFVYQPLWLTILLAGFIRVIVLRRKSVEDWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ4</accession>
    <name>A1RWJ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase associated with various cellular activities, AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751839.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0164"/>
    <dbReference type="EnsemblBacteria" id="ABL77574">
        <property type="protein sequence ID" value="ABL77574"/>
        <property type="gene ID" value="Tpen_0164"/>
    </dbReference>
    <dbReference type="GeneID" id="4601419"/>
    <dbReference type="KEGG" id="tpe:Tpen_0164"/>
    <dbReference type="eggNOG" id="arCOG00434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_2"/>
    <dbReference type="OMA" id="YPIPEPF"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="35902" checksum="25FF5E0E4F31684B" modified="2007-02-06" version="1">MDETIKATFERVFSEVEKAVVGKRRVVERLLVALLSGGHVLIEDFPGMAKTLLASSFAKALDLEFKRVQFTPDLLPSDITGSHVYDMHSSTFRFRRGPIFTNILLADEINRAPPKTQSALLEAMQERQVTVDGVTFALEEPFMVIATLNPIEFEGTYPLPEAQMDRFMLKVRMGYPSKEEEILILRRRLQRGTDKPSIEKVLSKSDVLSMIRKVEEVYVDDAVLSYIAEICRATRSVRDVEVGVSPRGTEALMKASRALAFIRGRDFVLPDDVKEVAVEVLAHRIVLRTESLVRGVSPEDIVRRVLDEVEVPRSVGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL6</accession>
    <name>A1RWL6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase, chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751861.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0186"/>
    <dbReference type="EnsemblBacteria" id="ABL77596">
        <property type="protein sequence ID" value="ABL77596"/>
        <property type="gene ID" value="Tpen_0186"/>
    </dbReference>
    <dbReference type="GeneID" id="4600799"/>
    <dbReference type="KEGG" id="tpe:Tpen_0186"/>
    <dbReference type="eggNOG" id="arCOG03626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088957_2_0_2"/>
    <dbReference type="OMA" id="IFFDLLM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="PTHR38601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="212" mass="23173" checksum="10670326D39FA4E2" modified="2007-02-06" version="1">MLGLEKSIGACAALMVLTASYINEERNLRRATYAYCVQTLLLASIFFMLSTVEWYFALWGLTAILTKAVLVPYFILRTTKRVDAVVEEEPYLGGWASHILLGALIAIGFAIGTRIVSGWESVPLSVSVALFLIGLHLMVTRRDALKQILGICHFENGSHLTLAVMAPGLPETVEVGVLTDAVLLVLVCCLLAEEMKKVVGTLDTGRLSLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ4</accession>
    <name>A1RWQ4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="8" type="ordered locus">Tpen_0224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0224"/>
    <dbReference type="EnsemblBacteria" id="ABL77634">
        <property type="protein sequence ID" value="ABL77634"/>
        <property type="gene ID" value="Tpen_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0224"/>
    <dbReference type="eggNOG" id="arCOG04372">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="168" mass="17978" checksum="B618CF9B7D271829" modified="2007-02-06" version="1">MSQNLKTFTFLVEGGKATAGPPIGPALGPLGLNVMQVVKRINELTADYAGMRVPVKVTVDVEKKTFEVEVGTPTTAALIIKELKVEKGAHQPSRENVGNLTLQQVIKIAKIKKKDMGASTLKAAVKTVAGTAQSMGVTIEGKPPKVFIEEVEKGLYDEEIRKHEGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ6</accession>
    <name>A1RWQ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751901.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0226"/>
    <dbReference type="EnsemblBacteria" id="ABL77636">
        <property type="protein sequence ID" value="ABL77636"/>
        <property type="gene ID" value="Tpen_0226"/>
    </dbReference>
    <dbReference type="GeneID" id="4601216"/>
    <dbReference type="KEGG" id="tpe:Tpen_0226"/>
    <dbReference type="eggNOG" id="arCOG01067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_8_1_2"/>
    <dbReference type="OMA" id="ISDHHIR"/>
    <dbReference type="OrthoDB" id="58933at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="391" mass="42643" checksum="F1B50A707B178683" modified="2007-02-06" version="1">MSGKTIVVVGGGFGGFYALKTLSGLGLTERNRVVLVDKSRRFVYLPSLPYLISGKKTVEDLTEPLEEIAKRLGAEFLLGEVTRVSLQEKTIELSNGEKLRYDYLVLAAGATTEYYGIPGAHQALPAWRLEDYERIVRELGKCGSGCRVCIAGGGLTGVEVAGEVAEKYEGKSEVVVVEKMQMLMPTLNSQRASKIIEEFLSSKGVRIIKGNGVSSVSEKNLNLEDGTSIQCDIVVWTVGVRPPDIRFDVDVPVKGRGWICVKPTLQVMSRDDVYAIGDINHFAVDSDYAMKMAEEAILQGKTAAKNIALQISGETPRYTHKPIFLASKPKSLVSVGYGRALMIWENKILFGRAPYISKMLIESIVMRDVKGKVGGGIATSLESKILRTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ9</accession>
    <name>A1RWQ9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl4</name>
        <name evidence="5" type="ordered locus">Tpen_0229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751904.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0229"/>
    <dbReference type="EnsemblBacteria" id="ABL77639">
        <property type="protein sequence ID" value="ABL77639"/>
        <property type="gene ID" value="Tpen_0229"/>
    </dbReference>
    <dbReference type="GeneID" id="4601219"/>
    <dbReference type="KEGG" id="tpe:Tpen_0229"/>
    <dbReference type="eggNOG" id="arCOG04071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="OrthoDB" id="65833at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_L4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_L4-archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="267" mass="29400" checksum="66A488E2E0F151DE" modified="2007-02-06" version="1">MSQEVAEVLEVPVYDLNGAAVERIKLPSFFKSPVRPDLIRRVYIALFTSRLQPKGTDPLAGLRTTAESLGVGHGIARVARIKGGLRAARVVQAVKGRRAHPPRVEKIIREEVNRKEKRKALLSALAAVASRDFVLKRGHVVPDIPLPVVVADDLESISKARDLRAFLEKLGLWKDVERAQTNTRVRAGKGKMRGRRYKKPKSLLIVVGEARGIELAARNMPGVDVVTYKELSVLHLAPGGNPGRLTVFTKSAVKGLEERLKGEVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT1</accession>
    <name>A1RWT1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0251"/>
    <dbReference type="EnsemblBacteria" id="ABL77661">
        <property type="protein sequence ID" value="ABL77661"/>
        <property type="gene ID" value="Tpen_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0251"/>
    <dbReference type="eggNOG" id="arCOG14768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168627_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="263" mass="28924" checksum="F7D8AC30C52F19ED" modified="2007-02-06" version="1">MYPTTLHQSGLFQATLTVDTLLVVFIAFASIGLSAGTLISLLYVLKVFAGRVKEPRGENFAKELESLALTLKELEKKVELLESGAGKPGSEDIRKLVEGLETLSAKVNTLETKLVVLEKRISREVPAPRPIAQPQVTAKPVAKEAVREVELKSLGDLPLYFPGLRFACIITSQGYPVEIYGQGSDEPARLLDILRLYNSQNVSLTRGGRKLEIFYLGEVRDLSVYGILEFSDAREVTEDVITAAKKSISKYFTEVLSKKGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT2</accession>
    <name>A1RWT2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751927.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0252"/>
    <dbReference type="EnsemblBacteria" id="ABL77662">
        <property type="protein sequence ID" value="ABL77662"/>
        <property type="gene ID" value="Tpen_0252"/>
    </dbReference>
    <dbReference type="GeneID" id="4601844"/>
    <dbReference type="KEGG" id="tpe:Tpen_0252"/>
    <dbReference type="eggNOG" id="arCOG02603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850732_0_0_2"/>
    <dbReference type="OrthoDB" id="110896at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="138" mass="14718" checksum="A4FEF50EBA171ED1" modified="2007-02-06" version="1">MSADKSDQVRGVLAKIIKETHDAIVSIVFAWRDGIPVAYVAPDQPQAEFLAVASAAALGSLDALGDIFNSKVKRVDVEFENGEHIVISSLDGSFIALSTTPRPNLGLIHLVLRKYEEDVVRTAGVGYAGPARLSQDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT3</accession>
    <name>A1RWT3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0253"/>
    <dbReference type="EnsemblBacteria" id="ABL77663">
        <property type="protein sequence ID" value="ABL77663"/>
        <property type="gene ID" value="Tpen_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0253"/>
    <dbReference type="eggNOG" id="arCOG00362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_2_0_2"/>
    <dbReference type="OMA" id="DRFDFMW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="182" mass="20306" checksum="63449210A0D9FB03" modified="2007-02-06" version="1">MQVQRGYLKILVSGPYASGKTTFVRTVAENVLSTEVPVTTPGEQKVKEYTTVAFDYGKLYLDGIPIYLFGTPGQTRLQFMWRVLAQGMHGYLFLVDGSSLLEVYRARGIYTYMKSLGNYPHIIAVNKQDVKGSVPPSRVASIFNVDPAYVAPLVARDKAMAISVLKKLVDLILTRREERVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU2</accession>
    <name>A1RWU2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751937.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0262"/>
    <dbReference type="EnsemblBacteria" id="ABL77672">
        <property type="protein sequence ID" value="ABL77672"/>
        <property type="gene ID" value="Tpen_0262"/>
    </dbReference>
    <dbReference type="GeneID" id="4601679"/>
    <dbReference type="KEGG" id="tpe:Tpen_0262"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8456" checksum="0E8516A02692109A" modified="2007-02-06" version="1">MSDPRVIVRTIGALSRLLASTLRRDGLYEARLVEALDAIEEFLASVRGATTQVEEDEELARELEEGIEELRELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU4</accession>
    <name>A1RWU4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751939.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0264"/>
    <dbReference type="EnsemblBacteria" id="ABL77674">
        <property type="protein sequence ID" value="ABL77674"/>
        <property type="gene ID" value="Tpen_0264"/>
    </dbReference>
    <dbReference type="GeneID" id="4601682"/>
    <dbReference type="KEGG" id="tpe:Tpen_0264"/>
    <dbReference type="HOGENOM" id="CLU_1640053_0_0_2"/>
    <dbReference type="OrthoDB" id="140027at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="169" mass="19299" checksum="C59664FA01132D95" modified="2007-02-06" version="1">MREENVVAISVDSGHEKQVVRDVLDLLFPYDVEVRVTGVSRGRVSLVTRIPAEDLRRIFRRYPVRHILKVKLLRKVLPLSSEVAQTLREIVSFFLEEGVKIRRISVRLEKVEGWSQSAYSLLMRELRTNGLLDSGGLLYAVETDGQAVFVFEVLFTRNPRVHSPTGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV5</accession>
    <name>A1RWV5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751950.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77685">
        <property type="protein sequence ID" value="ABL77685"/>
        <property type="gene ID" value="Tpen_0275"/>
    </dbReference>
    <dbReference type="GeneID" id="4601897"/>
    <dbReference type="KEGG" id="tpe:Tpen_0275"/>
    <dbReference type="HOGENOM" id="CLU_1140623_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="27311" checksum="CDB5852EE0E60F5F" modified="2007-02-06" version="1">MHNLRATVYCVEESLAREFILRDVSEALSEGGRVYGAVGEWLRAYLGERFAVRDICIDACTLRGLSTLYAVLKGRVTVMGYAVQASFFSRLNEKLAVLSYEDPGNAEIYGLLSSLKDAGVTFKERCAEEDLAVHLLESFPRIRRYLPLLLAAKSHVHRACLLLQLACSEVDAFSEVYSAVDNARWIVYIEDSCVVPYNPRFRIVLQPHRCSLRGAPRNLMEKLSKVDPFSVVRVEGTETAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ4</accession>
    <name>A1RWZ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751989.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0315"/>
    <dbReference type="EnsemblBacteria" id="ABL77724">
        <property type="protein sequence ID" value="ABL77724"/>
        <property type="gene ID" value="Tpen_0315"/>
    </dbReference>
    <dbReference type="GeneID" id="4602083"/>
    <dbReference type="KEGG" id="tpe:Tpen_0315"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_8_0_2"/>
    <dbReference type="OMA" id="VKYMLWL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="83" mass="9231" checksum="B2361A20E18AC352" modified="2007-02-06" version="1">MKLQVRYVSLMKDKTGKEQEEIELDAEEPTLEDLLRILEEKYGVPMLSGEEEMLVLVNGRRSGLKEKLSDGSQVVIAPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ9</accession>
    <name>A1RWZ9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA sulfurtransferase</fullName>
            <ecNumber evidence="10">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiI</name>
        <name evidence="14" type="ordered locus">Tpen_0320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="10"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751994.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0320"/>
    <dbReference type="EnsemblBacteria" id="ABL77729">
        <property type="protein sequence ID" value="ABL77729"/>
        <property type="gene ID" value="Tpen_0320"/>
    </dbReference>
    <dbReference type="GeneID" id="4600971"/>
    <dbReference type="KEGG" id="tpe:Tpen_0320"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_1_2"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="OrthoDB" id="57901at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="13">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="397"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="10">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABL77729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="484" mass="53913" checksum="51F56B4F8B51A6C1" modified="2007-02-06" version="1">MEGLREVFVVRLGEITVKSKKSRERFEKRLLENIRDALSSSGVSGEVRREYGRIYVYAPSSFAGVLRRVFGITSFSMALEYEFKALDDIASTVYNLYCDKLKGKTFAVRARRTGDHPFTSMDVARKVGEKLYPCSSGVDLSNPEVQVFIEVRGSRAYFYTDVVRGYGGLPVGSEGKVLALISGGYDSAVAAWYMLKRGAEVHYLYCNMAGDLTKSLVLSVAKKLADSWSYGYKPRLYVADFSPLLRELRAKVAPELFGVVLKRYMYRVAEAIAGRIGAIGIVTGESLGQVSSQTLENLYVASQATSMPIYRPLIGFDKEEIISKSKEIGTYEESSKVKEVCGVFSVHPKTRSRLEEVEREESKLDPAILGRVLSTVEEIDLRSATPSPLIEVDVDAPPEGSIIVDVRPKEKYEEGHIPGSLHIEFTELPLFLERLDKSKTYVFVCDEGGLSREAAYMLRKAGFNAWSLKGGLRRFSRLARESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX08</accession>
    <name>A1RX08_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0329"/>
    <dbReference type="EnsemblBacteria" id="ABL77738">
        <property type="protein sequence ID" value="ABL77738"/>
        <property type="gene ID" value="Tpen_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0329"/>
    <dbReference type="eggNOG" id="arCOG00968">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_1_0_2"/>
    <dbReference type="OMA" id="WILLEYR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="RNA_MeTrfase_TK0422/Sfm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PTHR35517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="RNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="221" mass="24789" checksum="0B42AF9F81A03317" modified="2007-02-06" version="1">MTSRTPLSNCRVDVYIEVLEPFISKWMFIELKHIATVLEPKCIHVFNVKRDCEIDVLKKVFGEVRHESVTEELRLAETYDTVIILDPSAPTPLSPEDFRGKTAVVIGGIMGSHPPRRRTREELTSKMRIGAARNIGDGQFTIDGAAYVALEVSRGRRLDEIPVQRGLSLSLKEGIEVVLPYVYPLVGGVPFISKEEELYILTELEEDESSFISEGRAPSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX39</accession>
    <name>A1RX39_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="9" type="ordered locus">Tpen_0360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0360"/>
    <dbReference type="EnsemblBacteria" id="ABL77769">
        <property type="protein sequence ID" value="ABL77769"/>
        <property type="gene ID" value="Tpen_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0360"/>
    <dbReference type="eggNOG" id="arCOG01719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030702_0_0_2"/>
    <dbReference type="OMA" id="SGFQRTM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="8">
        <location>
            <begin position="483"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="632" mass="71474" checksum="6EE1656740FA574B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX46</accession>
    <name>A1RX46_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0367"/>
    <dbReference type="EnsemblBacteria" id="ABL77776">
        <property type="protein sequence ID" value="ABL77776"/>
        <property type="gene ID" value="Tpen_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0367"/>
    <dbReference type="eggNOG" id="arCOG01182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095575_0_0_2"/>
    <dbReference type="OMA" id="KNFTSAM"/>
    <dbReference type="OrthoDB" id="104998at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="236" mass="26341" checksum="23A42884088E30B8" modified="2007-02-06" version="1">MDPECAVQRAVELSMLGVHSLCLVGSVELGSLRVIGKGTTSLVVKGLARSGVVAVKIRRTDANRVSLLREARILESVKELGVGPRIRCASRNFLVWDFINGVDFAEWVEKVASREELETVLEKLLTKLFLLDQHGIVHAELSQPSNHILVDLERLEPVLVDFESASLDSQKSNLTQFMGFLVNKGNPLSEKLRKSLGLDDPLKIENLKKLLKAYKLSRDSESFREILDYFKASIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX51</accession>
    <name>A1RX51_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hexulose-6-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752046.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0372"/>
    <dbReference type="EnsemblBacteria" id="ABL77781">
        <property type="protein sequence ID" value="ABL77781"/>
        <property type="gene ID" value="Tpen_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="4600772"/>
    <dbReference type="KEGG" id="tpe:Tpen_0372"/>
    <dbReference type="eggNOG" id="arCOG00053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081825_1_1_2"/>
    <dbReference type="OMA" id="WEQAQEW"/>
    <dbReference type="OrthoDB" id="104406at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04726">
        <property type="entry name" value="KGPDC_HPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041710">
        <property type="entry name" value="HPS/KGPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="231" mass="25138" checksum="635B02C5784930EC" modified="2007-02-06" version="1">MSRRYLVQVALDVVDEERALRVAGAMGEGCRQGAFPCDRLVVEAGTPLIKAVGVRVLPKLKLASGGLTLYADLKTADVGELEASLAYDFGADIASVLARAPMGTLKAFLEAGLKRGRLVAVDTIGIEAREVPFLVREIIRVAREIGFPLEKLVVELHRGIDEEASRQKYFEELGVAVNQIRELSPEVKIAVAGGITPAVKSLVEKLEPDIYVVGRYITQSPNVVERIKEFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX71</accession>
    <name>PSB2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome subunit beta 2</fullName>
            <ecNumber evidence="1">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20S proteasome beta subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proteasome core protein PsmB 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psmB2</name>
        <name type="ordered locus">Tpen_0392</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752066.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX71"/>
    <dbReference type="SMR" id="A1RX71"/>
    <dbReference type="STRING" id="368408.Tpen_0392"/>
    <dbReference type="EnsemblBacteria" id="ABL77801">
        <property type="protein sequence ID" value="ABL77801"/>
        <property type="gene ID" value="Tpen_0392"/>
    </dbReference>
    <dbReference type="GeneID" id="4600527"/>
    <dbReference type="KEGG" id="tpe:Tpen_0392"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="RVSYGFY"/>
    <dbReference type="OrthoDB" id="89767at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_0000397478" description="Removed in mature form; by autocatalysis" evidence="1">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397479" description="Proteasome subunit beta 2">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <sequence length="204" mass="22161" checksum="AF45C4D4B1508252" modified="2007-02-06" version="1" precursor="true">MEVLPGTTVGIRVSDGVVLAAEKRVSYGLYLMSKSGKKVYRILDKMGMASAGLMADMQTLARIVEAEMRLYELDSNISPKVWTVAKLLSYILYERRLFPYYAEIVVGGLDEEGSHLYSLDPIGAIIEDDYVALGSGTQLAISIVESNYKKDMSLDEALSLALKSVYAAMKRDAASGDGVDVLVIGKSGTLEKTYPLSELQSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX90</accession>
    <name>A1RX90_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0411"/>
    <dbReference type="EnsemblBacteria" id="ABL77820">
        <property type="protein sequence ID" value="ABL77820"/>
        <property type="gene ID" value="Tpen_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0411"/>
    <dbReference type="HOGENOM" id="CLU_2629912_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="77" mass="8406" checksum="F6816EAD2398C925" modified="2007-02-06" version="1">MGVISGKVRAVVVLSSLVLLAWLELIAFLLIVENVALKVANSLVRGLLGVLLLFTWVLLMAVAAEALRRKLARARQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA9</accession>
    <name>PFDA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pfdA</name>
        <name type="ordered locus">Tpen_0430</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXA9"/>
    <dbReference type="SMR" id="A1RXA9"/>
    <dbReference type="STRING" id="368408.Tpen_0430"/>
    <dbReference type="EnsemblBacteria" id="ABL77839">
        <property type="protein sequence ID" value="ABL77839"/>
        <property type="gene ID" value="Tpen_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0430"/>
    <dbReference type="eggNOG" id="arCOG01341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_1_1_2"/>
    <dbReference type="OMA" id="ELQNQFM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PTHR12674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000322256" description="Prefoldin subunit alpha">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <sequence length="129" mass="14579" checksum="A7BCF98734FCC063" modified="2007-02-06" version="1">MAQSRERLAEEYSVLAQVAEELQREIQLAQTLIAEVDSAILALKNISSLEDGKEILVPVSAGVYVRASIKRQEKFLVAIGSNILVEKSLDEAVEFLNKRKEELSQLVERRMNDLNKVVARIREIESSIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB2</accession>
    <name>CDPAS_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CDP-archaeol synthase</fullName>
            <ecNumber evidence="1">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">carS</name>
        <name type="ordered locus">Tpen_0433</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXB2"/>
    <dbReference type="SMR" id="A1RXB2"/>
    <dbReference type="STRING" id="368408.Tpen_0433"/>
    <dbReference type="EnsemblBacteria" id="ABL77842">
        <property type="protein sequence ID" value="ABL77842"/>
        <property type="gene ID" value="Tpen_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0433"/>
    <dbReference type="eggNOG" id="arCOG04106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105710_0_0_2"/>
    <dbReference type="OMA" id="GKTWRGT"/>
    <dbReference type="OrthoDB" id="124973at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="PTHR39650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000298289" description="CDP-archaeol synthase">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <sequence length="204" mass="22173" checksum="F46716F3A845564F" modified="2007-02-06" version="1">MRISVYACFLGLYFLVFSLIVYVILGAEFLVSVLQPGNVARSMLWVLPAYVANASPVVFSRLVRKRWRLHPMDFGLTFVDGQRLLGDNKTFEGFLGGMLSGVLVGILLAYARFVDGVSAFLLPLGALLGDLGGAFVKRRLRIKPGEPAILLDQLDFVAGALILQGLFSKLPAAEVVVAVVLLTPIVHLLTNMAAFVLGLKDVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB6</accession>
    <name>A1RXB6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0437"/>
    <dbReference type="EnsemblBacteria" id="ABL77846">
        <property type="protein sequence ID" value="ABL77846"/>
        <property type="gene ID" value="Tpen_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0437"/>
    <dbReference type="eggNOG" id="arCOG04321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064235_0_0_2"/>
    <dbReference type="OMA" id="SISPWME"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="350" mass="38110" checksum="569B6937D6039F9E" modified="2007-02-06" version="1">MRRSAGFKVRAVVLHVDLEKGGDSLEEKLAAFTEAVKAFSETTGVDVWTKRVVANPVPPESFEKAVHALYSAAEPSGINYVAVPQRRPLTPEVLADVMDSYERLYSSATYDDNSTATLVSTVKALSERSPLMAARYAVSFGGFIQTPYFPATATSVEGVSLSLLYPKFLSENPLSKVSETFSGLAARAEKTLPGFLGIDFSLSPWEDESVALLVEKVSGTTLGSPGTIRAIRELNRRINLLAHEARAVGYNEVMLPLAEDNRLKELAKTGQLRFSHLLNYASYCVAGLDMVVIPDTTEDKVLENILLDLSEIQKLKGRILGLRLILAPAEEGDEVEVGFFGKIPVISPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC2</accession>
    <name>A1RXC2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77852">
        <property type="protein sequence ID" value="ABL77852"/>
        <property type="gene ID" value="Tpen_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0443"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8454" checksum="E73B40E6FB9B5629" modified="2007-02-06" version="1">MSDPRVTVRTIGALSRLLASTLRRDELYEARLVEALDAIEEFLASVRSAPQVEEDEELARELEEGVEELRRLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC3</accession>
    <name>A1RXC3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752118.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0444"/>
    <dbReference type="EnsemblBacteria" id="ABL77853">
        <property type="protein sequence ID" value="ABL77853"/>
        <property type="gene ID" value="Tpen_0444"/>
    </dbReference>
    <dbReference type="GeneID" id="4601867"/>
    <dbReference type="KEGG" id="tpe:Tpen_0444"/>
    <dbReference type="eggNOG" id="arCOG01038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_0_0_2"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="110798at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="183" mass="20207" checksum="0F1842E95C1C929E" modified="2007-02-06" version="1">MAVLITGTPGVGKTSVAQSLASTLGKKYVDVAKLAAENNLVKGFDPELQAYIVDTSSVRALLEEILTCNEVVDTHIVECVPKRKVTHVIVLRLNPLELKKRLEARGYPNRKIAANVEAEVLDSVLIDAVKWFGERKVFEVDTTGKSVGEIVNIVRLVLEGKGRNFKPGNVNWLENFYYLLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE2</accession>
    <name>A1RXE2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein Tpen_0463</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752137.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0463"/>
    <dbReference type="EnsemblBacteria" id="ABL77872">
        <property type="protein sequence ID" value="ABL77872"/>
        <property type="gene ID" value="Tpen_0463"/>
    </dbReference>
    <dbReference type="GeneID" id="4600990"/>
    <dbReference type="KEGG" id="tpe:Tpen_0463"/>
    <dbReference type="eggNOG" id="arCOG04308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165882_1_0_2"/>
    <dbReference type="OMA" id="RTIIWEV"/>
    <dbReference type="OrthoDB" id="116790at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="87" mass="9680" checksum="0CC88D8C5C927E9F" modified="2007-02-06" version="1">MADVVPQIKNAIELLKQIADDRGIPRNIRRVATESIEVLMDPQMTPGLKAATVISKLEDISSDPNTPLFARTKIWQIISLLEQVKDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG4</accession>
    <name>RNP1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease P protein component 1</fullName>
            <shortName evidence="1">RNase P component 1</shortName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnp1</name>
        <name type="ordered locus">Tpen_0486</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752159.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXG4"/>
    <dbReference type="SMR" id="A1RXG4"/>
    <dbReference type="STRING" id="368408.Tpen_0486"/>
    <dbReference type="EnsemblBacteria" id="ABL77894">
        <property type="protein sequence ID" value="ABL77894"/>
        <property type="gene ID" value="Tpen_0486"/>
    </dbReference>
    <dbReference type="GeneID" id="4601784"/>
    <dbReference type="KEGG" id="tpe:Tpen_0486"/>
    <dbReference type="eggNOG" id="arCOG00784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107020_2_1_2"/>
    <dbReference type="OMA" id="WHELIGL"/>
    <dbReference type="OrthoDB" id="124913at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000046619" description="Ribonuclease P protein component 1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <sequence length="94" mass="10530" checksum="7F8101FA4CD78DEE" modified="2007-02-06" version="1">MKITPKNILRHELIGLEACVVKSKNPSQVGICGLILDETYKTIVIGVPGGPKKRIFKAQVVLRIKLPDGKELLVDGAFLVGRPEERLKRRVMLW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH8</accession>
    <name>DNAG_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name type="ordered locus">Tpen_0501</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752173.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXH8"/>
    <dbReference type="STRING" id="368408.Tpen_0501"/>
    <dbReference type="EnsemblBacteria" id="ABL77908">
        <property type="protein sequence ID" value="ABL77908"/>
        <property type="gene ID" value="Tpen_0501"/>
    </dbReference>
    <dbReference type="GeneID" id="4601335"/>
    <dbReference type="KEGG" id="tpe:Tpen_0501"/>
    <dbReference type="eggNOG" id="arCOG04281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OMA" id="KYMIVAQ"/>
    <dbReference type="OrthoDB" id="23182at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0271">Exosome</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000000567" description="DNA primase DnaG">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="426" mass="46981" checksum="CBE8982F7ACB51B5" modified="2007-02-06" version="1">MGGLPVSPKYVIKAKMEIKGSVEKHDIIGAIFGQAEGLLGSELDLRELQKTGRVGRIEVNTRSQDGTLVAEIEIPTNLDMAETAIIAATIESIDKVGPYPAKTEVVSIEDVRAEKRQKIIERAVELYKKLLESVPESRELVEEVLRRVRVAEIVEYGEEKLPGGPEVETSDTVILVEGRADVQNLLRHGYKNVIALGGATIPKSIKSLVENKKVILFVDGDRGGELIARNVINALKVDFVARAPPGREVEDLTAKEIARALQNKIPVDEFLQALEREKKQQKEVKAEIVVPPAKLIKSATKKNPEIAQEIVVPAEVYEKLEELKGTLEAVIYDENWQVVEKVPVRDLVNRLKEVERAAHVVLDGIITQRLVDVAYTKGLKSLIGVRIGEIIRKPDNIVLATFSSVKKSEENIQESVSTGESAQTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ9</accession>
    <name>A1RXJ9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">Tpen_0523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0523"/>
    <dbReference type="EnsemblBacteria" id="ABL77929">
        <property type="protein sequence ID" value="ABL77929"/>
        <property type="gene ID" value="Tpen_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0523"/>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_2_2"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="292" mass="31982" checksum="E251C2D1A4BF2159" modified="2007-02-06" version="1">MSFRKVWMKARANDPVVLEHARLLYRYLTDRGLDVYVDPLLGHVIPGRSLSELEAREADLGIVVGGDGTLLRTVQKSNAVLPPILGFSSDSLGYLLPHRVDVAREVLEEVLRGNYSERDVALGEFIAGERAGVFLNEVCVWSEPGKIVEFEVLLNDESLYRVRGDGVIVATPAGSTGHAFSYGGPVIIDTGQRALEVVFPGALSPLIRPLIVHGGSIAVKVIAHPANLVVDGQVYSKLQEASKVTVRPSSKSLRFIYVEKYETPLPEKLARRVLDRGLSYVVSSLFKQTPKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN2</accession>
    <name>PELO_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein pelota homolog</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pelA</name>
        <name type="ordered locus">Tpen_0556</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABL77962" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77962.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXN2"/>
    <dbReference type="SMR" id="A1RXN2"/>
    <dbReference type="STRING" id="368408.Tpen_0556"/>
    <dbReference type="EnsemblBacteria" id="ABL77962">
        <property type="protein sequence ID" value="ABL77962"/>
        <property type="gene ID" value="Tpen_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0556"/>
    <dbReference type="eggNOG" id="arCOG01741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000361825" description="Protein pelota homolog">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="352" mass="38990" checksum="20AE46FB6AB5B5AD" modified="2009-02-10" version="2">MRVLGLNQERGEVELVVEVLEDLYYLFLLVRKGDVVYGWTTRQLRIERATGEERGERIPVYLGVEVEKVSYAKFSEKLRFTGRVVEAPEEVYAKGSFHTIQVGVGDRVKIVKKSGIDGFTRNILEKAASKIRRVLLISVGDEEVAVGYLSPVGVEVRAVVGYSPVGRGKESSLDERYREPIASIVQRIFESGRAEHVDEVVVAVNERLAEVVSRVLGELGVKARVVKVSEGGEAGIYELLRGGQSRELLSSVRLPLELAEVERVLQELFSGKGKAVAGLENVEKVAEWGIVKTLIVSDALLFGEESRERVLKVLGEVFSRNGKIFIVPEESEAGRKLKPFGGALAELYYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS2</accession>
    <name>A1RXS2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="11">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moaA</name>
        <name evidence="13" type="ordered locus">Tpen_0597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="11"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0597"/>
    <dbReference type="EnsemblBacteria" id="ABL78002">
        <property type="protein sequence ID" value="ABL78002"/>
        <property type="gene ID" value="Tpen_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0597"/>
    <dbReference type="eggNOG" id="arCOG00930">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_2"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_A">
        <property type="entry name" value="MoaA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013485">
        <property type="entry name" value="MoaA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02668">
        <property type="entry name" value="moaA_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="348" mass="38670" checksum="216CD43B09E933B9" modified="2007-02-06" version="1">MQHFSARYVLVDRFGRPLENLRITVTPQCNFNCVFCHGEGEPPNNALLSASEIVEVASVAHSLGVGTFKLTGGEPLLRKDLERIVAGLKSFGRGVEVSLTTNGFFLEKRVPSLVEAGLDRVNVSLHAFDPEVFEGVTRVKGFEKVLRGLEAASEYGLPVKLNFVLTKLNAGQLGEVLDYASRKGFNVNLIELIPTGKGGAVFDELYVPVENVLPQLEGMARKVYTRPLQSRPVFELETGIKVEVIANYCNPAFCSMCTKLRLTHDGKLKPCLNRNDNLVDLTPILRDEGGDKLERLREAFLIANSRREPFFRFNGEKVTSFNGRIVCPVRRVTLLSNARGPRREALPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS9</accession>
    <name>TIAS_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name type="ordered locus">Tpen_0604</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752274.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXS9"/>
    <dbReference type="SMR" id="A1RXS9"/>
    <dbReference type="STRING" id="368408.Tpen_0604"/>
    <dbReference type="EnsemblBacteria" id="ABL78009">
        <property type="protein sequence ID" value="ABL78009"/>
        <property type="gene ID" value="Tpen_0604"/>
    </dbReference>
    <dbReference type="GeneID" id="4601224"/>
    <dbReference type="KEGG" id="tpe:Tpen_0604"/>
    <dbReference type="eggNOG" id="arCOG01115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675459_0_0_2"/>
    <dbReference type="OMA" id="GMCTTYL"/>
    <dbReference type="OrthoDB" id="58019at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000407305" description="tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OB" evidence="1">
        <location>
            <begin position="278"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <sequence length="445" mass="49096" checksum="91E432DAF702476A" modified="2007-02-06" version="1">MGLTSVHVGLDDTDSPLGLCTTFVALAIVREASRIGAGFADLPYLVRLNPNVPLKTRGNGAVAIHFLVEEELVPRVEEAVVRALDDLSERHGKTDPAAILVKGDVPRAFRSVYLRALTEFIPSSYVRSVLERFKGESVKLLYSRSKRPRGLVGAVASLGAYPLEDYTYELIVYRSPEERSESRDISEDLLLELDRKYRPLVFATYDYSSRRVLAVPHGPDPVIFGLRSLDPEILVNVAVDVLEKISHAGYLLFKTNQGTSAHLQRYKPVALVRPYDSVVVRGSVAEKPTVISGGHVIVNVCDETGCLQIAFYKETGRLNRVAKLLSRGDLVEVGGGVMKKDGLVLNAEYLRLIKPALNVKRLNPLCPKCGSRMTSAGKGKGYKCPKCGYRAKEAAKIYRVAPRTLEPGTYFQSPSAYRHLTKPPEILGLRPVDATKVLLSGMWFM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-01-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU2</accession>
    <name>MTAP_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="1">MTA phosphorylase</shortName>
            <shortName evidence="1">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnP</name>
        <name type="ordered locus">Tpen_0618</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752287.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXU2"/>
    <dbReference type="SMR" id="A1RXU2"/>
    <dbReference type="STRING" id="368408.Tpen_0618"/>
    <dbReference type="EnsemblBacteria" id="ABL78022">
        <property type="protein sequence ID" value="ABL78022"/>
        <property type="gene ID" value="Tpen_0618"/>
    </dbReference>
    <dbReference type="GeneID" id="4601324"/>
    <dbReference type="KEGG" id="tpe:Tpen_0618"/>
    <dbReference type="eggNOG" id="arCOG01327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="63298at2157"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000415110" description="S-methyl-5'-thioadenosine phosphorylase">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <sequence length="262" mass="29467" checksum="0805BD30C4FB86E6" modified="2007-02-06" version="1">MEKVKIGIIGGSGLYSPDFLTNPKEEKIYTPYGPPSSHVVIGEIAGRKVAFIPRHGKRHEIPPHKVNYRANIYALKELGVERLISVSAVGSLREDYKPGDFVCTDQFIDMTKGRVYTFYDGPVVAHVSMADPFCPELRELCIRSARKLGITMHEKGTYICIEGPRFSTRAESRLWRQFGADIIGMTLVPEVNLAREARMCFLNIAMVTDYDVWAEKPVTAHEVARVMAENTEKVKRLLADLIPSIPEERKCQCARALDEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX0</accession>
    <name>A1RXX0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ordered locus">Tpen_0648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0648"/>
    <dbReference type="EnsemblBacteria" id="ABL78050">
        <property type="protein sequence ID" value="ABL78050"/>
        <property type="gene ID" value="Tpen_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0648"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_1_2"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="12673" checksum="AD2B5FD0708DEA37" modified="2007-02-06" version="1">MRSRWVAVPSKVRIRLSSTNIEDLNAVCEEIRQIAQKTGVKMRGPIPLPVKRMRVVTRRAPSGQGYETFDRFELRIHKRLIDLDADERATRLLLRTRVPPTVRVEIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY0</accession>
    <name>A1RXY0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752325.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0658"/>
    <dbReference type="EnsemblBacteria" id="ABL78060">
        <property type="protein sequence ID" value="ABL78060"/>
        <property type="gene ID" value="Tpen_0658"/>
    </dbReference>
    <dbReference type="GeneID" id="4601616"/>
    <dbReference type="KEGG" id="tpe:Tpen_0658"/>
    <dbReference type="eggNOG" id="arCOG00951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048071_0_0_2"/>
    <dbReference type="OMA" id="CIFCSVD"/>
    <dbReference type="OrthoDB" id="68339at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040088">
        <property type="entry name" value="MJ0103-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF35">
        <property type="entry name" value="PTHR11228:SF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01110">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="336" mass="37562" checksum="42EB2D450700DE9B" modified="2007-02-06" version="1">MARYFLKVEEGLPLVGHLAFGIVDRGTNLLQIRPTSFCPLSCVFCSVDAGPRSTRRLTEFLVDHEYLVSWFVDVAKAKGLDKAHAYIDAVGDPLTYGRIIELVRLLSSTGVAESITIETHGALLTRELVDKLADAGLTRINLSVDALDPSLARTLAGTPWFDVNRVISVAEYIASSTDIDLLIAPVWVPGVNDSEIPRIIEWALRIGAGKRVPPLGIQKYEEHKYGRKPPGVKPMKWHEFYSKLEVWEKEYGVRLRIRPEDFGIRKARALPLAFRKGEKATVSVVYWGWLKGQWLGVARNRVITIVGVPGAPPIGRKVKVRMLRTRSNIYVARLEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY04</accession>
    <name>NFI_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name type="ordered locus">Tpen_0682</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752349.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY04"/>
    <dbReference type="SMR" id="A1RY04"/>
    <dbReference type="STRING" id="368408.Tpen_0682"/>
    <dbReference type="EnsemblBacteria" id="ABL78084">
        <property type="protein sequence ID" value="ABL78084"/>
        <property type="gene ID" value="Tpen_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="4601882"/>
    <dbReference type="KEGG" id="tpe:Tpen_0682"/>
    <dbReference type="eggNOG" id="arCOG00929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_2"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="OrthoDB" id="80668at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000047006" description="Endonuclease V">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <sequence length="232" mass="25905" checksum="9ECA368C803B57BF" modified="2007-02-06" version="1">MRVHRLPENFSLERARRAQLAIARMVLEEDSLPESVRRAAGVDVAFKGDYAFAAAVVVEYPSFSVVDYSVTRTEVRFPYVPTLLAFREVWPAYTALKRLKSEPDVLLVDGNGRLHPFKAGFACHLGVLVDKPTIGVAKKLLVGEVGSWKSGVAPVLYRGEVLGMAVKTSERSKPVFVSIGHKISLNTAVWIVRMFTKRGLRLPEPLRLAHLYATAYARGNMEEKDFYLDEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY06</accession>
    <name>A1RY06_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="6">PTH</shortName>
            <ecNumber evidence="6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pth</name>
        <name evidence="7" type="ordered locus">Tpen_0684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752351.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0684"/>
    <dbReference type="EnsemblBacteria" id="ABL78086">
        <property type="protein sequence ID" value="ABL78086"/>
        <property type="gene ID" value="Tpen_0684"/>
    </dbReference>
    <dbReference type="GeneID" id="4601884"/>
    <dbReference type="KEGG" id="tpe:Tpen_0684"/>
    <dbReference type="eggNOG" id="arCOG04228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="115947at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00628">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034759">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="12938" checksum="77DCAE95DD699121" modified="2007-02-06" version="1">MGSLKQVIVLRRDLDMGKGKMVAQGCHASVSAVLETLKRNREIVERWVEEGQRKIVVRVDSEEELLSVYRKALELGLVAVLVEDKGLTQLPPGTPTAVGIGPADEEIIDKVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY12</accession>
    <name>A1RY12_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
            <shortName evidence="5">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tfb</name>
        <name evidence="9" type="ordered locus">Tpen_0690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0690"/>
    <dbReference type="EnsemblBacteria" id="ABL78092">
        <property type="protein sequence ID" value="ABL78092"/>
        <property type="gene ID" value="Tpen_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0690"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RTQKDFA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="327" mass="36605" checksum="41D3A18141AE4513" modified="2007-02-06" version="1">MGFGRESMVEERKENVNPEDSEEERELRCPNCGSTRLIYDATRGEIICANCGYVMSEREIDQGAEWRAFTPEEREKRSRVGAPISRYGVESLVTDIDWGGRDAAGREISLRKRIEMLRLRKWQVRARAQSSMERNLAQAVIELERLGAQLGLPKAVLDRALDIYKSALDSNLVRGRSIESVMAAAVYAACREMRLPRTLDEIALYTRAGRKDVARCYRLLLREASLKVPLPNAADFVPRIGSLLRLSGATIKRAMEIIDQARNAGLTAGKDPAGLAAAAIYIAALQNGEMRTQKEVARAAKVTEVTVRNRYKELVKKLDIKLPVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY38</accession>
    <name>A1RY38_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752383.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0716"/>
    <dbReference type="EnsemblBacteria" id="ABL78118">
        <property type="protein sequence ID" value="ABL78118"/>
        <property type="gene ID" value="Tpen_0716"/>
    </dbReference>
    <dbReference type="GeneID" id="4601480"/>
    <dbReference type="KEGG" id="tpe:Tpen_0716"/>
    <dbReference type="HOGENOM" id="CLU_854243_0_0_2"/>
    <dbReference type="OrthoDB" id="137790at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="325" mass="36019" checksum="26354C2FA16E6C9B" modified="2007-02-06" version="1">MTCVRVSGSGYFALSMLYWLRKVSPRLRVYLEGSSLSGVSTPRSLRMLALGVEGREASIESLLRLFYPDLAWKSSPLEPCYEVIVEEPSVNGVKLSSIYAENHRLTPGTVAPPCAQAAQLAIYARRLGAPLRLRGRVAEVFEEDALSLLNKLLGNYGLLTEEPGSVDRSACLPGSLVFRTPTGEEERFSVYPFFDENIEQYAAYLAFRIAGYEDLVGRPEPLVLLEDPGNNVLLYVYESPGDTSVKTQVEGGWCRVSASSDSRRVAGIQCCAAPRVDLFEKVFSLLLDGRDICSFMPFLAATRSPLLRESRYLRSLLALFFKVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY42</accession>
    <name>A1RY42_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752387.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0720"/>
    <dbReference type="EnsemblBacteria" id="ABL78122">
        <property type="protein sequence ID" value="ABL78122"/>
        <property type="gene ID" value="Tpen_0720"/>
    </dbReference>
    <dbReference type="GeneID" id="4601485"/>
    <dbReference type="KEGG" id="tpe:Tpen_0720"/>
    <dbReference type="eggNOG" id="arCOG00281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791360_0_0_2"/>
    <dbReference type="OrthoDB" id="82249at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="351" mass="39651" checksum="EFD227C6E8F6F9EB" modified="2007-02-06" version="1">MTSGLAYRLLRAAAGRRIYALTGDLAILSPFAVLPPSEESGGLFLGRDDRGRNVYLNPEKLPNMHGVILGTTGSGKSSLARHIMLEARRLGVTSWVIDPHSEATYRKLFERSFGLGDFRVNVLEAPGWGASELASELSRYIEAIYGFPGYRSILREILKRCFEEGSLEFFEKVSKEDPNLLRIYDDLSRIHSNEGASIAELTRDVYFYYPALVSREFLALSSQILLLLLEGYMRTKGARHRLEHLVVLEEAHLVKDYILSLFKQVRKYGWGLLAVTQLPREMDPRVYQLAGFLVVLSGPESFVLDVARVVQLTRLDYDHLLYSARGNALLVRQGDPRPRRIHLELHSSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY67</accession>
    <name>A1RY67_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NFACT-R_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752412.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0745"/>
    <dbReference type="EnsemblBacteria" id="ABL78147">
        <property type="protein sequence ID" value="ABL78147"/>
        <property type="gene ID" value="Tpen_0745"/>
    </dbReference>
    <dbReference type="GeneID" id="4600396"/>
    <dbReference type="KEGG" id="tpe:Tpen_0745"/>
    <dbReference type="eggNOG" id="arCOG01695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_2_1_2"/>
    <dbReference type="OrthoDB" id="69351at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="1">
        <location>
            <begin position="410"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="610" mass="66564" checksum="6FEC3B6608457A81" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB1</accession>
    <name>A1RYB1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0789"/>
    <dbReference type="EnsemblBacteria" id="ABL78191">
        <property type="protein sequence ID" value="ABL78191"/>
        <property type="gene ID" value="Tpen_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0789"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="470" mass="54096" checksum="F97DA5368FFF7C97" modified="2007-02-06" version="1">MVDMMGYEEIEKTVREETWRRAALSLYATRTEDKRRGRTHYRGLFDTVTEVDWDFTRFLVNGYTVVPDEAYPRFSKLFDYDARQYLLLNDDERPREGGAVIELRGRLQAIVDAGADGLRAERHGRHWRVYVPHENWHVVVSKPTNGWSVHVPLEGYWTETSFPEVLVRTSPDVLRSLQRGWILTDVTPPHGRHSDVRFSTTQPWQLPATLAAFPSGNIRLGVTAGILGSTRLSIEWHVLVYGYEEELGWASRLVGEVKRVEYRRLVEECKALNGDSVALLTAYEGDGILAYFLRMRELYFRIRHEIVYLPAESAIVNARLAVERASEYTKFVSLVTKCAKIKHFLFVGYGIPQKRGRKNGQKNNPFYAEIAGAKLHVVYYTADNRIYARIVVDAVPLGWVEEARAQGWDVRVVRMGSKEYYQVTHNSLFEHARSDAKLRATLLAFTRYKATQYPKAQSLVKLLEELGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC7</accession>
    <name>A1RYC7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein probably involved in trehalose biosynthesis-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752472.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0806"/>
    <dbReference type="EnsemblBacteria" id="ABL78207">
        <property type="protein sequence ID" value="ABL78207"/>
        <property type="gene ID" value="Tpen_0806"/>
    </dbReference>
    <dbReference type="GeneID" id="4602137"/>
    <dbReference type="KEGG" id="tpe:Tpen_0806"/>
    <dbReference type="eggNOG" id="arCOG07490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632568_0_0_2"/>
    <dbReference type="OMA" id="DMWQYTQ"/>
    <dbReference type="OrthoDB" id="86762at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="441" mass="49348" checksum="3F37F66D013BE996" modified="2007-02-06" version="1">MEVFFPARKRWLRGKHAPARVTASATPLSGDAYLVRVVSNGDEYLLPVARCSCSEKYAVMLEGSMFCEAEYCPGFLEELLSGRFEAVKLRLFDDFEGRAVLVGAVAEDATNPHVAYEIGGRKVLLKGYRLLRRDNPEPLFLEYLSGSGVAPRLFAAYSYGGYTLGVFMELVEGAVDPGSVLYATAVDVAKGVGDSAAQRDLLGSIGEAVAGFHLAMERCTSDWCAPSPVVESDVELWYRRMLFYLQSLAEVVPGGWLSELRRRVEGSREYLQGFVGSTKLRIHQDLHFSQMLFKPPGRVYLLDFEGEPGRPQEFSTVLEPAARDLASLARSLSYIAFFSLKEAEELSNERVVEEFVSGSTGARRLLEWSLEVLERILGSYASRVHRRLFPADPGSRLSLLHPWVLERALYEAYYEKMYRPENVYVALSTAIAYLRSEKFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE3</accession>
    <name>A1RYE3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0822"/>
    <dbReference type="EnsemblBacteria" id="ABL78223">
        <property type="protein sequence ID" value="ABL78223"/>
        <property type="gene ID" value="Tpen_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0822"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="303" mass="34243" checksum="EBC384B13AFC850A" modified="2007-02-06" version="1">MVEYEARFSKPYYNKFGEKIYLDQMTMSELLERVKKNDIVLVPCGSVESHGLGQATGEDTIIGAYIAERVAFETGITVAPPIFYGSHPSHHYGMPGTIPIKKEAYIDYVTSVVKWLSHAGFKKIILFNSHGQEYVLPIVKDKAIIEEGVKALILVTSWWAWVRDILRQGTELKPGLVLETPFIHADELEASVLWYVAPKLVDPSKLKESDAEKMVGVIPDKWADKAGNVYGRPFGWYDISAFMEIHHYPKGSVGYPSKASREKGEVVVETAIQRIIEFIEWLHKTYPPGVVPQVWPNPGDFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE5</accession>
    <name>A1RYE5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras superfamily GTP-binding protein YlqF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752490.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0824"/>
    <dbReference type="EnsemblBacteria" id="ABL78225">
        <property type="protein sequence ID" value="ABL78225"/>
        <property type="gene ID" value="Tpen_0824"/>
    </dbReference>
    <dbReference type="GeneID" id="4601827"/>
    <dbReference type="KEGG" id="tpe:Tpen_0824"/>
    <dbReference type="eggNOG" id="arCOG00350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_2_2"/>
    <dbReference type="OMA" id="EWQTGRF"/>
    <dbReference type="OrthoDB" id="87919at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="261" mass="29149" checksum="765D569A099E7CE7" modified="2007-02-06" version="1">MSLRDVKRVIARADVVVEVVDARDPWATRSPEIERYAVRLGKPLLVVVNKSDLVPRDVLEKWRKVLEKHFPVVFISATKRMGTRMLWRSLRRVAPRKPRGKPVVAAVVGIPNVGKSTIINYLKGSHSVGTSPIPGFTKSITRLRAAGWLRVIDTPGVVPRMSQEELALRGALRPESLDDPVPAAKKLLELIMCKKPGLLKELYDVEAEDPVVFLENLARRRGLLGKGGVPLVEEAARIVLRDWQTGKNTFYLEPEDYGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF9</accession>
    <name>A1RYF9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752504.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0838"/>
    <dbReference type="EnsemblBacteria" id="ABL78239">
        <property type="protein sequence ID" value="ABL78239"/>
        <property type="gene ID" value="Tpen_0838"/>
    </dbReference>
    <dbReference type="GeneID" id="4601547"/>
    <dbReference type="KEGG" id="tpe:Tpen_0838"/>
    <dbReference type="eggNOG" id="arCOG04488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144084_1_0_2"/>
    <dbReference type="OMA" id="DEIYFET"/>
    <dbReference type="OrthoDB" id="118310at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007256">
        <property type="entry name" value="DUF369"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006456">
        <property type="entry name" value="UCP006456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="127" mass="13945" checksum="B650DA88DB3BD3FC" modified="2007-02-06" version="1">MPKLKVIFPESIGVVEVELTGKNPKTLDAIVKATPFESRVNLWGDEIYFSTPARVGQEVGQEVVEKGDVAYWPPGRALCIFFGPTPASRGGEIRPASPVNVIGRVVGDLERLKRVRSGEPVRVEYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ4</accession>
    <name>A1RYJ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0873"/>
    <dbReference type="EnsemblBacteria" id="ABL78274">
        <property type="protein sequence ID" value="ABL78274"/>
        <property type="gene ID" value="Tpen_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0873"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="490" mass="55413" checksum="BE4632123F47025B" modified="2007-02-06" version="1">MSGRGMTGGEEGEEVVRKLVYGRAAQSLYATRTEDKRRSRGGKKGRVHYRGLHDAVTEINWDFTRFVAHALSVVPDEVYPRFGRLFDYDLRQYLLLGDSERPREGSAVVELKGKLQAIVDATEDGLKVERHGKIWRVYPPRENWHVTVSRPNAHSWTVHVPLEGYWVESEFPEVLARTSPDILRSLQKGWLLTDVMPPRESYLYVSFSTTQAWQLPATLADFPSDDVHLGIRAGVLGSTKMSIMWGVSIYGYAEELSWASRLVGEVKRAEYRSLVEECKALNGDSVALITAFLGDGILAFFLRLRWLYFRVGNEIVYLPTESAVFNARVAVERASEYVAFVGKVTRCAKVRHVLFVAYGAPGKRGRKPGQKVACQWLGLYAPVAGALLNLVMVTVGDEYAYIYARIPVDSAPPGWYQRALEEGWDVRVVRMSDREYYQIPQDSLFEHAGENPELWEALYRFAVAKAQAKPAARKLVEELLRFKPAGAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP2</accession>
    <name>A1RYP2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0921"/>
    <dbReference type="EnsemblBacteria" id="ABL78322">
        <property type="protein sequence ID" value="ABL78322"/>
        <property type="gene ID" value="Tpen_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0921"/>
    <dbReference type="eggNOG" id="arCOG08836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040595_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="30274" checksum="29C0CF1B1F52AF1B" modified="2007-02-06" version="1">MPQPLSMQGSMRKAISPVIAAVILTSIMLTIVSVALYYSTSLIDMNRQTMEYEYAKEQLTYAATALEQVAFGTGGSRYVRFSLTSTGISFEKASSPLSVWVWGVQGGGIQQVFSGYPLRLKVCGGPLVTTSPRLLYPESGDLQGELKKLIVESGEPIVVVYENFSQRACAYMYTRVRVFYNGQINVTVGGSVKRYNFFTIHVVVLKPGYLGGSGTIPVVFRNVGLNVTEYKFDGSSDLAVLAEQGTLQQQVKLPRAPEGAPADGLVVVVKVATVEVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR3</accession>
    <name>A1RYR3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752608.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0943"/>
    <dbReference type="EnsemblBacteria" id="ABL78343">
        <property type="protein sequence ID" value="ABL78343"/>
        <property type="gene ID" value="Tpen_0943"/>
    </dbReference>
    <dbReference type="GeneID" id="4601072"/>
    <dbReference type="KEGG" id="tpe:Tpen_0943"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OMA" id="PVGVWQI"/>
    <dbReference type="OrthoDB" id="17407at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="316"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="418" mass="46807" checksum="8B666301DBBB9859" modified="2007-02-06" version="1">MEEPRFPGVVSRPSPYLCARCKGSRRLCGLPYCPILVRARELAGVYERVRGRRELEAPSPPSVLVGEKGYPYIRVGVNLVGGEEGSPSLYEDPGAWWGRLDLYEVLRLRASMVYSYGVYSASRAVGRVGESVREAALSLKPVESEAVFRRPPDFSMRFDPLLKPVGFSAEVERLSVVSNPYIPRRVDQLIEDRVKASRAAVELYERGFDVYYIQRVLSSGALGVSKKFVPTRWAITAVDRLIGDYLLGKVKGYPEVSSYELYHSSYIGNYYSLLLMPGKWSLEMVEVWLPNSVWVPGSEPYVSTVHEWSDGKPSGEDGGYEAIRLAVLEHLAKRGRVASVLAVREITPEYFAPVGNWQIRESVRAALRGGGESFPSLGEALEALKEKLRVPLNLVLSRSTLLAARTRQRSITEFLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT1</accession>
    <name>A1RYT1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752626.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0961"/>
    <dbReference type="EnsemblBacteria" id="ABL78361">
        <property type="protein sequence ID" value="ABL78361"/>
        <property type="gene ID" value="Tpen_0961"/>
    </dbReference>
    <dbReference type="GeneID" id="4600765"/>
    <dbReference type="KEGG" id="tpe:Tpen_0961"/>
    <dbReference type="eggNOG" id="arCOG03167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_2_0_2"/>
    <dbReference type="OMA" id="HSMDLAE"/>
    <dbReference type="OrthoDB" id="21850at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="58"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="321"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="518" mass="60464" checksum="2D4EC89369A8A461" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT2</accession>
    <name>A1RYT2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0962"/>
    <dbReference type="EnsemblBacteria" id="ABL78362">
        <property type="protein sequence ID" value="ABL78362"/>
        <property type="gene ID" value="Tpen_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0962"/>
    <dbReference type="eggNOG" id="arCOG07831">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3039260_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="54" mass="5990" checksum="D928C8AB738F7BB6" modified="2007-02-06" version="1">MKRKVGNAIVVKVLHHHGGVNTLLVSMARRAKVEVQRCGDTVDLDSILRERGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV6</accession>
    <name>A1RYV6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0986"/>
    <dbReference type="EnsemblBacteria" id="ABL78386">
        <property type="protein sequence ID" value="ABL78386"/>
        <property type="gene ID" value="Tpen_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0986"/>
    <dbReference type="eggNOG" id="arCOG06121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890313_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="122"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="312" mass="35433" checksum="6A9D1E40F3DFFA8B" modified="2007-02-06" version="1">MYSSRVFYGTTPWVMLSMEMLVLATSVMMVFATTFAYFAAMHGGFKRLEHVLVFRILIVLGLVAALLVFVPHMVWYCALEASRMPVAAAIIALVYFSSSPLMEIIRLRRAKKLEKRYVEIGGRGYEYWVVDSDVLNACRKGREICVTRKLAEVFEVDELKVVLLHEEGHDGIFDKVVVVGRIILLSSLIILITDAFMLDAEMFFSSLSAYLLAIPAATLASWVNEHVADLNAAKMFPPELVVRTFVKFWACAVLRDLCTREVVNVVVFKNIQEPTFRKVLWEVARSMLDSLRGNLSIHPPPRFRIYAVLVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW2</accession>
    <name>A1RYW2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752657.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0992"/>
    <dbReference type="EnsemblBacteria" id="ABL78392">
        <property type="protein sequence ID" value="ABL78392"/>
        <property type="gene ID" value="Tpen_0992"/>
    </dbReference>
    <dbReference type="GeneID" id="4601968"/>
    <dbReference type="KEGG" id="tpe:Tpen_0992"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_1_1_2"/>
    <dbReference type="OMA" id="YEDIDYY"/>
    <dbReference type="OrthoDB" id="120852at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="138" mass="15243" checksum="18F59F3621C67234" modified="2007-02-06" version="1">MSGELVARLKRRALDFLDEALSAKNADLAAFFLEQAAQLYVKATLLELVGRETRGHGVRELLGLLARELESYGFGEAAGRILGFVDGRRRELVLLEEAYTASRYGEAEYSAKDVERLAATVKDLIKLLDEVAENVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX7</accession>
    <name>A1RYX7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1007"/>
    <dbReference type="EnsemblBacteria" id="ABL78407">
        <property type="protein sequence ID" value="ABL78407"/>
        <property type="gene ID" value="Tpen_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1007"/>
    <dbReference type="eggNOG" id="arCOG00474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031500_2_0_2"/>
    <dbReference type="OMA" id="KTVYMAV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="26909" checksum="1A33F8DBF99623EE" modified="2007-02-06" version="1">MDPREEKMRIREEVWERLVRSGAALPPFPVRGRIPNFRGADAAARRLVESEVFRKARVVFCNPDSPQRYVREAVLRHGKTLIMASPRLREGFLILDPGRVPEEEYRYASTIRGAFAYGEKVLDSLPRVDLKVAGSVAVDRVGGRVGKGGGFSDLEYAILRTLNALSDETPIVTTVHDLQVVEKVPMDVHDVPVDYVFTPTTHFKTARAYPRPPGILWERLREEDLREIPVLRILAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY9</accession>
    <name>A1RYY9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752684.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1019"/>
    <dbReference type="EnsemblBacteria" id="ABL78419">
        <property type="protein sequence ID" value="ABL78419"/>
        <property type="gene ID" value="Tpen_1019"/>
    </dbReference>
    <dbReference type="GeneID" id="4601634"/>
    <dbReference type="KEGG" id="tpe:Tpen_1019"/>
    <dbReference type="HOGENOM" id="CLU_805662_0_0_2"/>
    <dbReference type="OrthoDB" id="116550at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="344" mass="38622" checksum="6CC2F874BD9C2D51" modified="2007-02-06" version="1">MKRLRTLEYEVLKAAVVARRYVDIARSTGTSPSYAARVLARLEEKGFRVRGGFDYRVLSLQETFILAPYSPSVYEKVVPFVVEKAIVEPSKKRRLIALRVLVPVGAAEEVLDILQLEPEVFSEVERFTWNPYASRATRFEAGLLSVDPEGLSELVEGGAFHRPSPAAQPIIPDEVDLMLVAEITRNPFLKLSKLSAERGLSGQVLSYHYVKHVKNARLDNEVRLEAPGETPGKLFEVYTPPGSEERVAWALSNLYYTREALAAPGRGSVYAFTYPQPSEEGALLDLLRRHPLVEDYAFRGYVYAAREYTVPFGGVVGEGGYVLDAMYEALYSRSRKTNFIVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ3</accession>
    <name>A1RYZ3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752688.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1023"/>
    <dbReference type="EnsemblBacteria" id="ABL78423">
        <property type="protein sequence ID" value="ABL78423"/>
        <property type="gene ID" value="Tpen_1023"/>
    </dbReference>
    <dbReference type="GeneID" id="4601638"/>
    <dbReference type="KEGG" id="tpe:Tpen_1023"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OMA" id="PEGYIWP"/>
    <dbReference type="OrthoDB" id="30130at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="5">
        <location>
            <begin position="81"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="315" mass="34677" checksum="460D0B30FCE8C930" modified="2007-02-06" version="1">MPIPIEELGKEEGIGRVTISRLKSAGIETVEDLVLYNPEELEELAGIDFERALRLVRTARRLAGWEVRAVRGDEYASQLSQRESLTTGVKALDELLEGGLVTQEIYEFAGEYGSGKTQLCHQLSVTAQLPPSRGGLGGKVVYVDTEGTFSPSRIERIAERFGVEGALEGVYVARPISVDELEELVIKGLKPLLKGGVKLVVIDSVIALYRAQFRGREWLAMRQQRINYALDWLKRLARVYSIVVVITNQVVSVPSNWGVAVKLPAGGNIIAHASTHRFLMKKAGDSWLIEVLDSPRLPKGATAQFEIRDDGLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ53</accession>
    <name>A1RZ53_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical NADH-plastoquinone oxidoreductase subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752748.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1084"/>
    <dbReference type="EnsemblBacteria" id="ABL78483">
        <property type="protein sequence ID" value="ABL78483"/>
        <property type="gene ID" value="Tpen_1084"/>
    </dbReference>
    <dbReference type="GeneID" id="4601696"/>
    <dbReference type="KEGG" id="tpe:Tpen_1084"/>
    <dbReference type="eggNOG" id="arCOG04654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640061_0_0_2"/>
    <dbReference type="OMA" id="SLVMFRG"/>
    <dbReference type="OrthoDB" id="144102at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="161" mass="16760" checksum="BEC8A6ECAFF39B72" modified="2007-02-06" version="1">MSSLLLVYVLISCAVAVASSLLAVKVKEDFYAAVLLGFVGLSVASLIALLGFTYVAVFHALVYVGATVLFVIMGVIFIGRGLGYERRMLAAGVLTSVFAGSLFYYALQSSAASGSPAPRVGVDLQQLSQAVLQNQVALVFLVFALALLLVAGLPVARGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ61</accession>
    <name>A1RZ61_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">Tpen_1092</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1092"/>
    <dbReference type="TCDB" id="8.A.7.1.6">
        <property type="family name" value="the phosphotransferase system enzyme i (ei) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78491">
        <property type="protein sequence ID" value="ABL78491"/>
        <property type="gene ID" value="Tpen_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1092"/>
    <dbReference type="eggNOG" id="arCOG01113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_7_0_2"/>
    <dbReference type="OMA" id="CNAEWAL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="246"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="14">
        <location>
            <begin position="442"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="13">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABL78491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="566" mass="61699" checksum="74315992ED907A8A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ84</accession>
    <name>A1RZ84_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1116"/>
    <dbReference type="EnsemblBacteria" id="ABL78514">
        <property type="protein sequence ID" value="ABL78514"/>
        <property type="gene ID" value="Tpen_1116"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1116"/>
    <dbReference type="eggNOG" id="arCOG04337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074390_5_1_2"/>
    <dbReference type="OMA" id="DIVIYPS"/>
    <dbReference type="OrthoDB" id="101563at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05126">
        <property type="entry name" value="Mth938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034096">
        <property type="entry name" value="AAMDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="127" mass="14403" checksum="77E7FDA29B09DB80" modified="2007-02-06" version="1">MAYNNDVFVAAGQPLIDAYKFGRLVVGGRAYERDVIITPSGVVPNWWRLEGHRLQLEDVKKYLGLDVDAVVVGTGYHGFMRVDSEVVESFRRMGREVYVLETGRAVEKYNELVARGRRVLAMLHLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ86</accession>
    <name>A1RZ86_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752781.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1118"/>
    <dbReference type="EnsemblBacteria" id="ABL78516">
        <property type="protein sequence ID" value="ABL78516"/>
        <property type="gene ID" value="Tpen_1118"/>
    </dbReference>
    <dbReference type="GeneID" id="4600860"/>
    <dbReference type="KEGG" id="tpe:Tpen_1118"/>
    <dbReference type="eggNOG" id="arCOG01151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803207_0_0_2"/>
    <dbReference type="OrthoDB" id="88711at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="347" mass="38742" checksum="059B6CF9BF31C0C5" modified="2007-02-06" version="1">MWSEELDVEGLKVPVFHLTRDEEVLVFSDVHFGLRFNGRELSLHEELAEFLESVLEGGEHPRLVVLLGDIFELWSASLRDVFSDAFDSLRLLSRLDSTIVFVPGNHDRVTTRLHLESLRGGGGFVIAPEIVLLDIDGKKVLLFHGHQLDGLFLAVKGLWKLQSYVYIFSESLMSLPGPLEWVFAAVAATTVLLLMVLIQATSLLMEAAIALSALILLSPMVILLWRKAQDKIWYGFVQPLASRLLKSRLRGKSLQSLAVSKPLRRLIGFLESFPSVGKLDLVVFGHTHVPEYLAEGGRLILNTGSWVRSNSSTGVDNKTYVRIKNGKVMLAKWEGSEIKIFEASLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ93</accession>
    <name>A1RZ93_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase subunit C</fullName>
            <ecNumber evidence="8">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752788.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1125"/>
    <dbReference type="EnsemblBacteria" id="ABL78523">
        <property type="protein sequence ID" value="ABL78523"/>
        <property type="gene ID" value="Tpen_1125"/>
    </dbReference>
    <dbReference type="GeneID" id="4602020"/>
    <dbReference type="KEGG" id="tpe:Tpen_1125"/>
    <dbReference type="eggNOG" id="arCOG02244">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127125_2_1_2"/>
    <dbReference type="OrthoDB" id="124752at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="127" mass="14104" checksum="6FA12E2A8448A697" modified="2007-02-06" version="1">MERLRVVLSSWFRVKGRSLEHVSFSLRRLSGIVLALYFLVHMVDISTVVLGKEVYDSFLKVFTSPPAVLVDLFLWGVLVVHGVLGAYSAVVESGFLLEKRRQLLAASWLAIVVLFAVGAAVIVNAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA7</accession>
    <name>A1RZA7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin-dependent glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752802.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1139"/>
    <dbReference type="EnsemblBacteria" id="ABL78537">
        <property type="protein sequence ID" value="ABL78537"/>
        <property type="gene ID" value="Tpen_1139"/>
    </dbReference>
    <dbReference type="GeneID" id="4601394"/>
    <dbReference type="KEGG" id="tpe:Tpen_1139"/>
    <dbReference type="eggNOG" id="arCOG00619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592672_0_0_2"/>
    <dbReference type="OMA" id="IWIKLGP"/>
    <dbReference type="OrthoDB" id="14505at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="2">
        <location>
            <begin position="224"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="463" mass="50837" checksum="6017C60CAF5824F0" modified="2007-02-06" version="1">MLEWFALKLGELVLKVKGSLVTLRGISEFMEDYPLDEILLKAIKGSEGVYPFGELATYGAALLGATVHRKGYPRFLTMDDLVLTPPAFTPKRLEKMAELLREPVFTDVNLETSIGGLKSSMPLVVGTMGSTDIASRYSLVIARAAAKEGIPYGIGENVHTIRGYDRRLTRGHPSFKERVMAYLTNIDKYGGVIIQQNVEDAYDEHWNKVYSDKDLEPYLDEGRVAFEIKVGQGAKPGLGGVIKMRKEEAVKVKEKYHFLEDPAEARTAWVERYSAPGTYTADILRGMIRLMKTSYPRAKVWIKVGPFRDVLEVVKVSYEEGADAVIIDGKEGGTGMAPSVAMKELGYPTVVGLAKIRKARLMGVDDRMSLLLAGRLFNGAHIVKARALGATAIYVGRPFIVAAMVKDEAGVRNFIEATRVETQMIVSALGKYSIGDVSPEDVASLNRDLASALGVPYVYSGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC7</accession>
    <name>A1RZC7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroorotase</fullName>
            <shortName evidence="3">DHOase</shortName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrC</name>
        <name evidence="5" type="ordered locus">Tpen_1159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752822.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1159"/>
    <dbReference type="EnsemblBacteria" id="ABL78557">
        <property type="protein sequence ID" value="ABL78557"/>
        <property type="gene ID" value="Tpen_1159"/>
    </dbReference>
    <dbReference type="GeneID" id="4602161"/>
    <dbReference type="KEGG" id="tpe:Tpen_1159"/>
    <dbReference type="eggNOG" id="arCOG00689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="43469at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_A">
        <property type="entry name" value="PyrC_classI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="54"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="431" mass="46832" checksum="7AE12769CDB60EAC" modified="2007-02-06" version="1">MGRAFDLVVTGKAYIGGRVVEASIGVEDGRIAAVSSPALAGSAEERIELGKGYLVLPGMVDIHVHMREPGQEYKEDWRTGSRAAVKGGVTFVADMPNNKPPANTCERLAEKLRRAGEKSLVDFAFYAGFSENPEELLRCPELFVGGKLYPEELFSRSAAYFARLMAKLGKPLVVHAEDPSMFRESRGLPHSYARPPEAELSGVRRALRLCGEAGAWVHVTHVSTGAAVTELLSAKLSGLKATFDVTPHHALLTDSLYSTTLSRIAKVNPPLRGEADRSAVYSALARGLPDALVTDHAPHSPEEKASEDPPPGFPGLELALHLLLSEVLAGRLPLGVIDLYSSRPASLLGVEKGAIAVGMDADLVVVKREEWVVRGDEMVSKARYTPFEGWRLSTKTHAVFVRGRMVYAEGEFFEDARGSLRAPRGAPERWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE4</accession>
    <name>A1RZE4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1176"/>
    <dbReference type="EnsemblBacteria" id="ABL78574">
        <property type="protein sequence ID" value="ABL78574"/>
        <property type="gene ID" value="Tpen_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1176"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="NTYLMYG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="30398" checksum="F1061A597B390644" modified="2007-02-06" version="1">MKIRSLALHMIALAVAVIPLVPLVLLLALAFSESQVDIRGFTLRNFDFLRNGVLFAEDPVYSKLYPNVYTVAFNTFLLALGNMLIVVLISSMAGYIISRYSFKGRSALLGSFLVIHGVPASVLLIALYYMLKSMGLLNTLLGVVLVKVAVDLPLGVWVLKGFYDSIPWDIEIASLVDGSSRLGAFFRVMLPLVKPGIFAVGLFSFLSGWGEYIFVYTFIQSSTNWTFSLLIRSLIGEMGGINLALIAALSIIYLIPVIVIFVVGEKYLVRVTVGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF8</accession>
    <name>A1RZF8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752853.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1190"/>
    <dbReference type="EnsemblBacteria" id="ABL78588">
        <property type="protein sequence ID" value="ABL78588"/>
        <property type="gene ID" value="Tpen_1190"/>
    </dbReference>
    <dbReference type="GeneID" id="4600435"/>
    <dbReference type="KEGG" id="tpe:Tpen_1190"/>
    <dbReference type="eggNOG" id="arCOG10988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340790_0_0_2"/>
    <dbReference type="OMA" id="TTHYDEY"/>
    <dbReference type="OrthoDB" id="100117at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="203" mass="23013" checksum="C075FF5669FDFFD8" modified="2007-02-06" version="1">MALGRRLLSLIVVSCIVLSLRVASGGLTALWVTSTGFYNYDFKSQVVSSSNVDWPVTMVFYGNADVNKVKNIFFGLTILANPMYAYIYSNGWVWDTDRGTKGVVYSNYLNGYVYLHMRVYAPNPPDYIYDPAWGKYVIGTTHYDEYPLESWSGYPEYAEHDFAAIARSKGYTVYQDWAYFYNDQGSPGSITYNDGYATAVYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH5</accession>
    <name>A1RZH5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SufBD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752870.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1207"/>
    <dbReference type="EnsemblBacteria" id="ABL78605">
        <property type="protein sequence ID" value="ABL78605"/>
        <property type="gene ID" value="Tpen_1207"/>
    </dbReference>
    <dbReference type="GeneID" id="4600409"/>
    <dbReference type="KEGG" id="tpe:Tpen_1207"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736928_0_0_2"/>
    <dbReference type="OMA" id="MSHHRED"/>
    <dbReference type="OrthoDB" id="104497at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="364" mass="38743" checksum="473ACFE23A67D40D" modified="2007-02-06" version="1">MKVAYENLPYQHVADSPATKHYANWEVFEEYVARRERASRLGVDAGLLVLRPDVTLSPGTVGVEDEPSWPLPVDTKLPAFHFSNLASSLSLELSGEKLVVAVEKPLEGFYSAHLNVRLRGSSSLILVSLAPPEAAGLSTLSLNVSVEEGSRSRLEVILFDSGSSATALMAVARLGEGSALQESVVAVSGRALYADLKASLRGGGSSLDSSILAVSPREAHASLNTDVAVESPRSSALIRLVGASADGFLAHKGAVKIVRGSVNARGRLSSRLIPLTPSSKVYASPTLEIESDDAEEAQHSASQSPVDPQRIFYLRSRGFTEQEALRLALKAEAFKAFEGRSPNGYVLFYIEEALKAALRSVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH9</accession>
    <name>A1RZH9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[Methylamine--corrinoid protein] Co-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.248</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:26059"/>
            <dbReference type="Rhea" id="RHEA-COMP:11120"/>
            <dbReference type="Rhea" id="RHEA-COMP:11121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:85033"/>
            <dbReference type="ChEBI" id="CHEBI:85035"/>
            <dbReference type="EC" id="2.1.1.248"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; methanogenesis from methylamine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monomethylamine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.248" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752874.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1211"/>
    <dbReference type="EnsemblBacteria" id="ABL78609">
        <property type="protein sequence ID" value="ABL78609"/>
        <property type="gene ID" value="Tpen_1211"/>
    </dbReference>
    <dbReference type="GeneID" id="4600413"/>
    <dbReference type="KEGG" id="tpe:Tpen_1211"/>
    <dbReference type="eggNOG" id="arCOG05143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047925_0_0_2"/>
    <dbReference type="OMA" id="QDKTTGM"/>
    <dbReference type="OrthoDB" id="48486at2157"/>
    <dbReference type="UniPathway" id="UPA00643"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043852">
        <property type="term" value="F:monomethylamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008031">
        <property type="entry name" value="MtmB_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036655">
        <property type="entry name" value="MtmB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05369">
        <property type="entry name" value="MtmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75098">
        <property type="entry name" value="SSF75098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="447" mass="47672" checksum="EAB71B4AF3434DEB" modified="2007-02-06" version="1">MRGPLLVELRARKGEYVEQKRFDLERVSRRVAELEKEYGVSFDPSSPAPSEDLAKPVFEAGFTLAVETGLYVVDESRVARFTEEEVREALRNAPRELRVGRGKDERVLRARGPGDRVFVFGGLAGTPVPLEFFEASAASYAAVPRVDALDHGSIQAVAGEAVRGYAPSEALAGIEEAEGVRRALRAVGRPGMHVLGAESSVSSVGSLSALSLGLLGEGDAQLLPVLNELKTDYGQLTKAYVGLARGLIGAALVDPVVGGYARGPAGSAIVSVAETLLALVAYEAGYFLVHPVHILRKATSTLECMWVESVVGLANRYMGLPVVADIWPANGGGTREYLYEAAANTFVAVASGLNVLGPVPANGTQPNGGGFESWFVASLADLVAEKKVSVGAAWSAALELYEKYADKLSSPNPGKPFWELYDLKSLKPSAEWEKTVWEVLREVAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI0</accession>
    <name>A1RZI0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monomethylamine corrinoid protein</fullName>
            <ecNumber evidence="3">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1212"/>
    <dbReference type="EnsemblBacteria" id="ABL78610">
        <property type="protein sequence ID" value="ABL78610"/>
        <property type="gene ID" value="Tpen_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1212"/>
    <dbReference type="eggNOG" id="arCOG02028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082102_2_0_2"/>
    <dbReference type="OMA" id="AKKFVQG"/>
    <dbReference type="OrthoDB" id="95903at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="92"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="224" mass="24293" checksum="F89184CE47740716" modified="2007-02-06" version="1">MDCRGVYAEISRRLADLDAGTVERLVSEALEAGCDVVEVVEEGLRKGMVEVGVRFERGEYFLPELVEAGDIFNSVMEKYVLPRLKGSRAGVRGRVVIGTVRGDIHDIGKNLVATMLRVNGFEVVDLGVDVPPERFVEAVEKYGAEVVGMSALLTTTMLEMRNVIDALKAAGLRDKVKVIVGGAPVTEEIAREIGADAYGRDAVDAVEKCAKLVEELRRARASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK6</accession>
    <name>A1RZK6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752901.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1238"/>
    <dbReference type="EnsemblBacteria" id="ABL78636">
        <property type="protein sequence ID" value="ABL78636"/>
        <property type="gene ID" value="Tpen_1238"/>
    </dbReference>
    <dbReference type="GeneID" id="4601170"/>
    <dbReference type="KEGG" id="tpe:Tpen_1238"/>
    <dbReference type="eggNOG" id="arCOG14787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140618_0_0_2"/>
    <dbReference type="OrthoDB" id="74403at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="246" mass="28525" checksum="1D2258AA430CB393" modified="2007-02-06" version="1">MVAGKPSKLVFDDFLEKSEYWKYRVDNYAGFELGNSVLRLWMGPTEALYYSNAELSDGAFDELPWSRAVFEAKIRMSGLHYGSAGWGFWNHTMVFQTCMPMWFIHLQSRGPYPFQGFFAQVRNHFAPIKVYRGSLLPYSVATRLLGGLPGVVVHTHKPSMQHLDLTQWHVYRVEWGASEVRFYVDGVLAARLPNKGYESRARADIWIDNAVFGYNPRDAGQVYRHLTQENRSRTFLEVDYVKVYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK9</accession>
    <name>A1RZK9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752904.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1241"/>
    <dbReference type="EnsemblBacteria" id="ABL78639">
        <property type="protein sequence ID" value="ABL78639"/>
        <property type="gene ID" value="Tpen_1241"/>
    </dbReference>
    <dbReference type="GeneID" id="4600536"/>
    <dbReference type="KEGG" id="tpe:Tpen_1241"/>
    <dbReference type="eggNOG" id="arCOG08882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_0_0_2"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="101400at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="147" mass="16016" checksum="16B9DAB334050D22" modified="2007-02-06" version="1">MKVAFGADDNYSIARFVVEELKRRGHEVVLVGSPLTGKPYPWPKVAVEVAELVASGKVDTGIVMCYTGTGVSIAANKVKGVRAALCTDAKNARGARLWNDANVLALSARLLSEEVAKEILDEWFSVEKPDPSELENIEFVKKLDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL2</accession>
    <name>A1RZL2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752907.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1244"/>
    <dbReference type="EnsemblBacteria" id="ABL78642">
        <property type="protein sequence ID" value="ABL78642"/>
        <property type="gene ID" value="Tpen_1244"/>
    </dbReference>
    <dbReference type="GeneID" id="4600539"/>
    <dbReference type="KEGG" id="tpe:Tpen_1244"/>
    <dbReference type="eggNOG" id="arCOG12287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192673_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="232" mass="24428" checksum="0746099CD10EC839" modified="2007-02-06" version="1">MPVGLDASLVEERSEVDYCGWEAGRLEEALRSDPLLGRVIGHAEWELLVSGSWRSMGFTGCVALLRLAGRVEVEGVFADFLRGASYSARVVAGGLHVFYDRGRGRVVLLDPLLGGGEGLRADSGELARVLEFAGRLWGEAGEARLVGEYSYGQLGSLRVYEVLTAGGAALVGVEPGGRIVERFTGLAVPGRRATFPPTSRGRGRPGRGLSAGLQSCPPGACHSTTTTSSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM6</accession>
    <name>A1RZM6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formate dehydrogenase family accessory protein FdhD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1258"/>
    <dbReference type="EnsemblBacteria" id="ABL78656">
        <property type="protein sequence ID" value="ABL78656"/>
        <property type="gene ID" value="Tpen_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1258"/>
    <dbReference type="eggNOG" id="arCOG04358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056887_4_2_2"/>
    <dbReference type="OMA" id="APEDAIC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="224" mass="23873" checksum="5A4D9C5EC8BE1736" modified="2007-02-06" version="1">MDREAYCLRNGRLERCVDRVVVERAYAVYVNGSRLVSLSCSPGMEEELALGFLAGLGFSPSRGYSVSVEGGRVEVRGELERAPWRRGWGKFPAEVVVRAVERLAELGEGFRATGALHGALCFTPGGEVVGFVEDVSRHCAVDKCLGLAVKRGLDLGSLGFAVTCRLTGSVVEKFVSASVPLVASKAAVTLQGVLAAERGGVTLVGFARGGRFNVYTYPKRIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN2</accession>
    <name>A1RZN2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752927.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1264"/>
    <dbReference type="EnsemblBacteria" id="ABL78662">
        <property type="protein sequence ID" value="ABL78662"/>
        <property type="gene ID" value="Tpen_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="4600479"/>
    <dbReference type="KEGG" id="tpe:Tpen_1264"/>
    <dbReference type="eggNOG" id="arCOG07460">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275255_0_0_2"/>
    <dbReference type="OMA" id="DKKRYWR"/>
    <dbReference type="OrthoDB" id="122114at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="235" mass="26028" checksum="B4B30981D58CA5A3" modified="2007-02-06" version="1">MFSRYAALVKNLRGVVLLDPSEEGAKESLRWLAERFRYRNLGLTPAAAASLGSPQKPFRVLAYPLEEYERFAGELAGCAGLEKGLTELLVLSSLYVSPAILVGYRYREALGAVAVDEVRVRGAMGVQQWKLHLRIADYTVLDMYEYSVETAEEAVRSCGDEAKVASLLEERARRVAADKKRYWRVSSGEGDVFMYYVDNLRVYCSRCGSSGLCGRDWLAAALAVVPVVVVPPGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP0</accession>
    <name>A1RZP0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, MJ1666 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752935.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1272"/>
    <dbReference type="EnsemblBacteria" id="ABL78670">
        <property type="protein sequence ID" value="ABL78670"/>
        <property type="gene ID" value="Tpen_1272"/>
    </dbReference>
    <dbReference type="GeneID" id="4600739"/>
    <dbReference type="KEGG" id="tpe:Tpen_1272"/>
    <dbReference type="eggNOG" id="arCOG03433">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528556_0_0_2"/>
    <dbReference type="OMA" id="HEIYWEN"/>
    <dbReference type="OrthoDB" id="110543at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013383">
        <property type="entry name" value="CRISPR-assoc_prot_DxTHG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010171">
        <property type="entry name" value="CRISPR_Csx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019016">
        <property type="entry name" value="Csx1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09455">
        <property type="entry name" value="Cas_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01897">
        <property type="entry name" value="cas_MJ1666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02549">
        <property type="entry name" value="CRISPR_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="454" mass="49562" checksum="8EA4B11D0B255187" modified="2007-02-06" version="1">MGCRALLLATWGNPAQWNTARYELGGESDESFTSLGILCRHLSKSGCEARALVLVLESLLDAKLDKEPDGKRPGYAYLYERREELARLRGLLLEGRYGEAVEGLRSVVEGLAKSAGAGCSGGVAVEVLPAIGSFGGGVRFAGDVRNFHSFALLAAAREVLRGGPAPSKIVVDLTHGVNFMPTYAYEVAREAASLSLLAGSRSVEMEVYNSDPYPPGSEKPSLSLNLVRREEVREIRLPSEAGSLVEWRGGRPPSRFEEFRARASRFMGEKVYPVVASLYYPLPLALVYLASAQSWEEYLGVVEEARSLWASYTRVSGGTVERPVYVNPQAVYAALLAAAACKAVREEGLSNDVESLEKLNERVYRRVSEVHYALIAQELSQVEAGRFEEAAYPRKPDKRIMIAHAGLQKGFVRVERGEKKLLLYVGADGKPLKPEDPSAAESVRSLLAKAGLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP3</accession>
    <name>A1RZP3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752938.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1275"/>
    <dbReference type="EnsemblBacteria" id="ABL78673">
        <property type="protein sequence ID" value="ABL78673"/>
        <property type="gene ID" value="Tpen_1275"/>
    </dbReference>
    <dbReference type="GeneID" id="4600742"/>
    <dbReference type="KEGG" id="tpe:Tpen_1275"/>
    <dbReference type="HOGENOM" id="CLU_2079548_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3883" evidence="2">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="14195" checksum="5F0FA7AC06946FDC" modified="2007-02-06" version="1">MIKYEELHGRRAQNVSSEKKGYDIESKDREGNTRYIEVKKRDLKYGFVFLTHNEFMNFLRNENSWLYIVYKENGETRVIEISREKVLKHAKPELKWRVSLRKEVTGRRARNQRQDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR0</accession>
    <name>A1RZR0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752955.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1292"/>
    <dbReference type="EnsemblBacteria" id="ABL78690">
        <property type="protein sequence ID" value="ABL78690"/>
        <property type="gene ID" value="Tpen_1292"/>
    </dbReference>
    <dbReference type="GeneID" id="4600600"/>
    <dbReference type="KEGG" id="tpe:Tpen_1292"/>
    <dbReference type="eggNOG" id="arCOG06024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_856912_0_0_2"/>
    <dbReference type="OMA" id="GLEYWAT"/>
    <dbReference type="OrthoDB" id="76959at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="324" mass="35037" checksum="A4E6CE8D4ECAD596" modified="2007-02-06" version="1">MLYEARLVLRSPAIVVERRTERGYVKPLGYIPGSTLRGAILDALRAEGVLSLDDLRREAESPSVLSSPAYPLVGGKRALPASPFAAYCRECGVVYDFAPVYARQGKLESIKCPVGRDHTLKPAYPGIVVYKRVAEGGVVVAEKAPIRTFRSTSVGVSKRRGAFERGMLFDYEAVAEGTEFWAYVWAPFDLPGRLEVTVGRGASRGFGWAELTLKAAGSAPFSASGLFVALSPLVPLKKASWGDCTLEVERVLGRTYRVLAGWDSFKRSPLPVVELVRQGALVEGRVSCNRDPRAGIPVRLGGYWLTGVNAVVPFGEYLRGGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR6</accession>
    <name>A1RZR6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752961.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78696">
        <property type="protein sequence ID" value="ABL78696"/>
        <property type="gene ID" value="Tpen_1298"/>
    </dbReference>
    <dbReference type="GeneID" id="4600652"/>
    <dbReference type="KEGG" id="tpe:Tpen_1298"/>
    <dbReference type="eggNOG" id="arCOG02914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456828_0_0_2"/>
    <dbReference type="OrthoDB" id="136617at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="597" mass="64375" checksum="C3B704D29FA58B34" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW6</accession>
    <name>A1RZW6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1349"/>
    <dbReference type="EnsemblBacteria" id="ABL78746">
        <property type="protein sequence ID" value="ABL78746"/>
        <property type="gene ID" value="Tpen_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1349"/>
    <dbReference type="eggNOG" id="arCOG01900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_6_0_2"/>
    <dbReference type="OMA" id="QAKTYYG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="280" mass="32144" checksum="117559E1E092DE25" modified="2007-02-06" version="1">MLVRLGVSTYSYWHFEGPRLPLREYLRRAYEDGFAGVEVLVDHVESRARSYLKEVRRFAFEHGLEIYAVALHNNFVRPDPAEREAEVKRVVEWLNVAYELGADVVRVDSGRWGTVKSFDELMARRGVEPPLEGYSEDDAVEWVVDCLYRCLDAAEELGVIVGLENHWGLTTRAETMLKIVRRVSSRWFGVVMDTGNFVHDTYSELEAIAPYAVMVHAKTYFGGGVWYTLDLDYGRIFGMLRRHGFKGWVSLEYEGREDYSSGVRKSRELLMRYVGGGTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX9</accession>
    <name>A1RZX9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated RAMP protein, Csm5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753024.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1362"/>
    <dbReference type="EnsemblBacteria" id="ABL78759">
        <property type="protein sequence ID" value="ABL78759"/>
        <property type="gene ID" value="Tpen_1362"/>
    </dbReference>
    <dbReference type="GeneID" id="4602199"/>
    <dbReference type="KEGG" id="tpe:Tpen_1362"/>
    <dbReference type="eggNOG" id="arCOG03719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810424_0_0_2"/>
    <dbReference type="OMA" id="YCKADEA"/>
    <dbReference type="OrthoDB" id="13356at183924"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="368" mass="39569" checksum="983C293710C62ACC" modified="2007-02-06" version="1">MRRLTLKVEVVTPVHVWDGYERVYGLDVVAVDGQACVADFERLRPDALRGEPPAGLAEFAERVARWVREGALPCSRRVGMRAQPRVGDAVRLLPPTLVPASSLKGYLRTALLFRLLRRVAEERGSEEAAKLLRGTVNTRGDPRRAGEALENALLRVPRLRRQGGYADAMQSVVVSEPRASGCASSLSKLSVVEASGKAVGELVVEVLEGGSLEYEVLFPEPPPVNLASAGGLEGELKAIAGLLASPSPEELARALEEFGSALLEHEVERLRGARESLAKAGYDVATYLGRLEGLRGGGCAVARLGFATGHASKTLALLVKRLDPELYKEVADAMSRRLGRTWDELTFKLVDVGGAYLGAGWVKVCVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ1</accession>
    <name>A1RZZ1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1374"/>
    <dbReference type="EnsemblBacteria" id="ABL78771">
        <property type="protein sequence ID" value="ABL78771"/>
        <property type="gene ID" value="Tpen_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1374"/>
    <dbReference type="eggNOG" id="arCOG01293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862275_0_0_2"/>
    <dbReference type="OMA" id="YPHHAVL"/>
    <dbReference type="OrthoDB" id="109301at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="313" mass="34143" checksum="D415D0760FEC8C74" modified="2007-02-06" version="1">MVIGSGLSGLALADSLRGVEVEVYEVRREPGGFFARDDYPVDGVRGSELVSRLLAGRKVRTGVAAFRLDEGGAWFLGEEGAFRAEGRVVLATGFRERTAVELGVYGCRPAGVFPLTAAWDFANMGYSVGDRVLIYGFNHYTLSLASRLVKVCDKVVILYREPSLVHSVDEALRLGVEVERGRVRRVEGRDRVELVKTDSSELRVDALVLGELAPWNPLGGRLLAGNAFMVIESPLKLVESSRLLAELLEAGGELRRVEGGVPAFPGYVSEKHRRVMLGVGRGARVRLGDRIVTTEEPYQVVELPPGKPRVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S010</accession>
    <name>A1S010_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753055.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1393"/>
    <dbReference type="EnsemblBacteria" id="ABL78790">
        <property type="protein sequence ID" value="ABL78790"/>
        <property type="gene ID" value="Tpen_1393"/>
    </dbReference>
    <dbReference type="GeneID" id="4600676"/>
    <dbReference type="KEGG" id="tpe:Tpen_1393"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699467_0_0_2"/>
    <dbReference type="OrthoDB" id="115550at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="394" mass="43042" checksum="A501544A44549C8F" modified="2007-02-06" version="1">MEGAALRVSEEILASVERRVEELAEKIEGSPFKSAGFVDGSNVVDERRGAYVAVFSVASIVLDSGRLRPVSHGSRHPLVARIVPKGFGEQRANLYMSILELLSAARLVRSGVEAVFLDGSYVSEMMVVFGYPRDVYEEAQGLVDREAAESYAGEAAGLVEEALGSEGVKGAAKLFEGVSGLAWRLYTRLGGGVGGVEKRVLLDYSYVFAEVAVYLEALRSLLTAGRESGVPLFWVAKDADTDQLAEKEGVGGWLNDVTLLDYAWRRLEGVYTVLEGREFGRPKPCAAPGKLVEELFAKWRRYRVAYFKLRLHGPVLQMTFPGYVGEDEAREALATLSSLAESRGYPKPLSYVHNMAVLNPELARLVGDELYKRAESPVLKAMLAPSGRVQAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S027</accession>
    <name>A1S027_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate dehydrogenase, cytochrome b556 subunit (Formate dehydrogenase gamma subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753072.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1410"/>
    <dbReference type="EnsemblBacteria" id="ABL78807">
        <property type="protein sequence ID" value="ABL78807"/>
        <property type="gene ID" value="Tpen_1410"/>
    </dbReference>
    <dbReference type="GeneID" id="4601824"/>
    <dbReference type="KEGG" id="tpe:Tpen_1410"/>
    <dbReference type="eggNOG" id="arCOG05636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154403_0_0_2"/>
    <dbReference type="OMA" id="KHMPKFL"/>
    <dbReference type="OrthoDB" id="85673at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="26543" checksum="5D9069EE2BBDA408" modified="2007-02-06" version="1">MGVGRRVEIISKSYRIAHTHNLHFIAILSVTGLTVMALEYFSWLAYVVGLPFAPLLGVDPVTAGVQIFRVLHRIFGVAWGGLLVVYGCYLFCSGKARVFDPLKKPLRDQLKEASSLAKHYLLGKPIPEEVLEKMERHNVFVSYLAILLGVGFALLAVSGVGLMLRYALGLTAQQAAILLFLHDLGFGITVLFVLFHLFAAFHPSNRPLLDAMFGNGTAPFDWVAEHMKAYVKRYGVAPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H5</accession>
    <name>A1S0H5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1560"/>
    <dbReference type="EnsemblBacteria" id="ABL78955">
        <property type="protein sequence ID" value="ABL78955"/>
        <property type="gene ID" value="Tpen_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1560"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="QGNGAGH"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="344" mass="37095" checksum="819E1BD969505365" modified="2007-02-06" version="1">MAPSSMGEGVGRSSCIVVRGVSKVFSGGVRALDGVSMVVEEGEIHAVLGPNGAGKTTLMRVLTTQIKPSSGDAWVLGRHVVKEAARVREVIGYVPQEFSVWTDLTGYENAMIYAKLYGVPPSERRRVVEDMLEFMGLGEAKHRLVKTYSGGMIRRLELGIALMTKPRVLFLDEPTIGLDPRARELVWSRILEYAGEGGVTVVFNTHYMDEAERFAGKVTVMNRGRVIAEGAPRELVEKAGGGATVKIEFDGELEKALGALSGVRGVEVVSAGNPVVLRVEDLEVQVAGVFRALLGNGVNVKKVSLQPPSLEDVFLRLTGMTFEEAERSSLREVAATRKAIGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z8</accession>
    <name>A1S0Z8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753393.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1733"/>
    <dbReference type="EnsemblBacteria" id="ABL79128">
        <property type="protein sequence ID" value="ABL79128"/>
        <property type="gene ID" value="Tpen_1733"/>
    </dbReference>
    <dbReference type="GeneID" id="4601758"/>
    <dbReference type="KEGG" id="tpe:Tpen_1733"/>
    <dbReference type="HOGENOM" id="CLU_2340340_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="97" mass="10550" checksum="B84766F13A555B9B" modified="2007-02-06" version="1">MREEELKSYRENVTRLQEDVKSLQVKLSSAQTDLSALKAQVSSLEAQLSESRSRLAEAEARAQLVGVAGTVVGLVVGFAIGYFVSRKRLGKPEASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S148</accession>
    <name>A1S148_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753443.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79178">
        <property type="protein sequence ID" value="ABL79178"/>
        <property type="gene ID" value="Tpen_1783"/>
    </dbReference>
    <dbReference type="GeneID" id="4601927"/>
    <dbReference type="KEGG" id="tpe:Tpen_1783"/>
    <dbReference type="HOGENOM" id="CLU_1173418_0_0_2"/>
    <dbReference type="OrthoDB" id="129298at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="236" mass="24353" checksum="928812F219341AE5" modified="2007-02-06" version="1">MGLVDAKPILAVGLLVAATLLLVALAWYDVESRTAPLPRVNPTPQPRQPPAGAEQGPETGGEPRNASLPSTSGSTAGQGGTAPVAGNLTGGGSPCPSCNVSAPGNWSPGAWRVIYALKIIVTGGPESNASAVPVLGNLSVEVVSVDRSGYQGSCVATMKQRTEGGVAYVDVTIPVSMDKCYSIKPRLVKASPSEVVYELDPVEDPGGFCHGCAKFTLKISYLPPGSYQSCLVPYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S157</accession>
    <name>A1S157_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-cone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_1792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753452.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1792"/>
    <dbReference type="EnsemblBacteria" id="ABL79187">
        <property type="protein sequence ID" value="ABL79187"/>
        <property type="gene ID" value="Tpen_1792"/>
    </dbReference>
    <dbReference type="GeneID" id="4601915"/>
    <dbReference type="KEGG" id="tpe:Tpen_1792"/>
    <dbReference type="eggNOG" id="arCOG03714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406518_0_0_2"/>
    <dbReference type="OMA" id="EEWYRNW"/>
    <dbReference type="OrthoDB" id="117297at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ATP-cone" evidence="8">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL79187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10913" checksum="26732B36C8ABB8C8" modified="2007-02-06" version="1">MTIYVVKRDGRKEEFAYEKIVVSCLKAGAPLEVARKIAKIVEGDLLKRKVSEVTTKDLMKEVLALLKEENEEWYRNWIIFDRAVKRRATEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S161</accession>
    <name>A1S161_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic molybdate-binding protein/domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1796"/>
    <dbReference type="EnsemblBacteria" id="ABL79191">
        <property type="protein sequence ID" value="ABL79191"/>
        <property type="gene ID" value="Tpen_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1796"/>
    <dbReference type="eggNOG" id="arCOG00230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064037_1_0_2"/>
    <dbReference type="OMA" id="IRMINRE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="289" mass="31871" checksum="07AC8AB9F9748DEF" modified="2007-02-06" version="1">MSNLERRLGVQLVRRTRGGLGGGRVMLTATAQLLVERFRVAERKASRMRLGEALGAELRIYGSDCPGVEVAASLLEERGVFAEYLRVGSIAGLDLLKRGYCHLAGVHVVDPETGRYNEVVVREGLALIRGYWREIGFMVLPGNPKNIYSPADLLRRNVVLANRNRGSGSYVLLEKLLKDLSSSLGVPVQALKRRIRGFETEYISHGEAGLAVLNGKADVAIGPRWTARQLGLDFVPLAKERFDFATRRELLKDENVETFVEVLRSKEFAEKAASVGLAVDEETGKVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S194</accession>
    <name>A1S194_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753489.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1829"/>
    <dbReference type="EnsemblBacteria" id="ABL79224">
        <property type="protein sequence ID" value="ABL79224"/>
        <property type="gene ID" value="Tpen_1829"/>
    </dbReference>
    <dbReference type="GeneID" id="4602066"/>
    <dbReference type="KEGG" id="tpe:Tpen_1829"/>
    <dbReference type="eggNOG" id="arCOG00665">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_2"/>
    <dbReference type="OMA" id="KRYDVGN"/>
    <dbReference type="OrthoDB" id="78828at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="34009" checksum="A2548C715CE655C3" modified="2007-02-06" version="1">MPSLSKGVLLAAGLGTRLVPYSKEMPKEMLPVFFGVNNSVYLKPVIQAVFEQFYEAGIREFCFVVGRGKRVIEDHFTPDWDFVEYLEKTGKNDYAELLRDFYEKVEKSYITWVNQPVPRGTGHAVYMAKGFVGDDYFMAAATDNLFLGENIPRRLLEYFDRLRSPMLAVKRVRDPRRYGVVIGSRVDTSIYRVEGIVEKPREPLSYLANTSLYIFPPEIFRAIEQTTPSPRGELEVTDSIQILIRSGYQFYAYEAEADWIDIGTWETFLRAALVSLKHALGADKLSEILSELGIGAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B1</accession>
    <name>A1S1B1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1846"/>
    <dbReference type="EnsemblBacteria" id="ABL79241">
        <property type="protein sequence ID" value="ABL79241"/>
        <property type="gene ID" value="Tpen_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1846"/>
    <dbReference type="HOGENOM" id="CLU_2010219_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="123" mass="13843" checksum="AE74DA34DAB83448" modified="2007-02-06" version="1">MNRKASVPMLGGCIVVHQVYPPSKSVGGKGEAVYFLKCPGGFVEVHEHVTVIRPKGEEEFGYVFRSETEGWYGPGARVLSWVPLWHYLDDITDGKFKKKVHTPEELYSLVEEAYAQWEAEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C7</accession>
    <name>A1S1C7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751382.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1862"/>
    <dbReference type="EnsemblBacteria" id="ABL79257">
        <property type="protein sequence ID" value="ABL79257"/>
        <property type="gene ID" value="Tpen_1862"/>
    </dbReference>
    <dbReference type="GeneID" id="4600334"/>
    <dbReference type="KEGG" id="tpe:Tpen_1862"/>
    <dbReference type="eggNOG" id="arCOG13910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745641_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="149" mass="16827" checksum="E629FC59BEAD8CE7" modified="2007-02-06" version="1">MARKPRSQIVCPRCGAPGSIERFYSNGRAYLRVRHSLGGGKRSYCYIGPADSYVHVELLHALTLTNLVNTDPAQVAERALEELISSARFVHGKKDLEGWVARAKLAVDAVEIALEKLKRVLEEKEAELEALRREEERELLRQNGLLVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E4</accession>
    <name>A1S1E4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1879"/>
    <dbReference type="EnsemblBacteria" id="ABL79274">
        <property type="protein sequence ID" value="ABL79274"/>
        <property type="gene ID" value="Tpen_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1879"/>
    <dbReference type="HOGENOM" id="CLU_1136108_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="244" mass="28323" checksum="212816D84A7E0818" modified="2007-02-06" version="1">MCYPHVVVNPYVYYDWEQWLKKCRPEGVLVDTGVHKVFKESGGFEYPSGFEYGYARFISRVHAQARVEEFYYVIPDYPSDYPGMEQFYPLNVEKTLESIKRWLTRVDSLPGTAVAVVQGKKDDPLSPVRVYSENRELYDEFELVALGPTCASNRWGVLAKMILAFDSVTAKPFHVFGPSLRAVARVAGRTRRFFSFDSSAMYRWCENSWCSDIEERAEAIRAYISRYEEIARRWGSQPSILSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW58</accession>
    <name>A1RW58_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Tpen_0028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751703.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0028"/>
    <dbReference type="EnsemblBacteria" id="ABL77438">
        <property type="protein sequence ID" value="ABL77438"/>
        <property type="gene ID" value="Tpen_0028"/>
    </dbReference>
    <dbReference type="GeneID" id="4601384"/>
    <dbReference type="KEGG" id="tpe:Tpen_0028"/>
    <dbReference type="eggNOG" id="arCOG02730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153004_0_0_2"/>
    <dbReference type="OMA" id="SIVVHEY"/>
    <dbReference type="OrthoDB" id="115360at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="139" mass="15917" checksum="35FCD8524B44A9BF" modified="2007-02-06" version="1">MGDVTRIVVDTDILLHDTFEDSEKHAEASELLDEADRIYLASIVVHEYLWLLLTKFKIDIDSVREKLEEYFSDARFIYISENSEVFMGALDLMKEDKADPSMINDYIILVLAQRMGATLATYDEELREIAKKLGVPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW63</accession>
    <name>A1RW63_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0033"/>
    <dbReference type="EnsemblBacteria" id="ABL77443">
        <property type="protein sequence ID" value="ABL77443"/>
        <property type="gene ID" value="Tpen_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0033"/>
    <dbReference type="eggNOG" id="arCOG00022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140805_0_0_2"/>
    <dbReference type="OMA" id="WKDSPWH"/>
    <dbReference type="OrthoDB" id="114082at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="124" mass="14707" checksum="FCA810F8DFEA5F5C" modified="2007-02-06" version="1">MIKSILGSIANDSRKHAEIYSGILRILREVGPAITEEDFSRLEGIVKTHIRMEEEMIETLNRFFKEVDDKRVEYLFRYILDDEVKHHRLLLNILELIVKREVVTEKDIWDFIWREVPFHGTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW65</accession>
    <name>A1RW65_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0035"/>
    <dbReference type="EnsemblBacteria" id="ABL77445">
        <property type="protein sequence ID" value="ABL77445"/>
        <property type="gene ID" value="Tpen_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0035"/>
    <dbReference type="HOGENOM" id="CLU_830603_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="40597" checksum="8E42D007CFE7733F" modified="2007-02-06" version="1">MPVVALLEGWYASIARSGEAFRLTPNEWKVLVSVVNSTTVSRVSEQAKLPYSTVIDVMRRLSGNGLGIHFIPYFDLAGLRKVFALIEGAPISGYPLYTTNVYRLIGRGFFTGVLGLVPDYLVNEFFASLPREPVATVVGDEYRHWAPTGRLTRYVAAHGIVVPAYDQLEDVLYASRGPVTRREKKWVDWVDVLIVYFKMKYAFTKLSDVYSLAKSVFGTAPPSRQLMSYHYRTHVSPLWSYNGVSFRIDRHLAPERVYVLRGNASKVAARTLIEAPFFFEALVNEESSVLLAQTPCYMSPLVYRVLAETRVDLPYGELLVAESWSFEWLTSDAVKHYRDHNEWLHPSVSVRMLPPDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW69</accession>
    <name>A1RW69_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77449">
        <property type="protein sequence ID" value="ABL77449"/>
        <property type="gene ID" value="Tpen_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0039"/>
    <dbReference type="eggNOG" id="arCOG14515">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149115_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="144" mass="15355" checksum="2B52FE0624E7C355" modified="2007-02-06" version="1">MSSHVTMRGLLVRGVTALAIVLALMYLFSTSLYIPVPVYKGVSVGNIVVAVLSIVFLIKAESLATPLASEVALHLKLQPGRVGGVAKWALRLLSLLVLYGGFFGVAVPVFDVFLEHHVSRVVYDSVFVVAAAVTVYELVKSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW76</accession>
    <name>A1RW76_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751721.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0046"/>
    <dbReference type="EnsemblBacteria" id="ABL77456">
        <property type="protein sequence ID" value="ABL77456"/>
        <property type="gene ID" value="Tpen_0046"/>
    </dbReference>
    <dbReference type="GeneID" id="4600416"/>
    <dbReference type="KEGG" id="tpe:Tpen_0046"/>
    <dbReference type="eggNOG" id="arCOG04410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071520_1_0_2"/>
    <dbReference type="OMA" id="FLLKAKC"/>
    <dbReference type="OrthoDB" id="78551at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014444">
        <property type="entry name" value="PH1575-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006593">
        <property type="entry name" value="UCP006593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="32594" checksum="1FA43B1ABE3E8899" modified="2007-02-06" version="1">MRIHPECVLCIYRTRAGEVLASNLSDEAKVEALGKLTVFYGGLVEPSSSTVVLAWKAFRKVKELLGAEDPYRYFKEQSHAAAMSVVERLAARAEGLEGYERFKYFLSLSVAANLVDPGSPMGVSPEQLLEKASSLRFARDETDRLYLTLLQSSRVTYLLDNCGEAVFDGLVLRELRRMGIQLKIVAKGAPYQNDVTHDDALRMGFQELGEVVSTGSDFPGVVPGYVSEEAVKALEWADVVISKGMANFEAFLMSPPKTAVFVAFVAKCRPIAQAARVNPGDAVAAFLRYPQGLRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA0</accession>
    <name>A1RWA0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751745.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0070"/>
    <dbReference type="EnsemblBacteria" id="ABL77480">
        <property type="protein sequence ID" value="ABL77480"/>
        <property type="gene ID" value="Tpen_0070"/>
    </dbReference>
    <dbReference type="GeneID" id="4601778"/>
    <dbReference type="KEGG" id="tpe:Tpen_0070"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_1_0_2"/>
    <dbReference type="OMA" id="YLIEERT"/>
    <dbReference type="OrthoDB" id="52091at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="124"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="354" mass="39681" checksum="5A46205AAB39E2AA" modified="2007-02-06" version="1">MSERVPGEAGGGTPRDNAIQLLKLLGLTGLEAELYLLLLEKGPLSAPEISDYLVKHRPQIHVALTRLSSKGYIEELGGRPKKYRAVDPQLLLNLFLKDFDSLAKKALSYMRGLSKPSLEEKFGVWIIREPEVAKSRIAELLDSATIDALIMGDIKFLHMLSDKIEAAVERGVRVYVLSYSLGERGAKFIVEDMPFLKKLRVAISGDLVVVVDSERGGVLKARPTLPIRHGYLIEERTLTDYLSHDFMNRWVSSKVIVDENYDMPLKFTFHRMALYETKKLLLENKKLRLKATGYEIDTGARVEVSGRIVDAVLDLPAGYAHFKVETDSGVIRVGGLDAIVEEIAGEYFEIYEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA3</accession>
    <name>A1RWA3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0073"/>
    <dbReference type="EnsemblBacteria" id="ABL77483">
        <property type="protein sequence ID" value="ABL77483"/>
        <property type="gene ID" value="Tpen_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0073"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777602_0_0_2"/>
    <dbReference type="OMA" id="FCGGRCL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023819">
        <property type="entry name" value="Pep-mod_rSAM_AF0577"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273:SF2">
        <property type="entry name" value="PTHR43273:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01104">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04084">
        <property type="entry name" value="rSAM_AF0577"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="356" mass="40769" checksum="2034699F2AA1C6E9" modified="2007-02-06" version="1">MLYIVHTTGQCNLKCDYCGGSFDPRKVPWSVKYDYHLLKKLVERDEDSIVAFYGGEPLLNKDFVKWVLENVRAKHFVIQTNGTLVKSLPERYWHMFDAVLLSVDGRESVTDKHRGSGVYRRVVESARWLREIGFKGDLIARMTVTEDTDIYEDVKHLLSLGLFSHVHWQLDVVWSDRWKCFSCWRDGNYLPGVAKLVKEWLEEMRRGKVLGIAPFKALITRAFHKSYSAPPCGAGVSSFSILTDGRIVACPIAVEERWALVGRVEDGEIHPERAPKISEPCSSCRYFEFCGGRCLYAYMERLWGEDGFREVCVATQRFIDIVLSTLNEVKELLSAGVVSMSDIYYPPFNNTVEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA4</accession>
    <name>A1RWA4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0074"/>
    <dbReference type="EnsemblBacteria" id="ABL77484">
        <property type="protein sequence ID" value="ABL77484"/>
        <property type="gene ID" value="Tpen_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0074"/>
    <dbReference type="HOGENOM" id="CLU_1145264_0_0_2"/>
    <dbReference type="OrthoDB" id="137765at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="26488" checksum="8B92364325AE91A1" modified="2007-02-06" version="1">MNVKNILVGLFLIFVLLQILEAYLYNTLDAGYLEVTDVDFSGNVENLTLRIYLSNPYSVPLQFQEVSVKAKCGSSFYGASRGNVTVPPASHSVLQLEVGIPFGEEACNFTLVEYPMLLVTRLTGITFINKSKQFQLAIPGYGARFLWAGWNKTSVKLGECVDIEVHVKPPGPYRLTVLAELTGFAPEAVAQYEGLGDGVFTFCPKEPSSFKLKGYFLQVSAQDATWTQAPGYPPRLRVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB0</accession>
    <name>A1RWB0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751755.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0080"/>
    <dbReference type="EnsemblBacteria" id="ABL77490">
        <property type="protein sequence ID" value="ABL77490"/>
        <property type="gene ID" value="Tpen_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="4600810"/>
    <dbReference type="KEGG" id="tpe:Tpen_0080"/>
    <dbReference type="eggNOG" id="arCOG06769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_2"/>
    <dbReference type="OMA" id="IQACPRD"/>
    <dbReference type="OrthoDB" id="105722at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19455" checksum="6B63DFFE9C34ACE1" modified="2007-02-06" version="1">MIATVKISLCGPGGVGKTSLARKFVEGSYNPQERLTVGIQHFFRKIQLDGRELHVVIWDLGGEHRFRFLAPAFLKGAKGVVYVFDLTREETFLEIDEWRKITESVLGKVPSILIGNKADLEEYRIVPYNLAREYALSKGFLEYFEVSARTGARVEEAFLFLLRTIVQSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF1</accession>
    <name>A1RWF1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751796.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0121"/>
    <dbReference type="EnsemblBacteria" id="ABL77531">
        <property type="protein sequence ID" value="ABL77531"/>
        <property type="gene ID" value="Tpen_0121"/>
    </dbReference>
    <dbReference type="GeneID" id="4601200"/>
    <dbReference type="KEGG" id="tpe:Tpen_0121"/>
    <dbReference type="eggNOG" id="arCOG01005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067263_0_0_2"/>
    <dbReference type="OMA" id="YLPERWY"/>
    <dbReference type="OrthoDB" id="59250at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="300" mass="32425" checksum="D1F8030BA0D83CD9" modified="2007-02-06" version="1">MSRRSLALVAVVVLVALGIGYLLLSPGLSPQAPRAGGLKIVVTFYSLKGDIEYLLCQGDEVIPVTPQGVDPHEYQLTPSDVARIREGSLIVSTAHAPFEQKIKQLVETGELKSRLIEIPRIPGIKLLVNPSTGTLNYHWPIYDPNNYIAYINYTAHVMASLRPECASTYLSKASGLIANITSIERSAPRLNLVAVGSSPVVQYSVEWMGINVSYLLIKEADLPATPQDIATIEDAMARGAINVVVISKGLETTSAGKTLVDLASKYGKPVLYVPSPISSESTYEKILVVVKEVEKVLQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI1</accession>
    <name>A1RWI1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751826.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0151"/>
    <dbReference type="EnsemblBacteria" id="ABL77561">
        <property type="protein sequence ID" value="ABL77561"/>
        <property type="gene ID" value="Tpen_0151"/>
    </dbReference>
    <dbReference type="GeneID" id="4600643"/>
    <dbReference type="KEGG" id="tpe:Tpen_0151"/>
    <dbReference type="eggNOG" id="arCOG02559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578249_0_0_2"/>
    <dbReference type="OrthoDB" id="134932at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="472" mass="50427" checksum="CEB4959CBAA0AA17" modified="2007-02-06" version="1">MSRLRIAALLISAALLLLLVPSLGAPAKVNLLTAHFDRDCVFLGGSLKVGAYSLPFFGYVSNSTRKLYYVDAPGFVTGSYATNGSGVFVGTVFLEGAPSILVAEVEPRGEPRVYALRSAVPLYGVDVVSLGNGTLFVAGYVYAEATTRSSDVVVVRLSKGTPVRVVVFGSPSFDDHPRRILYAGGYLVVVGETWAYNVSQGDVFVARLTPQLELKDDTVVGGAGIDTPEDALPLDDGSLLLVGSTVGGDGTHDGFVARVSEVGGLLYLSSITGYGEEYAVAVTRVGGAYVVVAYGGFEEDTSGALILNYTLRGAWDLAFQGAYLVKASNSSVLPVKAPWGAREAVFKTDGEVFEVFSGREVCLSNNCSLREVVLAEYGKQVSAMLSPIYGWRTLHGVMKARATPEVEALALDYRGALLNASTSSLEVFIQPYARRFDPVKETIKFLERNIPILLFLPMVAAAVIVTLQIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ9</accession>
    <name>A1RWJ9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase U62, modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751844.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0169"/>
    <dbReference type="EnsemblBacteria" id="ABL77579">
        <property type="protein sequence ID" value="ABL77579"/>
        <property type="gene ID" value="Tpen_0169"/>
    </dbReference>
    <dbReference type="GeneID" id="4601424"/>
    <dbReference type="KEGG" id="tpe:Tpen_0169"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_1_2"/>
    <dbReference type="OMA" id="TCLWYIR"/>
    <dbReference type="OrthoDB" id="49762at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="2">
        <location>
            <begin position="119"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="220"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="445" mass="49476" checksum="5B0D645D4476EB8E" modified="2007-02-06" version="1">MAESLIEIGEKIKNYALRAGFEEVAVLLYRRESVMVKFANGEPSVTQNWTDHAADIYLAKGGKILGTSAPTHSLEEIYRVIDSLHQMQERLPPSMLYAPLPEPEKHEPLPGLVDKRIVEAIEDPAHVSEAVVEAANRYKVDSFAGMLQLTYEVKALVNSKGASFSEDSTYVKTYIRSFAGEGSGQWSLGSRRLSISDVEKVAETASHLAYQSRRQEDYPPGRTNVLLSPMVAGNFLNYIVEMATASSIMMGFSIFMNRKPGEKVSSELLTVEDAPRLAELPGSTSFDDEGIRTYTKPVIEKGVLRNVLHNSKTASKLGGKTTGNAGLVFPRVWNINVHPGDYTFEELLAEMKEGLVVTNNWYTRLQNYIEGTFSTILRDAILIVRNGEIVGAAKKLRIADSFPRILENIVALGKETYDMYWWEVETPTRTPYILVKDVGTSSHTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ3</accession>
    <name>RL1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl1</name>
        <name type="ordered locus">Tpen_0223</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751898.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWQ3"/>
    <dbReference type="SMR" id="A1RWQ3"/>
    <dbReference type="STRING" id="368408.Tpen_0223"/>
    <dbReference type="EnsemblBacteria" id="ABL77633">
        <property type="protein sequence ID" value="ABL77633"/>
        <property type="gene ID" value="Tpen_0223"/>
    </dbReference>
    <dbReference type="GeneID" id="4601213"/>
    <dbReference type="KEGG" id="tpe:Tpen_0223"/>
    <dbReference type="eggNOG" id="arCOG04289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="70269at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000308156" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="225" mass="24913" checksum="09366C620B39854E" modified="2007-02-06" version="1">MSSQTLVAAGSLEEAIKEALVSSPKKRRFTQSVEMIVTLRDVDVKKPENRLNTVVALPHPAPGKLAKVAVIASGDTALKAKEAGADIVVDKDELQKIGNDKKAAKKLAKRYDFFLAQPDLMPLVGRVLGKYLGPRGKMPQPIPPNVALDALIERFRRSVRIRMKDEPQIACRIGVETQPVEHLAENARAVLAEILKKFPPPNIDRIYFKLTMGRPVKVSREVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS3</accession>
    <name>A1RWS3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="11" type="ordered locus">Tpen_0243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751918.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0243"/>
    <dbReference type="EnsemblBacteria" id="ABL77653">
        <property type="protein sequence ID" value="ABL77653"/>
        <property type="gene ID" value="Tpen_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="4601470"/>
    <dbReference type="KEGG" id="tpe:Tpen_0243"/>
    <dbReference type="eggNOG" id="arCOG04093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="OrthoDB" id="89943at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="KOW_RPS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RS4NT" evidence="10">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S4e" evidence="8">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="251" mass="28333" checksum="9FD8F12BD4FE1A0D" modified="2007-02-06" version="1">MGRKVKGSLRHLRRSVAPPFWPIKRKEYVWTVKPSPGPHSLLSSIPIGIVLRDVFGYAKTMKEARRILASRVIEVDGRVVTDYKFPVGLMDVLHIIPEEKYYRVVPDPARKLRFVEIKPEEAGYKLAQIRRKMTVKNGDLQFTLHDGRNVLIRKGSEAYSTAISYKTYDALLITIPRQSIVSHVPFEVGTLAIVVDGRNVGFMGRINAIQQVFKRSRALVELEDASGAKSRTILQYVLPVGKEKPLVTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS8</accession>
    <name>A1RWS8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0248"/>
    <dbReference type="EnsemblBacteria" id="ABL77658">
        <property type="protein sequence ID" value="ABL77658"/>
        <property type="gene ID" value="Tpen_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0248"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="OMA" id="DIYNAMW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="150"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="366" mass="39960" checksum="37F8662276C87D5F" modified="2007-02-06" version="1">MIDFKQHVSKVVERILVPNDLNYLVVMSASNIFYLSGSDAPSALVVSKEGEVSALASRLEYFRAVSETSGLRVVAFAREGEDVSEYEEVVRGDFYEALSRMVSGSERIGVVGASCEAKEKLAEKTGKQLYDYSKEFSLIRRVKDPGELEAINRAARLAELAMRKALDTLEPGVTESEVASEILKVIVSSGAYPSFPPIVAFGEHAAHPHAKPSLRRLIKGDFVKIDLGAKVDGYCSDMTRTLVFGEPSEKQRRIFEAVVKAQESALASIKAGVQAREVHAIALRALKEAGLSQYFNHGLGHGVGVDIHEEPYLNLQSEAVLLEGDVVTVEPGVYLPGYGGVRIEDMVYVERGGGRLLTFFSKDMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU3</accession>
    <name>A1RWU3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">o-succinylbenzoate synthase</fullName>
            <shortName evidence="3">OSB synthase</shortName>
            <shortName evidence="3">OSBS</shortName>
            <ecNumber evidence="2 3">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menC</name>
        <name evidence="5" type="ordered locus">Tpen_0263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2 3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751938.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0263"/>
    <dbReference type="EnsemblBacteria" id="ABL77673">
        <property type="protein sequence ID" value="ABL77673"/>
        <property type="gene ID" value="Tpen_0263"/>
    </dbReference>
    <dbReference type="GeneID" id="4601681"/>
    <dbReference type="KEGG" id="tpe:Tpen_0263"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_4_2"/>
    <dbReference type="OMA" id="CRIINIK"/>
    <dbReference type="OrthoDB" id="62994at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01933">
        <property type="entry name" value="MenC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01928">
        <property type="entry name" value="menC_lowGC/arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="370" mass="41773" checksum="060068AED9CAFA8A" modified="2007-02-06" version="1">MEIRKLELFYLEMKLKEEFRTSFGSVSTRPVVLVRVEEKGGEEGWGELVADRGPWYSYETYETSSLVIRKFIAPSLVGRDIEEVEDFHRLVASIRGYPMAKTAVEEALLDLEARMEGRSVSEVLGGSRQEIEAGVSIGIKASVEELLREVRRRLEEGYQRIKVKIKPGYDVEVVKRIREEFGDIRLQVDANGAYSLRDIGVFRELDRFNLLMLEQPLAYDDLYEHSVLSRKISTPVCLDESIRSLHDLVVASILGSAEVVNVKPARVGGVLKAKSILEVAAKLGWGAWVGGMLETGIGRAFLVALASLPFVNYPNDISASNRYWDEDIVEPPWEITPRGTIAVPRRRGLGVEVKRELVDRLSLERWTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV9</accession>
    <name>A1RWV9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18e</name>
        <name evidence="4" type="ordered locus">Tpen_0279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751954.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0279"/>
    <dbReference type="EnsemblBacteria" id="ABL77689">
        <property type="protein sequence ID" value="ABL77689"/>
        <property type="gene ID" value="Tpen_0279"/>
    </dbReference>
    <dbReference type="GeneID" id="4602089"/>
    <dbReference type="KEGG" id="tpe:Tpen_0279"/>
    <dbReference type="eggNOG" id="arCOG00780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146465_0_0_2"/>
    <dbReference type="OMA" id="WRLERPR"/>
    <dbReference type="OrthoDB" id="104254at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="13804" checksum="47863D0558C6C684" modified="2007-02-06" version="1">MKRTGPTNIHLRLLIHKLRKYSRLYKAPVWRDVAEYLERPRRKRVEVNLSRIDRHIKEGDVVVVPGKVLGGGSITKSNVVIAAWRFSRSALERLDGRVKAISIEELLEQNPEGKNVKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY4</accession>
    <name>A1RWY4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="5">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0304"/>
    <dbReference type="EnsemblBacteria" id="ABL77714">
        <property type="protein sequence ID" value="ABL77714"/>
        <property type="gene ID" value="Tpen_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0304"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="WINPPDF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="216"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="489"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="732" mass="81852" checksum="784520C8C56E8C65" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX33</accession>
    <name>PUS10_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine 54/55 synthase</fullName>
            <shortName evidence="1">Psi54/55 synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pus10</name>
        <name type="ordered locus">Tpen_0354</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX33"/>
    <dbReference type="SMR" id="A1RX33"/>
    <dbReference type="STRING" id="368408.Tpen_0354"/>
    <dbReference type="EnsemblBacteria" id="ABL77763">
        <property type="protein sequence ID" value="ABL77763"/>
        <property type="gene ID" value="Tpen_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0354"/>
    <dbReference type="eggNOG" id="arCOG01015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_2"/>
    <dbReference type="OMA" id="DGGLYIK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01893">
        <property type="entry name" value="Pus10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005912">
        <property type="entry name" value="Pus10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000407397" description="tRNA pseudouridine synthase Pus10">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01893"/>
        </source>
    </evidence>
    <sequence length="444" mass="50205" checksum="9867C6736B3B0F2F" modified="2007-02-06" version="1">MSTGTSASYKRDNAFYALDKVERILLDGYSLCDACTGRLFGLRGYGLSNTERGRALKTLLIMKAFQASPRQADLELLRVLARTGFEPARELLKKLSGEDVEVKACSICEGLTGRYYELALRAVEEAKSYEFNTFEVGVRIDAEVIRREEELWRRYGLESAESIRNEASREVGKIISKLTGKEYSRNNSELLIIVDLSAGAIELHPAPVFVYGRYRKYARGLPQNPWPQPDERIKFNTSIEELIVKPALELFEAEKAKFHAAGREDIDVRTLGTGRPFVLEIKKPRKRNIDLKVLAEKINSGAGGLIEVLDLAYTDRKTIKKLKSLASIAKKAYVARVKFEKPVDDEKLAEISKVFSNAVINQRTPTRVLHRRVDKLRKKIVYRLEARKISQDEVEFYLETQGGFYVKEFIHGDNGRTTPSIAEFLGNNVLSIELDVVSIEETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX47</accession>
    <name>A1RX47_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ordered locus">Tpen_0368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752042.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0368"/>
    <dbReference type="EnsemblBacteria" id="ABL77777">
        <property type="protein sequence ID" value="ABL77777"/>
        <property type="gene ID" value="Tpen_0368"/>
    </dbReference>
    <dbReference type="GeneID" id="4600768"/>
    <dbReference type="KEGG" id="tpe:Tpen_0368"/>
    <dbReference type="eggNOG" id="arCOG04249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044679_1_0_2"/>
    <dbReference type="OMA" id="DVDLVPC"/>
    <dbReference type="OrthoDB" id="82755at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="44"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="467" mass="52711" checksum="D9DD7BBEB1C817B2" modified="2007-02-06" version="1">MTCRDPCVFKYPECLEEVLKKVKPSAEDKRALDLFAERLMAVVLEEANTRAGGEVSVELHGSYRHDTWLKGEADIDLFLLFPKKYSLEEMKEVARRVSEGSSARLGARVEERYASHPYYTLVFPNSVEVDVVPAYRVFSPSEIVTPVDRTQLHTAYLERKLSEKPWLKDEIRLLKRLLKNLGIYGAEQSLKGFSGYLAEILVVYYDGLEKLLREAARWRPGKVAVPDGKDLLERFKGQPLVVLDPVDSRRNAAASVSLDSLSKFILAAKMFSEDENILCCLLDPPEPRVDPDEELPRLLSSHNVIAVLARRHPELPGDALLGKMQRIGKSLEGYLAGLGFKVLRFKATLLSGTPALLVELESLTSPKTVLHVGPPVWHPNAGNFLRKWSTKSYGPFVSNGRLAVIRNVVSEEISEHVLSLLKSYAGFSWEVKDLRNILRDLSAEEKKEVYRWLSSVEPWTICAQYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX67</accession>
    <name>A1RX67_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase P/RNase MRP subunit p30-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752062.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0388"/>
    <dbReference type="EnsemblBacteria" id="ABL77797">
        <property type="protein sequence ID" value="ABL77797"/>
        <property type="gene ID" value="Tpen_0388"/>
    </dbReference>
    <dbReference type="GeneID" id="4600523"/>
    <dbReference type="KEGG" id="tpe:Tpen_0388"/>
    <dbReference type="eggNOG" id="arCOG00307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084245_0_0_2"/>
    <dbReference type="OrthoDB" id="125732at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="259" mass="29423" checksum="B62319136082899F" modified="2007-02-06" version="1">MKHRRFLDVYASELPLEGVASLRDDELLSLFREIYARARKAGYHGCVFVARVGNQEWSLYREAKRFDETARKLRESGIECYSRCHLQISAQSLLKKALRMLRPLFDVISVEAETRAITAFGSRDHRVDLITLPQRNIPEILKGDIDEILKQGKFVEITLDRFFLGGSKPLDVAQVARVRETVKPLVDKGVGIVISSGPSSPYSPRDPRAVISFGEVFLGIKYENLSRWMSDALRSRIAENIYKRVGKIPARGVRYADVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX93</accession>
    <name>A1RX93_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ordered locus">Tpen_0414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752088.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0414"/>
    <dbReference type="EnsemblBacteria" id="ABL77823">
        <property type="protein sequence ID" value="ABL77823"/>
        <property type="gene ID" value="Tpen_0414"/>
    </dbReference>
    <dbReference type="GeneID" id="4600490"/>
    <dbReference type="KEGG" id="tpe:Tpen_0414"/>
    <dbReference type="eggNOG" id="arCOG04077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199467_0_0_2"/>
    <dbReference type="OMA" id="VCRECHR"/>
    <dbReference type="OrthoDB" id="119723at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="7597" checksum="B2482424CF8DBE6B" modified="2007-02-06" version="1">MPAKRRLPLKACVKCKALVEDSVDVCPVCGSREFTDDWDGFVAVIDPEKSEAAKLLSLKQKGAYSVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC7</accession>
    <name>A1RXC7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps24e</name>
        <name evidence="5" type="ordered locus">Tpen_0448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752122.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0448"/>
    <dbReference type="EnsemblBacteria" id="ABL77857">
        <property type="protein sequence ID" value="ABL77857"/>
        <property type="gene ID" value="Tpen_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="4601871"/>
    <dbReference type="KEGG" id="tpe:Tpen_0448"/>
    <dbReference type="eggNOG" id="arCOG04182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_3_2_2"/>
    <dbReference type="OMA" id="HETAKIY"/>
    <dbReference type="OrthoDB" id="124805at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="106" mass="11903" checksum="0BEACBB78240054F" modified="2007-02-06" version="1">MAVSSLRIIQEKVNKLVGRRELLVEIHHQGSGTPSRRDVAEALRNMLGTGGSAIVVRKLVTRYGQGVSEALIHIYDSDVKMKMFEPKHILRRNGLIQEQEAKKQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE3</accession>
    <name>A1RXE3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752138.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0464"/>
    <dbReference type="EnsemblBacteria" id="ABL77873">
        <property type="protein sequence ID" value="ABL77873"/>
        <property type="gene ID" value="Tpen_0464"/>
    </dbReference>
    <dbReference type="GeneID" id="4600991"/>
    <dbReference type="KEGG" id="tpe:Tpen_0464"/>
    <dbReference type="eggNOG" id="arCOG00932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053467_0_0_2"/>
    <dbReference type="OMA" id="DCFYCPL"/>
    <dbReference type="OrthoDB" id="85003at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040087">
        <property type="entry name" value="MJ0021-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43288:SF1">
        <property type="entry name" value="PTHR43288:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01108">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="39850" checksum="1083960B19522E41" modified="2007-02-06" version="1">MKRVRTLKSGSVVYGKLPRGCTLCQQGLKTVIFLTGLCPYNCFYCPLSNYRKQRDVTFVNEVEVYDPGEYFTLLKAEILRSGSLGASLTGGDPLVKQSLSVETAKFLKEVFGKGFHIHVYTTGLLLRHETLNSLVEAGLDELRIHAPLDRLEEVLNVASEWGDKLSIGLEYPALPRSEDSLVRLLEVAERYELDFVNLNQLEFTETNSVSLELRGYRLSEDYRSAEGSAEAALKAVSYAEEKRLNISVHYCPVKVKDHYQTGLRLYRLAVLSAATHQYVTDDGTLVEVSYDELASGNEHVASLYADKFIHPMLVDKVKKGKVLERNPALRKLVLEETPIREEREHGENAFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE4</accession>
    <name>A1RXE4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752139.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0465"/>
    <dbReference type="EnsemblBacteria" id="ABL77874">
        <property type="protein sequence ID" value="ABL77874"/>
        <property type="gene ID" value="Tpen_0465"/>
    </dbReference>
    <dbReference type="GeneID" id="4600993"/>
    <dbReference type="KEGG" id="tpe:Tpen_0465"/>
    <dbReference type="eggNOG" id="arCOG05650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860796_0_0_2"/>
    <dbReference type="OrthoDB" id="129414at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="137" mass="16150" checksum="16A5ED742C4D2D9D" modified="2007-02-06" version="1">MLRTRILRSVGVYVVEKDREVFWLDLRVSGFRQSKRVESFLPYFNFLRKWLVENGLIRDLDEGENHVLRFSKDPESPEVTVLVILLKRGNRVSKAIISPLKPGLLRLIDERLRGAGWRSVFLVDMKTRTRVREREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE6</accession>
    <name>A1RXE6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Adenine-57, 58-N(1)-) methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752141.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0467"/>
    <dbReference type="EnsemblBacteria" id="ABL77876">
        <property type="protein sequence ID" value="ABL77876"/>
        <property type="gene ID" value="Tpen_0467"/>
    </dbReference>
    <dbReference type="GeneID" id="4600995"/>
    <dbReference type="KEGG" id="tpe:Tpen_0467"/>
    <dbReference type="eggNOG" id="arCOG00978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_2"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="OrthoDB" id="64860at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="255" mass="28503" checksum="CFC8CF8191D71768" modified="2007-02-06" version="1">MSECVKTGDWVLLYHDEKHRYTVKVEEGRVYHTTHGSVNLTEVVGKRYGETVRTNIGEDLVVSRANLLDRLGSLRRFTQVIYPKDAAYIVVSANIGPGSRVVEAGTGTGFLTAILAWYVRPSGRVYTYEIRKDFYEAALENLKEVGLLPYVEAKNKDIRKGIDESDVDAVVLDMPDPWNVAEEAYNALTHGGILAVFVPTVTQLERVIVAVRKSGFKVIEPVEVNVRKYKPVPGELRPETLGVLHTGYLLTARKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH2</accession>
    <name>RS28_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps28e</name>
        <name type="ordered locus">Tpen_0495</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752167.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXH2"/>
    <dbReference type="SMR" id="A1RXH2"/>
    <dbReference type="STRING" id="368408.Tpen_0495"/>
    <dbReference type="PRIDE" id="A1RXH2"/>
    <dbReference type="EnsemblBacteria" id="ABL77902">
        <property type="protein sequence ID" value="ABL77902"/>
        <property type="gene ID" value="Tpen_0495"/>
    </dbReference>
    <dbReference type="GeneID" id="4601329"/>
    <dbReference type="KEGG" id="tpe:Tpen_0495"/>
    <dbReference type="eggNOG" id="arCOG04314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_2_1_2"/>
    <dbReference type="OMA" id="MHGEASQ"/>
    <dbReference type="OrthoDB" id="121548at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_S28e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000004125" description="30S ribosomal protein S28e">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <sequence length="77" mass="8514" checksum="1DC1759B8F3D2ACE" modified="2007-02-06" version="1">MSSQAPADKFSDAVPAEVVQIIGRTGITGEVTQVRVRVLEGRDKGRILTRNVRGPVRVGDIVMLRETEREARKIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL2</accession>
    <name>A1RXL2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide binding protein, PINc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752207.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0536"/>
    <dbReference type="EnsemblBacteria" id="ABL77942">
        <property type="protein sequence ID" value="ABL77942"/>
        <property type="gene ID" value="Tpen_0536"/>
    </dbReference>
    <dbReference type="GeneID" id="4601049"/>
    <dbReference type="KEGG" id="tpe:Tpen_0536"/>
    <dbReference type="eggNOG" id="arCOG04116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023387_0_0_2"/>
    <dbReference type="OMA" id="FADMRMA"/>
    <dbReference type="OrthoDB" id="19750at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="530" mass="59359" checksum="B9E2A5C76E095CF7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL6</accession>
    <name>A1RXL6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/ketoisovalerate oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752211.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0540"/>
    <dbReference type="EnsemblBacteria" id="ABL77946">
        <property type="protein sequence ID" value="ABL77946"/>
        <property type="gene ID" value="Tpen_0540"/>
    </dbReference>
    <dbReference type="GeneID" id="4601054"/>
    <dbReference type="KEGG" id="tpe:Tpen_0540"/>
    <dbReference type="eggNOG" id="arCOG01603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_2_0_2"/>
    <dbReference type="OMA" id="KWGQAIP"/>
    <dbReference type="OrthoDB" id="107581at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="185" mass="19384" checksum="49596492E68F6F26" modified="2007-02-06" version="1">MNESVDVVWLGRGGQGAVTAASLLAQAAVLRGKYALAIPFFGAERRGAPVFAYTRIADGTILSRARVKRGDILAVLDPSLLGQVNVESLLKPGGRIVINTGGRRIEVGARGEAYCVDAVSIADSLGLRLAGIVLVNMPMVGAVGRVYGGVGLPDLESAVKEVIKVHVERNVEAVKRGWEGVGHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM9</accession>
    <name>A1RXM9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752224.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0553"/>
    <dbReference type="EnsemblBacteria" id="ABL77959">
        <property type="protein sequence ID" value="ABL77959"/>
        <property type="gene ID" value="Tpen_0553"/>
    </dbReference>
    <dbReference type="GeneID" id="4600517"/>
    <dbReference type="KEGG" id="tpe:Tpen_0553"/>
    <dbReference type="eggNOG" id="arCOG03746">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2271183_0_0_2"/>
    <dbReference type="OrthoDB" id="115916at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="123" mass="14153" checksum="D86311C69022CFA0" modified="2007-02-06" version="1">MVQVPVYRDYNEFSVRVVQALLEMIRHTRGSIITFNAKKVAVFAGIDTQPVVLTLVKDVLERLREKDYVVVLGKTKHGVKYAVKKDTPLWVLAKSYEKVVIRNLEDLNMILEKVQQARTALRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN7</accession>
    <name>FAU1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable ribonuclease FAU-1</fullName>
            <ecNumber evidence="1">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA-binding protein FAU-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fau-1</name>
        <name type="ordered locus">Tpen_0561</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAU-1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752232.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXN7"/>
    <dbReference type="STRING" id="368408.Tpen_0561"/>
    <dbReference type="EnsemblBacteria" id="ABL77967">
        <property type="protein sequence ID" value="ABL77967"/>
        <property type="gene ID" value="Tpen_0561"/>
    </dbReference>
    <dbReference type="GeneID" id="4600604"/>
    <dbReference type="KEGG" id="tpe:Tpen_0561"/>
    <dbReference type="eggNOG" id="arCOG04307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044303_0_0_2"/>
    <dbReference type="OMA" id="GTYVNVC"/>
    <dbReference type="OrthoDB" id="83570at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01910">
        <property type="entry name" value="RNA_binding_AU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016730">
        <property type="entry name" value="RNA-bd_FAU-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000334214" description="Probable ribonuclease FAU-1">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01910"/>
        </source>
    </evidence>
    <sequence length="491" mass="54025" checksum="E29B5317C99C0A40" modified="2007-02-06" version="1">MIRVRGIHSTAIAGLLDEAGFRFADLSQELLARIPQLRVEERVLVTVKDTDDRSGVVVLGDRAVVEKVAYLLRAVIPGALVSYVGEGPYTTYAVRLLSRVEGDVYEAEYSPGKRTTVKLRRPHVEGEVIMAHVIRASPEAPLLKEGVAITGSLVRLVQFDRHSVSEHIRDENLRLQLLTLAMTSAPTGWGVHFRSASKRASIVDVMAEIKALSEKAEKILKEVAPKEPGVVVPGEAIAIVEIPADASIRMDALRSRYYPTLPLHHLLKRLGDDELSRAVDFSERLLAGCEKCLSSTGAIEVFLERLSSLKGRQVSVLHRKVAGAGHVWSAEVESVKRMTVVLKRVVSSPGLYDGFEGLKREPGDVIRSYTWLFGRAVVHFYTSARGELKGVYVNINAPVFFAGNANTLGYVDLGVDVTRAADEEPKVVDLAEFLDLVERGVLDKQLAGSYLEFAESVKHLLEKDIGEDLPARIMQAQKSIFSFETDKLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP2</accession>
    <name>A1RXP2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752237.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77972">
        <property type="protein sequence ID" value="ABL77972"/>
        <property type="gene ID" value="Tpen_0567"/>
    </dbReference>
    <dbReference type="GeneID" id="4600610"/>
    <dbReference type="KEGG" id="tpe:Tpen_0567"/>
    <dbReference type="eggNOG" id="arCOG00653">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565932_0_0_2"/>
    <dbReference type="OMA" id="KKPYPHN"/>
    <dbReference type="OrthoDB" id="120096at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="84" mass="9531" checksum="686B77310CE5B26E" modified="2007-02-06" version="1">MSKKPYPHNDDIVEAILEVLGKDFTVSPEEFPSRVKEKLEEKGFYAGLVSEKRVWSLYEKLVKSGRMPDYLGVVPAGEERSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ1</accession>
    <name>A1RXQ1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752246.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0576"/>
    <dbReference type="EnsemblBacteria" id="ABL77981">
        <property type="protein sequence ID" value="ABL77981"/>
        <property type="gene ID" value="Tpen_0576"/>
    </dbReference>
    <dbReference type="GeneID" id="4600620"/>
    <dbReference type="KEGG" id="tpe:Tpen_0576"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="EWLLTHY"/>
    <dbReference type="OrthoDB" id="90722at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="180" mass="20914" checksum="33603CCADFD92D9B" modified="2007-02-06" version="1">MAWRCRRALFMGRFQPFHLGHYNALKWIVERESEVVLAIGSAQYSHSLRNPFTVGERLEMVYAVLREEGLLDRVLVTVVPDTDGQHSLWVKLVVSFSPCFDVVYTNDPLSRMLFEEEGFKVESIPFYEREKYEGTRIRRLMAEGGDWAQYVPPAVAEVIRRIHGEQRVRSLFYLEAGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR5</accession>
    <name>A1RXR5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752260.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0590"/>
    <dbReference type="EnsemblBacteria" id="ABL77995">
        <property type="protein sequence ID" value="ABL77995"/>
        <property type="gene ID" value="Tpen_0590"/>
    </dbReference>
    <dbReference type="GeneID" id="4600632"/>
    <dbReference type="KEGG" id="tpe:Tpen_0590"/>
    <dbReference type="eggNOG" id="arCOG06056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269991_0_0_2"/>
    <dbReference type="OrthoDB" id="137037at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="232" mass="26310" checksum="B1EAEB46F214ED10" modified="2007-02-06" version="1">MYGNFEREWLRRLARAYAFWKKFWDDLLPKPENPLTRIVFTLPKKEEESIDEIARKLEEAGHGDFVRALLAEKKPRVLLGFLYYAGPIGEAVYGVYRYASSHVKCSNVVVEDFSADALTVSDAIAKWKADKIVVFTAKKRGRKPALYAYSLVLRKPREWEAVEAIRPSLEGSLDIDDLLRGLSVFLPGTTIHVYECEPAENEPDTCEKSLIDAVIGEVSHECISEDPNNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV4</accession>
    <name>A1RXV4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid binding, OB-fold, tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0630"/>
    <dbReference type="EnsemblBacteria" id="ABL78034">
        <property type="protein sequence ID" value="ABL78034"/>
        <property type="gene ID" value="Tpen_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0630"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560982_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="486" mass="54757" checksum="2E6E252970A9050E" modified="2007-02-06" version="1">MLLIGYFGIALETRMDEYSWHETPPEEILIEEILRHKRNLTREDLERLIREKIEDFGGVIKREAAVYLLAKEMGINFLREFLPASLTALRVRDLAVGLRNVDVEGVVVSMYPLSVTSGGKQYLRFALADREAIIWSVAWGEKALELSGMLTVGKKVLVKAVSVKKYREKNELIIDKNSSVEVLGDVSFDELLRIAKTHSLRLHALSVVHVAKESGRIFLYGFDEECNPAVAVLPVLDRFSLEITPGSTLLLDNCGRSTVGEYNYLVCRENSNVLKVQRRDGCSDTHASRFYLEGYVLGFEIFRREGGRVYLLVNGKPEPLVLFRDSLLSSLAALSARKARIWGLRRTDGTLREAPFTQVEALGEQLQLQVVKGKKLLECSGLLEATLTLVSADLRFRCIDGRPLYTVYLVFDDGTATIRAVSNSPQILEEVYELQESDLCELESSVIEKIKTYRVERIGGLEYATKIFVNKFSPKTGFVFSLRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY29</accession>
    <name>A1RY29_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0707"/>
    <dbReference type="EnsemblBacteria" id="ABL78109">
        <property type="protein sequence ID" value="ABL78109"/>
        <property type="gene ID" value="Tpen_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0707"/>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130237_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="134" mass="15028" checksum="C58C2F98576FA019" modified="2007-02-06" version="1">MCSQCAKGKTVIGVLTFSQGAPSKPRTAVTRRRRGGEVEEIIVENYGEIIRSARERMGWTRDVLAAMVGEKESTIRRIEAGQLEPTIDLARKLEKVLKVKLIEELTDYGDYSEDYGYEGVTLGDIAEFRDRGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY95</accession>
    <name>A1RY95_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pgk</name>
        <name evidence="10" type="ordered locus">Tpen_0773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0773"/>
    <dbReference type="EnsemblBacteria" id="ABL78175">
        <property type="protein sequence ID" value="ABL78175"/>
        <property type="gene ID" value="Tpen_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0773"/>
    <dbReference type="eggNOG" id="arCOG00496">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_2"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="409" mass="44347" checksum="EC5A0C1870307E9F" modified="2007-02-06" version="1">MIEGLGIKTLDDVDVRGKTVGVRVDFNSPVDPQTKRLLDDTRIRAHAETTIRELVEKKAKVVVLSHQGRKGDPDFTSLREHAEVLSRLVPARVKFVDDIFGEKAVKEIKALSPGEVLVLENVRMWDGEAKNASPEEHAKTPLVQALAPLLEVYVVDAFSAAHRPHASLVGFAPVVKHFVAGRVMERELQALYRVRNNPERPCVYVIGGAKAEDTAEIISSVLGNNIADKVLTGGLAANLLLHSSGKKIGDVNVSVLKEKGFLDLEPELKKLLDKYGDRIVLPVDLAVEESGKRVEVGVDSVPNLPIKDIGSRTAEEYARIISEARTVVMNGPMGVFEDEKFSLGTKKVFEAMASSKAFTLIGGGHTIAAASKLGFADKLSHVSTGGGALIEYLIKGTLPVIEVLKKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA1</accession>
    <name>A1RYA1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752446.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0779"/>
    <dbReference type="EnsemblBacteria" id="ABL78181">
        <property type="protein sequence ID" value="ABL78181"/>
        <property type="gene ID" value="Tpen_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="58786996"/>
    <dbReference type="KEGG" id="tpe:Tpen_0779"/>
    <dbReference type="HOGENOM" id="CLU_1029045_0_0_2"/>
    <dbReference type="OrthoDB" id="134170at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="292" mass="32173" checksum="ADEEE688D918B847" modified="2007-02-06" version="1">MSVEVRYGREGCPEDSFQVLPSCEERPGVVAPDHVLALALREDGFVRSHHAVAFLLRTAPGPNTVAKAAAVSPEGWRELLYLSMHVEDQPSSSRCACLLPFAPSTSTLAALGKSEVCLDASSLGAVFLASFVHVALSMGARRIILLNPPYLDYWERLKLSGLPGYRRALIERMPRALRVRAAVDINVDLSKNEIYEKVPFSFKLPQPRKPPSLLRFAFQEKEGLALELLREVEASGLVTSYKAFLEAARELNPGEGVAVARRLFLYGYVSIRQGQVEATEKAIYALGAGWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB8</accession>
    <name>A1RYB8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted aconitase subunit 1</fullName>
            <ecNumber evidence="2">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752463.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0796"/>
    <dbReference type="EnsemblBacteria" id="ABL78198">
        <property type="protein sequence ID" value="ABL78198"/>
        <property type="gene ID" value="Tpen_0796"/>
    </dbReference>
    <dbReference type="GeneID" id="4601257"/>
    <dbReference type="KEGG" id="tpe:Tpen_0796"/>
    <dbReference type="eggNOG" id="arCOG04278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_2"/>
    <dbReference type="OMA" id="CTCTPYL"/>
    <dbReference type="OrthoDB" id="31127at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="393" mass="42738" checksum="5B16538CAD33230D" modified="2007-02-06" version="1">MYLDKFEERMLEGELGEAVALAMRIVVKIAEIFSAERLVKIKHAHVSGVSYENIGDEGLEFLEGLAAKGGRFSVPTTVNPGAVDLELWRKMGVDESYVEKQLRIVGAFRRMGAKVTLTCTPYLYEDISPGDHLAWSESNAVLFANSVIGARTNRDGGPLALMEAIAGRAPLSGLHLDENRRPSLVVDFSESSRYIAENGLFSVAGLIVGRLAGNRVPLVRGLGLQRKDVEELKLFLAAVGATGGTGMVLIDGVSPEAPGDMPGEVEKIGVDDVKAELEKYGGSGWDAVVLGCPHLSYEEVASIIEWFERKGRPRSRVYLYTSREVASRLRSDRLEKLNIHLFADTCMVVSNLGAYASRSVATDSGKAAFYLASKGYSVALLPRRKLLEMLVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD9</accession>
    <name>A1RYD9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752484.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0818"/>
    <dbReference type="EnsemblBacteria" id="ABL78219">
        <property type="protein sequence ID" value="ABL78219"/>
        <property type="gene ID" value="Tpen_0818"/>
    </dbReference>
    <dbReference type="GeneID" id="4601989"/>
    <dbReference type="KEGG" id="tpe:Tpen_0818"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OMA" id="HGCERLR"/>
    <dbReference type="OrthoDB" id="95090at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="17995" checksum="4670D9C07D30EF3E" modified="2007-02-06" version="1">MDVRLRRVEPGDLYYIVELEEKAFGPDAFSLDYLFYLYNRCRDYFFVADYKGLVVGYIVSCREGSQLHVHSVAVVEELRGRGIGRKLLEETIRIARENGLKAVYLEVKTTNTPALRLYEKLGFKRIGVKEKYYNDGSDAYLYALSLEENTPGNLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG3</accession>
    <name>A1RYG3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0842"/>
    <dbReference type="EnsemblBacteria" id="ABL78243">
        <property type="protein sequence ID" value="ABL78243"/>
        <property type="gene ID" value="Tpen_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0842"/>
    <dbReference type="eggNOG" id="arCOG14529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211869_0_0_2"/>
    <dbReference type="OMA" id="SETICGE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="56" mass="7340" checksum="3635EF3503C0DFAA" modified="2007-02-06" version="1">MSLKAWLEEEEEFPEEEEEWEEEEEEEWEDFEEEEEEEFPEEEEEWEEEEEEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK6</accession>
    <name>A1RYK6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Tpen_0885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0885"/>
    <dbReference type="EnsemblBacteria" id="ABL78286">
        <property type="protein sequence ID" value="ABL78286"/>
        <property type="gene ID" value="Tpen_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0885"/>
    <dbReference type="eggNOG" id="arCOG01527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_4_2"/>
    <dbReference type="OMA" id="TYPRVDT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL78286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="631" mass="71982" checksum="0244D0B39A71B77A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL5</accession>
    <name>A1RYL5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol kinase</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752560.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0894"/>
    <dbReference type="EnsemblBacteria" id="ABL78295">
        <property type="protein sequence ID" value="ABL78295"/>
        <property type="gene ID" value="Tpen_0894"/>
    </dbReference>
    <dbReference type="GeneID" id="4600471"/>
    <dbReference type="KEGG" id="tpe:Tpen_0894"/>
    <dbReference type="eggNOG" id="arCOG00025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_2"/>
    <dbReference type="OMA" id="HILLPHD"/>
    <dbReference type="OrthoDB" id="25345at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="263"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="538" mass="59613" checksum="898031991EBBA146" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL7</accession>
    <name>A1RYL7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="8" type="ordered locus">Tpen_0896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752562.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0896"/>
    <dbReference type="EnsemblBacteria" id="ABL78297">
        <property type="protein sequence ID" value="ABL78297"/>
        <property type="gene ID" value="Tpen_0896"/>
    </dbReference>
    <dbReference type="GeneID" id="4600473"/>
    <dbReference type="KEGG" id="tpe:Tpen_0896"/>
    <dbReference type="eggNOG" id="arCOG02694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_3_2_2"/>
    <dbReference type="OMA" id="EWIVILI"/>
    <dbReference type="OrthoDB" id="130531at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12156" checksum="3F3AA5C9F8E994F9" modified="2007-02-06" version="1">MIPVNAPPTVSLQFQIGPTELILLIILALILFGPKKLPELAKAAGEAVRVFREETQKVTSSVEESRTTTSESISDEDLRKLAEKLGVETSGKSRDELVKEIIQKAKEKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM4</accession>
    <name>A1RYM4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752569.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78304">
        <property type="protein sequence ID" value="ABL78304"/>
        <property type="gene ID" value="Tpen_0903"/>
    </dbReference>
    <dbReference type="GeneID" id="4602226"/>
    <dbReference type="KEGG" id="tpe:Tpen_0903"/>
    <dbReference type="HOGENOM" id="CLU_1021651_0_0_2"/>
    <dbReference type="OrthoDB" id="129410at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="296" mass="32644" checksum="CC5A9A6B721F3798" modified="2007-02-06" version="1">MRLKVVESLRSALRSAGCPVVVDDVGARVAEELGLENVLRVDSADLVGLEKVHAAIHESGARRIVGLGGLPAVNAAKVLASPRLRGKSLREVYYDERKPAVEVLLVPLEPAYCTDLSDLVLVYDSKIPAWLVRRAYGNTYVATFAYLEEAGRSPRTRVVVRDMSLAGYSDVDPGESYVSLCSIYEGRAPGPLLIAAMTLSSILGWSLDGAVEAVAGAKFEEALKEAFEQENPESWLEKEMRLRRAQPRLWKRVDLLVEHAWTFYSLRLRSLGFRGKVEVYKLFRSLLSSLPAVGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN8</accession>
    <name>A1RYN8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752583.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0917"/>
    <dbReference type="EnsemblBacteria" id="ABL78318">
        <property type="protein sequence ID" value="ABL78318"/>
        <property type="gene ID" value="Tpen_0917"/>
    </dbReference>
    <dbReference type="GeneID" id="4600813"/>
    <dbReference type="KEGG" id="tpe:Tpen_0917"/>
    <dbReference type="eggNOG" id="arCOG14668">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354381_0_0_2"/>
    <dbReference type="OrthoDB" id="7541at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="792" mass="90714" checksum="DCA93A4F8ADA138A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS0</accession>
    <name>A1RYS0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="7">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="7">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pheS</name>
        <name evidence="9" type="ordered locus">Tpen_0950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752615.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0950"/>
    <dbReference type="EnsemblBacteria" id="ABL78350">
        <property type="protein sequence ID" value="ABL78350"/>
        <property type="gene ID" value="Tpen_0950"/>
    </dbReference>
    <dbReference type="GeneID" id="4601290"/>
    <dbReference type="KEGG" id="tpe:Tpen_0950"/>
    <dbReference type="eggNOG" id="arCOG00410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_2"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="22747at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00282">
        <property type="entry name" value="Phe_tRNA_synth_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022917">
        <property type="entry name" value="Phe_tRNA_ligase_alpha_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="253"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="513" mass="57951" checksum="DB32EB72F22007BF" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS2</accession>
    <name>A1RYS2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752617.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0952"/>
    <dbReference type="EnsemblBacteria" id="ABL78352">
        <property type="protein sequence ID" value="ABL78352"/>
        <property type="gene ID" value="Tpen_0952"/>
    </dbReference>
    <dbReference type="GeneID" id="4601292"/>
    <dbReference type="KEGG" id="tpe:Tpen_0952"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="CEEIRIA"/>
    <dbReference type="OrthoDB" id="107587at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="242" mass="26962" checksum="DA3E7A307BDD36B3" modified="2007-02-06" version="1">MLPGQAWRGVVVDLWGTLLYPSVSLEEYSRERARRIAEALRARGASLGEDEVLEAYKRARRLADRVRNITMIEVSLEGEVVMLLDELGLEPSEELVSEVSEAFIQPYLSLVKPAEGARGFLEGAKKMGYRLVLASNTMSTRHSVELLRRHGLAELFDYMAFSDSVGFRKPHPRFFAHIVAEAGIAPRESFFVGDEEADIRGAKLCGFKTIAYTGFHPYTGNTQPDCTAHSFDAVAECMEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT5</accession>
    <name>A1RYT5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752630.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0965"/>
    <dbReference type="EnsemblBacteria" id="ABL78365">
        <property type="protein sequence ID" value="ABL78365"/>
        <property type="gene ID" value="Tpen_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="4600439"/>
    <dbReference type="KEGG" id="tpe:Tpen_0965"/>
    <dbReference type="HOGENOM" id="CLU_1998850_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="124" mass="13119" checksum="08731C5F6C623E95" modified="2007-02-06" version="1">MSPVVNVAKLDGFLVCLPAPGRMLPGVVKASSVSLDGVRLEAPPGGELLVAPRHLEVRGGRRGLRVEIRGREPFAVGLARVSQGYYVLAPLGGSECWKAFSMGLGEGFGLMEFIYPLGVKNTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV9</accession>
    <name>A1RYV9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0989"/>
    <dbReference type="EnsemblBacteria" id="ABL78389">
        <property type="protein sequence ID" value="ABL78389"/>
        <property type="gene ID" value="Tpen_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0989"/>
    <dbReference type="eggNOG" id="arCOG01426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057644_0_0_2"/>
    <dbReference type="OrthoDB" id="109479at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012431">
        <property type="entry name" value="PDDEXK_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07788">
        <property type="entry name" value="PDDEXK_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="336" mass="39684" checksum="9A8CBFDBCD6C85E4" modified="2007-02-06" version="1">MAALGRGEWERLVKALEEDRELRYALAGLLGFRDLLEKMDATLNEIRALREGQEQLWRNQEKLWEEVKSLREGQGKLWEEVKALREDQRRLWEEVKALRENQEKLWEEVRALREDQGKLWEGQQRLWEEVKALREGQEKLWEEVRKLWEEVKALRENQEKLWEEVKALREGQEKLWEEVKALREEQGKLWKEVKSLREEQGILARKMDSFERRLIALGARWGIESEAAFREAMRGVVEEILGAGEVLRWVYYDEDGEVLGYPSRVEADILIKDKVHVLIEVKPSASSGDIAKLWRLGRLYEKKTGTKPRLVLVTPFIEEEALKAAKQLGIEVYTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW7</accession>
    <name>A1RYW7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0997"/>
    <dbReference type="EnsemblBacteria" id="ABL78397">
        <property type="protein sequence ID" value="ABL78397"/>
        <property type="gene ID" value="Tpen_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0997"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_0_0_2"/>
    <dbReference type="OMA" id="DVEEPNC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="292" mass="30287" checksum="8B2E3EE32DB12078" modified="2007-02-06" version="1">MVKVVAVTGGKGGTGKTVVAASLARLLSDAGARTLLVDLDVENPCSYTLLGAELGSAEEVALFSPVIVEEKCTLCGACASACPAHALVLIPGKRLLFLEPLCESCATCLYACPAGAVARGRKVVGWVKKGRAGGVDLVVGELKPGSRQHHEVMERTLDYASSTWNGYDVAVLDLPPGSGKGIRSALKRADLALLVAEPTRLSLADTRRVHSLAREAGVREVLVLNKYGLPGGVDSEIEAFAASEGLALVKVRYDSALAEAYARGELVVGSKAPSAADLAELAKTVAQLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW9</accession>
    <name>A1RYW9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752664.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0999"/>
    <dbReference type="EnsemblBacteria" id="ABL78399">
        <property type="protein sequence ID" value="ABL78399"/>
        <property type="gene ID" value="Tpen_0999"/>
    </dbReference>
    <dbReference type="GeneID" id="4601555"/>
    <dbReference type="KEGG" id="tpe:Tpen_0999"/>
    <dbReference type="eggNOG" id="arCOG01192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149754_0_0_2"/>
    <dbReference type="OMA" id="YELANEH"/>
    <dbReference type="OrthoDB" id="102366at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="15845" checksum="07DC6EECAD467FDC" modified="2007-02-06" version="1">MINPVSEVRYRYRLAVEHLERAERLFSLGDWAGVVAYSQLAVENFAKAVVAVFEVPTWSYDPSNQLRSLLDAVPLEARREAEELANIARDLAPEHGRTSYGEPSAGLVPSDIYKREHAVEALEKGRRARELAGKVLGAMGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX0</accession>
    <name>A1RYX0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752665.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1000"/>
    <dbReference type="EnsemblBacteria" id="ABL78400">
        <property type="protein sequence ID" value="ABL78400"/>
        <property type="gene ID" value="Tpen_1000"/>
    </dbReference>
    <dbReference type="GeneID" id="4601556"/>
    <dbReference type="KEGG" id="tpe:Tpen_1000"/>
    <dbReference type="eggNOG" id="arCOG00385">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810431_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="342" mass="37373" checksum="28D0A97DC658EFDC" modified="2007-02-06" version="1">MRPPVLAALLALLVVSAYVSAQTPTPMTINVNRDLKVIATYPLEVKYGSWARLVLDVTALKNVTVNKLRVVIVLVYESGEAVLVDRVLLQGKQMPAGYEYQATIEFQVAVPQPPVEPFLELYLVLDYSVNDTARYFEYKAPIAMAPRATYGELSAALAEAQRKAYEADRLAEQVSQLSQRVRSLEIALANESGKCSALGEQLRSVSSEWGALKEKAGALKAENDALKARVSELESENARLRSELASLKEEKGSLASRLTSVQESYQSLLTELGSLRQKYESLSFVASALQAALVALAAVAAVAFLKAPRVARAVKQQSPTAQQLPPQQDRRGEDYREAPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ00</accession>
    <name>A1RZ00_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ala-tRNA(Pro) hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752695.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1030"/>
    <dbReference type="EnsemblBacteria" id="ABL78430">
        <property type="protein sequence ID" value="ABL78430"/>
        <property type="gene ID" value="Tpen_1030"/>
    </dbReference>
    <dbReference type="GeneID" id="4600509"/>
    <dbReference type="KEGG" id="tpe:Tpen_1030"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_2"/>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="OrthoDB" id="60779at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="26599" checksum="D9C9D1E29E5AA1A0" modified="2007-02-06" version="1">MVKLLFQEDSYLKEFDAVVTRVSGNKVFLDQTAFHPGPSGGLDTDKGWLVLPTGDRVEVVQALEEGGDVAHVLARAVNLKPGDRVRGVIDWERRYRMMKLHTASHVLAAVLYKKYGALVTGGHIQPEEAKDDFDLSGVEDWKAAFQQAVEETNRIIGGCLEVKVYWLSRDEALKIPGIVKLAGRLPPEVEKLRIVEIPGVDVQADGGPHVKNTCEIGGIVLKKLESKGAKRKRIYYSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ35</accession>
    <name>A1RZ35_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB domain protein nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1066"/>
    <dbReference type="EnsemblBacteria" id="ABL78465">
        <property type="protein sequence ID" value="ABL78465"/>
        <property type="gene ID" value="Tpen_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1066"/>
    <dbReference type="eggNOG" id="arCOG01875">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134838_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023098">
        <property type="entry name" value="SerK/SbnI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="153" mass="17746" checksum="BCC9A40F69264094" modified="2007-02-06" version="1">MCDHFCRLMQVYVAKIAFMSIGSLKPHEEFSEERVEELLRDMLERGVLIKPIAAESRYGVILDGHHRVEALRRLGVKEVPVALVDYDDERIVVRSWREGFSPSKREVIERALKGSLYPYKTTRHVVVIDGKELHISEVVPNVYYKLKPLLVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ44</accession>
    <name>A1RZ44_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase, chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1075"/>
    <dbReference type="EnsemblBacteria" id="ABL78474">
        <property type="protein sequence ID" value="ABL78474"/>
        <property type="gene ID" value="Tpen_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1075"/>
    <dbReference type="eggNOG" id="arCOG15032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181236_0_0_2"/>
    <dbReference type="OMA" id="RHRTIDP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="99" mass="10056" checksum="6639C16C39C7886A" modified="2007-02-06" version="1">MPESIVLLGVGGLLVIAGATSVAATRNLVKVAMGLQAMILGSLLILSTAVGSSPTPSVDPVLLVVAAAGASEVVSISVLYLAWSRHRTIDPHRISELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ47</accession>
    <name>A1RZ47_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NADH dehydrogenase I chain A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1078"/>
    <dbReference type="EnsemblBacteria" id="ABL78477">
        <property type="protein sequence ID" value="ABL78477"/>
        <property type="gene ID" value="Tpen_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1078"/>
    <dbReference type="eggNOG" id="arCOG01557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147805_0_0_2"/>
    <dbReference type="OMA" id="YGYRYAK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="13273" checksum="B2948B2E8F1DF8A9" modified="2007-02-06" version="1">MSPSSTLALTLFLGIVAGLLVVVLALILVKGPEGKFKRKRYEAGNPPSGEAKTQLPYQYYGYLLLYLTVEPLLAFLYLYPGVPREQALPSFLVLLSAFLFLAPLVAWGVKAADELERWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ73</accession>
    <name>A1RZ73_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752768.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1104"/>
    <dbReference type="EnsemblBacteria" id="ABL78503">
        <property type="protein sequence ID" value="ABL78503"/>
        <property type="gene ID" value="Tpen_1104"/>
    </dbReference>
    <dbReference type="GeneID" id="4601098"/>
    <dbReference type="KEGG" id="tpe:Tpen_1104"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014191_0_0_2"/>
    <dbReference type="OrthoDB" id="104160at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="274" mass="29957" checksum="BB45BAE2FC772829" modified="2007-02-06" version="1">MPTILGELTGFEAESKLYMGLSPLVKIVVPLSFSLDVLLVKDVPSAAALTLAVFLVVLAVKVPLRVVKGFLVLIASLSAFIVLSLTLFTSLPGRVLFEYTLLSVKAEKGVLAWRIVVTDEALSRSFFFVLRILAMILTATLFVATVSDRDVVRALRGLRLPLGVAVAASLFFRGISMFLDDFRVIREAMMARGVDFEKTSLYRRFFLYVNALIPLISLMVSRSYEVSLALESKGLSPLSGPRGGYAFALTRADRLVLGLAALQFALLAAWWVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ81</accession>
    <name>A1RZ81_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Tpen_1112</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752776.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1112"/>
    <dbReference type="EnsemblBacteria" id="ABL78511">
        <property type="protein sequence ID" value="ABL78511"/>
        <property type="gene ID" value="Tpen_1112"/>
    </dbReference>
    <dbReference type="GeneID" id="4601106"/>
    <dbReference type="KEGG" id="tpe:Tpen_1112"/>
    <dbReference type="eggNOG" id="arCOG00422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_1_2"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="OrthoDB" id="30068at2157"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABL78511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="338" mass="38788" checksum="4B7F0B96E1B1D67A" modified="2007-02-06" version="1">MEDSYNELRWNPVLGCWVIVSSSRARRPWRRVEKCPFCPGSEETGYGWDVLVLDNKFPALRRDARVSRSSRDLYVVREAYGAAKVVVETPEHEGDLDSIPFENLVKYLESLGRVTEEECRDERVAYVLPFRNKGEVIGVSLTHPHSQVYVLPFVPPRVSREMAMAREFREKRGGCLFCHVLELEAEEGARTVYENEHFLVFLPFFAMWPYELHVYPKRHVGSLNTLSSDERVSLADALRVTVAAYNSLFGFSLPYIMVFHQSPCRDEGSLHLHVEFYPVHRSADKLKYPAGIEWGGWVFTYDGLPEERAGELREAFRRGVEKLKANGYAARGRVCGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ99</accession>
    <name>A1RZ99_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752794.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1131"/>
    <dbReference type="EnsemblBacteria" id="ABL78529">
        <property type="protein sequence ID" value="ABL78529"/>
        <property type="gene ID" value="Tpen_1131"/>
    </dbReference>
    <dbReference type="GeneID" id="4602026"/>
    <dbReference type="KEGG" id="tpe:Tpen_1131"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_2_2"/>
    <dbReference type="OMA" id="VPAKIYN"/>
    <dbReference type="OrthoDB" id="111480at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="129" mass="14966" checksum="EB37D1E05274578E" modified="2007-02-06" version="1">MREEASLWFRQAERDLEKARNDLVTHDWDSAAFWSQQAAEKALKALLLSRGRVYRGHSLLALAETAKSELGLSVDDIIGDLRELTVHYTISRYPNAANAFPYELYDEAKARELVERARRVVEWVRRHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB8</accession>
    <name>A1RZB8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752813.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1150"/>
    <dbReference type="EnsemblBacteria" id="ABL78548">
        <property type="protein sequence ID" value="ABL78548"/>
        <property type="gene ID" value="Tpen_1150"/>
    </dbReference>
    <dbReference type="GeneID" id="4600956"/>
    <dbReference type="KEGG" id="tpe:Tpen_1150"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_2"/>
    <dbReference type="OMA" id="YVFACHE"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="30781" checksum="9DF0F677E2A2DB3B" modified="2007-02-06" version="1">MRRAPLKKRIVLLLSYLVMSVLAAIYLMPFIRSAVASFMTWSQASAFPPEWVPNPFTLENYAKLFRLSLFPRWVLNTALVSGLVVAANIVTSATAGYAFAFLRFPGKNKIFSALLALLMVPPFITLIPNYILVVKMGLIDNLFGLAFLGSASVSGIFLMRQYYLSLGRELFEAARLDGAGPLRAFVYVALPLSKPALGALAIYQFLGAWNSFLGPLVFLRSPENYTLPVGLNFAFSRSMWTEYTPIIAGSLLASLPTIILYVLLNKYMIRGVVVSAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD7</accession>
    <name>A1RZD7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1169"/>
    <dbReference type="EnsemblBacteria" id="ABL78567">
        <property type="protein sequence ID" value="ABL78567"/>
        <property type="gene ID" value="Tpen_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1169"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="NLGNEDW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="315" mass="34425" checksum="A719A0AA87FEC918" modified="2007-02-06" version="1">MARSVRVLVTGGAGFIGSHLVERLVARGYEVVVLDNLSSGSLENLRSVLGDVEFVRGDVRSREDVEKALRGVDAVFHFAANPEVRVGDPREHFEHNVFATFNVLEAMRRLGVSDIVFASSSTVYGDAEKLPTPEDYGPLKPISVYGASKLACEALISSYTHTFGFKGVALRYANVVGPRATRGVVKDFVRKLRENPRVLEILGDGTQRKSYVWIEDAVEATLLAWERTGEGFEAYNVGSEDAITVREVADIVVSAMGLSNVEYRFTGGVMGGRGWVGDVKNMHLDIGKLKKLGWSPRYTSRDAVRLATLEAIKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF3</accession>
    <name>A1RZF3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1185"/>
    <dbReference type="EnsemblBacteria" id="ABL78583">
        <property type="protein sequence ID" value="ABL78583"/>
        <property type="gene ID" value="Tpen_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1185"/>
    <dbReference type="eggNOG" id="arCOG01997">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_0_0_2"/>
    <dbReference type="OMA" id="MMAIVML"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="213" mass="23407" checksum="AFD872FFD9CEA52E" modified="2007-02-06" version="1">MYHDIFKKARLTRAVGFVVESLKELWDTFLMLFIVVDSIGNIPIFYSLTSGMGREERIKIFEKSVAVASALLVFFAVFGYPFFQYYGVSFTDFKIAGGLLLLIIALQGVFGRVEAEALRSEDLAVVPMATPLLAGPGAIYMVMYLNSVYGLLPTLVSIALNTLASYLILTKSNVLLEKAGKNTILVLSRIFSLLLAVLAVSLIRSGIYEALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL3</accession>
    <name>A1RZL3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752908.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1245"/>
    <dbReference type="EnsemblBacteria" id="ABL78643">
        <property type="protein sequence ID" value="ABL78643"/>
        <property type="gene ID" value="Tpen_1245"/>
    </dbReference>
    <dbReference type="GeneID" id="4600540"/>
    <dbReference type="KEGG" id="tpe:Tpen_1245"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387153_0_0_2"/>
    <dbReference type="OMA" id="AYDPWNN"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="48"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="488"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="716" mass="80014" checksum="D2E5A0838B9C74AD" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL5</accession>
    <name>A1RZL5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1247"/>
    <dbReference type="EnsemblBacteria" id="ABL78645">
        <property type="protein sequence ID" value="ABL78645"/>
        <property type="gene ID" value="Tpen_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1247"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_2"/>
    <dbReference type="OMA" id="CTSSMIV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="125"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="371" mass="40350" checksum="D6ACEE414E987952" modified="2007-02-06" version="1">MVSVNVVYALGSRLIDAYARLRDRLSPGWLEKNKSKLVETKLSLYVFSSSKIGLTGLALVTVTLFLAIFGPFIAWEPYDVYPVLSNPDLAGKLPHPPCLGNCEGLPPAGTDQYGRDVLSLVIRGFRISLVMSVIIVVTSAVLGVVLGLVSGYFGGAVDEAIMRFTDMMLAFPGLILAIAFSLTLRLSLRDFMMSNPAFTGLVASMFALDPRDAPNLANLLSVFLALILVWWPPYARVVRGSVLTVKEQGFIEAARALGLSTRKVLFRHVLPNIMSPLLVMVTFDFATATLSSAALSFLGLGPQPPVPDLGLIISQAGQFFPERSWWIVVEAGTALLLISLGWNLVGDALRDVFDPKTRRSIELKAKIEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL7</accession>
    <name>A1RZL7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1249"/>
    <dbReference type="EnsemblBacteria" id="ABL78647">
        <property type="protein sequence ID" value="ABL78647"/>
        <property type="gene ID" value="Tpen_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1249"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="35744" checksum="16829713A147BE27" modified="2007-02-06" version="1">MSELVVVRDLKKYFKVRGSFSKTVKAVDGVSFEIREGETLGLVGESGCGKSTLGRVVIRLLEPTGGKVFFKGQDVAALKGEKLKQFRRQAQIVFQDPNTSLNPRMTILEILSEPLYEHNIPVDDPEDFITKQLESVGLGREHLYRYPHELSGGQKQRVAILRALLLNPSFVVLDEPTSSLDVSVQAQILNMLKDFQAQRKLSYLFISHDIGVVKYMSQRIAVMYLGKIVELGPSDAVFENPLHPYTKFLLSAVPVPDPKYARARKRLAIPGEPPSPINVPPGCRFHPRCPYATEKCRTGEPPVVEAEPGHFVACWLYSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN5</accession>
    <name>A1RZN5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752930.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1267"/>
    <dbReference type="EnsemblBacteria" id="ABL78665">
        <property type="protein sequence ID" value="ABL78665"/>
        <property type="gene ID" value="Tpen_1267"/>
    </dbReference>
    <dbReference type="GeneID" id="4600482"/>
    <dbReference type="KEGG" id="tpe:Tpen_1267"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="KNIFRAK"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="342" mass="38486" checksum="EE1D8624EC30020B" modified="2007-02-06" version="1">MKLFDPRPKTSRDSLFDRERELEELHRAVDRGLPLVALLGVRRVGKTSVLRTFLGEVNGLYVDARGLVRRADLETRVADALSESLGRLRRFLEGVRGVSVAGFSVEVRWRGRDSVSLAGLLSEIDKRGERFVFALDEVQQSKPPVSAELRSVLAYGYDNLENVTFVVVGSEVGMLRDFLALEDPSSPLYGRYAYEVHVERFSEDLSREFLERGFREEGVEPPPGVVEEAVGFFDGIVGWLVLFGRGYVDGAGSVEELKRAAVNLAAEELGKLSPRERMVLRAVAEGCRSWSEVRRYVDERFGVALPKATLSRIIEKLEKLSIIRGYEFLDPVYREAARRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP7</accession>
    <name>A1RZP7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Queuine tRNA-ribosyltransferases contain PUA domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752942.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1279"/>
    <dbReference type="EnsemblBacteria" id="ABL78677">
        <property type="protein sequence ID" value="ABL78677"/>
        <property type="gene ID" value="Tpen_1279"/>
    </dbReference>
    <dbReference type="GeneID" id="4600746"/>
    <dbReference type="KEGG" id="tpe:Tpen_1279"/>
    <dbReference type="eggNOG" id="arCOG00990">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100996_0_0_2"/>
    <dbReference type="OrthoDB" id="21064at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090304">
        <property type="term" value="P:nucleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040777">
        <property type="entry name" value="DUF5591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17884">
        <property type="entry name" value="DUF5591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF5591" evidence="1">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="252" mass="29403" checksum="A53530F8AC593957" modified="2007-02-06" version="1">MGKRRSRDPRSYDSSKKVLRGRLGEDLRFYNPREVYNALTSNKKVVGWLKFIAESYTPPPEKKVLLFYPCSTVKPYHESRSYKALYKTLESLGEKRRLIHVVAVSEPFGAVPEEYFYEWEEWYDCPGLFEWWCRAHGQPYEREYAEKSIELLASYVAAFLKRTKSSYAHRVAFVRTYTSKLRISPSHTHRRIIELASKASGVEVELLPPKEVVEEIVRTYGAGAWNRQGVAHPAAQEYLRGYLERLLVRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR3</accession>
    <name>A1RZR3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1295"/>
    <dbReference type="EnsemblBacteria" id="ABL78693">
        <property type="protein sequence ID" value="ABL78693"/>
        <property type="gene ID" value="Tpen_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1295"/>
    <dbReference type="eggNOG" id="arCOG05487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111004_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="191" mass="20954" checksum="3B013C9E944F84FB" modified="2007-02-06" version="1">MAKSVGWTALRAALSRRIEEEFPGLEGWEEGLMLGVCEKDFLNYVCVEKGFGGPGEAYAYVEGLAEEKPAEFASILGDWFDLWAAKWRQRVWVAPRGAREEGPSVLEELPAAREARRLALALLIRRGEVCFTDALASAAVRGALARIASRMGVGAARRVAESDPQMLAAEVERAVKEIASRRGPLVLVKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR7</accession>
    <name>A1RZR7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78697">
        <property type="protein sequence ID" value="ABL78697"/>
        <property type="gene ID" value="Tpen_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1299"/>
    <dbReference type="eggNOG" id="arCOG04017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="145" mass="15738" checksum="B80C5C68734E10E3" modified="2007-02-06" version="1">MASIAVRVRLRVARGGVAVETPALANTGYEAETPQLLVPVRLAQELGLWPPGPGVEETEYETAGGPLRVWVAPRACRVSVLAPGASSPEVEADIVVSPLACEVLMSDKLIGELGVAIEDAGRGLWRFRWEPKEALRRSEPPRYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR8</accession>
    <name>A1RZR8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752963.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1300"/>
    <dbReference type="EnsemblBacteria" id="ABL78698">
        <property type="protein sequence ID" value="ABL78698"/>
        <property type="gene ID" value="Tpen_1300"/>
    </dbReference>
    <dbReference type="GeneID" id="4600654"/>
    <dbReference type="KEGG" id="tpe:Tpen_1300"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_1_0_2"/>
    <dbReference type="OMA" id="QLCVKYK"/>
    <dbReference type="OrthoDB" id="120852at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="127" mass="14923" checksum="0FE6686E5D0C1F50" modified="2007-02-06" version="1">MSFEEAEVLRRRAHAFLRNALRLIDEGEYDLAAFSLEQYCRLILEYKLLVLKGSYPRTHSLRRLIRELGEAEPSVLELVENVGNLHYVARLEEAYLASRYFPTAYEEAEVRDLARFVAEVFRRRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT1</accession>
    <name>A1RZT1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinolinate phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1314"/>
    <dbReference type="EnsemblBacteria" id="ABL78711">
        <property type="protein sequence ID" value="ABL78711"/>
        <property type="gene ID" value="Tpen_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1314"/>
    <dbReference type="eggNOG" id="arCOG01482">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140333_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_C" evidence="2">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="11521" checksum="B9B516291BD25E84" modified="2007-02-06" version="1">MSLLGAGVEGAVERLVARVGYRAVGVEVVTLEEALEALEAGARYARFDGVGPATLNGWVRVVKAGFPEARVGASGGVTAENVADYARAGVDVVVTSAPFRALPLDFTTAMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU7</accession>
    <name>A1RZU7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1330"/>
    <dbReference type="EnsemblBacteria" id="ABL78727">
        <property type="protein sequence ID" value="ABL78727"/>
        <property type="gene ID" value="Tpen_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1330"/>
    <dbReference type="eggNOG" id="arCOG14242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817894_0_0_2"/>
    <dbReference type="OMA" id="IPWAVEY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="388" mass="41882" checksum="9E8F378CCBD169BA" modified="2007-02-06" version="1">MQSSLFRVARVLSFFTAHFLGSFEYLLALALLLLAIPYRGSIALFMNSLLDLEGRLGLEGALIPFSMYIYMRALYAKMPQLSPVASRTILGKTLYAVALVTVSAPLTLLTVPLFSLYRQSYLVSVLAAVALAVAQVYGTTPLLVATALVAPVRPVDAIAVLVFEALSRRESLAVVKVGREVMTTAGWLYRVLALVFALLIVYLVSAHGSPSPSCPCEARVTSLLGPAIECKGECPDDVALIVRSLIASLGVEYYLVLLAVASLDSYLDSYLRYLYVLGRRFSAKPLVTLVNLVALSAPLAILLPGFEAAGSLYALLVATLTLWVLKPDIYRSNGLLAYYLVTILALFLLVPALSPLATVAGYYALLALALPMPLIPWAVEYARHKLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S003</accession>
    <name>A1S003_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753048.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1386"/>
    <dbReference type="EnsemblBacteria" id="ABL78783">
        <property type="protein sequence ID" value="ABL78783"/>
        <property type="gene ID" value="Tpen_1386"/>
    </dbReference>
    <dbReference type="GeneID" id="4600669"/>
    <dbReference type="KEGG" id="tpe:Tpen_1386"/>
    <dbReference type="eggNOG" id="arCOG01790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084121_0_0_2"/>
    <dbReference type="OMA" id="TYYKLPG"/>
    <dbReference type="OrthoDB" id="54850at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="31684" checksum="320E80F51BC9C659" modified="2007-02-06" version="1">MVGAESLGESLSRFYEVFPWPEDPLSPEGRARYEAALSFFRGLLEHEWLTGIAGKRRLSVVDVCSGAGLGGVALAKAFTERGLEVELVLVDLRREALELARRFSEAELGSPAETYVLDARELHALGRRFDVALVYGLTTPHFDAFDAARVYSSIAESLADDGVLLVEENDRFYGLIVLGGYREVFYEGDERRGALSVQVGYDSLRGVVRRMHVDLSTGKRAVGETRYWDLAGTLALVWLFFEDVDFARYPGKPRTGIVIAKKPRRKLRPDELGLPTVLRKLQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S031</accession>
    <name>A1S031_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1414"/>
    <dbReference type="EnsemblBacteria" id="ABL78811">
        <property type="protein sequence ID" value="ABL78811"/>
        <property type="gene ID" value="Tpen_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1414"/>
    <dbReference type="eggNOG" id="arCOG03722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115256_4_0_2"/>
    <dbReference type="OMA" id="SMHTCFY"/>
    <dbReference type="OrthoDB" id="102417at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="163" mass="18388" checksum="9A211DB0AF770257" modified="2007-02-06" version="1">MLVAVSLPRVLVERARREAERLGVSLEEYFLEVISGNLDPRDKAEAFIEASKELLEGARKELGKGDVRQAAEKVWVAVALAVKAYAYAKEGKRLASHGDLWRYKEVLVSDLGEWVRDSWAYASSMHTCFYEGWCTEKDVEVGISRAERLVGELEGRVKEKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S042</accession>
    <name>A1S042_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753087.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1425"/>
    <dbReference type="EnsemblBacteria" id="ABL78822">
        <property type="protein sequence ID" value="ABL78822"/>
        <property type="gene ID" value="Tpen_1425"/>
    </dbReference>
    <dbReference type="GeneID" id="4600721"/>
    <dbReference type="KEGG" id="tpe:Tpen_1425"/>
    <dbReference type="eggNOG" id="arCOG01007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_0_2"/>
    <dbReference type="OMA" id="HIVWLIR"/>
    <dbReference type="OrthoDB" id="36067at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="345" mass="35620" checksum="75C3A67FB55A697E" modified="2007-02-06" version="1">MEIVESLLGRRSLAVLLLLALVAAALPLSILSGTVYKPWDVLRLLQEGSSDAGIVLALRARRAFVALLVGALLGGAGALTQASFRNPMASPFTLGISQASALGVAVALVTGIGGTGGAWVLTFSRPTLIALFAFAFAVVQVFVVLALSWKAGLDPRALVLSSIAISFVYQAALYLMQYLVLNEVQLATVIFWTFGDLGRAGWSELGVLAAGASALLPVYVAFHKDLDLLSFGDELAASSGVSPRATRLVVTLVAALGAALATAFVGILAFLCLVSPHLARLFVGGRHRYLVPASMLTGSLLLLVSDAASRSVLSPVVLPVGIVLSLIGAPVLVALLLRGSGRAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1S044</accession>
    <name>A1S044_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plasma-membrane proton-efflux P-type ATPase</fullName>
            <ecNumber evidence="10">3.6.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_1427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.6" evidence="10"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753089.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1427"/>
    <dbReference type="EnsemblBacteria" id="ABL78824">
        <property type="protein sequence ID" value="ABL78824"/>
        <property type="gene ID" value="Tpen_1427"/>
    </dbReference>
    <dbReference type="GeneID" id="4600723"/>
    <dbReference type="KEGG" id="tpe:Tpen_1427"/>
    <dbReference type="eggNOG" id="arCOG01578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_4_2"/>
    <dbReference type="OMA" id="FTIFGWF"/>
    <dbReference type="OrthoDB" id="17967at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="802" mass="87343" checksum="B9A8818BAA2EA617" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S079</accession>
    <name>A1S079_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753124.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1462"/>
    <dbReference type="EnsemblBacteria" id="ABL78859">
        <property type="protein sequence ID" value="ABL78859"/>
        <property type="gene ID" value="Tpen_1462"/>
    </dbReference>
    <dbReference type="GeneID" id="4600588"/>
    <dbReference type="KEGG" id="tpe:Tpen_1462"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="IQYLNFI"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="252" mass="27668" checksum="E35E1B1841032558" modified="2007-02-06" version="1">MSQQVYAVEAVDLYKSYGDTWALNGLTMRIGPGEIYGLLGPNGAGKTTTLKILAGLLKPSRGYARIYGVEVSSRRVEALRLVGYVPENPVVFQNLTVEEFLRFVAALRGLDWREVSGDAEYYLEVFGLAGRKDSFMGELSRGMVQKVLVSAAFLVRPKVLLMDEPTAGMDPESQHVFKEEVRRLSSKGVTSLISSHQLDSVERLCTRVGIIYKGRLIAEGTVEELKSRVSEKPGSTLEEAFLKIVKSGESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F1</accession>
    <name>A1S0F1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753196.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1535"/>
    <dbReference type="EnsemblBacteria" id="ABL78931">
        <property type="protein sequence ID" value="ABL78931"/>
        <property type="gene ID" value="Tpen_1535"/>
    </dbReference>
    <dbReference type="GeneID" id="4600377"/>
    <dbReference type="KEGG" id="tpe:Tpen_1535"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_1_2"/>
    <dbReference type="OMA" id="IRAYKMS"/>
    <dbReference type="OrthoDB" id="71426at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="263" mass="29314" checksum="4E0C7C46AC14C948" modified="2007-02-06" version="1">MSSRIVRYIEGSSIVHRLDPRVKLFFVGSVVLAASLSYNLLLAVLTLALGLSFYLLARLPFSKTKNTWKFILIVALVLSFLNYLFVAVLYHRPRGELLEAFMSAELLSRSITPVLKLLAVATVTVAFVYTTPPHLYAPALGQLGLSYRAAYAVHLGFRYFPQFVDELRRTLEAQMARGYRPRGGKNPLGRILAVIPLIVPVTVSATLSIYDVSDAMELRGFGGTKCHTWYRKLSMKTLDKAFAILSAVISLVFLALYVLRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I5</accession>
    <name>A1S0I5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
            <ecNumber evidence="6">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_1570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753230.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1570"/>
    <dbReference type="EnsemblBacteria" id="ABL78965">
        <property type="protein sequence ID" value="ABL78965"/>
        <property type="gene ID" value="Tpen_1570"/>
    </dbReference>
    <dbReference type="GeneID" id="4601528"/>
    <dbReference type="KEGG" id="tpe:Tpen_1570"/>
    <dbReference type="eggNOG" id="arCOG00312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_2"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6 7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-215); in linked form" evidence="6">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="6">
        <location>
            <begin position="209"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-49); in linked form" evidence="6">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="221" mass="25163" checksum="676624007F48B896" modified="2007-02-06" version="1">MSEIRMPLLGEKAPSFTAKTTHGVINFPDDFRGKWVVLFSHPADFTPVCTTEFVSFQKKMEEFKKLNVQLIGLSIDQVFSHIKWVEWIKEKLGVEIEFPIIADDTGEIAKKYGMIHPGKGTNTVRAVFVIDPNGVLRAVLYYPQEVGRNMDEILRLVKALQVSDKHGVALPANWPNNELIGGKVIIPPASDEKTAKERLEKAARKEIECFDWWFCYKSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J0</accession>
    <name>A1S0J0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753235.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1575"/>
    <dbReference type="EnsemblBacteria" id="ABL78970">
        <property type="protein sequence ID" value="ABL78970"/>
        <property type="gene ID" value="Tpen_1575"/>
    </dbReference>
    <dbReference type="GeneID" id="4600561"/>
    <dbReference type="KEGG" id="tpe:Tpen_1575"/>
    <dbReference type="eggNOG" id="arCOG01757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="HVAGWSP"/>
    <dbReference type="OrthoDB" id="40164at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="3">
        <location>
            <begin position="119"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="35628" checksum="C12E93826F5F7C6C" modified="2007-02-06" version="1">MYTVYVALDLKEWERRIVEETLSREARIVYKSGKGFAGIEEADVAIAFILPRDAAQAAGRLKFVQVPAAGADNLDLEYLFERGVKVATSKGCNARAVAEHAFALILALAKRVVEQDGEVKRGLWRSFTEENFLADLDGSTVTIVGYGNIGREVARIAKAFNMRVLAVKKNPEKDSLADEVYPVERLAEALSQADFVVLALPLTRETYRLIGEKELKSMKKTAYLVNVGRGAVVDEEALYRALSEGWIAGAGIDVWWRYPPDKDYPSPLGVHKLPNVVATPHKAGWTRKARENCLRFACENVLRFVRGEEPLNLLEPSKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L5</accession>
    <name>A1S0L5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator, PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1600"/>
    <dbReference type="EnsemblBacteria" id="ABL78995">
        <property type="protein sequence ID" value="ABL78995"/>
        <property type="gene ID" value="Tpen_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1600"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975288_0_0_2"/>
    <dbReference type="OMA" id="DHAAKIS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="33900" checksum="7FAE8B811E20CE6C" modified="2007-02-06" version="1">MLNLVVTFKRVIRISGGYYVALPKGWVEQLGLAGSYVKIEYLPDGSLLVRPAERGREEQLSVKVLCDEHVFRRILSAYLKGYEVIEVELSPGCLDKARAGVESAQRLLPGLELVEEGSERLVLQCFIKPDYNLDSIIYRMDSTTREMLLKATDLLLGGGDASAVSALDDRVDRLYFLAVRIMRRRIRDPTLSPDERLRLLDMRLTAKNLENLGDSYESLARLDARLPEEGLAEASRALADLQRRSVKLFLEGSESRDELLLDYRRLEEYLKSREGVWPRAVVEKLAFALVLVKDIIDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N7</accession>
    <name>A1S0N7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase, FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753282.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1622"/>
    <dbReference type="EnsemblBacteria" id="ABL79017">
        <property type="protein sequence ID" value="ABL79017"/>
        <property type="gene ID" value="Tpen_1622"/>
    </dbReference>
    <dbReference type="GeneID" id="4601025"/>
    <dbReference type="KEGG" id="tpe:Tpen_1622"/>
    <dbReference type="eggNOG" id="arCOG00025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_2"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="OrthoDB" id="25345at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="259"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="499" mass="55061" checksum="A68A3F83D64E9D03" modified="2007-02-06" version="1">MKILAVDVGTSTLKSALVDLEKGVTGFVRKEIPILRPEPEAAEHDPETLFRMVLENLKETLAKAGVSEVDCLVLSGYLFGVLALDSKGEPLTNVLTWLDRRATRTLRTLFQVLNPVDVYRRTGCPPLFIYPLAKIFWLKTARENTYRATKRFLDAKGYLLLRLTGEEVMEVSSASGSQLLNLERKDWDHEIIHSAGLDLDKLPQLVEPDTIVGDVPVSIARSIGLKSPVPVVAGVFDGAAVSLGLGGLEEDVATSHLSTSTMLRVASRIPVIDSSPKMRFQTYYSLRGYWLPGGAVNSGAVVLRWFRDNFAQLERLVAQELGVSEYELLDNEAALSPPGSNGVVFLPYISGERFPEFGNNASGVIYGLREWHTRKDVLRAIMEGVAFNLNLVNEALRENGLSFREVRITGGGANSRLWLQILADVLGVPIKAFTKGDAALLGSSFVAKIAIEGNAAGVEHLVKFDKTVEPIPENQRIYMERFKEFKYLLNALLPMFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N9</accession>
    <name>A1S0N9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyglucarate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.20" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753284.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1624"/>
    <dbReference type="EnsemblBacteria" id="ABL79019">
        <property type="protein sequence ID" value="ABL79019"/>
        <property type="gene ID" value="Tpen_1624"/>
    </dbReference>
    <dbReference type="GeneID" id="4601027"/>
    <dbReference type="KEGG" id="tpe:Tpen_1624"/>
    <dbReference type="eggNOG" id="arCOG04974">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_4_1_2"/>
    <dbReference type="OMA" id="WNRVDDY"/>
    <dbReference type="OrthoDB" id="54390at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008672">
        <property type="term" value="F:2-dehydro-3-deoxyglucarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="253" mass="27845" checksum="91E7C5DC2EF76C4F" modified="2007-02-06" version="1">MIGKLPRLLSEKRAALGAWVTIGNPEVPEMLSLLGFDWLLFDMEHAPLDFQLLEYMLIAVKNDATPLVRVPFNDPVYVKRVLDLGVAGILFPLVNKSEDAKLAVASTKYPPRGIRGVGPRRAASYGLRTNEYFEEAGKVLVVVQIETQEAVKNIEEILSTDGVDAFFIGPNDLSFSFGYRSWKEEAVRRAIERVADASRSLGVPGGMYCSDDESLEFALSLGFSLIALGSDYRFLVAGAKSRLEKAKKLLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P7</accession>
    <name>A1S0P7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-vinyl reductase, 4VR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753292.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1632"/>
    <dbReference type="EnsemblBacteria" id="ABL79027">
        <property type="protein sequence ID" value="ABL79027"/>
        <property type="gene ID" value="Tpen_1632"/>
    </dbReference>
    <dbReference type="GeneID" id="4600911"/>
    <dbReference type="KEGG" id="tpe:Tpen_1632"/>
    <dbReference type="eggNOG" id="arCOG01688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982185_0_0_2"/>
    <dbReference type="OMA" id="ARIIHIE"/>
    <dbReference type="OrthoDB" id="114615at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="32149" checksum="5C0762A48565B3E1" modified="2007-02-06" version="1">MGHDRTIGGSFRPYHMGRVAIFPEGKPYFFHVVLNPEAYVVVGVLRDILDVFAGEKVPILLFKTSTPPRGSGEDIRVIIAADIKEDREAEKIVAALRRKRFVKEAEYAPPVAPGIGLDAWSYPPVAAGERAIVFREQVFRRLVRFGWEHLGSGYGGILYRTFFEAGREVYENFYKRLGLGKEDLVRLAEEMFRLMGFGILRIVELTNDRMVAQVYDNVECKSLVGIEGAEGTIIRGLLAGWLSGYWGVDIKTVRPKETKCIARGDPYCEYVFRRGSYDEEVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T3</accession>
    <name>A1S0T3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753328.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1668"/>
    <dbReference type="EnsemblBacteria" id="ABL79063">
        <property type="protein sequence ID" value="ABL79063"/>
        <property type="gene ID" value="Tpen_1668"/>
    </dbReference>
    <dbReference type="GeneID" id="4601250"/>
    <dbReference type="KEGG" id="tpe:Tpen_1668"/>
    <dbReference type="eggNOG" id="arCOG05752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084705_1_0_2"/>
    <dbReference type="OMA" id="TIYAPFT"/>
    <dbReference type="OrthoDB" id="91944at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="168" mass="16963" checksum="911AA9FCCA017B80" modified="2007-02-06" version="1">MAKASKSKLVATVGVFAALTTVATVIVQIPVPETKGYINLGDAVVLLSGIVLGPAAGALAGGIGSALADVLSGYAHWAPFTLVIKGVEGFLAGLLSRTGKTALRTLGVLLAAFEMILGYFLVETLLYGVGAALAELPGNVFQAVFGALVALLAGEQLRRRIGVADAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T6</accession>
    <name>A1S0T6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1671"/>
    <dbReference type="EnsemblBacteria" id="ABL79066">
        <property type="protein sequence ID" value="ABL79066"/>
        <property type="gene ID" value="Tpen_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1671"/>
    <dbReference type="eggNOG" id="arCOG07455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048987_0_0_2"/>
    <dbReference type="OMA" id="EEAYIEP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="372" mass="41261" checksum="BD7C13AB6D27A9EA" modified="2007-02-06" version="1">MLINFLQNARAMSSLLLAFLLILLLTLPSLYAVPNNSARLVAWVVPWGERVDAREVPGYMVPGVVVAYDVDRGVEPPSLSQWLSYSVSQIEALRSSGREVFVNLFCEKYVPSWSWRGGLKTVRLDGRVLAELKRVLGDGEGAYIGFSELTSCVNDAGCREELSAAYRELREAFPAAKLYYYGSGGDDVNALLDLQAKAGLDYVGIDFWDLELGPQGVRVKRYLVSKVEELARRLGWGKVIVGEVGLRVDDEEAYIEPWNWGRRRVFNESADARYYSEILTGLLVEEKVAPAFIGVWAWNDGVFAVRGENDVLDVLSRFATSSPEGSASTVRLNTPLPWVFPWVAVALAPIAVFVAVILQRRHRSKRGAPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X5</accession>
    <name>A1S0X5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1710"/>
    <dbReference type="EnsemblBacteria" id="ABL79105">
        <property type="protein sequence ID" value="ABL79105"/>
        <property type="gene ID" value="Tpen_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1710"/>
    <dbReference type="eggNOG" id="arCOG02218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_1_2_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="72" mass="8079" checksum="2337F59857304247" modified="2007-02-06" version="1">MNTTSAKVPNRVKKILEKRGAKVSKPTGKAPTAEKTGEEELRKALDEFASTLKDKIDPRAWAEIIDENRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z2</accession>
    <name>A1S0Z2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753387.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1727"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79122">
        <property type="protein sequence ID" value="ABL79122"/>
        <property type="gene ID" value="Tpen_1727"/>
    </dbReference>
    <dbReference type="GeneID" id="4601752"/>
    <dbReference type="KEGG" id="tpe:Tpen_1727"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_2"/>
    <dbReference type="OMA" id="GRFTNMS"/>
    <dbReference type="OrthoDB" id="96698at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="329" mass="36716" checksum="92E2BC41CA77DF0E" modified="2007-02-06" version="1">MKARATSTPANPWASEVTIVIPTLKEERGVGLVIDELKGEGWTNILVVDGGSTDRTREVAAEKGARVVLQEGRGKADAVRTALRYVETPYIVVMDGDYTYPARHVAELLRTARERGLDEVIGARTRGRENIPLLNRFGNWVITETFNVLFGTNLSDVCSGMYLVRTEVAREVQFESKGFSVEVEIAAHVASTTRRIGEIPIEYRPRVGEPKLRKRHGLRIVLDAFRLALRYNPVFLFFSAASIVLIPSLVLAAWVGYRWLVQGVKHQVWGIIAIVGTGVGLVALLNAIMSLYLKRLELRITERLTRLEAELKATTKQPSKKDADSRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S147</accession>
    <name>A1S147_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753442.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1782"/>
    <dbReference type="EnsemblBacteria" id="ABL79177">
        <property type="protein sequence ID" value="ABL79177"/>
        <property type="gene ID" value="Tpen_1782"/>
    </dbReference>
    <dbReference type="GeneID" id="4601926"/>
    <dbReference type="KEGG" id="tpe:Tpen_1782"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_2_2"/>
    <dbReference type="OMA" id="CYARLYT"/>
    <dbReference type="OrthoDB" id="37613at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="281" mass="31428" checksum="2823C45789772BCB" modified="2007-02-06" version="1">MEGVVYRRIRVESVLSKSGLYDLDYAYNPYVGCSHGCAYCYARAYTRHTEVARNWGRVVYVKENAVEVLRREVRVARKGVVGVSTLTDPYQPVEEVEELTRRGLEVLLGEGFRVSVQTKSPLVVRDLDVLEKYAGLVDVGFTVTTLDPETARLVEPGAPPPASRVGALRKVSEAGVETWVFVGPIMRGVNDSAENLRKIVETAGRVGAKVFYDFFHFKPALDESMSPVLEKHPDATSTDPRWRALVERVLLEACRDEGVECRPAFPKKSTSRQSRLTSFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S150</accession>
    <name>A1S150_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1785"/>
    <dbReference type="EnsemblBacteria" id="ABL79180">
        <property type="protein sequence ID" value="ABL79180"/>
        <property type="gene ID" value="Tpen_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1785"/>
    <dbReference type="eggNOG" id="arCOG04215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061573_1_0_2"/>
    <dbReference type="OMA" id="FQRDWCL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="PTHR41700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="275" mass="30955" checksum="EB1764C15581F826" modified="2007-02-06" version="1">MEEVEVRPLEKAEEFSQAMEVQKTAWGMPDIEVIPSRILIAIARNGGLVLGAFARGRLVGYSFGFLARDSQGLYLYSHHTGVIPEYEDKGVGFALKAKQREYALRMGLSRVKWTFDPLQSRNSYFNLVKLGAVVREYHVNYYGELTDQLNRGLPSDRVVAEWYLESPRVVNRLGGRRPAAPGGAVPVIRVRGSEPVFEPAESTSVLVLVPLDIGGVKSRDPELALKWRLETRKAFQYYFSKGYIDHHYVRLDENYGAHVLSKVSLEEVLLDALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S151</accession>
    <name>A1S151_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1786"/>
    <dbReference type="EnsemblBacteria" id="ABL79181">
        <property type="protein sequence ID" value="ABL79181"/>
        <property type="gene ID" value="Tpen_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1786"/>
    <dbReference type="eggNOG" id="arCOG00701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_2"/>
    <dbReference type="OMA" id="AWAREAC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="221" mass="23973" checksum="C43E90A76B0E1317" modified="2007-02-06" version="1">MPAFEEAVRAGADFVETDVHRTRDGALVCIHDATLNRTTNGDGYVSEKTVDYVRSLDAGSWFSGRYAGVQVPLFEEFLDYIASTSAGVFVEVKVPGIEEEVVGRILQWGLEERAVVLSGYWSVLRRVKELDPGIATLADLPSPSPQSISSAVKVANIVSIHAALFEEEHALQAHRRGLLVNVWGVNGCEDALRVVELGADFVTVDNPGAIVECLRARGLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S168</accession>
    <name>A1S168_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753463.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1803"/>
    <dbReference type="EnsemblBacteria" id="ABL79198">
        <property type="protein sequence ID" value="ABL79198"/>
        <property type="gene ID" value="Tpen_1803"/>
    </dbReference>
    <dbReference type="GeneID" id="4601796"/>
    <dbReference type="KEGG" id="tpe:Tpen_1803"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="OMA" id="CPGPLMD"/>
    <dbReference type="OrthoDB" id="124510at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="78" mass="8419" checksum="55372610B49B9959" modified="2007-02-06" version="1">MPEITVDARGMACPGPISALTRAYRNAQNGDLIIVLATDPGFEPDVKAWVERTKNELVELAKVDGNVIKAVIKVTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S169</accession>
    <name>A1S169_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753464.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1804"/>
    <dbReference type="EnsemblBacteria" id="ABL79199">
        <property type="protein sequence ID" value="ABL79199"/>
        <property type="gene ID" value="Tpen_1804"/>
    </dbReference>
    <dbReference type="GeneID" id="4601797"/>
    <dbReference type="KEGG" id="tpe:Tpen_1804"/>
    <dbReference type="eggNOG" id="arCOG02064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094970_2_0_2"/>
    <dbReference type="OMA" id="WAMFKLL"/>
    <dbReference type="OrthoDB" id="100378at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14986" checksum="60A66FDADBDA52D4" modified="2007-02-06" version="1">MSKGLAIIMFSGTADKFIPLGVLTQTAANLGVPVRIFVTGFATPYFTKNKPQPRFPKEFEDMVPGLLKGLEKMKAPSWYDMVREAKEVGDVKVYVCSLIAEALGLKKEDLDPIVDDIVGATFFMKETAEYEVIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S170</accession>
    <name>A1S170_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753465.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1805"/>
    <dbReference type="EnsemblBacteria" id="ABL79200">
        <property type="protein sequence ID" value="ABL79200"/>
        <property type="gene ID" value="Tpen_1805"/>
    </dbReference>
    <dbReference type="GeneID" id="4601798"/>
    <dbReference type="KEGG" id="tpe:Tpen_1805"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="OMA" id="HSRRWPG"/>
    <dbReference type="OrthoDB" id="35243at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="249" mass="27610" checksum="6CA4482F94B2AFB7" modified="2007-02-06" version="1">MTVLKLEELSYVELKEEVEKRKIDSFVLPVGTVEPHGTHLPLGTDTLIPSALGEYVAEKVNAVLLPPVHYGVTTGLHGYFGSVRVQPETLEALVYEILESMSLHGFRYGLILNGHGGNTQALDNAAKKAWLRNKLAVMVVDWWILAREKGVTREVLGKEGGHAATDETAMVLAIRPELVKRNLYTPSAVYVYSAAVKAYPYPGTVINYSEGEGDVEFKPGEARRYFERVADLVAEVFLRYKKSLEGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S197</accession>
    <name>A1S197_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1832"/>
    <dbReference type="EnsemblBacteria" id="ABL79227">
        <property type="protein sequence ID" value="ABL79227"/>
        <property type="gene ID" value="Tpen_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1832"/>
    <dbReference type="eggNOG" id="arCOG00272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992557_0_0_2"/>
    <dbReference type="OMA" id="IGYTYIF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="165"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="298" mass="31556" checksum="8D2164086649F7BD" modified="2007-02-06" version="1">MHAKKGFYLDNNYRSSVLGEVFALVAALSFSGAAIFYRAGVRGSQVNPIVLSGLRGMFALALLLVVGFFYRVDFSKPPVFYLAVFLSMLGSFILGDSSFLYGLQRAPLGVVYPVAYTFSVFTALFSHFILGEELTLRDAVSSLLIVLGVALVYSENFSLGKQALVGALAGLSASVSWGAGATLMGLALRWGNAVEVNISRLSMLVIATLPLILKNSSEVFRQVRVHLLALGGILGIGVGPLLFMNSISFIGASRSSIFISSTPVLTVLLSRIFLGEKTGGKLLLGTLAVSAGLALQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A3</accession>
    <name>A1S1A3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753498.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1838"/>
    <dbReference type="EnsemblBacteria" id="ABL79233">
        <property type="protein sequence ID" value="ABL79233"/>
        <property type="gene ID" value="Tpen_1838"/>
    </dbReference>
    <dbReference type="GeneID" id="4602076"/>
    <dbReference type="KEGG" id="tpe:Tpen_1838"/>
    <dbReference type="eggNOG" id="arCOG07626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801797_0_0_2"/>
    <dbReference type="OrthoDB" id="131972at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="166" mass="18491" checksum="6514AF05F37DCD3C" modified="2007-02-06" version="1">MTIREEARVRGLRPVHVFVASMLAEFRENGVLNFGILRAATEKTGAKIAEMLDEDTPRNLEGAVKFLAEALEVSKDFDVEKNGSILRLRVKSKLCRFCPKGVGGLELPGPLCPFPGLFKGFLEHSAGLKLAYPENFMYRDRDGYCNFLLEVIGTGSDASMKMFQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C8</accession>
    <name>A1S1C8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751383.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1863"/>
    <dbReference type="EnsemblBacteria" id="ABL79258">
        <property type="protein sequence ID" value="ABL79258"/>
        <property type="gene ID" value="Tpen_1863"/>
    </dbReference>
    <dbReference type="GeneID" id="4600328"/>
    <dbReference type="KEGG" id="tpe:Tpen_1863"/>
    <dbReference type="HOGENOM" id="CLU_2447828_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="89" mass="10372" checksum="D38E6418E82382AF" modified="2007-02-06" version="1">MSIRENVVIKVRRLKDFVEHTSRADRVFYYSRGTYYVAIAGSMIWAGDIGVEPEDVRKEFLKVLNVKGVEVEDILKPYEVPDYLKSLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C9</accession>
    <name>A1S1C9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1864"/>
    <dbReference type="EnsemblBacteria" id="ABL79259">
        <property type="protein sequence ID" value="ABL79259"/>
        <property type="gene ID" value="Tpen_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1864"/>
    <dbReference type="HOGENOM" id="CLU_2327398_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="98" mass="11488" checksum="2F9D4D5A6814DD4E" modified="2007-02-06" version="1">MRAKDFLVEEVREWLAEYLARHQGGIATVLARYAARDLRRYHPVAVSLAITQVKMVTDKLGRVWVLDDKLTRYAKVRKYVYRRENGGVGEVVREYYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F3</accession>
    <name>A1S1F3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751408.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1888"/>
    <dbReference type="EnsemblBacteria" id="ABL79283">
        <property type="protein sequence ID" value="ABL79283"/>
        <property type="gene ID" value="Tpen_1888"/>
    </dbReference>
    <dbReference type="GeneID" id="4600316"/>
    <dbReference type="KEGG" id="tpe:Tpen_1888"/>
    <dbReference type="HOGENOM" id="CLU_1154404_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="27207" checksum="4B7C17DA5A87A79D" modified="2007-02-06" version="1">MSADRRPVTRVKWETDADVAAGRDVVAWLNDLSPKVLPMGEYVVLIHDVSDLHSLAILSRLNRRCTFILEFPVDVDPAFAFTVFELLRFNPRIRFRDPSFSYLRGELARLRPGEDTVVTGHLVWRGDFRAILARRNSFYVAPQLGYVASGYFTPDNDPYLYYVSRVQGLKPEVVEVPLQPVEVKPPPPPVPVKPRLPREKPQNFVANPEGGGEEGEPEFEEVDLEELGEEEEGGEKEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW42</accession>
    <name>A1RW42_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0012"/>
    <dbReference type="EnsemblBacteria" id="ABL77422">
        <property type="protein sequence ID" value="ABL77422"/>
        <property type="gene ID" value="Tpen_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0012"/>
    <dbReference type="eggNOG" id="arCOG05379">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132454_0_0_2"/>
    <dbReference type="OMA" id="WAVFAQL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="160" mass="17824" checksum="0480C0B35E0C1ADF" modified="2007-02-06" version="1">MSQQSSKKIVLPRDVSPDHVLGLLEVLHTMGGLTDSMYVGDAVHENIQVLPKAIDVAEALGLIKTHKGNLQLTELGKRVARSDPKSIKKLLRNAISNIEPLAEIASTLKEKKRMTVEEFDAIIGKYYPGNVEEARKNVLIWGAFLHLFVMDEEDEEILPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB2</accession>
    <name>A1RWB2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751757.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0082"/>
    <dbReference type="EnsemblBacteria" id="ABL77492">
        <property type="protein sequence ID" value="ABL77492"/>
        <property type="gene ID" value="Tpen_0082"/>
    </dbReference>
    <dbReference type="GeneID" id="4601972"/>
    <dbReference type="KEGG" id="tpe:Tpen_0082"/>
    <dbReference type="eggNOG" id="arCOG14884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682795_0_0_2"/>
    <dbReference type="OrthoDB" id="110624at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="160" mass="18612" checksum="551E04DCF37C175B" modified="2007-02-06" version="1">MEELVKSVKETLNMIDAGIRDKKFPEQMRIYIEQLGRNLRHFIEVIEVTGRENTIQSPISPSSRSAMFNLRKAFYATLSREIKQNKVDKERSLEEWRKVASRIIETFEKRGLTEAPSKIILTYEIKEEDGKRYIAFRDARILYFGLEGILSVSLVEQPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB9</accession>
    <name>A1RWB9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0089"/>
    <dbReference type="EnsemblBacteria" id="ABL77499">
        <property type="protein sequence ID" value="ABL77499"/>
        <property type="gene ID" value="Tpen_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0089"/>
    <dbReference type="eggNOG" id="arCOG07442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200516_0_0_2"/>
    <dbReference type="OMA" id="TAYCVKC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="54" mass="6206" checksum="D624F383A3398AE8" modified="2007-02-06" version="1">MSHQKITAYCVKCRKQVEMKNPQQVTLKNGRLAYKGTCPNCGTTVYRFIGRVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC0</accession>
    <name>A1RWC0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0090"/>
    <dbReference type="EnsemblBacteria" id="ABL77500">
        <property type="protein sequence ID" value="ABL77500"/>
        <property type="gene ID" value="Tpen_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0090"/>
    <dbReference type="eggNOG" id="arCOG00017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133047_1_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="116" mass="13130" checksum="704643CED84A4244" modified="2007-02-06" version="1">MSYSTTSEMAHLKAPCEEISRRVLPAVRSILVRYLYEQEGLTQLQIAKLLGISQSSVSRYLNSQRGLSQRDILEIPSIDEKLRETVHGIVEGKLRGEEALCSICQYIRMMSREVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC9</accession>
    <name>A1RWC9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751774.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0099"/>
    <dbReference type="EnsemblBacteria" id="ABL77509">
        <property type="protein sequence ID" value="ABL77509"/>
        <property type="gene ID" value="Tpen_0099"/>
    </dbReference>
    <dbReference type="GeneID" id="4602015"/>
    <dbReference type="KEGG" id="tpe:Tpen_0099"/>
    <dbReference type="HOGENOM" id="CLU_1902049_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14028" checksum="108DC70F15A78E4F" modified="2007-02-06" version="1">MASLELEDLLDLALGLAEKAIYVLLASYIVAFTAALLGVGEALKLPPVAAAVYFTGALLLKVIRGVLPSLQGRGAYLFALAPSTVGLAALINALFNYAETRVELYAYAVMAVIFALKVYSEKRGYVVIMAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE6</accession>
    <name>A1RWE6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0116"/>
    <dbReference type="EnsemblBacteria" id="ABL77526">
        <property type="protein sequence ID" value="ABL77526"/>
        <property type="gene ID" value="Tpen_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0116"/>
    <dbReference type="eggNOG" id="arCOG04347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451481_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="207" mass="23239" checksum="94F95DE5664281F9" modified="2007-02-06" version="1">METLDKLFESGVYSPTNFAMSLGLDRKLRGIVYNLARGRVLDVGCGDGYYSLPLLENAQEVVCVDPLARKGSESDPRLHVVKAIAEYLPLRSKSVEFSTAMFSFRDFLDKPRGLSEMKRASRIGVFIVEIFNPSTWFRPFLYAYVLFIAPLLAFLVSRGKGKGWRLLYPTIRIMPRASLFERMGGKVLVSKGFGSLAIVYLPVNPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG0</accession>
    <name>A1RWG0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="7">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ileS</name>
        <name evidence="10" type="ordered locus">Tpen_0130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751805.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0130"/>
    <dbReference type="EnsemblBacteria" id="ABL77540">
        <property type="protein sequence ID" value="ABL77540"/>
        <property type="gene ID" value="Tpen_0130"/>
    </dbReference>
    <dbReference type="GeneID" id="4600715"/>
    <dbReference type="KEGG" id="tpe:Tpen_0130"/>
    <dbReference type="eggNOG" id="arCOG00807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_2"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="691"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="602"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL77540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1062" mass="123690" checksum="6B33A0E6E6590DC5" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG2</accession>
    <name>A1RWG2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751807.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0132"/>
    <dbReference type="EnsemblBacteria" id="ABL77542">
        <property type="protein sequence ID" value="ABL77542"/>
        <property type="gene ID" value="Tpen_0132"/>
    </dbReference>
    <dbReference type="GeneID" id="4600717"/>
    <dbReference type="KEGG" id="tpe:Tpen_0132"/>
    <dbReference type="eggNOG" id="arCOG02081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473009_0_0_2"/>
    <dbReference type="OrthoDB" id="67833at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="456"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="577" mass="62115" checksum="8B89C21081279AF5" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH6</accession>
    <name>A1RWH6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751821.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0146"/>
    <dbReference type="EnsemblBacteria" id="ABL77556">
        <property type="protein sequence ID" value="ABL77556"/>
        <property type="gene ID" value="Tpen_0146"/>
    </dbReference>
    <dbReference type="GeneID" id="4600638"/>
    <dbReference type="KEGG" id="tpe:Tpen_0146"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="36309" checksum="D48C65479FCB2D93" modified="2007-02-06" version="1">MSSVLTVRNLRLYFSTRKGVVKAVDNVSFDLKKGETLAIVGESGCGKSSLARALIRLLPRNVHTFTGEIYINGNDVMKLSDEMFRRLIRWRKISMVFQGAQNSLNPVLKVGFQVAEPLMIHNNMSPEEALAEAKKYLRLVGIHESFADRYPFELSGGMKQRAVIAMALITHPDIIILDEPTSALDVITQANIINLLKRIKNEMGLSYIFITHDIAVTSELADRVAVMYAGEIVEIADADEFYTNPRHPYSEKLMASVPTLRTDKKLEFIPGAPPSLINPPPGCRFHPRCPYAYERCLRENPPPFELKTGSFVKCWLYHEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ7</accession>
    <name>A1RWJ7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Adenylate kinase</fullName>
            <shortName evidence="5">AK</shortName>
            <ecNumber evidence="5 7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adk</name>
        <name evidence="9" type="ordered locus">Tpen_0167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5 7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0167"/>
    <dbReference type="EnsemblBacteria" id="ABL77577">
        <property type="protein sequence ID" value="ABL77577"/>
        <property type="gene ID" value="Tpen_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0167"/>
    <dbReference type="eggNOG" id="arCOG01046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_2"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="8">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="228" mass="25634" checksum="A008F5822EEC0167" modified="2007-02-06" version="1">MRKGLKASSASLRGMKLVFIGPPGVGKGTYAKAVSETFGIPHISTGDIFREEVKKGTELGKRVKEYLDRGLLVPDDLVIEVVRHRLLQEDCRRGYILDGFPRTIVQAEALERFSPPDWALLFHAEDSVILERLSGRRICARCGAIYHVKYMPPKIPGICDKCGGPLVQRRDDTPEVISERLKVYREQFTPIIAYYEGRGKLVRIEANEQADVVVPRVIAALKKLYNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL8</accession>
    <name>A1RWL8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0188"/>
    <dbReference type="EnsemblBacteria" id="ABL77598">
        <property type="protein sequence ID" value="ABL77598"/>
        <property type="gene ID" value="Tpen_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0188"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_8_1_2"/>
    <dbReference type="OMA" id="AMCFVKV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="142"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="737" mass="78957" checksum="0E2001D56A8200EF" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR5</accession>
    <name>RL30_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl30</name>
        <name type="ordered locus">Tpen_0235</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751910.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWR5"/>
    <dbReference type="SMR" id="A1RWR5"/>
    <dbReference type="STRING" id="368408.Tpen_0235"/>
    <dbReference type="EnsemblBacteria" id="ABL77645">
        <property type="protein sequence ID" value="ABL77645"/>
        <property type="gene ID" value="Tpen_0235"/>
    </dbReference>
    <dbReference type="GeneID" id="4600705"/>
    <dbReference type="KEGG" id="tpe:Tpen_0235"/>
    <dbReference type="eggNOG" id="arCOG04086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OMA" id="KDYITWG"/>
    <dbReference type="OrthoDB" id="79065at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000347174" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="156" mass="17763" checksum="9B5D9AD2FB3C1366" modified="2007-02-06" version="1">MALYLVIRLRGQPDRRPEEEKALELLRLHKVYHAVLVKDDPSIKGMLERTLSSAVTWGEINKETLVELLKRRGRITGNKRLTEEYLKKIGFNSFEELAEALISGKVSLEDLPGVKPVFRLRPPSGGFRGTIRRNINARGELGYRGADINNLVLRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS1</accession>
    <name>A1RWS1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14</name>
        <name evidence="4" type="ordered locus">Tpen_0241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751916.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0241"/>
    <dbReference type="EnsemblBacteria" id="ABL77651">
        <property type="protein sequence ID" value="ABL77651"/>
        <property type="gene ID" value="Tpen_0241"/>
    </dbReference>
    <dbReference type="GeneID" id="4601468"/>
    <dbReference type="KEGG" id="tpe:Tpen_0241"/>
    <dbReference type="eggNOG" id="arCOG00782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_2_2_2"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="122051at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="54" mass="6356" checksum="DA083F6EDB8A9F98" modified="2007-02-06" version="1">MAKLHPPKKRKYGKGSRRCIRCGTHEAIIRVYGLNLCRRCFREVAEEIGFKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX3</accession>
    <name>A1RWX3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0293"/>
    <dbReference type="EnsemblBacteria" id="ABL77703">
        <property type="protein sequence ID" value="ABL77703"/>
        <property type="gene ID" value="Tpen_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0293"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OMA" id="VYRMDEP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="142" mass="15762" checksum="78B69B089E64777A" modified="2007-02-06" version="1">MLRLTRPKTATLIFSSGKMVCTGAKSEAEVQKAVKSIIKLLKAHGIDIKNEPVIEVQNIVASANLKASVDLERAAFLLENSMYEPEQFPGLIYRMQDPKVVLLIFSSGKVVCTGAKKEEEVKRAVEKIYNILKEQGVLVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY0</accession>
    <name>A1RWY0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0300"/>
    <dbReference type="EnsemblBacteria" id="ABL77710">
        <property type="protein sequence ID" value="ABL77710"/>
        <property type="gene ID" value="Tpen_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0300"/>
    <dbReference type="eggNOG" id="arCOG05529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032979_0_0_2"/>
    <dbReference type="OrthoDB" id="117155at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="127" mass="14830" checksum="978D5612249B01C7" modified="2007-02-06" version="1">MLVVCVEKDIELIKRRMLLEMQKKMLAKEAKREPERINYYEVFVSHLTDDGKEMFGKALEQYGEVARKIGEKLGYLFHTGRITGSLDASTIYWIFQEAGLPIRLETRIVYKKKGEVKSISDLLKEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY6</accession>
    <name>PSB1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome subunit beta 1</fullName>
            <ecNumber evidence="1">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20S proteasome beta subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proteasome core protein PsmB 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psmB1</name>
        <name type="ordered locus">Tpen_0307</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751981.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWY6"/>
    <dbReference type="SMR" id="A1RWY6"/>
    <dbReference type="STRING" id="368408.Tpen_0307"/>
    <dbReference type="MEROPS" id="T01.002"/>
    <dbReference type="EnsemblBacteria" id="ABL77716">
        <property type="protein sequence ID" value="ABL77716"/>
        <property type="gene ID" value="Tpen_0307"/>
    </dbReference>
    <dbReference type="GeneID" id="4601710"/>
    <dbReference type="KEGG" id="tpe:Tpen_0307"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="VDKTGPH"/>
    <dbReference type="OrthoDB" id="89767at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_0000397476" description="Removed in mature form; by autocatalysis" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397477" description="Proteasome subunit beta 1">
        <location>
            <begin position="13"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <sequence length="200" mass="21578" checksum="0F6FBE7B474846DB" modified="2007-02-06" version="1" precursor="true">MSADLRDKVLKGTTTVGLVGKDFVVLAADRRATAGYFIANKQTWKIVEIDSHIAATIAGTVGDAQQLVDRLRVEARYYKTITGDSMPVKSVATLASLILFQYRPILSVQMLIGGVDSDGPSLFSVDWLGTVTREKYTATGSGSPYAVSLLEHEYREDLSLEEAVNLAVKAVNIALARDPGSGEGVDIATITKEGIRMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ7</accession>
    <name>A1RWZ7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Tpen_0318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751992.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0318"/>
    <dbReference type="EnsemblBacteria" id="ABL77727">
        <property type="protein sequence ID" value="ABL77727"/>
        <property type="gene ID" value="Tpen_0318"/>
    </dbReference>
    <dbReference type="GeneID" id="4602086"/>
    <dbReference type="KEGG" id="tpe:Tpen_0318"/>
    <dbReference type="eggNOG" id="arCOG01187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_2"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="OrthoDB" id="6307at2157"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="201"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL77727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="755" mass="83298" checksum="ABDE5DF7C4B3DB03" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX75</accession>
    <name>A1RX75_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752070.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0396"/>
    <dbReference type="EnsemblBacteria" id="ABL77805">
        <property type="protein sequence ID" value="ABL77805"/>
        <property type="gene ID" value="Tpen_0396"/>
    </dbReference>
    <dbReference type="GeneID" id="4600531"/>
    <dbReference type="KEGG" id="tpe:Tpen_0396"/>
    <dbReference type="HOGENOM" id="CLU_2505134_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="9389" checksum="DB9D34B84316A088" modified="2007-02-06" version="1">MTVSVELSLECRIVLANRAEKLCRVVRDLVEAAGEGILLVDDELAVEIVEARRAAEYLLEALKDLEAEIGKGSVIALRFHRSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA4</accession>
    <name>A1RXA4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752099.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0425"/>
    <dbReference type="EnsemblBacteria" id="ABL77834">
        <property type="protein sequence ID" value="ABL77834"/>
        <property type="gene ID" value="Tpen_0425"/>
    </dbReference>
    <dbReference type="GeneID" id="4602104"/>
    <dbReference type="KEGG" id="tpe:Tpen_0425"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_2"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="OrthoDB" id="110723at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="12454" checksum="29EB41471563BE99" modified="2007-02-06" version="1">MSCRGLPSVSHVELKGLLSEKKVVVVDFYADWCIPCKVVDDMLLRVEKLFERYDSVCFVKVNVDTEKEVAAEYDVLGLPTVIVFAAGKEVKRYTGVPRSLISDLAATVKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA7</accession>
    <name>A1RXA7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0282 protein Tpen_0428</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0282 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0428"/>
    <dbReference type="EnsemblBacteria" id="ABL77837">
        <property type="protein sequence ID" value="ABL77837"/>
        <property type="gene ID" value="Tpen_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0428"/>
    <dbReference type="eggNOG" id="arCOG00969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079268_0_0_2"/>
    <dbReference type="OMA" id="YHYDHHT"/>
    <dbReference type="OrthoDB" id="36408at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01406">
        <property type="entry name" value="UPF0282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014426">
        <property type="entry name" value="UPF0282_hydrls"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF4">
        <property type="entry name" value="PTHR43546:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004944">
        <property type="entry name" value="UCP004944_hydrls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="323" mass="36504" checksum="C4A1E6DC5DB00A9F" modified="2007-02-06" version="1">MRLGVRPIADESLGVRSMSILVETPDVKILFDASSSLAPRRYGLPPHPEEFKAQLRVREEILKAASRADVVTVSHYHRDHYSPPYASLYECLRENEYEEIYSGKVVVAKHPEELINYSQRRRAEAFLEAVRGKAKEIHLLNQGVLRFGGTEIEAFTARHGESLGYVLCFVVRVDGSPFLAFLPDVQGPVDDEVVEKILAYAPEYVVVGGPPLYLSEQKVSGEAVEKGLRNLVRLFTLTQRGTRVIVSHHMLRDPEWRDALIQRGVHEDEIETYSSLLGLPFTGLEAYRKLLFSSNPPPSDYENLLEKFKGKRCDLLLESLGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD0</accession>
    <name>A1RXD0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752125.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0451"/>
    <dbReference type="EnsemblBacteria" id="ABL77860">
        <property type="protein sequence ID" value="ABL77860"/>
        <property type="gene ID" value="Tpen_0451"/>
    </dbReference>
    <dbReference type="GeneID" id="4601854"/>
    <dbReference type="KEGG" id="tpe:Tpen_0451"/>
    <dbReference type="eggNOG" id="arCOG02914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574432_0_0_2"/>
    <dbReference type="OrthoDB" id="136617at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="458" mass="48955" checksum="CF73FEC3238DE584" modified="2007-02-06" version="1">MTVNKKALVLVAVAVLTALAAYIALLATPPAQPPVQPPTQTPAQGPAPAEKPRNATLTLKVYGPGSLLVNGTGYVNATLTLRAPAVLAINASPQPGWRLKALLVNGSPVLPGVARVSGDTTVEAVFAWSGPVVTLRVYGSGYLLVNGSSYGNDTLLLRGGALLSINASTPRSWRLKALLVNGSPTSPGDVRVYGNTTIEAFFEQVKVKVKVVPGEHPVTINGSWVNSTTVLEVPAYSVLVLGPASVELNETCEAVHYWNASVAGRWTLLHGDASLEVANDTVLVAGWSLKCHPPRSTLGGVLYAGREVKARMVLTVKEAQSGSWRYKGNGVWEIEAPGFLIVLLETPKNWSKVVVKGKPLARSGIIEILVIVENGPSMYRSKGAGLIFEDISYFEFVLPRCIMQGTCDATVNAYGSFVNEGYREHWGPRLEPPPVEPGWLEIQVYPGTHVEIQVFVEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE1</accession>
    <name>RL14E_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl14e</name>
        <name type="ordered locus">Tpen_0462</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752136.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXE1"/>
    <dbReference type="SMR" id="A1RXE1"/>
    <dbReference type="STRING" id="368408.Tpen_0462"/>
    <dbReference type="EnsemblBacteria" id="ABL77871">
        <property type="protein sequence ID" value="ABL77871"/>
        <property type="gene ID" value="Tpen_0462"/>
    </dbReference>
    <dbReference type="GeneID" id="4600989"/>
    <dbReference type="KEGG" id="tpe:Tpen_0462"/>
    <dbReference type="eggNOG" id="arCOG04167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183474_0_0_2"/>
    <dbReference type="OMA" id="RRCNIKH"/>
    <dbReference type="OrthoDB" id="118643at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00721">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023651">
        <property type="entry name" value="Ribosomal_L14e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_protein_L14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="PTHR11127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000083308" description="50S ribosomal protein L14e">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00721"/>
        </source>
    </evidence>
    <sequence length="98" mass="10809" checksum="EE19B645289FA85C" modified="2007-02-06" version="1">MKVYDVGRICVKTSGREAGLKCVIVDIIDDNFVLVTGPKSVSGVKRRRANIRHLEPLEYKISISKGASDEEVKAALEKAGLIEFMKEKVKPTVSTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK0</accession>
    <name>A1RXK0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative circadian clock protein, KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0524"/>
    <dbReference type="EnsemblBacteria" id="ABL77930">
        <property type="protein sequence ID" value="ABL77930"/>
        <property type="gene ID" value="Tpen_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0524"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_0_0_2"/>
    <dbReference type="OMA" id="HSMKKYP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="116"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="364" mass="40415" checksum="9EF48D8B8D9D672A" modified="2007-02-06" version="1">MGFDLAGMDRVARSSCIGCPLYIKSRQYCLKLKTRVADPYSPPCRVAQPAEAVQVSQATVVEATQTAVQYPQPVASVAGNAYPVAQEPYPVEEIPYTDEAYEVMSTNQALLSKRALYAPTGIPGLDEILAGGFLRGKTYLVAGEAGCGKTIFSIQFLINGALNGEPGLYIAIDEPTNQLLRGLKLFGWDLGDLISARKLMFLDMRTHFSKIYMRDERKHIEPRYIIEQILNAAKKINAKRLVIDPIAPLVYGGKEEDVLYAREFLREMVFAIEKTGELTTIMTSEIPTGSTKLSRFGVEEFLASGIIVLGIEEIYGNVERVMYIRKARWAPVKPSKYIFDIVSGKGIVIREPLSDYLARLRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM5</accession>
    <name>A1RXM5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752220.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0549"/>
    <dbReference type="EnsemblBacteria" id="ABL77955">
        <property type="protein sequence ID" value="ABL77955"/>
        <property type="gene ID" value="Tpen_0549"/>
    </dbReference>
    <dbReference type="GeneID" id="4600513"/>
    <dbReference type="KEGG" id="tpe:Tpen_0549"/>
    <dbReference type="eggNOG" id="arCOG01239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357977_0_0_2"/>
    <dbReference type="OMA" id="KCLHADH"/>
    <dbReference type="OrthoDB" id="126445at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007158">
        <property type="entry name" value="TrmY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40703">
        <property type="entry name" value="PTHR40703"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04013">
        <property type="entry name" value="Methyltrn_RNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="210" mass="22897" checksum="58056113ED1CCFE9" modified="2007-02-06" version="1">MSLEVLRELVFREKFSRVFVVFSNTAATAPVFTVSTLATLGGRMDVVARSLINALWDLESQRFNTLLVALLNGPPNPPLGLYAWRVPAGGKRSEGFFGGLILEALSGKKVDGLLVEKGARLVDVVSLLKGAGYPVYLLDENGLSYANVNLEEPVAFVLGDHIGIPADLLRQVTRLVDGVISIGRTPYLTSHCIAFVHELLDRSSRLRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN1</accession>
    <name>A1RXN1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752226.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0555"/>
    <dbReference type="EnsemblBacteria" id="ABL77961">
        <property type="protein sequence ID" value="ABL77961"/>
        <property type="gene ID" value="Tpen_0555"/>
    </dbReference>
    <dbReference type="GeneID" id="4600519"/>
    <dbReference type="KEGG" id="tpe:Tpen_0555"/>
    <dbReference type="eggNOG" id="arCOG00048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032119_0_0_2"/>
    <dbReference type="OMA" id="WFDSTKL"/>
    <dbReference type="OrthoDB" id="47556at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="336" mass="37765" checksum="2F8B4258529FB576" modified="2007-02-06" version="1">MKEVRILATTVQGLEWFVCEELREICGEVRVFSAREGSGRVIAEIDERCLAILMEKARSVEKVYLFFGEAASIEEAGIDLSEKLREFSGFFRFFSVHAERITKDIDLTSLEIAAKIGEMVKTRLNLDVSLDFPDIPVYVEYEKGVYRYGVDLCFHRSLRDRPYRRFIHRSALNPLIAYALCRAVRGGKSLWDPFCGSGTIPLECLEVYPWARAVCSDVNAEFIAGALQNSLAVGKELDLVVSDIRSAPLRSGSIDAVVTNPPFGIREKAVGGLRKVYEALFTEASRVLVQGGRLAVLTPHRKLVESLAQKHSFLKVGEWRLNEGGLLSYMLLYSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP9</accession>
    <name>A1RXP9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752244.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0574"/>
    <dbReference type="EnsemblBacteria" id="ABL77979">
        <property type="protein sequence ID" value="ABL77979"/>
        <property type="gene ID" value="Tpen_0574"/>
    </dbReference>
    <dbReference type="GeneID" id="4600618"/>
    <dbReference type="KEGG" id="tpe:Tpen_0574"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="ATGCMEV"/>
    <dbReference type="OrthoDB" id="29720at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="51"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="311" mass="34708" checksum="A338AB38BAC524D1" modified="2007-02-06" version="1">MELKTIKTLKEIPREEQFAPGHRLCAGCGIPQVVRLALKAVPDPKVVVNATGCLEVATTIFPYTSWGVPWVHIAFENAAAVASGIEAAFKILSKKYGVEKPKIIVFGGDGGTFDIGFQALSGALERGHDMIYICYDNEAYMNTGIQRSGATPKGASTTTSPAGKVVPGKLERKKNLIEIAIAHGIRYAATMNPAFPVDMYNKIVKAANTPGPTVLHYFTPCPTGWYFDPSRSIEVARLAVQTRIWPLYEYDNGKIRITVPVKEPRPVEDYFKLQGRFRHLLEPENKWLLEEIKRDIEENWQKLMRMAEQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU3</accession>
    <name>A1RXU3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA intron endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0619"/>
    <dbReference type="EnsemblBacteria" id="ABL78023">
        <property type="protein sequence ID" value="ABL78023"/>
        <property type="gene ID" value="Tpen_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0619"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OMA" id="KGPGIDH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="79"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19817" checksum="D65F504E5919C112" modified="2007-02-06" version="1">MVVLDPLQGNQLYFKGGFYGRFFTVPKPKLPDVRKELELSLFDAMYLLEQGCLDLKREDGSPVSPSELFELASRIYENFYDAYAVYKDLRGRGYVVKSGMKFGSTFAVYQFGPGIDHSIFLVDVLKYNDKLDPIQIIRAGRLSHSVRKHFILAYRDPVDGKIQYFSFRWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX4</accession>
    <name>A1RXX4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III restriction enzyme, res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752319.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0652"/>
    <dbReference type="EnsemblBacteria" id="ABL78054">
        <property type="protein sequence ID" value="ABL78054"/>
        <property type="gene ID" value="Tpen_0652"/>
    </dbReference>
    <dbReference type="GeneID" id="4601610"/>
    <dbReference type="KEGG" id="tpe:Tpen_0652"/>
    <dbReference type="eggNOG" id="arCOG00876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421288_0_0_2"/>
    <dbReference type="OrthoDB" id="36907at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="280"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="455"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="458"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="630" mass="72379" checksum="655B3C3F94B6EEB1" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX7</accession>
    <name>A1RXX7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752322.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0655"/>
    <dbReference type="EnsemblBacteria" id="ABL78057">
        <property type="protein sequence ID" value="ABL78057"/>
        <property type="gene ID" value="Tpen_0655"/>
    </dbReference>
    <dbReference type="GeneID" id="4601613"/>
    <dbReference type="KEGG" id="tpe:Tpen_0655"/>
    <dbReference type="HOGENOM" id="CLU_182725_0_0_2"/>
    <dbReference type="OrthoDB" id="140788at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035954">
        <property type="entry name" value="MTH677-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="97" mass="11536" checksum="639D2A614EA848EE" modified="2007-02-06" version="1">MRGRSKREDLEELERVSMLVLEEMYRELQEALSEDPELQLTIKVEVDEDWPYDFRLDVEVSSKLYDKKTLEDTLNRVVSKYLKKAEEELRKAGLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX9</accession>
    <name>A1RXX9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0657"/>
    <dbReference type="EnsemblBacteria" id="ABL78059">
        <property type="protein sequence ID" value="ABL78059"/>
        <property type="gene ID" value="Tpen_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0657"/>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385726_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="658" mass="73864" checksum="9134FDB1D50FE719" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ1</accession>
    <name>A1RXZ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752336.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0669"/>
    <dbReference type="EnsemblBacteria" id="ABL78071">
        <property type="protein sequence ID" value="ABL78071"/>
        <property type="gene ID" value="Tpen_0669"/>
    </dbReference>
    <dbReference type="GeneID" id="4601035"/>
    <dbReference type="KEGG" id="tpe:Tpen_0669"/>
    <dbReference type="eggNOG" id="arCOG01815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753597_0_0_2"/>
    <dbReference type="OrthoDB" id="138802at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="366" mass="40080" checksum="ADEF8E0C07B02040" modified="2007-02-06" version="1">MLEDLELLLLLSYTEAPPSHVFKWLEEHGYSYKASRSLLEAARSDEESGSRHALRTILGEKVSRLETKLETFSRKSESLAEIFSITLLSAPLMLYSLALFNPRMVAPLTLALMTLNAVIIFTYSSVYPRELRALKVGPIQVILAALPFASLALLSLPPALVLAALAAFSLPGFLYNFTLVTRVQRELRENLELLVRVASAPFHAFKTVKPEKLLAGKFVSNLTPSVRLSLFLSAYWGTDREAMLGLKNTYEKILRILHSLQARALLNGLTNLVGLFLLGFASSLISQLLESIARVELLQSVGVPADVRGLEQWFLAYLLFACMAYSGGISALSFGTPLLLPLWLPAAALAALAGLSAGRNLVIIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY23</accession>
    <name>A1RY23_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0701"/>
    <dbReference type="EnsemblBacteria" id="ABL78103">
        <property type="protein sequence ID" value="ABL78103"/>
        <property type="gene ID" value="Tpen_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0701"/>
    <dbReference type="eggNOG" id="arCOG04054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399804_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="221" mass="25621" checksum="9DD3C29ECEDAE6D6" modified="2007-02-06" version="1">MNVICTSFPFANNLPREYVLKSPLKHMTFEEVMRGIVLSEITDRKLLEKIVGKVVYRRSGEKVGKIWKIYVSKREKQPIKVVLKTDSNGKIVVPPERIRVENNRIILLDHSQEAILSIIGRLSDIAEELRKLRDELLVLDEKLISGEIPREEYNVARSRIERKKVHLRMEASTLLDALNHMVQSGEVTLNKEEERRIYEIMDVLSLSLPAIPLRELEKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY51</accession>
    <name>A1RY51_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0729"/>
    <dbReference type="EnsemblBacteria" id="ABL78131">
        <property type="protein sequence ID" value="ABL78131"/>
        <property type="gene ID" value="Tpen_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0729"/>
    <dbReference type="HOGENOM" id="CLU_168732_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="116" mass="13185" checksum="570A38E69D07B2E5" modified="2007-02-06" version="1">MRKAFLRVRKEAWVRIDMSSDGSLCMVEGCSAGADILLEVRGQQLLLCKTHFKDLVSRLAKAAEKEGKASLLRLKVQKTSDGKVRLLIRRKVSRATKKSERKTRKKSRKKGKSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY63</accession>
    <name>A1RY63_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0741"/>
    <dbReference type="EnsemblBacteria" id="ABL78143">
        <property type="protein sequence ID" value="ABL78143"/>
        <property type="gene ID" value="Tpen_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0741"/>
    <dbReference type="eggNOG" id="arCOG03773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544272_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="18578" checksum="84EEC7D7921B3457" modified="2007-02-06" version="1">MCWFSFILAVSLGYDELAPVYEELYGAEQYKKNLAASSALKGLPVVLDAGCGTGILSEFLGGSYYVCLDSSRGMLEVFRARRRCFCDAVQADMQLPPFRELAFDGVACVTAVHEAPGALGVLAGLVKAEGVLVVSVKERLLPGGLEVPGWLVLEGVVESSGDAVYFYRRRGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY83</accession>
    <name>A1RY83_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752428.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0761"/>
    <dbReference type="EnsemblBacteria" id="ABL78163">
        <property type="protein sequence ID" value="ABL78163"/>
        <property type="gene ID" value="Tpen_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="4601082"/>
    <dbReference type="KEGG" id="tpe:Tpen_0761"/>
    <dbReference type="eggNOG" id="arCOG04264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792231_0_0_2"/>
    <dbReference type="OrthoDB" id="112709at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="141" mass="16252" checksum="096850FF19AC73A1" modified="2007-02-06" version="1">MSYSLYQFNGFGELLKYLDSQIESLQKTLEQLEQRYEAVKVRAEKMREIERVLEELMGEKLSPLNEVDYMGLKLVINARAIDELAVLEETIESQRDILDSLVNVRDAIQKLSEHLQGYDGIPILVQLVNGVPVRILLKETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY84</accession>
    <name>A1RY84_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">Tpen_0762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0762"/>
    <dbReference type="EnsemblBacteria" id="ABL78164">
        <property type="protein sequence ID" value="ABL78164"/>
        <property type="gene ID" value="Tpen_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0762"/>
    <dbReference type="eggNOG" id="arCOG01532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_2_0_2"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="268" mass="31979" checksum="5CCDA7E5352A2488" modified="2007-02-06" version="1">MCTRVVGMWRRLAERLGVYRLYEYLLDREVRGGEIPRHVAFILDGNRRWARRRGFPPWMGHRFGAEKVDEVLDWCYDLGVVTVTLYVLSTENLERRSKEELENIFGILREKIDELASSEELHRRQVRVKFIGDIKRLPVDIQEKMRELEERTRSYNKRYLNIAVAYGGRHEILEAVRQIAVEVRSGRLSPEEIDEKLFAKYLYTGDEPHPEPDLVIRTSGEVRISNFLLWQIAYSELVFLDVYWPDFRRIDFLRAIRTYQSRQRRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC2</accession>
    <name>A1RYC2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752467.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0800"/>
    <dbReference type="EnsemblBacteria" id="ABL78202">
        <property type="protein sequence ID" value="ABL78202"/>
        <property type="gene ID" value="Tpen_0800"/>
    </dbReference>
    <dbReference type="GeneID" id="4601261"/>
    <dbReference type="KEGG" id="tpe:Tpen_0800"/>
    <dbReference type="eggNOG" id="arCOG04105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902051_0_0_2"/>
    <dbReference type="OrthoDB" id="124357at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="130" mass="14436" checksum="6D2C732521B00AF0" modified="2007-02-06" version="1">MSSKLDARERKLLYLLQVYGRPISRKALHRLVRIVQEKYGVDMGFSFSQDAAFSKELDAVLQKLAEEDYVKVLYAAGGRFLTLYKPLYALGKRGAAALSKKELAKTDAEKLEKAVAEVLGRGQGVEAPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE7</accession>
    <name>A1RYE7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752492.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0826"/>
    <dbReference type="EnsemblBacteria" id="ABL78227">
        <property type="protein sequence ID" value="ABL78227"/>
        <property type="gene ID" value="Tpen_0826"/>
    </dbReference>
    <dbReference type="GeneID" id="4601829"/>
    <dbReference type="KEGG" id="tpe:Tpen_0826"/>
    <dbReference type="eggNOG" id="arCOG00768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623516_0_0_2"/>
    <dbReference type="OMA" id="VMIHEAD"/>
    <dbReference type="OrthoDB" id="83997at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="3">
        <location>
            <begin position="261"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="49243" checksum="89440EA3CFEB9F31" modified="2007-02-06" version="1">MKRGPFPIYNNRIYGVANTQLTPENMAELGAVLGTILGEGALVVAARDLYPPSRMLKRAFTSGLMSTGNSVIDFHAATLPELAFAVKRFGAKAGVHFSVAPYNTDGIQVKIVDAGGVELSYEKLADILDMYETKHIVRSIPSRIGWISYAEYIHDIYVTSAASFIDTSPIAAKEPLVIVDVNYGPASDVLPNFVGSLGARLVAVKAGRPPPGVRPQQLPSPRDIAMLQDITRASSPAFAAALSADASQVFIVDDKGRIVDPDKLVAAVALMLPEGARIAVSDSAGRIVDVAAEKNKLYLLRVKGLAGDVARGVKKIKAGIAATDSGEFIFPQFSYSPDGMLFIGKLLELLSTQEVRLSTIIETLPEMREYTLEIDLEEQRSRRVLEYIFSLFSEFALSPLSIKYRADGVWVKLTYDYEREKLLVSGDAENKHAIEAVKKEFERLNELVSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH4</accession>
    <name>A1RYH4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ordered locus">Tpen_0853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752519.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0853"/>
    <dbReference type="EnsemblBacteria" id="ABL78254">
        <property type="protein sequence ID" value="ABL78254"/>
        <property type="gene ID" value="Tpen_0853"/>
    </dbReference>
    <dbReference type="GeneID" id="4601978"/>
    <dbReference type="KEGG" id="tpe:Tpen_0853"/>
    <dbReference type="eggNOG" id="arCOG04174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_3_0_2"/>
    <dbReference type="OMA" id="HRCLQMT"/>
    <dbReference type="OrthoDB" id="36053at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="52"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="41792" checksum="657A8068F2F1B5B7" modified="2007-02-06" version="1">MSVSPMQEAQRLDVARYLRAGYKLVGNHSAVAVCRWTRSALRGERLCYKSWYGIQSHRCLQMTPVLNFCDFACKFCWRMHLPGRFKLPPGWRWDEPEDIINGSIVAQRLLLIGFKGNPKVSRERFLEAMFPRHFTISLDGEPSLYPKLAELVKKVKERNFTAFLVTNGSIPIRLEELVKRDAQPTNLYLSLYGPNKEVFTATADPRIPNAWENVLRSLELLDRFTESRTVLRLTMVKDLNMVDPEGYSKLIKLGNPMFVELKGYTWVGESQKRLPISAMPTIEELEKFAKKLEELTGYKVKVEDDKSRVVMLVRDEDVWERNLKMVEEWRARVAKLDESWRSKVEDFTMEEHGKILYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ0</accession>
    <name>A1RYJ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0869"/>
    <dbReference type="EnsemblBacteria" id="ABL78270">
        <property type="protein sequence ID" value="ABL78270"/>
        <property type="gene ID" value="Tpen_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0869"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OMA" id="YLIMLAK"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="104" mass="11628" checksum="D165792375E745E0" modified="2007-02-06" version="1">MPAGRVRTVTYLIMLAKVMFRESMSSQNKITVFLLVNVGVGREDDVLKAIRSMEFVEEAYIVYGEYDIVAKISLPALELLDKVVTNIRKLGGVTRTSTLITSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ6</accession>
    <name>A1RYJ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0875"/>
    <dbReference type="EnsemblBacteria" id="ABL78276">
        <property type="protein sequence ID" value="ABL78276"/>
        <property type="gene ID" value="Tpen_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0875"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OMA" id="FIDINPV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="179" mass="20068" checksum="0D0C8EAFE22435B2" modified="2007-02-06" version="1">MVYEPREDTFLLLDCLKRGFRGGVLVEVGCGKGVVSVYASNRADYVVGVDIAWEAVRLSRELARASKECLVDFVQADMLNPFRDSSADVVASNPPYLPCDYREDPLVCGGEDGVEFSARLAREAFRVLRRSGELFLVASSISNFERLLDVLRGLYASVEVAEERRLFFEKLFCLRALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL2</accession>
    <name>A1RYL2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mevalonate kinase</fullName>
            <shortName evidence="10">MK</shortName>
            <shortName evidence="10">MVK</shortName>
            <ecNumber evidence="2 10">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mvk</name>
        <name evidence="13" type="ordered locus">Tpen_0891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2 10"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752557.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0891"/>
    <dbReference type="EnsemblBacteria" id="ABL78292">
        <property type="protein sequence ID" value="ABL78292"/>
        <property type="gene ID" value="Tpen_0891"/>
    </dbReference>
    <dbReference type="GeneID" id="4600467"/>
    <dbReference type="KEGG" id="tpe:Tpen_0891"/>
    <dbReference type="eggNOG" id="arCOG01028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OMA" id="NTVCTYG"/>
    <dbReference type="OrthoDB" id="90882at2157"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="12">
        <location>
            <begin position="229"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="34207" checksum="ED9A567A19FFEE17" modified="2007-02-06" version="1">MQATRSSAPAKVILFGEHFVVEGQPAIAAAISLRAHVTVEPADTDGILVYSKNLGLLEEYRFAERGAWSGKMLSIAIAAYTAMESLGRKSGVKVTVDSEIPPGSGMGSSAAVAVATTHATFRAFGEEPDLKEVSRIAFEAEKVVHGKPSGIDNTVATYGGVIAYRKGEGFIPLKAELNGVRLVLADSGVPRNTGEMVKRVLELKNTYPSVLEPLYHAAGRLVVEAARRLEEGDYESLGRLMNVNHGFLSAIGVSTLELEKLVYTARRAGALGSKLTGAGGGGFIVALVTAEKEKEVVEALRQLSPRIFSVEISSEGVRKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN4</accession>
    <name>A1RYN4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752579.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0913"/>
    <dbReference type="EnsemblBacteria" id="ABL78314">
        <property type="protein sequence ID" value="ABL78314"/>
        <property type="gene ID" value="Tpen_0913"/>
    </dbReference>
    <dbReference type="GeneID" id="4602126"/>
    <dbReference type="KEGG" id="tpe:Tpen_0913"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="361" mass="40289" checksum="408B113DBF48F161" modified="2007-02-06" version="1">MAKGVSLQVVDVWKTYRDRGRTEALRGVTLEVERGELFSILGPSGCGKTTLLRIIAGLSAPDRGKVFFDGVDVTGLPAYERDIGMVFQDLALFPHLTVYKNVAFSLELAGVPREVAERRVREVLELVHLPFEVFAHRKIQQLSGGQQQRVAIARALARDPRLLLLDEPFSHLDYKVRLELIKELKRLQRETGVTTVYVTHDQNEAMMLSDRLALMKDGVVLQVGRPDEVYRKPANAFVASFLGESNLVRLRAVGGVAEFRGARLDLSLLSEEYKGYTGEVTLFVRPEHVSLHPPPHGRYIEVEAVVVDRVFLGPLTKVVLDGLGDAAFEALFPSRDASGLEERAPVKVYIDLSETRVFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP0</accession>
    <name>A1RYP0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752585.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0919"/>
    <dbReference type="EnsemblBacteria" id="ABL78320">
        <property type="protein sequence ID" value="ABL78320"/>
        <property type="gene ID" value="Tpen_0919"/>
    </dbReference>
    <dbReference type="GeneID" id="4600815"/>
    <dbReference type="KEGG" id="tpe:Tpen_0919"/>
    <dbReference type="eggNOG" id="arCOG05475">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668387_0_0_2"/>
    <dbReference type="OrthoDB" id="41812at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="411" mass="45721" checksum="638AD253F9F9EDDF" modified="2007-02-06" version="1">MEATLEYLALGVLIVLLIAVAYGMASTSMNTLGTVYEEQLFTVAERVMDKIVLTPGYPADWGTNISVTPDTLTDFGLALAGTRTPYVVDPDKVMRLANLSTLPNPLLLNASRLAQLLGLSENYGFRLRMRPMLVVSVKPVAYRQFGNWNFSSIFQVNVTNYYGLGIPNANVTGMYVIVRVNPGNGEVEKKQVFAKSNLTGPLGTCTLDYRSELSNYFNKQRTDRWFFAFLILRAEWQGFVSVAGYAPTAQRGVPVEGYIIGKYIFVDRTIEVGKTSGAVHVKDELLQAVPEYQNLLNFTTVVWCRDSTGNFRNDDPLCNNAGKVLPSAKQWYLVGYVKYVEPLSSHIFVFAQFRGSPVVIVVNRIPSIDISYGGSKAQPANSVTLGPRICTIYSYPYVVELTIWRRVEGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP5</accession>
    <name>A1RYP5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752590.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0924"/>
    <dbReference type="EnsemblBacteria" id="ABL78325">
        <property type="protein sequence ID" value="ABL78325"/>
        <property type="gene ID" value="Tpen_0924"/>
    </dbReference>
    <dbReference type="GeneID" id="4600820"/>
    <dbReference type="KEGG" id="tpe:Tpen_0924"/>
    <dbReference type="eggNOG" id="arCOG00535">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_9_4_2"/>
    <dbReference type="OrthoDB" id="143416at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="73" mass="7849" checksum="8BBD7C0AC1C23B1F" modified="2007-02-06" version="1">MGVEEYVSVEVDVFGREVRKVEVPRGSTLRDLVTTLGLRVSEVVVTVDGEVVAEDEPVKPGTRVKLHSVVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ7</accession>
    <name>A1RYQ7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0937"/>
    <dbReference type="EnsemblBacteria" id="ABL78337">
        <property type="protein sequence ID" value="ABL78337"/>
        <property type="gene ID" value="Tpen_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0937"/>
    <dbReference type="eggNOG" id="arCOG05744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582974_0_0_2"/>
    <dbReference type="OMA" id="SLCVQIC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="17323" checksum="B2A8C5E91704BFE6" modified="2007-02-06" version="1">MFRRSGVVSAGELESMGLVPPRERLIRGAVAVTECIEEIPCNVCESACPVKAIRVEGLRGRPRIDWDRCTGCGVCVGVCPGQAMFLLDLSRGAAVTVPYEFLPRLRRGDTVELLDREGRVVGEGTVIRVFEVNKTQVVTVSVPENLLMEVRAVRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ9</accession>
    <name>A1RYQ9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752604.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0939"/>
    <dbReference type="EnsemblBacteria" id="ABL78339">
        <property type="protein sequence ID" value="ABL78339"/>
        <property type="gene ID" value="Tpen_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="4601068"/>
    <dbReference type="KEGG" id="tpe:Tpen_0939"/>
    <dbReference type="eggNOG" id="arCOG14878">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792225_0_0_2"/>
    <dbReference type="OrthoDB" id="138408at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="144" mass="16171" checksum="45638A03CA336B9B" modified="2007-02-06" version="1">MYVKIDIDKIKERFAGELARLLREGYTLKYAVALAVAESLKGYDWVRGVYYSEISLGEFVEGECIDGRDVDVLVETRIGVKSLSSRLEAELEEAFNEVLSSLAPRESRHKLLEVHVDDVYVRAVASAARLGKTPHNALPLFARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYR2</accession>
    <name>A1RYR2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752607.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0942"/>
    <dbReference type="EnsemblBacteria" id="ABL78342">
        <property type="protein sequence ID" value="ABL78342"/>
        <property type="gene ID" value="Tpen_0942"/>
    </dbReference>
    <dbReference type="GeneID" id="4601071"/>
    <dbReference type="KEGG" id="tpe:Tpen_0942"/>
    <dbReference type="eggNOG" id="arCOG00610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926289_0_0_2"/>
    <dbReference type="OMA" id="PKGGYKA"/>
    <dbReference type="OrthoDB" id="89519at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016436">
        <property type="entry name" value="UCP005063_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005063">
        <property type="entry name" value="UCP005063_CBS_MJ1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="177"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="307" mass="33316" checksum="ADE981E2953F6EF4" modified="2007-02-06" version="1">MDIPRNLFEILVAVVNAYEATGRPVTSSEIAEAVGKSDGTVRNVISALKAMGLVEAKTGPGGGYVPTVKGVEAVKGSLALDKLWEPQRLVVDGRVSRLYVVELDLLALSGPGAKAVLKVAGSMHQVRRGSQVILGPTGGTRLIIHGRVQDVNPARRELLVEVDSMVAVPRLRARDVMTPRPERATRGMSMREVARLIVSRNIRALPVVDEEGVLEGLVSAQHVSKAYADGRLDARVEDYMDRDVATVEPDEDILRIMRIMVERNAGRVVVVDQSGRPQGIITRTDILMALTRLYEVADSFAVQELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS3</accession>
    <name>A1RYS3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752618.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0953"/>
    <dbReference type="EnsemblBacteria" id="ABL78353">
        <property type="protein sequence ID" value="ABL78353"/>
        <property type="gene ID" value="Tpen_0953"/>
    </dbReference>
    <dbReference type="GeneID" id="4601293"/>
    <dbReference type="KEGG" id="tpe:Tpen_0953"/>
    <dbReference type="eggNOG" id="arCOG00732">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091423_0_0_2"/>
    <dbReference type="OMA" id="ADPLIFH"/>
    <dbReference type="OrthoDB" id="131688at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="12016" checksum="B4ADE8A30E5D3F6E" modified="2007-02-06" version="1">MGEEGEELAELLGGVDPFLMNYKRFAIVTLLYAVGPMTVGELKRALGFSWGDLDSKLRSLEERGYVSARKVLTLAGPRTLVELTEKGVRAYEELRARLRSALDAAGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT7</accession>
    <name>A1RYT7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0967"/>
    <dbReference type="EnsemblBacteria" id="ABL78367">
        <property type="protein sequence ID" value="ABL78367"/>
        <property type="gene ID" value="Tpen_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0967"/>
    <dbReference type="HOGENOM" id="CLU_2857301_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="64" mass="7494" checksum="9BB59CCA1D3CB1A5" modified="2007-02-06" version="1">MKVLRWLKEILGGSQPEGARFSEKATMELYRMERLQLAVQLSYIYNWQLTMHAVKALQARKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ91</accession>
    <name>A1RZ91_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysulphide reductase, NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752786.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1123"/>
    <dbReference type="EnsemblBacteria" id="ABL78521">
        <property type="protein sequence ID" value="ABL78521"/>
        <property type="gene ID" value="Tpen_1123"/>
    </dbReference>
    <dbReference type="GeneID" id="4602018"/>
    <dbReference type="KEGG" id="tpe:Tpen_1123"/>
    <dbReference type="eggNOG" id="arCOG02027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045348_1_0_2"/>
    <dbReference type="OMA" id="QFNSVMS"/>
    <dbReference type="OrthoDB" id="29739at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="292" mass="31377" checksum="47536FA0F14D6B6D" modified="2007-02-06" version="1">MMFQEVWNPVIIGLFLWFAGIAGMGSVAYALMKLGKVEEKTKELSCVVFASIVLALVFVVADLSRPLNMPLAIIRSVLSGTFFYKLSTSWMTIGISLLSILLLLALLVLLRETVAKGLQKIVDAKWYLVLTGFVGFMVVIYSGFLIADAPGVPFWNNSLIPVLWILSASICAIAVLKILVHKPEVSNFLTKSGLAVDIAEAVALASLLNVSLYSGVEAARRSAEALVAGELAAAFWLLVVLVGVAVPMVLGFMLLRKEDRRLALLAAACALVGALALRILVLQAGIFLELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC1</accession>
    <name>A1RZC1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosidase, PH1107-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1153"/>
    <dbReference type="EnsemblBacteria" id="ABL78551">
        <property type="protein sequence ID" value="ABL78551"/>
        <property type="gene ID" value="Tpen_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1153"/>
    <dbReference type="eggNOG" id="arCOG04084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796408_0_0_2"/>
    <dbReference type="OMA" id="FEYKVGW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="38760" checksum="189CE6E922AFE07A" modified="2007-02-06" version="1">MKAKILSAGDPLSKLLAEKVGRRAELRGLRRGLEQDVFERLAYITPIRVEVTNYARRPVAVFNPGAALEGSNVAIFPRMVFDYYWYVSSVGRIRVGVDDLLSGSIPGTLKADLVIYPSEEWELRGCEDPRVYGADGNYLVLYTGVLPLQNGVLPLQAVARYSEGRVEKLGYLAFEYGGERYVAPWKDSAILSEGGGEALALVRPSVPVPGGFLEAGWFTRFDLAGLTVDPGEAVPLLVAESFEYKVGWSTNALKLSSGEYLVGWHGVGVDNVYRNGLAVVSEEGELLELSEYLLVPRKSLEEFYGDRPGVVFGCGLLRIKEKLVWVGGVSDYAVGVFAVDMDKALEHLKRVSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC5</accession>
    <name>PYRB_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="1">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate transcarbamylase</fullName>
            <shortName evidence="1">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrB</name>
        <name type="ordered locus">Tpen_1157</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752820.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZC5"/>
    <dbReference type="SMR" id="A1RZC5"/>
    <dbReference type="STRING" id="368408.Tpen_1157"/>
    <dbReference type="EnsemblBacteria" id="ABL78555">
        <property type="protein sequence ID" value="ABL78555"/>
        <property type="gene ID" value="Tpen_1157"/>
    </dbReference>
    <dbReference type="GeneID" id="4602159"/>
    <dbReference type="KEGG" id="tpe:Tpen_1157"/>
    <dbReference type="eggNOG" id="arCOG00911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="51351at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000321193" description="Aspartate carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <sequence length="315" mass="34898" checksum="BC4419A6C15754AF" modified="2007-02-06" version="1">MVSGLGSRGNPFYGRDVLSILDFSRSDLEYLFAEADRVRRDPSAFSGELRGYVLATAFFEPSTRTRLSFQAAMLRLGGSCIDLGELEKSSIAKGENFADTVRMLDAYADVIVVRHRLEGAARFAAEVAEKPVINAGDGKRHHPTQAMLDLYSVKTLKGSVDGLVYGVLGDLKYGRAAASFILGLSLFKPRKVYLISPGLLKAREDVKEALRERGVGFEEVESPSEVIGELDVLYVTRIQRERFPDPSEYEKVRGSYVVDSKLLRNAKEGLIVLHPLPRVDEISFDVDGTPHAKYFEQARLGIPLRMALLKLVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD1</accession>
    <name>A1RZD1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Tpen_1163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752826.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1163"/>
    <dbReference type="EnsemblBacteria" id="ABL78561">
        <property type="protein sequence ID" value="ABL78561"/>
        <property type="gene ID" value="Tpen_1163"/>
    </dbReference>
    <dbReference type="GeneID" id="4601177"/>
    <dbReference type="KEGG" id="tpe:Tpen_1163"/>
    <dbReference type="eggNOG" id="arCOG00063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="14061at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL78561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="555" mass="62078" checksum="4AA61B9C6CB65D2E" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF6</accession>
    <name>A1RZF6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752851.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1188"/>
    <dbReference type="EnsemblBacteria" id="ABL78586">
        <property type="protein sequence ID" value="ABL78586"/>
        <property type="gene ID" value="Tpen_1188"/>
    </dbReference>
    <dbReference type="GeneID" id="4600433"/>
    <dbReference type="KEGG" id="tpe:Tpen_1188"/>
    <dbReference type="eggNOG" id="arCOG06987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187350_0_0_2"/>
    <dbReference type="OMA" id="EFRDEQI"/>
    <dbReference type="OrthoDB" id="129262at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="88" mass="9714" checksum="0093B5CA47EAB3D9" modified="2007-02-06" version="1">MRKVKTSITVDSELWEEFKSRVGSERGLRALSRAIEEALEEEVSDVLVVKALEKLLGEGEVPLDVTPVKPRVATNAGEAVRELRGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG5</accession>
    <name>A1RZG5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752860.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1197"/>
    <dbReference type="EnsemblBacteria" id="ABL78595">
        <property type="protein sequence ID" value="ABL78595"/>
        <property type="gene ID" value="Tpen_1197"/>
    </dbReference>
    <dbReference type="GeneID" id="4600389"/>
    <dbReference type="KEGG" id="tpe:Tpen_1197"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118254_0_0_2"/>
    <dbReference type="OMA" id="VGWWIIN"/>
    <dbReference type="OrthoDB" id="123316at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="27926" checksum="79CFE519C10D3BC7" modified="2007-02-06" version="1">MFELSLPWGFANLLLFLASIALTVVAGYLFSVVVRKSLGKINPLLSEIISRYGSWTIYVVGLLVSLELLNLRLETVLVFTALLGALVILGLKDVLPSIFARQFLEMYKPFRVGDWIRVGDTCGRVIDVNDLYTVVFTSSHEKLYIPNSRLLQERVYNLTAGTGFYVDVDFAASPSEGLDQLLRKVKGAIEEEAKEEGLEEPEIFVVGLEPDAVYLRVRVRVLNPQRKDEVRSRLLRRVYKAVRATRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ2</accession>
    <name>A1RZJ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1224"/>
    <dbReference type="EnsemblBacteria" id="ABL78622">
        <property type="protein sequence ID" value="ABL78622"/>
        <property type="gene ID" value="Tpen_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1224"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088214_0_0_2"/>
    <dbReference type="OMA" id="RDFNLQA"/>
    <dbReference type="OrthoDB" id="88788at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="260" mass="29084" checksum="54944DF1AF64C057" modified="2007-02-06" version="1">MEVRLDGIRGGLLIALRDLDRFWKYKFWLGAQVAMNLADILIFAVIFNNIVNRQYIPDYVKFLATGVLALSTFASAFSIGREVGIEIRREFTHYLLSIPVSREALVFGRILSGTLRGLIYQASFIVLAALIVGTPTALGAVLVLSTSAMLSASMSSLAIAISTSTRDFNLQATFRSLTYYVLFFFSNVFYPEEILKQRFPGAVVFLIKLSPVSLAADVYRWAFGYNTSINVFHEYALLLAWTLVTLVLASALYLRNLTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ6</accession>
    <name>A1RZJ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752891.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1228"/>
    <dbReference type="EnsemblBacteria" id="ABL78626">
        <property type="protein sequence ID" value="ABL78626"/>
        <property type="gene ID" value="Tpen_1228"/>
    </dbReference>
    <dbReference type="GeneID" id="4601725"/>
    <dbReference type="KEGG" id="tpe:Tpen_1228"/>
    <dbReference type="eggNOG" id="arCOG01357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="GPAAWQW"/>
    <dbReference type="OrthoDB" id="5945at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="212"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="515" mass="58546" checksum="9C0A50FED68AA9F0" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ7</accession>
    <name>A1RZJ7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752892.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1229"/>
    <dbReference type="EnsemblBacteria" id="ABL78627">
        <property type="protein sequence ID" value="ABL78627"/>
        <property type="gene ID" value="Tpen_1229"/>
    </dbReference>
    <dbReference type="GeneID" id="4601726"/>
    <dbReference type="KEGG" id="tpe:Tpen_1229"/>
    <dbReference type="HOGENOM" id="CLU_2366379_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="95" mass="9965" checksum="85125457C22DB8FA" modified="2007-02-06" version="1">MDLTVVVDASNGVDAKSLSSALFRAIRGKRAGRVRILVKGGEAPLHMEVLKDFLSNNIAVGVEVYPAEEWRGPLGDCVELKVGAGGVESSPCVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM1</accession>
    <name>A1RZM1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752916.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1253"/>
    <dbReference type="EnsemblBacteria" id="ABL78651">
        <property type="protein sequence ID" value="ABL78651"/>
        <property type="gene ID" value="Tpen_1253"/>
    </dbReference>
    <dbReference type="GeneID" id="4600419"/>
    <dbReference type="KEGG" id="tpe:Tpen_1253"/>
    <dbReference type="eggNOG" id="arCOG02109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_0_2"/>
    <dbReference type="OMA" id="VHRYWEV"/>
    <dbReference type="OrthoDB" id="112900at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="142" mass="15699" checksum="C2E351B52B681882" modified="2007-02-06" version="1">MSSGELSAEDKALVRKVLYEVEQALGVLRLCAERGVRDLADAFALRYAVIQVVEGLAVIASRLAELRGTVVEGYVEAMSFLARAGIVDPAVGEELVRLARLRNLLVHRYWEVSDEKILEEARKSGVKTVEEAVKSVRRFVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM9</accession>
    <name>A1RZM9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid protein Alba</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1261"/>
    <dbReference type="EnsemblBacteria" id="ABL78659">
        <property type="protein sequence ID" value="ABL78659"/>
        <property type="gene ID" value="Tpen_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1261"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alba" evidence="1">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="95" mass="10432" checksum="67FD22F187380492" modified="2007-02-06" version="1">MGEEVLLVGEKPESAYTLELMTMLGKGAPRVVVRAVGRNISKAVYVTEGVRRLTGDKIAYGKIRIYSTEVGEVKEEKSVPVIEIEVVNLGVERRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN3</accession>
    <name>CAPPA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="1">PEPC</shortName>
            <shortName evidence="1">PEPCase</shortName>
            <ecNumber evidence="1">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppcA</name>
        <name type="ordered locus">Tpen_1265</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEPCase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752928.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZN3"/>
    <dbReference type="SMR" id="A1RZN3"/>
    <dbReference type="STRING" id="368408.Tpen_1265"/>
    <dbReference type="EnsemblBacteria" id="ABL78663">
        <property type="protein sequence ID" value="ABL78663"/>
        <property type="gene ID" value="Tpen_1265"/>
    </dbReference>
    <dbReference type="GeneID" id="4600480"/>
    <dbReference type="KEGG" id="tpe:Tpen_1265"/>
    <dbReference type="eggNOG" id="arCOG04435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517433_0_0_2"/>
    <dbReference type="OMA" id="QSAFRYD"/>
    <dbReference type="OrthoDB" id="23334at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01904">
        <property type="entry name" value="PEPcase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007566">
        <property type="entry name" value="PEP_COase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14010">
        <property type="entry name" value="PEPcase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006677">
        <property type="entry name" value="UCP006677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02751">
        <property type="entry name" value="PEPCase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000309617" description="Phosphoenolpyruvate carboxylase">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01904"/>
        </source>
    </evidence>
    <sequence length="464" mass="51243" checksum="174AF466FC739834" modified="2007-02-06" version="1">METPRLMCTQHPDSTVKVPVQEEVEEAVRSFLVYGCDEVMSDYEGKLTPYAQPKEIVVKAGELGVPVGEGFYVTVRAPNPRLEDFDRVDLALEAAVLANYYSYKRLGVQAVRWVVLPMTDSAETVRLVQRLLARKTRVLCEEVGQPCEQAQLVPLLEDVDSLLRVREILRDLHSALAELGSDPGVLRVFLGKSDSALKAGHIASALSLLYALGESAKAGEELGLEVKPILGGGSPPFRGGVNNPRLVGVEVQRYRGYSTVTVQSAVRYDASFSEYQEVRSKLLGGAGGEPGDAGGRVAELARLAASMYRSLASKYLDFVNEYARSVPTTRDRVSWREYGRALELEDKLFSAPRAIVYTAAWYSLGVPPTFLDADFVLEAYRGDFLDEVLGYLPGLEEEWRYDAQFYLPRLAGERLGEELVKKVDEALDAMGLRPEPLEPYEKLARTAPAELRALLLGKVRGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN8</accession>
    <name>A1RZN8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1270"/>
    <dbReference type="EnsemblBacteria" id="ABL78668">
        <property type="protein sequence ID" value="ABL78668"/>
        <property type="gene ID" value="Tpen_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1270"/>
    <dbReference type="eggNOG" id="arCOG02487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04220">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656605_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="418" mass="43371" checksum="C11529AAB828208C" modified="2007-02-06" version="1">MLRRRVYALVLLALAVAYAATRNASAQVPVTVWGYVKMPDGSPAAGASVTVSAGGASASTVTDSTGKYKVDLTVSSTPVTVTVTASLGGYAGSASASGEGVVRVDVVLQPPPPPPKKPTSVYVSVDRPEYGVGDAALVQGRLSPAMQAAVKVVVVAPNGSRYEVSVSTGSDGSFTVRIPLTSRGAWSIYAAFPGSDEYSPSTSQVVTVVAKEKTFLSVSARSPAPGIVQVSGSLAPAPSGAVVEVYVSIDNGSTWARLLNAPVGGDGSFSANLSTAVYGRILVKAVFRGTFDYAQSETAPVAVEVSSPRELLLTQENERLKAREKALNETLERLSAEVGELRRLSDELKSSLSSCNATVEARERALENLERELALLRGELEKTRLLAYAAVPAAAALGALAGFALGRRKRGKREAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ3</accession>
    <name>A1RZQ3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78683">
        <property type="protein sequence ID" value="ABL78683"/>
        <property type="gene ID" value="Tpen_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1285"/>
    <dbReference type="eggNOG" id="arCOG03670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409194_0_0_2"/>
    <dbReference type="OMA" id="STHISYI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="671" mass="73893" checksum="05ADCA2B9D252067" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR4</accession>
    <name>A1RZR4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752959.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1296"/>
    <dbReference type="EnsemblBacteria" id="ABL78694">
        <property type="protein sequence ID" value="ABL78694"/>
        <property type="gene ID" value="Tpen_1296"/>
    </dbReference>
    <dbReference type="GeneID" id="4600650"/>
    <dbReference type="KEGG" id="tpe:Tpen_1296"/>
    <dbReference type="eggNOG" id="arCOG02914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574432_0_0_2"/>
    <dbReference type="OrthoDB" id="136617at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="515" mass="54505" checksum="3689C97A9389DC58" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS2</accession>
    <name>A1RZS2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1304"/>
    <dbReference type="EnsemblBacteria" id="ABL78702">
        <property type="protein sequence ID" value="ABL78702"/>
        <property type="gene ID" value="Tpen_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1304"/>
    <dbReference type="HOGENOM" id="CLU_2476204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="87" mass="9827" checksum="2ADABFADE696AAD0" modified="2007-02-06" version="1">MRVDHPMTLVGLFLSGGDARFEDGKPVLEFRVRSGKVVRVEGARAVELAKVMVDALRAREALELHRFLKALRVDKLDRLEELARSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS3</accession>
    <name>A1RZS3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1305"/>
    <dbReference type="EnsemblBacteria" id="ABL78703">
        <property type="protein sequence ID" value="ABL78703"/>
        <property type="gene ID" value="Tpen_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1305"/>
    <dbReference type="HOGENOM" id="CLU_395689_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="696" mass="74028" checksum="ED36795662ACDB5C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT0</accession>
    <name>A1RZT0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sulfate/molybdate transport systems ATPase component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78710">
        <property type="protein sequence ID" value="ABL78710"/>
        <property type="gene ID" value="Tpen_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1313"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2447827_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="89" mass="9429" checksum="D35D8B1AC7CCB33A" modified="2007-02-06" version="1">MSVKAFPAIGWRASARALATPGILLLDEPSSCIDRESRARLRGEVMKIVRSVNVATLLVSHCVEDSVVADAVVFMRRGGIAAESGTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU2</accession>
    <name>A1RZU2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2014" name="RNA Biol." volume="11" first="1072" last="1082">
            <title>Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.</title>
            <authorList>
                <person name="Hrle A."/>
                <person name="Maier L.K."/>
                <person name="Sharma K."/>
                <person name="Ebert J."/>
                <person name="Basquin C."/>
                <person name="Urlaub H."/>
                <person name="Marchfelder A."/>
                <person name="Conti E."/>
            </authorList>
            <dbReference type="PubMed" id="25483036"/>
            <dbReference type="DOI" id="10.4161/rna.29893"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752987.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="PDB" id="4TXD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A=1-374"/>
    </dbReference>
    <dbReference type="PDBsum" id="4TXD"/>
    <dbReference type="SMR" id="A1RZU2"/>
    <dbReference type="STRING" id="368408.Tpen_1325"/>
    <dbReference type="EnsemblBacteria" id="ABL78722">
        <property type="protein sequence ID" value="ABL78722"/>
        <property type="gene ID" value="Tpen_1325"/>
    </dbReference>
    <dbReference type="GeneID" id="4601564"/>
    <dbReference type="KEGG" id="tpe:Tpen_1325"/>
    <dbReference type="eggNOG" id="arCOG03482">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815400_0_0_2"/>
    <dbReference type="OMA" id="ECPNCMT"/>
    <dbReference type="OrthoDB" id="132588at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017574">
        <property type="entry name" value="CRISPR-assoc_prot_Csc2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18320">
        <property type="entry name" value="Csc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03157">
        <property type="entry name" value="cas_Csc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4TXD"/>
        </source>
    </evidence>
    <sequence length="374" mass="41533" checksum="8831CABA6C1B77F5" modified="2007-02-06" version="1">MSGEKRDVLAELGLGDLRPYLRSIGDKDRIFPKAHRIEVVFLVRAANYLLLRTEGAGTINMTTLEYSGGAMEVPVIQPQKLMAVTRRQMLQLLREYRDSLDEVSKRWLVQEVIGKAKDLGFKKVSEEWNCTIQPPLAEFGEKATDIGMDGFCPHCTIFGAALTEQHNEKFGGLSIGIKTRVRFDPAFATQRRITPETHNKVTEGHLSMTGQALFSEVHVEPGTVFIGRAELVDLTEPELVATLYSLATLRELGGRSGIYGTVRVEILGVKAGKYASTTAYDLAAENAGKGYEEVKKNLKERLEKLGFTPVDNSKLLAAVDHKDPNGLFKDLWRSSIDFAEKMVKWVEELKGGGQKGSGKKSRSKKAEPEESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S037</accession>
    <name>A1S037_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1420"/>
    <dbReference type="EnsemblBacteria" id="ABL78817">
        <property type="protein sequence ID" value="ABL78817"/>
        <property type="gene ID" value="Tpen_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1420"/>
    <dbReference type="HOGENOM" id="CLU_537074_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="524" mass="55094" checksum="9E7239F3326732E8" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S051</accession>
    <name>A1S051_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78831">
        <property type="protein sequence ID" value="ABL78831"/>
        <property type="gene ID" value="Tpen_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1434"/>
    <dbReference type="eggNOG" id="arCOG01192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149754_0_0_2"/>
    <dbReference type="OMA" id="YDPIDEV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="109" mass="11744" checksum="79BCF4BC177D3467" modified="2007-02-06" version="1">MGSAQLAVENYAKAVIAYFRVPSWSHDPSGELLSLLGSIPADAQREAAELADIAKTLAPEHGRATYGEPERGLLPWEVYTRSDAERALELARAASRLTALILSKLGIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S052</accession>
    <name>A1S052_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78832">
        <property type="protein sequence ID" value="ABL78832"/>
        <property type="gene ID" value="Tpen_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1435"/>
    <dbReference type="eggNOG" id="arCOG02218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152747_0_0_2"/>
    <dbReference type="OMA" id="RITLMIR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12973" checksum="B5D12B976AD4C69D" modified="2007-02-06" version="1">MIRTARAEISVARTRSSCLLKVNPYILRSLLLLGKTMGGYVTVSAKVRRELKEEAERLGIRISEVLRRALEEEVKRRKLEELEKRLEAMRGALERIDVERVVRGIREDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S060</accession>
    <name>A1S060_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753105.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1443"/>
    <dbReference type="EnsemblBacteria" id="ABL78840">
        <property type="protein sequence ID" value="ABL78840"/>
        <property type="gene ID" value="Tpen_1443"/>
    </dbReference>
    <dbReference type="GeneID" id="4601152"/>
    <dbReference type="KEGG" id="tpe:Tpen_1443"/>
    <dbReference type="eggNOG" id="arCOG03723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142665_1_0_2"/>
    <dbReference type="OrthoDB" id="128052at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="142" mass="16316" checksum="4CC445AC73EA8E13" modified="2007-02-06" version="1">MSFSEALTKAWKAVELARREVDEYRKDREPLRLRNACEKGWLAVVLATDALLVALGYGKPESYRERRELLGKLEREKPEIARLGLRDRFGARGYYLHVQGYHEGALGADEVAEELEKVERYVGDVERIVESERSAHVERAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1S069</accession>
    <name>A1S069_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753114.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1452"/>
    <dbReference type="EnsemblBacteria" id="ABL78849">
        <property type="protein sequence ID" value="ABL78849"/>
        <property type="gene ID" value="Tpen_1452"/>
    </dbReference>
    <dbReference type="GeneID" id="4601161"/>
    <dbReference type="KEGG" id="tpe:Tpen_1452"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_2"/>
    <dbReference type="OMA" id="WLAYPFM"/>
    <dbReference type="OrthoDB" id="42276at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="300" mass="33642" checksum="01E481EB2AC01CE9" modified="2007-02-06" version="1">MKKESLAALTLILPGMAAFLFFNVYPIFYSVFIAFTNAKLGNFPVQAPTAEPLRIVGLENFVWALSDEKFRTAFLWTWVFVATSVTLKVLTGIFLSVLYNSKYVRGRAIYRSLLIIPWALPLLFTITVWRFMFDPVVGPVNGVLRALGVANPPDWTTDITWGFIALNIIEVWLAYPFMLTVITAALQSVPYTLIEAAIVDGASYWQRLTKVIIPIVSKPIIFATILTSAASFQYFLVPFLFNGSLFEDRFLLLYGYKKAFGSAVPEYGKAAAILVIVTLVLAVYMFVNVKITRIQEGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1S071</accession>
    <name>A1S071_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha amylase, catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753116.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="SMR" id="A1S071"/>
    <dbReference type="STRING" id="368408.Tpen_1454"/>
    <dbReference type="CAZy" id="CBM20">
        <property type="family name" value="Carbohydrate-Binding Module Family 20"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78851">
        <property type="protein sequence ID" value="ABL78851"/>
        <property type="gene ID" value="Tpen_1454"/>
    </dbReference>
    <dbReference type="GeneID" id="4600580"/>
    <dbReference type="KEGG" id="tpe:Tpen_1454"/>
    <dbReference type="eggNOG" id="arCOG02948">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_3_2"/>
    <dbReference type="OMA" id="LDIVCNH"/>
    <dbReference type="OrthoDB" id="5581at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05820">
        <property type="entry name" value="CBM20_novamyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034849">
        <property type="entry name" value="CBM20_novamyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="4">
        <location>
            <begin position="629"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="739" mass="81959" checksum="8F17C191C927D878" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S082</accession>
    <name>A1S082_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753127.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1465"/>
    <dbReference type="EnsemblBacteria" id="ABL78862">
        <property type="protein sequence ID" value="ABL78862"/>
        <property type="gene ID" value="Tpen_1465"/>
    </dbReference>
    <dbReference type="GeneID" id="4601583"/>
    <dbReference type="KEGG" id="tpe:Tpen_1465"/>
    <dbReference type="eggNOG" id="arCOG04226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_2"/>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="OrthoDB" id="101802at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="215" mass="23498" checksum="0CAA8C49B75F5D60" modified="2007-02-06" version="1">MLYGDLRREVADAFRRLEELGLNWGYSGNISVRAGQGVYVVSPSGVLKSKLRPEDVLVVREDGSVVDGRGKPSVEFKTHLAVYRARRDVNAVVHAHPVYSGVLAALRVGLKPVLEELVLYLGGPIEVAEYAPPGTEELARNVVKALGDRCAVLMANHGALACGSTLEEAIANLGYLERAAKVAVYSRILGTPFELPEETVELERRLYLERRFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B6</accession>
    <name>A1S0B6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753161.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1499"/>
    <dbReference type="EnsemblBacteria" id="ABL78896">
        <property type="protein sequence ID" value="ABL78896"/>
        <property type="gene ID" value="Tpen_1499"/>
    </dbReference>
    <dbReference type="GeneID" id="4601408"/>
    <dbReference type="KEGG" id="tpe:Tpen_1499"/>
    <dbReference type="eggNOG" id="arCOG05900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155018_0_0_2"/>
    <dbReference type="OMA" id="PSTVHYH"/>
    <dbReference type="OrthoDB" id="127960at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="14528" checksum="54780A8665313B7A" modified="2007-02-06" version="1">MSGEPELSGTALRIYLELLQSGEMGVRELARELGLPPSTVHYHLNRLEDLGLVKKGEDGYTVAKRIKLKDYVFIGSRAFHRLLLYSAFFLGLSAGEALLTLQGGELNPDRAAAILASLLSGLAFLHEYLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C3</accession>
    <name>A1S0C3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome bd ubiquinol oxidase, subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Tpen_1506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753168.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1506"/>
    <dbReference type="EnsemblBacteria" id="ABL78903">
        <property type="protein sequence ID" value="ABL78903"/>
        <property type="gene ID" value="Tpen_1506"/>
    </dbReference>
    <dbReference type="GeneID" id="4601207"/>
    <dbReference type="KEGG" id="tpe:Tpen_1506"/>
    <dbReference type="eggNOG" id="arCOG02721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_2"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="OrthoDB" id="20297at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL78903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="541" mass="57976" checksum="08DAA859FAEFF7BE" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K6</accession>
    <name>A1S0K6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753251.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1591"/>
    <dbReference type="EnsemblBacteria" id="ABL78986">
        <property type="protein sequence ID" value="ABL78986"/>
        <property type="gene ID" value="Tpen_1591"/>
    </dbReference>
    <dbReference type="GeneID" id="4600555"/>
    <dbReference type="KEGG" id="tpe:Tpen_1591"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OMA" id="RYGVIFN"/>
    <dbReference type="OrthoDB" id="121612at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="119"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="345" mass="38016" checksum="D1430E7A49FAC56B" modified="2007-02-06" version="1">MEPEFEDAYNALVELGLKPYEARVYLAIADGRERTANEIVALTGVPQPRVYETLESLASKGLVEVALSKPKRYRAIEPSRAIEILAGLASRRIESNKERALKALSRVYLQAEDVQAPRVRVIKNKSEAILRARKMLENASYDALVAGPPRLVGEILPHSVGGGAARRLVAVVYYEGVEEPLPAEPWLGLRLRSVGVIPLVIADSARAVILRESYALEIAEEDLIRTFLDFYYHALWRVSSVVKPFEPVEGFEYTATSIWLLNEVLKECLGRGLGAEVTVAGVERRTGRSVTLTGRPAEISENGQGVRVSLVLEVGQRKITVGGLGARLEDVEGRVFRLKVLPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K7</accession>
    <name>A1S0K7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753252.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1592"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78987">
        <property type="protein sequence ID" value="ABL78987"/>
        <property type="gene ID" value="Tpen_1592"/>
    </dbReference>
    <dbReference type="GeneID" id="4600556"/>
    <dbReference type="KEGG" id="tpe:Tpen_1592"/>
    <dbReference type="eggNOG" id="arCOG01407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045353_0_0_2"/>
    <dbReference type="OMA" id="FDPWKDL"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="414" mass="46667" checksum="AE01FA954D7874DE" modified="2007-02-06" version="1">MVTIKATPRYSRRIEDYVPAVGREDIEELVRVAKRLKGVSVVHVNSTAYGGGVAEILHSMVPVMSSLGIDARWEVLEAEDEFFQVTKKIHNGLQGNPSLVLTDEDWRTYLKWNQYNAEILDLDADVVLVHDPQPMALPMFKRGARGVWVWRCHIDISSPNASFWEKLSPFLGYYRGVIVHSEEYVKKEFEDRVLVSPPSIDPLSDKNRELGEKEVESVFKRFGVDPERPVITKVARFDPWKDVFSAVDVFREVKKEVPGAQLLLVSSMARDDPEGAVFYEKVLGYVKGEEGVHILTDAIGVRDLEVNAFQRGTTVGLHTAIREGFGLAVTEMLWKKVPVVARPVGGVKKQVVDGVTGFTAWSVQELAERVKALLADNQLRGRLGEAGREHVRRNFVITQHVKRYLSFFGELLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M7</accession>
    <name>A1S0M7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753272.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1612"/>
    <dbReference type="EnsemblBacteria" id="ABL79007">
        <property type="protein sequence ID" value="ABL79007"/>
        <property type="gene ID" value="Tpen_1612"/>
    </dbReference>
    <dbReference type="GeneID" id="4601904"/>
    <dbReference type="KEGG" id="tpe:Tpen_1612"/>
    <dbReference type="eggNOG" id="arCOG00530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_0_1_2"/>
    <dbReference type="OrthoDB" id="106713at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="181" mass="19451" checksum="CB0AE31EF2436C34" modified="2007-02-06" version="1">MRLKLGEVTLLLGEGVSVGILFGGKSIGVNAGGGYAYLFYTRCGYEPQGIGGDFYSPCGGRVVKPGDALELEGFRVRVVSGYRRAEQGGGVGYVFYLGGVKVYYAGPTGLVEEIVGLRGEDIDVALLPLGEGAMTPEEASEVVRTVRPRVAVPLRAGPERWLYRFRDLSLVYTQVVVPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N1</accession>
    <name>A1S0N1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1616"/>
    <dbReference type="EnsemblBacteria" id="ABL79011">
        <property type="protein sequence ID" value="ABL79011"/>
        <property type="gene ID" value="Tpen_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1616"/>
    <dbReference type="eggNOG" id="arCOG00025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_2"/>
    <dbReference type="OMA" id="HFAQFLA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="250"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="510" mass="57010" checksum="E3832E6635C88C4C" modified="2007-02-06" version="1">MAIVVVDIGTTNIKTGIFNEDGRLLHSFTERVTLEVDASGRAEQNPYEIYSKVVSSLRQAAKFTKGEAEAIFFTSQMHSAMILDREGEPLSGLVTYLDTRPSQFIDEIDAESYELYQETGCPPLYVYPLIKIIYLRRLLNPRAGFKVAVSVKEFPLFKLTGHLAVDVSTASGAQMVDIRSLKWSEKAIEIAGLGEENLPELYIGEKEHLELSSEASTLTGFKKATPIYPGVSDAGAHSFGVIALERNVLALNVGTSAAIRVTEPSPVLDGRHMRFFSYYAGNSRWIVGGAVNNAGVAVEWFLRNFATAEEIVSETANIDRFTLLDIETRLSPPGANGLVFLPYLTGERFPIRDPYFRGAFYGASLSTTRNDMLRAIMEGVAFTLKMILEALKEHGLNPLLTHGGGGGLRIGTWRQIFSDVFGMPLYVVREHVEPTLVGGWIHYSLAQNRIGYREALALKDEILDGGAEPLAQNVEFYSKYFYLYFKFYQALKEYSREFHEFRKSLLKDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S4</accession>
    <name>A1S0S4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="9" type="ordered locus">Tpen_1659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1659"/>
    <dbReference type="EnsemblBacteria" id="ABL79054">
        <property type="protein sequence ID" value="ABL79054"/>
        <property type="gene ID" value="Tpen_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1659"/>
    <dbReference type="eggNOG" id="arCOG01886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_1_1_2"/>
    <dbReference type="OMA" id="YIGFEIS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02009">
        <property type="entry name" value="Tyr_tRNA_synth_type4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023678">
        <property type="entry name" value="Tyr-tRNA-ligase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="388" mass="43578" checksum="6459FAE3BA560E7D" modified="2007-02-06" version="1">MLCSTLSGVSALDPEKVVEAALREPTEELLTPDRLKSLVENGVPLVHYIGFEISGLVHLGTGLISMQKVADLQSVGVKTKVFLADYHSWINRKLGGDLDVIRRVAGGYFKEALRVSLRIVGGDPDKTEFILGSELYEKLGLDYFTNVLRVSMETTLSRVRRSVTILGRSESEALSFAQLLYVPMQVADIFSMGVNIPHGGMDQRKAHVIAIEVGEKLFGYKPVALHHHLLPGLQLDASDWKKLVEAKNSGDKELFRETLVNIKMSKSKPETALFIHDSEEEIRSKIGRAFCPAGEVEMNPLLEIARYIVFRNRKEPFEVVNKKTGERRAFNTYGELEEAFRERLVHPADLKEALSRELAEILAPARKHFTEGPGRSFLEEIKELRITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S7</accession>
    <name>A1S0S7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753322.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1662"/>
    <dbReference type="EnsemblBacteria" id="ABL79057">
        <property type="protein sequence ID" value="ABL79057"/>
        <property type="gene ID" value="Tpen_1662"/>
    </dbReference>
    <dbReference type="GeneID" id="4601244"/>
    <dbReference type="KEGG" id="tpe:Tpen_1662"/>
    <dbReference type="eggNOG" id="arCOG02280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056111_0_0_2"/>
    <dbReference type="OrthoDB" id="137864at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="226" mass="25543" checksum="1462281611C55601" modified="2007-02-06" version="1">MLVEVWRIHQPDCPVVSVSERFPEERLDALSSRLVRGKVYGYLYVGNSPSLRSILDSLRGDERVEEVRVVSKRGSRALLSIRMHSTMAMDALTSEEDVFWHSPLFASNGYEYWVVVVMRGVTKRLREYLEEKGHEVSIVRSMRLNASTFSAAKLVLDAVGIREYLEKRLSNGCTYKDLRLFAGGTLGEVAALTGQARSYLSVRRRRALATCAELVAFLEGIFKDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V5</accession>
    <name>A1S0V5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753350.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1690"/>
    <dbReference type="EnsemblBacteria" id="ABL79085">
        <property type="protein sequence ID" value="ABL79085"/>
        <property type="gene ID" value="Tpen_1690"/>
    </dbReference>
    <dbReference type="GeneID" id="4601013"/>
    <dbReference type="KEGG" id="tpe:Tpen_1690"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_1_2"/>
    <dbReference type="OMA" id="IFTHSIF"/>
    <dbReference type="OrthoDB" id="111480at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="129" mass="14641" checksum="1D60595118912F54" modified="2007-02-06" version="1">MSDEALRWLSEAEWDLETAEILHKAGRYNAAAFYAHQAAEKACKALLYSIHEAPWGHSVRVLLERYFEARGLRIDELLSYARELDRHYIPARYPNAHPAGTPHEAYDSEASSRAISAAKAIVDFARRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W5</accession>
    <name>A1S0W5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753360.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79095">
        <property type="protein sequence ID" value="ABL79095"/>
        <property type="gene ID" value="Tpen_1700"/>
    </dbReference>
    <dbReference type="GeneID" id="4601023"/>
    <dbReference type="KEGG" id="tpe:Tpen_1700"/>
    <dbReference type="eggNOG" id="arCOG03722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115256_4_0_2"/>
    <dbReference type="OMA" id="GWCTKED"/>
    <dbReference type="OrthoDB" id="108958at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="163" mass="18801" checksum="0539E5333C88E735" modified="2007-02-06" version="1">MAVPIALPPSLAKKILEEARKRGVTIEEYIVDFLTRDFDPSDRAREYVEVALYLLDRAREELKRGDVRQAAEKTWGAAALAVKAYAMWKDGRRLTSHGELWDYESLIESELGEWVYDAWMAANGMHTCFYEGWCKESHVETAIKHVEGLVKTVAQRLRELKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X3</accession>
    <name>A1S0X3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/antitoxin, MazE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1708"/>
    <dbReference type="EnsemblBacteria" id="ABL79103">
        <property type="protein sequence ID" value="ABL79103"/>
        <property type="gene ID" value="Tpen_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1708"/>
    <dbReference type="eggNOG" id="arCOG00820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_3_0_2"/>
    <dbReference type="OMA" id="PIRDAVW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="11568" checksum="2250E2E97F148301" modified="2007-02-06" version="1">MCSENLIFLSNKMVSEKIMISEVRVRLSKKNTLYIPKSIAKAVGIREGSKLKLRVEGHRIIIEPVPDPFELALHGSKFAETTFEEFEKESEELQDELFGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X6</accession>
    <name>A1S0X6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753371.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1711"/>
    <dbReference type="EnsemblBacteria" id="ABL79106">
        <property type="protein sequence ID" value="ABL79106"/>
        <property type="gene ID" value="Tpen_1711"/>
    </dbReference>
    <dbReference type="GeneID" id="4601673"/>
    <dbReference type="KEGG" id="tpe:Tpen_1711"/>
    <dbReference type="HOGENOM" id="CLU_2032978_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="121" mass="14070" checksum="F90F1D9510679AB5" modified="2007-02-06" version="1">MARKKSYRASSPLKYEYKMYRLFGGNAPEGLIAQLVATLRSEYEKNYGFYRQAWESLKKQTWVQQLPKGEYGKLKAALNYLLKALRDKKLAPEDTLIELTKVIGLSDDVAQRLIDFVQHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X9</accession>
    <name>A1S0X9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8 and S53, subtilisin, kexin, sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753374.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1714"/>
    <dbReference type="EnsemblBacteria" id="ABL79109">
        <property type="protein sequence ID" value="ABL79109"/>
        <property type="gene ID" value="Tpen_1714"/>
    </dbReference>
    <dbReference type="GeneID" id="4601739"/>
    <dbReference type="KEGG" id="tpe:Tpen_1714"/>
    <dbReference type="eggNOG" id="arCOG00704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265166_0_0_2"/>
    <dbReference type="OMA" id="PWIAFEG"/>
    <dbReference type="OrthoDB" id="363at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="191"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1293" mass="140130" checksum="8D6795C35DB03EDB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S118</accession>
    <name>A1S118_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753413.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1753"/>
    <dbReference type="EnsemblBacteria" id="ABL79148">
        <property type="protein sequence ID" value="ABL79148"/>
        <property type="gene ID" value="Tpen_1753"/>
    </dbReference>
    <dbReference type="GeneID" id="4601951"/>
    <dbReference type="KEGG" id="tpe:Tpen_1753"/>
    <dbReference type="HOGENOM" id="CLU_923238_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="301" mass="32275" checksum="4F85042E0D937C1F" modified="2007-02-06" version="1">MLRMLGYSLIAVSIASLIFVAYATRMGEIPFYLGSVFSGGPSEIVVYGDTALIALEMDVAPPNPVEGFTYRVETSLALFDKAYPGSVLVGQNYVPVILHADYSKPRCAFLDRATHARYRLLVSSPPSPATISNVLKLLERSGAVELQEKNATFPTRVRVIVGGTGFTPKYYAGAVPLKQGGYLVCVVTVKLNSTYVELQNSSTPIRLSLAEAGSKLGLPPDYVEKWLHSIVGHEGSEVVAVYRPTTLQVLRAAVLAAIGALLVVTESRLVGVPPPSPVEAAKALARRLRRILGYARRGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S167</accession>
    <name>A1S167_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753462.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1802"/>
    <dbReference type="EnsemblBacteria" id="ABL79197">
        <property type="protein sequence ID" value="ABL79197"/>
        <property type="gene ID" value="Tpen_1802"/>
    </dbReference>
    <dbReference type="GeneID" id="4601795"/>
    <dbReference type="KEGG" id="tpe:Tpen_1802"/>
    <dbReference type="eggNOG" id="arCOG01064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_5_0_2"/>
    <dbReference type="OMA" id="FPWVYYN"/>
    <dbReference type="OrthoDB" id="25371at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="392" mass="43510" checksum="4F61E5F0D85C6EB6" modified="2007-02-06" version="1">MERVVIIGGGGGGAILANLLPEEFKVTVVDKSEVHFFQPGNLWIAFKGVRKEKFLRPLRSLLKPRVEFVHDEVVSVDLNERVVKTASGKSLSYDYVVFASGAELDYGSVPGHRELLERFGDFYSTPENAEKLHASLRGLKEGRFVIGIADPVYKCPPGPHKAAFLSWEFFARRGLSDKVKVVLAVPVPHAYPSKTIADIIEPELNSRGIELHTFFTVNEVDVANKRIVSLEGEELSFDVAAVVPPHRGPSYAVNPAEVKDGSGYIKIDKYTSRVEGFDDAYAIGDCTNAPTSKSGVTAHLQAEVVAARLQGIDARYSGRTNCPLITDGKGLFVISDYDHPPIPVRLSKFKRLMEDFFVATYWSAVRSPELWSPIFRAYFEATDEFIRRGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S175</accession>
    <name>A1S175_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753470.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1810"/>
    <dbReference type="EnsemblBacteria" id="ABL79205">
        <property type="protein sequence ID" value="ABL79205"/>
        <property type="gene ID" value="Tpen_1810"/>
    </dbReference>
    <dbReference type="GeneID" id="4601803"/>
    <dbReference type="KEGG" id="tpe:Tpen_1810"/>
    <dbReference type="eggNOG" id="arCOG01144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384810_0_0_2"/>
    <dbReference type="OMA" id="IVLIHHP"/>
    <dbReference type="OrthoDB" id="30489at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="147"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="706" mass="77706" checksum="51514BB866EE9568" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1S177</accession>
    <name>A1S177_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753472.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1812"/>
    <dbReference type="EnsemblBacteria" id="ABL79207">
        <property type="protein sequence ID" value="ABL79207"/>
        <property type="gene ID" value="Tpen_1812"/>
    </dbReference>
    <dbReference type="GeneID" id="4602049"/>
    <dbReference type="KEGG" id="tpe:Tpen_1812"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_9_0_2"/>
    <dbReference type="OMA" id="EYCPFYA"/>
    <dbReference type="OrthoDB" id="31834at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL79207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="617" mass="69819" checksum="9F6AC089C2DC94FB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S180</accession>
    <name>A1S180_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal-transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753475.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1815"/>
    <dbReference type="EnsemblBacteria" id="ABL79210">
        <property type="protein sequence ID" value="ABL79210"/>
        <property type="gene ID" value="Tpen_1815"/>
    </dbReference>
    <dbReference type="GeneID" id="4602052"/>
    <dbReference type="KEGG" id="tpe:Tpen_1815"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734919_0_0_2"/>
    <dbReference type="OrthoDB" id="58928at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="375" mass="41438" checksum="4BA33D0E95F66E38" modified="2007-02-06" version="1">MSFTGPPSQGVFTKIDPLGLNDTVSVAAERMWRFELPAVPVVDGEGRYAGIVSIFSLLRTRYQAGTKLGSVLEKAPVVEPSLPLTEVARMLVKTGQPGLAVVEGGRVVGIVSARRLLAGMGLSSRVTARHIAYRLDPLAPSDPLEKARKLIVDLGLRLVPVAEDGKAVGVVRVYDLVNFVYNTPLRRERLGEVKGETSYFLEQPVAKIATANFRTVHVDGYPSVEDIAEGSVVVDSSGKVYGIISPYLLLRRLLPAIEEAKVPLRVEGVDELDFIQRNLIYRKSLDIASEVSRRARLLEMSVVLKSREKSGNRRRYDAIVSIKLDVDSYSARSSGWDAVETVYEALDSAYKVFSKSKEKKREKRISLARLRKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D2</accession>
    <name>A1S1D2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751387.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1867"/>
    <dbReference type="EnsemblBacteria" id="ABL79262">
        <property type="protein sequence ID" value="ABL79262"/>
        <property type="gene ID" value="Tpen_1867"/>
    </dbReference>
    <dbReference type="GeneID" id="4600308"/>
    <dbReference type="KEGG" id="tpe:Tpen_1867"/>
    <dbReference type="HOGENOM" id="CLU_2821120_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="66" mass="7213" checksum="C78D169894D894DD" modified="2007-02-06" version="1">MSWDCGRCEDDTHVRSMEGRVGGGDGAVCYLCGLPAYAYVDGKPVCVYHYAQLISKKKVAAEVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E6</accession>
    <name>A1S1E6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751401.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1881"/>
    <dbReference type="EnsemblBacteria" id="ABL79276">
        <property type="protein sequence ID" value="ABL79276"/>
        <property type="gene ID" value="Tpen_1881"/>
    </dbReference>
    <dbReference type="GeneID" id="4600346"/>
    <dbReference type="KEGG" id="tpe:Tpen_1881"/>
    <dbReference type="HOGENOM" id="CLU_1575030_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="169" mass="19091" checksum="6AA571FD05D4321D" modified="2007-02-06" version="1">MPILVQFERFNSDVKRWIVSYLSPHGWEKLATHKVFVVDPESEEKEEEVEAPIGTTILVSARKVEFYGNARGDDIDKAGYVKVYVDRCGSFPVMAIKDPERRNKDVVLDTPLGSYTCTEVVVNEEEDYVNVADAEYIAVALMARFVALVPSEPFKYKALISTKAKPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E8</accession>
    <name>A1S1E8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1883"/>
    <dbReference type="EnsemblBacteria" id="ABL79278">
        <property type="protein sequence ID" value="ABL79278"/>
        <property type="gene ID" value="Tpen_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1883"/>
    <dbReference type="HOGENOM" id="CLU_1363714_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="200" mass="22886" checksum="16758D0272F8EA11" modified="2007-02-06" version="1">MSFLHHFIGYRGARGLFRLTVKPQNFVDFLRGGFIARASSFKHMSGEKPEEKRPGRGTVEELVWVLGHLINLEEHKWEMGEVEEATAIKEVRRDFVAQLAKELKWACKWKPQWCVLKHLSSLIVHVEEAGTSGDLSPETVEKLQALYKTAWVAIETLLEEWGSLGFAAEETDRLRETVTQALKEKGIDAAKLIREDRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW32</accession>
    <name>A1RW32_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751677.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0002"/>
    <dbReference type="EnsemblBacteria" id="ABL77412">
        <property type="protein sequence ID" value="ABL77412"/>
        <property type="gene ID" value="Tpen_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="4600534"/>
    <dbReference type="KEGG" id="tpe:Tpen_0002"/>
    <dbReference type="eggNOG" id="arCOG01518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_2_2"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="OrthoDB" id="27966at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="365" mass="40282" checksum="B1BAB983ED6F9895" modified="2007-02-06" version="1">MSAYKLDEKSLNVLKEITEIVAPSGFEEPVLERIKQYYSEYADEVRRDNLGSLILVKRGSSERPKVLVAGHVDEVGFLVTGITPEGFITFTTLGGWFEQVLLAQRVVIRTKKGEVYGVITSKPPHLLTPEERQKVVQFSQMYIDVGATSKEEVEKLGVRIGDPVAPWSPFTRTAFEDRIMAKALDDRVGAFIAMEVLKHLRLNGIDHPNTLYAAATVQEEVGLRGAETVGWVADHDVAIVTEVDIAGDVPGIKPSEAPAKLGKGPSIIVYDRSMIPNPRFKEFVIEVAEEAKIPYQLSAVSGGTDAGRLHLYKGGRPSIVIGVPTRHIHSHVSIVSLSDVENAVRLVLELVKRLDQETLKRFVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW36</accession>
    <name>A1RW36_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0006"/>
    <dbReference type="EnsemblBacteria" id="ABL77416">
        <property type="protein sequence ID" value="ABL77416"/>
        <property type="gene ID" value="Tpen_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0006"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="273" mass="29839" checksum="408ECEB7F0239921" modified="2007-02-06" version="1">MRNLNVKYLGSKDWTLRAVDFEANRGELVIIMGPSGCGKTTLFRVLAGLIPSLLPGTVEGQAVVEGIDVVSSGYKGLAGVVGLVYQNPEMQVVTRSVLEELAMGPENLGLPREEIRARIDWVVDMLNLHDFLGRDPQTLSGGEKQLVAIASVLTSKPKVLLLDEPTSMLDHRGTRLVLDAIAELKKEGLTVIVAEHRVEWAAEVADRVVVMGRGTILLEGKPEEVFSRVEDIQRYGVRPPGVAEVAYELRKRGVNVPIPVKMSDSWVLLGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA7</accession>
    <name>A1RWA7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751752.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0077"/>
    <dbReference type="EnsemblBacteria" id="ABL77487">
        <property type="protein sequence ID" value="ABL77487"/>
        <property type="gene ID" value="Tpen_0077"/>
    </dbReference>
    <dbReference type="GeneID" id="4601792"/>
    <dbReference type="KEGG" id="tpe:Tpen_0077"/>
    <dbReference type="HOGENOM" id="CLU_779922_0_0_2"/>
    <dbReference type="OrthoDB" id="91883at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="350" mass="40003" checksum="A5DC0B09D53E7ECA" modified="2007-02-06" version="1">MKVIYVKDPVKAPPSPIAIVEEPEVLKAYLDDDLNPVRCFDEEGFEKPCPEIKVSREDTVFMGGVVSEVLASQYNCSYIDDRVVRLNPSFNPENAKSYLEVAKNPPGSEEIAKDTVLIVVPGSLISRKSMASAVAGLLERGEIRVKAVIDFDAGLNYRVAKIDEWDVLSRYDYWWEVPWNYVVASGRNLRRFVELLTERPVEKPPKKLQVKNYVSLDDFLQSFLEWFGRASSASEKRREVRRFVAFVDENLFEAEGGYRAAVLVKNTRRSVVARWYFTRKFELRAFDGFPPEAVRDVDMEAVLGNVPRESQARIPSHLAAFFVRQAVLSPVRIEDFLAVKAHRWVEVAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA8</accession>
    <name>A1RWA8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751753.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0078"/>
    <dbReference type="EnsemblBacteria" id="ABL77488">
        <property type="protein sequence ID" value="ABL77488"/>
        <property type="gene ID" value="Tpen_0078"/>
    </dbReference>
    <dbReference type="GeneID" id="4602016"/>
    <dbReference type="KEGG" id="tpe:Tpen_0078"/>
    <dbReference type="eggNOG" id="arCOG14756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003332_0_0_2"/>
    <dbReference type="OrthoDB" id="106011at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="277" mass="31489" checksum="FEC57B50794762DB" modified="2007-02-06" version="1">MSYPEVYHDISILLLPEALSELKKASAPQLEEISPVEKYLPQLLTAATERLKSRGLGVEEKEFQEVFRYGITSIARAYAEGDWRFYAFFSELFTKISIIDSLYEWSINIASLPPRATFFEVNTVAPVYLSRLSQRVSGSPGIITEKRFLYNSTFKEIYDEYSRRYDLKLNVVPLEDADRLASLNGTVDVLVFATLDAMSLGWRTILGMASSLLKKGGTLIAIVPDNKREGLRSLLRAWRIPDYEPPETLATNLQDSRFTKIRYSTKGPFSAFVAQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG9</accession>
    <name>A1RWG9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751814.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0139"/>
    <dbReference type="EnsemblBacteria" id="ABL77549">
        <property type="protein sequence ID" value="ABL77549"/>
        <property type="gene ID" value="Tpen_0139"/>
    </dbReference>
    <dbReference type="GeneID" id="4602182"/>
    <dbReference type="KEGG" id="tpe:Tpen_0139"/>
    <dbReference type="eggNOG" id="arCOG04409">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121772_0_0_2"/>
    <dbReference type="OMA" id="VYPYATR"/>
    <dbReference type="OrthoDB" id="112391at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="192" mass="21014" checksum="7F407A066EA17257" modified="2007-02-06" version="1">MDVYLGVDLSASRRRKSAYALLYEDLSCKAGFFSGDDELVALAEEYSPRVVGIDAPLSFPKGGRLRGCDKALLRLGVKVFSPVFSGMLELTSRGIKLKEALEERGFEVIEVYPGGSQDLLGIPRKSRNKKGLLEGLRSLGVKFEETLQGDILDAITAAFTSYAYAVGEYILVSSEDCRLILPSPTLRPSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH0</accession>
    <name>A1RWH0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dCTP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751815.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0140"/>
    <dbReference type="EnsemblBacteria" id="ABL77550">
        <property type="protein sequence ID" value="ABL77550"/>
        <property type="gene ID" value="Tpen_0140"/>
    </dbReference>
    <dbReference type="GeneID" id="4602183"/>
    <dbReference type="KEGG" id="tpe:Tpen_0140"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_3_0_2"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="OrthoDB" id="91282at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19339" checksum="30BDB621817B2A8B" modified="2007-02-06" version="1">MLSGAEIRRLINEGKLVIEPFSDEIVRENGVDLRIGEEVAVLLNNPEPLDPERLREVDLSQYYRVFKTDSFVLQPYMKVLVTTLEYIKMPVDVAAIIGVRSTFARLGVSIPPTLIDAGFEGQITIEIHGGAFPIVLRKGQRFAHVAFYRLEGEPVPYKGKYQRQRGVTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH1</accession>
    <name>A1RWH1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751816.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0141"/>
    <dbReference type="EnsemblBacteria" id="ABL77551">
        <property type="protein sequence ID" value="ABL77551"/>
        <property type="gene ID" value="Tpen_0141"/>
    </dbReference>
    <dbReference type="GeneID" id="4602184"/>
    <dbReference type="KEGG" id="tpe:Tpen_0141"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="58645at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="52"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="236" mass="26282" checksum="91704DA36EF7E6BE" modified="2007-02-06" version="1">MNSCLHEPRGYELGDEILARLKGAFSLGRGEFVALDVARRGDFFGVLVATIISQNTNENNTLKAFASLEERVGVECEKIRKAGLSELAEAIRPAGLQEQKAKAIKQVASLLYEKYGCDIGKLLSRGVEEVIRELKQIEGIGDKTIDVLLANYGYPVLPIDTHVRRVSVRLGLARPGSYRAMQKSLHGFFREEARLDAHLYLIKLGRTLCRAKNPLCDECPLSDLCCYYRTSRAPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM2</accession>
    <name>A1RWM2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0192"/>
    <dbReference type="EnsemblBacteria" id="ABL77602">
        <property type="protein sequence ID" value="ABL77602"/>
        <property type="gene ID" value="Tpen_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0192"/>
    <dbReference type="eggNOG" id="arCOG00223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515476_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="528" mass="57719" checksum="35EC4C303A88D343" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN8</accession>
    <name>A1RWN8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-alanine dehydrogenase</fullName>
            <ecNumber evidence="1">1.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751883.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0208"/>
    <dbReference type="EnsemblBacteria" id="ABL77618">
        <property type="protein sequence ID" value="ABL77618"/>
        <property type="gene ID" value="Tpen_0208"/>
    </dbReference>
    <dbReference type="GeneID" id="4602219"/>
    <dbReference type="KEGG" id="tpe:Tpen_0208"/>
    <dbReference type="eggNOG" id="arCOG01035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_3_2_2"/>
    <dbReference type="OMA" id="HKNEIAP"/>
    <dbReference type="OrthoDB" id="96993at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="345" mass="37782" checksum="FE32FD221F841BD7" modified="2007-02-06" version="1">MHVKVLRAEDVAHVIREVGLNTFLDGLINRLEEVFRRWRELKVVPRVSFHYASGVMEAMPASDARWYSVKIVNGHPGNPLRGLQTVVAVGVLADVETGYPVMIADATLLTALRTGATSALATKYLARRGSENLGIIGTGAQSEFLVYSISRVANSVEKVFFYDIDPKAMEKFEKNISRLGFELVRAGSPREVALNSDVLVTATTSKGKDRVVLNEWVRPGTHINAVGGDAPGKTELDPAILLRSKLVVELLEQAIVEGETQSVGRDAVYAELWEVVSGLKHGRSSEEEVTVFDSVGIAVEDLATLTYLYGLAERMQVGLDLELFPRLSDPKDLFFTLISDAGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP0</accession>
    <name>A1RWP0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751885.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="SMR" id="A1RWP0"/>
    <dbReference type="STRING" id="368408.Tpen_0210"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77620">
        <property type="protein sequence ID" value="ABL77620"/>
        <property type="gene ID" value="Tpen_0210"/>
    </dbReference>
    <dbReference type="GeneID" id="4602221"/>
    <dbReference type="KEGG" id="tpe:Tpen_0210"/>
    <dbReference type="eggNOG" id="arCOG03284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452458_0_0_2"/>
    <dbReference type="OrthoDB" id="33000at2157"/>
    <dbReference type="BRENDA" id="3.2.1.41">
        <property type="organism ID" value="11662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="194"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="609" mass="68955" checksum="A2F9532F5C7AA43C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ8</accession>
    <name>A1RWQ8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="8" type="ordered locus">Tpen_0228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751903.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0228"/>
    <dbReference type="EnsemblBacteria" id="ABL77638">
        <property type="protein sequence ID" value="ABL77638"/>
        <property type="gene ID" value="Tpen_0228"/>
    </dbReference>
    <dbReference type="GeneID" id="4601218"/>
    <dbReference type="KEGG" id="tpe:Tpen_0228"/>
    <dbReference type="eggNOG" id="arCOG04072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_4_2_2"/>
    <dbReference type="OMA" id="MDPYKVI"/>
    <dbReference type="OrthoDB" id="113971at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="10109" checksum="F86D5A12FD35A9B6" modified="2007-02-06" version="1">MSSGVDYTKIIVKPYLTEKTLRLMEETNTLVFIVDRRASKPEIKRAVEALYNVKVAKVNTLITPEGFKKAYVKLSKEYSAADVASRIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR2</accession>
    <name>A1RWR2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751907.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0232"/>
    <dbReference type="EnsemblBacteria" id="ABL77642">
        <property type="protein sequence ID" value="ABL77642"/>
        <property type="gene ID" value="Tpen_0232"/>
    </dbReference>
    <dbReference type="GeneID" id="4600702"/>
    <dbReference type="KEGG" id="tpe:Tpen_0232"/>
    <dbReference type="eggNOG" id="arCOG00741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183485_0_0_2"/>
    <dbReference type="OMA" id="KIAYWRL"/>
    <dbReference type="OrthoDB" id="128706at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006793">
        <property type="entry name" value="FaeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04703">
        <property type="entry name" value="FaeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="73" mass="8899" checksum="FD57EA11C3C2B98A" modified="2007-02-06" version="1">MPRKVTDKILERKKLIYEYLKKHGPMPTVELVRDLKLSHSQVFYILRLLLREKKVKEERRGKMAYWIALESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS2</accession>
    <name>A1RWS2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="8" type="ordered locus">Tpen_0242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751917.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0242"/>
    <dbReference type="EnsemblBacteria" id="ABL77652">
        <property type="protein sequence ID" value="ABL77652"/>
        <property type="gene ID" value="Tpen_0242"/>
    </dbReference>
    <dbReference type="GeneID" id="4601469"/>
    <dbReference type="KEGG" id="tpe:Tpen_0242"/>
    <dbReference type="eggNOG" id="arCOG04092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="97230at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="69"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="182" mass="20385" checksum="33B3346892BD9E10" modified="2007-02-06" version="1">MAKVGPVLETDHPMRRVFIGKVVVNIGVGEGGERLMKAAKLLEELTGQKPSLRPAKKTVREFGVKKGENIGVMVTLRGEKAINFLKKALAAVDYKIHEKSIDRHGNVAFGVKEHILIPGVKYDPEVGIFGFDVIIAMERPGYRVARRRRKKSKVPARHRVTKEETITFLEKILGVQVIRGKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS4</accession>
    <name>RL24_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl24</name>
        <name type="ordered locus">Tpen_0244</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751919.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWS4"/>
    <dbReference type="SMR" id="A1RWS4"/>
    <dbReference type="STRING" id="368408.Tpen_0244"/>
    <dbReference type="EnsemblBacteria" id="ABL77654">
        <property type="protein sequence ID" value="ABL77654"/>
        <property type="gene ID" value="Tpen_0244"/>
    </dbReference>
    <dbReference type="GeneID" id="4601471"/>
    <dbReference type="KEGG" id="tpe:Tpen_0244"/>
    <dbReference type="eggNOG" id="arCOG04094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_2_1_2"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="107015at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000355740" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="131" mass="14561" checksum="7EBC71CB970D63C1" modified="2007-02-06" version="1">MVKGTSSKPGKVRKREVYDAPLHIRSKKIVAPLSAELQQKLGIKRIRVRKGDRVLIVRGSFKGHEGKVTSVDVKKGRIHVEGATLRKADGTEVPFPIHPSKVVVTELDLSDPRRKELVERKKQVVVSGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV2</accession>
    <name>A1RWV2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fni</name>
        <name evidence="9" type="ordered locus">Tpen_0272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751947.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0272"/>
    <dbReference type="EnsemblBacteria" id="ABL77682">
        <property type="protein sequence ID" value="ABL77682"/>
        <property type="gene ID" value="Tpen_0272"/>
    </dbReference>
    <dbReference type="GeneID" id="4601893"/>
    <dbReference type="KEGG" id="tpe:Tpen_0272"/>
    <dbReference type="eggNOG" id="arCOG00613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_2"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="OrthoDB" id="42330at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="179"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="361" mass="38501" checksum="4E54DB123F5A8BE7" modified="2007-02-06" version="1">MSSDIIFTRKDQHLVYSLKENVQARGVTTLLECVRFVHQTVLEANFSDVDVSTKFLGYEVAAPIVISGMTGGTPMGGKVNAMLAEVAQRLKVPIGVGSQRAALKDRAAVETFRVVREKAPDVPVIANIGASQVSMGLSAGEVQELLDMVGADALAVHLNPLQEVLQPEGEPSFKNFLGNLREIVKSVKVPVILKQTGEGFSRESALKIADTGVKGVDVGGAGGTSFAVIEGLRARYAGLDLHEEIAFEFAGWGIPTAASVLEVRSALPDILLIATGGIRSGLDAAKVIRLGADFAGLALPVLKEVYYRGVEGGYRFLEKVIRELKIAVFLTGGRTLADLKNAPIVITGELKDWVVQRGLRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV4</accession>
    <name>RS2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps2</name>
        <name type="ordered locus">Tpen_0274</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751949.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWV4"/>
    <dbReference type="SMR" id="A1RWV4"/>
    <dbReference type="STRING" id="368408.Tpen_0274"/>
    <dbReference type="EnsemblBacteria" id="ABL77684">
        <property type="protein sequence ID" value="ABL77684"/>
        <property type="gene ID" value="Tpen_0274"/>
    </dbReference>
    <dbReference type="GeneID" id="4601895"/>
    <dbReference type="KEGG" id="tpe:Tpen_0274"/>
    <dbReference type="eggNOG" id="arCOG04245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_3_0_2"/>
    <dbReference type="OMA" id="QQKTKDM"/>
    <dbReference type="OrthoDB" id="63341at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000352081" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <sequence length="214" mass="23738" checksum="BB2605BC74987035" modified="2007-02-06" version="1">MSLDELKLLEGQLLIPLEMYLAAGIRIGTKMKSKFMEPFIYSARPDGLYLLDVKKTDERIRIAAKMIARYDPSKFVVVSGRQYGHRPVRKFCGLVGCKPMLGRVLPGTFTNPALSHFTEADLMMVTDPRVDEQAVVEAGTMGIPVIALCDTDSPISNVDLIIPTNNRGRKALALIFWLLAREVLRIRGDIPPNGELPVPLSDFEARILTTGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW3</accession>
    <name>A1RWW3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L30e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl30e</name>
        <name evidence="5" type="ordered locus">Tpen_0283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751958.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0283"/>
    <dbReference type="EnsemblBacteria" id="ABL77693">
        <property type="protein sequence ID" value="ABL77693"/>
        <property type="gene ID" value="Tpen_0283"/>
    </dbReference>
    <dbReference type="GeneID" id="4602093"/>
    <dbReference type="KEGG" id="tpe:Tpen_0283"/>
    <dbReference type="eggNOG" id="arCOG01752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_1_0_2"/>
    <dbReference type="OMA" id="RPHKIMA"/>
    <dbReference type="OrthoDB" id="117214at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_L30e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="4">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="104" mass="11051" checksum="E2B3A4AF76002993" modified="2007-02-06" version="1">MGAEFIRELQTAIKTGKVVLGSRKTIKLLSTGKAKMVILAQNAPTIIAEEIKYKARLAGIPVYVFEGTSKDLGAACNKPFFVSAIAVLDPGESNLIEMAKGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX4</accession>
    <name>A1RWX4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S18P alanine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0294"/>
    <dbReference type="EnsemblBacteria" id="ABL77704">
        <property type="protein sequence ID" value="ABL77704"/>
        <property type="gene ID" value="Tpen_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0294"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OMA" id="SGEIMGY"/>
    <dbReference type="OrthoDB" id="95090at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:peptide alpha-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="PTHR23091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="150" mass="17598" checksum="FFABC96DBB2764D9" modified="2007-02-06" version="1">MREEELGDVMRINKKVLPENYPAFYFELHYRNFGKAFLVAEVKGKIVGYIMCRVEYDNLYTNPQKVGRRGHVISLAVLEEWRRKGIGYNLMVKAMEAMKTYYGAEEYYLEVRVSNEPAIRLYKKLGFNVVKILQGYYLDGEDAYLMARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX17</accession>
    <name>A1RX17_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H+-transporting two-sector ATPase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0338"/>
    <dbReference type="EnsemblBacteria" id="ABL77747">
        <property type="protein sequence ID" value="ABL77747"/>
        <property type="gene ID" value="Tpen_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0338"/>
    <dbReference type="eggNOG" id="arCOG02455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_3_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="12080" checksum="203D7A357928E241" modified="2007-02-06" version="1">MRQKRLAYMLLAVNVAIVVLATTVMASAISRATAYNVQGQEAAKKLELPDAIALLAGAIAVVGSTIASGIALRSVATAGFAAVAEKPELTTWMLIMGGLAEGIAVYGLLLAILILGKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX20</accession>
    <name>VATB_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpB</name>
        <name type="ordered locus">Tpen_0341</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABL77750" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77750.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052885375.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX20"/>
    <dbReference type="SMR" id="A1RX20"/>
    <dbReference type="STRING" id="368408.Tpen_0341"/>
    <dbReference type="EnsemblBacteria" id="ABL77750">
        <property type="protein sequence ID" value="ABL77750"/>
        <property type="gene ID" value="Tpen_0341"/>
    </dbReference>
    <dbReference type="GeneID" id="4601451"/>
    <dbReference type="KEGG" id="tpe:Tpen_0341"/>
    <dbReference type="eggNOG" id="arCOG00865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="OrthoDB" id="8899at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000322508" description="V-type ATP synthase beta chain">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="460" mass="51612" checksum="D379736D626E3BFB" modified="2008-02-26" version="2">MYPGKVYRGVKEIRGSLLIVDGIEEAAYDEVVKIYGKDSRERFGRVLETSIGQAVVQVLGDREGLETDTLLKFTGSTFKIRVSEDVIGRVFNGRFEPIDGLPPILSGELREITGEPINPISREYPHDFIQTGVSAIDGLFSMVRGQKLPIFSVSGLPHNLLAAQVARQATVRGEGEQFAVVFAGIGLRKTEAEFFLEQFRETGAIERLVAVLNMADDPAVERLMTPRIALTVAEYLAFDLDMHVLVIMSDMTNYCEALREVSSARGEIPGRLGYPGYMYSDLATIYERAGVIKGKKGSITLFPILTMPGGDLRHPIPDLTGYITEGQIFLSQEMYAQGIYPPINILPSLSRLMKSGIGPGKTREDHRYLADQLYDAYSRGVKARDLARIIGEIGLSERNRRFLKFAEEFENKFVNQGFYENRSIEETLDLGWQVLSILPEEELVRIPQKIIEKYHPKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX23</accession>
    <name>A1RX23_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0344"/>
    <dbReference type="EnsemblBacteria" id="ABL77753">
        <property type="protein sequence ID" value="ABL77753"/>
        <property type="gene ID" value="Tpen_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0344"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259163_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="184" mass="20306" checksum="1EC04766E01A8862" modified="2007-02-06" version="1">MARTPRTGEKAEWERLRERARVLAFAVPAAGLIAFLVAFFVGGNSWGILALGVEVATIGVGLYFTFEALVRAYTLRLYHGLREGVKPPQPQEARQPPVATVPPPKPLLTTTPQPQPQLVRRPTETTAPQRGEPLLTRPPVRAIELPPPSPVEENAETKRCPYCGRELPYGDLHIICPFCGRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX32</accession>
    <name>A1RX32_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752027.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0353"/>
    <dbReference type="EnsemblBacteria" id="ABL77762">
        <property type="protein sequence ID" value="ABL77762"/>
        <property type="gene ID" value="Tpen_0353"/>
    </dbReference>
    <dbReference type="GeneID" id="4600891"/>
    <dbReference type="KEGG" id="tpe:Tpen_0353"/>
    <dbReference type="eggNOG" id="arCOG04130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076814_1_0_2"/>
    <dbReference type="OMA" id="ANENKYV"/>
    <dbReference type="OrthoDB" id="112466at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="209" mass="24431" checksum="D89731217BBECF13" modified="2007-02-06" version="1">MFRGDYQRKPYRPLDENLVVLDMLPYGDAVRGIKYPLVQTIGEYRFLLVELKSTTPQAPSLKPLDRISSEYLREARLLSFARYLTYDELSATAKANLVEAVTAIVKVQEKRFVDFFNNAQPLSKKAHTLELLKGIGKRTLWKILDERRRKPFESFEDIKARADIDPVELIVERILEELKEPQTIYIFVNPPYGPVARSGRREGFREYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX42</accession>
    <name>A1RX42_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0363"/>
    <dbReference type="EnsemblBacteria" id="ABL77772">
        <property type="protein sequence ID" value="ABL77772"/>
        <property type="gene ID" value="Tpen_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0363"/>
    <dbReference type="eggNOG" id="arCOG05836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163113_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038133">
        <property type="entry name" value="Ribo_III_sf_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021568">
        <property type="entry name" value="Ribonuclease_III_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11469">
        <property type="entry name" value="Ribonucleas_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="124" mass="13504" checksum="A12B293C32D9D4C1" modified="2007-02-06" version="1">MGRMLKEELEKVLRSKELARLGDSLVNFLVSAALTLIGRPTGVKVPGETLARAFLSSRLSKLGKPRGIAPGEAMEAFLAYAWLKGSLSCEESVEMLYTGLREGYDVAQALAKLADYLLEKIEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX45</accession>
    <name>A1RX45_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752040.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0366"/>
    <dbReference type="EnsemblBacteria" id="ABL77775">
        <property type="protein sequence ID" value="ABL77775"/>
        <property type="gene ID" value="Tpen_0366"/>
    </dbReference>
    <dbReference type="GeneID" id="4601495"/>
    <dbReference type="KEGG" id="tpe:Tpen_0366"/>
    <dbReference type="eggNOG" id="arCOG01118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143279_0_0_2"/>
    <dbReference type="OMA" id="MRVYTVY"/>
    <dbReference type="OrthoDB" id="106682at2157"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="154" mass="17596" checksum="7396095D5ED4A04D" modified="2007-02-06" version="1">MSHEGLTEKQVELIRHLFRRSKPLRVFTVTDTQQKISLELGISRQALNIHLKKLKEAGYIRTGRGFLDLTEKVLPIVGKQAGDTFIFVKLHPTKRLQAYEIIKTLPVDRVYRVTGDIDLIIQASQAMLDEILDKINSIEGVKETKTYVIIEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX89</accession>
    <name>A1RX89_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaD</name>
        <name evidence="4" type="ordered locus">Tpen_0410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0410"/>
    <dbReference type="EnsemblBacteria" id="ABL77819">
        <property type="protein sequence ID" value="ABL77819"/>
        <property type="gene ID" value="Tpen_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0410"/>
    <dbReference type="eggNOG" id="arCOG01223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_5_0_2"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="168" mass="18718" checksum="81CDBF60D73A4C8B" modified="2007-02-06" version="1">MTEILSADGTQKECLCTRGVVGGTFSLLHRGHRRLLRFALLCSQELLVGVTSDEYVKERGKSHPVEPYEVRALSVLTFLKTVDPSRPVAIVPIDDEYGPATSDPCADCIFVSEETFPGAVKVNMLRRLRGLPPLKIFAVELVTVEGVRLSSTYLWERLQRKRGSARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX97</accession>
    <name>A1RX97_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752092.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0418"/>
    <dbReference type="EnsemblBacteria" id="ABL77827">
        <property type="protein sequence ID" value="ABL77827"/>
        <property type="gene ID" value="Tpen_0418"/>
    </dbReference>
    <dbReference type="GeneID" id="4600496"/>
    <dbReference type="KEGG" id="tpe:Tpen_0418"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="OrthoDB" id="144493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="474" mass="54334" checksum="1E01CB8884194D9F" modified="2007-02-06" version="1">MGCEERLEEEVREETWRRAALSLYSTEVEDRRRSRGGKKGRVHYRGLYDAVSRINWDFTRFAAHALSVVPDEAYSRFGRLFDIDARKYLLLNDDEKPREGGAVVELRDRLQAIVDATEDGLKVERHGKHWQVYIPGENWHVIAYKPTHNWIILIPLKGFWVESEFPRVLVNTPISVLQSLQKGWVLTDVTPPHGRYSYVQFSTTQPWQLPATLAAFPSDNICLGVTAGALGSTKLSIEWKVHVYSYEEELGWASELIGEVKRAEFRQLIDACRVLQGDPVALHTAFLGDGYLAFFLRLRMLFFSIGHEIFYLPAESAIVNARLAVELAPEYTKFVSLVTKCPKIKHFLFVGFGLPQKRGMRDGQRKTPFYAEIAGARLHLVYISTRNHVYARIAVDDAPQGWVEEARAQGWDVRVVNMGSEEYYQVTHVSLMEHARYDEALRETLLAFAKAKAEQYPKAWELVERLEKLGTGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB7</accession>
    <name>A1RXB7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752112.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0438"/>
    <dbReference type="EnsemblBacteria" id="ABL77847">
        <property type="protein sequence ID" value="ABL77847"/>
        <property type="gene ID" value="Tpen_0438"/>
    </dbReference>
    <dbReference type="GeneID" id="4602175"/>
    <dbReference type="KEGG" id="tpe:Tpen_0438"/>
    <dbReference type="eggNOG" id="arCOG01048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735402_0_0_2"/>
    <dbReference type="OMA" id="AGVISEM"/>
    <dbReference type="OrthoDB" id="43015at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="370" mass="42615" checksum="8CED7369BC52FEA7" modified="2007-02-06" version="1">MSQADLVAFVTGISGSGRLSVLQEVSSEAPELKVIDVGTRMYDKSRELGVVIPDGKILDMDPLALEYLRATTFEDILRDVEELRRQKQVVAISTHVSFRWKKHLLHAFNFYYVNRIAPDLYVNVLDNAHLVYAALQSSSAWRGKLSLKEVLIWRDEEAFITRLLAEYQRKPFYIFPRREDPLMLKKVLFDVERAKKEGRRPAPKAYLSYPITHVKGDPDFLEEKNEVKKRLKEAGIVVFDPISVEDSPLIDMAYEAEKAGKKEVEFEMDGRTFSLPVSQIYDAIEDIRDQIVVRDYQLINQSDIIVVFYPTTVLSPGVLSEIKYGYTHNKHVFAIFPHQSASPFFEYYTTRIFKDVDSLLDHLREVGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB9</accession>
    <name>A1RXB9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752114.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0440"/>
    <dbReference type="EnsemblBacteria" id="ABL77849">
        <property type="protein sequence ID" value="ABL77849"/>
        <property type="gene ID" value="Tpen_0440"/>
    </dbReference>
    <dbReference type="GeneID" id="4601863"/>
    <dbReference type="KEGG" id="tpe:Tpen_0440"/>
    <dbReference type="HOGENOM" id="CLU_955183_0_0_2"/>
    <dbReference type="OrthoDB" id="136906at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="291" mass="31316" checksum="6F70E1D57FBC59D3" modified="2007-02-06" version="1">MATVGILESLYEALSARASVIAEFTDWLGFPVKVFELGDKDKPPVVLIGGLEWECLASSETLLEGVLRYEGDVHVIVIPCVNPSFALGLEPVMQRLLGTTNTAGFELLKVLAEEGKLISSLESAKVYAYGNLLVVAVENALSMKDLEGILLGVKEYVQEDYPVLVVGREGISLVSYAEGQLSPAFLSPHLREVLEWIKSLDPLLVVLLRCCDKEKSIRLPSSASPSLETLAGIAGQHLGGSLAVTRGETLAEKIGLVDAPVAEICLSKAEEKRDDVIYAVHAILGSAYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC4</accession>
    <name>A1RXC4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752119.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0445"/>
    <dbReference type="EnsemblBacteria" id="ABL77854">
        <property type="protein sequence ID" value="ABL77854"/>
        <property type="gene ID" value="Tpen_0445"/>
    </dbReference>
    <dbReference type="GeneID" id="4601868"/>
    <dbReference type="KEGG" id="tpe:Tpen_0445"/>
    <dbReference type="eggNOG" id="arCOG01808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030780_0_0_2"/>
    <dbReference type="OMA" id="SAQILYM"/>
    <dbReference type="OrthoDB" id="8417at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="126"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="400"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="604" mass="65922" checksum="1E78BDC0BF793D5C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC5</accession>
    <name>A1RXC5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0446"/>
    <dbReference type="EnsemblBacteria" id="ABL77855">
        <property type="protein sequence ID" value="ABL77855"/>
        <property type="gene ID" value="Tpen_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0446"/>
    <dbReference type="eggNOG" id="arCOG00541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="YLKAMLG"/>
    <dbReference type="OrthoDB" id="39954at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="235"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="428" mass="46860" checksum="C44731F02A61E016" modified="2007-02-06" version="1">MSYIMADVYLKALGAAREVGRSAILLGVEGKLILLDYGVSIEGEEPQFPLPVPPKGIHAVAISHAHLDHSGAAPLLYVSGQPPLISTPLTATLSDLLIKDFMKLSKYYIPYEAPEVEKMLESLVPLGYGESYDIGSVTIRVLDAGHIPGSAMIQIETPSLNVLYTGDYSLHDTCLLRGAGISEFSKADVVIMESTYAEYDHPPREEVEREFVKTVLEVVEDGGIAFIPAFAVGRAQEILCVLAKYDLQVPIYVDGMARTANDLIAEDSHLLREPSLFKKAVEMSTKVKDWDHRKKILSKPGVIISPAGMLQGGPSEYYMEKIMENEKNAVIFVSYVIPETPARQVIETGIYASPTKRGPVKARIEWFDFSAHCGHSELVKTLDSAKKGSKVVLVHGEEEAAVKLAELSVKAGHETFVPRLGEELNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC6</accession>
    <name>A1RXC6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0447"/>
    <dbReference type="EnsemblBacteria" id="ABL77856">
        <property type="protein sequence ID" value="ABL77856"/>
        <property type="gene ID" value="Tpen_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0447"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="OMA" id="YYGFEIT"/>
    <dbReference type="OrthoDB" id="100198at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="79"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19971" checksum="43D00D9B3F070CD6" modified="2007-02-06" version="1">MSYEFDEWFKRIRKMMEEFDKMFEEMMREPMLYSGEKGRRIIGPYYYGFSVEIGPDGVPKVREWGNIRPGPIKPVVKESIEPFTDVFDEGDHYRVILDIPGVEKDEINVEATENSLVVSTTGERKYYKEVRFSDPVDPSTAKAQYKNGVLTVTIEKKEKPKKERGVKIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC9</accession>
    <name>A1RXC9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77859">
        <property type="protein sequence ID" value="ABL77859"/>
        <property type="gene ID" value="Tpen_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0450"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575730_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="465" mass="54241" checksum="D80339BF064D575A" modified="2007-02-06" version="1">MGRGIELEVDEKTREIVERVARERVEKASSRLDERYLEVYEYLARVARKLRERWPWLSILTIYMLILLDKAYEQAKQRLNEFLSAEWHVFRSGKKTWRIYPKDKGFYVMIGKAPKGNFNVVLPLDNVATDVFIKGLKLTARVRWYALRGWLLSDIHYSRKRRLLDAGTDQSWQVIAISALLNDVVARIAVRSLILGKNSLNFAWRILTNILLPWELKGKAKEITTEKFVLRIKKKDVNKLKPSEALTLLTLYLGDGAIPNFKVNMLHILANNRDLPITGAKAIQLAQKMLEVSGEYGELLKLLQVRKYQYLEILSNRKANNVVRMHIVVAGVKMHLILVGGASHFGLEARVLETRKTKIPENFAELAEREGLKVEETTIRYKGWNGRVYEYRAWHAYTEELLEFAHLRPQAYCVYLKYLYAKREKYENRCTIEKVQRLIDRIIRDARKHAPKTLEACLEELGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD6</accession>
    <name>A1RXD6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752131.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0457"/>
    <dbReference type="EnsemblBacteria" id="ABL77866">
        <property type="protein sequence ID" value="ABL77866"/>
        <property type="gene ID" value="Tpen_0457"/>
    </dbReference>
    <dbReference type="GeneID" id="4601860"/>
    <dbReference type="KEGG" id="tpe:Tpen_0457"/>
    <dbReference type="eggNOG" id="arCOG01355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_2"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="OrthoDB" id="5945at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="217"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="519" mass="58614" checksum="58124278A0B86994" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF6</accession>
    <name>A1RXF6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752151.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0477"/>
    <dbReference type="EnsemblBacteria" id="ABL77886">
        <property type="protein sequence ID" value="ABL77886"/>
        <property type="gene ID" value="Tpen_0477"/>
    </dbReference>
    <dbReference type="GeneID" id="4602036"/>
    <dbReference type="KEGG" id="tpe:Tpen_0477"/>
    <dbReference type="HOGENOM" id="CLU_2565929_0_0_2"/>
    <dbReference type="OrthoDB" id="131960at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="9234" checksum="67BDB453AEE4ACD3" modified="2007-02-06" version="1">MSDRKRFTSRAVLGVLTVVLAVVFAYYSYKTLAYILNWEKPPGDPLAAYTTYVQVMIYSIFILTSVFLLHETFSSTRGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI4</accession>
    <name>A1RXI4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752179.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77914">
        <property type="protein sequence ID" value="ABL77914"/>
        <property type="gene ID" value="Tpen_0507"/>
    </dbReference>
    <dbReference type="GeneID" id="4601003"/>
    <dbReference type="KEGG" id="tpe:Tpen_0507"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="7529" checksum="141BA00981DF6A97" modified="2007-02-06" version="1">MQTIGALSRLLASTLKGDGLYKARLVEALDAIEEFLASVGSAPARVEEDEELARELEEEAEELRKLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI7</accession>
    <name>A1RXI7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752182.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0511"/>
    <dbReference type="EnsemblBacteria" id="ABL77917">
        <property type="protein sequence ID" value="ABL77917"/>
        <property type="gene ID" value="Tpen_0511"/>
    </dbReference>
    <dbReference type="GeneID" id="4601008"/>
    <dbReference type="KEGG" id="tpe:Tpen_0511"/>
    <dbReference type="eggNOG" id="arCOG00054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057700_0_0_2"/>
    <dbReference type="OMA" id="WLLANEN"/>
    <dbReference type="OrthoDB" id="75744at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="3">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="33132" checksum="B6DCAC8ED6A784F8" modified="2007-02-06" version="1">MPVQLNVDTFAFRRRKGFVLSPVSAVKVLESPTGEFELPVDIGLGIARAVKTVSEVSLNLEGATHRLTLGILERLAGSDKLLYVGPEGVYFVEVRDEKGYYKLKYLGERVAPTLEINGVHMHNITGIDPLSDAERKVRMLGVARGEKVLDVCTGLGYTAIRALERGAEVVSIEKDPNVLYIAEHNPFSEKLSRASILLGDAFDVVGELPEEYFDKVLHDPPVFAFAGHLYSAEFYTRLWRVLKKGGRVFHYTGAPGKHRGVNIQRGVVERLRRAGFRIVRVIKDYGVIAEKPRRSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ7</accession>
    <name>A1RXJ7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csl4</name>
        <name evidence="5" type="ordered locus">Tpen_0521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752192.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0521"/>
    <dbReference type="EnsemblBacteria" id="ABL77927">
        <property type="protein sequence ID" value="ABL77927"/>
        <property type="gene ID" value="Tpen_0521"/>
    </dbReference>
    <dbReference type="GeneID" id="4601359"/>
    <dbReference type="KEGG" id="tpe:Tpen_0521"/>
    <dbReference type="eggNOG" id="arCOG00676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_1_1_2"/>
    <dbReference type="OMA" id="CGNVETR"/>
    <dbReference type="OrthoDB" id="111542at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="188" mass="21132" checksum="8BE99EF4751B6842" modified="2007-02-06" version="1">MREDRVVIPGENVGVAEEYLPGENVYVDEETGDLKAKRVGVLKEERAQHIVKVFPFKPDGQLGKGDVVYAVVKQIRDPVAIVEIFYVENKRRKLIPPLTGILHVSNASSSRVRLLSDVIGYGDVIRATIADEGGPPYYLSIRGREFGVVVAKCPSCMTPMRKRGVILLCPNCRYKTRRRKVSSRYMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK3</accession>
    <name>A1RXK3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0527"/>
    <dbReference type="EnsemblBacteria" id="ABL77933">
        <property type="protein sequence ID" value="ABL77933"/>
        <property type="gene ID" value="Tpen_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0527"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_2"/>
    <dbReference type="OMA" id="PYVDVNI"/>
    <dbReference type="OrthoDB" id="113968at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="784" mass="90340" checksum="5D3CD83BF0F6C8BA" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL1</accession>
    <name>A1RXL1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ordered locus">Tpen_0535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752206.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0535"/>
    <dbReference type="EnsemblBacteria" id="ABL77941">
        <property type="protein sequence ID" value="ABL77941"/>
        <property type="gene ID" value="Tpen_0535"/>
    </dbReference>
    <dbReference type="GeneID" id="4601048"/>
    <dbReference type="KEGG" id="tpe:Tpen_0535"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="OMA" id="QFNEGAK"/>
    <dbReference type="OrthoDB" id="111461at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10075" checksum="26D3F7CA3392E65A" modified="2007-02-06" version="1">MSLAEGSVLVGNKSVMNYVLAAVIQFNQGAKKVSIKARGRAISRAVDVAEIVRSRFLKDEVDVSSIKIGSEKVGEAGKERTISTIEIVLERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM3</accession>
    <name>A1RXM3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752218.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0547"/>
    <dbReference type="EnsemblBacteria" id="ABL77953">
        <property type="protein sequence ID" value="ABL77953"/>
        <property type="gene ID" value="Tpen_0547"/>
    </dbReference>
    <dbReference type="GeneID" id="4600504"/>
    <dbReference type="KEGG" id="tpe:Tpen_0547"/>
    <dbReference type="eggNOG" id="arCOG04166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093718_0_0_2"/>
    <dbReference type="OMA" id="YAAFYSA"/>
    <dbReference type="OrthoDB" id="57080at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018693">
        <property type="entry name" value="DUF2192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09958">
        <property type="entry name" value="DUF2192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="235" mass="27061" checksum="CB812148BC55EB20" modified="2007-02-06" version="1">MQEVHRKRIEVAINVWGEILEKTFENREQLVSYLEAVYRENRLEPIRGKTRINIYDKELATLYLVGKYGLALEDEISSFSDLFHVEIKADKVLSRVLSGEDPRNAVVSEFGSTEEDNVFRVLRLAMTAVVLGFMDEETFIRVLESFEKAFPELDRNFTSFKRFYIAFRLAEKIAAGEIRNRLEKEAYKHALCVKLNAEKAAPPDSFIRDIAVNALKVPEFKVNSALSLHAHERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS8</accession>
    <name>A1RXS8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0603"/>
    <dbReference type="EnsemblBacteria" id="ABL78008">
        <property type="protein sequence ID" value="ABL78008"/>
        <property type="gene ID" value="Tpen_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0603"/>
    <dbReference type="eggNOG" id="arCOG04214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_2"/>
    <dbReference type="OMA" id="WQHRHGS"/>
    <dbReference type="OrthoDB" id="85388at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="15695" checksum="D4FA582D8E608979" modified="2007-02-06" version="1">MGNFKVVVREISLSTRRKLELIDITAQVERVAAESGIRNGVCLVFAPHATAAIIANEHEEGLLKDIEGKISELFPVDQPYLHNRIDDNAHAHIASSFIGASLVLPVVNGRLLRGTWQNIFLVELDGPRSSRKVVVEVMGESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV0</accession>
    <name>A1RXV0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="6" type="ordered locus">Tpen_0626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752295.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0626"/>
    <dbReference type="EnsemblBacteria" id="ABL78030">
        <property type="protein sequence ID" value="ABL78030"/>
        <property type="gene ID" value="Tpen_0626"/>
    </dbReference>
    <dbReference type="GeneID" id="4601413"/>
    <dbReference type="KEGG" id="tpe:Tpen_0626"/>
    <dbReference type="eggNOG" id="arCOG01037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_2"/>
    <dbReference type="OMA" id="ADFRFWL"/>
    <dbReference type="OrthoDB" id="110333at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="187" mass="21275" checksum="7ADE9DF61E964D83" modified="2007-02-06" version="1">METLRLVVAVSGTPGSGKTTYARFIAERYNLRYVSSGSLFREMAKKLGVDLIRLHSMAEENEDIDRAVDSRAIEEAKKGNVVIEGHLAVWLLKDIADVKVIFDAPLEVRARRIAQRESIPLEKALEEIKIREKSNYERARRYYNLDIRDYTVADLVVNTYPLDVEAVKSVVAAFIDGYLRARMRIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY10</accession>
    <name>A1RY10_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidyltransferase-related domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752355.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0688"/>
    <dbReference type="EnsemblBacteria" id="ABL78090">
        <property type="protein sequence ID" value="ABL78090"/>
        <property type="gene ID" value="Tpen_0688"/>
    </dbReference>
    <dbReference type="GeneID" id="4601888"/>
    <dbReference type="KEGG" id="tpe:Tpen_0688"/>
    <dbReference type="eggNOG" id="arCOG01222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212640_0_0_2"/>
    <dbReference type="OMA" id="LGPDQWI"/>
    <dbReference type="OrthoDB" id="79845at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF357" evidence="3">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="225" mass="25358" checksum="38C74A90DFEE2A73" modified="2007-02-06" version="1">MEREGKCEEKAERYIANVERALESLKVVLPEGGVEETLRLVRGYVSDARFYLEKGDCETSIACSSYAEGLLDALRFLGRVTFEWPSVPSRRKRVLVGGVFDLLHPGHIYFLRRASELGNVYVVVARDKTVIDTKGRQPLFSEEERLEMLKALKFVSDAFLGDYPPNFANALRRVKPDIVFLGADQGGLLPIVEKAVQEAGLNVEIKVLDKRLNDYSSTKYKSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY11</accession>
    <name>A1RY11_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ordered locus">Tpen_0689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0689"/>
    <dbReference type="EnsemblBacteria" id="ABL78091">
        <property type="protein sequence ID" value="ABL78091"/>
        <property type="gene ID" value="Tpen_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0689"/>
    <dbReference type="eggNOG" id="arCOG04161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OMA" id="TAGDPMV"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="287" mass="31529" checksum="999873E6A39C26F2" modified="2007-02-06" version="1">MLVVAGLGLCGTRDISVGLLREAEDADEIFLETYTSVSPGLRVEDLVSVLGRGVKLVTRKDLEDESARTVLEVAARGKALLLTIGNPLIATTHSSIVVEAAKRGIKVRVLPAPSIIDGIIASTGLHVYKFGRVVSLVFPEDPSLKNYPYTPYSVLKDNVSRGLHTIFLLDIRADEGRYMLFREASELLLRLEERFQENVVDENTLVIGVARATAEDEKVFAGRISEAINADLGNAPHTLIVPGELHDSEIDFLHYKTGRPVEVFKSWNAKVNAKKKQSGTSPTWREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY25</accession>
    <name>A1RY25_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0703"/>
    <dbReference type="EnsemblBacteria" id="ABL78105">
        <property type="protein sequence ID" value="ABL78105"/>
        <property type="gene ID" value="Tpen_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0703"/>
    <dbReference type="eggNOG" id="arCOG00933">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_2"/>
    <dbReference type="OMA" id="RCDIHYA"/>
    <dbReference type="OrthoDB" id="13164at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="144"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="609" mass="70490" checksum="E451702D4E288F9F" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY27</accession>
    <name>A1RY27_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0705"/>
    <dbReference type="EnsemblBacteria" id="ABL78107">
        <property type="protein sequence ID" value="ABL78107"/>
        <property type="gene ID" value="Tpen_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0705"/>
    <dbReference type="eggNOG" id="arCOG14996">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204250_0_0_2"/>
    <dbReference type="OrthoDB" id="113188at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="112" mass="13582" checksum="C79014AEC5A572F9" modified="2007-02-06" version="1">MQSSRTIEEKQKLLEHLASVVEELLRNTKSSQISIKLRTLLRYAYVSYVKKTSDINVIRGLVPRVRPPAWLTNQYYYREIELMLKTRFNARIENRRQFRYVVLYKNPSNFRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY32</accession>
    <name>TFE_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor E</fullName>
            <shortName evidence="1">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tfe</name>
        <name type="ordered locus">Tpen_0710</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752377.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY32"/>
    <dbReference type="SMR" id="A1RY32"/>
    <dbReference type="STRING" id="368408.Tpen_0710"/>
    <dbReference type="EnsemblBacteria" id="ABL78112">
        <property type="protein sequence ID" value="ABL78112"/>
        <property type="gene ID" value="Tpen_0710"/>
    </dbReference>
    <dbReference type="GeneID" id="4601591"/>
    <dbReference type="KEGG" id="tpe:Tpen_0710"/>
    <dbReference type="eggNOG" id="arCOG04270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="OMA" id="DSGWLTY"/>
    <dbReference type="OrthoDB" id="75288at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000326625" description="Transcription factor E">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <sequence length="178" mass="20575" checksum="3515BAD4F3F757D8" modified="2007-02-06" version="1">MNAHEALAEIAGKMFGDNAKKVMMVLASNVEVSDEDLAKDLKMDPPELRKLLNDLFEARLVKYRRARDENIGWYKYYWRITDEPIQQILSDRKRLTLSILEKVLSLEENSETYVCPKCGTRYTVDEAENNNYTCEVCGEVLEPFDNTHRVEKLKRAIELLGNWDPSPKQQASRAIPHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY70</accession>
    <name>Y748_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein Tpen_0748</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0748</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752415.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY70"/>
    <dbReference type="SMR" id="A1RY70"/>
    <dbReference type="STRING" id="368408.Tpen_0748"/>
    <dbReference type="PRIDE" id="A1RY70"/>
    <dbReference type="EnsemblBacteria" id="ABL78150">
        <property type="protein sequence ID" value="ABL78150"/>
        <property type="gene ID" value="Tpen_0748"/>
    </dbReference>
    <dbReference type="GeneID" id="4600399"/>
    <dbReference type="KEGG" id="tpe:Tpen_0748"/>
    <dbReference type="eggNOG" id="arCOG01336">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_2"/>
    <dbReference type="OMA" id="RGCIGFP"/>
    <dbReference type="OrthoDB" id="107157at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000082711" description="Protein Tpen_0748">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <sequence length="213" mass="23797" checksum="5030B2F09DAA1A3C" modified="2007-02-06" version="1">MGRLSAEEGALLVRLARRAVEEYLENARVIEPPRDTPPSLREKSGVFVTIEKILVDPLARRARRELRGCIGYPEPVLPLAEATIHAAIAAATEDPRFPPMTPRELDTVVFEVSVLTKPEPVDYRSPEELPDKIKVGRDGLIVEYGAARGLLLPQVAVDEGWDPEEFLSYACLKAGLRDDAWRHGGLKVYRFQAQIFVETTPKGDVVERFLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY74</accession>
    <name>A1RY74_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752419.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0752"/>
    <dbReference type="EnsemblBacteria" id="ABL78154">
        <property type="protein sequence ID" value="ABL78154"/>
        <property type="gene ID" value="Tpen_0752"/>
    </dbReference>
    <dbReference type="GeneID" id="4600403"/>
    <dbReference type="KEGG" id="tpe:Tpen_0752"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_2"/>
    <dbReference type="OMA" id="TFCGYFA"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="310" mass="32868" checksum="EC8C54A5B536510E" modified="2007-02-06" version="1">MGKPRFAVSGNANLDVYLVVERIPGPDEAVEAVETRSYVGGAATNVAVALARLGVYARFLGFVGGDDEGARVLKELGGNGVDTGYVQMSSLPTGRVIVLLDRQGRRAMVALRGANTELKPGCFNAESVLGGVDHLHLSSTHPGYTAWLLQEAKRLGLSTSWDPGMAVVSRSPQEVLKAARSADVLFLNEREYEALRGGLAELGETLVVVKRGEEGSEAPRLGVKVKAFRVSPVDTTGAGDTFDASFLVAWKLGLSVEDCLLLGNAAGALKVTRMGAHSSPTLRELYDFLSSRVESGEALPRLAGLFRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY90</accession>
    <name>A1RY90_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fmu (Sun) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752435.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0768"/>
    <dbReference type="EnsemblBacteria" id="ABL78170">
        <property type="protein sequence ID" value="ABL78170"/>
        <property type="gene ID" value="Tpen_0768"/>
    </dbReference>
    <dbReference type="GeneID" id="4601090"/>
    <dbReference type="KEGG" id="tpe:Tpen_0768"/>
    <dbReference type="eggNOG" id="arCOG00975">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_6_2"/>
    <dbReference type="OMA" id="HAYVFEI"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="4">
        <location>
            <begin position="165"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="443" mass="49806" checksum="8B1D460266DD52F3" modified="2007-02-06" version="1">MSSSEAFLEDLTPKTFRAASLVVERVQRWKASLDYSFQSVRKEFNLSKPEARTVYALARLTLLNVGVAILALKKLGRSGIPLRRKSAFYVAVALVLKYPGFEKRVESLRGGLVSNVLLSSITPRFLERLIEEARELGCRDRIAYLYSVPPLVSEVLVENLGCARAEEVARSFERRFVWLRAVGEKGREKLEEFLVGLGIRFRRDPEIDGLYELLLPSYEPLPEVSPELAVYQDKASVAVVMELVKLGETCVSTCIDAAAAPFMKTSLYCDARRCCDEILAVDISFNRIRDSRGVLLGCRKIVHIVNSDSRFLATRTLFDEGLVDAPCTNSGAIGKDPGLRLSLWELDREEVALYSTRQREILRNVLRHMKHGGRVAYSTCSVLPEEGEEVVKDVAADGESSLLRPPLFFDEAYPRYGLRGVATRTFPDKHRSEAFFIALLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY99</accession>
    <name>A1RY99_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752444.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0777"/>
    <dbReference type="EnsemblBacteria" id="ABL78179">
        <property type="protein sequence ID" value="ABL78179"/>
        <property type="gene ID" value="Tpen_0777"/>
    </dbReference>
    <dbReference type="GeneID" id="4601838"/>
    <dbReference type="KEGG" id="tpe:Tpen_0777"/>
    <dbReference type="eggNOG" id="arCOG01812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978686_0_0_2"/>
    <dbReference type="OMA" id="MNSYERF"/>
    <dbReference type="OrthoDB" id="8417at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSF" evidence="6">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="31370" checksum="04DA040957CA3176" modified="2007-02-06" version="1">MVRSERLLRLYIQSTLGAFEKYYVKAGFETPFSLYVSYLSRALVAVGAAVFAASLAVHLFLLRFAVPLAFAASVTLTVLAEVLVVFVALYYPVYRVYSRRITIEKDLPFTASYMAALSSSGMGLERLLERAVLYESNKEIKREIALILRDIKAYGLDTLTALSRAALRSPSRSLAMLWLGLRETYITSGNFKSYLSHFSGVLLSEKTQSLRRVTNTISMMAEVYTTLMVAAPLMFVTMLVIMDMLGGTVFGLSPGILVLVLTFVVVPFSALGVYVAIDGILSRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD7</accession>
    <name>SYE_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">Tpen_0816</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752482.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYD7"/>
    <dbReference type="SMR" id="A1RYD7"/>
    <dbReference type="STRING" id="368408.Tpen_0816"/>
    <dbReference type="EnsemblBacteria" id="ABL78217">
        <property type="protein sequence ID" value="ABL78217"/>
        <property type="gene ID" value="Tpen_0816"/>
    </dbReference>
    <dbReference type="GeneID" id="4601986"/>
    <dbReference type="KEGG" id="tpe:Tpen_0816"/>
    <dbReference type="eggNOG" id="arCOG04302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_3_2"/>
    <dbReference type="OMA" id="MRFAPNP"/>
    <dbReference type="OrthoDB" id="8922at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000001982" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <sequence length="569" mass="64322" checksum="BCA13B7C3A20DCB9" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI8</accession>
    <name>A1RYI8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0867"/>
    <dbReference type="EnsemblBacteria" id="ABL78268">
        <property type="protein sequence ID" value="ABL78268"/>
        <property type="gene ID" value="Tpen_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0867"/>
    <dbReference type="eggNOG" id="arCOG01395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067068_1_0_2"/>
    <dbReference type="OMA" id="NSSYCNG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="39957" checksum="8707775674FE8724" modified="2007-02-06" version="1">MRVWVEALTPKQVLLFSYLQHELPGYEFFLTTRDYDLNRELAGKLWKEYYVVGRHGGRTPRGKVAESLRRQASLLRLVESKNPDAHVTFVSPDSARVAYGVGIPVVACNDTPHSTIVSRLVIPLAEVLVVPQPVAAYFEDYARLTRISPFRGVFEVAWVARTQPDERVPRSLGLEPLNYVIVRTGEEKAFYYKEPRAALEVPLRMTRYILRKTDMKVLLYPRYPEQKTALAKGLSGYEGRLVFLERAEVLVHLEFFARLVITGGGTIATESALLGTPAITTFPGRVEVHEYLRANGFPVYSGVTLENLPRILRADQSIEGKMKVKAKASKLFQDPVRHIAKELQSILTEKMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ9</accession>
    <name>A1RYJ9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ordered locus">Tpen_0878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752544.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0878"/>
    <dbReference type="EnsemblBacteria" id="ABL78279">
        <property type="protein sequence ID" value="ABL78279"/>
        <property type="gene ID" value="Tpen_0878"/>
    </dbReference>
    <dbReference type="GeneID" id="4600360"/>
    <dbReference type="KEGG" id="tpe:Tpen_0878"/>
    <dbReference type="eggNOG" id="arCOG04287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OMA" id="EYIYAAM"/>
    <dbReference type="OrthoDB" id="128352at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="108" mass="11675" checksum="7AF04B1E99AE4AC0" modified="2007-02-06" version="1">MEYVYASLLLYHAGKEISEENVKRILEAAGIQVDDVRVKALVAALKEVNIEEALKTAALPVAVGAPAPATAPAQAPPAEEKKEEKKEEKKEEVKEETVEEGLASLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL6</accession>
    <name>A1RYL6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase hexapeptide repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752561.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0895"/>
    <dbReference type="EnsemblBacteria" id="ABL78296">
        <property type="protein sequence ID" value="ABL78296"/>
        <property type="gene ID" value="Tpen_0895"/>
    </dbReference>
    <dbReference type="GeneID" id="4600472"/>
    <dbReference type="KEGG" id="tpe:Tpen_0895"/>
    <dbReference type="eggNOG" id="arCOG01848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_9_1_2"/>
    <dbReference type="OMA" id="MFANDMF"/>
    <dbReference type="OrthoDB" id="93082at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="21826" checksum="767F0A25DD6C9BD5" modified="2007-02-06" version="1">MSSSRKYFAHPTAVVEEGAEIGEGTRIWHFAHVRSGARIGRNCNIGKDVYVDQGAVIGNNVKIQNGVSVYRGVVIEDNVFVGPYAVFTNDKYPRAFSTDWEVVPTVVKEGASIGANATIVCGVTIGRYAMVAAGSVVTRDVPDHALVAGNPARIVGFVCYCGRPLKRLVGERDGNVVLQCDHCGREVSIPKSIYEKALEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ1</accession>
    <name>A1RYZ1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4234 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1021"/>
    <dbReference type="EnsemblBacteria" id="ABL78421">
        <property type="protein sequence ID" value="ABL78421"/>
        <property type="gene ID" value="Tpen_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1021"/>
    <dbReference type="eggNOG" id="arCOG06137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257200_0_0_2"/>
    <dbReference type="OMA" id="PIANIYW"/>
    <dbReference type="OrthoDB" id="137596at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025328">
        <property type="entry name" value="DUF4234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14018">
        <property type="entry name" value="DUF4234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4234" evidence="2">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12855" checksum="23D16B7D9788C5AF" modified="2007-02-06" version="1">MGATTPGQKKVPEKRSLLKVYALIFLTFGVYFYLWLVWTKRELNALGARIPTCWLIIIPIANIYWLYKYAEGFAQVTKKESAVLYFLVFWLFTIVMPAIVQSELNKIAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ16</accession>
    <name>A1RZ16_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752711.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1046"/>
    <dbReference type="EnsemblBacteria" id="ABL78446">
        <property type="protein sequence ID" value="ABL78446"/>
        <property type="gene ID" value="Tpen_1046"/>
    </dbReference>
    <dbReference type="GeneID" id="4600789"/>
    <dbReference type="KEGG" id="tpe:Tpen_1046"/>
    <dbReference type="eggNOG" id="arCOG01696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_2"/>
    <dbReference type="OMA" id="YVHLKGP"/>
    <dbReference type="OrthoDB" id="17268at2157"/>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="426" mass="46481" checksum="08B60633C2241E67" modified="2007-02-06" version="1">MKLVYLVLDGVADKPEDGPTSLEVARKPALDGVASKSACGLVYTVGRGVAPESDAAVFSILGYDPHTEYTGRGPIEAVGAGLEIREGFEVAFRANFATVDPETRRIIDRRCGRNLSSEEARELARALDGVDLGVHDGYARVVATVGHRAVVVIGSRSRRLSDNVGNTDPAYEKRGYVSVAKPSFEPFVAEARPLDDSEEARRTADLVNAFTELSIRVLRGHPVNMARAREGKLPANAILLRDSGGRLPRLQRISEKYGLRFGAVAEMPVEIGIARILGMDMASVPPPSEDKAKDYADRLEATLKLLERNDVVYVHLKGPDEPGHDGDLKRKVEAIEAIDKYYLAPLLREIDPATTALLVTADHATPYTRKSHTDDPVPLALMAPGVTPDGVPRFTEKECSRGSLGVFEHGYEVLPRLLERLRRVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ28</accession>
    <name>A1RZ28_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752723.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1058"/>
    <dbReference type="EnsemblBacteria" id="ABL78458">
        <property type="protein sequence ID" value="ABL78458"/>
        <property type="gene ID" value="Tpen_1058"/>
    </dbReference>
    <dbReference type="GeneID" id="4601444"/>
    <dbReference type="KEGG" id="tpe:Tpen_1058"/>
    <dbReference type="eggNOG" id="arCOG00213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_2"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="OrthoDB" id="40323at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="4">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="367" mass="38909" checksum="09E7A25CF941D8CF" modified="2007-02-06" version="1">MPLTSRGAALTVLLVGLALAAVLWIGSQQAQREVLLKGSGATFPMPQIQAWAYRFTSKHPGIKIEYAGVGSGQGISDFLNGIVDFAGSDVPLNDQQYSAARSRFGEVYQLPYILGGVAVVYNVPEIKGAGNLRLTGEVLADILLGKIAYWDDPRIRELNPGLNLPHKEIVLVYRSDASGTNEVFTKYLSYVSPEWRKTVGAGKTVQWPLAGLGRAVGAKGNPGVAQAVNSTPYALGYVELAYTKGLGVAAIRNKSGNFVLPTPRSVTIAASALPALDPSSSIAGVNYLEAIFGNPDPDAYPISTPTFLVVKGPKNYDPPKAKALALFLKYIATEGQSPESIVEGYAPVPQQLREAILRVAAILEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ29</accession>
    <name>A1RZ29_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752724.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1059"/>
    <dbReference type="EnsemblBacteria" id="ABL78459">
        <property type="protein sequence ID" value="ABL78459"/>
        <property type="gene ID" value="Tpen_1059"/>
    </dbReference>
    <dbReference type="GeneID" id="4601445"/>
    <dbReference type="KEGG" id="tpe:Tpen_1059"/>
    <dbReference type="eggNOG" id="arCOG00167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_2"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="OrthoDB" id="37194at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="66"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="298" mass="31336" checksum="AE671480745263D6" modified="2007-02-06" version="1">MELDALRLVLAPVALVLLLAVGSMVVVLARESIPVLAREGLAILTSNAWRPSEDPSEELYGVAVPVLGSLYTAALALALVALFSLSLTVFVEEVAPRPLRAALEEALNVAASVPTVVYGLWGLSTVVPAVRWLGRTLGMEGVSGPSILSASIVLATMITPYAAAMMLVAYKSVPLAYVEAVTSLGATRVERARIILGMIRGFFAASLLIGFGRAVGETTAVSMVVGNVYNLSPNVFEPSYTVTSLIANQFGMAYYYRYLPSALYFAALLLLAVSSIATYAGLRLASRAGLPAHRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ34</accession>
    <name>A1RZ34_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator, PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1065"/>
    <dbReference type="EnsemblBacteria" id="ABL78464">
        <property type="protein sequence ID" value="ABL78464"/>
        <property type="gene ID" value="Tpen_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1065"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="HSWRIAQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="316" mass="35821" checksum="C742D5CE5A7D24A8" modified="2007-02-06" version="1">MLVAYARKLIRLGKSSLAVTLPSKWLKRHSLREGDVVYLEEREEGLLVAPGLREQRERLEQARVELAPGEEESAERMIISFYQAGYSEIRIVYSGGRMPAGLLSQVRGSLARLVGLEVFEEGENYVQLQMVADTSTMSLERILSRMEILVKNDVRDLEDYYEEKDSSYLRSVVERDVELDKFYFLLSRQVALSLKSSSYAEKIGVKSRPLLLPYFNYGKTLERVGDVLVSIARALLAGESIAKSHLYTARRAVENGINVFRTGDKASKSSLVNLYSRYFSTTHRQSLVDYLVGNLLSLSLDMLESRIDLEALEKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ36</accession>
    <name>A1RZ36_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752731.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78466">
        <property type="protein sequence ID" value="ABL78466"/>
        <property type="gene ID" value="Tpen_1067"/>
    </dbReference>
    <dbReference type="GeneID" id="4601645"/>
    <dbReference type="KEGG" id="tpe:Tpen_1067"/>
    <dbReference type="HOGENOM" id="CLU_155677_0_0_2"/>
    <dbReference type="OrthoDB" id="138903at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14874" checksum="796DD8B0927388B1" modified="2007-02-06" version="1">MTTVKMGGVFLARRRVGRGVVRAYFVVFADGRMVKNLAERDARGGFSGEAEVEFRERLTILAKAGPSGFEGMRPGGVWYSVTFVSSDTHRRIELSLPLLDEKVSITVEGRVDLEKITSCGWYDASSLINLVQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ59</accession>
    <name>A1RZ59_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752754.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1090"/>
    <dbReference type="EnsemblBacteria" id="ABL78489">
        <property type="protein sequence ID" value="ABL78489"/>
        <property type="gene ID" value="Tpen_1090"/>
    </dbReference>
    <dbReference type="GeneID" id="4602130"/>
    <dbReference type="KEGG" id="tpe:Tpen_1090"/>
    <dbReference type="eggNOG" id="arCOG07451">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089975_0_0_2"/>
    <dbReference type="OMA" id="VDVMPAT"/>
    <dbReference type="OrthoDB" id="77551at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="27132" checksum="E75CBF3DA475178E" modified="2007-02-06" version="1">MVQDVYTEFYRGVVGIFDRILREEKLNLEKASEVLAHTLKSGGFIYVFGTGHSMLMAMEVFYRAGGLVRVYPLLDLSVSGFNGALKSTYMERLPGYAKALLDSTPIKPNSSLIIVSNSGKNAVPVEMAVEARNRGVKVIAITSVEYSRKVPPSNPLGKRLYEVADVVIDNKVPEGDAILKIEGCEQKVAPVSTIVCSFILQLLVARTVQKLLSAGVKPEVWMSANVPGGDEANKRYLEKYFESLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ92</accession>
    <name>A1RZ92_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase subunit D</fullName>
            <ecNumber evidence="8">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752787.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1124"/>
    <dbReference type="EnsemblBacteria" id="ABL78522">
        <property type="protein sequence ID" value="ABL78522"/>
        <property type="gene ID" value="Tpen_1124"/>
    </dbReference>
    <dbReference type="GeneID" id="4602019"/>
    <dbReference type="KEGG" id="tpe:Tpen_1124"/>
    <dbReference type="eggNOG" id="arCOG04162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103639_0_0_2"/>
    <dbReference type="OrthoDB" id="115719at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="114" mass="12130" checksum="D319B56F746528A2" modified="2007-02-06" version="1">MPSGKSGVAWFLQAVTGAVLALAVSAHIVRVHLLGSAHGIPTYEEVLAALKNPLVMLGELVLAFSATYHALYGLHMVLVESKLLSEEKSRKVLTALGIALATWIVAFNVLVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA6</accession>
    <name>A1RZA6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1138"/>
    <dbReference type="EnsemblBacteria" id="ABL78536">
        <property type="protein sequence ID" value="ABL78536"/>
        <property type="gene ID" value="Tpen_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1138"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076093_0_0_2"/>
    <dbReference type="OMA" id="WAWELRW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="25957" checksum="2F6A6AC2883942DA" modified="2007-02-06" version="1">MGRRKAVLWLHLMRSKRYALSLVSGSLTDALWMIILLAGFILAGKAPEASSNYWGLVAWTILSNATWMIGGWVDYLVLLGLVEEHEVRGVSVFELVAGRAIPMLASSAISSLAAYAFLSLAGARVSVASIPVLASSLALLYAQSLCYGLLLASLSLRTGTPSYMLDILSLAFLGLAFSPTPASPSVALIPLLGPMLLAKLSSTGSVQPAAVAYGVPATLFLAVAALLACRSTEEHARRRGVRAVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC0</accession>
    <name>A1RZC0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1152"/>
    <dbReference type="EnsemblBacteria" id="ABL78550">
        <property type="protein sequence ID" value="ABL78550"/>
        <property type="gene ID" value="Tpen_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1152"/>
    <dbReference type="eggNOG" id="arCOG00151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_2"/>
    <dbReference type="OMA" id="IEGNWIT"/>
    <dbReference type="OrthoDB" id="14823at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="393" mass="43701" checksum="C820A6137FB1B338" modified="2007-02-06" version="1">MIRFAGWSAGETEMKNYQKIIEDFQKANPDIIVKYEVITQMFSENILASYAAGAAPDIFYVDSAWAPTFISKGALYPIGDKLPKDFIDQFYPFLLEPFKGPDGKIYGLPKDWSVLSLFYNKKLFAQAGVPEPTADWTWDDLFNAAKTIYQKTGKPGLVVHAELNRWVPFLVSNGAPPPRFDSAADAAYFDKPEVRNAISKMIAKIQEGRKEGYIVLPSDVNAGWNGEAFGKQLAAMTIEGSWMIPYLADQFPNFKYGSDWDLAMLPKGPAGRASMAYTVALGVNSKTENLDAALKFLQYVEGIEGQKLLVVKMGHTLPSIKALANDPDLWPSHAKELSFVNKYDRVALFFYGPKTGQIEGSINQIIQSAVRGEITIDEALRLMKDKVAEAFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD8</accession>
    <name>A1RZD8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752833.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1170"/>
    <dbReference type="EnsemblBacteria" id="ABL78568">
        <property type="protein sequence ID" value="ABL78568"/>
        <property type="gene ID" value="Tpen_1170"/>
    </dbReference>
    <dbReference type="GeneID" id="4601184"/>
    <dbReference type="KEGG" id="tpe:Tpen_1170"/>
    <dbReference type="eggNOG" id="arCOG06075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125813_0_0_2"/>
    <dbReference type="OMA" id="WYPFVKL"/>
    <dbReference type="OrthoDB" id="121541at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="140" mass="15973" checksum="DA64BC59D5084559" modified="2007-02-06" version="1">MRGTERLEEGLSQNGVYVYGAGRWVLSEKIPLDADGFYVVYFSNTMCGACRKFNETWFKLTKELSGATFVVVLCDWFARSCRSETAKRLFEIFDVHVSPTLVFLVRENGKITRMYKHEGTITAEGFLAVFDAFKRALGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH1</accession>
    <name>A1RZH1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752866.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1203"/>
    <dbReference type="EnsemblBacteria" id="ABL78601">
        <property type="protein sequence ID" value="ABL78601"/>
        <property type="gene ID" value="Tpen_1203"/>
    </dbReference>
    <dbReference type="GeneID" id="4600405"/>
    <dbReference type="KEGG" id="tpe:Tpen_1203"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_2"/>
    <dbReference type="OMA" id="IAMFIDV"/>
    <dbReference type="OrthoDB" id="49249at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="59"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="465" mass="49881" checksum="DAF665E9A0EA54C4" modified="2007-02-06" version="1">MVVERAASQQYAFRVLLVLVAGLVTALASSLLGLEAQQVLALTAFLMTIYATLLLWTYRLPFAFLGVSALFLLGVLDVEYFVEHSHLDVIAFLIAMMTIVGYLEEDRFFEFIAQEIVRRVGVNFRATFLVVVFLSGFLAPLVDEVTSILVMLSVVLPLSGKIGVDPLPLVIASIFATNIGSAMTPLGNPVGVLVAFESGLTFSDFLARAAPVSALSLVVAAAILMHLFRGYIEEGNALASQRFTDGWSVASLERRTLYRDASVFSATILFIAAHHVLEEALGLPKNSLLLAAPLMVAGLIMLLDPSRGFHALETKVEWPTLVFFLLLFASVGALEKTGVVEVLSKSLGSLSASGVGAFMGAFTLSSSLMSAFMDNVIAVAILSRVVHELGAQGFHTEPFWWLTLFSAVYAGNLSPIGSTANIVALSVLEKRLGRSAGFKEWLRVGLPVTAATLALGFAAVYLQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK7</accession>
    <name>A1RZK7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752902.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1239"/>
    <dbReference type="EnsemblBacteria" id="ABL78637">
        <property type="protein sequence ID" value="ABL78637"/>
        <property type="gene ID" value="Tpen_1239"/>
    </dbReference>
    <dbReference type="GeneID" id="4601171"/>
    <dbReference type="KEGG" id="tpe:Tpen_1239"/>
    <dbReference type="eggNOG" id="arCOG01091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996132_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="30153" checksum="F493D17B4E1909CE" modified="2007-02-06" version="1">MSFEVQDLYDVIKISILLALEDDPRLRLDELESRLRELYGNEVGLDPAEIRKALSELSGEGLVVCKDGVLELTEAGLKISEDWRNLLLKSEPVLEVVAGLTDGTVTGLITVISSHLAGLSSKLTVFASLLALTSVAVTNFSSFFLGGVTEDLSEVVALRRLMAYSLSDHPDKRQVSRSLKLLGRLYRVLYREIRRANVLSAALSGVATLAAGFVPIALYLALPPPFNLLASIAVVSAAILALAKYRSSAARTHFKRTLAETLLVILLVVLVSLLLGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS1</accession>
    <name>A1RZS1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752966.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1303"/>
    <dbReference type="EnsemblBacteria" id="ABL78701">
        <property type="protein sequence ID" value="ABL78701"/>
        <property type="gene ID" value="Tpen_1303"/>
    </dbReference>
    <dbReference type="GeneID" id="4601597"/>
    <dbReference type="KEGG" id="tpe:Tpen_1303"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697603_0_0_2"/>
    <dbReference type="OMA" id="FDLHAQY"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="395" mass="42014" checksum="391BC8CA6EA58FFC" modified="2007-02-06" version="1">MGKGSLSFYISLYIVVFITMIDHSTISPIVAQYAKSLGASDSLAGIIVASYSMSALISLPVVGLLLDKVSRAGVVQSLILADLAVVYLYTLPRSPTELLVVRALHGAVDSALFPGILAVFRDMVTRRLETGFTLYWVVTGTPIAIGSLLARTVVLHYGFRGVFYALIPLYVAGLIASIEISRRYREALARRALWEGPRDPVALGTLVAAYVSAYILYTGIGTVVGSMSISLTRGLGLPREAAAAEVAWWAFQATLFSLLVMAFTARHVVREVSKALWALAIGLSGVALSMGLLLVSIESLSRTLSSLFFGVALGTVLPASSKIVSDTHYKYRGRASALLSVSFLTGVITGAVASSRLLETAHGLYTNYLPAAAGASLGLLLVLYVASRRRASRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS6</accession>
    <name>A1RZS6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78706">
        <property type="protein sequence ID" value="ABL78706"/>
        <property type="gene ID" value="Tpen_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1309"/>
    <dbReference type="eggNOG" id="arCOG03722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121773_0_0_2"/>
    <dbReference type="OMA" id="FYHNYMG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="192" mass="21686" checksum="0258699EBEBDEFBD" modified="2007-02-06" version="1">MGKVEELLAEWPEVAGVCARLAAGERLGEGEAVVKEVAEAAGWGVDDVVEDLARIGVDPSGRVERYRELFEKYYAEALELKRRGDARQAGEKLWGAVTALIKLYAAEKGVFVAHWSTGKLDRFVTSNVGKEHRKLFRDLIDKAHRLHENFYEGSLDPETLEERWAEALDLLEKAKRIVLDERRSEKTRQAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS7</accession>
    <name>A1RZS7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752972.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78707">
        <property type="protein sequence ID" value="ABL78707"/>
        <property type="gene ID" value="Tpen_1310"/>
    </dbReference>
    <dbReference type="GeneID" id="4601604"/>
    <dbReference type="KEGG" id="tpe:Tpen_1310"/>
    <dbReference type="eggNOG" id="arCOG01439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971889_0_0_2"/>
    <dbReference type="OrthoDB" id="95395at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="144"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="29077" checksum="24A011455168576F" modified="2007-02-06" version="1">MGSVVVVELSLRAVSGGSLPWFSGAECRGALLSAVGAVDGGVAGLMHGKPGSPSVFALRPLRFASGFRVVGEGVSAGVLFERGALARMEVAFLDEGVARRAVAAIASTRSFSVKGQEFALEGLALRVYDPARVLEAGPFEALDVRFHTPTYFNPLSGDKEYKVLYPDPVHMLAGLVATAHRLTGASLPKPEELASTVYVAGLDVKTPPMEPSKPAPNGFVGWVKLKARKNAPSDKLSLVHGLLKLGELTNIGGNRSAGYGVITVKTANQPSKTTPEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV2</accession>
    <name>A1RZV2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752997.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1335"/>
    <dbReference type="EnsemblBacteria" id="ABL78732">
        <property type="protein sequence ID" value="ABL78732"/>
        <property type="gene ID" value="Tpen_1335"/>
    </dbReference>
    <dbReference type="GeneID" id="4601310"/>
    <dbReference type="KEGG" id="tpe:Tpen_1335"/>
    <dbReference type="eggNOG" id="arCOG03723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142665_1_0_2"/>
    <dbReference type="OrthoDB" id="128052at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="15466" checksum="7ACBAEA800392CEA" modified="2007-02-06" version="1">MDTARTTRLIEEAENLLRVALEEFEKGVKEGSDEAIRDSAEKAWRAVAKAADALLLAKGFSEENIETHRQKRLALEELAAKDPEVARQGFKDRFMAREYTLHVRCFYDGEYTLSSLREELEKARQFVEDVKKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX2</accession>
    <name>A1RZX2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1355"/>
    <dbReference type="EnsemblBacteria" id="ABL78752">
        <property type="protein sequence ID" value="ABL78752"/>
        <property type="gene ID" value="Tpen_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1355"/>
    <dbReference type="eggNOG" id="arCOG01441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579555_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010184">
        <property type="entry name" value="CRISPR-assoc_prot_MJ0385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09703">
        <property type="entry name" value="Cas_Csa4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="471" mass="52014" checksum="7DA9579FFEE3E309" modified="2007-02-06" version="1">MERAQTRRHRVPLHGGGRVRREVPGREEEGRQDPVPGPRSRRDAGQERRGCLREDERRAQGAEDVRGPGVQGLRARWTREGPRVQARLRGDRVPRGGRGLRVEPRGHRAEGVRATPTLYTPGHSPYTDTLIMHALARAAWGARDAALRVRGTGFEYVLETSVDARTLAYELRRTFEEVHAAFLDRQRLGRLFQDKDVRLLDSALDPEGLRAFLEGELSRPGHAGAEGRGFDGLTFKLPLMPSAGKYLHTDLTRKPKYEAKEYRVCKYCAALAALGLASSVYVARGARVLVVTLAFSGEAGYDALGGYYDFLQGEEAKDVLGVLGPRVDNVPERLLAQLAVALLTRNALEALDHAGATWRVYAVKFDTGRAVQVRGFYDVEVDSVVGAMSSLARVDDASYSKLRDMLKQLARATGADSPRAGYALEALSRLFEFFETASPDSLYGFARSVYCAYEGKAGFHGVVESLVRAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX6</accession>
    <name>A1RZX6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1359"/>
    <dbReference type="EnsemblBacteria" id="ABL78756">
        <property type="protein sequence ID" value="ABL78756"/>
        <property type="gene ID" value="Tpen_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1359"/>
    <dbReference type="eggNOG" id="arCOG01423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_2_1_2"/>
    <dbReference type="OMA" id="TWDENQR"/>
    <dbReference type="OrthoDB" id="65708at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012431">
        <property type="entry name" value="PDDEXK_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07788">
        <property type="entry name" value="PDDEXK_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="242" mass="28687" checksum="63A6F2E49C0C0C22" modified="2007-02-06" version="1">MAVQALKAELLRLLREDEEFRLAVAGLLGLDTVLGELKKLREDFNKLVELENRRWEENSKRWEENWRMWEENSKRWEENNKRWEENNRKWEEAYKRFEAIEAELKGLREDFNRGFDELRRRIDALGARWGIASESAFREGMRGVIERILGAGKVERWMYYDREGEVYGHPAMVEVDVAVKDGEHILIEVKSSVSRGDVAVFRRIGELYEKVNRVKPRLIMVSPYVDPRALEDARILGVEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ4</accession>
    <name>A1RZZ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1377"/>
    <dbReference type="EnsemblBacteria" id="ABL78774">
        <property type="protein sequence ID" value="ABL78774"/>
        <property type="gene ID" value="Tpen_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1377"/>
    <dbReference type="eggNOG" id="arCOG03776">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032977_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="269" mass="30221" checksum="D68B66E11EFD279B" modified="2007-02-06" version="1">MAEKGQVRSPASLVGLIVLLLLAVVFLWNPLVAMILLLILFLYSVFVVIVAKVALKEERILEKLKEMDASMPERPEAVLLDPDEVVVLRGHAGLCSAEGQAQEFPLTLVLPKVYLTGKRLIIEGVAERPFENQRLEVHESILLEQIVGVKVLKEKSPIPELLVTTKLRGYWSRFRLEIPGAQTWRDEITRLRAERVRSLEKREKPAVDFSSIRDILERGGVVVYTVKCPVCGAPLKLPETGRETKCSYCGATVYAEDVLGKLKELLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S005</accession>
    <name>A1S005_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S8 and S53, subtilisin, kexin, sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1388"/>
    <dbReference type="MEROPS" id="S08.105"/>
    <dbReference type="EnsemblBacteria" id="ABL78785">
        <property type="protein sequence ID" value="ABL78785"/>
        <property type="gene ID" value="Tpen_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1388"/>
    <dbReference type="eggNOG" id="arCOG00702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_0_2"/>
    <dbReference type="OMA" id="FSTRRWY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="160"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="444" mass="46736" checksum="4BB27915C06D46A8" modified="2007-02-06" version="1">MHFLDVRLGRLFELSRLYVYTYIKLLYSNWKAPPMRKAVLVLLVLVLLIPVLQVTTAPATNKVRVVVGYENEGALAAVEGLPGAEKVKVLREIKAAVFYLPPEAIEKAKGIKGVRYVEEDKVAVALELSSYPDVLWDVKMINASKVWDKYYPVYGWKALGRGVVVAVLDTGIDYTHPELKGKVVWCANTVGVKTYTGTKLSNCADRNGHGTHVAGTIASAINGVGNAGVAPNVTLYAVKVLNDAGSGTYSDIAEGIIIAVKGPDGVAGTSDDAKILSMSLGGSSDSQVLYDAVKWAYSNGAVLVAAAGNSGDGDPTTDNVAYPARYSEVIAVAAVDSNANVPTWSSDGPEVDVAAPGVNVYSTYKNGGYATLSGTSMATPHVSATVALIQALRLAAGKQPLTPSQVYDVLTKTAKDINSPGFDVFTGYGLVDALAAVDYALSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S039</accession>
    <name>A1S039_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753084.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1422"/>
    <dbReference type="EnsemblBacteria" id="ABL78819">
        <property type="protein sequence ID" value="ABL78819"/>
        <property type="gene ID" value="Tpen_1422"/>
    </dbReference>
    <dbReference type="GeneID" id="4600718"/>
    <dbReference type="KEGG" id="tpe:Tpen_1422"/>
    <dbReference type="eggNOG" id="arCOG02105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_2_2"/>
    <dbReference type="OMA" id="WENETYL"/>
    <dbReference type="OrthoDB" id="108900at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="123" mass="14382" checksum="7F1478A1D73C432B" modified="2007-02-06" version="1">MDPAETWEELRPVFEKHGVLFAYLFGSRARGLERENSDWDFAVYFGREVTVVDEARLEDDPEKATGLKVDVVALDNAPLDFVYVVLRDGVPVYSRDERLRKSWEIEAYLEYLDYEAWISSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S059</accession>
    <name>A1S059_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753104.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1442"/>
    <dbReference type="EnsemblBacteria" id="ABL78839">
        <property type="protein sequence ID" value="ABL78839"/>
        <property type="gene ID" value="Tpen_1442"/>
    </dbReference>
    <dbReference type="GeneID" id="4601151"/>
    <dbReference type="KEGG" id="tpe:Tpen_1442"/>
    <dbReference type="eggNOG" id="arCOG01448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021650_0_0_2"/>
    <dbReference type="OrthoDB" id="83629at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="281" mass="31391" checksum="C358C0490A3F308D" modified="2007-02-06" version="1">MVVTVHYVGFHPRLILEGFERVRLRHPVERVYLLYDGKPDKYGAVSRYNVKRLAEVLSFFKPVLVKVNPLSQESIASQVYQVLLHEKRLGASEVLIDVTDMPPLMVAVVSTVALMFPNCRLYAVQPEQIGAFIPDPETPEFADFIRAKDNLTASDLKTVDRPRVSLEVIDDGEGGEEARRVLVTLYVKGSADSITTLIRWVTGLPPDRKPDPTLKASYSRLVSELEERGLVVRRHEGRNRSVELTDLGKAIAEAYLKLGETPSPKLPPLPMPKPATTLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S091</accession>
    <name>A1S091_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753136.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1474"/>
    <dbReference type="EnsemblBacteria" id="ABL78871">
        <property type="protein sequence ID" value="ABL78871"/>
        <property type="gene ID" value="Tpen_1474"/>
    </dbReference>
    <dbReference type="GeneID" id="4601575"/>
    <dbReference type="KEGG" id="tpe:Tpen_1474"/>
    <dbReference type="eggNOG" id="arCOG01469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1145265_0_0_2"/>
    <dbReference type="OMA" id="YPITYIP"/>
    <dbReference type="OrthoDB" id="118156at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC2_membrane" evidence="5">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="26530" checksum="5420A9E6C83B93B8" modified="2007-02-06" version="1">MRRSRLWRPLGVAYAELILWRRQWMWIAQDAVWTLSLPLIFYFWGGLKALKSLVVASFVATGWTVGVNLVGQTVGWQRVSRIQEALVASPLSPSDYFVGTVLGQIPYFLTEYTAFTLLALWLEVSPAGVAALYALSFASLVLGSFLSLAVVLRIKNPMNISAVTNPLVTVTIILPPVWYPLSALPEVARLPALLAPTAALAELARWVAGLGCMDPAVPLLVTFVWIAGTGVALKSALHWGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A6</accession>
    <name>A1S0A6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753151.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1489"/>
    <dbReference type="EnsemblBacteria" id="ABL78886">
        <property type="protein sequence ID" value="ABL78886"/>
        <property type="gene ID" value="Tpen_1489"/>
    </dbReference>
    <dbReference type="GeneID" id="4601284"/>
    <dbReference type="KEGG" id="tpe:Tpen_1489"/>
    <dbReference type="HOGENOM" id="CLU_1324077_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="207" mass="21621" checksum="C62EEDE5B948F98D" modified="2007-02-06" version="1">MRKLSRLLCEVTAPGAGRVRLSPAVALAAAFSGSLAALLAPAASLPLVLAASALLSLTVAGARRTAAAILLSAPFLGFYAVSSTAAQLLLGFFDPLYAASTLARHLSVVLLSYTAFSAVSVADLLRLVGRLSPGLAAELALAYKLAYTASLTLRQLGELYGVNLGGRRARRLVALSKSLTYLTALHTLYMLEALYTRRVVAGWTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E8</accession>
    <name>A1S0E8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ordered locus">Tpen_1532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1532"/>
    <dbReference type="EnsemblBacteria" id="ABL78928">
        <property type="protein sequence ID" value="ABL78928"/>
        <property type="gene ID" value="Tpen_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1532"/>
    <dbReference type="eggNOG" id="arCOG05865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_2"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="OrthoDB" id="37571at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="44"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="257"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="397"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="284"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="636" mass="71521" checksum="3010F38E884088F2" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F8</accession>
    <name>A1S0F8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PaREP7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753203.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1542"/>
    <dbReference type="EnsemblBacteria" id="ABL78938">
        <property type="protein sequence ID" value="ABL78938"/>
        <property type="gene ID" value="Tpen_1542"/>
    </dbReference>
    <dbReference type="GeneID" id="4600835"/>
    <dbReference type="KEGG" id="tpe:Tpen_1542"/>
    <dbReference type="eggNOG" id="arCOG01426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055579_0_0_2"/>
    <dbReference type="OMA" id="CYDPLVV"/>
    <dbReference type="OrthoDB" id="106474at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="317" mass="37243" checksum="A93A7F62DA87A022" modified="2007-02-06" version="1">MAALGRREWERLIKALEEDRELRYALAGLLGFRDLLEKMDATLSEIKALREGQEQLWRKQEKLWGEVRKLWEEVRALREDQRKLWEEVKALRENQEKLWEEVKSLREGQGKLWEEVKALREDQRRLWEEVKALRENQEKLWEEVRALREDQGKLWEGQQRLWEEVRALREGQERLRGDVDGLRASFRQLGEAVGMTLEFYAAAFLERLLAEKGYPEARVRVGVNLAYKGVLVELDLFCEEPLLVGEVTTYLRSAEDAEREAAKLMERVKVVEEISGRKVELAVLAVANLGREALEVLEKLHREKGVLVVTGRELEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I1</accession>
    <name>A1S0I1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753226.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1566"/>
    <dbReference type="EnsemblBacteria" id="ABL78961">
        <property type="protein sequence ID" value="ABL78961"/>
        <property type="gene ID" value="Tpen_1566"/>
    </dbReference>
    <dbReference type="GeneID" id="4601524"/>
    <dbReference type="KEGG" id="tpe:Tpen_1566"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_659942_0_0_2"/>
    <dbReference type="OMA" id="FITHAHA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="232"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="441" mass="48678" checksum="4C0E4844DC8961BE" modified="2007-02-06" version="1">MRLVFLGGYREQGRSCLALEHGGRYYVFDVGVKKVYSGGKYGEPPFLGLIDAGKVEAVFVSHLHEDHLAAVPALVRRGFNGPIYMSAPTAELGIKQWYKWTVLEEDGKPLFTEEDCDEARKMVKTVGDGSVVTSGDVEVAFHQSGHALGSMYMEVSVGGWSMLYAADINRGSSVFRDPAPAPSSYDVVIANASYGDRVVDAGVGERRVAALVLETVKRGGTALIPVTAVGRGQETLMILLRSREILGSGAPIFVEKSIAEGVERVAAYEGYVKPEFLEVAKRKPHLAEPFHVFSKDEVDEVARVKPSVVLATDLMLMETSRRFFEKLREDPSSSVILTGYQAPGTFGRRLLDHREAGAFTFNGEVVRFSCRVYDVPVKMHFDVRDNVELVQRTLKEEGLVVLHHGEEPNSTRLALHLFNYVKPERVVVPQVPSDLYLVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L2</accession>
    <name>A1S0L2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1597"/>
    <dbReference type="EnsemblBacteria" id="ABL78992">
        <property type="protein sequence ID" value="ABL78992"/>
        <property type="gene ID" value="Tpen_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1597"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_1_2"/>
    <dbReference type="OMA" id="NAHPERT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8685" checksum="E797A7910B117F03" modified="2007-02-06" version="1">MGVFRGAEKVVKALYQCLGIEIWGYSVSKMLEHLPSELKPSQEIIDASKELDRHYIPTRYPNAHVEGAPMDYYTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N8</accession>
    <name>A1S0N8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753283.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1623"/>
    <dbReference type="EnsemblBacteria" id="ABL79018">
        <property type="protein sequence ID" value="ABL79018"/>
        <property type="gene ID" value="Tpen_1623"/>
    </dbReference>
    <dbReference type="GeneID" id="4601026"/>
    <dbReference type="KEGG" id="tpe:Tpen_1623"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="15"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="338" mass="36829" checksum="904F7AE8FA96C4EF" modified="2007-02-06" version="1">MYKIAVVNSRSFGVIAPDVLQKLQEVAQIDFIDVEKTLRGKALAEKLEGYHFIIASVTPLYDREFFENNRSLLLIARHGIGYDNVDVDAATEQGVIVTRVPGSRERDAVAELAVALCLNVARKVCQAATLVREGKWAERGKIVGVNISGKTVGIIGLGNIGSRVAEIFSRGFNAKVVAYDPFVGKDYAARFGAELVDLDTLLRESDIILLHAPLTKETYHMIGEKEIDKMKKGVIVVNTARGELIDTNALIKGLESGKIAGVGLDVVEGEPIGADHPLLKYRNVVITPHIGANTYEGLRGMDEANADAILKVIRGEAPLEYMVNPEVLKRGTRANLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T7</accession>
    <name>A1S0T7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1672"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79067">
        <property type="protein sequence ID" value="ABL79067"/>
        <property type="gene ID" value="Tpen_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1672"/>
    <dbReference type="eggNOG" id="arCOG05411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429428_0_0_2"/>
    <dbReference type="OMA" id="VGPHVYR"/>
    <dbReference type="OrthoDB" id="7875at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="entry name" value="PTHR31451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="640" mass="73057" checksum="3E88A76AE0F77F03" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U4</accession>
    <name>A1S0U4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1679"/>
    <dbReference type="EnsemblBacteria" id="ABL79074">
        <property type="protein sequence ID" value="ABL79074"/>
        <property type="gene ID" value="Tpen_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1679"/>
    <dbReference type="eggNOG" id="arCOG00182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="QYFPIKG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="320" mass="34999" checksum="0A14748D1FF2A2FF" modified="2007-02-06" version="1">MNTILQVRDARIYYAVKGTEVKAVDGVSFEVHEGEILGIVGESGSGKSTLLNSLVNVRPPMKYIGGDALFDGKNLYRMSKEEKKSVLGTRLTIIPQYALDALPPVFRIKQYLADFAKTHGLSESEIIKLARERLKEVSLSEKVLDMYPIELSGGMRQRVAIVIASLTSPRLLLGDEITSALDVVTQKGIMLNIRRFVDEGLIGSAVLVTHDISLIYQVADTIMVMYAGKVAEIAPAEEIAKKPLHPYTNMLISSLTKLGVKASQQRLSGIKGLPPSLANPPPGCRFAPRCPYAVGRCKSEEPPAKNVDGHLVACWLRGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U5</accession>
    <name>A1S0U5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1680"/>
    <dbReference type="EnsemblBacteria" id="ABL79075">
        <property type="protein sequence ID" value="ABL79075"/>
        <property type="gene ID" value="Tpen_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1680"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="QARCRRV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="324" mass="36548" checksum="59DCE1E3E164ED2D" modified="2007-02-06" version="1">MVELLRLENVTKEYSRGLFGGTRFRAVEDVSFKVDKGKILALIGESGSGKTTIARIILRILRPTSGRVIFEGKDIFAFDAEESAAYYRNVQGIFQDPYSSFNPLKTVDDILELTCKKYTCSEYPENAIKQVLERVGLDPQSVLGKFPHQLSGGQLQRVSIARALLVKPRLLVADEPVSMLDASTRVDILNILYDLKTGENISTLLITHDVSQAYYVGDEIVVLYRGHVMERGDATILEKPLHPYTTNLLASVPTLSSRWATEEKIRAARLRLEAEEETVYTTTGCKYASRCPYASEKLGCFTRKPPEIEVEPGHFVRCWLYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W0</accession>
    <name>A1S0W0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753355.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1695"/>
    <dbReference type="EnsemblBacteria" id="ABL79090">
        <property type="protein sequence ID" value="ABL79090"/>
        <property type="gene ID" value="Tpen_1695"/>
    </dbReference>
    <dbReference type="GeneID" id="4601018"/>
    <dbReference type="KEGG" id="tpe:Tpen_1695"/>
    <dbReference type="eggNOG" id="arCOG08357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2434026_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="10464" checksum="01745146D9B515B2" modified="2007-02-06" version="1">MKVKVTLSLDRDLVSRVKSRLAFEGRSLSELVEELLSMYDVEAFVRDLCRDLGVECRYFSPQEVVSGRVRGLRAEDVVREVRYGREERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W8</accession>
    <name>A1S0W8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1703"/>
    <dbReference type="EnsemblBacteria" id="ABL79098">
        <property type="protein sequence ID" value="ABL79098"/>
        <property type="gene ID" value="Tpen_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1703"/>
    <dbReference type="eggNOG" id="arCOG03233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040623_0_0_2"/>
    <dbReference type="OMA" id="VWITTHS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="298"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="457" mass="49403" checksum="DFF2A95F62D31193" modified="2007-02-06" version="1">MGMPVNARVYVRDFGPFEEASIEVRPLTVLVGRNSVGKSMLLQLVWALTVAMPDLKLLGEAVSELGAGELVGEVLEGVEKGSASRDSFKRLLKLYLEALPGALATGLGRTLEEVFGAGLQELVRSGSGRAVVGVAGSFSSIEFVIEGGRLAVSRHKPYEGFLDELEVTVPAPGRLRIIHRLSGVSLYDEAVLSPSDLVDAVLKVLAIYLYKALDIFFEAPGVSVLLPDSRAGLSRILLKPYARPSLLKDVLYPDEHFRDAYFMLAESLAEGKVDTGDLEDFLRELGCSVEAIPEGGVRAVYVNTWSGQRLPLPRAPSGVRESLAVALALVVPEQPWLVFIEEPEAHLHPRAQKALARLIARAVKKHGKVVVLSTHSDYLLYAVSNMVALSSSPGVAERLGYSAAEVLDPGLVAAYLLRAEGRRAVVERLDVGPEGVPEEEFVRVAEELAEERARILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z4</accession>
    <name>A1S0Z4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753389.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1729"/>
    <dbReference type="EnsemblBacteria" id="ABL79124">
        <property type="protein sequence ID" value="ABL79124"/>
        <property type="gene ID" value="Tpen_1729"/>
    </dbReference>
    <dbReference type="GeneID" id="4601754"/>
    <dbReference type="KEGG" id="tpe:Tpen_1729"/>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420154_0_0_2"/>
    <dbReference type="OrthoDB" id="132576at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021478">
        <property type="entry name" value="DUF3131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11329">
        <property type="entry name" value="DUF3131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="639" mass="68774" checksum="E6212BF49F0D7E87" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S109</accession>
    <name>A1S109_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1744"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79139">
        <property type="protein sequence ID" value="ABL79139"/>
        <property type="gene ID" value="Tpen_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1744"/>
    <dbReference type="eggNOG" id="arCOG01411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_2"/>
    <dbReference type="OMA" id="ASKYWIN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="167"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="343" mass="38740" checksum="7A18270B87FD784B" modified="2007-02-06" version="1">MKVLLTPHVEHYTVGLAGELSRRIKVELLAFARYPVSARQMVVPRLPVPGHRDLLYKYALKALARRYDVVHVNTASHGALLGPRDNLLLTEHGWPEPELVEREQRRFYEKERESLLQLYEAGVPVVTISNFSARMLRERLGVKATAVVYHGVLDTFRRNKPLEPPIHHVVLWNSRLVGFKEPFTFLEAIRLVKGKASFEAVIRGDGPLKREVEGYLRRHGLEDTVRFAERIPFEKLPQLYRSATIFIHTCSKEPFGLAVLEAMASGLPVIVPDAGGAAEVAGDAGLKFRPGDSEDLAEKLLVLLTDQQLYETFSARSIERSAFFTWEKAASTYLDLYRKISGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S142</accession>
    <name>A1S142_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1777"/>
    <dbReference type="EnsemblBacteria" id="ABL79172">
        <property type="protein sequence ID" value="ABL79172"/>
        <property type="gene ID" value="Tpen_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1777"/>
    <dbReference type="eggNOG" id="arCOG04583">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1418754_0_0_2"/>
    <dbReference type="OMA" id="AWIERIQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="191" mass="20806" checksum="0C44955D5F30D7BB" modified="2007-02-06" version="1">MPSGAPGQRLLRLLYRFVPQAYYRSKAREVPYSPMLIDVGSGRGLFLGSLAGRYGFAVGVDVDAELVKASPRSPHACYVVASACMLPFRDSCFDTAVFHDSLHHFVRPFDALEEALRVSRKSVLIFDYDGGGALARIIATVEKALGFPASFLQASMLAERYGARVRVGRLGSMTAEIDAGSWRKKPSSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S145</accession>
    <name>A1S145_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753440.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1780"/>
    <dbReference type="EnsemblBacteria" id="ABL79175">
        <property type="protein sequence ID" value="ABL79175"/>
        <property type="gene ID" value="Tpen_1780"/>
    </dbReference>
    <dbReference type="GeneID" id="4601924"/>
    <dbReference type="KEGG" id="tpe:Tpen_1780"/>
    <dbReference type="eggNOG" id="arCOG07750">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567259_0_0_2"/>
    <dbReference type="OrthoDB" id="131742at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="170" mass="19024" checksum="2C0912E31D989737" modified="2007-02-06" version="1">MSGDIESSILSSEKVKLEMRDFEEWFKRYGDYLLAYEPSKVVVRTAWIARVMLDEGYALYPGREEEVRKAVAGILVGKLEELGVPRGAIRKGDLKGSRQDVVEVLKIVYPNVSQTDRPSLPAVIAQEREAKVAEARFSAFSPRNPGSKYIYAYLATLVLSALLIALLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A0</accession>
    <name>A1S1A0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1835"/>
    <dbReference type="EnsemblBacteria" id="ABL79230">
        <property type="protein sequence ID" value="ABL79230"/>
        <property type="gene ID" value="Tpen_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1835"/>
    <dbReference type="eggNOG" id="arCOG04488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122673_0_0_2"/>
    <dbReference type="OMA" id="WKEEVYF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="245" mass="27666" checksum="635789B778BCA6E4" modified="2007-02-06" version="1">MGMYLRIIFGGSREIPVYVSDPSYHDALRKALPIESTAELWKEEVYFSTNLDLRGPTSSRVPSGTFAYWPPGKALCLFAWVSQPYGAVIPLGWLLGPKHYVLLLDKESSVRVEESRLEEYPERVQAAVRILREAGFLAAPRTWNGVLSITGASVKRDTRVGFEVFVEEHGYIIESDPVFKRDFSPLDEALQLRIKAHLVKSRVDVNEEGYVILSDYAPTVQDLVERISRVVSEYQKVIDVMSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A4</accession>
    <name>A1S1A4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="3">P5C reductase</shortName>
            <shortName evidence="3">P5CR</shortName>
            <ecNumber evidence="3 4">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">proC</name>
        <name evidence="7" type="ordered locus">Tpen_1839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753499.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1839"/>
    <dbReference type="EnsemblBacteria" id="ABL79234">
        <property type="protein sequence ID" value="ABL79234"/>
        <property type="gene ID" value="Tpen_1839"/>
    </dbReference>
    <dbReference type="GeneID" id="4602075"/>
    <dbReference type="KEGG" id="tpe:Tpen_1839"/>
    <dbReference type="eggNOG" id="arCOG00455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_4_1_2"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="70966at2157"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="5">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="6">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="30557" checksum="E46450A5CD9926EA" modified="2007-02-06" version="1">MTLEGLSSVAILGAGKIGGAFVRQILQKTGIRVYATGRRVETLRGAESLGAVATRDNDEAVRRSELVVIAVKPYHFPQLLSEVKQESWKGKIVVSLMAGVKLATLRAALHGAKVFRAMPNLNAYVGKSSTAVSENLYDDASRTVEEFLGLFGQVYWVPEEYLDVWTGLAGSGPAFIAEVLDALAMGAVAAGMPRELSYKAVLDVLEGTAILLKNGFYQHPAMLRDDVTTPAGTTIRGLMVLESGGVKATLMKVIEAAARRSREIGNEIDSRIREKINSRIGHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B4</accession>
    <name>A1S1B4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751369.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1849"/>
    <dbReference type="EnsemblBacteria" id="ABL79244">
        <property type="protein sequence ID" value="ABL79244"/>
        <property type="gene ID" value="Tpen_1849"/>
    </dbReference>
    <dbReference type="GeneID" id="4600348"/>
    <dbReference type="KEGG" id="tpe:Tpen_1849"/>
    <dbReference type="eggNOG" id="arCOG13820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629913_0_0_2"/>
    <dbReference type="OrthoDB" id="126926at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="77" mass="8688" checksum="F35E442F9EA7807C" modified="2007-02-06" version="1">MARYKSARVGERGEPKPRCCVCGSEDVCAKIEGKFYCYKCGSRIIVEHSRRIVEELVAKYLGEKLLTQDDPFNWGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B6</accession>
    <name>A1S1B6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1851"/>
    <dbReference type="EnsemblBacteria" id="ABL79246">
        <property type="protein sequence ID" value="ABL79246"/>
        <property type="gene ID" value="Tpen_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1851"/>
    <dbReference type="eggNOG" id="arCOG15169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2839559_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="65" mass="8210" checksum="D030C33638CB11A4" modified="2007-02-06" version="1">MGLRDWLRRGGLEVEFEDEEELVEAPPGLEEEEEPWEEWESEEEYWEQPPRVRKWWWEESEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1E5</accession>
    <name>A1S1E5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1880"/>
    <dbReference type="EnsemblBacteria" id="ABL79275">
        <property type="protein sequence ID" value="ABL79275"/>
        <property type="gene ID" value="Tpen_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1880"/>
    <dbReference type="HOGENOM" id="CLU_2379581_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="94" mass="11227" checksum="92DB4C482B4E3D9A" modified="2007-02-06" version="1">MKTTVRVKRSTEYNWSEPSFPMVFCDVTFKNGEEEVWRTVDYIIARWNRLLYVYEESETHYTEEDVAESVRVKIKKVGFFSPSPPFSPWFRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F1</accession>
    <name>A1S1F1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751406.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1886"/>
    <dbReference type="EnsemblBacteria" id="ABL79281">
        <property type="protein sequence ID" value="ABL79281"/>
        <property type="gene ID" value="Tpen_1886"/>
    </dbReference>
    <dbReference type="GeneID" id="4600322"/>
    <dbReference type="KEGG" id="tpe:Tpen_1886"/>
    <dbReference type="HOGENOM" id="CLU_2730612_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="71" mass="7948" checksum="313D47082E6D14E0" modified="2007-02-06" version="1">MPSTLQLQGLSLVETIPVTTTDYADYNFSKLNPNECVVFWFQKNRVAVLVCNIGNGYYRVATKPVPPTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW43</accession>
    <name>A1RW43_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751688.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0013"/>
    <dbReference type="EnsemblBacteria" id="ABL77423">
        <property type="protein sequence ID" value="ABL77423"/>
        <property type="gene ID" value="Tpen_0013"/>
    </dbReference>
    <dbReference type="GeneID" id="4601059"/>
    <dbReference type="KEGG" id="tpe:Tpen_0013"/>
    <dbReference type="eggNOG" id="arCOG00174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_2"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="OrthoDB" id="71481at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="291"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="497" mass="53745" checksum="C779FF6E617DA9C1" modified="2007-02-06" version="1">MLALLIAVSASLARMAEAYIVSLLIALVLGSLMARNKVVESIMLPVLDILQSIPILGFFPAALAMFIANLPRALGVEAAAVFLIVTSLVWNMIFGVYASIKSLEPSVFDMARVYSLGAVSRFFYIYVPASRAALLANSLISWAGGWFFLTAAEVITLGEEEYKLTGIGAFIMESYNRGDYASFYIGVAALFATIMATYVLLWNPAVKSVRDLPLPSVSAFYEKFSEVVSRVWSGLGEALVWVEARVKLPGFVPRVVGATLLVVALFYLGSGVAGLLSLDVVGVAKSFLHELPLSLARVSIVLVFSLVLSLLIAYLTYSFRRAAMLIGASGELLASVPAIIWWPLLGYVALTFSWGPLVVLFTVLLQGSLWYLYFNILVFGLGSIRKEHEELAAVYGVKGWHFFRSIFFPSVFPSLLTGALSSWGGAWNATIAAEYVTLGQRTIDLGGVGALLNRYTVEGEAGKTALAALFLSLVIVAVDKAVWARLFSRLSGKFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW71</accession>
    <name>A1RW71_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751716.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0041"/>
    <dbReference type="EnsemblBacteria" id="ABL77451">
        <property type="protein sequence ID" value="ABL77451"/>
        <property type="gene ID" value="Tpen_0041"/>
    </dbReference>
    <dbReference type="GeneID" id="4600982"/>
    <dbReference type="KEGG" id="tpe:Tpen_0041"/>
    <dbReference type="eggNOG" id="arCOG00946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="39920at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="79"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="362" mass="41378" checksum="9C648C13AD628C17" modified="2007-02-06" version="1">MSDKLLGKPFVREAAFWEPVQGKPGYVKCNLCNRRCVIAPGRFGVCGVRKNIDGKLYTLVYGLLTAANLDPIEKKPLSHFYPGSAVFSVSTPGCNFFCQFCQNWEISQSRLERGLYGHYYPPEDVVREAKRLQADGISYTYNEPTIFYEFMLDTARLAKKEGLFNTMVTNGYISPEALDELAPYLDAATVDFKGGGDPEFYRKFMGVPDPSPIYDTLLRMKEKGIHVEITNLVVPIVGDDEEKLRSLARWVAENLGDETPFHLLRFYPHYKMIDYPPTEVGDLEKLAGVAREEGLKYVYIGNVWGHPLENTYCPKCGHRVIERRGFFIVKWDLTEDNRCPVCGAKINIKGSYRKRSWDVFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW82</accession>
    <name>A1RW82_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751727.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77462">
        <property type="protein sequence ID" value="ABL77462"/>
        <property type="gene ID" value="Tpen_0052"/>
    </dbReference>
    <dbReference type="GeneID" id="4600532"/>
    <dbReference type="KEGG" id="tpe:Tpen_0052"/>
    <dbReference type="HOGENOM" id="CLU_1912436_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14555" checksum="344D21B09EB58A11" modified="2007-02-06" version="1">MASRVVVELRFKGSGEPLTFELEPGRTVEVELGNRSPETLVYRFTLRRIEGFVSYTIVKLEAGGKTSYVGRSTKPGVTLEVLVHPGESGALRLGAVSPRTSEDDFKVEIEVTVERVAAATLPEKAPVLRAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW85</accession>
    <name>A1RW85_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0055"/>
    <dbReference type="EnsemblBacteria" id="ABL77465">
        <property type="protein sequence ID" value="ABL77465"/>
        <property type="gene ID" value="Tpen_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0055"/>
    <dbReference type="eggNOG" id="arCOG03871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145192_0_0_2"/>
    <dbReference type="OMA" id="ANNQWIV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="16432" checksum="CFFF26EE56051703" modified="2007-02-06" version="1">MMAAQKRRGISPVIATVIIVAVTIAIAIAVAFWMTGIVGIFTGTVEKLEIVSLYAVPNAQGGWDVTVIVKNTGTISTSIDNIFINGVPVKNCNPAITPNPDVTATPQPLKPGGDPLTITFTLGNGNECGGTKFTSGVSIEVKLHSTGGKEYPKLITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW86</accession>
    <name>A1RW86_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751731.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0056"/>
    <dbReference type="EnsemblBacteria" id="ABL77466">
        <property type="protein sequence ID" value="ABL77466"/>
        <property type="gene ID" value="Tpen_0056"/>
    </dbReference>
    <dbReference type="GeneID" id="4600984"/>
    <dbReference type="KEGG" id="tpe:Tpen_0056"/>
    <dbReference type="eggNOG" id="arCOG10986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044535_0_0_2"/>
    <dbReference type="OrthoDB" id="141108at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14102" checksum="D31C6EB5FF370A75" modified="2007-02-06" version="1">MQNRATDIRGFRAEKAVEVPGEVVVLVVVVAVAVAAAFWLANMATQQMGLEILDLKASASRSGGKTVVTVYAWNRGTKPATIVAVKVNGQVYEQRVAVEPGSSASITVEAPPADALEVVVVTASGREYPLIVGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW88</accession>
    <name>A1RW88_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin/glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751733.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77468">
        <property type="protein sequence ID" value="ABL77468"/>
        <property type="gene ID" value="Tpen_0058"/>
    </dbReference>
    <dbReference type="GeneID" id="4600970"/>
    <dbReference type="KEGG" id="tpe:Tpen_0058"/>
    <dbReference type="eggNOG" id="arCOG04235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095574_0_0_2"/>
    <dbReference type="OMA" id="KMWLLAK"/>
    <dbReference type="OrthoDB" id="105723at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="254" mass="28242" checksum="ED6962D66F205269" modified="2007-02-06" version="1">MLTVYVHPRCADSYRVYRLLSSRTPQSTRITYLDTEKYPFRALEYGVFSVPAFSLNGRLVLQGYFEDEEVVSLASGAGLRVSSLDEAFSRLLKSVYYSLTVASAVYVAGDLSVVAGSKSYLMSASGAFFVPEGEKFPEYAARRLSQTPFSEVEQGLLRNIAGNFARDLYWLTGEVPTRERVEKLGEGFFEAWLLARASIGRVFVPQSSPRPGLRERVSKAWSYVLGVIDKAGARVKEEQESIPQGWVEEASAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC6</accession>
    <name>A1RWC6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0096"/>
    <dbReference type="EnsemblBacteria" id="ABL77506">
        <property type="protein sequence ID" value="ABL77506"/>
        <property type="gene ID" value="Tpen_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0096"/>
    <dbReference type="HOGENOM" id="CLU_1870849_0_0_2"/>
    <dbReference type="OrthoDB" id="139911at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="13968" checksum="2003AFA2017AA400" modified="2007-02-06" version="1">MNASFLGSLLKVLYNRLTLTKGQIALASRLLASEVFGPAPESKLTVIDAASKALSYLGLRAEVSIEKGVLTVSLPCPATECVLREICPVPYFVAASVDLLSGVKCYPVQGGNGTVVSLSDGKCTFKLRVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD6</accession>
    <name>A1RWD6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine recombinase XerA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xerA</name>
        <name evidence="7" type="ordered locus">Tpen_0106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'phage' integrase family. XerA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751781.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0106"/>
    <dbReference type="EnsemblBacteria" id="ABL77516">
        <property type="protein sequence ID" value="ABL77516"/>
        <property type="gene ID" value="Tpen_0106"/>
    </dbReference>
    <dbReference type="GeneID" id="4600854"/>
    <dbReference type="KEGG" id="tpe:Tpen_0106"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_2"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02055">
        <property type="entry name" value="Recomb_XerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033686">
        <property type="entry name" value="XerA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2 3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="34166" checksum="22580609A6ABFA38" modified="2007-02-06" version="1">MSSVKAPFAERSNDELIDLYISHLVARNRSEKTIKSFKSILEEFVRFLGDRHVSQVTVYDVDFFLAHLRRKGWKKDSIYTAAVAVKRFLEFLGLGGNIAGFELPKREKRLPRYLEAEEVFRMVNAAENLRDKLIVLLLFTTGLRVSELVSLRVSDVDLEKRTLRVRGKGSKERLVYFPDYVADLLRSYMKGLNSEWLFPSETAEHIHYTTVERVLKRLKEKAGIEKKVTPHTLRHSFATLSLAAGLDIREIQELLGHSNLNTTQVYAHVSRERLKRDYERVWSSLLDPRSAKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG5</accession>
    <name>A1RWG5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
            <ecNumber evidence="2">3.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0135"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77545">
        <property type="protein sequence ID" value="ABL77545"/>
        <property type="gene ID" value="Tpen_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0135"/>
    <dbReference type="eggNOG" id="arCOG03278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033691_0_0_2"/>
    <dbReference type="OMA" id="GWRSPNY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="518" mass="60587" checksum="2A597229F9D2B3AB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWH3</accession>
    <name>A1RWH3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH:sulfur oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0143"/>
    <dbReference type="EnsemblBacteria" id="ABL77553">
        <property type="protein sequence ID" value="ABL77553"/>
        <property type="gene ID" value="Tpen_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0143"/>
    <dbReference type="eggNOG" id="arCOG01069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_2"/>
    <dbReference type="OMA" id="ITHAPCG"/>
    <dbReference type="OrthoDB" id="40511at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="48328" checksum="C1BCADD8DAE864F0" modified="2007-02-06" version="1">MRSTMVEKVDVAVIGGGPAGMTAASRIKRLKPELRVAVFERSGYVSYAPCGLPYYLGGLVDSLEHLVHYPVRVFTEERGIEVYTRTEVVEVGDGYLRARDASGERTYEWGKLLIATGARPKVPPVEGVDLEGVFTLRVLEDGEKARRYLEKATRVAVVGGGYIGLEVAENLVRAGKTVLLFEVLDHVFPAVDPDMALLVEKELARNGVELHLGEGLKGIHGRDRVESLETTKGEYKVDAVFIATGVAPETRLAEKLGVKKGSTGALSVDKSMRTNVDDVYAAGDVAEALNLVTGKNDWFPLAPVANKMGYVAGAAMAGLKAEFPGAVGTSITKVFGLEVGRAGLTTARAQQEGFDPVSVMINANSKASYYPGSSAMSVKLIADRRTGQLLGGQIIGGDGVLARLNSLAVLLSFRARVEDAFFSDLGYAPPFSPVWDPIVTAARVLLGKIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI5</accession>
    <name>A1RWI5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin/lipoyl attachment domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0155"/>
    <dbReference type="EnsemblBacteria" id="ABL77565">
        <property type="protein sequence ID" value="ABL77565"/>
        <property type="gene ID" value="Tpen_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0155"/>
    <dbReference type="eggNOG" id="arCOG02095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_5_2_2"/>
    <dbReference type="OMA" id="KRINRTY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="106" mass="11397" checksum="7168CD69BBDE00E3" modified="2007-02-06" version="1">MEVEVPEGETPLGTVLSVLQTSLVKKVEAQPQSKEYVVAPITGRVSRILVKEGQRVEKGTTIATMEAMKTLIEVKSSMNGVVKEVLVAEGEVVKQGAPIARIAPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK8</accession>
    <name>A1RWK8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751853.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0178"/>
    <dbReference type="EnsemblBacteria" id="ABL77588">
        <property type="protein sequence ID" value="ABL77588"/>
        <property type="gene ID" value="Tpen_0178"/>
    </dbReference>
    <dbReference type="GeneID" id="4600880"/>
    <dbReference type="KEGG" id="tpe:Tpen_0178"/>
    <dbReference type="eggNOG" id="arCOG01872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_2_2_2"/>
    <dbReference type="OMA" id="PVWPNGY"/>
    <dbReference type="OrthoDB" id="78708at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="208" mass="22477" checksum="759F65FD936B116E" modified="2007-02-06" version="1">MKLDIAILAGGSGKRLGGVYKPVVEVCGKPAVVLLAENLGEAASSLILVVHDSVQKRVLEDVLARYPVATRYRVLLDEVPVRAPLAGLYTALRNSRSEFLGVAPADTPFLRGSSLLKLRSLAEGYDGAVPVWPNGYVEPLIAVYRVPRVLTAVASALSSGRLRVMDALGKLNVRLIPIGEVFADPERETFNLNRPEDYEKARKLCGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL4</accession>
    <name>A1RWL4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="2">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751859.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0184"/>
    <dbReference type="EnsemblBacteria" id="ABL77594">
        <property type="protein sequence ID" value="ABL77594"/>
        <property type="gene ID" value="Tpen_0184"/>
    </dbReference>
    <dbReference type="GeneID" id="4600886"/>
    <dbReference type="KEGG" id="tpe:Tpen_0184"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_8_2_2"/>
    <dbReference type="OMA" id="FAWSTID"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proton_antipo_M" evidence="1">
        <location>
            <begin position="135"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="487" mass="52148" checksum="1AE22280AAE5CEC6" modified="2007-02-06" version="1">MISPVELFVIGLAAYLAAAVLALLFDSKPKLANVVSMASSAIASVAVACASAIVMETGKPVVLGPYRVVVAEAPLTVYIDSLSASFVFAVATLTFAISIFSVGYLKMFYGERSIGYFGTFYNAFIFSMIMTCCTDNVLWFLFFWELMTASSYFLVIYEDTPDVRRIGYLYFILMHVGFACIAVSLVLTVLTSGSWSLLKVDPHTIEPGVKTAILALALIGFGMKLGLVPLHVWLPEAHPAAPSNVSALLSGVMLSMGLYGLTRISLALQANMEWWYSAIAILAVLSVAVGVLCMPAQMDFKRLLAYSSIVEMGLASLSLSYYLAGSQLGLKAMLMHVVNQAYAKGALFALSGLLLYCAGTKRLSDIRGLWDANPLVAAVLLAAALDIMGLPPFGCFFSKAYIVLSGFNPALGLWAPLAASASLAIEVVCFAWFLRVVQHAVMGEPSEAMQKLRGKSPRAMLAGLLVLVLLCVVSGFVSLYLIGGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN9</accession>
    <name>A1RWN9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0209"/>
    <dbReference type="EnsemblBacteria" id="ABL77619">
        <property type="protein sequence ID" value="ABL77619"/>
        <property type="gene ID" value="Tpen_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0209"/>
    <dbReference type="eggNOG" id="arCOG01994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099320_0_1_2"/>
    <dbReference type="OMA" id="CAFGLKF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="176" mass="18805" checksum="952C9168157FB186" modified="2007-02-06" version="1">MVFFFSSGILVGAFLVYPVAGKSALGYLGSTPFDVRISPAALALLIFTNNVKVVLLIVLSALAVIGPPLIVFLNGVIVGAVSMYAVERTSIVTLLLSLTPHGVIEVPAILYVSARSYAFGISVWKEILHKSRGNTHTHALELVRALLVTIVLLFIAAVIEAFVTPRIAGIDYVFKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR7</accession>
    <name>RL18_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl18</name>
        <name type="ordered locus">Tpen_0237</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751912.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWR7"/>
    <dbReference type="SMR" id="A1RWR7"/>
    <dbReference type="STRING" id="368408.Tpen_0237"/>
    <dbReference type="EnsemblBacteria" id="ABL77647">
        <property type="protein sequence ID" value="ABL77647"/>
        <property type="gene ID" value="Tpen_0237"/>
    </dbReference>
    <dbReference type="GeneID" id="4600707"/>
    <dbReference type="KEGG" id="tpe:Tpen_0237"/>
    <dbReference type="eggNOG" id="arCOG04088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OMA" id="MAHGPRY"/>
    <dbReference type="OrthoDB" id="108717at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000053133" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="196" mass="21831" checksum="76150FBB84EE69CC" modified="2007-02-06" version="1">MARGARYRVPLKRRREGKTNYYKRRKLIISGKPRLVVRVLSRTAIVQIAKATPKGDVVIASAHSNELKKYGWKGYRRNTPALYLLGFLAAKKALKQGVTEAIVDIGLHRPVKASRVFAAVKGALDAGLKIPVGDGVLPEDDRVRGEHIANYAKMLKESNPELFKLRFSGYLSAGLDPESLPEHFDSVKQKIEEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU5</accession>
    <name>A1RWU5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751940.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0265"/>
    <dbReference type="EnsemblBacteria" id="ABL77675">
        <property type="protein sequence ID" value="ABL77675"/>
        <property type="gene ID" value="Tpen_0265"/>
    </dbReference>
    <dbReference type="GeneID" id="4601683"/>
    <dbReference type="KEGG" id="tpe:Tpen_0265"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_2_2"/>
    <dbReference type="OMA" id="YLFYENE"/>
    <dbReference type="OrthoDB" id="58376at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc6_C" evidence="4">
        <location>
            <begin position="320"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="437" mass="49713" checksum="612BB89BE01519C1" modified="2007-02-06" version="1">MSFSYDGYARPRRIILDERKLSSEYVPLKLPHRAEQIAETLRVMQDVIRGQKDVLRTIIYAGQAGTGKTAVARTIGREVKDKAAKGKIPPILVSYVNAQEYRTKFQVFRKIGSDCGLDIPRRGFSSQELAEYVFGFISRRENNALIILDEADILAKQKDGNELFYVFSRVREVLPEVQLGLGLIVIFRQLDESLAYLDKAVVSSLSGRVVRFNPYTSQQLQDILWARIRDEGAIREEAVSEEIIEMIADTVGYNPDTKSGIGDARMAIKVLYYSALRAEGEERETILPEDVRYVVNQGVLPSYIDEETVTRLPLHEKLLLLAITELLLLEREKAYVNMGEVVIQYEDVCNKFGEKPLRYTRIWEKVQFLKKMGLVDTRTGRGETRGRTTMITFPGLPANSVVGINRIPLDLLEKILRDSIEKELSSRGEERGEELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV0</accession>
    <name>A1RWV0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH iclR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751945.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0270"/>
    <dbReference type="EnsemblBacteria" id="ABL77680">
        <property type="protein sequence ID" value="ABL77680"/>
        <property type="gene ID" value="Tpen_0270"/>
    </dbReference>
    <dbReference type="GeneID" id="4601891"/>
    <dbReference type="KEGG" id="tpe:Tpen_0270"/>
    <dbReference type="eggNOG" id="arCOG02756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1965676_0_0_2"/>
    <dbReference type="OrthoDB" id="141461at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="127" mass="14736" checksum="C931DFC02FDD7DD7" modified="2007-02-06" version="1">MTIKIVVERLPTREDMDPVTLRRHPALRQLYSLYEEEGEVAPKIIRENLSVEAARKVLSNRVIELLSAIKENKGASISELARILRRSPSNVYRDLAELARWRIIKLREDGRKKVPEIIAKKIEIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX1</accession>
    <name>A1RWX1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751966.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0291"/>
    <dbReference type="EnsemblBacteria" id="ABL77701">
        <property type="protein sequence ID" value="ABL77701"/>
        <property type="gene ID" value="Tpen_0291"/>
    </dbReference>
    <dbReference type="GeneID" id="4601300"/>
    <dbReference type="KEGG" id="tpe:Tpen_0291"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="QTGSNDM"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="545" mass="59471" checksum="FCB6F28B43CE28C7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX03</accession>
    <name>A1RX03_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751998.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0324"/>
    <dbReference type="EnsemblBacteria" id="ABL77733">
        <property type="protein sequence ID" value="ABL77733"/>
        <property type="gene ID" value="Tpen_0324"/>
    </dbReference>
    <dbReference type="GeneID" id="4600975"/>
    <dbReference type="KEGG" id="tpe:Tpen_0324"/>
    <dbReference type="eggNOG" id="arCOG00398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117042_0_0_2"/>
    <dbReference type="OMA" id="ADFPYEG"/>
    <dbReference type="OrthoDB" id="112460at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="23297" checksum="564D5BF168595A7F" modified="2007-02-06" version="1">MREKHLLFSRQYLEKLLSNEKTTTIRVKRPRLKPGDEVLVHCGGRVLGRAKITYIYKKKLRDLTLDEAVRDGFGSLEELIRNLKRHYPRLSADSYVYVINFSWVERFEEPPSDVDVSWPYAASFREVAEKALNTLELDEFERNVLKLVVSEGSIRKAAYALGGLNQRFIVRDVLRRVAQRLEEMGVLARVNTSARSPLDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX25</accession>
    <name>A1RX25_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48, Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0346"/>
    <dbReference type="EnsemblBacteria" id="ABL77755">
        <property type="protein sequence ID" value="ABL77755"/>
        <property type="gene ID" value="Tpen_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0346"/>
    <dbReference type="eggNOG" id="arCOG01333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625032_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="272"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="438" mass="48682" checksum="C1AAFF065214E7D2" modified="2007-02-06" version="1">MTADKKREVFLPPACLETPGLLRSLVEGFFEKNGFSKEPISGSVVVFRSSTKDVVVTCKFYSYKVELLSSHKEMEKISRKVYGYLFSNCVAEPEVAFIVPLDRSGNPVSIYFESWENVHPAPSIDTVAAVFPLLSFFSVYLIGVRLLEALLLSPLLSILALLLVRLWLRIRAVRVDEGSVVVVKAKIRQVGTTSENVYFAKLDLISSLRRKEGLSKERVANVLHYWGILTRDVELKTYDFRSIFEKLKLRKPPSIFLLDDKRRTALSLGLPPAIALTPALLVDLSEEELASVLVHEAAHIRHRDALRALLLITSGLALGALIYLFSYSIELLALYAVASYILTSMLLKSLEIRADLEAAEAFPEAYRKVLVKLEYPRLVKPTSMLGIVASILNVFSYPPPTVRLKIIEEGCSGKGAVAVAKCLLRCYLCGGGVEGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX30</accession>
    <name>A1RX30_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752025.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0351"/>
    <dbReference type="EnsemblBacteria" id="ABL77760">
        <property type="protein sequence ID" value="ABL77760"/>
        <property type="gene ID" value="Tpen_0351"/>
    </dbReference>
    <dbReference type="GeneID" id="4600889"/>
    <dbReference type="KEGG" id="tpe:Tpen_0351"/>
    <dbReference type="eggNOG" id="arCOG06065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2420206_0_0_2"/>
    <dbReference type="OrthoDB" id="124024at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="91" mass="10400" checksum="1CC69442112334C7" modified="2007-02-06" version="1">MPGVSVEKILEWARNTNSTVEFFFENSPYRIRIDKLIRAVDPSGNIVPWTRAFGVKKPADVLATFHVKKIVVKKEGEEKELRSLEELSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX48</accession>
    <name>A1RX48_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752043.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0369"/>
    <dbReference type="EnsemblBacteria" id="ABL77778">
        <property type="protein sequence ID" value="ABL77778"/>
        <property type="gene ID" value="Tpen_0369"/>
    </dbReference>
    <dbReference type="GeneID" id="4600769"/>
    <dbReference type="KEGG" id="tpe:Tpen_0369"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_2_2"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="OrthoDB" id="102399at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="187" mass="20856" checksum="9EC6C853FEB6EF0A" modified="2007-02-06" version="1">MTNLIRSFVAVKVSSPSVLQRVEALQSDLRDAGLSAKFVEKENLHITLRFLGEIPPHTLEEVRNRLAKLSYHRFKIVLKGVGGFPSLDRPRVLWIGVDEGSRELSELAELVRTSLKGVKLPEPDEEFHPHLTIARLKGPLSAGARRIIAGSADTVFGEQEVTSFSLYKSTLTPRGPIYDEIARYDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX81</accession>
    <name>A1RX81_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752076.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77811">
        <property type="protein sequence ID" value="ABL77811"/>
        <property type="gene ID" value="Tpen_0402"/>
    </dbReference>
    <dbReference type="GeneID" id="4602118"/>
    <dbReference type="KEGG" id="tpe:Tpen_0402"/>
    <dbReference type="eggNOG" id="arCOG14831">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381485_0_0_2"/>
    <dbReference type="OrthoDB" id="124550at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="194" mass="21344" checksum="BEC0222AD164C80D" modified="2007-02-06" version="1">MVDKATLRKRFLRNLRLAGLNREDEILAVTLPNLQSKVALELLLSVEEEFPVVIRHLHVGAELPGEIGLLARKTVGSETFAERAPSTYTELKVLVARLAKPGQVVVLPMVAEEVAAYFLEEVLRGNLAGLSLEASNRTAYPLATTTLEEIRRVAGPSSLRPQCIASSNLLSILEKSVDPRAAAKFYVENYARPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX99</accession>
    <name>RL37_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl37e</name>
        <name type="ordered locus">Tpen_0420</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX99"/>
    <dbReference type="SMR" id="A1RX99"/>
    <dbReference type="STRING" id="368408.Tpen_0420"/>
    <dbReference type="EnsemblBacteria" id="ABL77829">
        <property type="protein sequence ID" value="ABL77829"/>
        <property type="gene ID" value="Tpen_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0420"/>
    <dbReference type="eggNOG" id="arCOG04126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OMA" id="RIRRYSW"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_L37e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000061081" description="50S ribosomal protein L37e">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <sequence length="63" mass="7435" checksum="B6B122E919A36973" modified="2007-02-06" version="1">MVKGTTSFGKRGRNITHIRCRRCGHHSFNVRKGYCAHCGFGRSKRIRRYSWQNKKAVTRIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA2</accession>
    <name>A1RXA2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77832">
        <property type="protein sequence ID" value="ABL77832"/>
        <property type="gene ID" value="Tpen_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0423"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="482" mass="54507" checksum="B04531A51DCFBCC2" modified="2007-02-06" version="1">MGRGMTGGEEGEEVVRELVYERAAQSLYATRTEDKRRSRGKKKRGEIHYVGLFDAVTGINWDFTRFAAHALTVVPDEVYPRFYRFIDIDARKYLLLGDDEKPREGSAAMELRNRLQAIVDATEDGLRAEKKGKVWRVYVPHENWYVTVSRPSTHSWSIHVPLEGFWTEASFPEVLARTSPDVLRSLQRGWLLTDVTPPHGRNSDVNFSTTQPWQLPATLANFPGEVRLGVTAGVLGSTRASIKWKAYVHGYAEELGWASELIGEAKRAEYRRLVDECRALRGDSVALLTAFLGDGMLAFFLRLRMLFFRIGNETLYLPAKSAIVNVRLAVERASEYVRFVSLVTKNPKIRHFLFVGFGLPQKRGKKGGQRNSPFYANIAGARLLLAYVSSTNNIYARIVVDAVPQGWYEHALEEGWDVRIVASGTSSGGKEYYQVTQSSLFEHARYDAALRETLLAFAKAKAEQYPKAWELVERLEKLGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE8</accession>
    <name>A1RXE8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752143.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0469"/>
    <dbReference type="EnsemblBacteria" id="ABL77878">
        <property type="protein sequence ID" value="ABL77878"/>
        <property type="gene ID" value="Tpen_0469"/>
    </dbReference>
    <dbReference type="GeneID" id="4602028"/>
    <dbReference type="KEGG" id="tpe:Tpen_0469"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="69" mass="7732" checksum="B36B1B06976FF0A1" modified="2007-02-06" version="1">MRTIGALSRLLASTLRRDGLYEARLVEALDAIEEFLTSVRGATPQVEEDEELERELKGCVEELRELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF2</accession>
    <name>A1RXF2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="6" type="ordered locus">Tpen_0473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0473"/>
    <dbReference type="EnsemblBacteria" id="ABL77882">
        <property type="protein sequence ID" value="ABL77882"/>
        <property type="gene ID" value="Tpen_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0473"/>
    <dbReference type="eggNOG" id="arCOG04473">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_3_1_2"/>
    <dbReference type="OMA" id="MEERIYT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="103" mass="11971" checksum="1FE5F4A66E9BB90A" modified="2007-02-06" version="1">MPGKMADGEYTRTYVINLRRVYSAPRKKRAKVAVRAIRDFIARHLRFPDRIKISPELNLIVWSRSIEKPPRKVKVDVSFKVEDGRVTEVEVLPHGAKEQKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG9</accession>
    <name>A1RXG9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethyladenosine transferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752164.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0492"/>
    <dbReference type="EnsemblBacteria" id="ABL77899">
        <property type="protein sequence ID" value="ABL77899"/>
        <property type="gene ID" value="Tpen_0492"/>
    </dbReference>
    <dbReference type="GeneID" id="4601790"/>
    <dbReference type="KEGG" id="tpe:Tpen_0492"/>
    <dbReference type="eggNOG" id="arCOG04131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_2"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="109936at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="270" mass="30466" checksum="BE01E36B30ACE4D8" modified="2007-02-06" version="1">MLSAYVREALRSIRYKRRLGQHFLVDDTVASRIASFVNGEDVYEVGCGLGSLTLPLSERSAYVFCCEKDEALALFLSRELYRRGIGNVDIMVGDALRIDLSRSSHLVVSNTPFNISSQLVVKLCYDEGLLKAYLGLQREVAERLYAKPGTREYGRLSVISQLCFSIERLFDVPPNAFLPPPKVFTSFVRLVPLRRLGAEDVRLVEEFSRRIFPYINRVVTTALRIGLGVNREVAEDLVRESNVLGSRRVREINPEEVLALARQARAKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ8</accession>
    <name>A1RXJ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0522"/>
    <dbReference type="EnsemblBacteria" id="ABL77928">
        <property type="protein sequence ID" value="ABL77928"/>
        <property type="gene ID" value="Tpen_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0522"/>
    <dbReference type="eggNOG" id="arCOG00908">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112764_0_0_2"/>
    <dbReference type="OMA" id="THVYVQL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019202">
        <property type="entry name" value="DUF2067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09840">
        <property type="entry name" value="DUF2067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="211" mass="23443" checksum="4D6AEB35264C39F9" modified="2007-02-06" version="1">MRGVTLTFTFNDSGEAVSFLSMLKKELGDARLYGEIKGKKLKVFIPEGERTDDIVRRVKTLYREIHEKTLTVRPRKLGVSTILSMANLEVAIPVPALADVLNMVGKKAVLRGEYLETNASLKEAVEFAEKLSRAYKSLLHEPLTATARRLAAVASVVLGTEPDKAVDLLVSKGILKQVEGNVSLSEEYTKSLSRLRSLLEERRDDVRETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM0</accession>
    <name>A1RXM0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752215.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0544"/>
    <dbReference type="EnsemblBacteria" id="ABL77950">
        <property type="protein sequence ID" value="ABL77950"/>
        <property type="gene ID" value="Tpen_0544"/>
    </dbReference>
    <dbReference type="GeneID" id="4600501"/>
    <dbReference type="KEGG" id="tpe:Tpen_0544"/>
    <dbReference type="eggNOG" id="arCOG04351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498427_0_0_2"/>
    <dbReference type="OMA" id="PSTHDFN"/>
    <dbReference type="OrthoDB" id="92621at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="12"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="544" mass="59675" checksum="53716F328183777A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP0</accession>
    <name>A1RXP0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ordered locus">Tpen_0564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0564"/>
    <dbReference type="EnsemblBacteria" id="ABL77970">
        <property type="protein sequence ID" value="ABL77970"/>
        <property type="gene ID" value="Tpen_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0564"/>
    <dbReference type="eggNOG" id="arCOG00487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_2"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="518"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="635" mass="71129" checksum="D8C4692F4626F62A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR1</accession>
    <name>A1RXR1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752256.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0586"/>
    <dbReference type="EnsemblBacteria" id="ABL77991">
        <property type="protein sequence ID" value="ABL77991"/>
        <property type="gene ID" value="Tpen_0586"/>
    </dbReference>
    <dbReference type="GeneID" id="4600627"/>
    <dbReference type="KEGG" id="tpe:Tpen_0586"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OMA" id="DMLGIIN"/>
    <dbReference type="OrthoDB" id="58376at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="53"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="396" mass="44084" checksum="17696172BA452B39" modified="2007-02-06" version="1">MSLEEIFDQYLGSRIYKAREKLLPDYVPEDLPHRDEQIKRLALTLAPALSGSRPSNVFIYGLTGTGKTAVTKYVLRRLAEKGGGRIEYVYINCRQNNTSYRVLAELGKFLGVKIPFTGLALGEVMKRITQALDRKHRILIVVLDEVDNLVKRNGDDVLYYLTRVNEQLTNTRVSVIGITNDLKFTEFLDARVKSSLGEEELVFPPYNAIQLEDILRRRAKEAFHEGVVSDAVIKKVAAIAARQNGDCRLALDILLKAADIAERERASEVTEAHVDKARNEIEKNLTVDVIKTMPLHVKLVLASIYLLTKEGGAKTITTGLIYDKYKELVTKVGIEPVTSRRITDILNELDMAGIINARVISLGRYGRTKVVALGVPLKNVEEGLLSDIVISAVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR7</accession>
    <name>A1RXR7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel-dependent hydrogenase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752262.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0592"/>
    <dbReference type="EnsemblBacteria" id="ABL77997">
        <property type="protein sequence ID" value="ABL77997"/>
        <property type="gene ID" value="Tpen_0592"/>
    </dbReference>
    <dbReference type="GeneID" id="4600634"/>
    <dbReference type="KEGG" id="tpe:Tpen_0592"/>
    <dbReference type="eggNOG" id="arCOG01550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030087_0_0_2"/>
    <dbReference type="OMA" id="EEVTHSW"/>
    <dbReference type="OrthoDB" id="32760at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="596" mass="66614" checksum="12A997450DCE60B3" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR8</accession>
    <name>A1RXR8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752263.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0593"/>
    <dbReference type="EnsemblBacteria" id="ABL77998">
        <property type="protein sequence ID" value="ABL77998"/>
        <property type="gene ID" value="Tpen_0593"/>
    </dbReference>
    <dbReference type="GeneID" id="4601233"/>
    <dbReference type="KEGG" id="tpe:Tpen_0593"/>
    <dbReference type="eggNOG" id="arCOG06072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080177_0_0_2"/>
    <dbReference type="OMA" id="YGKLHEW"/>
    <dbReference type="OrthoDB" id="78549at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="263" mass="29829" checksum="12948B4B12DA58F9" modified="2007-02-06" version="1">MDLLDLAIYVLPPYVVATLAFGVAYRLSRYLFLWKRGYSAPRRARPIGKLLVGLVVTFLDPLVQAAKKRKSDFVGGLIALHILGVIPLIFLLSQHVAMFSYWIPLYSLLKPFAIPSSITSASQYFFANVLPASEMGWVFTNSVWGPLTLILNGDLLAILAIIGVSYKLGDKLVRLYHRLRHVRAGDFFDLALLLSILVTGFLATHHLPSPDVTTYRFMLGLHILLAELLVALLPFTKFWHFVFGYWYGKLHEWYELKFNRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX2</accession>
    <name>A1RXX2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sjogrens syndrome scleroderma autoantigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0650"/>
    <dbReference type="EnsemblBacteria" id="ABL78052">
        <property type="protein sequence ID" value="ABL78052"/>
        <property type="gene ID" value="Tpen_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0650"/>
    <dbReference type="eggNOG" id="arCOG00578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142653_1_0_2"/>
    <dbReference type="OMA" id="RLKISIM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="117" mass="12845" checksum="3FC509D712DE9D8F" modified="2007-02-06" version="1">MANLLKSGATMLETLCPTCRVPLFRLKSGEVVCPKCGQRYVIVASEEEEHRVKVDLVLLGLEQVTVQKISSLSASLASSETFDEITEVSRAIITLLQVLQLSRQIRGSEKGVQEKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY17</accession>
    <name>Y695_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein Tpen_0695</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0695</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752362.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY17"/>
    <dbReference type="SMR" id="A1RY17"/>
    <dbReference type="STRING" id="368408.Tpen_0695"/>
    <dbReference type="EnsemblBacteria" id="ABL78097">
        <property type="protein sequence ID" value="ABL78097"/>
        <property type="gene ID" value="Tpen_0695"/>
    </dbReference>
    <dbReference type="GeneID" id="4602010"/>
    <dbReference type="KEGG" id="tpe:Tpen_0695"/>
    <dbReference type="eggNOG" id="arCOG01043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134829_1_0_2"/>
    <dbReference type="OrthoDB" id="106305at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065156" description="UPF0201 protein Tpen_0695">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <sequence length="154" mass="17214" checksum="9C6540C67FD99704" modified="2007-02-06" version="1">MKVVVRAPFYPTESLEKVLSSIFNLFDAPKESCAVVGEGKGRYIECVFHNHKPLEKFRRLLRQQRILDAARSYVERGLREGEVKFYLNKQAAFAGKVSFCTYEAGESPLGSIIVVIELGKCSPDEFLNWLAPRTVNGKPVGEVSELKCLEQGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY18</accession>
    <name>A1RY18_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="11" type="ordered locus">Tpen_0696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0696"/>
    <dbReference type="EnsemblBacteria" id="ABL78098">
        <property type="protein sequence ID" value="ABL78098"/>
        <property type="gene ID" value="Tpen_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0696"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_2"/>
    <dbReference type="OMA" id="IWLTHIS"/>
    <dbReference type="OrthoDB" id="111803at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="316" mass="35163" checksum="02E8EBB1D863B98B" modified="2007-02-06" version="1">MNISSIRIMFWGTGGAVTPKSAEQPCIAVKMADTVFLLDVGERCQKALECFHLGVNSPLYIFVTHLHSDHYSGLIPLLETLSLLGRERALSVYGPPGLGSVVTGRRTTGYPVSLTELYGWEGILRFPGLPLTVSYVAAPHSYGALSYIIRVEDKVKLDEEKLEQEKIPPALRKELLEKGKVRVGSKEYSLNSFVKQVVRGVKISYTGDSLPSHRFASKAMESDVLIHDSTLLKRDWYRKPYMAHSTVEDAVAVFKATRSRLLVLTHFSAMYRNPAVDLSEAVGEYPRVLIAEKGLTIDVAFTEPRVFSVRINTDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY24</accession>
    <name>A1RY24_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0702"/>
    <dbReference type="EnsemblBacteria" id="ABL78104">
        <property type="protein sequence ID" value="ABL78104"/>
        <property type="gene ID" value="Tpen_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0702"/>
    <dbReference type="eggNOG" id="arCOG04181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062565_0_0_2"/>
    <dbReference type="OMA" id="YGVPLYA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="363" mass="39671" checksum="51F3AECE98E8153D" modified="2007-02-06" version="1">MDGDTLSFIMWLVALAIFSYITQEMQILKAISEVEGYVALFRGIRDKAVKVLVDQFSKYTASSEGASRDVLEQRILSLIETRIILPVDLDPYGIVRKIKHVLRTSEVELEKEVSRIAKGASRTEVQRLSSLVEVARELNLVYKLVNHYYLIARKFKSLWLVLQLNAQMPFVLEEVKAIEGALESFSKGIPVGDSAGPLVAALLARKYKGSFVEPVKDTEISQVTVDGKKVFIVKAKGPGSTTGHLEEALSWIFSREKVSLIVSVDAALKLEGEESGSVASGYGVAMGGIGVERFEIEELSTKHGVPLFAVLIKMSEAEALSVMTEKVYQGVQQAVRIVEDIISRAPEGSSIVVLGVGNSLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY88</accession>
    <name>A1RY88_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752433.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0766"/>
    <dbReference type="EnsemblBacteria" id="ABL78168">
        <property type="protein sequence ID" value="ABL78168"/>
        <property type="gene ID" value="Tpen_0766"/>
    </dbReference>
    <dbReference type="GeneID" id="4601088"/>
    <dbReference type="KEGG" id="tpe:Tpen_0766"/>
    <dbReference type="eggNOG" id="arCOG01285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_2_2"/>
    <dbReference type="OMA" id="IYYGTKF"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="15558" checksum="BC6EBC87A9F9A19A" modified="2007-02-06" version="1">MAYMRSVPRAWRERKIKYQLIGGKCKDCGKSFYPYRQVCPACGSENVEEVKLPERGVVEVFTVVRSPPSDFAWQAPYVVALVRLEDGTLVPAQITDVDPDEVHEGMEVEAVFRKYREQGQQGIIEYGIKFRPRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB6</accession>
    <name>A1RYB6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0273 protein Tpen_0794</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0273 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752461.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0794"/>
    <dbReference type="EnsemblBacteria" id="ABL78196">
        <property type="protein sequence ID" value="ABL78196"/>
        <property type="gene ID" value="Tpen_0794"/>
    </dbReference>
    <dbReference type="GeneID" id="4601255"/>
    <dbReference type="KEGG" id="tpe:Tpen_0794"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="OMA" id="FSQQFLW"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01076">
        <property type="entry name" value="UPF0273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022475">
        <property type="entry name" value="UPF0273_KaiC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03877">
        <property type="entry name" value="thermo_KaiC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="250" mass="27566" checksum="7466046F1CD16331" modified="2007-02-06" version="1">MSVIEKVKTGIPGFDELLYGGIPKRNIVLLSGGPGTGKTIFSQQYLFYGLQNNEPGVLVALEEHPVQIRRNMASFGWDVRKYEESGQFAIVDAFTGGIGEAAKRERYVVTSVDDVGELVDVVKAAIRDVKAERAVIDSVSTLYMTKPAMARSILMQLKRVLSGLGATSIFVSQVSVTERGFGGPGVEHAADGIVRLDLDEVNGELVRSLIVWKMRGTKHDMKRRPFEITDKGIVVYPDKVIRIGREYYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG8</accession>
    <name>A1RYG8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase small</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0847"/>
    <dbReference type="EnsemblBacteria" id="ABL78248">
        <property type="protein sequence ID" value="ABL78248"/>
        <property type="gene ID" value="Tpen_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0847"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114822_0_0_2"/>
    <dbReference type="OMA" id="AWDAGHD"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="207" mass="22064" checksum="DD55444C4BC1B75E" modified="2007-02-06" version="1">MLLTFLLLMLRLYMRLHAQFARFLGLTLLVPPGCFTPIGTYSTWLVSRVLEASPSAEVAVEVGTGVGTLALLAAKRGAYAVGVEVSEPCLRAAKANARRNSLDGLLDFVLCDAGSCLRSSSAGLVFTNPPYLPVDSEKPEDVPVAGGSDLSIFKKMLVNAVRIAKPGAPVVYSASNLTGLSIGKILLCARTPIDEVCAYLVVRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL1</accession>
    <name>A1RYL1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ordered locus">Tpen_0890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752556.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0890"/>
    <dbReference type="EnsemblBacteria" id="ABL78291">
        <property type="protein sequence ID" value="ABL78291"/>
        <property type="gene ID" value="Tpen_0890"/>
    </dbReference>
    <dbReference type="GeneID" id="4600466"/>
    <dbReference type="KEGG" id="tpe:Tpen_0890"/>
    <dbReference type="eggNOG" id="arCOG01432">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_2"/>
    <dbReference type="OMA" id="MLHQTII"/>
    <dbReference type="OrthoDB" id="24741at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="76"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABL78291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="460" mass="51159" checksum="D5B3C2559AC2EF4C" modified="2007-02-06" version="1">MSKKYFLDEEELPREWYNILPDLPEPLPPPLNPATGKPVSPEDLEPIFPKELIRQEVSQERFIPIPEEVLEVYRIWRPTPLIRATRLEKALRTPARIYYKYEGVSPPGSHKPNTAVAQAYYNAREGVARLTTETGAGQWGSALSFATMLFGLKLTVYMVRVSYQQKPYRAILMQTWGAEVVPSPSNRTKAGRAFLEKDPEHPGSLGIAISEALEDAIEHEDTKYSLGSVLNHVLLHQTIIGLEAIKQMQALDEFPDIVIGCVGGGSNFAGISYPFYYLVRSGKAPKKTRFLAVEPASCPSMTKGEYMYDFGDTARLTPLLKMYTLGHDFVPPPIHAGGLRYHGAAPTLSLLKKAGIFESVAYNQVEVFEAARLFARTEGIVPAPESAHAIKAVIDEALEAKRKGEEKVILFNLSGHGLLDLAAYREFLEGRLPAHEYPAEAIQKSIAKIKEYLLARGIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM7</accession>
    <name>A1RYM7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752572.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0906"/>
    <dbReference type="EnsemblBacteria" id="ABL78307">
        <property type="protein sequence ID" value="ABL78307"/>
        <property type="gene ID" value="Tpen_0906"/>
    </dbReference>
    <dbReference type="GeneID" id="4602119"/>
    <dbReference type="KEGG" id="tpe:Tpen_0906"/>
    <dbReference type="eggNOG" id="arCOG01799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_2"/>
    <dbReference type="OMA" id="IFATYSI"/>
    <dbReference type="OrthoDB" id="56199at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPe" evidence="3">
        <location>
            <begin position="53"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="53"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="30639" checksum="EF5286EA93F2990C" modified="2007-02-06" version="1">MSIDKKTLGSIAKFLAVFAVGLLLGTSLGYFLWHSASTTQTVSYVDKIKARGKLIVGTSADWPPFEYVDKNGNYAGIDIEIAKRIAQELGVQLEIKDMKFAALIEALKNGDVDIVIADMTPTAEREKVVDFSIPYYTSKGYAVITTAKSDIKSEQDLYGKKIGVQLGTIQEDWANNNLKGKAEIKSYDRVYPEMVWALQRGDIDAMIVGDKIAEALITKEPSLKIATYVSIPTIGGAVAVPQGAEDLKYVVNSVIEKLLESGEMNKIFQQEILKWLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM9</accession>
    <name>A1RYM9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752574.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0908"/>
    <dbReference type="EnsemblBacteria" id="ABL78309">
        <property type="protein sequence ID" value="ABL78309"/>
        <property type="gene ID" value="Tpen_0908"/>
    </dbReference>
    <dbReference type="GeneID" id="4602121"/>
    <dbReference type="KEGG" id="tpe:Tpen_0908"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_2"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="32313at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="291" mass="31023" checksum="E371CF1657ADB90A" modified="2007-02-06" version="1">MSAEKERQLKLEALKKAREQEEVARQRLSQVKFKVAVLSGKGGVGKSLVTANLAAALAKKGFEVGVLDADVHGPSIPKMFGVHGQVLYAGPGGIMPVVGVGNVKIVSADLMVPEEDTPLIWRGPLKTSFLRELLSMVAWGPLDFLLVDLPPGTGDEPLTIAQLIRDLSGAIVVTTPSDLTRIVVKKAITFCKQVKMPLLGVVKNMAYFVCPVCGTKHYIFGKSGAERLSEEMNVRVLAEIPLDPRINESADNGVPFVLAYPDSEAAKSFYKLADEVLAALKASSSSGGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP1</accession>
    <name>A1RYP1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0920"/>
    <dbReference type="EnsemblBacteria" id="ABL78321">
        <property type="protein sequence ID" value="ABL78321"/>
        <property type="gene ID" value="Tpen_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0920"/>
    <dbReference type="eggNOG" id="arCOG03926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640060_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="161" mass="17320" checksum="8F495071C87C450D" modified="2007-02-06" version="1">MIGTVTLLQVAIIILAAFSFLLFLNQMQSQNVMLSEVAESAAREVVELISVYTLGGSNLSYMYLTVPDTLAGQPYSLSIGETSENVLNVTARLQIYQQVRVVVTPNFGQSPVHAVKGSREVGGLTVSDTILLPLPPGYKPAIVAFRDGNSIYVGFAKIQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS7</accession>
    <name>A1RYS7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752622.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0957"/>
    <dbReference type="EnsemblBacteria" id="ABL78357">
        <property type="protein sequence ID" value="ABL78357"/>
        <property type="gene ID" value="Tpen_0957"/>
    </dbReference>
    <dbReference type="GeneID" id="4600761"/>
    <dbReference type="KEGG" id="tpe:Tpen_0957"/>
    <dbReference type="eggNOG" id="arCOG05631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115255_0_0_2"/>
    <dbReference type="OMA" id="TYPDRIC"/>
    <dbReference type="OrthoDB" id="94129at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="205" mass="23056" checksum="EB692889141FE3AB" modified="2007-02-06" version="1">MSISRASLEEEVYLRGLTGFLVGEKLYEGFKRIAFVTFADRICCSIVAAQIAGYMHRYGYGSGSFKVFFYEEGREDELARQVESFKPDAVSLMMGGEQKMSRVASATREVLKAFSRRGLRVPVIFHVRVFLATKQLSSLLADEEVSSYLGSLPELRVFTADLGAKKFFFNRISLEGGKLALRKFAESDLTEEHVDLLKRSLPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU1</accession>
    <name>A1RYU1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0971"/>
    <dbReference type="EnsemblBacteria" id="ABL78371">
        <property type="protein sequence ID" value="ABL78371"/>
        <property type="gene ID" value="Tpen_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0971"/>
    <dbReference type="eggNOG" id="arCOG01426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_2_1_2"/>
    <dbReference type="OMA" id="WLIESMK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="206" mass="23669" checksum="190C7D4109FA13BF" modified="2007-02-06" version="1">MAAQLKRELFRLLKEDEEFRYAMMALLGLEDLRGSMREVRDSVVELRRSVEELRKTVEEHTKQIIELRRETEGLDERVSRVEGLLERLAVSEEEEANDVIMHLLRQRGLAVETAPAVFDEKHEFDIYGTDGRVTVVGEAKVRAGPSTVRRLAERVEGAVERWPEKFPGTVVKVLYCLRASPGAVEEAERLGVWLIESMKERAQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX3</accession>
    <name>A1RYX3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPases involved in chromosome partitioning-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1003"/>
    <dbReference type="EnsemblBacteria" id="ABL78403">
        <property type="protein sequence ID" value="ABL78403"/>
        <property type="gene ID" value="Tpen_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1003"/>
    <dbReference type="eggNOG" id="arCOG00599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884551_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="304" mass="33822" checksum="02B3BAA217442EFE" modified="2007-02-06" version="1">MSTAKQSRTLAFISASGGVGKTTLSVLFAAYLQHVKGVPAREILLVDLDPTAGLSLLLLGDENYAKAEDEGKTLSAAYEDLFERGRRVEPERYIWEASFKDSYFKVLVPGESFPRVVEELWRPGNPGESFRRLLEELGVYSSFRYVVVDSAPFFDERYTVLSLYSSDKYAVVLRPSIVDFRRTLRMIRYLAQHHSGRLGGSTGAFYSKILAVYNLVDTGTREASALAERGIRNPEGKEEGKAKPSQEVLKGIDSLSTLVGRVADYYVPAHSDIARLDVIGKLKKKKEKAELSPVLKQLADWAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ5</accession>
    <name>A1RYZ5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1025"/>
    <dbReference type="EnsemblBacteria" id="ABL78425">
        <property type="protein sequence ID" value="ABL78425"/>
        <property type="gene ID" value="Tpen_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1025"/>
    <dbReference type="eggNOG" id="arCOG14940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933372_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="15095" checksum="BA84C28B3D199BBC" modified="2007-02-06" version="1">METNLYLFFPRILVDEFTRIVMWVNRIGSSEVLATEISRNTKKAKEVISLLSKYGLVRESRKGRLRIVSLSPKGLEVYRYLEMAKRVVYGEGPAGEPVEEAEPEVAGAELPSFARDNPWLKVLAEKVRPRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ03</accession>
    <name>A1RZ03_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752698.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1033"/>
    <dbReference type="EnsemblBacteria" id="ABL78433">
        <property type="protein sequence ID" value="ABL78433"/>
        <property type="gene ID" value="Tpen_1033"/>
    </dbReference>
    <dbReference type="GeneID" id="4600938"/>
    <dbReference type="KEGG" id="tpe:Tpen_1033"/>
    <dbReference type="eggNOG" id="arCOG03776">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985606_0_0_2"/>
    <dbReference type="OMA" id="DVEWKAR"/>
    <dbReference type="OrthoDB" id="83928at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="292" mass="31731" checksum="BF3EE9A95BB75AB3" modified="2007-02-06" version="1">MTLCPYCGANVERNPGEVVLTCPYCGTAFTVEGGEVGEHLMGRINYSVQQVFENFKSWALRMPETPNDFLEKALFKSYEVRFYPFWVFVFQARVSYAGGYEDLTLPVHVPGHTSMLGTPLEKLRPTLGGKVFYSHRYVVNAGAKLVNPDVGPEDAEKKAVEQAGEMALESLSIRFGGRARLRVESLAVSERKLVHHPVIHATYTYSGREYKFMADASDSRILYAEIPVEAKFRAAAAAGGLASLGLALASLLAARDAPMFAATSLLGFLVVAGVSLSKAFAPTAVVTKSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ07</accession>
    <name>A1RZ07_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752702.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1037"/>
    <dbReference type="EnsemblBacteria" id="ABL78437">
        <property type="protein sequence ID" value="ABL78437"/>
        <property type="gene ID" value="Tpen_1037"/>
    </dbReference>
    <dbReference type="GeneID" id="4600942"/>
    <dbReference type="KEGG" id="tpe:Tpen_1037"/>
    <dbReference type="eggNOG" id="arCOG15085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2505136_0_0_2"/>
    <dbReference type="OrthoDB" id="127690at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="9498" checksum="3D9BC663F1E3CDEF" modified="2007-02-06" version="1">MCLVKSRSLVCASSKTYLLAVEEGCLGRVAEWLERAGKVTARYGPLVKGVYKDAIITLLEPDKVQVILQFSKLSIEEIEEEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ09</accession>
    <name>A1RZ09_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1039"/>
    <dbReference type="EnsemblBacteria" id="ABL78439">
        <property type="protein sequence ID" value="ABL78439"/>
        <property type="gene ID" value="Tpen_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1039"/>
    <dbReference type="HOGENOM" id="CLU_1248341_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="212" mass="22927" checksum="1535F401D34BCD8F" modified="2007-02-06" version="1">MKASRLLAALAALLAVVLVVAVLQTGESPEKVIVDARNRLLGSKGWVFEERVNFTKGWVRVLVSGTVDLGSHTLNTTVVVLRGSQPSLSVIYSNRSVTLVNLGGGWARAGEGWRVNDTVIYRLLELARASPEKHLKPSAKGFTVFFGGGCTDTCTGLYQYLLRLAGLEGSNPTSYKGVLTVEEGYPRAVYVEFYEGGEATCSLLYSLRPLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ17</accession>
    <name>A1RZ17_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-vinyl reductase, 4VR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752712.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78447">
        <property type="protein sequence ID" value="ABL78447"/>
        <property type="gene ID" value="Tpen_1047"/>
    </dbReference>
    <dbReference type="GeneID" id="4600790"/>
    <dbReference type="KEGG" id="tpe:Tpen_1047"/>
    <dbReference type="eggNOG" id="arCOG01688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040537_0_0_2"/>
    <dbReference type="OrthoDB" id="114615at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="271" mass="30309" checksum="209725135107A587" modified="2007-02-06" version="1">MEKYKPYRVGRTVYAVGKTPVFFNISLSPAALEEVGVLERILEVFRRANVSILTFKVSGSRPGISEPGRVVLAADLTGRMGELRDLVSSLSSLPHVLSVETAPPLFDGFAMDLWSFPLLFDEKRVVFFDEEFLRGFILGGWRKLGDGYGGILFYSSFQAARRVFDEYIAPKSSKLEDRLLLVEEILRVFGLGVFKVSSYSEREVVVKVYDGTEAKALKGTEVPAEFITKGMLAGLVSGLWGAPYGEVWVEEKKCVLRGDEYCETHLKRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ18</accession>
    <name>A1RZ18_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752713.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1048"/>
    <dbReference type="EnsemblBacteria" id="ABL78448">
        <property type="protein sequence ID" value="ABL78448"/>
        <property type="gene ID" value="Tpen_1048"/>
    </dbReference>
    <dbReference type="GeneID" id="4600791"/>
    <dbReference type="KEGG" id="tpe:Tpen_1048"/>
    <dbReference type="eggNOG" id="arCOG02795">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773301_0_0_2"/>
    <dbReference type="OrthoDB" id="139581at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_9" evidence="2">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="16247" checksum="DEA5F60D27F7B049" modified="2007-02-06" version="1">MPDAAVNLLARLISRLELGEAASKVLAVLVLSEHPLSQLELVKATGYSLSQVSSALAFLTGLGFVSFVRSGRKKLYYSEKNITDLVGEIARRMLEQDIKPLIRELEKMPEKRERIRLLLDDCNLAAEKLQKSFLPGIVTGKKLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ46</accession>
    <name>A1RZ46_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="2">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752741.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1077"/>
    <dbReference type="EnsemblBacteria" id="ABL78476">
        <property type="protein sequence ID" value="ABL78476"/>
        <property type="gene ID" value="Tpen_1077"/>
    </dbReference>
    <dbReference type="GeneID" id="4601689"/>
    <dbReference type="KEGG" id="tpe:Tpen_1077"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_2"/>
    <dbReference type="OMA" id="HFWVPEV"/>
    <dbReference type="OrthoDB" id="98445at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proton_antipo_M" evidence="1">
        <location>
            <begin position="101"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="430" mass="44556" checksum="09531F8B45EE6ED1" modified="2007-02-06" version="1">MEKEIVTLVFAGSLAILSSGFLPGKASRYASTALSSAVMLALLYISLGNPGLAGYVGFVSSVIGLAAVISGLDLVEESKPLHDALVTVLTASLPLLLLLGDLLRLFVAWETISVCILALTAFHRDRESAEAAVKYIMLCGVASLLALAGIALSYLETGSLSVESFAKASLAAKMLVVVGFGAEAAVFPLHFWLPDAHMVAPSTASAVLSGITIEAAGLLVYRLVGSEPILLRLLSVLAVAGALLGNFSAYRQVDVKRLLAYSSVANVGYIFLGLTSGNATARTAAYLHVAGHGFLKAALFILSGVLLADFGSRRLDKLQGSLSGSKVLKAVLVVAALGLTGAPLALTFWSELYIIVGVAQSSLLLALLALTAVIASFGYYFNLVYALCVGEGSRPSGKPRLAAELSIVGLVALSASLLVLYGWIAGYFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ56</accession>
    <name>A1RZ56_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752751.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1087"/>
    <dbReference type="EnsemblBacteria" id="ABL78486">
        <property type="protein sequence ID" value="ABL78486"/>
        <property type="gene ID" value="Tpen_1087"/>
    </dbReference>
    <dbReference type="GeneID" id="4600935"/>
    <dbReference type="KEGG" id="tpe:Tpen_1087"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_2_2"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Proton_antipo_N" evidence="6">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="177"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="691" mass="74302" checksum="CBB598B9A7C77299" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ65</accession>
    <name>A1RZ65_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752760.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1096"/>
    <dbReference type="EnsemblBacteria" id="ABL78495">
        <property type="protein sequence ID" value="ABL78495"/>
        <property type="gene ID" value="Tpen_1096"/>
    </dbReference>
    <dbReference type="GeneID" id="4600963"/>
    <dbReference type="KEGG" id="tpe:Tpen_1096"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_0_2"/>
    <dbReference type="OMA" id="CTPGDTH"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="144"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="370" mass="41520" checksum="19F6EE52779E5E6D" modified="2007-02-06" version="1">MRIRVGLIGSGWSASAQAFSLSSLGRVVRRSGFPEVELRVVFSRTPAHAEALARQYGFEKWTTSESEFFGEDLDVVGIASPNNTHYPYALRALERGFNVVLEKPVAFNAREAEEIERYSRRVGRSVAVCLVSRFTPGIQVLRDLVVRGELGDFLEFRGVIAHAKHAYKDTPFEWRMDRSVAGGGVFADIGVHVLDLSEYVTGGRVRRVFGKVYTLVGERVDPATGLKRRVDTEDIGFAVLEYEAGAVGSVEASKVSPGFEEQMRVEVYGDRGGARFSLSEPHVLHLYRRETGRTEKIVKGYEEIYGDLAWPLPKSFEGWVFSYVILYKTFFEYLSGLREDYHPTISDGVRSQKLLDAVYESSSSGKWIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ74</accession>
    <name>A1RZ74_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752769.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1105"/>
    <dbReference type="EnsemblBacteria" id="ABL78504">
        <property type="protein sequence ID" value="ABL78504"/>
        <property type="gene ID" value="Tpen_1105"/>
    </dbReference>
    <dbReference type="GeneID" id="4601099"/>
    <dbReference type="KEGG" id="tpe:Tpen_1105"/>
    <dbReference type="eggNOG" id="arCOG00188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="YEACPND"/>
    <dbReference type="OrthoDB" id="25719at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="294"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="327"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="541" mass="59077" checksum="64EBE670B7AE7240" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA3</accession>
    <name>A1RZA3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1135"/>
    <dbReference type="EnsemblBacteria" id="ABL78533">
        <property type="protein sequence ID" value="ABL78533"/>
        <property type="gene ID" value="Tpen_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1135"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="364" mass="37959" checksum="AABBAE8038F7530F" modified="2007-02-06" version="1">MSGRLAYALSFSMSLLQSLMIPVLVLYMLQLGYTEAEVGLVTGTASAVYIAGALLSSVLAGRLGDSKTILLSLASMATGYALLSASTGLYAILLASGVVLLGFGVFWPAVENLVSSSGGKVSAFSFSWSSGSLAGMLLVYPLSLLDPRALYAAFSASSLLLALSVRRGEERARARATFGDVLSSLYSLRASWVLCVAYSLSSSGLITFYPVLVERAGLPRFMLSLALFLMILSRTAVFFAYDALPAPLKRVEIAAPVLLASSLIPFVDNPFLHLPLSLIAGAGQGVIYGIALEGVFKSGSDRVHNYTALFESFIGAGYSLGPLLAALLGEYAGLQPLLSTSLLASLAALLAGRKPRGSAPASRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC6</accession>
    <name>PYRI_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrI</name>
        <name type="ordered locus">Tpen_1158</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752821.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZC6"/>
    <dbReference type="SMR" id="A1RZC6"/>
    <dbReference type="STRING" id="368408.Tpen_1158"/>
    <dbReference type="EnsemblBacteria" id="ABL78556">
        <property type="protein sequence ID" value="ABL78556"/>
        <property type="gene ID" value="Tpen_1158"/>
    </dbReference>
    <dbReference type="GeneID" id="4602160"/>
    <dbReference type="KEGG" id="tpe:Tpen_1158"/>
    <dbReference type="eggNOG" id="arCOG04229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_2"/>
    <dbReference type="OMA" id="CPNRNCI"/>
    <dbReference type="OrthoDB" id="101957at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000000053" description="Aspartate carbamoyltransferase regulatory chain">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <sequence length="159" mass="17481" checksum="C0DAF2A3137AA881" modified="2007-02-06" version="1">MEEGLLVRKIREGTVIDHIPAGRALNVLKILGLTGREGLTIAVVMNVPSRKLGVKDIVKVEKRFLEPSEVDKIALIAPSATINIIRDFQVASKRRVEPPAVVTGILRCPNPNCVTNSEREPVTPRFVRVSLSPLKLKCAYCEETLSEAEIVDQLVSPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE0</accession>
    <name>A1RZE0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752835.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1172"/>
    <dbReference type="EnsemblBacteria" id="ABL78570">
        <property type="protein sequence ID" value="ABL78570"/>
        <property type="gene ID" value="Tpen_1172"/>
    </dbReference>
    <dbReference type="GeneID" id="4602038"/>
    <dbReference type="KEGG" id="tpe:Tpen_1172"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="IRFGGHV"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="26700" checksum="3B96E94CC0063333" modified="2007-02-06" version="1">MYAVQVENLTKVFGNFQALRGVSFAVEEGEVFGLIGPNGAGKTTTFRILAGLLPPTSGKVLVLGKAPGSPELKRVVTYLPEDAGTYRNLTGYEFLRMVSELYFGRSREAEEALELGVKIASLGEKIHEKMKGYSKGMKRRIQVARALMVKPRLAILDEPTVGLDVVHAKEIRTLIKEFAREHGSTILLSSHNMLEVEDVCGEVAIIDRGVVLLQGKVRDLLSEHGARNLEELFFMVAGRGEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE3</accession>
    <name>A1RZE3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752838.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1175"/>
    <dbReference type="EnsemblBacteria" id="ABL78573">
        <property type="protein sequence ID" value="ABL78573"/>
        <property type="gene ID" value="Tpen_1175"/>
    </dbReference>
    <dbReference type="GeneID" id="4602041"/>
    <dbReference type="KEGG" id="tpe:Tpen_1175"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="OMA" id="VSFGMIV"/>
    <dbReference type="OrthoDB" id="42276at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="304" mass="34174" checksum="9343CDAFBB3E8F31" modified="2007-02-06" version="1">MVRLSRRMSKYLVMALFLLPAAAIIVLFLVVPSVLTILISLTNLDYRFKWEWVGLSNYQTFVSDPNTPIFVRNTIIYVTGTLAFNVGVGLLLALLSTHVHDALGTFMRAAWYLPRVLPSVIWAFVMMWIFSPMDTGFLNSLLKSAGLSPVPWTFKYYWPFLYIVNGFIGCSLGMVIFSSAIKSIPQDLIVAAKVDGASGLTIVRRIILPLIKWHIAFVVAYQTLSLLASFEYILLTLDGGPGYYSTEVMILQAYHLAFGQYLAAMRYGYAAVFVTILLVIGLVLSVVYWKVFRLHKLMAEPVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE8</accession>
    <name>A1RZE8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1180"/>
    <dbReference type="EnsemblBacteria" id="ABL78578">
        <property type="protein sequence ID" value="ABL78578"/>
        <property type="gene ID" value="Tpen_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1180"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OMA" id="IVWNFTN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="60"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="418" mass="45667" checksum="8F7F3010E9B9C7EF" modified="2007-02-06" version="1">MGVRMSRVLPWYVPPTLFVRQVLSAATVRSATGWSPGSRWVKSLSSLLRSANGAKAMGCFGYAPHPVYEVTAACNLRCAHCHASAGRPYPGELDTEGAKRVIESLTTVKDFRTLVFTGGEPLVRKDIWELTRHAVDLGFGVVFATNGVLVSESVAAEMRRLGVLGAAVSLDSSRPLVHDKLRGVPGAWRGAVRGIKNLLKEGLYVQVNITANRLNVDEIEDVVRLADSLGSHVIFLYTFVSVGRGSSNDWLSLTPEEFVKLSRRILKVQGEVQSLIIPVAMPWYFPLLLQEARLKPEVASRWVSGCIAARGMFYVKPNGDAWPCAFIPVSGGNVARQPAIEVWEGDLFKAIRNRENLEEPCRSCRFREVCGGCRSRAYLATGRLTAPDPLCPLVRRRLSTSTAPSGPLQPAAKSGEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE9</accession>
    <name>A1RZE9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752844.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1181"/>
    <dbReference type="EnsemblBacteria" id="ABL78579">
        <property type="protein sequence ID" value="ABL78579"/>
        <property type="gene ID" value="Tpen_1181"/>
    </dbReference>
    <dbReference type="GeneID" id="4602047"/>
    <dbReference type="KEGG" id="tpe:Tpen_1181"/>
    <dbReference type="eggNOG" id="arCOG08832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594002_0_0_2"/>
    <dbReference type="OMA" id="NFIDERA"/>
    <dbReference type="OrthoDB" id="133019at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="460" mass="51623" checksum="91629210579753F8" modified="2007-02-06" version="1">MTHVKSVGRALLLAVLVLILVASLALYNGFQQAFSEYAHCNGGYWKDSNNTHLVQDAKWRKTVNVYVIGVGDRTGKAESALHKLGLNVKVSSVLDRSGIEWSDVVLIDSDWAGSIGVRYRELVKDTVRLRKPVACYGSDAGNKFIELVGRDFFLNELSLYIGGEPFSNKTPNLELPADVKLFSIITRRSQGDLLVPEYLVIESIEEDLERDIAELLNWLIDLGIVDGEVKHYSITEVNGFKYVGSIDWKTYYIKYCNNNVGKLQAKSEYYYYGERVGEVFYKWFLIYVNHLTTGYGATTWCGACPYANWALHKAKTEIDGHTDTFPGQVFDDMGPINAMTCVSSISYEVSAEVSGVIARVSVSYNPNQMSYTSSVDVDTGIVKWIHSPCQHVTDTTWRVEPSAIFYLDPRKEYGYEPLIVTHYFYSEVKGYTTPRCGGTAYTYGQSSYTAYVKSSEVSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG7</accession>
    <name>A1RZG7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752862.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1199"/>
    <dbReference type="EnsemblBacteria" id="ABL78597">
        <property type="protein sequence ID" value="ABL78597"/>
        <property type="gene ID" value="Tpen_1199"/>
    </dbReference>
    <dbReference type="GeneID" id="4600391"/>
    <dbReference type="KEGG" id="tpe:Tpen_1199"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_5_2_2"/>
    <dbReference type="OMA" id="GEWAVRI"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="423" mass="46620" checksum="BF8464047C8FDD99" modified="2007-02-06" version="1">MYDLVVVGGGPAGSSAAIAAARAGLSVVVLEKGERNRDKYCGGGISVLTQNSLRELGAAEALETFENYAEGHVLVLPGEKVLVDAIPGLGYGLVRRSVFDAKLRELAESYGATVKHGFEASSITVDGDKVVVRSRKGEVVEGRYAVVATGAGNFPERALGFPPLRPENLGHCWGTEAEYPVSAEVERWRHEYGFTPIFLMFGFVTYGYMWVFPKRNHMNVGMGTTLAESARYGRLHLEGFARGLELARRMGILSEPGRLRVDRSWLIPGKPRAVTYSQERRVLLAGDAAGFVHPLTGEGISGAVRSGRLAAETVKQALDKEDPGLLKEYEAKWWADFGEDAYAYGLKLTRLMYSSPALQRLGLSMVFSDEEASRLLSMLLYRADRSASRRLYEYLLKHFPELLLKQPFAGKKRDYSKKRLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG9</accession>
    <name>A1RZG9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752864.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1201"/>
    <dbReference type="EnsemblBacteria" id="ABL78599">
        <property type="protein sequence ID" value="ABL78599"/>
        <property type="gene ID" value="Tpen_1201"/>
    </dbReference>
    <dbReference type="GeneID" id="4600393"/>
    <dbReference type="KEGG" id="tpe:Tpen_1201"/>
    <dbReference type="HOGENOM" id="CLU_1149858_0_0_2"/>
    <dbReference type="OrthoDB" id="135687at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="241" mass="26087" checksum="33B3909473385AD8" modified="2007-02-06" version="1">MSLYKLVVFAGAKGSGKSSLIKALFPELDVRFDEPSYYRDYPLSGGVVVREVAGRHESLDVVSTIAGRWRISVGVLVADASQPFQRALEPKALVVVENAERKCLVAAKADSPYGDTVARLKGFAGERGFEFFAASVKDPGSIEELRLWVLEGRRPEVRKPEQPRAVAPPVPVDLVPVPAPKAPGKGALSEEELAVFELCDGKRGLAEIARITGKSYGEVKRIADSLMTKGFIAGFKTRVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI3</accession>
    <name>A1RZI3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose/GDP-mannose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752878.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1215"/>
    <dbReference type="EnsemblBacteria" id="ABL78613">
        <property type="protein sequence ID" value="ABL78613"/>
        <property type="gene ID" value="Tpen_1215"/>
    </dbReference>
    <dbReference type="GeneID" id="4601627"/>
    <dbReference type="KEGG" id="tpe:Tpen_1215"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080091_0_0_2"/>
    <dbReference type="OMA" id="GHCLIPN"/>
    <dbReference type="OrthoDB" id="72966at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="2">
        <location>
            <begin position="154"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="275" mass="31279" checksum="40AC6E6A83948AE3" modified="2007-02-06" version="1">MERVLVVGLGEVGSAVYEVLRDSGRMEVYGYDLDPSKTVHRLEDVPAPLDYLHVAIPFTPRFVDAVKSYAEKLKPRAVFVHSTVAPGTTRLLHGEARLPVAYTPVRGKHPNLKKHLLFWPKWVSAVPEGFTEEAKRHLEAAGFKVKLASSPESLEIAKLWETVYRAVMIASWQELHRVAARYGADIRVVAEFIAEVHEVLGDRPVYFPDYIGGHCLIPNTEILNKAYPSKLFEFVLESNEKRRKEVEDPRVKREIEDTKKLFLKLTRADYYGGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ0</accession>
    <name>A1RZJ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752885.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1222"/>
    <dbReference type="EnsemblBacteria" id="ABL78620">
        <property type="protein sequence ID" value="ABL78620"/>
        <property type="gene ID" value="Tpen_1222"/>
    </dbReference>
    <dbReference type="GeneID" id="4601719"/>
    <dbReference type="KEGG" id="tpe:Tpen_1222"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="NDMFEAE"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="35680" checksum="87D73B302F74A939" modified="2007-02-06" version="1">MSRGVAVKISNFVKKFGDTVAVDGLNLDIYEGEIFGLLGPNGSGKTTTLLTIATVYKPTSGDIYVHGYSVSRQGDIVRKYVGIAFQEPKALWVDTPYELLLWHARVVGYSSSEARAVVKEVMEQLNLWEHRKKQFYQLSGGTRKKLEIAKVLIQRPKVAIFDEPTAQVDVLTKHALWDIIRGLRDEGTTVIVATNDMFEAERICERLGIIYKGKLRALGTVSELKDMVPAGDVIEISFEGPEENVRKLLSELEGVSNYTVTDHSLRIHLNRGEERAAEIVELLASSGVKVRKLMVHEPTLDDVFFYFTGARLREEHGAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ9</accession>
    <name>G1PDH_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="1">G1P dehydrogenase</shortName>
            <shortName evidence="1">G1PDH</shortName>
            <ecNumber evidence="1">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egsA</name>
        <name type="ordered locus">Tpen_1231</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RZJ9"/>
    <dbReference type="SMR" id="A1RZJ9"/>
    <dbReference type="STRING" id="368408.Tpen_1231"/>
    <dbReference type="PRIDE" id="A1RZJ9"/>
    <dbReference type="EnsemblBacteria" id="ABL78629">
        <property type="protein sequence ID" value="ABL78629"/>
        <property type="gene ID" value="Tpen_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1231"/>
    <dbReference type="eggNOG" id="arCOG00982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="OrthoDB" id="57545at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000350663" description="Glycerol-1-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <sequence length="347" mass="36660" checksum="A06DF0E00A2C68D8" modified="2007-02-06" version="1">MRAELPKRVVVERGALQFLPEVLRELGCSKTVVVTDSGVWSVVGSVVEGALRGLAYEVVYIEAADNSNVERARSAARRVEACAVAGLGGGRPVDVAKYAAFMEGLPFVSVPTAISHDGFASPIVALKDPEGNPLSIFTRPPAAVLVDLAVVSRAPRRLLASGVGDIVGKVTSVADARLAQRLTGEEVPEVALRMAETAARMVLDEVDEIASWTERGVGVLAQAGLLAGMAMAVAGSSRPCSGSEHLFSHSLDKYVPWKKSLHGEQVGVGAIIASYLHGFNWRVIRDALAKVGAPTTVEGLGVTGEDAVRALLKARELRKRFTILDVVELNEGLAWKVLRETGVAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK4</accession>
    <name>A1RZK4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752899.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1236"/>
    <dbReference type="EnsemblBacteria" id="ABL78634">
        <property type="protein sequence ID" value="ABL78634"/>
        <property type="gene ID" value="Tpen_1236"/>
    </dbReference>
    <dbReference type="GeneID" id="4601168"/>
    <dbReference type="KEGG" id="tpe:Tpen_1236"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_2_1_2"/>
    <dbReference type="OMA" id="NCLEVIH"/>
    <dbReference type="OrthoDB" id="90041at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="5">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="6">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14705" checksum="56D140D8342A4C0C" modified="2007-02-06" version="1">MRRISLTVPDEVYKALEELAERTRISNRSRLVSDAIMAYASQSLEDGARYAGAIIVLYDHSRGETVYGVTDAQHDYPEISASLHMHLSEDLCLEVLGVRGEGGRLKNLISALRGVSGVITVQYSLVRLDQAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP2</accession>
    <name>A1RZP2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752937.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1274"/>
    <dbReference type="EnsemblBacteria" id="ABL78672">
        <property type="protein sequence ID" value="ABL78672"/>
        <property type="gene ID" value="Tpen_1274"/>
    </dbReference>
    <dbReference type="GeneID" id="4600741"/>
    <dbReference type="KEGG" id="tpe:Tpen_1274"/>
    <dbReference type="eggNOG" id="arCOG02441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527494_0_0_2"/>
    <dbReference type="OMA" id="RTTIIMI"/>
    <dbReference type="OrthoDB" id="127893at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="485" mass="50937" checksum="B6BFE45A08B097DD" modified="2007-02-06" version="1">MRTLLYDFRRALLNSSTLVLLAALVAVGAAVGYMAYAQMTGQGKLFGIAYTVTPNSSAVKVEGLVYDYTGNPVKDNTVTVKLLECSEGGAGASMPACSVVAEWTARTGERFKAELRRGSTNASVNLEIRVANRYGSSLSWSSGIRCFPADMHTSLGIGFGSTFNKTWLAVGEVIPLEGGGYRLAVAVAPPDCNYSEVAGSKLYYTVYNETPGRLAYAGELGASGVGVFDLKAAGSGKALYLELETRRGRVRLDTPVSLAGSSALKGWIVAAMLVSSNVLAFLYPIAVMLTAYNLVAKPRSTGALEFVLARPVTRLQLFLSRFAAGALASAASPLLATAAMHLVISWAVGSPPPLEDSALLAAGIAASMLAYYSVFYSIAASAKGKSYLLLAVVVYIVFTVLWAPIAFAIAVAVRGTPDPAAVQQAYYFNPSVAFQAATEALHLKYGQAAVQAALKPAYVAAAAAAWVLLPLVAAWLAFRKANLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ5</accession>
    <name>A1RZQ5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein, SSO1426 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1287"/>
    <dbReference type="EnsemblBacteria" id="ABL78685">
        <property type="protein sequence ID" value="ABL78685"/>
        <property type="gene ID" value="Tpen_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1287"/>
    <dbReference type="eggNOG" id="arCOG02658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084207_1_0_2"/>
    <dbReference type="OMA" id="YCIPCII"/>
    <dbReference type="OrthoDB" id="98478at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013411">
        <property type="entry name" value="CRISPR-assoc_RAMP_TM1809"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02581">
        <property type="entry name" value="cas_cyan_RAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="26412" checksum="549723054E0D4538" modified="2007-02-06" version="1">MQYNDLDRLDLFTRVTGVLENLTPLRVGAGREAQLGSPVDLEPLRVRLGDRSVPYIPGSSLKGVFRSLAEAIARAEGHVIHDPWDFEAAEQEARDGKYCLICGIFGSTRLASHVRIYDAYPKGTPTLFMKTGVGINRDFRGAHPNILYTERQVEPGHRWSFMMDIVNIRVYPEPGDERGRILRRVLDMLAEGMVQVGARKTVGYGLLRLVEGEYVVYGVRDGRLQRLESGKIGGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS5</accession>
    <name>A1RZS5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752970.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78705">
        <property type="protein sequence ID" value="ABL78705"/>
        <property type="gene ID" value="Tpen_1307"/>
    </dbReference>
    <dbReference type="GeneID" id="4601601"/>
    <dbReference type="KEGG" id="tpe:Tpen_1307"/>
    <dbReference type="eggNOG" id="arCOG03755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185777_0_0_2"/>
    <dbReference type="OMA" id="READWEF"/>
    <dbReference type="OrthoDB" id="129136at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="80" mass="9642" checksum="888188093318904A" modified="2007-02-06" version="1">MRGESLDDVVREYLEEEREAREIRRRMADWEFIERQPPRVRAALKLYVEKGDIRLTSRIAGMNIDEFRELLRKARIPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU1</accession>
    <name>A1RZU1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752986.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1324"/>
    <dbReference type="EnsemblBacteria" id="ABL78721">
        <property type="protein sequence ID" value="ABL78721"/>
        <property type="gene ID" value="Tpen_1324"/>
    </dbReference>
    <dbReference type="GeneID" id="4601563"/>
    <dbReference type="KEGG" id="tpe:Tpen_1324"/>
    <dbReference type="eggNOG" id="arCOG05134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1222580_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="226" mass="25142" checksum="92D403953974DECD" modified="2007-02-06" version="1">MVFFYRAELRLKGFLWYHTLARATESFYTHSVVPVVHNYGLTLALAGYDADPAFGYVSIYGRKGYRSLLELFREHGVYAYPAIAKRAYTQEVIMSAIGESTVQAKGKGRLSYPDFTKNVVLAPGSILETLIVSEGELPSRFAVRIGAKRAGTLWVELTRVPVDIANNRKVTHPFNVNDVVRVDGYTVLLRHEAGDVGIFGVAEEAYVVPVRDSKTKEVVVPALKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX0</accession>
    <name>A1RZX0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753015.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1353"/>
    <dbReference type="EnsemblBacteria" id="ABL78750">
        <property type="protein sequence ID" value="ABL78750"/>
        <property type="gene ID" value="Tpen_1353"/>
    </dbReference>
    <dbReference type="GeneID" id="4602190"/>
    <dbReference type="KEGG" id="tpe:Tpen_1353"/>
    <dbReference type="eggNOG" id="arCOG01443">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003331_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="277" mass="30371" checksum="C1C822E986048D93" modified="2007-02-06" version="1">MEVPECVALARRLGLPEGARPCPGCRGPPLPSYFREGRGLGCWVAHTALSAVEAADLAEELDPLLRRLGLRGSVLDAALLHDVGKLTEEYVERAYHYHNFASAVVAEDVLARMGVGEDRFVVASAVLLHHEARHWEELLREPLPGHVIETLRGGPFRLHRSARAALEALSGLLERAGLGSEVPRLVGEKEVYEVKREVKVKIARVAVPERVLPLYWVLYEADNRAASAREGRYWLWSLGEAGRRDPLRLAGEALGQGLLAGLTAVSVPLRRARGVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX3</accession>
    <name>A1RZX3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated autoregulator, DevR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753018.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1356"/>
    <dbReference type="EnsemblBacteria" id="ABL78753">
        <property type="protein sequence ID" value="ABL78753"/>
        <property type="gene ID" value="Tpen_1356"/>
    </dbReference>
    <dbReference type="GeneID" id="4602193"/>
    <dbReference type="KEGG" id="tpe:Tpen_1356"/>
    <dbReference type="eggNOG" id="arCOG03617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054331_1_0_2"/>
    <dbReference type="OMA" id="MIYYVET"/>
    <dbReference type="OrthoDB" id="47264at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002764">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-a/Apern"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01905">
        <property type="entry name" value="DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02583">
        <property type="entry name" value="DevR_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="325" mass="35912" checksum="C3E997ABCFCC0737" modified="2007-02-06" version="1">MVYVRVTGRAIVNVHSANAEGAVGNYTGLSRVFVVKRRGSGYEVVEEPVISGNMVKHWHAVRMVEILKEVGGGKARLCDNCKRFIMYRSTMNFNDEFEYVKACAIEDVHGFLQPDAGVRRESLVKFSFMVPVEELDAGSTAVTHNRVFLDERGSVPREQQAMMVFKREHASGLYGFSAVMDLKYVGRPLADPDNANKVLPLDERRLRAKAALLAMADVLSGRFGAASARALPIVKVEELVCAVGRQPIPSLVHGFYSDYAEESYRLLRGFLSAGAAQDVKVFVYGRRVAEVFSGLSEVRRDAVKEVGSPVEAFVEAAKVAEEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX5</accession>
    <name>A1RZX5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1358"/>
    <dbReference type="EnsemblBacteria" id="ABL78755">
        <property type="protein sequence ID" value="ABL78755"/>
        <property type="gene ID" value="Tpen_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1358"/>
    <dbReference type="eggNOG" id="arCOG01446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178175_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010163">
        <property type="entry name" value="Csa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01884">
        <property type="entry name" value="cas_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="235" mass="25338" checksum="46E5FD7BFBB9AC1D" modified="2007-02-06" version="1">MTLGAPTARLFRGRGGAIRVIDALVLTLGFEPGPLISAVASAASEGLAEGARVVVLTAGFPDERAERAWLEFQRVVGMMGLARRPGFSVEKREVPLDDFVAAVINVKSLFRGLEDKRVRISITGGMRALGIAVLTAYLLTRWRVDPEVEVYLEGQGRALRLPRLSRVLGVGVPEAWLEVLSALEKSGPLGASDLGGLLGKDRSTVFRYLKRMEEAGLVRQVDGGYVATDLGRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ2</accession>
    <name>A1RZZ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1375"/>
    <dbReference type="EnsemblBacteria" id="ABL78772">
        <property type="protein sequence ID" value="ABL78772"/>
        <property type="gene ID" value="Tpen_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1375"/>
    <dbReference type="eggNOG" id="arCOG00754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_2"/>
    <dbReference type="OMA" id="MGRCQGF"/>
    <dbReference type="OrthoDB" id="9099at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="387"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="461" mass="50831" checksum="72A7813573077195" modified="2007-02-06" version="1">MYDVVIVGSGIVGLMTAYRLSRYKLRVLVVDSNPEPGWGVSKGHAAIVHVVQLPFSSLKSRMAREGNRLLGEVARELGVRLERTSTLVVATKLHHLLALPLVALYLRLNLGKEFPVKLRGRGYLRREEPGLTRKALGAVEVYGYGCVDNFDLLYGLYEFASANGVEFRFGERVVAARVLEDRVEVETDKGNVYEAGFLVNAAGLWADEVARFTGDEASFELGKGVLLVFDRRHTRRFVAPAYLKPDPKTKGGAVMFTVDGRGLWGPNLRPARDKYDVCVDEEDVEMLYRKFAPLLEGDPGIPLKAYAGVRPIPPENDFRITYSKSSRRVVHAIGTESPAFTASPAIADRIVSMLGDAGLRLEPKEKLAPRKPFPRARDNPEKARGRVVCTCSLVTEEEVREAVRRGSRTLQGVMFRTGACMGTCQGARCIAEVARIVAEELGVGVEELTLRGGGSWLVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ7</accession>
    <name>A1RZZ7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753042.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1380"/>
    <dbReference type="EnsemblBacteria" id="ABL78777">
        <property type="protein sequence ID" value="ABL78777"/>
        <property type="gene ID" value="Tpen_1380"/>
    </dbReference>
    <dbReference type="GeneID" id="4600368"/>
    <dbReference type="KEGG" id="tpe:Tpen_1380"/>
    <dbReference type="eggNOG" id="arCOG00031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086256_0_0_2"/>
    <dbReference type="OMA" id="HVARNIG"/>
    <dbReference type="OrthoDB" id="106448at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="246" mass="27591" checksum="63F78F53E129DE9D" modified="2007-02-06" version="1">MAGEVEESSYIVAKLLNCLKEVYTFKELEEALGVSSQILWRYTTFTQFPERQTARKILDGIREKRLLERAFKEMVIGERKTVEEWRFLFNPRFLNLVGYLAWKKFRDDGVDVVLAAGEKNAALAAILAEWLSAESYVASEHAWSSWGKLYSASYSSSEREEIVYLHVPREALKRDSKVLFAKGVARNFESLAALRSIAEQAKAVPVGAVVAVSLSGEWMGLAEKAGLRKVYVASVVADGNVFVNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S009</accession>
    <name>A1S009_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753054.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1392"/>
    <dbReference type="EnsemblBacteria" id="ABL78789">
        <property type="protein sequence ID" value="ABL78789"/>
        <property type="gene ID" value="Tpen_1392"/>
    </dbReference>
    <dbReference type="GeneID" id="4600675"/>
    <dbReference type="KEGG" id="tpe:Tpen_1392"/>
    <dbReference type="eggNOG" id="arCOG09752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119855_0_0_2"/>
    <dbReference type="OrthoDB" id="131804at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14738" checksum="7D79F22BEAF416BC" modified="2007-02-06" version="1">MEAGASGSQQPQQGRKRPLGVTILAYLYLFSGIFVLGMVQAMMAENLPAETFLAWLLYGVALMATGVGFMYGMKWAWWLAVVNQSLSALIMLVLTVINDPIWLFGLFISLVVLYYVLRPHVKEFFGVEAGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1S025</accession>
    <name>A1S025_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate dehydrogenase alpha subunit</fullName>
            <ecNumber evidence="7">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753070.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1408"/>
    <dbReference type="EnsemblBacteria" id="ABL78805">
        <property type="protein sequence ID" value="ABL78805"/>
        <property type="gene ID" value="Tpen_1408"/>
    </dbReference>
    <dbReference type="GeneID" id="4601822"/>
    <dbReference type="KEGG" id="tpe:Tpen_1408"/>
    <dbReference type="eggNOG" id="arCOG01491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274368_0_0_2"/>
    <dbReference type="OMA" id="KWDGAKW"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131252" checksum="59DEDA75BBFDC3C2" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S046</accession>
    <name>A1S046_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1429"/>
    <dbReference type="EnsemblBacteria" id="ABL78826">
        <property type="protein sequence ID" value="ABL78826"/>
        <property type="gene ID" value="Tpen_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1429"/>
    <dbReference type="eggNOG" id="arCOG01423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998851_0_0_2"/>
    <dbReference type="OMA" id="GHKSEVE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012431">
        <property type="entry name" value="PDDEXK_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07788">
        <property type="entry name" value="PDDEXK_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="124" mass="13808" checksum="5A11B88F0251081A" modified="2007-02-06" version="1">MVVSHRFGVLTESAFREAMKYVVEEVLGAGAVRRVTMYDEEGLVYGHKSEVEVDLVVRDREHILVEVKSRVSRGDVAELYRVGLLYEKLYGVKPRLVLVGGFIDTDAWETAGALGVALKPALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S049</accession>
    <name>A1S049_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78829">
        <property type="protein sequence ID" value="ABL78829"/>
        <property type="gene ID" value="Tpen_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1432"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2505135_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="10240" checksum="66B8FC86C1894FCD" modified="2007-02-06" version="1">MRHMGFMPRIHDIRELLAIIYKYTRDSRVDELMRRFRRELRDLVEGYVVARYGSIDYSRDDAEVCIGLMRDLWRLIESVEGGCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B5</accession>
    <name>A1S0B5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753160.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1498"/>
    <dbReference type="EnsemblBacteria" id="ABL78895">
        <property type="protein sequence ID" value="ABL78895"/>
        <property type="gene ID" value="Tpen_1498"/>
    </dbReference>
    <dbReference type="GeneID" id="4601407"/>
    <dbReference type="KEGG" id="tpe:Tpen_1498"/>
    <dbReference type="eggNOG" id="arCOG02284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015706_0_0_2"/>
    <dbReference type="OMA" id="FQGAYVY"/>
    <dbReference type="OrthoDB" id="4397at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="682" mass="72371" checksum="7352434456B58361" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D5</accession>
    <name>A1S0D5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase, DHHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1518"/>
    <dbReference type="EnsemblBacteria" id="ABL78915">
        <property type="protein sequence ID" value="ABL78915"/>
        <property type="gene ID" value="Tpen_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1518"/>
    <dbReference type="eggNOG" id="arCOG00424">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071985_0_0_2"/>
    <dbReference type="OMA" id="HDTCCSA"/>
    <dbReference type="OrthoDB" id="90483at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="199"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="312" mass="33354" checksum="675607C5D42D656D" modified="2007-02-06" version="1">MAGVILAHGDSDGVTAAAIAKSVYRDAEVFFTHPVGLAKDLEEFARGRSPVIILDVAVDEAGAPRLAEVLRSLGAEVVYVDHHPGGEALEKIRVPGVRVVHEEGPCAAELAYRFFKPPREMSRVALYGAIGDHALGTAWVAEALEEWDLKTLFFDAGVLVLALEALGRDYESKRRVVDLLAGGGVPSREKSLVELAARQSLLNEELRVRVREKALVVGQVAYVMDPGGSLGTAAFYARVERGVKVGVAVERRGETCVMSLRSTGGVDLNALLRRIAPRHGGHGGGHRQAAGARIPCGELEKFLAELAASLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D9</accession>
    <name>A1S0D9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753184.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1522"/>
    <dbReference type="EnsemblBacteria" id="ABL78919">
        <property type="protein sequence ID" value="ABL78919"/>
        <property type="gene ID" value="Tpen_1522"/>
    </dbReference>
    <dbReference type="GeneID" id="4600659"/>
    <dbReference type="KEGG" id="tpe:Tpen_1522"/>
    <dbReference type="eggNOG" id="arCOG05799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992556_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021683">
        <property type="entry name" value="DUF3267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11667">
        <property type="entry name" value="DUF3267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="280" mass="29311" checksum="FD04181731B2910D" modified="2007-02-06" version="1">MQGERCYVSVKESLAAVAGFALLLFYVAVLLLGSFTPPADLVVFALGVLATLALHEGIHVAVAYAFGARGISVKPFRASWILVGVYVSTKTSLRRDEWLVVALAPLLVLTPAALVAAKTLEGLARETAEFIVVFNTMGAGGDLFLALAVLLSAKRDALIHDEGERVVFEGSCSRVAALTSIGKAVLAFSATFCCLWLGVLALCAFLRLDVEALGVRLIETEKAAGYAARLTNAGLATFLAVALIAALLVGLAEYKKLGRMGEASAKAGEKKDNFSATASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K1</accession>
    <name>A1S0K1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyroglutamyl-peptidase I</fullName>
            <ecNumber evidence="6">3.4.19.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753246.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1586"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="ABL78981">
        <property type="protein sequence ID" value="ABL78981"/>
        <property type="gene ID" value="Tpen_1586"/>
    </dbReference>
    <dbReference type="GeneID" id="4600550"/>
    <dbReference type="KEGG" id="tpe:Tpen_1586"/>
    <dbReference type="eggNOG" id="arCOG05850">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_2"/>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="OrthoDB" id="97570at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="208" mass="22721" checksum="14BC21631D7EDA3E" modified="2007-02-06" version="1">MRILLTGFGPFGEEDVNPSSTVAIEASRRLREAGYEAKALELPVSYRRAGQMIENAVAEYKPWLAIALGLYGGVTHVRVERVALNIMDFSTSDVDGAQPVDEPVDPEGPPAYFSSIPTRRVVERLRAEGIPAALSYSAGTYLCNYVMYKLLRLSDVRGAPVRAGFIHLPYTPELASRKKGLPPSLPLELQVKAVLIAVEESLKNAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L8</accession>
    <name>A1S0L8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753263.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1603"/>
    <dbReference type="EnsemblBacteria" id="ABL78998">
        <property type="protein sequence ID" value="ABL78998"/>
        <property type="gene ID" value="Tpen_1603"/>
    </dbReference>
    <dbReference type="GeneID" id="4601534"/>
    <dbReference type="KEGG" id="tpe:Tpen_1603"/>
    <dbReference type="eggNOG" id="arCOG10125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599098_0_0_2"/>
    <dbReference type="OMA" id="IGWFIIK"/>
    <dbReference type="OrthoDB" id="123051at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="167" mass="17714" checksum="FE1A3A2475284307" modified="2007-02-06" version="1">MLVLGFADYVLMIVLGFVTAVWGYRIARLWVSFISAIAVGYAFYAFSTPALKSALTPLVLFLIGFFVGALIGFAVFKLAVSLIAGFAIAYALESHGYVVPGEGPLLVLALVFALLIYAVIDKLLVLAFALAGSSMVFLGLRGVGLPLYVSLALSALLAVVALYKNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P3</accession>
    <name>A1S0P3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase, family 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753288.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1628"/>
    <dbReference type="CAZy" id="GH38">
        <property type="family name" value="Glycoside Hydrolase Family 38"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79023">
        <property type="protein sequence ID" value="ABL79023"/>
        <property type="gene ID" value="Tpen_1628"/>
    </dbReference>
    <dbReference type="GeneID" id="4601031"/>
    <dbReference type="KEGG" id="tpe:Tpen_1628"/>
    <dbReference type="eggNOG" id="arCOG03661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_0_2"/>
    <dbReference type="OMA" id="SWEQREA"/>
    <dbReference type="OrthoDB" id="20900at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="522"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116079" checksum="25B9E1C69F41E881" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q3</accession>
    <name>A1S0Q3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753298.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1638"/>
    <dbReference type="EnsemblBacteria" id="ABL79033">
        <property type="protein sequence ID" value="ABL79033"/>
        <property type="gene ID" value="Tpen_1638"/>
    </dbReference>
    <dbReference type="GeneID" id="4600917"/>
    <dbReference type="KEGG" id="tpe:Tpen_1638"/>
    <dbReference type="eggNOG" id="arCOG01534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_2_2"/>
    <dbReference type="OMA" id="YDFFTWE"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="81"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="529" mass="59630" checksum="5E9BAF1CA555EDE0" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S5</accession>
    <name>A1S0S5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1660"/>
    <dbReference type="EnsemblBacteria" id="ABL79055">
        <property type="protein sequence ID" value="ABL79055"/>
        <property type="gene ID" value="Tpen_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1660"/>
    <dbReference type="eggNOG" id="arCOG04213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OMA" id="YEVNAFY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="1">
        <location>
            <begin position="209"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="387" mass="42467" checksum="39A00FB5597D9F5A" modified="2007-02-06" version="1">MAVDVVRVALVGQGYVATIFAWGLCKLKKGEIEPWGVPLADVDFGVPVEDLEIAGSVDVDERKVGKSLREVAPMYGLSPEPELGEVVVAPGLKLRSTPGFIRTKALDDSKPLADAYGAFEEWLDDVKPDVVVDVTSTVASSPLYSWREVEEKAYRGDLPHSQVYAFLVLRHGRSSYVNLQPAYVACSPAFVEKARENGLLVLGDDGATGATPLTVDLAEHLKERNRRVLSIAQFNIGGNTDFLALTEPERNLAKENTKSGFLKDILGYEPPHFIRPTGYLEPLGDKKFVSMHVQWVSFGGFTDELVVNMRINDSPALAGYIVDLARLAYALAKAGLRGTVPEVNRFYMKRPGPLDARHTSKIQAYREMLGLLEEKLGARLRAKPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U3</accession>
    <name>A1S0U3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753338.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1678"/>
    <dbReference type="EnsemblBacteria" id="ABL79073">
        <property type="protein sequence ID" value="ABL79073"/>
        <property type="gene ID" value="Tpen_1678"/>
    </dbReference>
    <dbReference type="GeneID" id="4600930"/>
    <dbReference type="KEGG" id="tpe:Tpen_1678"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_2"/>
    <dbReference type="OMA" id="WFAVLPN"/>
    <dbReference type="OrthoDB" id="34606at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="289" mass="32411" checksum="BF10FE3F11CA7CB9" modified="2007-02-06" version="1">MSTWSRLKASFVWSLKYLLRKQRVRFALFWVLFTIVLAAVGPLITPYDPTQTAGPPRQPPCSKYWLGTDWFGFDLFTRVVYGLRVSLYVGVIAAIVGTTVGVLLGLVSGYFGGLVDEIVSFVVNLLLTIPPLLIVILVLTYIGFRGLEFNGLLIGLLQWHWVARAVRSITKSLRSRDFVLVSRMSGLSAFETILNDILPNMLSYVALVFVLQFSSAVFFSVTLEFFGLVPGNIMSIGFILQQAVLWNAIQMNVWWWAIIPGILITLFLGSLYVISSSLDELFNPRLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1S117</accession>
    <name>A1S117_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753412.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1752"/>
    <dbReference type="EnsemblBacteria" id="ABL79147">
        <property type="protein sequence ID" value="ABL79147"/>
        <property type="gene ID" value="Tpen_1752"/>
    </dbReference>
    <dbReference type="GeneID" id="4601950"/>
    <dbReference type="KEGG" id="tpe:Tpen_1752"/>
    <dbReference type="HOGENOM" id="CLU_1109550_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="250" mass="26780" checksum="27114E3B197F5E1C" modified="2007-02-06" version="1">MRRSVGLASSLKKTVRHELFVSGKVAAATSLLAVGFSFLQFFLVLAYASSRGLAGGPPFSYFPLMLMSYAYGFLVLMGLSSLAGELKGSAALYLSQPLSRSEYVASWALAVVVSPLASLVASALFSAAVVDPALLWEHDPSLYAFWVLENMISGLLLLLVALLGRSSALLVVTWLVQRVAAPFVTLFLASLSRIQGRALNPLLEFLAQSVYPFTLYYSLNPQPHAVAGSAVLVATLAVAVYLVTSRRLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S138</accession>
    <name>A1S138_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753433.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1773"/>
    <dbReference type="EnsemblBacteria" id="ABL79168">
        <property type="protein sequence ID" value="ABL79168"/>
        <property type="gene ID" value="Tpen_1773"/>
    </dbReference>
    <dbReference type="GeneID" id="4601934"/>
    <dbReference type="KEGG" id="tpe:Tpen_1773"/>
    <dbReference type="eggNOG" id="arCOG05401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674078_0_0_2"/>
    <dbReference type="OrthoDB" id="106445at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="157" mass="17126" checksum="3BC40966BB9496CC" modified="2007-02-06" version="1">MPEASTKNVLLRGVDGEAYGELSRAAKRMGVSVGYLASQAFKVFLALLDAGPQLAGFKGDLPGFIGRALAVEKRRKPVFIRHVGRLVLSREDLEKVDGSLFIFGVGELVFDPSVDTKLFEEKVLRIVDCGKVVIHRGLDKLAVLSKSLFIGEIQEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S152</accession>
    <name>A1S152_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S16, lon domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753447.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1787"/>
    <dbReference type="EnsemblBacteria" id="ABL79182">
        <property type="protein sequence ID" value="ABL79182"/>
        <property type="gene ID" value="Tpen_1787"/>
    </dbReference>
    <dbReference type="GeneID" id="4601931"/>
    <dbReference type="KEGG" id="tpe:Tpen_1787"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027628_0_0_2"/>
    <dbReference type="OrthoDB" id="80994at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="49"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="628" mass="67296" checksum="CD068D7DBAE1EEB0" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S165</accession>
    <name>A1S165_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent protease La</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753460.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1800"/>
    <dbReference type="EnsemblBacteria" id="ABL79195">
        <property type="protein sequence ID" value="ABL79195"/>
        <property type="gene ID" value="Tpen_1800"/>
    </dbReference>
    <dbReference type="GeneID" id="4601793"/>
    <dbReference type="KEGG" id="tpe:Tpen_1800"/>
    <dbReference type="eggNOG" id="arCOG02163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023021_1_1_2"/>
    <dbReference type="OMA" id="GMIGVFR"/>
    <dbReference type="OrthoDB" id="43369at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014061">
        <property type="entry name" value="BrxL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13337">
        <property type="entry name" value="Lon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02688">
        <property type="entry name" value="TIGR02688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="469" mass="52988" checksum="910C91E17CEB5FD9" modified="2007-02-06" version="1">MAGSLDEKVKSIFGMVAINKAVANNVAISRVPRFISEYLINFKCGESQDAECVSRLSRYISELYPDPSDRELFLSRLKERGSLKLLDEFKVRVDLKRNTYLLEIPSLQIADAFVNEDIVRENARLFSGLWGVGLLYYKPELSRSKNRTPVVLHDYRPFQASYVDLKLFVESRSKFTFEEWVDLLVTSIGLNPKAYTLGQRLLLLSRLIPVAEPNVNILELGPRATGKTSLYRNVAYYSRIYAGGTITPARLFFDARLSVPGDLALHDVIVFDEISRVRLSNPDELVAKLKDYMVDGFFERGALKRAHSTCSLVFLGNVDVERIADPSHILEYLPSFMRDSAFLDRIHGFIPGWRLPKIMRSEESLASGYGLASDYLAEVLHRLRDVAAESVVADHVEFVGKYTIRDEKAVKRLLSGAVKILFPNFEFDNAELARVARGIVGLRNNVSRLLTAISPSEFPPKKLEVKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S178</accession>
    <name>A1S178_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_1813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1813"/>
    <dbReference type="EnsemblBacteria" id="ABL79208">
        <property type="protein sequence ID" value="ABL79208"/>
        <property type="gene ID" value="Tpen_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1813"/>
    <dbReference type="eggNOG" id="arCOG01952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_2"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="OrthoDB" id="52427at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL79208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="366" mass="39739" checksum="012E316BE088FA64" modified="2007-02-06" version="1">MGRCVFRASGRNVKAKVWRVDPSEPDAKSIEEAASILRKGGVVAFPTETVYGLGAVYHMRDAVIRVFKVKRRPPDNPLILHISSFSQIYTLASEVPEAVHRLAEKFWPGPLTVVLPKTSRVPYEVTGGLEKVAVRMPAHNVALRLIEAVGDPIAAPSANLSGRPSPTTAQHVLADLGDEIDGVLDAGETLYGVESTVIDLTADPPVLLRPGAVPLEEVEKVLGKVCVPAFARGLGEAERALAPGTRYRHYSPRAQLVLVELKDYSDLSKLVDRVKRLVAENAGRGLRVGVLCTDETREHYSGLGAVVLSLGSRRDPFGIARRLYSSFREMDSLGVDVIVAEGVDERGLGLTIMNRMRKASTKRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1S181</accession>
    <name>A1S181_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753476.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1816"/>
    <dbReference type="EnsemblBacteria" id="ABL79211">
        <property type="protein sequence ID" value="ABL79211"/>
        <property type="gene ID" value="Tpen_1816"/>
    </dbReference>
    <dbReference type="GeneID" id="4602053"/>
    <dbReference type="KEGG" id="tpe:Tpen_1816"/>
    <dbReference type="eggNOG" id="arCOG01500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_2_2"/>
    <dbReference type="OMA" id="ARCIGCY"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="131" mass="13854" checksum="9D43E33718BC8C32" modified="2007-02-06" version="1">MPRLVIVDVDKCVGCMSCMFACSRRFGEGGLAKSAIHVSSIGGVERGFKVVVCRACENPPCAAVCPTNALVRREGGGVVLNPSKCVGCGNCARACPIGAVQWDYESMKPIICVHCGYCVNYCPYGVLSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B2</accession>
    <name>A1S1B2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1847"/>
    <dbReference type="EnsemblBacteria" id="ABL79242">
        <property type="protein sequence ID" value="ABL79242"/>
        <property type="gene ID" value="Tpen_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1847"/>
    <dbReference type="HOGENOM" id="CLU_1954778_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="128" mass="14455" checksum="38CA36B93A93B45A" modified="2007-02-06" version="1">MKCPRGEAYVEPEHVSVTVRRDNTVTEQAFFRSEDGWLLKVAGDRLFNADTSLSDVLSSIGLYDEPREALESMGFDVDEVEPVVTRVESVESPEELYGMARRAYNKWRSSKAYVESGELAFTLPRGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F0</accession>
    <name>A1S1F0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751405.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1885"/>
    <dbReference type="EnsemblBacteria" id="ABL79280">
        <property type="protein sequence ID" value="ABL79280"/>
        <property type="gene ID" value="Tpen_1885"/>
    </dbReference>
    <dbReference type="GeneID" id="4600319"/>
    <dbReference type="KEGG" id="tpe:Tpen_1885"/>
    <dbReference type="HOGENOM" id="CLU_2839562_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="65" mass="7335" checksum="43FC5529B19C3479" modified="2007-02-06" version="1">MPVPEYIIRKTEAKYPVKYCEFAARIFPGLNVDRCRAGMAQIVGQKWAPNWESGLKAFFVSIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW51</accession>
    <name>A1RW51_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751696.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0021"/>
    <dbReference type="EnsemblBacteria" id="ABL77431">
        <property type="protein sequence ID" value="ABL77431"/>
        <property type="gene ID" value="Tpen_0021"/>
    </dbReference>
    <dbReference type="GeneID" id="4600487"/>
    <dbReference type="KEGG" id="tpe:Tpen_0021"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="RELWHKY"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="25675" checksum="1DA9EFF9396511A5" modified="2007-02-06" version="1">MTRAVFFDMGGVLVFDRGFAHHLARNVSLALREAGLEYSEEEVLRAWKESSVHGDELETWDLVRSMVLLRKLGVTPKPLLAEKVYKAVLESYVQGFSLDEEAEHALSLSRSLGFTVGLITNVGSYEIVRRRLEEAGLLKYVDVIVASQAVAWKKPSPRIFELACYLAGVEPGNAVHVGDDPRIDVEGAKKAGLRAVQVLKAGPPRSPYADAWVNSVGEVPGILEDWVSKGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW75</accession>
    <name>A1RW75_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein involved in formate dehydrogenase formation-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751720.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0045"/>
    <dbReference type="EnsemblBacteria" id="ABL77455">
        <property type="protein sequence ID" value="ABL77455"/>
        <property type="gene ID" value="Tpen_0045"/>
    </dbReference>
    <dbReference type="GeneID" id="4600933"/>
    <dbReference type="KEGG" id="tpe:Tpen_0045"/>
    <dbReference type="eggNOG" id="arCOG05634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071015_1_1_2"/>
    <dbReference type="OrthoDB" id="95915at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16341">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PTHR37689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="277" mass="30792" checksum="C37CB0C121747749" modified="2007-02-06" version="1">MSKGNLKEKLKEIQKDIPIEEGSLATYVGLIEVQEEAKGFYAEKFRDIDVEKVQEGFKEGKPAFLSLPLEISEEDIEKAYAAVTGYLSESLPETREPIARIEESRKTGELRLKELSDALFAGDEEHVHGVAERVGVDPEILEAVIAWSLQPIFQALSDAVSSKVDFSTWTSGRCPVCGGPTKLEYVDAGGHAHLRCQFCGTEWGYPEGKCPYCGNSDRKTVVEIPVKGEDKFKLMVCYKCGGYWKVVDERVVGGGVPRELYDIWSFRLDLLATGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW79</accession>
    <name>A1RW79_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751724.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0049"/>
    <dbReference type="EnsemblBacteria" id="ABL77459">
        <property type="protein sequence ID" value="ABL77459"/>
        <property type="gene ID" value="Tpen_0049"/>
    </dbReference>
    <dbReference type="GeneID" id="4600786"/>
    <dbReference type="KEGG" id="tpe:Tpen_0049"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_3_0_2"/>
    <dbReference type="OMA" id="INWSEYI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="77" mass="9198" checksum="B2640BC1C7881BBE" modified="2007-02-06" version="1">MAVITVRIDEETKRLMESVKINWSEFIRRAIREKIAEERRKNLAKAVLINERVRKRSRGEEKAEDIVRRFRDARSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA5</accession>
    <name>A1RWA5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0075"/>
    <dbReference type="EnsemblBacteria" id="ABL77485">
        <property type="protein sequence ID" value="ABL77485"/>
        <property type="gene ID" value="Tpen_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0075"/>
    <dbReference type="eggNOG" id="arCOG15079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2476202_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="87" mass="10075" checksum="31FFFAB5A8BF8FF7" modified="2007-02-06" version="1">MRIEEAIKTVEKTLREKGYSVTREVEDGDQVLVVQLGDRKAKVRFHGEAGELLELHLKYENVPGVTILKCERYLESMRCIEDLLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF5</accession>
    <name>A1RWF5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA wyosine derivatives biosynthesis protein Taw3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">taw3</name>
        <name evidence="7" type="ordered locus">Tpen_0125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751800.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0125"/>
    <dbReference type="EnsemblBacteria" id="ABL77535">
        <property type="protein sequence ID" value="ABL77535"/>
        <property type="gene ID" value="Tpen_0125"/>
    </dbReference>
    <dbReference type="GeneID" id="4602187"/>
    <dbReference type="KEGG" id="tpe:Tpen_0125"/>
    <dbReference type="eggNOG" id="arCOG04156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_2_2_2"/>
    <dbReference type="OMA" id="GKWHHYA"/>
    <dbReference type="OrthoDB" id="118297at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00266">
        <property type="entry name" value="TYW3_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022908">
        <property type="entry name" value="Taw3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSF111278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TYW3" evidence="6">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="22707" checksum="EC9DEB41448743EA" modified="2007-02-06" version="1">MSFHARSSAGGDPWEYLRRKALEQFERHLEEGRVDEDIVDLLRLVNNTKNCYTTSSCSGRIQVSCGEHPGAKGRLVVVAKWHRTVSLQELVSVLDSLQEESVWLSVHPPIFHVVARDLSVARKLLAGARNSGFKHSGIQGLGRRVVVEIMSMERLEVPIRVQGVEVVRRESLPILLETANEFLLRGKSRLGVLRKVFTEACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG6</accession>
    <name>A1RWG6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">Tpen_0136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751811.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0136"/>
    <dbReference type="EnsemblBacteria" id="ABL77546">
        <property type="protein sequence ID" value="ABL77546"/>
        <property type="gene ID" value="Tpen_0136"/>
    </dbReference>
    <dbReference type="GeneID" id="4602179"/>
    <dbReference type="KEGG" id="tpe:Tpen_0136"/>
    <dbReference type="eggNOG" id="arCOG01711">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_0_2"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="103587at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="177" mass="20088" checksum="71A5BEAC5D240FFD" modified="2007-02-06" version="1">MGIDIPPGKNPPEDIYVVIEIPMGSNVKYEIDKESGMVFVDRVLFTSMVFPFNYGFIPGTLEEDGDPVDVVLLSHDPFVPGSVVRARPVALLEMEDENGPDSKVVAVPHEKIDNRFSGVKDVDDIDDAVKDRIKHFFEHYKELEKGKWVKVKEWKGRFAAEESIRRAVERFKSKSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG7</accession>
    <name>A1RWG7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation elongation factor 1A GTP binding domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0137"/>
    <dbReference type="EnsemblBacteria" id="ABL77547">
        <property type="protein sequence ID" value="ABL77547"/>
        <property type="gene ID" value="Tpen_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0137"/>
    <dbReference type="eggNOG" id="arCOG01562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012821_2_0_2"/>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="21155at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039263">
        <property type="entry name" value="GTPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="PTHR43721:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="110"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="524" mass="58134" checksum="8457BEF6B6B8818C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI6</accession>
    <name>A1RWI6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751831.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0156"/>
    <dbReference type="EnsemblBacteria" id="ABL77566">
        <property type="protein sequence ID" value="ABL77566"/>
        <property type="gene ID" value="Tpen_0156"/>
    </dbReference>
    <dbReference type="GeneID" id="4601265"/>
    <dbReference type="KEGG" id="tpe:Tpen_0156"/>
    <dbReference type="eggNOG" id="arCOG02705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_2"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="OrthoDB" id="21634at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="261"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="513" mass="56445" checksum="E887144AE43AD202" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI7</accession>
    <name>A1RWI7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751832.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0157"/>
    <dbReference type="EnsemblBacteria" id="ABL77567">
        <property type="protein sequence ID" value="ABL77567"/>
        <property type="gene ID" value="Tpen_0157"/>
    </dbReference>
    <dbReference type="GeneID" id="4601266"/>
    <dbReference type="KEGG" id="tpe:Tpen_0157"/>
    <dbReference type="eggNOG" id="arCOG05808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438181_0_0_2"/>
    <dbReference type="OrthoDB" id="115257at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="188" mass="20178" checksum="54DA9A25AC100E3A" modified="2007-02-06" version="1">MTIVIRSANRTFLSPSPLSSIDKYLHAAANIISFNPLIAPAFEVRGGALELQLHERVTYAVTGDATVLADGEQAETWRAGVAQRSLEVKATGTAYVSIKGLQVSSVEPAQVRPGLSLAAVNPDSVPPKVLQAVKIPAGLKYPQNDWLESVSRLQRHVALVADAVQRGAELVKVKVGGSEYEVWVLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK2</accession>
    <name>A1RWK2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751847.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0172"/>
    <dbReference type="EnsemblBacteria" id="ABL77582">
        <property type="protein sequence ID" value="ABL77582"/>
        <property type="gene ID" value="Tpen_0172"/>
    </dbReference>
    <dbReference type="GeneID" id="4601427"/>
    <dbReference type="KEGG" id="tpe:Tpen_0172"/>
    <dbReference type="eggNOG" id="arCOG00863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_2"/>
    <dbReference type="OMA" id="QPMDVAG"/>
    <dbReference type="OrthoDB" id="77437at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="307" mass="33017" checksum="F54D99ECFF63B962" modified="2007-02-06" version="1">MSKDLVVLALGGNALLRTGERGTFEEQVRNLQRVSGHIARLASRYKLVITHGNGPQVGNLYLQQEAFKEVPGMPLHACVAMTQSLIGYMVQQAVSSVDPSLKVAVLTTRVEVDAEDPAFKSPSKPIGPYYQESEVPRLLEKGWTLVNVPGKGWRRVVPSPRPKRIVELEVVKRLAGEVDIVVAVGGGGIPVVRSGKGYEGVDAVIDKDLASSLLAQELNAEKFVILTDVEGVYLDYGTPSQRLVEELCAREALELVNKGVFPRGSMGPKVEAAALYAAKTGKVAVIAHLDRMLEAVEGGSGTRVLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM3</accession>
    <name>A1RWM3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751868.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77603">
        <property type="protein sequence ID" value="ABL77603"/>
        <property type="gene ID" value="Tpen_0193"/>
    </dbReference>
    <dbReference type="GeneID" id="4600802"/>
    <dbReference type="KEGG" id="tpe:Tpen_0193"/>
    <dbReference type="eggNOG" id="arCOG07465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1821113_0_0_2"/>
    <dbReference type="OMA" id="SWIFAGR"/>
    <dbReference type="OrthoDB" id="137945at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="141" mass="15870" checksum="2F1A808B7D95B831" modified="2007-02-06" version="1">MERRVARWSQLFITVLELAIAIILGVAVLLSLYKLASEAVKIAVTATFDRQHFVTFLDESLLMIVSIDLMRTLVGGIVEKRISVIIVLEAALIFIVREIITMELKAVSETRLLLYVVVFAALFISWIFAGRQAKVYGQDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN3</accession>
    <name>A1RWN3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751878.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0203"/>
    <dbReference type="EnsemblBacteria" id="ABL77613">
        <property type="protein sequence ID" value="ABL77613"/>
        <property type="gene ID" value="Tpen_0203"/>
    </dbReference>
    <dbReference type="GeneID" id="4602214"/>
    <dbReference type="KEGG" id="tpe:Tpen_0203"/>
    <dbReference type="eggNOG" id="arCOG00899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762117_0_0_2"/>
    <dbReference type="OMA" id="YRGATYW"/>
    <dbReference type="OrthoDB" id="89648at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="363" mass="40458" checksum="2C4156C079ADCDE1" modified="2007-02-06" version="1">MKLGKRALVILLEVLVVLLVFVYTLYGFDVVSFIEALRNVDAWDILPIVVFELAYYFSHAAAFWLLCRKRFSISMWEALGGSMLAWLVDILLPGAFVEGDIARAIFLKTKSDWPSAVSYTIFFRFLINVTMVVFIVFTSLLAINLLKFYEEYLVLYLGIVVATLLASLLLVLVLTKPLLVKNVAVFLARKAKVKRLEKFEKDLENFLSLVAEASRDFNFRNIHLWGAVAFLFLQWVSGILTPFFSLRAVGANVNLALIGPGYTILTLYSLASIGIPFMVGSIDAALLSLYLLLGVPREKALAATIIGRSVTILTSLLVIYPIGMFFAKKVFSSRNISVLKESIKRAAAEYGFAYTFSESSSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP5</accession>
    <name>A1RWP5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0215"/>
    <dbReference type="EnsemblBacteria" id="ABL77625">
        <property type="protein sequence ID" value="ABL77625"/>
        <property type="gene ID" value="Tpen_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0215"/>
    <dbReference type="eggNOG" id="arCOG02197">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500356_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="178" mass="19656" checksum="6C2A5AFECE3E2C6A" modified="2007-02-06" version="1">MVAMMVEFGVKGERVVVRVACLKSKSAVCPKDLVRSIQGRLPENVWVTLFDECRKIPPLEVVVSAVGYTVRGIMEGKTISRDPSLDVLLYVNGSRNIGEALKAFFSSCTESFGVVAFSLGREPRETAEALALFRELGFEESEPDLLGSLNFYSQRLGVPAEKVPGYMRARMVYLALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV1</accession>
    <name>A1RWV1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein archease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0271"/>
    <dbReference type="EnsemblBacteria" id="ABL77681">
        <property type="protein sequence ID" value="ABL77681"/>
        <property type="gene ID" value="Tpen_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0271"/>
    <dbReference type="eggNOG" id="arCOG04055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_2"/>
    <dbReference type="OMA" id="WLSELLY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01222">
        <property type="entry name" value="Archease_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022952">
        <property type="entry name" value="Archease_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="7">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="165" mass="18570" checksum="AC7C83C4F1BDC4BF" modified="2007-02-06" version="1">MRAMQKRLSPAVKKGVVEGMSGTCGGFELLPHTADIMVRAKGRSIEEAFSNAAVGMYEVMTSVASIEPLEDREVVAEGFDLENLLYNFLENLLVLLDTEGFLVSRVKSLRISKTEEGYRLTAVVSGERFSPDKHESRVLVKAITYHEMRIYREDNCYVVEYVPDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX6</accession>
    <name>RL40_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl40e</name>
        <name type="ordered locus">Tpen_0296</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751971.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWX6"/>
    <dbReference type="SMR" id="A1RWX6"/>
    <dbReference type="STRING" id="368408.Tpen_0296"/>
    <dbReference type="EnsemblBacteria" id="ABL77706">
        <property type="protein sequence ID" value="ABL77706"/>
        <property type="gene ID" value="Tpen_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="4601305"/>
    <dbReference type="KEGG" id="tpe:Tpen_0296"/>
    <dbReference type="eggNOG" id="arCOG04049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175093_1_0_2"/>
    <dbReference type="OMA" id="FQYKICR"/>
    <dbReference type="OrthoDB" id="127293at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00788">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_L40e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="PTHR39649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000046895" description="50S ribosomal protein L40e">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00788"/>
        </source>
    </evidence>
    <sequence length="51" mass="6347" checksum="0F802585F6CD5B94" modified="2007-02-06" version="1">MPIRDPEKLQLALEHHFKVKICRRCNARNPWNAERCRRCKSRDLRPKRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX7</accession>
    <name>A1RWX7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751972.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0297"/>
    <dbReference type="EnsemblBacteria" id="ABL77707">
        <property type="protein sequence ID" value="ABL77707"/>
        <property type="gene ID" value="Tpen_0297"/>
    </dbReference>
    <dbReference type="GeneID" id="4601117"/>
    <dbReference type="KEGG" id="tpe:Tpen_0297"/>
    <dbReference type="eggNOG" id="arCOG05330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194224_0_0_2"/>
    <dbReference type="OrthoDB" id="121194at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="71" mass="8276" checksum="9FCE7757CA70696D" modified="2007-02-06" version="1">MGRVSKGVECSIKGCSGQAERSISRDIFEKSKVGLELKEGVGDRVYLCKTHYKEFKKSYRKNVWRIERFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY5</accession>
    <name>A1RWY5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0305"/>
    <dbReference type="EnsemblBacteria" id="ABL77715">
        <property type="protein sequence ID" value="ABL77715"/>
        <property type="gene ID" value="Tpen_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0305"/>
    <dbReference type="eggNOG" id="arCOG00980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073526_1_0_2"/>
    <dbReference type="OMA" id="IREFHRH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="263" mass="29301" checksum="1EC99520C0E4778F" modified="2007-02-06" version="1">MGLQKGDFVLVNYTISVLEESGERVIDTTIKEEAEKAGFRTENVAFEPELVVVGEGFLLKPVEEKLVEMNEGEKREIVLEPSQAFGERDPKNIRVIPARELSSRGIIPRVGEEIELDGKRGKIIKIGAGRVTIDFNHPFAGKKVKVVLSLEKVLKNEEEKIKVLFRRWFRGIPQDKVNVTKGDGAVRIEVPPSIFLFENSFNLLSGFVRDVEKYFGDIASIELVEKIQLERGEKKEGEAASEATTASGETSSQEAKAEEKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ2</accession>
    <name>A1RWZ2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moaC</name>
        <name evidence="5" type="ordered locus">Tpen_0313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751987.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0313"/>
    <dbReference type="EnsemblBacteria" id="ABL77722">
        <property type="protein sequence ID" value="ABL77722"/>
        <property type="gene ID" value="Tpen_0313"/>
    </dbReference>
    <dbReference type="GeneID" id="4602081"/>
    <dbReference type="KEGG" id="tpe:Tpen_0313"/>
    <dbReference type="eggNOG" id="arCOG01530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_2_2"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="OrthoDB" id="104538at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01419">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_A">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023047">
        <property type="entry name" value="Mo_CF_biosynth-C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="4">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="150" mass="16910" checksum="555CCBB92C89AC7D" modified="2007-02-06" version="1">MMSVNVRMVDITGKAESERLAVAEGKIRLRRETIEKIRRGEVPKGDVLAVAKTAAIMAVKKTWEIIPLCHPIPITFVDVNFDVMEEELRVRVEVKTTAKTGVEMEALTGASVALLTVWDMVKSLEKDQEGQYPYTEINSIRVVEKVKRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX14</accession>
    <name>A1RX14_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752009.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0335"/>
    <dbReference type="EnsemblBacteria" id="ABL77744">
        <property type="protein sequence ID" value="ABL77744"/>
        <property type="gene ID" value="Tpen_0335"/>
    </dbReference>
    <dbReference type="GeneID" id="4601702"/>
    <dbReference type="KEGG" id="tpe:Tpen_0335"/>
    <dbReference type="eggNOG" id="arCOG04889">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002707_0_2_2"/>
    <dbReference type="OMA" id="TNAGHIT"/>
    <dbReference type="OrthoDB" id="5218at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="639" mass="72104" checksum="42B5B1E71D3094B7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX24</accession>
    <name>A1RX24_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0345"/>
    <dbReference type="EnsemblBacteria" id="ABL77754">
        <property type="protein sequence ID" value="ABL77754"/>
        <property type="gene ID" value="Tpen_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0345"/>
    <dbReference type="eggNOG" id="arCOG14993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217188_0_0_2"/>
    <dbReference type="OrthoDB" id="138973at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="106" mass="11681" checksum="3D394D3E63129ACE" modified="2007-02-06" version="1">MQLIEDVALNEQLPEDARKALLKALKLLSQAEDSLVEVKSQVRDITYTLQELAQSLGLDVKLSNPRLSIDSGEVLDLIEKSAVAELEIEDEKAVVKKLVTQQAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX29</accession>
    <name>A1RX29_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0350"/>
    <dbReference type="EnsemblBacteria" id="ABL77759">
        <property type="protein sequence ID" value="ABL77759"/>
        <property type="gene ID" value="Tpen_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0350"/>
    <dbReference type="eggNOG" id="arCOG04271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150448_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="15752" checksum="8EB83A8C392DEA0E" modified="2007-02-06" version="1">MQLLCSCSYAFPFPVHAKYLRRNVMARLMRGVVRSVGRLGYALVERVGIAGDGVEVEVEIPVRVLREAGLGLREGVEVVFEVAREAGSIDEWSVVMQGEVYLKKEGESAVYASLGGLQLVVKSPKIYNEFNVGDKVYFKLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX35</accession>
    <name>A1RX35_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="1">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgtA</name>
        <name evidence="3" type="ordered locus">Tpen_0356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752030.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0356"/>
    <dbReference type="EnsemblBacteria" id="ABL77765">
        <property type="protein sequence ID" value="ABL77765"/>
        <property type="gene ID" value="Tpen_0356"/>
    </dbReference>
    <dbReference type="GeneID" id="4600894"/>
    <dbReference type="KEGG" id="tpe:Tpen_0356"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OMA" id="FPCSCPV"/>
    <dbReference type="OrthoDB" id="10236at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="2">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="543" mass="61177" checksum="74DAA1BC1FFD32D4" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX57</accession>
    <name>A1RX57_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulatory protein Tpen_0378</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752052.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0378"/>
    <dbReference type="EnsemblBacteria" id="ABL77787">
        <property type="protein sequence ID" value="ABL77787"/>
        <property type="gene ID" value="Tpen_0378"/>
    </dbReference>
    <dbReference type="GeneID" id="4602146"/>
    <dbReference type="KEGG" id="tpe:Tpen_0378"/>
    <dbReference type="eggNOG" id="arCOG04152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_935744_0_0_2"/>
    <dbReference type="OrthoDB" id="105711at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00584">
        <property type="entry name" value="HTH_type_cro_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020886">
        <property type="entry name" value="Arc_TR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="33535" checksum="797923D2DECAC010" modified="2007-02-06" version="1">MTNKVVRFKSSEYCVDEVTVASKYILLEKRVKDAYQVTQYLAENLRVFSEFLEGLPLIIAESYKGEKIEEDVVYSRHNVPVVSSSTANSLLRGERKYLVYVSKGGVFVKLNGKELRKARERMGLSRGALAREVGVSARTIAYYEEGLSDATLEIAAKLEEILGSEIFEAISVDSLRELTKSGRPSVGSPAKRGRNVEWLISTLRDFVGERYFFDKAPLDAGFKVSLKTTSKFAIKAGISKEEEVQDVKELSEATETPVVILNNKEEILSEKVIVVDKRRPEKLRDYLSRIMENTRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX65</accession>
    <name>A1RX65_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0386"/>
    <dbReference type="EnsemblBacteria" id="ABL77795">
        <property type="protein sequence ID" value="ABL77795"/>
        <property type="gene ID" value="Tpen_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0386"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OMA" id="HYAYARS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="117"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="275" mass="29928" checksum="99E52B1CD53202C5" modified="2007-02-06" version="1">MLGLKYEVARVRSFPDGELYVRLPQGLKDEEVAYVVCYGRRPNEALAETVLAVEGLREKGAEKVVLVAPYLPYLRQDAEFTPGEVVSSRVIARLLAKLDVDALITVDPHLHRIRSLSELFPFPAIEVSAMPLLAAFFQKEHGTGVVVAPDEEAERWAKTFADTIGAPYFVFEKQRMGDEIVSVTGAVKRGETAVIVDDIVSTGGTLGEVAQKLLEAGFRDIYACVTHALLVQDAEARIFGSGVKEFISTDSVHNPYARVSVAGVIAEALKGVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX84</accession>
    <name>A1RX84_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt5</name>
        <name evidence="6" type="ordered locus">Tpen_0405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752079.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0405"/>
    <dbReference type="EnsemblBacteria" id="ABL77814">
        <property type="protein sequence ID" value="ABL77814"/>
        <property type="gene ID" value="Tpen_0405"/>
    </dbReference>
    <dbReference type="GeneID" id="4601499"/>
    <dbReference type="KEGG" id="tpe:Tpen_0405"/>
    <dbReference type="eggNOG" id="arCOG01920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OMA" id="FSEIEHF"/>
    <dbReference type="OrthoDB" id="91936at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="157" mass="17317" checksum="C7B68D82154085CF" modified="2007-02-06" version="1">MAEKPPSPLRFYALRVTSGQEYNVAQLLYRRAASGKYKVYSILVVPGLKGMVFVESDALYEAQRLAYGLKHVRGVVRGAVSLQEMEGLLKPKPLVDQLNVGDFVEIIRGPFTGMRGRIVGIDKSRNEVKVELAEAVFVLPVTINADDIKVIKRGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA0</accession>
    <name>A1RXA0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752095.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0421"/>
    <dbReference type="EnsemblBacteria" id="ABL77830">
        <property type="protein sequence ID" value="ABL77830"/>
        <property type="gene ID" value="Tpen_0421"/>
    </dbReference>
    <dbReference type="GeneID" id="4602100"/>
    <dbReference type="KEGG" id="tpe:Tpen_0421"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_1_2"/>
    <dbReference type="OMA" id="GYDVHMN"/>
    <dbReference type="OrthoDB" id="119206at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="PTHR10553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="73" mass="8102" checksum="10C2EB5A87A1DA23" modified="2007-02-06" version="1">MEEGTISVLAESLEKNVLVKLKGGREIRGQLKSYDYHLNLVLENAEEIRGTRTRQLGTIIVRGDNVILVSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB0</accession>
    <name>A1RXB0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ordered locus">Tpen_0431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752105.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0431"/>
    <dbReference type="EnsemblBacteria" id="ABL77840">
        <property type="protein sequence ID" value="ABL77840"/>
        <property type="gene ID" value="Tpen_0431"/>
    </dbReference>
    <dbReference type="GeneID" id="4602166"/>
    <dbReference type="KEGG" id="tpe:Tpen_0431"/>
    <dbReference type="eggNOG" id="arCOG04175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177460_0_0_2"/>
    <dbReference type="OMA" id="KRSMIRI"/>
    <dbReference type="OrthoDB" id="126595at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="9951" checksum="E91B24C50C83851D" modified="2007-02-06" version="1">MAQVKTFEVKGYMVLRYGERRKFTLYLRGLSEREVLESAYSLLGSRHKVTRNHIKVESVTEVPPENVKDNYVKELSRTDKIVVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXE7</accession>
    <name>A1RXE7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0468"/>
    <dbReference type="EnsemblBacteria" id="ABL77877">
        <property type="protein sequence ID" value="ABL77877"/>
        <property type="gene ID" value="Tpen_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0468"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="432" mass="49351" checksum="04930B555B9F98EA" modified="2007-02-06" version="1">MMGYEEIEKTVREETWRRAALSLYATRTEDKRRSRGKKKRGEIHYRGLYDTVSGINWDFTKFLVNGYSVVPDSVYPRFYRFIDYDLRKYLLLNDDEKPREGGAVMELKGRLQAIVDAGADGLRAEKKGKVWHVYIPRENWHVRVSKPTHGWSVHIPLEGFWVESEFPQVLVNTPSDVLRSLQKGWILTDVTPPHGRYSDVRFGTTQPWQLPATLATFPSDDARLGVTAGILGSTRLSFQWQVRVYGYEEELGWASTLIGATKRVEFRRLVEECKELNGDPASLFTTFLGDGYLAFFLRLRMLHFRIGSEVFYLPAESAIINARLAVERASEYTKFVSLVTKCAKIKHFLFVGFGLPRKKGRKNGQRNNPFYAEIAGAQLHLAYVSSTNNIYARIAVEAVPSGWVEEARAQGWDVRVVRMGGVGSTTRLHTPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXG7</accession>
    <name>RL22_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl22</name>
        <name type="ordered locus">Tpen_0489</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABL77897" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77897.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052885053.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXG7"/>
    <dbReference type="SMR" id="A1RXG7"/>
    <dbReference type="STRING" id="368408.Tpen_0489"/>
    <dbReference type="EnsemblBacteria" id="ABL77897">
        <property type="protein sequence ID" value="ABL77897"/>
        <property type="gene ID" value="Tpen_0489"/>
    </dbReference>
    <dbReference type="GeneID" id="4601787"/>
    <dbReference type="KEGG" id="tpe:Tpen_0489"/>
    <dbReference type="eggNOG" id="arCOG04098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OrthoDB" id="103467at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000354549" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="151" mass="17410" checksum="394AE12ED0D6B617" modified="2008-11-25" version="2">MPTWRYSVELEPERTAKASLRDVSMSYKLTVETLRLIKGKSIEEARRILTEIAEMKRSVPLKRYNKKVGHRSDVPGPGRYPVKVAKNLLKLLDNLENNAEFKGLNVENLRIVHAAAHKGMKIRNYLPRAFGRATPYYDQLVHVEIIAREVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI0</accession>
    <name>A1RXI0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0503"/>
    <dbReference type="EnsemblBacteria" id="ABL77910">
        <property type="protein sequence ID" value="ABL77910"/>
        <property type="gene ID" value="Tpen_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0503"/>
    <dbReference type="eggNOG" id="arCOG00509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_2"/>
    <dbReference type="OMA" id="VPWLHWP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="256"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="401" mass="45281" checksum="53E252ADA3F74927" modified="2007-02-06" version="1">MPRVFVDKVVDDLYVLRVDDDRTRFFEALWEIEEGITYNAYLLLTGEGAVVFDGWKKWFSELFLEKIREIVDYGDIRYVVVHHAEPDHSGSVPDVLRVSEKAVALGHPIAGRMLSSFYGVTRFRPVKDGEELKVGERSIHFVYTPWLHWPETIMSYLRDDGVLLSCDAFGSYSVPALYDESVENFEKLAWFIKKYYVTVIGHYSPHVLKALEKLGSLGVKPRIIAPSHGTIFRRNAERILDEYRRIALGEPVKGKAVVVYVSMYGFVERLVSLAIEELSQRGFETRVYAFTDTSRPRISDILGELADAELLVLGGATYEAGVQPVLDYVVRLIAEKLEYRSDKLAVLLLSSYGWAGTAGKLVAEALKGHGFQRVSSVEVQGYAPENVKENLKKALDSLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM4</accession>
    <name>A1RXM4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSU ribosomal protein S26E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752219.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0548"/>
    <dbReference type="EnsemblBacteria" id="ABL77954">
        <property type="protein sequence ID" value="ABL77954"/>
        <property type="gene ID" value="Tpen_0548"/>
    </dbReference>
    <dbReference type="GeneID" id="4600512"/>
    <dbReference type="KEGG" id="tpe:Tpen_0548"/>
    <dbReference type="eggNOG" id="arCOG04305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_3_0_2"/>
    <dbReference type="OMA" id="DKAICVT"/>
    <dbReference type="OrthoDB" id="117249at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_S26e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_S26e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="PTHR12538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="97" mass="11105" checksum="86E9536233771C33" modified="2007-02-06" version="1">MPKKRKSRGRHKGDKGKEDLVQCDECGALIPRSKAVKITKPVMPIDPQLAKELRDKGAILPQYTVTKYLCLRCAIHRGIIKIRPEEERKSQKINLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM8</accession>
    <name>A1RXM8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752223.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0552"/>
    <dbReference type="EnsemblBacteria" id="ABL77958">
        <property type="protein sequence ID" value="ABL77958"/>
        <property type="gene ID" value="Tpen_0552"/>
    </dbReference>
    <dbReference type="GeneID" id="4600516"/>
    <dbReference type="KEGG" id="tpe:Tpen_0552"/>
    <dbReference type="eggNOG" id="arCOG01679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441901_0_0_2"/>
    <dbReference type="OrthoDB" id="114275at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="619" mass="68433" checksum="FF9DB99619855EAA" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXQ2</accession>
    <name>A1RXQ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0577"/>
    <dbReference type="EnsemblBacteria" id="ABL77982">
        <property type="protein sequence ID" value="ABL77982"/>
        <property type="gene ID" value="Tpen_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0577"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OMA" id="MMVIEEQ"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="9286" checksum="1DF7B5BA2D949017" modified="2007-02-06" version="1">MHEQSQNIAYVLINCEIGKEKDVLEQIRNIPGVIEAHLLYGVYDIIVKVTGKDNVEIREMILTKIRRIPGVKRTLTMPVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR0</accession>
    <name>A1RXR0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0585"/>
    <dbReference type="EnsemblBacteria" id="ABL77990">
        <property type="protein sequence ID" value="ABL77990"/>
        <property type="gene ID" value="Tpen_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0585"/>
    <dbReference type="eggNOG" id="arCOG01225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OMA" id="METFLFH"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="270" mass="30171" checksum="5D7C5A1140C96035" modified="2007-02-06" version="1">MFREKVLKPRVSIVCVVRKSIIVMLGPAGSGKTSLVASLGKWIEKKQLVPVLYVNLDPGAPYTPYAAEVNIREYVKVEDVMAREKLGPNGALIRSIELAREYLPEIVERIGRSPKPYVLVDTPGQMELFLFRDLGVEFVEAMRRVGYIIGVLIFDHLLAARPQDVVSLRLLATIVQLRLGVDVIPVINKSDVSSETRERLSRALSDSSSLLEELKSERGLLGEMSEKVVGVLDEYRFATRVPLVSALTWEGLEELYDMLHEIFCACGDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR2</accession>
    <name>A1RXR2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">Tpen_0587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752257.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0587"/>
    <dbReference type="EnsemblBacteria" id="ABL77992">
        <property type="protein sequence ID" value="ABL77992"/>
        <property type="gene ID" value="Tpen_0587"/>
    </dbReference>
    <dbReference type="GeneID" id="4600629"/>
    <dbReference type="KEGG" id="tpe:Tpen_0587"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_3_0_2"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="33997at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="386" mass="44804" checksum="178A72A941866B2E" modified="2007-02-06" version="1">MSEGFREGDFSVTPWEAKGKIDYDKLIQEFGVEKLGEELLSRIERIAGGLHPLLRRNFFFAHRDLNLVLNDYEEGRGFFLYTGRAPSNSPMHIAHIVPFIATRWFQEKFGANVYIQIPDEEKFLAKKVETLEEIEKYAVQDILNIIALGFDENKTFIFRDTEYISKLYKPAVLVARHINFSTARAVFGFDNESTIGLIFYPALQIVPTFFEKKRPLIPCGIDQDPYFRLQRDIAPRLNRYKAAEVLSKLVWGLKGPETKMSASEPDTAILLSDPPETVKRKIINAYTGGRATVEEQRRLGGVPEVCTVFHWYSVLFEDDDKKLLERYHACRTGKLLCGECKAELVERINSFLERHRARVKDAEKKMHLYLYDGKLAQEMWNWEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT3</accession>
    <name>A1RXT3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ordered locus">Tpen_0608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752278.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0608"/>
    <dbReference type="EnsemblBacteria" id="ABL78013">
        <property type="protein sequence ID" value="ABL78013"/>
        <property type="gene ID" value="Tpen_0608"/>
    </dbReference>
    <dbReference type="GeneID" id="4601228"/>
    <dbReference type="KEGG" id="tpe:Tpen_0608"/>
    <dbReference type="eggNOG" id="arCOG04090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OMA" id="VFQDGIY"/>
    <dbReference type="OrthoDB" id="80629at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="191" mass="21038" checksum="CBC643C5C3C055D1" modified="2007-02-06" version="1">MRVLQKTESVPIPEGVKVHVNGKRVEVEGPLGKVEKDFSHARRISIRVEGNSVVVETFHATKKDYALVGTIASIINNMIIGVTKGYRYKLKIVYAHFPMSLKVEKDKIIIENFLGERGKRIAGIMPGAKVKIEKDDVIVEGIDLDAVAQTAANIHLATHLRGKRALSPHGREGTGPGILDGIYLYAIEHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU0</accession>
    <name>A1RXU0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Tpen_0616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752285.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0616"/>
    <dbReference type="EnsemblBacteria" id="ABL78020">
        <property type="protein sequence ID" value="ABL78020"/>
        <property type="gene ID" value="Tpen_0616"/>
    </dbReference>
    <dbReference type="GeneID" id="4601322"/>
    <dbReference type="KEGG" id="tpe:Tpen_0616"/>
    <dbReference type="eggNOG" id="arCOG01358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="18705at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="133"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="428" mass="48362" checksum="71B5D2997C76E64A" modified="2007-02-06" version="1">MARVYIETFGCWLNKGESNIMATLLKRRGHKVVESIENADVVILNTCAVRGDTETKIFRRLRELEELRQKRGFRLVVSGCLVNVRPKSILDVAPSASLVEPDAIEKIPEVVESEDKLLIVRQYKASRNVLPDYSGGAVHVVPIESGCLGSCAFCIEWVTRGTGVKSYPIDVIIENVRAAVSKGAREIFLTGQDVAAYGYDLGTNLYELVKRILEEVDGEYRVRLGMMEPMLLGRFLKNLLELFRDERLYRYFHIPAQSGDDKVLRLMRRKYTVEEYKGIVNTIRGSGWKFSIVTDIIVGFPGEGEAEFQNTLKFLREVMFDKVHVARYTFRPFTEGYVMSGVPEPVKKQRSRLASRVALEVAYEINRSYVGEEREVVVEGTSIRGDLVGRTIEYKPVVIKDQEARVGEIVRVKIVDATPVSLIGKVLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV1</accession>
    <name>RL34_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl34e</name>
        <name type="ordered locus">Tpen_0627</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXV1"/>
    <dbReference type="SMR" id="A1RXV1"/>
    <dbReference type="STRING" id="368408.Tpen_0627"/>
    <dbReference type="EnsemblBacteria" id="ABL78031">
        <property type="protein sequence ID" value="ABL78031"/>
        <property type="gene ID" value="Tpen_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0627"/>
    <dbReference type="eggNOG" id="arCOG04168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_2_0_2"/>
    <dbReference type="OMA" id="GAPRCPI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_L34Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_L34e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="PTHR10759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000133416" description="50S ribosomal protein L34e">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00349"/>
        </source>
    </evidence>
    <sequence length="91" mass="10407" checksum="E57B3BED0946D6AC" modified="2007-02-06" version="1">MPRPALRSRSKKRKLVRTPGGRLALHVIDKKHDYPKCAICGRPIQGVPKLTSRLERRGVRMPTRPYGGYLCHECLRKGIKLSVWMSASKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW1</accession>
    <name>A1RXW1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0638"/>
    <dbReference type="EnsemblBacteria" id="ABL78041">
        <property type="protein sequence ID" value="ABL78041"/>
        <property type="gene ID" value="Tpen_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0638"/>
    <dbReference type="eggNOG" id="arCOG00417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1307880_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="210" mass="23417" checksum="A27BA7F273C6A955" modified="2007-02-06" version="1">MGSPTPRGEKYGRLLRILSRSGLHVVYGEPGSLKTTFALLLAKSMKKERKVYVGLAKHAFLDFPSSFSKDFLVLRALSFKEEVAALLRLEQVSDENTVIVYDGFASLTSPLLTLGKSHPVLRANTFVAAKLYEVAEKSRCTVLIVTMPGLDSKPRFFSALRPYASEYTFLSRNGENLVVEVRDKDLNTVLRLSMDPGELLSQVYHKSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY02</accession>
    <name>A1RY02_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Methionine aminopeptidase</fullName>
            <shortName evidence="3">MAP</shortName>
            <shortName evidence="3">MetAP</shortName>
            <ecNumber evidence="3 4">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">map</name>
        <name evidence="6" type="ordered locus">Tpen_0680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3 4">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752347.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0680"/>
    <dbReference type="EnsemblBacteria" id="ABL78082">
        <property type="protein sequence ID" value="ABL78082"/>
        <property type="gene ID" value="Tpen_0680"/>
    </dbReference>
    <dbReference type="GeneID" id="4601880"/>
    <dbReference type="KEGG" id="tpe:Tpen_0680"/>
    <dbReference type="eggNOG" id="arCOG01001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_2"/>
    <dbReference type="OMA" id="NEIAAHY"/>
    <dbReference type="OrthoDB" id="82853at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="303" mass="33527" checksum="6890741F0FA21316" modified="2007-02-06" version="1">MAEQLKRAGDVAREALKLAVDISHEGVPLIEIAERVEEFIRSRGALPAFPVNLSINQVAAHYTPSSNDELRVPKGSVLKIDVGVHVDGYIADCAVTVVQSGEYRRLALAAFEALKSAALALKPRSTAYDVGKVVEGAIRKYGYKPIENLTGHKIERYNLHAGKSIPNVARYEYRLVGINIGEVYAVEPFATNGVGQVIDSGWSNIYRVVSVRRISREKDLNDVLEALWKEFKGLPFAERWVSRMGFSEKELRGLVESKRVYHYPRLVEAGGGLVSQFEDTFIVDQDSAKPIVGVIESFAELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY28</accession>
    <name>A1RY28_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PUA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752373.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0706"/>
    <dbReference type="EnsemblBacteria" id="ABL78108">
        <property type="protein sequence ID" value="ABL78108"/>
        <property type="gene ID" value="Tpen_0706"/>
    </dbReference>
    <dbReference type="GeneID" id="4601380"/>
    <dbReference type="KEGG" id="tpe:Tpen_0706"/>
    <dbReference type="eggNOG" id="arCOG00991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116577_2_0_2"/>
    <dbReference type="OMA" id="DYQFGRG"/>
    <dbReference type="OrthoDB" id="124540at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TGT_C2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="161" mass="18097" checksum="65ABA337A451B909" modified="2007-02-06" version="1">MEREKPSPWERKALQRLLLYQFGVDFDLERLGDKLSVERSRRTGRIRKIFVGDTLFASVRLSDGFIVPTPEGWRLLLSVRRCYFVEVPEDVARYVSQGRTVFSKHVIEADREILPGDEVAVISGEEARVSGSGKAMLPGDSMGVIRRGKAIKTRTGAGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY62</accession>
    <name>A1RY62_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752407.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0740"/>
    <dbReference type="EnsemblBacteria" id="ABL78142">
        <property type="protein sequence ID" value="ABL78142"/>
        <property type="gene ID" value="Tpen_0740"/>
    </dbReference>
    <dbReference type="GeneID" id="4601147"/>
    <dbReference type="KEGG" id="tpe:Tpen_0740"/>
    <dbReference type="eggNOG" id="arCOG01147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083277_0_0_2"/>
    <dbReference type="OMA" id="VIHGHAH"/>
    <dbReference type="OrthoDB" id="74374at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="238" mass="26179" checksum="450C2BA938D794B6" modified="2007-02-06" version="1">MRVLAFADTHAPKHVSLLAESLGRLRLEGVELVLVAGDVVARGEWAACRQVEAVLRRFLPGVPAYGTFGNEDFEEVRGRIREECTEVVWLEDEAVDVEVGGTRVRIVGTPGVLDRPTRWQERNVPGIRGVYEARLERVRELLSHPSGSLKILVTHYPPRCGTLRGEDPRFWEEMSSARLAGVVAGSGVDLVVHGHLHRSVVHRDYIGSTPVYNVSLPAVKSAVIIEVRRAGLGAFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY68</accession>
    <name>A1RY68_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0746"/>
    <dbReference type="EnsemblBacteria" id="ABL78148">
        <property type="protein sequence ID" value="ABL78148"/>
        <property type="gene ID" value="Tpen_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0746"/>
    <dbReference type="eggNOG" id="arCOG07315">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192667_0_0_2"/>
    <dbReference type="OrthoDB" id="136318at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="24255" checksum="DDA2230BBEC4DF25" modified="2007-02-06" version="1">MASVAGEYLEAVASFASLEELVRRAAGGVSLVVSLDGRLLPLASLLGRSTGGTPVVLTAARPGVERALREAARGRYLVVRGEMLAATPRSVFVYLARRGLVEPSLAVAEVAAAGAPSVAPNTSVKKAVSLLEESGAIAVGVRSRGRISKVLTVVDFAGYALEAGLSRRDLLLDPTPVSRVDPVVVGDPADLRSGFLDGVSRYSMAVVELGCEVLVDESSLRKYLAARVVTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY80</accession>
    <name>A1RY80_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0758"/>
    <dbReference type="EnsemblBacteria" id="ABL78160">
        <property type="protein sequence ID" value="ABL78160"/>
        <property type="gene ID" value="Tpen_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0758"/>
    <dbReference type="eggNOG" id="arCOG01145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653186_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="425" mass="48105" checksum="65C29C55A1A738DF" modified="2007-02-06" version="1">MSRVRFLAVSDVHGKEDLVDKFIEWVQRDSLPYDFVVAAGDMGNPQRPGSMCRILKKIASSLKKNVYYVKGNWDIEGSCGDPAVLDLDETGPLFFGNIVLVGHGRRAEPYDIPRANNVTVLVTHYPPYSILDRGKVIDSNHRSLHAGVVDINYLIDVYRPRVHIFGHSHSYGGLDVEHNGVVYVNVARLDRLLKNGESIGNYAVIDVGGSGDVRVEWRFINGTWKRCAGCGRVVHIPEKWALCRRCAHKSELKFTKITGVPYRARLVIKDPLTQKLVYSKEVRIPFYTLKDYQTLEEFVDAVVLREAKSFLSDGSSKVLELPKDKVLEFYNSSSAKRLTPFSEYLFACDESVSGSKLCLLMRVFSADKQAHVMWKISEEAETGRRLLEQYVLFKEEQASMLNFLVRRLSEAGFRVLAYSLEALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY97</accession>
    <name>A1RY97_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0775"/>
    <dbReference type="EnsemblBacteria" id="ABL78177">
        <property type="protein sequence ID" value="ABL78177"/>
        <property type="gene ID" value="Tpen_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0775"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792232_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="35"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="16922" checksum="AA333D13EA62E00F" modified="2007-02-06" version="1">MEEWIRREIEEMLREFKRVREEISRIEEEVFRPLAPEERVQVPLYEVRRSSDCLTIYADLAGVKRKEDVDVYVEGNVLRIEARLSKPLLFEGLVFFREGITKYKLEIPLPSNADVENIKASFRKGMLEVTVPLKVQRVRVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB2</accession>
    <name>A1RYB2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78192">
        <property type="protein sequence ID" value="ABL78192"/>
        <property type="gene ID" value="Tpen_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0790"/>
    <dbReference type="HOGENOM" id="CLU_203625_1_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="42" mass="4545" checksum="7636B704270642DD" modified="2007-02-06" version="1">MLDAIEEFLASVGSATPQVEEDKELARELEEDIEGLRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH5</accession>
    <name>A1RYH5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ordered locus">Tpen_0854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752520.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0854"/>
    <dbReference type="EnsemblBacteria" id="ABL78255">
        <property type="protein sequence ID" value="ABL78255"/>
        <property type="gene ID" value="Tpen_0854"/>
    </dbReference>
    <dbReference type="GeneID" id="4601979"/>
    <dbReference type="KEGG" id="tpe:Tpen_0854"/>
    <dbReference type="eggNOG" id="arCOG01304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069350_1_0_2"/>
    <dbReference type="OMA" id="RCSVDYA"/>
    <dbReference type="OrthoDB" id="96363at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="26722" checksum="959D6B18AF0DA404" modified="2007-02-06" version="1">MTVVEELRAAVSSKKLVVLVARCTVTYEGRASSKLEEGDRVILIKEDGSVIVHRPVGYEPVNYQPPGSVVSVEGDDDGFRIIVTRTKRRERLLIEVHSVKHFFSAKLEDSARFTMWGDEEDLRRAILADPSKMLGENLKPVGAEVSLGSAGFADAVFVDSEGNLVVVEVKREKASVEAVYQLKRYVERIKRETGRKVRGILAAPGFTVSAIRALKAEGLEYRQVSMKDAREVLSRLTAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI2</accession>
    <name>A1RYI2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0861"/>
    <dbReference type="EnsemblBacteria" id="ABL78262">
        <property type="protein sequence ID" value="ABL78262"/>
        <property type="gene ID" value="Tpen_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0861"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_2"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="64"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="265"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="744" mass="83110" checksum="7EDABF6EC3F2A977" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK2</accession>
    <name>A1RYK2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752547.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0881"/>
    <dbReference type="EnsemblBacteria" id="ABL78282">
        <property type="protein sequence ID" value="ABL78282"/>
        <property type="gene ID" value="Tpen_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="4600824"/>
    <dbReference type="KEGG" id="tpe:Tpen_0881"/>
    <dbReference type="eggNOG" id="arCOG00934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_2"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="OrthoDB" id="34153at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="157"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="374" mass="43448" checksum="6D258EF249A272A5" modified="2007-02-06" version="1">MRFREEYEYISLIRPDSVTVWEYPEVRERLSHYLGVLRGEKPARYRVARRMPVDYDEKAPLEELLDVHRSYSRDFEKVYAESVEKGLEKNLPSKSYLDLKIEIAKRMLRSCFFCEWRCMVNREEGKRGVCGLGKEVRVASAFLHVGEEAPLVPSGTIFFTGCSFKCVYCQNWDISTRVDNGEKVTPQELAGIATALYLRGARNINYVGGNPDQQLHVILESLRYMDVNVPLLWNSNMYMSQEALSLLLDVVDIWLPDFKYGNDDCARRLSGVPRYFEVVSRNHKVVCDAGRDIIIRHLVLPSHVECCTKPVLKWISENCPRALVNVMDQYRPEHLVARFPQRWPEIARRPTASEIREAYEYADRLGLAWRPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK5</accession>
    <name>A1RYK5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KH, type 1, domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0884"/>
    <dbReference type="EnsemblBacteria" id="ABL78285">
        <property type="protein sequence ID" value="ABL78285"/>
        <property type="gene ID" value="Tpen_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0884"/>
    <dbReference type="eggNOG" id="arCOG04325">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730800_0_0_2"/>
    <dbReference type="OMA" id="YLRGRTF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="378" mass="41647" checksum="0A495D1815F4DB92" modified="2007-02-06" version="1">MSLPFTPATEKQKMLLGALESPDVDLVGVFGPSGTGKSFVVLLYGLSAVRSGKYKRMVVVKPLVSLSRSKVLDSSEMGNLFFEIASSYVEDVAGDYVDLKELREMFDQRKVVFVDPDFLAGRTFDNSLVFLDDVQYASPDLVTECIIRTGKNSKLVIAGDPILQALEGKTRNTAAIARELLLGEERSLVINMGINDIVRPGSKRGFKLALESRLRRRALSEEEEKVKAILQSHAPDADVVTVVWLKDLKEKFGAHTAPDVLAVAKENTLSRLIGKKGERINKAQEEAGVQIRAVELTQDLGEIVKAIHPVGWIRKHITSVEIEGSELAVYVNPDEYGAFVGKQGSYIRFLDAAVRRLLGLGVRGKHAEKTEQRGAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYP9</accession>
    <name>A1RYP9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78329">
        <property type="protein sequence ID" value="ABL78329"/>
        <property type="gene ID" value="Tpen_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0928"/>
    <dbReference type="eggNOG" id="arCOG09700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387640_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="230" mass="25073" checksum="F9E86276B14A77F4" modified="2007-02-06" version="1">MDTRLLGNTARTYITLLCTRSGDGMEGLWVAVYVGYVALVNVYPEAAYLELLACSFFLLRGNSALTGSRLDGRAAVFLLVAPVAFQPLLYVRSVTLPSPLSLLFAVLASFSEEYFFRGFLLGVAGNPLQAYLFALSHLALSDPVYLVNSALLVPHYFLLGLVAGLLAERWGLLSSILFHAAYNACSIFLYVEYSLQALLLLVLLDAALLVATFLLTTCKKSILTARVLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ8</accession>
    <name>A1RYQ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HI0933 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752603.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0938"/>
    <dbReference type="EnsemblBacteria" id="ABL78338">
        <property type="protein sequence ID" value="ABL78338"/>
        <property type="gene ID" value="Tpen_0938"/>
    </dbReference>
    <dbReference type="GeneID" id="4601067"/>
    <dbReference type="KEGG" id="tpe:Tpen_0938"/>
    <dbReference type="eggNOG" id="arCOG01294">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_2_0_2"/>
    <dbReference type="OMA" id="GWCQGRM"/>
    <dbReference type="OrthoDB" id="48488at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="113"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="469" mass="50371" checksum="AD5A044A325B1FF4" modified="2007-02-06" version="1">MRITEHPILEFRRGSPVKFRFDGEEVEAFEGESIAAALWASGIRDFRRGEQGPQGPFCMIGYCSGCMVRVDGRSRVRACLEPVRDGAVVEREDKPLPSGVVGEAGEAGELDVDVMVIGSGPAGLSAALASASAGLEVHVFERHFRPGGQLVKQTHKFFGSGELFGGLRGFQIAERLVSEAERAGVKIHTRSPVLGWFGEGVFAVNEGGRLLRVRAKAVVVGTGAVERFLPFPGNTLPGVMGAGAAQTLMNEYGVKPGEKAVVVGAGNVGLIVSYQLLQAGVSVEAVVEVRPEIGGWFVHAAKLRRLGVPILTEHTVVRAEGRGRVERVVISRVGKDFQPLKEYERSVEADLLLLAVGLTPESRLLAEMGARMTWSTELGGYVPYRDRYMETSIPGVYVAGDASGIEEATTALLTGRVAGLSAAIRILGERGELVEEREKALRMLDETRRTPFSARVVEGIRRVSVGVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU3</accession>
    <name>A1RYU3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron dependent repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752638.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0973"/>
    <dbReference type="EnsemblBacteria" id="ABL78373">
        <property type="protein sequence ID" value="ABL78373"/>
        <property type="gene ID" value="Tpen_0973"/>
    </dbReference>
    <dbReference type="GeneID" id="4600447"/>
    <dbReference type="KEGG" id="tpe:Tpen_0973"/>
    <dbReference type="eggNOG" id="arCOG02100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_3_0_2"/>
    <dbReference type="OMA" id="ACLMEHA"/>
    <dbReference type="OrthoDB" id="110491at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="148" mass="17339" checksum="3BF08D1450E06A42" modified="2007-02-06" version="1">MKTLVSRRSEDYLRVIYEIAEAKGYVRIKDISRALGVKPSTAVEMVRKLHELGLVDYKKYEGITLTARGKEIAEAVKKRRDIFENFLKIILVPENVAKRDAHILEHQLSPETVLQIARFVEFASQAKEWIDEFRNYCEMIKRLDKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX6</accession>
    <name>A1RYX6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752671.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="SMR" id="A1RYX6"/>
    <dbReference type="STRING" id="368408.Tpen_1006"/>
    <dbReference type="EnsemblBacteria" id="ABL78406">
        <property type="protein sequence ID" value="ABL78406"/>
        <property type="gene ID" value="Tpen_1006"/>
    </dbReference>
    <dbReference type="GeneID" id="4600679"/>
    <dbReference type="KEGG" id="tpe:Tpen_1006"/>
    <dbReference type="eggNOG" id="arCOG00984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_2"/>
    <dbReference type="OMA" id="CTMALNG"/>
    <dbReference type="OrthoDB" id="22099at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="377" mass="41019" checksum="102E8388485B8CAD" modified="2007-02-06" version="1">MSAGLRFTHKHPTTVVFERGSLNRLGELVKGLGGKALVVTGRQFAKKYGYDSLIKSQLESAGVEVYFFSEVEPNPTIETADRCAEAARKAGVDFFVAFGGGSVIDVAKAANVVYSLGGSAKDYLWPRNVEEKLRPLVAVPTTHGTGSEVTKYSVLVDRETGMKVAVSGSGLLPTLAVLDPLVLKHLPSDQSASTGLDALSHAIEAFFSSRATPFTDMFALEASRIAFRKLPCAVEGFLDCREWMLYASMLAGYAINYTGTNIGHGLGYPLTTRLNLPHGFANTVPLLGALEYYEKYAPERARLFAEHVGATGVGGLRGLFKELCREVGAPTSLSGLGVRREELDDYVREGLKYKRNLSNAPFEVTEEIVRDIYERVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX9</accession>
    <name>A1RYX9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1009"/>
    <dbReference type="EnsemblBacteria" id="ABL78409">
        <property type="protein sequence ID" value="ABL78409"/>
        <property type="gene ID" value="Tpen_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1009"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_3_2"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="139" mass="15513" checksum="E054A7ED78F1A10E" modified="2007-02-06" version="1">MEDCVFCRIVRGQLDAHFVYVGGRVVVFLDKYPVTRGHALVVPKDHYRDVFDAPGDVLSEMVFVAKVVALAQREALGARGVRLVMNSGREAGQEIFHAHMHVIPYGTERMDRRPLTRAEGEAVAEALRKALERLLGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ12</accession>
    <name>A1RZ12_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1,4-Dihydroxy-2-naphtoate prenyltransferase</fullName>
            <ecNumber evidence="9">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_1042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752707.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1042"/>
    <dbReference type="EnsemblBacteria" id="ABL78442">
        <property type="protein sequence ID" value="ABL78442"/>
        <property type="gene ID" value="Tpen_1042"/>
    </dbReference>
    <dbReference type="GeneID" id="4600947"/>
    <dbReference type="KEGG" id="tpe:Tpen_1042"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_2_2"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="OrthoDB" id="72417at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="303" mass="32478" checksum="33A2464FE860250C" modified="2007-02-06" version="1">MEVFCGVRLKELFIFTRPWSFVMTAISITGAAAYTYYLARSFDPLLYAATLLGVTLLHASANVLNDYYDTVRGVDVEGAPTTRYRPHPIIAGKMSAGQVRNFGLALMAGGLAFAFALALVRQVVVVLLALTGVVLLFTYSGPPGLKYRALGELGVFLSWGVFMWLGTFYVLTGELSLLPVLAGIPVGLLVAAVLTANNLRDIEFDSSRGAVTLAVVLGRSRGLAFYAFEVFSAYAATIALVLLGVLPLGSLLALLSLPQAFRLCKAFREKIPETADPLTAQLVQNFGLLYIAGILLSTLVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ39</accession>
    <name>A1RZ39_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752734.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1070"/>
    <dbReference type="EnsemblBacteria" id="ABL78469">
        <property type="protein sequence ID" value="ABL78469"/>
        <property type="gene ID" value="Tpen_1070"/>
    </dbReference>
    <dbReference type="GeneID" id="4601648"/>
    <dbReference type="KEGG" id="tpe:Tpen_1070"/>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="WVFHASG"/>
    <dbReference type="OrthoDB" id="100307at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="142" mass="15134" checksum="243E7AF13318BA2C" modified="2007-02-06" version="1">MRGDLGFRRKSLWVYHFNSGGCNGCDIEFVAALTPRFDLERLGVQLVPSPRHADVLVVTGPVTRASADALKTIYDQVPEPRIVVAFGTCACSGGVFSNCYNVLGGADKVLPVDVKIPGCPPKPESLLHALSRIVLGEANGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ40</accession>
    <name>A1RZ40_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase, chain 49kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752735.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1071"/>
    <dbReference type="EnsemblBacteria" id="ABL78470">
        <property type="protein sequence ID" value="ABL78470"/>
        <property type="gene ID" value="Tpen_1071"/>
    </dbReference>
    <dbReference type="GeneID" id="4601649"/>
    <dbReference type="KEGG" id="tpe:Tpen_1071"/>
    <dbReference type="eggNOG" id="arCOG01547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_2"/>
    <dbReference type="OMA" id="ISHPYAF"/>
    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="268"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="438"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="537" mass="60268" checksum="6938ED327DEAAB5C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ75</accession>
    <name>A1RZ75_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase class-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752770.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1106"/>
    <dbReference type="EnsemblBacteria" id="ABL78505">
        <property type="protein sequence ID" value="ABL78505"/>
        <property type="gene ID" value="Tpen_1106"/>
    </dbReference>
    <dbReference type="GeneID" id="4601100"/>
    <dbReference type="KEGG" id="tpe:Tpen_1106"/>
    <dbReference type="eggNOG" id="arCOG00086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431666_0_0_2"/>
    <dbReference type="OMA" id="SDRCVQA"/>
    <dbReference type="OrthoDB" id="82345at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="179" mass="20253" checksum="3F859D3F40B4B51E" modified="2007-02-06" version="1">MILIVSTCADRLSEYEFVKPLARILGRYDSYEVVSYREVGPGVVERYDKVVISGTALKDFDYLRYVDRFSWVKEFEGPVLGICAGLQLVSLVFRVGLRDKLVIGVREVEVVRENRLAKTGKLKAYFVTSKLPAPSSAVEVLGVSEGENVFFKVKDREVYALAFHPEVYNEEILASFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ78</accession>
    <name>A1RZ78_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752773.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1109"/>
    <dbReference type="EnsemblBacteria" id="ABL78508">
        <property type="protein sequence ID" value="ABL78508"/>
        <property type="gene ID" value="Tpen_1109"/>
    </dbReference>
    <dbReference type="GeneID" id="4601103"/>
    <dbReference type="KEGG" id="tpe:Tpen_1109"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_2"/>
    <dbReference type="OMA" id="WYVVVIC"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="426" mass="47155" checksum="FF65886E956B9DFA" modified="2007-02-06" version="1">MRSKYKWFVVLFFFTFLTIHQADRFIVSAVAPQVMDEFKVSYSQLGLVFSLTVLVAAFLYPVWGYLYDRYSRKLLAGLAALIWGFTTIFNALSRTFSEFFATRLATGIDDAAPPGIYSLVADYFDPYSRGKALGLLNATGPLGAIIGTILSLSIVAAGLSWRNAFFITGPIGVAIGALTFFLVKDVPRGVSEPELKDVLTEDIYRAKLSDLPKVLENKSLVLLYLQGFWGVFPWNAITFWFVTYMEKERGLSPDTVMVVMSLSLIAMVAGNIVAGIIGDWLFKKTKRGRAILGAVVVFFSAVLIYLAIRAESTEEFILFTVLTAFEIPMAAPNVVAAITDVTEPELRSSATGYLRFFENLGSATSPFLTGVLAESMGLGEAILLVSVYTWLLCFVFFAVLAAIIPRDIDRLRNLIRERAERLRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD5</accession>
    <name>A1RZD5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752830.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1167"/>
    <dbReference type="EnsemblBacteria" id="ABL78565">
        <property type="protein sequence ID" value="ABL78565"/>
        <property type="gene ID" value="Tpen_1167"/>
    </dbReference>
    <dbReference type="GeneID" id="4601181"/>
    <dbReference type="KEGG" id="tpe:Tpen_1167"/>
    <dbReference type="eggNOG" id="arCOG00701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_4_2"/>
    <dbReference type="OMA" id="YPEIKRT"/>
    <dbReference type="OrthoDB" id="51024at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="25778" checksum="6D9B0A44A0A1B3B7" modified="2007-02-06" version="1">MPGKNFSLTGHRGAAALEPENTLPSFLKAYECGATGIEFDVRLTRDGVVVAHDDELERVAGVKGRVSEKTYSELLGVRVGGRARIPTLREVLSLAKGRLSVDIELKVVGAEAEVVDSLRELRMVDDALVTSFVPEALRRVKELAPEVSVGVLLEEWDDEYLEIAEKLGAEALLPYYEALSRDLVERIKKRGFKVITWTVDDPEVAERLYRLGIDGVITDDPCLLARRLRFTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE5</accession>
    <name>A1RZE5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752840.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1177"/>
    <dbReference type="EnsemblBacteria" id="ABL78575">
        <property type="protein sequence ID" value="ABL78575"/>
        <property type="gene ID" value="Tpen_1177"/>
    </dbReference>
    <dbReference type="GeneID" id="4602043"/>
    <dbReference type="KEGG" id="tpe:Tpen_1177"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="CEYTGAV"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="356" mass="39484" checksum="B29A7398F8B874CE" modified="2007-02-06" version="1">MVRVVLENVSKTFKGGVNAVKNLNLTINDKEFMVLLGPSGCGKTTTLLMIAGVYKPTSGYIYFDDRIVNDLEPKDRNVGMVFQSYALYPHMTVYENIAFPLKLKKLPKGEIDRRVKEVASMLRIDNLLDRYPRQLSGGQQQRVALARAIAKQPDIFLMDEPLSNLDAKIRVEVRAELKRLQRELGITTIYVTHDQAEALSLADRIAVMNEGVLQQVGTPDDLYNRPANTFVAGFIGSPAANLVDADVVEAGGEYYLEMLGSRFKLPSDLAAIVKGESRVIFMVRPEDVKVVEGQGFLVYSVEWLGREALAHVRAPDGTLLRVLLPPESKLTIGAEVSVTFNYAKVHVYKPSGELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI9</accession>
    <name>A1RZI9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RanBP2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752884.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1221"/>
    <dbReference type="EnsemblBacteria" id="ABL78619">
        <property type="protein sequence ID" value="ABL78619"/>
        <property type="gene ID" value="Tpen_1221"/>
    </dbReference>
    <dbReference type="GeneID" id="4601718"/>
    <dbReference type="KEGG" id="tpe:Tpen_1221"/>
    <dbReference type="eggNOG" id="arCOG14518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697602_0_0_2"/>
    <dbReference type="OrthoDB" id="127293at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="3">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="395" mass="42745" checksum="94019685E8390486" modified="2007-02-06" version="1">MREVRLYLSRDKLSWLMYSSFFLSLLLVKPSRRPLLAVHYVHVDSPSLYGLYYRFLREEGLRDADEAVFRGVKALPCVVVDDQVVIEGRYVFARGALRLLKWYPFIDVLAFAASSALLVATVLGSTYAAVRLFPGAPGGLLAVLALLAASVAFAVAFYNVYVAALRGLVRVFLGALSVDPGRVGVPLDFEKPRGCGDVLAVEARALGLSANAFDAVDKARTSILLGRHDWLRCFLAAVDIALGRVKGPEELRRELEHSHELARSLKASLEKKVSSIGGWVCPSCGALNPPGNATCRACGSTRPIAGLEGLGPVHVDILRILYSMGGEATHGALLSRLGYEKPQVVDALRALFARKLISPALMQYEGRPVLGYRLTGEGAKVASVLAREASARRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ3</accession>
    <name>A1RZJ3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase M1, membrane alanine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Tpen_1225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752888.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1225"/>
    <dbReference type="EnsemblBacteria" id="ABL78623">
        <property type="protein sequence ID" value="ABL78623"/>
        <property type="gene ID" value="Tpen_1225"/>
    </dbReference>
    <dbReference type="GeneID" id="4601722"/>
    <dbReference type="KEGG" id="tpe:Tpen_1225"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_0_1_2"/>
    <dbReference type="OMA" id="CFDYPGQ"/>
    <dbReference type="OrthoDB" id="23096at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="11">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="10">
        <location>
            <begin position="232"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL78623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="823" mass="93191" checksum="6324D802263E5154" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK5</accession>
    <name>A1RZK5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/prolyl-tRNA synthetase associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1237"/>
    <dbReference type="EnsemblBacteria" id="ABL78635">
        <property type="protein sequence ID" value="ABL78635"/>
        <property type="gene ID" value="Tpen_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1237"/>
    <dbReference type="eggNOG" id="arCOG04332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_2_2"/>
    <dbReference type="OMA" id="VMLPATG"/>
    <dbReference type="OrthoDB" id="101418at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="160" mass="17401" checksum="329ABAB5C8F04470" modified="2007-02-06" version="1">MTAVLGAKDLESFLSSAGLRFEIVEVSRAATSLEASESLGVGLDRIAKTVVFKSDGGETVLVVVRADLKVDQSRLARLLGYRRLRLARREEVVEETGYEPGGVPPVGHRKRLKVYVDSRLLDAGEVYAGGGDERHLVRLDLRELVEKGFAAAVEVPVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL6</accession>
    <name>A1RZL6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752911.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1248"/>
    <dbReference type="EnsemblBacteria" id="ABL78646">
        <property type="protein sequence ID" value="ABL78646"/>
        <property type="gene ID" value="Tpen_1248"/>
    </dbReference>
    <dbReference type="GeneID" id="4600543"/>
    <dbReference type="KEGG" id="tpe:Tpen_1248"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="GSMPRID"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="332" mass="36534" checksum="0B6CB20822F1E479" modified="2007-02-06" version="1">MSALEDRQVLSARGVTVRFYTYAGVVHAVTDAYLDVYEGESVALVGETGSGKSVFTKALTGLIDPPGRIESGSVLFRRRDGRVVDLLKLSPEEVREIRGDEISYVFQDPSSALDPLYTAGDHIAETITEHRGVPKGDALREAVSLLRDVMIPNPEVRVKNYPHELSGGMRQRVVIATAIANKPRLLIADEPTTNLDVTVQAQILDLLKDLRSKYGMSLLLITHNLGVVAETADRVYVMYGGRIAETADVYTVFESPAHPYTQLLLRSVPNPLKKIERLESIPGTVPNLIDMKPGCPFAPRCPFAMEVCSREDPPRVDLGGGHVVHCWLHAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZM7</accession>
    <name>A1RZM7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752922.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1259"/>
    <dbReference type="EnsemblBacteria" id="ABL78657">
        <property type="protein sequence ID" value="ABL78657"/>
        <property type="gene ID" value="Tpen_1259"/>
    </dbReference>
    <dbReference type="GeneID" id="4600425"/>
    <dbReference type="KEGG" id="tpe:Tpen_1259"/>
    <dbReference type="eggNOG" id="arCOG07450">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825437_0_0_2"/>
    <dbReference type="OMA" id="CKASEYW"/>
    <dbReference type="OrthoDB" id="111896at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="336" mass="37494" checksum="B929A95864DC491E" modified="2007-02-06" version="1">MSSIRFGEVVSGRLSDHFYCWVRKPLDKGEVFAPDDPSKYWVYSLEEEEYTRFKNSFIKRPKGVLTLSLRSRKTFRYGFFQLAAALPSWGRGSPMLWFGFENEDLFGGGVAHFLFSEDELYAFAGAWGSSVLQLRLPVDVGELKRGSHVFTVRVYEGLAVWSVDSEVKGVAVLADTGQPVVAYEGAPYSAGVTGRSPPPSMGVLIDIDGGPGDEDWVWWNVNPWHLRVAEGGPRPFMALRLYEWGTGRQWEGFRASGRLVSQPVPTLGRSVTLTLAPANGMLRVEALTLSNRWVTVYERRVQGVARVYLDGGDLFSRFVYEPEGEQAISVAEVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ4</accession>
    <name>A1RZQ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752949.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1286"/>
    <dbReference type="EnsemblBacteria" id="ABL78684">
        <property type="protein sequence ID" value="ABL78684"/>
        <property type="gene ID" value="Tpen_1286"/>
    </dbReference>
    <dbReference type="GeneID" id="4600594"/>
    <dbReference type="KEGG" id="tpe:Tpen_1286"/>
    <dbReference type="eggNOG" id="arCOG07256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954776_0_0_2"/>
    <dbReference type="OMA" id="RERMPVK"/>
    <dbReference type="OrthoDB" id="123032at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="128" mass="13951" checksum="0D630CC39B8835ED" modified="2007-02-06" version="1">MSAPRLSEKEILDWGARIGVSARVENLKGSQIENLIASLDSFEGREALLVTAAFAQRQAQRLGTGRSTARLVTQALLDVYEKGGGKEEARKLLGFAKWVYEATAGSRPHVRPEQVTLESLLKAMVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV8</accession>
    <name>A1RZV8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1341"/>
    <dbReference type="EnsemblBacteria" id="ABL78738">
        <property type="protein sequence ID" value="ABL78738"/>
        <property type="gene ID" value="Tpen_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1341"/>
    <dbReference type="HOGENOM" id="CLU_1727326_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="16710" checksum="4636B72C1A76F7C2" modified="2007-02-06" version="1">MLPREVEERVREVCGELRRRGFDCDVSPEEFAAYMEADTYTGDRAGLWGVVGNRYLLIHELAEISALKRMGYRVDRGVLRRAYPDSYRAHLEAMDVELRVAAEEGDLGWVEARLRDLAGYLSDPLLPEGLAEEVGRLLRKYSGYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV9</accession>
    <name>A1RZV9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated protein, APE2256 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1342"/>
    <dbReference type="EnsemblBacteria" id="ABL78739">
        <property type="protein sequence ID" value="ABL78739"/>
        <property type="gene ID" value="Tpen_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1342"/>
    <dbReference type="eggNOG" id="arCOG01935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082641_1_0_2"/>
    <dbReference type="OMA" id="CAELNTV"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02619">
        <property type="entry name" value="TIGR02619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="70"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="31199" checksum="2F3D19A2953B85A5" modified="2007-02-06" version="1">MLVVSTVGTSILGNVETKWLDRVPEKYRGLVKGSSRLSVTDERQREFEARAHPGDELFDAVYRVLEASPREASAELNALLGFLERRKGSLAGADVELMFYSTDTGTGYFCARLVERYARERLRGALGGARVQVQEPVKLKKFGWGYEYFHEALLDMVDKAARLMANKKRSGYRVYVNATAGFKVEAAYLTLVSLLVGADSVFYVHEATRDVIELPVLPLGLKAKYADALRELREPTPRGALERRGVSVEELEEKGLVEVRDGLVVAREWVRKLLELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW8</accession>
    <name>A1RZW8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1351"/>
    <dbReference type="MEROPS" id="G05.004"/>
    <dbReference type="EnsemblBacteria" id="ABL78748">
        <property type="protein sequence ID" value="ABL78748"/>
        <property type="gene ID" value="Tpen_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1351"/>
    <dbReference type="eggNOG" id="arCOG02768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_0_1_2"/>
    <dbReference type="OMA" id="AMCVAFT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="311" mass="31997" checksum="31E5C43344280203" modified="2007-02-06" version="1">MGAWRRLAAFLAIAYALATAIDVAVYASGFRGALATVAWGAARMWSVALAVWLADRVNGTGWGVRGFLGSPSSALKLYLLSPLVAYAALGVYAVLATLLGLFDFDAYVELLAKALERSGAPSALAPALAVAGIASAYLAAVTVNAALALGEELGWRGYAYRLLGGEPGLKSTLVVGVAWALWHAPATILLGYNYPESRLLGLLPYSALLSAATYPLLLATTASGSVLPAASLHGAMNALWGLTVAASRLRGAEGELLLGMGVLGVAAWAIVAVALWAVAGRRRRAERLPEGAKPGEPGLAGGSVREDRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S013</accession>
    <name>A1S013_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753058.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1396"/>
    <dbReference type="EnsemblBacteria" id="ABL78793">
        <property type="protein sequence ID" value="ABL78793"/>
        <property type="gene ID" value="Tpen_1396"/>
    </dbReference>
    <dbReference type="GeneID" id="4600460"/>
    <dbReference type="KEGG" id="tpe:Tpen_1396"/>
    <dbReference type="eggNOG" id="arCOG01192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153285_0_0_2"/>
    <dbReference type="OMA" id="WHDVGPV"/>
    <dbReference type="OrthoDB" id="97046at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="150" mass="17087" checksum="661A2F0880E55DDD" modified="2007-02-06" version="1">MNNLELARSHINQALEIVRQATEALEGGNYPYVVRQCQETVELLLKAALRIVGIEPPKWHDVGPVLRRERARFPAWFQERVDELASISRSLRKEREAAMYGDEESGLPPEELYTRMDAEKALRDAKITLELVRQLYEEAARLSRGAGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1S074</accession>
    <name>A1S074_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_1457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753119.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1457"/>
    <dbReference type="EnsemblBacteria" id="ABL78854">
        <property type="protein sequence ID" value="ABL78854"/>
        <property type="gene ID" value="Tpen_1457"/>
    </dbReference>
    <dbReference type="GeneID" id="4600583"/>
    <dbReference type="KEGG" id="tpe:Tpen_1457"/>
    <dbReference type="eggNOG" id="arCOG04391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_2"/>
    <dbReference type="OMA" id="MSAYRCP"/>
    <dbReference type="OrthoDB" id="126197at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="58" mass="6599" checksum="98C63A426CE24983" modified="2007-02-06" version="1">MQEKKYKKYRCTVCGYVYSPELGDPDSNIPPGTPFEELPENWVCPVCGATKDLFEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A5</accession>
    <name>A1S0A5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--acetyl-CoA-carboxylase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1488"/>
    <dbReference type="EnsemblBacteria" id="ABL78885">
        <property type="protein sequence ID" value="ABL78885"/>
        <property type="gene ID" value="Tpen_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1488"/>
    <dbReference type="eggNOG" id="arCOG01940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_2"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="74"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="34408" checksum="789D74D59C9B6317" modified="2007-02-06" version="1">MDGKELRRRVLEVLARRGGYVRGGELAEKLGVSKVAIHRAIVGLRKMGYVVESHPRRGYRLVSSDNLADANAVVAGAGRTLRYTAYYVKTCGSTQDVADALASQGAEEGTVVVAESMTSGRGRLGRRWFAGPGGLWFTVILRPQQMKHLQLLSLAAGLSVAKSVRGLYGIDARLKWPNDVVVGERKLCGILVEGKAEADALKYLLLGVGVNVNNEVPEGLEGVATSIKEILGHPVPRLPLLKAILAGLDGYYAALKRGEPGRVVEEWKTLSSTLGRRVRVSIVGGGVVEGVAVDVTSRGELVVQKDTGGRVTVDAGDVEHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F0</accession>
    <name>A1S0F0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1534"/>
    <dbReference type="EnsemblBacteria" id="ABL78930">
        <property type="protein sequence ID" value="ABL78930"/>
        <property type="gene ID" value="Tpen_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1534"/>
    <dbReference type="eggNOG" id="arCOG09422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1446925_0_0_2"/>
    <dbReference type="OMA" id="WWSWVIA"/>
    <dbReference type="OrthoDB" id="99624at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="191" mass="20351" checksum="3FE19758CF44576E" modified="2007-02-06" version="1">MATELKRSRKVLSTTDIVAMGIGTALYAAFNVFFNILQIPGSQLVSVRPSVSIPMFFGHVFGPVVGFVVGFLGNTISDAVSWGGFWWNWDVGNGLLGLISGLASYIIKREELLEKKGLMVASVLAVVGSIVGMGFASFTDYIFGYGISTIEEAIYALFLPAAVTDAVNGAILTPVLIKAYSAAVKGRSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F9</accession>
    <name>A1S0F9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753204.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1543"/>
    <dbReference type="EnsemblBacteria" id="ABL78939">
        <property type="protein sequence ID" value="ABL78939"/>
        <property type="gene ID" value="Tpen_1543"/>
    </dbReference>
    <dbReference type="GeneID" id="4600836"/>
    <dbReference type="KEGG" id="tpe:Tpen_1543"/>
    <dbReference type="HOGENOM" id="CLU_1109549_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="250" mass="27038" checksum="61EE84DB106AE718" modified="2007-02-06" version="1">MGTTLKESSGVKRRISTQDVALVAVMAALANVLGFFAIPGPWNIQFSMTGIPILLVAFTRGPLLGALTGLLGGYVQAVKYGWEGYVVYTAIQGGVAGFFAKKVRLLRVLAPPFFFFGGFFLTWWVDQMRYGKVTFEDLVSMTQRAVAAGPETGLAVPYVSIVSGVVAAAVAALLVLRFPENRRLLLTLAGCMGAIAYVPYDAFALYVVQQYPWIPTWFVLAKDLVQDFVAAGITASILENKRVRRLLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H0</accession>
    <name>A1S0H0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753215.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1554"/>
    <dbReference type="EnsemblBacteria" id="ABL78950">
        <property type="protein sequence ID" value="ABL78950"/>
        <property type="gene ID" value="Tpen_1554"/>
    </dbReference>
    <dbReference type="GeneID" id="4600903"/>
    <dbReference type="KEGG" id="tpe:Tpen_1554"/>
    <dbReference type="eggNOG" id="arCOG00227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_0_0_2"/>
    <dbReference type="OMA" id="GQELAWK"/>
    <dbReference type="OrthoDB" id="112836at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="354" mass="38857" checksum="045595AAC9767CF1" modified="2007-02-06" version="1">MPKLKVLGILLVIVLAVAIGALVYFGSKPSQPATPAKAVVELPTGERIEVPENVAGKVVFYTSIPDVIVNSWKGNWSKYFGSTISLEVWRSGTGKVVAKLLAEKKAGSVEADVVYIASPFEFETLINESIIEKFPDIPELKYIPQEYRDPRGYYVWGRVLVMVIVYNPNIVTDPPKSWQDLVKPEWKGKVVIANPLYSGSTQVAVAALASKFGWSYFEKLKENDVLVVQDVPDVARVVATGERPVGVTLTMYLGAYPTLKFVAPEEGAIAIPSPVGLVKNAKHPEDAKVFLRFLLSKLGAQALTDAYTYSTRIDAPAPKGLPPLSQLKILKVSMDELRPIVSQIRDKWTQIFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H8</accession>
    <name>A1S0H8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative circadian clock protein, KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1563"/>
    <dbReference type="EnsemblBacteria" id="ABL78958">
        <property type="protein sequence ID" value="ABL78958"/>
        <property type="gene ID" value="Tpen_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1563"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168626_0_0_2"/>
    <dbReference type="OMA" id="GMSARRF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="26881" checksum="CA7F28642DB45A2C" modified="2007-02-06" version="1">MERARTGIKGLDEALEGGLPRPSSVLVAGSIGSKKNTFAQRILYEGLLEGEKGIYVTVDLFPEDIVENMEKYGMSARRFIEEGRLVFIDCFSPRVGVESSARYLVENPFDLDEVLREIVVAKREFLEPGDRYRLVISHLSTLFFSASKELIPGFIGRLHAEARRSRGIHVMVYSEGVLNKHYECFLKSLPDVVFELSRRGSSRYLRILRCIKTSYPLTPFRLSHDMSAATPVEGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I8</accession>
    <name>A1S0I8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753233.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1573"/>
    <dbReference type="EnsemblBacteria" id="ABL78968">
        <property type="protein sequence ID" value="ABL78968"/>
        <property type="gene ID" value="Tpen_1573"/>
    </dbReference>
    <dbReference type="GeneID" id="4600559"/>
    <dbReference type="KEGG" id="tpe:Tpen_1573"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_2"/>
    <dbReference type="OMA" id="LHFGDTH"/>
    <dbReference type="OrthoDB" id="25870at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="391" mass="44017" checksum="E957612B250313C9" modified="2007-02-06" version="1">MEVLRIVHTADNHLDPKFTFLGPKVRDRREDFLNAFRRVVDFAVEAKPHLFLVSGDLFDSVNPRNPVRVQVIRAFRRLYSEGVRVYVIAGNHDMPRSLEEGLSPLKEVEASGYARFFEKTSEFEVDHFEVNGFDVAVAGISYNPEVGLDEHPLRKYNARVPREGDIEVVLMHYNFAGVEVPGAWRAPRITREDIPDNCVYAALGHVHSRVTIPLGNGGVAAYPGSTERRSFIEEGDGAKGFLYVKVHGDGRVETEFKEVPTRPIKTVRVQVPPSAEDPVGYVLSSLPPPDPRLLLRVLVEGSIPLARLTRYSRAELLKNAEKRFFHVVVEDSELRCAYAEKPSVAVESKSPIEAFREEVEGRLREAPEEDRIILLKALERGVKALEESGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L0</accession>
    <name>A1S0L0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753255.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1595"/>
    <dbReference type="EnsemblBacteria" id="ABL78990">
        <property type="protein sequence ID" value="ABL78990"/>
        <property type="gene ID" value="Tpen_1595"/>
    </dbReference>
    <dbReference type="GeneID" id="4601464"/>
    <dbReference type="KEGG" id="tpe:Tpen_1595"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_1_3_2"/>
    <dbReference type="OMA" id="CAKDIRY"/>
    <dbReference type="OrthoDB" id="121662at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="157" mass="18003" checksum="4AE68DB26757527C" modified="2007-02-06" version="1">MLHKKLKLKGYLKLLVLAALEKGPLHAYGLMKELEKSLGFRPSPGALYPILRKLIREDLVVAELRGSGDVKTRVYNITEKGRSFLEHHRGELEEALSLARAWKRFEEVKGYRLFHAIDEILDSINSLDDQRLAELRRLIAEFELNVIRVLEGVKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R0</accession>
    <name>A1S0R0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">Tpen_1645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1645"/>
    <dbReference type="EnsemblBacteria" id="ABL79040">
        <property type="protein sequence ID" value="ABL79040"/>
        <property type="gene ID" value="Tpen_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1645"/>
    <dbReference type="eggNOG" id="arCOG01919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_2_2"/>
    <dbReference type="OMA" id="HFWKSIF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="289" mass="32861" checksum="71283AE517E97A1E" modified="2007-02-06" version="1">MFNSAPRASHEVLAVSEELPEKPLLDHVYDFLETLRRILIEFIAFLILLIFLPAPWMLPRSYYPLVFALMNATNHYMLDFNDNPFSGPFARLFGVNGSRVVLISHGWFDSLTAALLLSVVIAAGVLSPLIAYEVYRFVEPGLYSHEKRVVKRYTVFALSLFVAGLLYGYFVVMPIVFSVAVWLATLGGASLFFSIQEFYQNIMLGTLATGVFFMFPLVVLALHKIGVVTYETLRGNWRYVVFAVFAFLVMVTPDPTFFSDLVLGAPFVALYFLSMWLVKREERKEKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S3</accession>
    <name>A1S0S3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753318.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1658"/>
    <dbReference type="MEROPS" id="S54.027"/>
    <dbReference type="EnsemblBacteria" id="ABL79053">
        <property type="protein sequence ID" value="ABL79053"/>
        <property type="gene ID" value="Tpen_1658"/>
    </dbReference>
    <dbReference type="GeneID" id="4601735"/>
    <dbReference type="KEGG" id="tpe:Tpen_1658"/>
    <dbReference type="eggNOG" id="arCOG01768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611948_0_0_2"/>
    <dbReference type="OMA" id="IWFAEQV"/>
    <dbReference type="OrthoDB" id="65819at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rhomboid" evidence="5">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="444" mass="47602" checksum="F4330BB35A2D1E09" modified="2007-02-06" version="1">MGLPFQRDYEDIERRGAPVTLGIILVNVAVYLVSSYENGFLAVSDAWVNAFAFVPAYFARPEHLYRLFTSMFLHANLAHIFFNMLYLYTFGKSVEAVLGSERYFLLYFASGILASVFHTAFLPIEGASSAFVPALGASGAISGVLGAYLLLFPGTRLTMCFFYVFIPLCFTMKAAAYLVFWFALQILQGFLGASLGVAVFAHAGGFIGGLALLPVLVSEERIGLLRLYSSMHYFFRNIFFTERGFTRLSKAVVAVLIGLVAAAAVYSAVEAETTGGVNKVLTVSVTGRGVNDSESVIIQLQPGGVLDVTPISSSGVRVVVNRLRAANLLYNSQAAGKSISVDKSLRGVVNGLPVEITIKANLSFDSYGLLDRGQGHVTTDVLACDAYGRCTVSGKGSYDFSVSSEATMAGFKGIPIAELALLSLASSLAAVVNVLRAERYAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S6</accession>
    <name>A1S0S6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753321.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1661"/>
    <dbReference type="EnsemblBacteria" id="ABL79056">
        <property type="protein sequence ID" value="ABL79056"/>
        <property type="gene ID" value="Tpen_1661"/>
    </dbReference>
    <dbReference type="GeneID" id="4601243"/>
    <dbReference type="KEGG" id="tpe:Tpen_1661"/>
    <dbReference type="eggNOG" id="arCOG04166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508673_0_0_2"/>
    <dbReference type="OrthoDB" id="57080at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018693">
        <property type="entry name" value="DUF2192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09958">
        <property type="entry name" value="DUF2192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="535" mass="59374" checksum="767641503A334C7F" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W2</accession>
    <name>A1S0W2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1697"/>
    <dbReference type="EnsemblBacteria" id="ABL79092">
        <property type="protein sequence ID" value="ABL79092"/>
        <property type="gene ID" value="Tpen_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1697"/>
    <dbReference type="eggNOG" id="arCOG01195">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_4_2"/>
    <dbReference type="OMA" id="YARGDWL"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="10615" checksum="1650BDDCD63B857D" modified="2007-02-06" version="1">MESIRRVCGDARVYLFGSYARGTWVEDSDVDLVVVSRCFEGMEPGERYRFVRGLASRELAFEFLVYTPEEFEEALKRSVVVQDAMEYAVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X4</accession>
    <name>A1S0X4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1709"/>
    <dbReference type="EnsemblBacteria" id="ABL79104">
        <property type="protein sequence ID" value="ABL79104"/>
        <property type="gene ID" value="Tpen_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1709"/>
    <dbReference type="eggNOG" id="arCOG06028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143936_0_0_2"/>
    <dbReference type="OMA" id="AFEIHEM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="149" mass="16643" checksum="0CC12128AB970A6D" modified="2007-02-06" version="1">MDSTYLLPIVGVNVEGVEGTLALLKKLRDSGVAEYYYTQFNILEIVGKLSRVGYNSSRALAGLASIFEEFIEESPTVEGVMKALELRRKGHRDLIDLLLYTTSLTRGLLFLTRDVHLVGFLKKQGEPTHNVILEEELAEKYGQSPAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y0</accession>
    <name>A1S0Y0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.14" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753375.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1715"/>
    <dbReference type="EnsemblBacteria" id="ABL79110">
        <property type="protein sequence ID" value="ABL79110"/>
        <property type="gene ID" value="Tpen_1715"/>
    </dbReference>
    <dbReference type="GeneID" id="4601740"/>
    <dbReference type="KEGG" id="tpe:Tpen_1715"/>
    <dbReference type="eggNOG" id="arCOG01392">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_2"/>
    <dbReference type="OMA" id="WFPYPEE"/>
    <dbReference type="OrthoDB" id="18594at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="362" mass="40116" checksum="3282EB74D2E167F7" modified="2007-02-06" version="1">MTKVVSIVGARPNFVKLAAVAETFDREFEHTVIHTGQHYDYEMSKVFFEQLRLRDPDIHLGVGSGSQGYQVGEIVKKAEEHLKSINPDVVVVYGDTNSTLAGALAAAKAGYPVAHVEAGLRSHDMKMQEEINRRVVDHVSALLFAPTPSARDNLLKENVPGKVFLTGDVHVDVLQKWIESIQRSNILGRLGLLEGEYVMATIHRAENVDDPAKLAEVIKCLKELAALTKVVFPIHPRTRSRAEEAGLEKELYSNPNLVATKPLGYVDFLRLVTGSKLVVTDSGGVQREAYLLGKPAIVLRDRTEWIELVQAEWVRLADANPARLVQEYKKLLEKPPAPQPGLLGDGKAAERITKTISELMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y3</accession>
    <name>A1S0Y3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1718"/>
    <dbReference type="EnsemblBacteria" id="ABL79113">
        <property type="protein sequence ID" value="ABL79113"/>
        <property type="gene ID" value="Tpen_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1718"/>
    <dbReference type="eggNOG" id="arCOG00566">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395690_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="696" mass="78863" checksum="49B4203B31B8E4F6" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z6</accession>
    <name>A1S0Z6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753391.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1731"/>
    <dbReference type="EnsemblBacteria" id="ABL79126">
        <property type="protein sequence ID" value="ABL79126"/>
        <property type="gene ID" value="Tpen_1731"/>
    </dbReference>
    <dbReference type="GeneID" id="4601756"/>
    <dbReference type="KEGG" id="tpe:Tpen_1731"/>
    <dbReference type="HOGENOM" id="CLU_644996_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="403" mass="41905" checksum="D9C4595269F90BE9" modified="2007-02-06" version="1">MSKRYLVAALAALLLASPVLAISTRRPETPLLLNLTVYPPGLALKELSTTRSGLAAVFVNTADKEVAVDKLYLAVEPPESFQCAISVPPLLETPPGPCSYNSSKDPLFKAPRVEPGGRVAVLVALSGTLRLTALNQSEEAVLKLGVGNATLVKKLRLYGWVDGEAKTLGRPGELEVRLVFGGNSTARLAVSGARVEVAGATLKNLRVVEAANFSGSVKAENGSIVVDGYASPPASIRVVAEAYSTVGVGGASPRVVLRLGDSEKAIGRAEVPAAKLVDLKPLLGFLPYAYEVSVEGGGNGYAAVRVGPHTYNVTLTGGRGSLTLGEAFWPLLSSYPVEPVSVALIEGNATREYPAVPPGEAPRVTTGLALLAIILASAAAVALLVRRAAKLEKQCGPVIEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z7</accession>
    <name>A1S0Z7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH DNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753392.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1732"/>
    <dbReference type="EnsemblBacteria" id="ABL79127">
        <property type="protein sequence ID" value="ABL79127"/>
        <property type="gene ID" value="Tpen_1732"/>
    </dbReference>
    <dbReference type="GeneID" id="4601757"/>
    <dbReference type="KEGG" id="tpe:Tpen_1732"/>
    <dbReference type="eggNOG" id="arCOG04189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182708_0_0_2"/>
    <dbReference type="OMA" id="AYIMFAT"/>
    <dbReference type="OrthoDB" id="124010at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="91" mass="10143" checksum="78E454500CE5559F" modified="2007-02-06" version="1">MNKDQLVGTAIMLASIAGILVYGWILFFTQWSLLLLQLTGFVAVAGVLGILAWIGFTLATTPPPKPIEEIEKEIEEELKKLEAEEKKEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S103</accession>
    <name>A1S103_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753398.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1738"/>
    <dbReference type="EnsemblBacteria" id="ABL79133">
        <property type="protein sequence ID" value="ABL79133"/>
        <property type="gene ID" value="Tpen_1738"/>
    </dbReference>
    <dbReference type="GeneID" id="4601763"/>
    <dbReference type="KEGG" id="tpe:Tpen_1738"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526426_0_0_2"/>
    <dbReference type="OMA" id="WHQYAVA"/>
    <dbReference type="OrthoDB" id="5654at2266"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="335"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="514" mass="52471" checksum="7B62369A98736F94" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S104</accession>
    <name>A1S104_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin (Vitamin B12) biosynthesis CbiM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753399.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1739"/>
    <dbReference type="EnsemblBacteria" id="ABL79134">
        <property type="protein sequence ID" value="ABL79134"/>
        <property type="gene ID" value="Tpen_1739"/>
    </dbReference>
    <dbReference type="GeneID" id="4601764"/>
    <dbReference type="KEGG" id="tpe:Tpen_1739"/>
    <dbReference type="eggNOG" id="arCOG02248">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_2_1_2"/>
    <dbReference type="OMA" id="PWGTSGH"/>
    <dbReference type="OrthoDB" id="92958at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL79134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="204" mass="21142" checksum="DA0E623B083AD0C1" modified="2007-02-06" version="1">MHIPDGYLDPAMCAVTYALSLAVLAFSALKARSAGSEQKTLVPVLAAAIFAAQMLNWPIPGGTSLHLVGGALASILVGPWLASLTMFLVLLTQALVFHDGGITTLGANVLNMGIVAVFAGYLAYRAFPERLRVVGAFLAGWLSITLAGVVCGVELGLSKQFLYGLSVTVPVMGGWHALLGVVEGLITASVYAYLKSKAPQLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S112</accession>
    <name>A1S112_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753407.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1747"/>
    <dbReference type="EnsemblBacteria" id="ABL79142">
        <property type="protein sequence ID" value="ABL79142"/>
        <property type="gene ID" value="Tpen_1747"/>
    </dbReference>
    <dbReference type="GeneID" id="4601772"/>
    <dbReference type="KEGG" id="tpe:Tpen_1747"/>
    <dbReference type="eggNOG" id="arCOG06071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160446_0_0_2"/>
    <dbReference type="OMA" id="GYAKTQL"/>
    <dbReference type="OrthoDB" id="128679at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12538" checksum="214D6A3894D8E2FF" modified="2007-02-06" version="1">MKRVRCYPNEKVEGVTVFVPRGHSHVRVILELEDQVVVLHEATVAAIARAYMDVVAHPLRRAVQLRRAALAERKRGYAEHQLLEVDRGEDEIVEEAEKVLEACAERVSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S122</accession>
    <name>A1S122_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1757"/>
    <dbReference type="EnsemblBacteria" id="ABL79152">
        <property type="protein sequence ID" value="ABL79152"/>
        <property type="gene ID" value="Tpen_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1757"/>
    <dbReference type="eggNOG" id="arCOG01426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_0_0_2"/>
    <dbReference type="OMA" id="NRNTEAI"/>
    <dbReference type="OrthoDB" id="127239at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="305" mass="36384" checksum="809B528FFB16386B" modified="2007-02-06" version="1">MELLSKEEKLRILRTLEEDAEFRHAVAGLIGMREILEKLDRLWEEVRDLREEQARTWKEIEKVWGEIEKLREEQAKTWKEIERLREEQAKTWKEIEKLREEQARTWKEIKKVWEEIEKLREEQTKIWEEIEELRKEQTKMWEEIKGLREGQTKIWQEIAELKEGQGKIWVTLNRLSKTVERLTLTVEEEAGEVISYRMREEMGVRIALSSIVVDDKEINVYGVSDDLCVVGEATVRLGDELVKELERKVEYIAKARPDLLRSRMIKVIYADYATPSALRLAEEMGIWVLKWSGDLTPRVVHSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S153</accession>
    <name>A1S153_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1788"/>
    <dbReference type="EnsemblBacteria" id="ABL79183">
        <property type="protein sequence ID" value="ABL79183"/>
        <property type="gene ID" value="Tpen_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1788"/>
    <dbReference type="eggNOG" id="arCOG05807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764239_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="362" mass="40213" checksum="956C1AAFF5B94316" modified="2007-02-06" version="1">MHRKTLGLVLLLLLVASLAGVAPVVSAQQASTEQERLQRHISFLLNQTARLENFVNSRVSNATLKELLLQQISTARSTLQQALQTLQSGDVNGTKELVREASAELRSVALQLYKEIREREKLRAAHLLEVEIRVLQNQLRALRNVASRLGSLGADTSNVTRLIDEASSLLDQALNSLKQNNMAQASQLVEQARLKVKEAERSIWSLAVQLRSKRAEKDLELFANASRKVYERLLKVSPGLAAQFKNWSDARISEIKKLISEGKHVAALEEIRKSFHRMGWVVAGLAELGRVEALAREGERVASVIKVCNATLAGEISKVAAQLRDAASKRDLQKVRELSAQLRDLLVEARFACRPGHRKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1S164</accession>
    <name>A1S164_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753459.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1799"/>
    <dbReference type="EnsemblBacteria" id="ABL79194">
        <property type="protein sequence ID" value="ABL79194"/>
        <property type="gene ID" value="Tpen_1799"/>
    </dbReference>
    <dbReference type="GeneID" id="4601922"/>
    <dbReference type="KEGG" id="tpe:Tpen_1799"/>
    <dbReference type="HOGENOM" id="CLU_1154399_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="248" mass="27388" checksum="400A58663FBF84CC" modified="2007-02-06" version="1">MRGERVLVKPLEAGWVPAYLRGVAVVLVGLLSALKYEFWVAPLAYLGAEALAVGGVSRFERVAVGVFYALLSALWLAGVQAAPALSGIVLAFAGLLYLALLEAEVKSAVYVLTRDELVLPFSDVENLVFKERRVRVGSRKVILRVRRPFWSRLLGKRFEEVEVAAEEGVVRLRGIPDGNRVAQLIEERAGRRRTLRSTATRAKPREQRGSLQGYLGVTDGSPGRPEEPPRKGNSEILHRKNLIDDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S173</accession>
    <name>A1S173_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753468.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1808"/>
    <dbReference type="EnsemblBacteria" id="ABL79203">
        <property type="protein sequence ID" value="ABL79203"/>
        <property type="gene ID" value="Tpen_1808"/>
    </dbReference>
    <dbReference type="GeneID" id="4601801"/>
    <dbReference type="KEGG" id="tpe:Tpen_1808"/>
    <dbReference type="eggNOG" id="arCOG00221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032622_0_0_2"/>
    <dbReference type="OMA" id="FYGYTAM"/>
    <dbReference type="OrthoDB" id="26557at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="514" mass="56249" checksum="302316E691E245AE" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S199</accession>
    <name>A1S199_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753494.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1834"/>
    <dbReference type="EnsemblBacteria" id="ABL79229">
        <property type="protein sequence ID" value="ABL79229"/>
        <property type="gene ID" value="Tpen_1834"/>
    </dbReference>
    <dbReference type="GeneID" id="4602071"/>
    <dbReference type="KEGG" id="tpe:Tpen_1834"/>
    <dbReference type="eggNOG" id="arCOG14929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801798_0_0_2"/>
    <dbReference type="OrthoDB" id="127686at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="139" mass="15717" checksum="E162F27F6F6007D8" modified="2007-02-06" version="1">MKKVLWALDIPAFREAVRLLEESLKDQVQVVGVGPLYSADEVLKLIRELEADEVVTAIEDPCEMNKLLSSGVQPLVMITEDVAECGSREECLEYESKGYLLLEKEDGVKVVALKEFLRVVDIMFQLVEPSEVHVHDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A2</accession>
    <name>A1S1A2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753497.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1837"/>
    <dbReference type="EnsemblBacteria" id="ABL79232">
        <property type="protein sequence ID" value="ABL79232"/>
        <property type="gene ID" value="Tpen_1837"/>
    </dbReference>
    <dbReference type="GeneID" id="4602074"/>
    <dbReference type="KEGG" id="tpe:Tpen_1837"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_2"/>
    <dbReference type="OMA" id="MFGCYSD"/>
    <dbReference type="OrthoDB" id="62994at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="135"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="356" mass="39679" checksum="D1FCDFF590C1E434" modified="2007-02-06" version="1">MDIEAWVCEVPLREPLRISAATYHTQRSIVLRLRDGDLEGWGEACQSRRVLGESFEDALESLRASVDAIKRAEYDSLEKIHRFTEELNATPSIKAAVNMALLDLYAKSEGRPLWRLLGGFREEVRTDITIGIMRPEEMAERALRYAEKGFRIFKLKLGENPEEDVLRVKAVRDVVGDATIRVDANEGWTREDAVRVIERIADYGVELVEQPLRHDDIEGLRALRRESPIPIAVDESVKTARDALLVAKKEAADIINIKLMKSRGITGAIRIIMVSEAAGLKNMVGCFSESRLGITATAYLAQAFSNVLFYDLDCDILSADPVFTGGSEPIGDRRRASPKPGLGISPSNFNVLKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D3</accession>
    <name>A1S1D3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="7">pTPEN01</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1868"/>
    <dbReference type="EnsemblBacteria" id="ABL79263">
        <property type="protein sequence ID" value="ABL79263"/>
        <property type="gene ID" value="Tpen_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1868"/>
    <dbReference type="eggNOG" id="arCOG04811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2353362_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="96" mass="9990" checksum="0D3EC228DF0A77BF" modified="2007-02-06" version="1">MELAGVGAVSVVLGYAVRKGVNFILGLLGVFVAFLLVLQALGYAVVDWAKLVNDAYGLLESLLSQQDLASKLEQVLPGGLVGIAGFMVGWKLGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1F6</accession>
    <name>A1S1F6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6 7">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="7">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751411.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1891"/>
    <dbReference type="EnsemblBacteria" id="ABL79286">
        <property type="protein sequence ID" value="ABL79286"/>
        <property type="gene ID" value="Tpen_1891"/>
    </dbReference>
    <dbReference type="GeneID" id="4600305"/>
    <dbReference type="KEGG" id="tpe:Tpen_1891"/>
    <dbReference type="eggNOG" id="arCOG01241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_2"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0614">Plasmid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="99"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="31009" checksum="DE77990A7A57248D" modified="2007-02-06" version="1">MQEAVAKPEDIRALVENYLGVVKALRSHNTYKTYASVLFAYAKFVEDTGKPDPAAFISWLEKNGWEKRTSIRTAYVVLRGFHKFAGLPWTLPPVKKPESVPKALGTEDVRKLLSVASPAEREVIVFLLKTGLRVSEFVHSRCEDVLVVGDGRYMLRVRGKGDKVRLVPLTKDVVEIIKARCTGRAGYIFPSPLDPDKPVSARSIQHLVSRVARRAGLQRVTPHTLRHTYATLLLNNGVDIRTIQTLLGHAQLTTTQVYTKVDVARMVDAIDSALTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW53</accession>
    <name>A1RW53_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4430 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0023"/>
    <dbReference type="EnsemblBacteria" id="ABL77433">
        <property type="protein sequence ID" value="ABL77433"/>
        <property type="gene ID" value="Tpen_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0023"/>
    <dbReference type="eggNOG" id="arCOG09431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691628_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027954">
        <property type="entry name" value="DUF4430"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14478">
        <property type="entry name" value="DUF4430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4430" evidence="2">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="165" mass="18157" checksum="D2B376FFEC49CAF0" modified="2007-02-06" version="1">MDKNPICVSGEKSPGRKIAGLLVLALLAWAIIASGFAAYLYLENERLSASLRSYASRTVLVNIGIDYGNGTIVWFNSTPLPSGSSALTALVAVAKVEYKTSQMGAYVTSVNGVSEKFLSKNEGYSWLWYRYDPGKSQLVMGQVAADKYILANGDVIVWRYEHWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW59</accession>
    <name>A1RW59_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0029"/>
    <dbReference type="EnsemblBacteria" id="ABL77439">
        <property type="protein sequence ID" value="ABL77439"/>
        <property type="gene ID" value="Tpen_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0029"/>
    <dbReference type="eggNOG" id="arCOG15045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519943_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="98" mass="11333" checksum="F20D5FDE95A78983" modified="2007-02-06" version="1">MWVNNIFAFRGELYVAGKKRFIARVDEEGNVKLPLAVLKDMGVTLPAYVSITREGSALLLRFRTKRSPLRLGRQIRTEEMEKLIKEALDELVIARWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW90</accession>
    <name>A1RW90_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0060"/>
    <dbReference type="EnsemblBacteria" id="ABL77470">
        <property type="protein sequence ID" value="ABL77470"/>
        <property type="gene ID" value="Tpen_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0060"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_1_2"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="239" mass="25659" checksum="BDCF418CFC3DA71F" modified="2007-02-06" version="1">MAKPLHILAKPEDIAPRVIASGDPARVKQLSSYLDNPRLVNENRGFLVYTGTYKGVPVTVATHMIGAPSAAIVFEELIMLGAKLIVRFGTCGGFLPEMRVGDFVIATGASYSGGGTMNTYSPGECMAAVPDYDVLSALVESASRHGLKYFLGPVVSSDNFYSGIEYLNRWINRGMIAVDMEAATLFVVGRLRRVKTGASFVVSDVIGEAYKKMATAEELREAVDKASRAVLDAVISVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB7</accession>
    <name>A1RWB7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751762.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0087"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77497">
        <property type="protein sequence ID" value="ABL77497"/>
        <property type="gene ID" value="Tpen_0087"/>
    </dbReference>
    <dbReference type="GeneID" id="4601398"/>
    <dbReference type="KEGG" id="tpe:Tpen_0087"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779883_0_0_2"/>
    <dbReference type="OrthoDB" id="90709at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="374" mass="42464" checksum="91E51C4E2BE37D90" modified="2007-02-06" version="1">MSSSERARVSVIVTVYRHARRLRSLLEALCNQETSFPVEVIVVADEPDEEVLGILREKACVKSLVSENRRGKVRALNEAISLSQGDVLIFLDNDVTVQDRKFVEKIYKWLQDFDVAEIKKIARVDTFIGKLVYYDYMSFGVASYIFEKRVKRCAGLNGAAMAFTRKALKELGGYRNVVLEDMDIGFRSFFHGFRYKYIWDTEVVVDPPSSLREWLNQRLRWSVGAWTWIDDYVFHFSKIASIDYALESFAALFAMFPGGIVYASILLAEGLPLLKLGLLAGSTVGGLFAPLVPVLAIYETVSMFLPPLPLSLVAIAVAYSALVVPIAYRIGYKVKPQHFATYILFYSTLWFTVMLAGFIRVFVFRKRDVTGWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE4</accession>
    <name>A1RWE4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751789.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0114"/>
    <dbReference type="EnsemblBacteria" id="ABL77524">
        <property type="protein sequence ID" value="ABL77524"/>
        <property type="gene ID" value="Tpen_0114"/>
    </dbReference>
    <dbReference type="GeneID" id="4600646"/>
    <dbReference type="KEGG" id="tpe:Tpen_0114"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_0_2"/>
    <dbReference type="OMA" id="HAIAYMT"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="138"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="399" mass="43542" checksum="A90F9BEBDAF6C7EF" modified="2007-02-06" version="1">MGLIEGRYEAVVIGLGPAGAAALKRLQELGIKAVGIERKKAPEEPAVCGEFLPEPSAIEFISRFPSVRKAYEYIGLARRTNAIRRIILSFAGGKTYNLEIPGFTVSRKEMVSKLIEGSDYVTGSDVVGIRRVGDAYLVKTRRGKEFSASYVIAADGFPSATRRLLGLPAGLQPEDYAVGVNLKMETPSMPRDTIFMYASSFTQGGYAWIIPVGDGLSNVGIGLRFNYVKKGANPLKALTSFVELERRGFLDSSRQLEEPRSRMIPVSGFYSEPSTGKVLFAGDSLGAVNPINGGGIFTAMALGILAAESVWLGNPGIYDERSWREIGQVLSIGRAYRVLVDFLYEHFDHVAVLTALFPRFLLEKILKGEKTPIKGILEIGIGRKTSYRPPRGQASRKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF4</accession>
    <name>A1RWF4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751799.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0124"/>
    <dbReference type="EnsemblBacteria" id="ABL77534">
        <property type="protein sequence ID" value="ABL77534"/>
        <property type="gene ID" value="Tpen_0124"/>
    </dbReference>
    <dbReference type="GeneID" id="4602186"/>
    <dbReference type="KEGG" id="tpe:Tpen_0124"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_3_0_2"/>
    <dbReference type="OMA" id="VAYTHLH"/>
    <dbReference type="OrthoDB" id="90041at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NikR_C" evidence="1">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="130" mass="14936" checksum="5A7FFFB074262BFC" modified="2007-02-06" version="1">MRDKRRVGVSLDGDVFEELERVAKAFNTDRSHIVNMAAREYLLEKFHYAKPHSCEGVMIISYDPARGQEVAEAIEESKSLVVSRSHFHTGDGCCLEILYLKGDSEEIWLLEKRVSHLCDVCRFVPSHRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF7</accession>
    <name>A1RWF7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751802.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0127"/>
    <dbReference type="EnsemblBacteria" id="ABL77537">
        <property type="protein sequence ID" value="ABL77537"/>
        <property type="gene ID" value="Tpen_0127"/>
    </dbReference>
    <dbReference type="GeneID" id="4600712"/>
    <dbReference type="KEGG" id="tpe:Tpen_0127"/>
    <dbReference type="eggNOG" id="arCOG05666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154405_0_0_2"/>
    <dbReference type="OMA" id="NPGSWKI"/>
    <dbReference type="OrthoDB" id="92828at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="220" mass="24663" checksum="7C5EA4D23C81AF87" modified="2007-02-06" version="1">MRVSCEKALFASDTHCRRGRKCRALEILASIAEREGAECLFVAGDLFDNFHFKASRRLLIEEFSKIIDVERLPAVFAASLSSSSHDPLLDSPLEEIIDGKRLLFSNGAVEVQVGGRQFIVIHGDRLVGSGVLAFLLNFVAERLGRKLYLEEAHRRVLGLGDEWLVMGHTHIPGIDREKRLVNLGSWKTSWKGGLPYWRKAKPTVLLVDDNGLRLEEVSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ6</accession>
    <name>A1RWJ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0166"/>
    <dbReference type="EnsemblBacteria" id="ABL77576">
        <property type="protein sequence ID" value="ABL77576"/>
        <property type="gene ID" value="Tpen_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0166"/>
    <dbReference type="HOGENOM" id="CLU_1631743_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="162" mass="17060" checksum="AF887FC65FE26815" modified="2007-02-06" version="1">MRLESYLGALVVFALLLAESLSAGNAVATIFLSALAMVFSASLLTGNASAVNVVASIYCVSLSVAAVLDFPLPVLLAELFTVLVARDLFSILAYGERAGTAYLLKVYLPLYSLAAIAVYVWLQVRKSTSAFASFQLVAASGFVALLVLYKVAGDLKRAVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL5</accession>
    <name>A1RWL5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="8">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751860.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0185"/>
    <dbReference type="EnsemblBacteria" id="ABL77595">
        <property type="protein sequence ID" value="ABL77595"/>
        <property type="gene ID" value="Tpen_0185"/>
    </dbReference>
    <dbReference type="GeneID" id="4600798"/>
    <dbReference type="KEGG" id="tpe:Tpen_0185"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_10_1_2"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="126"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="491" mass="52155" checksum="D8EC2317631B8665" modified="2007-02-06" version="1">MEAYLLVLFAAPLCASAFTALLRNARVGEILTVVSTLLLSAVSCLLMVETSTGRKFLLLGDEFIVDSLTSLMLVVISFVSLMVSLYSPKYLAYEVERGVVAREKVVLFYVLLNAFIFTMILVVTTNNIAIMWVALEATTIATAHLVATYRTAEAIEASWKYIILCSTGIAFGLYGVVTLYYTAYLAGIPAPLLWTSLVDHAKMLEAHSTMVKIAFTLALVGFGTKAGLAPFHTWLPDTYSEAPPYVSALLASILEGCAIYTLVRFYSVSVLAGVGAFAQTVLLVVGIASLFISSLHMLAVTDVNRLFALSSVEHMGIIACALGFGGYLGALAAVFHVVNHALVKSALFLSSGLVTLSYGTRKIEGIRGMMRSYPALGALVLAGAYAIIGGPPFGTFQSELLAIMAGVKSGNPFALVLFLAAIVVAFAALLVSCTNMVFGEPASSTEKYPHILKAPITILLLLSLLLGVYIPEPLRSCLENAGRSIVGGGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM4</accession>
    <name>A1RWM4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751869.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0194"/>
    <dbReference type="EnsemblBacteria" id="ABL77604">
        <property type="protein sequence ID" value="ABL77604"/>
        <property type="gene ID" value="Tpen_0194"/>
    </dbReference>
    <dbReference type="GeneID" id="4600803"/>
    <dbReference type="KEGG" id="tpe:Tpen_0194"/>
    <dbReference type="eggNOG" id="arCOG04225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_0_2"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="78043at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="189" mass="20399" checksum="D76B3297C0DC27FE" modified="2007-02-06" version="1">MQATCFEVRGLSIRLAQCDITEADTEAIVNAANSYLKHGGGVALAIVRKGGDVIQRESDEWVKRYGPVPEGEVAVTGAGKLKAKYVIHAVGPKYGDPLGDEKLARAISNSLLKAEELGLKSIALPAISTGVFGYPYRRCAEIMADVFLATAGKLKSLRTVLVCLWGSEAYEAFRSVFLEKLRDYISSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP2</accession>
    <name>A1RWP2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751887.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0212"/>
    <dbReference type="EnsemblBacteria" id="ABL77622">
        <property type="protein sequence ID" value="ABL77622"/>
        <property type="gene ID" value="Tpen_0212"/>
    </dbReference>
    <dbReference type="GeneID" id="4601805"/>
    <dbReference type="KEGG" id="tpe:Tpen_0212"/>
    <dbReference type="eggNOG" id="arCOG00187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_2"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="OrthoDB" id="13010at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="73"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="341"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="601" mass="66788" checksum="A9669BC81B2751A4" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP9</accession>
    <name>A1RWP9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="6" type="ordered locus">Tpen_0219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0219"/>
    <dbReference type="EnsemblBacteria" id="ABL77629">
        <property type="protein sequence ID" value="ABL77629"/>
        <property type="gene ID" value="Tpen_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0219"/>
    <dbReference type="eggNOG" id="arCOG04061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146475_0_0_2"/>
    <dbReference type="OMA" id="PRKMKQM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="13240" checksum="8D9A8D4AEB0B75E9" modified="2007-02-06" version="1">MMRLNREQRRMLERMGLVFKPIEGVQEVQIKLAGKTIIIRSPEVQVLEIKGGGKIYYVTGVEEEVPGEQQPQQLEISQEDIDLVVLRTGASPEEAKRALIESGGDIAKAILSLSQRKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ1</accession>
    <name>SYA_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="1">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alaS</name>
        <name type="ordered locus">Tpen_0221</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751896.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWQ1"/>
    <dbReference type="SMR" id="A1RWQ1"/>
    <dbReference type="STRING" id="368408.Tpen_0221"/>
    <dbReference type="PRIDE" id="A1RWQ1"/>
    <dbReference type="EnsemblBacteria" id="ABL77631">
        <property type="protein sequence ID" value="ABL77631"/>
        <property type="gene ID" value="Tpen_0221"/>
    </dbReference>
    <dbReference type="GeneID" id="4601814"/>
    <dbReference type="KEGG" id="tpe:Tpen_0221"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="7896at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000074515" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <sequence length="907" mass="102487" checksum="4B473AE5FCBC8563" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR9</accession>
    <name>A1RWR9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl32e</name>
        <name evidence="7" type="ordered locus">Tpen_0239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0239"/>
    <dbReference type="EnsemblBacteria" id="ABL77649">
        <property type="protein sequence ID" value="ABL77649"/>
        <property type="gene ID" value="Tpen_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0239"/>
    <dbReference type="eggNOG" id="arCOG00781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_3_0_2"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00810">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023654">
        <property type="entry name" value="Ribosomal_L32e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="159" mass="18186" checksum="5ED6C86F2B612C8D" modified="2007-02-06" version="1">MSTEDKGIASGETPKETVESVPEKRAKRKPALPEEKLRLLKLRLLISRHRPHFTRMNIWQFKRLEDVWRSPRHFLDNKIRLQRKGFPPMVKVGYRGPRAVRGLHPSGFEEVLVSSVKDLLGLDPAKHAIRISAKVGKKKRGEIIKKAEELGFRILNAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX04</accession>
    <name>A1RX04_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Valine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Valyl-tRNA synthetase</fullName>
            <shortName evidence="6">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">valS</name>
        <name evidence="10" type="ordered locus">Tpen_0325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751999.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0325"/>
    <dbReference type="EnsemblBacteria" id="ABL77734">
        <property type="protein sequence ID" value="ABL77734"/>
        <property type="gene ID" value="Tpen_0325"/>
    </dbReference>
    <dbReference type="GeneID" id="4600976"/>
    <dbReference type="KEGG" id="tpe:Tpen_0325"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_2"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="614"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL77734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="809" mass="92856" checksum="4129B00F21D51E23" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX05</accession>
    <name>A1RX05_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752000.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0326"/>
    <dbReference type="EnsemblBacteria" id="ABL77735">
        <property type="protein sequence ID" value="ABL77735"/>
        <property type="gene ID" value="Tpen_0326"/>
    </dbReference>
    <dbReference type="GeneID" id="4600977"/>
    <dbReference type="KEGG" id="tpe:Tpen_0326"/>
    <dbReference type="eggNOG" id="arCOG01218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_2"/>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="OrthoDB" id="67467at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="255" mass="29104" checksum="56FA3D634B2249B9" modified="2007-02-06" version="1">MPVEYDEELVNDLRQMFQALENPVSIKWFVDPGSECVYCDDTEQILNLVQQVSGGKVRVTRYTSKDPEAKKYSIDMFPAILIHGVDEWNVRFFGIPAGYEFGAFVEDIIDASTGRVNISPEIREILLKYVTKPTRIMIFVTPTCPYCPIAVRAAHRFAMVNKNIYGDMIEALEFSDLADRYGVYAVPKNVIQVNGEDKNEFEGAAPDPYFVAKILEAYGVEIPRSLQEAIAGIEAQYTEETYEDEELHHHHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX11</accession>
    <name>A1RX11_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752006.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0332"/>
    <dbReference type="EnsemblBacteria" id="ABL77741">
        <property type="protein sequence ID" value="ABL77741"/>
        <property type="gene ID" value="Tpen_0332"/>
    </dbReference>
    <dbReference type="GeneID" id="4601699"/>
    <dbReference type="KEGG" id="tpe:Tpen_0332"/>
    <dbReference type="eggNOG" id="arCOG03119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101250_0_0_2"/>
    <dbReference type="OMA" id="RMRPFER"/>
    <dbReference type="OrthoDB" id="82927at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="222" mass="24014" checksum="CC56EED2BCBD9CCF" modified="2007-02-06" version="1">MHPLLAWLLSIARGVGGYLGIFVISILGNLIPFIPIPYLVAVYLYAAYVPGSNPFLVGVVSGVGAGVGKLLVYLFSRGGARLFMSQESRERFEKIGKMLGNYGAIAVFLFAVTPSPDDAIIIPLGMMGYHPLKFFAAVTAGKIIISIATAFAGKAVFQLAGENFLESLATSIALFVVVMLLIYLLDWEAILSDLGSKGARGFLEDLRREGFSKYMKYRTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX49</accession>
    <name>A1RX49_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B-block_TFIIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752044.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0370"/>
    <dbReference type="EnsemblBacteria" id="ABL77779">
        <property type="protein sequence ID" value="ABL77779"/>
        <property type="gene ID" value="Tpen_0370"/>
    </dbReference>
    <dbReference type="GeneID" id="4600770"/>
    <dbReference type="KEGG" id="tpe:Tpen_0370"/>
    <dbReference type="eggNOG" id="arCOG04153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142666_0_0_2"/>
    <dbReference type="OMA" id="CYEGGYY"/>
    <dbReference type="OrthoDB" id="127641at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B-block_TFIIIC" evidence="2">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="137" mass="15855" checksum="19928B8687FCA52A" modified="2007-02-06" version="1">MAPASKVYAHEEDIEELEESSVQFQALERRVLELLREAGEKGVLQRELWKKLDVDSRKGLKILRKLESQGLIAKEQVVYKGRKTYVLKLAKEAEEVQIPGFLEEIPCFFCPFLHKCASGERDIYSCAILQEWLNKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXB8</accession>
    <name>A1RXB8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0439"/>
    <dbReference type="EnsemblBacteria" id="ABL77848">
        <property type="protein sequence ID" value="ABL77848"/>
        <property type="gene ID" value="Tpen_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0439"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="YHDNWLS"/>
    <dbReference type="OrthoDB" id="9947at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="158"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="671" mass="76133" checksum="AD161C04BB291473" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXC8</accession>
    <name>A1RXC8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ordered locus">Tpen_0449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0449"/>
    <dbReference type="EnsemblBacteria" id="ABL77858">
        <property type="protein sequence ID" value="ABL77858"/>
        <property type="gene ID" value="Tpen_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0449"/>
    <dbReference type="eggNOG" id="arCOG04183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179743_1_0_2"/>
    <dbReference type="OMA" id="CGYTIFE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="53" mass="6331" checksum="B22E7BDC761259C5" modified="2007-02-06" version="1">MAKVHELYEYDYKTGTIRLKNKKCPRCGSIMAHHLKPVERWHCGKCGYTEYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH0</accession>
    <name>A1RXH0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="10" type="ordered locus">Tpen_0493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752165.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0493"/>
    <dbReference type="EnsemblBacteria" id="ABL77900">
        <property type="protein sequence ID" value="ABL77900"/>
        <property type="gene ID" value="Tpen_0493"/>
    </dbReference>
    <dbReference type="GeneID" id="4601791"/>
    <dbReference type="KEGG" id="tpe:Tpen_0493"/>
    <dbReference type="eggNOG" id="arCOG01751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OMA" id="KPFYVRF"/>
    <dbReference type="OrthoDB" id="114541at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_L7Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL77900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="129" mass="13824" checksum="EA2641AC5E70EB7D" modified="2007-02-06" version="1">MSKKPFYVRFDVPPELAEKAYQALSLAREKGGKIKKGTNETTKAVERGLAKLVLIATDVDPPEVVAHLPLLCEEKKVPYVYVPSKERLGKAAGINVAAAAAAILEPGEAASLVDEIIKEVNNLKIKSGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH6</accession>
    <name>IF2P_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">Tpen_0499</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752171.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXH6"/>
    <dbReference type="SMR" id="A1RXH6"/>
    <dbReference type="STRING" id="368408.Tpen_0499"/>
    <dbReference type="PRIDE" id="A1RXH6"/>
    <dbReference type="EnsemblBacteria" id="ABL77906">
        <property type="protein sequence ID" value="ABL77906"/>
        <property type="gene ID" value="Tpen_0499"/>
    </dbReference>
    <dbReference type="GeneID" id="4601333"/>
    <dbReference type="KEGG" id="tpe:Tpen_0499"/>
    <dbReference type="eggNOG" id="arCOG01560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_2"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="OrthoDB" id="17053at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000335536" description="Probable translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <sequence length="601" mass="66557" checksum="997A90B8660B15B3" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXJ6</accession>
    <name>A1RXJ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752191.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0520"/>
    <dbReference type="EnsemblBacteria" id="ABL77926">
        <property type="protein sequence ID" value="ABL77926"/>
        <property type="gene ID" value="Tpen_0520"/>
    </dbReference>
    <dbReference type="GeneID" id="4601358"/>
    <dbReference type="KEGG" id="tpe:Tpen_0520"/>
    <dbReference type="eggNOG" id="arCOG00910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074702_1_0_2"/>
    <dbReference type="OMA" id="DVVYSIH"/>
    <dbReference type="OrthoDB" id="119044at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="210" mass="23468" checksum="EE032DFA8607A01B" modified="2007-02-06" version="1">MSPLRKKWLEILLNRIPRHPSPKIELEQYATPSTLAATLLWIAQEHFQDISGKKVLDLGCGTGRLGIGAALLGGIVVMLDLDFSAVSEAKSAAIRLGVYERVDLLVADVRLIPLREGILFDTVVENPPFGVHARGSDITFLSRAVMLAGTVYSIHKSSSVDFVKSYLEKMCGDIRVQVLFEERMCLPPEYPFHRKRRHCFNVAVIRVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK1</accession>
    <name>A1RXK1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0525"/>
    <dbReference type="EnsemblBacteria" id="ABL77931">
        <property type="protein sequence ID" value="ABL77931"/>
        <property type="gene ID" value="Tpen_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0525"/>
    <dbReference type="eggNOG" id="arCOG04414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257509_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="103" mass="11029" checksum="F0DC2DB2B62CCFAA" modified="2007-02-06" version="1">MHASCACVSKSGAPLKAVVRVLGTEEEVSIIYRSLKPETEEVPRYRSKVSLSVEGGSLTLTIVSSKVSSLRASLNTYSRILLALLEIQGVVGEGARLRDSPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN3</accession>
    <name>A1RXN3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">16S rRNA (pseudouridine-N1-)-methyltransferase Nep1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nep1</name>
        <name evidence="6" type="ordered locus">Tpen_0557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11633"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752228.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0557"/>
    <dbReference type="EnsemblBacteria" id="ABL77963">
        <property type="protein sequence ID" value="ABL77963"/>
        <property type="gene ID" value="Tpen_0557"/>
    </dbReference>
    <dbReference type="GeneID" id="4600521"/>
    <dbReference type="KEGG" id="tpe:Tpen_0557"/>
    <dbReference type="eggNOG" id="arCOG04122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_2"/>
    <dbReference type="OMA" id="VYVHTRN"/>
    <dbReference type="OrthoDB" id="72065at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00554">
        <property type="entry name" value="NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023503">
        <property type="entry name" value="Ribosome_NEP1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-xx" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="232" mass="25887" checksum="523E85CB56A0675B" modified="2007-02-06" version="1">MKKLVLVLADAGLELVPRELWSHPAVKSHAKRRGKNPGRMLLDISVHYAAMKTLNEYWKRGRPDIVHVSLLVAQDSVLNRLGYLHTVIHTYDGKLVELDPSMVVPRNYNRFVGLFEQLLEKGQVPPGSEKPLAKLRTGRNLGEVLKEMGVDAVYRLSEKGEPVKPLDLARRIAGSDVPAVIIGAFQRGEFSKEVLSIEAEEYSIFREALPAWTVVAEVVVSLEHVSVWGASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXR6</accession>
    <name>A1RXR6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydrogenase (NiFe) small subunit HydA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0591"/>
    <dbReference type="EnsemblBacteria" id="ABL77996">
        <property type="protein sequence ID" value="ABL77996"/>
        <property type="gene ID" value="Tpen_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0591"/>
    <dbReference type="eggNOG" id="arCOG02474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046107_1_2_2"/>
    <dbReference type="OMA" id="VPGCPIQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="9">
        <location>
            <begin position="54"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="10">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL77996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="423" mass="44902" checksum="566D7E4C096D8803" modified="2007-02-06" version="1">MSLKGISISRRDFLKMGGVAALLASLNWDELVRLAVAQAQSGSINIVWFEAQDCAGNTTALIQATEPDLIDVLGGSFHLVGPGNVKLAFHETVMPEWGEGALSIARAAAQGKLDPFVLVLEGSFPQDEKAGGPPGSDSYCYIGDENGKVISCVEWMRRLLPRAVAVVTMGNCASYGGLVANKVLERVPGLPSSSWSDSPTGAVGFFDDPIRGIKGLVSTLPEAEPFRRFITGQCTLKPGEIRPDCRPAMAVPGCPANGNGQLRALAALVLWAKGLLPLPELDKYWRPKFIFGNTVHEQCPRAGSYAAGDFRAYPGENSYRCLYAVGCKGPISNCPWNKLGWVNGVGGPTRTGGVCIGCTMPGFTDAYEPFYKPLQAPRVPSGLEGVAAIAALLAGVGLAYGASKSIEKRKEEVAKEIKEVKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT9</accession>
    <name>SYM_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="ordered locus">Tpen_0615</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752284.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXT9"/>
    <dbReference type="SMR" id="A1RXT9"/>
    <dbReference type="STRING" id="368408.Tpen_0615"/>
    <dbReference type="PRIDE" id="A1RXT9"/>
    <dbReference type="EnsemblBacteria" id="ABL78019">
        <property type="protein sequence ID" value="ABL78019"/>
        <property type="gene ID" value="Tpen_0615"/>
    </dbReference>
    <dbReference type="GeneID" id="4601321"/>
    <dbReference type="KEGG" id="tpe:Tpen_0615"/>
    <dbReference type="eggNOG" id="arCOG00810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="6590at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000331956" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="338"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <sequence length="565" mass="65322" checksum="A9C03C509CA634DA" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ2</accession>
    <name>A1RXZ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752337.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0670"/>
    <dbReference type="EnsemblBacteria" id="ABL78072">
        <property type="protein sequence ID" value="ABL78072"/>
        <property type="gene ID" value="Tpen_0670"/>
    </dbReference>
    <dbReference type="GeneID" id="4601036"/>
    <dbReference type="KEGG" id="tpe:Tpen_0670"/>
    <dbReference type="eggNOG" id="arCOG14961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998849_0_0_2"/>
    <dbReference type="OrthoDB" id="130719at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="124" mass="12685" checksum="D8B2DDE6D1EB1056" modified="2007-02-06" version="1">MLIVTLSVVALIGYFLYSVASGATNRPVLVQAGDALLTGSGTSYQVIVYLQNIGSTPADLTGANITIPDLNAGPAQLTCTPALLRNGDVAKCTSALTLTSAPTSAKTAIIETKYGAIKVTLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ5</accession>
    <name>A1RXZ5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752340.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0673"/>
    <dbReference type="EnsemblBacteria" id="ABL78075">
        <property type="protein sequence ID" value="ABL78075"/>
        <property type="gene ID" value="Tpen_0673"/>
    </dbReference>
    <dbReference type="GeneID" id="4601039"/>
    <dbReference type="KEGG" id="tpe:Tpen_0673"/>
    <dbReference type="HOGENOM" id="CLU_1575031_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="186" mass="19797" checksum="9710E16D34136570" modified="2007-02-06" version="1">MGRKALGSVTATLLLLLLSTITVLLAYPALLGSRGVARERLDTRTLLRLLHDLENGGIVELPVEAKLLGNASFIAINGKVAYAFNSAVIVFPQCESAPLSGQLFKVVREGSSCTVVFRPYLNLSAGEVVAVAAYGSGLYSRLNSTSVLRFFRGFVDELVIGQESYAVAAPLKLKVKVIEVRGVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY09</accession>
    <name>A1RY09_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752354.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0687"/>
    <dbReference type="EnsemblBacteria" id="ABL78089">
        <property type="protein sequence ID" value="ABL78089"/>
        <property type="gene ID" value="Tpen_0687"/>
    </dbReference>
    <dbReference type="GeneID" id="4601887"/>
    <dbReference type="KEGG" id="tpe:Tpen_0687"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803204_0_0_2"/>
    <dbReference type="OrthoDB" id="101728at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="346" mass="37218" checksum="1F053D8C08BBD665" modified="2007-02-06" version="1">MAHAYFAGLQLQGRWGVSSDDVLLARALGEGLGSYEAPPILFLPTVTYGVGNVGGERTTRVYIARYRSPGDYLALTRPLYLDADTAFRLAESIRARLPSTKIVASIATPKLSELRALASSFSKAVDAFEVDLGVLGILYGQRKSFEAFALDIVEEFVSAAPSPVVVKVSPGVPLSDAFLKLLVDAGVGGIVFSPHPVYAVGKSLFRVHSPLLSEVYSLIWARLITELNVSTAIVSDKPLEEIKEHDPITAFDIVLFDTALMFKHLKIAGTVENDLPLNWRSIATGLLPSVTLSEEEVCADVCPYGALNPLSAGETTDAVADSRCDFCGLCLSLCRTARLVRVLSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY54</accession>
    <name>A1RY54_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0732"/>
    <dbReference type="EnsemblBacteria" id="ABL78134">
        <property type="protein sequence ID" value="ABL78134"/>
        <property type="gene ID" value="Tpen_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0732"/>
    <dbReference type="HOGENOM" id="CLU_565781_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="486" mass="51244" checksum="9B31C9BCE91C80FE" modified="2007-02-06" version="1">MSCLRKAEYLYALGVSLLAGGWAARLYLDGRLEYASPVLLALPLLLLLSVSASLRRFRGKRLAIVAATSASISAPVLLVSAALLQSYTKEGRYPSPFIDEMLRNMGDGFFLVALAITTAVSAASLALFKALVTPEIRAFRKEGGRPLVEELVEAPQNAYAYSAIVAGLLLGYFQPLSLPALSVMPVLLMQPLPIQLSAFTGSLLAFLGVSVDPVLTVAALALYTEAWKRIWGVKTSRGAAVIISAGLYVLAGMLSFFTLFGAGFVFYQAVFAVLVLAAGYLLTSMEARGVLATPAMVLALSNLYLRAPLSPVSLEPLLPLVVASSWMAIPAFYSELSSEGLAEDEECSSLPVQAISVAVPATLVTLLYLSTGYSPQVLRVSAQPSYTVLSYALPVVALLASTVQQVASKRAVPGLVEPALLMFLHPAGLAFSLLVPREDAAPLALAAALLAVLHVALSKHGKTYREVASLFMVGVALGVVARLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY65</accession>
    <name>A1RY65_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rad51-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752410.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0743"/>
    <dbReference type="EnsemblBacteria" id="ABL78145">
        <property type="protein sequence ID" value="ABL78145"/>
        <property type="gene ID" value="Tpen_0743"/>
    </dbReference>
    <dbReference type="GeneID" id="4601150"/>
    <dbReference type="KEGG" id="tpe:Tpen_0743"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_2"/>
    <dbReference type="OMA" id="TFRIENI"/>
    <dbReference type="OrthoDB" id="30130at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="250" mass="26363" checksum="EBD543DB41A8EEB3" modified="2007-02-06" version="1">MEEVLAYLLGVGVPRVSRPARRVYEESARISTGVRSLDDLLEGGIEVGSITEFIGEFGAGKTQICHQLSVMVQLPKDKGGLNARALYVDTEGTFRPERIVQIARARGLDPEKTLENIIYARAYSLGGLEELLSKALAEVVKGDVGLVVLDEATRLVRASGLGAGERARAYAAIVSSLEAVAEAGSAVVVARQVVFGDGVRPAGGAALDGYAHLSVFLSKRGSAREARVLSSPWRGGVALFAVSEEGVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY85</accession>
    <name>A1RY85_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="4">DERA</shortName>
            <ecNumber evidence="4">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="4">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC</name>
        <name evidence="5" type="ordered locus">Tpen_0763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752430.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0763"/>
    <dbReference type="EnsemblBacteria" id="ABL78165">
        <property type="protein sequence ID" value="ABL78165"/>
        <property type="gene ID" value="Tpen_0763"/>
    </dbReference>
    <dbReference type="GeneID" id="4601084"/>
    <dbReference type="KEGG" id="tpe:Tpen_0763"/>
    <dbReference type="eggNOG" id="arCOG04320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_2"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="74992at2157"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="242" mass="26363" checksum="41C5FECC953EF040" modified="2007-02-06" version="1">MYYKNVIARPFPDPESLVEEVSRIIDHTNLRPEASEKELEKTCREAVDYGFYACCVPGFFVEKAVKIVDGAAKVVTVAGFPHGNSPRAVKVAEVKAAFEKGADEVDVVVNISLVKSGLLEEAVSEVQEILDVANESGGVLKVILETGYLTAEEVYRLGRELARIGVHFLKTSTGFGPRGATPEDILVMRRAVEGTRTKLKAAGGIRTGLQALFFYLLGVERIGTSSSLQIVNDLRALKELLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA2</accession>
    <name>A1RYA2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752447.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0780"/>
    <dbReference type="EnsemblBacteria" id="ABL78182">
        <property type="protein sequence ID" value="ABL78182"/>
        <property type="gene ID" value="Tpen_0780"/>
    </dbReference>
    <dbReference type="GeneID" id="4601841"/>
    <dbReference type="KEGG" id="tpe:Tpen_0780"/>
    <dbReference type="eggNOG" id="arCOG05517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157006_0_0_2"/>
    <dbReference type="OrthoDB" id="128268at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="134" mass="14678" checksum="F05049DD93AA7F7F" modified="2007-02-06" version="1">MKVSLTYTYIHAEKLSEPTGAQINVNVQLTFPTSMNIVGGELVAEFLANVTSVPAFFTVSLKGRISVSASEGELKELQEGLKNGRPDPQIIQMLSSNVLFETMLLLRELGIPPSLPLPPPPQPQRSEDGRHYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYB9</accession>
    <name>A1RYB9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0797"/>
    <dbReference type="EnsemblBacteria" id="ABL78199">
        <property type="protein sequence ID" value="ABL78199"/>
        <property type="gene ID" value="Tpen_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0797"/>
    <dbReference type="eggNOG" id="arCOG04279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141583_2_0_2"/>
    <dbReference type="OMA" id="CEPIVAT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="136" mass="14162" checksum="44FB980075D59428" modified="2007-02-06" version="1">MVEGNAEAPLLVSRTPITFLGGVDPFTGLVVEKGHPLYGQSVSGKILVFPYSKGSTVGSYILLRLSKRGLAPAGIVTSSADEVTVIGCLISNIPMMSGARLDAVSELLSGRTARLTVTRSDARLEILESGGSEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC6</accession>
    <name>A1RYC6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752471.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0805"/>
    <dbReference type="EnsemblBacteria" id="ABL78206">
        <property type="protein sequence ID" value="ABL78206"/>
        <property type="gene ID" value="Tpen_0805"/>
    </dbReference>
    <dbReference type="GeneID" id="4602136"/>
    <dbReference type="KEGG" id="tpe:Tpen_0805"/>
    <dbReference type="eggNOG" id="arCOG01811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082039_0_0_2"/>
    <dbReference type="OMA" id="ITEYRLW"/>
    <dbReference type="OrthoDB" id="4838at2266"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="31870" checksum="772B75292B6308C7" modified="2007-02-06" version="1">MPYIEMTPQRRLMLLAVGAMLGAVPLFLVASLFRGELLSSIQNAGGVYLVTSLRVNVLVTFSLVLFTLPYAFVDYLNRSFTRSVESVLPELFKGLAEAVRSGLTLPEALSSVAETLGGEVGKMLRQVVLLTEMGVTFQEAIARAFSRYRLPSLDRLGSILLTAYESGGKVIDALETSAQIFGAIRSYEEERATTINPHVLTIYAATILYVILSLTILYVFVMPLSRLQGIPGALGKINPGVYAAVMYYSGVMIAFFGGLIAGKMRHGKASAGLIHADIQVAIVAFSFLLAEKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF3</accession>
    <name>A1RYF3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752498.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0832"/>
    <dbReference type="EnsemblBacteria" id="ABL78233">
        <property type="protein sequence ID" value="ABL78233"/>
        <property type="gene ID" value="Tpen_0832"/>
    </dbReference>
    <dbReference type="GeneID" id="4601835"/>
    <dbReference type="KEGG" id="tpe:Tpen_0832"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_0_2"/>
    <dbReference type="OMA" id="AMTQQMK"/>
    <dbReference type="OrthoDB" id="49614at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="289" mass="32468" checksum="4B774A70021E0E6B" modified="2007-02-06" version="1">MDVASLIILFVVLLILAWIIASYIRIVPEYQRLVVLRLGRVVRIAGPGLVVLVPFIEQGIVVDLREQYIEVTKQTCITRDNAPVDIDFLIYFKVVDPKKSVVEVQDFRGAAVGIATTTLRAVVGDIELDQVLAKREYINEVLREKLDEVTARWGVKVTAVEIREILPPKEVQDAMIKQMSAERNRRAMVTEAEGKREAAVKVAQGEKEAMILRAEGEKQAAILKAEGQALALKYLDDQAKVIDSKTLLLQYFSTLREVASSPATKIVLPMELFKFLKPFEEYLEKSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF4</accession>
    <name>A1RYF4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752499.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0833"/>
    <dbReference type="EnsemblBacteria" id="ABL78234">
        <property type="protein sequence ID" value="ABL78234"/>
        <property type="gene ID" value="Tpen_0833"/>
    </dbReference>
    <dbReference type="GeneID" id="4601542"/>
    <dbReference type="KEGG" id="tpe:Tpen_0833"/>
    <dbReference type="eggNOG" id="arCOG04555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106161_0_0_2"/>
    <dbReference type="OrthoDB" id="139157at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="227" mass="23890" checksum="219B12AE6911C554" modified="2007-02-06" version="1">MSDLLDRYERALRKRGVGGRVTIAGSGVVSGGVYEKVTIAGSGVVDGDLEAESVSVSGSARFEGDVSAEKVRCAGSCRFSGSVKAESARFSGATIVEGELSSEELKVAGSLRAGRVKARDLRLSGSFRVGDVEAGWAEFRLSDDSEAGLVKATDVTVKSEKWGLLSGTFVSKLFGKKIPVFRVSRIEAENIVDVEGVVIEGDVNAKKVVLRRGGEVRGNISGSVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG0</accession>
    <name>A1RYG0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0839"/>
    <dbReference type="EnsemblBacteria" id="ABL78240">
        <property type="protein sequence ID" value="ABL78240"/>
        <property type="gene ID" value="Tpen_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0839"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064084_0_0_2"/>
    <dbReference type="OMA" id="EYDNFGL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="319" mass="35369" checksum="CD0656B9EDB3630A" modified="2007-02-06" version="1">MPRRKYTIRMFAVSLRKRGVDAVYSFPWKVSIVAFMANPPVLKEDIQALKETFSTLSSDRFFDVIEVQLLGDEAWRAVEGFVKASGVEVASGVQPLVLMQGFNPSSLVEAERKKAVSKLVEVVKTSAERGISKVAFSSGPDPGPENREAAKDALIKSLKEIAGEAKKFGVTVILETFDRDWDKKQLIGPIREAVEVAESVREEHGNFGLLWDLSHAPMLGEKPSDLKLAKSYLAHIHIGCAKRLPDGRLVDWHPGFYRPGAVNGVEDVKELLKVLLEIGYTGAVGFEVKPEEGQHWREPVEAAKGVLYEAFLRLVESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH0</accession>
    <name>A1RYH0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752515.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0849"/>
    <dbReference type="EnsemblBacteria" id="ABL78250">
        <property type="protein sequence ID" value="ABL78250"/>
        <property type="gene ID" value="Tpen_0849"/>
    </dbReference>
    <dbReference type="GeneID" id="4601974"/>
    <dbReference type="KEGG" id="tpe:Tpen_0849"/>
    <dbReference type="eggNOG" id="arCOG02102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_3_2"/>
    <dbReference type="OMA" id="GWVYRMY"/>
    <dbReference type="OrthoDB" id="114771at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="8546" checksum="41F6D85B2E47C564" modified="2007-02-06" version="1">MASRGYVPLALVPPGSVVRLVEVQGGHGVLRRLFELGILPGVEFRVVFNGAGPTVIERNGARLALGRGIAMRLLVEVVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI1</accession>
    <name>A1RYI1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752526.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0860"/>
    <dbReference type="EnsemblBacteria" id="ABL78261">
        <property type="protein sequence ID" value="ABL78261"/>
        <property type="gene ID" value="Tpen_0860"/>
    </dbReference>
    <dbReference type="GeneID" id="58787000"/>
    <dbReference type="KEGG" id="tpe:Tpen_0860"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340330_0_0_2"/>
    <dbReference type="OrthoDB" id="106207at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="114" mass="12879" checksum="A31702BC0BAB705C" modified="2007-02-06" version="1">MPSKVLTLREALKNPLRRRIVTYLLDNPGASIRQLSRSLGVSIGSLSGHLVILERVGLIREVRNSKRVELFINNEVLLHGITDEAQYSGEADGEVARQPREEGRERALQRREPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI4</accession>
    <name>A1RYI4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phage repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752529.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0863"/>
    <dbReference type="EnsemblBacteria" id="ABL78264">
        <property type="protein sequence ID" value="ABL78264"/>
        <property type="gene ID" value="Tpen_0863"/>
    </dbReference>
    <dbReference type="GeneID" id="4602206"/>
    <dbReference type="KEGG" id="tpe:Tpen_0863"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989090_0_0_2"/>
    <dbReference type="OrthoDB" id="126424at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="185"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="281" mass="31295" checksum="7328E1B24E34C524" modified="2007-02-06" version="1">MKVQLSRELALDVAAIVGPAVVSSLAMLIPIENFLSKYPFGVQYAWYYPWRGMFVALLLWIFSGATYSEKRYFLKKVFLGSSAAFVTFHYSQLWVVSRYVRVQLMPLFYLVGEHSPFFLDMGLVVLILTLLAFRKEVSTPSSQERRSESRGVVVGGWREIVLYALTIVGLLVFLLSLRFVLSTPVPLAVVSSWSMEPVLHVGDVVVVAGGNSYTLGDIVIYERGGELIVHRIVLSVNGKYVTKGDANPQADNIVLGKDAIYGKVQIVIPYIGALKLIFYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ3</accession>
    <name>A1RYJ3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_0872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PdaD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752538.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0872"/>
    <dbReference type="EnsemblBacteria" id="ABL78273">
        <property type="protein sequence ID" value="ABL78273"/>
        <property type="gene ID" value="Tpen_0872"/>
    </dbReference>
    <dbReference type="GeneID" id="4600354"/>
    <dbReference type="KEGG" id="tpe:Tpen_0872"/>
    <dbReference type="eggNOG" id="arCOG04490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114389_1_0_2"/>
    <dbReference type="OMA" id="IMEHTAY"/>
    <dbReference type="OrthoDB" id="98766at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="17249" checksum="A0E5FE7DD6211041" modified="2007-02-06" version="1">MLLPKKYFVTKGKGLSNVSPLMAFNNALREAGIHQLNLVPVSSILPPEVEEESPRRLPAGSIAFVVMSEKRAKGPARISTGISWARGKPHGYVIEFHDGNSSAETSSNLSAMWSEIRLRDVLELEEPRYLVEELEIPPGYYGSVVVALVFSDYSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL3</accession>
    <name>A1RYL3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0892"/>
    <dbReference type="EnsemblBacteria" id="ABL78293">
        <property type="protein sequence ID" value="ABL78293"/>
        <property type="gene ID" value="Tpen_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0892"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="556" mass="63159" checksum="80B9253573EE9BB1" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN0</accession>
    <name>A1RYN0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752575.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0909"/>
    <dbReference type="EnsemblBacteria" id="ABL78310">
        <property type="protein sequence ID" value="ABL78310"/>
        <property type="gene ID" value="Tpen_0909"/>
    </dbReference>
    <dbReference type="GeneID" id="4602122"/>
    <dbReference type="KEGG" id="tpe:Tpen_0909"/>
    <dbReference type="eggNOG" id="arCOG00614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099718_0_0_2"/>
    <dbReference type="OMA" id="SEFRAWY"/>
    <dbReference type="OrthoDB" id="118207at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="184" mass="19980" checksum="404EC72ACF0D4651" modified="2007-02-06" version="1">MRSYPLFYRGELLELLLSTIAVFLVFAAPYLPRLTLAGALVLFALAFLAYVPHELAHKFIAQYYGYPAKYSIVKELFLLTLVTAIPGIPLKLIAPGTVYIYAPLIDKRRNGIISAAGPATNIVLGLVALWSGGSLASSVASLSGWIALFNLVPFGPLDGKKIAEWNLAVWLALLAPALWLTFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN1</accession>
    <name>A1RYN1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752576.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0910"/>
    <dbReference type="EnsemblBacteria" id="ABL78311">
        <property type="protein sequence ID" value="ABL78311"/>
        <property type="gene ID" value="Tpen_0910"/>
    </dbReference>
    <dbReference type="GeneID" id="4602123"/>
    <dbReference type="KEGG" id="tpe:Tpen_0910"/>
    <dbReference type="eggNOG" id="arCOG00220">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_3_2"/>
    <dbReference type="OMA" id="FWMDNYA"/>
    <dbReference type="OrthoDB" id="43041at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="360" mass="40486" checksum="45DA6495879D78ED" modified="2007-02-06" version="1">MKLTRRQFLASLGAAAALASIGAYYWIFPKREERVLRVYNYSAYINPDIIKDFESKYGVKVIYDEYESAEEAYAKLQLGGGGYDVIVLTDQYVPQAVKKGLVAQLDKTRIPNLGNVDRVFFENNFDPGLRYAVPYAWGTTGIGVNRDYVAEGEIEGYEQLFDTKVFLPRHKGKVSMLEEFLEVVNAAKLYLGIPLNDWSEESKQRIIELLREQRDFLAGYYGASVYIPALAKGDLHAAHAWSGDVVQAQSENKSVEYVLPKEGAFVWIDFMVIPVNARSPDLAYEWINFLLDPAVAAKNSSYTYYPSPVKRELLEGLIGKDVLENPAVYPPSGTKLVQTYPLDESALKVVEEISTAVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ4</accession>
    <name>A1RYQ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752599.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0933"/>
    <dbReference type="EnsemblBacteria" id="ABL78334">
        <property type="protein sequence ID" value="ABL78334"/>
        <property type="gene ID" value="Tpen_0933"/>
    </dbReference>
    <dbReference type="GeneID" id="4600756"/>
    <dbReference type="KEGG" id="tpe:Tpen_0933"/>
    <dbReference type="eggNOG" id="arCOG07086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500260_0_0_2"/>
    <dbReference type="OrthoDB" id="11439at183924"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="544" mass="60495" checksum="51898B71179FEF62" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT9</accession>
    <name>A1RYT9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0969"/>
    <dbReference type="EnsemblBacteria" id="ABL78369">
        <property type="protein sequence ID" value="ABL78369"/>
        <property type="gene ID" value="Tpen_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0969"/>
    <dbReference type="eggNOG" id="arCOG03741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145188_1_0_2"/>
    <dbReference type="OMA" id="RCIEAEC"/>
    <dbReference type="OrthoDB" id="116310at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="12835" checksum="FA9F76C05B70BFAF" modified="2007-02-06" version="1">MGHVRVKAKVCDAQGARCIEAECLVDTGATLSVIPRSLARELGVEVVDRDRVETGAGVVEVDRGVALIEVEGRKTVSNVWISDVTDKVLIGAVTLELAGLKLDPRTGRLEPAQLLLHRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU0</accession>
    <name>A1RYU0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0970"/>
    <dbReference type="EnsemblBacteria" id="ABL78370">
        <property type="protein sequence ID" value="ABL78370"/>
        <property type="gene ID" value="Tpen_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0970"/>
    <dbReference type="HOGENOM" id="CLU_2476203_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="87" mass="9616" checksum="5DF66E072BF6CD6B" modified="2007-02-06" version="1">MSVRASRLLVAVEIAFAALVLLLFWAPWLDDGEVSARLLEEKGVVDGTVRNGTVVCEYKVRWAPFGRVALSCEGGPYYVTFWGQVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV2</accession>
    <name>A1RYV2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1156 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752647.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0982"/>
    <dbReference type="EnsemblBacteria" id="ABL78382">
        <property type="protein sequence ID" value="ABL78382"/>
        <property type="gene ID" value="Tpen_0982"/>
    </dbReference>
    <dbReference type="GeneID" id="4600456"/>
    <dbReference type="KEGG" id="tpe:Tpen_0982"/>
    <dbReference type="eggNOG" id="arCOG00889">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007795_2_0_2"/>
    <dbReference type="OMA" id="TVIAWIW"/>
    <dbReference type="OrthoDB" id="2122at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009537">
        <property type="entry name" value="DUF1156"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06634">
        <property type="entry name" value="DUF1156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1156" evidence="2">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113965" checksum="3B83BA05D89C8AA7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW5</accession>
    <name>A1RYW5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0995"/>
    <dbReference type="EnsemblBacteria" id="ABL78395">
        <property type="protein sequence ID" value="ABL78395"/>
        <property type="gene ID" value="Tpen_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0995"/>
    <dbReference type="eggNOG" id="arCOG02734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032976_0_0_2"/>
    <dbReference type="OMA" id="SITHAPY"/>
    <dbReference type="OrthoDB" id="118295at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="121" mass="12122" checksum="3C519BB65C91500B" modified="2007-02-06" version="1">MPPLPPPPPGTLRVAAGTDTADGLNAPVSARFARTPFLTIVDIVDGRATRVEPMPNAFASGAGGVGAAVGQWLLSSGVSVVVAPSLGPNISMILGQAGVRVEVVPPGVPLGEALKRLGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW6</accession>
    <name>A1RYW6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0996"/>
    <dbReference type="EnsemblBacteria" id="ABL78396">
        <property type="protein sequence ID" value="ABL78396"/>
        <property type="gene ID" value="Tpen_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0996"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_1_0_2"/>
    <dbReference type="OMA" id="GIGCVVI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="288" mass="30134" checksum="815E8FCA48B07921" modified="2007-02-06" version="1">MEVVVASGKGGTGKTFFSSNLAVYLRDRGGCVAADADVEAPDFLLALGGARRVLWREEFRGVRRPVVDYSACVKCWACVDACQFNAIRRGPEGPVVDYDRCEGLGTCAFVCPAGAIGFAEERAGEIYAAETEHGVTVVTGDLELGGGASGRLVYELKERARRLSSGAARYVVVDAAPGIGCPVVSSVAGADLLVVVVEPTPQSAKGAARLLEVAGALRVKAVAVVNKYDLNPSYAARLEGELGVDVAGRIPYDEAVARSYAEMKPLIVAYPSSKAARALLDVFSSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX1</accession>
    <name>A1RYX1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Tpen_1001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1001"/>
    <dbReference type="EnsemblBacteria" id="ABL78401">
        <property type="protein sequence ID" value="ABL78401"/>
        <property type="gene ID" value="Tpen_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1001"/>
    <dbReference type="eggNOG" id="arCOG00462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_2_1_2"/>
    <dbReference type="OMA" id="RNMIRVI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="74"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABL78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="253" mass="28478" checksum="05DEE303B6B6EE1F" modified="2007-02-06" version="1">MRKVWLFKDFSSIPPGVRGKAFKVEARCPSVGYRGEEYFEEVARRLAEWYRRRGRDFPWRHTRDPYVILATEFLLQRTRAETVAKVFEEFFSRYPSPESLANADPEELRKFFSRLGLVRRADALREAAREIVERHGGSVPRSKEELLKLKGVGPYIASAVLCFAYSAPVPVVDTNVERVLGRAAGASSREEAEAFLERLLRHGNPREISLALIDLGALVCTRKPKCPECPLSDLCSYRGSGRPGAQCAGGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY5</accession>
    <name>A1RYY5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1015"/>
    <dbReference type="EnsemblBacteria" id="ABL78415">
        <property type="protein sequence ID" value="ABL78415"/>
        <property type="gene ID" value="Tpen_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1015"/>
    <dbReference type="eggNOG" id="arCOG03760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036736_0_0_2"/>
    <dbReference type="OrthoDB" id="120286at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="260" mass="29633" checksum="702DCF3FD4C7CE4A" modified="2007-02-06" version="1">MDEIEEYARRLGGLIREKGRLTVDEILDWGQREGLNSLTLYMVVESLLEDASFKPSGERRVIDSYLNLELPEKVEYVAAKAEEKAGEVPAKAPPRPREEKGRKPKKQPPRVKPSRERSLLEFFGEEREEPSREEPVERGEEGGEEPERREEPAPEPAAEPRASVGVQEVDCSEVSDLLGNEAYERALRYLCTYWSIGLLRLMDDLIRMGVKEPRKFLAELAKRGLIEVTELEVVNAKEKLLKLSECFGKDRSTLVDLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ25</accession>
    <name>A1RZ25_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752720.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1055"/>
    <dbReference type="EnsemblBacteria" id="ABL78455">
        <property type="protein sequence ID" value="ABL78455"/>
        <property type="gene ID" value="Tpen_1055"/>
    </dbReference>
    <dbReference type="GeneID" id="4601441"/>
    <dbReference type="KEGG" id="tpe:Tpen_1055"/>
    <dbReference type="eggNOG" id="arCOG00154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_0_2"/>
    <dbReference type="OrthoDB" id="22918at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="418" mass="45529" checksum="2686FBFCB5E262FC" modified="2007-02-06" version="1">MAAQEKGKKGVNKLLIAVAVLVIVALAAVALYPMFAPKPAPKQVKITIWTAWTGGEYDALKAVIDDFRAKNPNYQIDIVNVPFDQLKNKVIQAVPVGEGPDLFTGPHDWTGELVQAGALVDITDKVSAFKGEYMESALQGVTLKGKIYGLPESIKLPALIVNKKLLATPPKTLDELWSIMDQFKAKGMYGLAYDVQNAYFSSCWFYGLGAYYLDPNTLETALDSPGAVQAFQIIAKFSKYLPPDISYDMMTNLFMNGKAAMAINGPWWIGDLKKAFGENLADIEITLIPAIDPAHPARPFMTVEAVFVTKNAAERGVLDEAIALAHYITGEASVKLAKMAGHVPTWKNAMKDPAVSGDKVISAFFKQAEYGVPMPNVPEVAQMWNVVPKYISQVYQGQLSPQDAAKAAAQELRAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ30</accession>
    <name>A1RZ30_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752725.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1060"/>
    <dbReference type="EnsemblBacteria" id="ABL78460">
        <property type="protein sequence ID" value="ABL78460"/>
        <property type="gene ID" value="Tpen_1060"/>
    </dbReference>
    <dbReference type="GeneID" id="4601446"/>
    <dbReference type="KEGG" id="tpe:Tpen_1060"/>
    <dbReference type="eggNOG" id="arCOG00168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_2"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="OrthoDB" id="86965at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="68"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="29588" checksum="E5B60780411789A8" modified="2007-02-06" version="1">MNRRRLVNTAVAAGATVFSATVFLLIALLVAKPLYAGASVVLRRGISFFTEPPAPPGVGETGGVIYALLGTLLMTLIAVLVSSPLGVLTGIYVSEYPRDPLARLAEHASQFLSEVPSVLLGVFVYGAVVVYTKSPSLLAGALSLSLVVTPYIVVHTKEILSSIPFAYREAAFALGLPKWKTVLLVLLPMNLRGIASSLLAAYFRALGETAPVLFTAGAAFNGFYGLLGPSSTLSLLVWTYGQSPFENWQELAWGAAFILVAFTLAASIALRVSVREVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ60</accession>
    <name>A1RZ60_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase system, phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752755.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1091"/>
    <dbReference type="TCDB" id="8.A.8.1.6">
        <property type="family name" value="the phosphotransferase system hpr (hpr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78490">
        <property type="protein sequence ID" value="ABL78490"/>
        <property type="gene ID" value="Tpen_1091"/>
    </dbReference>
    <dbReference type="GeneID" id="4602131"/>
    <dbReference type="KEGG" id="tpe:Tpen_1091"/>
    <dbReference type="eggNOG" id="arCOG04543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_2_2"/>
    <dbReference type="OMA" id="APHGIHT"/>
    <dbReference type="OrthoDB" id="124925at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="9826" checksum="FFFC9D4C88E67BE9" modified="2007-02-06" version="1">MKTLKVKVSNRSGLHARPAAVFVQTARKFKSRITVRKLDKAADSKNILQLLALGVDMGDEIEIVAEGPDEEEAIAELGKLLTEVLPSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ88</accession>
    <name>A1RZ88_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752783.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1120"/>
    <dbReference type="EnsemblBacteria" id="ABL78518">
        <property type="protein sequence ID" value="ABL78518"/>
        <property type="gene ID" value="Tpen_1120"/>
    </dbReference>
    <dbReference type="GeneID" id="4600862"/>
    <dbReference type="KEGG" id="tpe:Tpen_1120"/>
    <dbReference type="HOGENOM" id="CLU_720844_0_0_2"/>
    <dbReference type="OrthoDB" id="135437at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="383" mass="41949" checksum="82EC95B82EE0CA5C" modified="2007-02-06" version="1">MKTRIVGLALVALLLLAPLQIALAGTDTSAEILVSNAKRLQQLVHYRNTVISSTLNVTSIGSNWTLILNLTLQADLYLNASIQALNAGNYTEAKIYAIKAINTYGQVLELQEELAEEYDIHFKLEGEIEEGYANATKLGVNASIAINRTALTLQLEVLENRVDLLLEVLGKVNTSLYNVSGAISLLQEAKLLLEEAEAKLEAGNITVPELAKTLAVVKKILGLVNAELHRASLALTVNRAMKLGLLKKNETLPLNMSPLINHTKIKVKGLKGNLTERLEELEEELNETAAKIAAGNVSAKEVKKAGKQLEKELKEVEKKLNEVFSRVENKIATKAKEKGGWKHEIKVEVKEKHGQGPQPWTPSVTQGESEEEHEEGEGRGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB6</accession>
    <name>A1RZB6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="5">OPRT</shortName>
            <shortName evidence="5">OPRTase</shortName>
            <ecNumber evidence="2 5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrE</name>
        <name evidence="7" type="ordered locus">Tpen_1148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752811.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1148"/>
    <dbReference type="EnsemblBacteria" id="ABL78546">
        <property type="protein sequence ID" value="ABL78546"/>
        <property type="gene ID" value="Tpen_1148"/>
    </dbReference>
    <dbReference type="GeneID" id="4600954"/>
    <dbReference type="KEGG" id="tpe:Tpen_1148"/>
    <dbReference type="eggNOG" id="arCOG00029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_2"/>
    <dbReference type="OMA" id="MKAYQRQ"/>
    <dbReference type="OrthoDB" id="117225at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="5">
        <location>
            <begin position="112"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="18744" checksum="B00EDB3FF2ECC1B9" modified="2007-02-06" version="1">MIEEILWEIGAVKTGEFRLTSGKVSNVYIDLRKLPSHPQAFRRVVEALAAVARTIEFDAVCGIAVGGLPIATALAYTLGKPLIYARREKKAHGTMKQLEGDYARGMKVLLVDDVATTGGTLLDIARLLKSEGLEVVEALVVVDREEGASEALRSEGLRLRSLTTLKKVLSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC4</accession>
    <name>A1RZC4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752819.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1156"/>
    <dbReference type="EnsemblBacteria" id="ABL78554">
        <property type="protein sequence ID" value="ABL78554"/>
        <property type="gene ID" value="Tpen_1156"/>
    </dbReference>
    <dbReference type="GeneID" id="4602158"/>
    <dbReference type="KEGG" id="tpe:Tpen_1156"/>
    <dbReference type="eggNOG" id="arCOG07159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_2"/>
    <dbReference type="OMA" id="DIQACLF"/>
    <dbReference type="OrthoDB" id="102938at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="226" mass="25116" checksum="68C78737ED81CEF3" modified="2007-02-06" version="1">MRVKASFVWDFDGVIVETPHEEAWAAACREWGLEGFDHEFYEEYVSGRPRLEGARNVLSMLGGLSPSQPDFEKRVAEFAERKTEIYLRLVGEGRYRVRRDVVNFISYARREGIPQVLASASRNVLVVLRKEPSLLGLFDADVSGSGRSKDEVLSSALRVVRERWPAVACNVLFEDSPAGVEAGRLLGFKVVGCFNPRLAGSGANYTVESFEGLNPLDVLRKVGCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ4</accession>
    <name>A1RZJ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH DNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752889.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1226"/>
    <dbReference type="EnsemblBacteria" id="ABL78624">
        <property type="protein sequence ID" value="ABL78624"/>
        <property type="gene ID" value="Tpen_1226"/>
    </dbReference>
    <dbReference type="GeneID" id="4601723"/>
    <dbReference type="KEGG" id="tpe:Tpen_1226"/>
    <dbReference type="eggNOG" id="arCOG04189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182708_0_0_2"/>
    <dbReference type="OMA" id="YGWLVFF"/>
    <dbReference type="OrthoDB" id="130936at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10332" checksum="01A1B13821389191" modified="2007-02-06" version="1">MSKDQLVGWALALISVVVILLYGWLVFFTSWDVLVLKLTGFAAVAGVFGILAWIGYTLATTPPPKPIEEIEKEIEEELKRLEQESQQAQQGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZJ5</accession>
    <name>A1RZJ5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribulose bisphosphate carboxylase</fullName>
            <shortName evidence="3">RuBisCO</shortName>
            <ecNumber evidence="3">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbcL</name>
        <name evidence="6" type="ordered locus">Tpen_1227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuBisCO large chain family. Type III subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752890.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1227"/>
    <dbReference type="EnsemblBacteria" id="ABL78625">
        <property type="protein sequence ID" value="ABL78625"/>
        <property type="gene ID" value="Tpen_1227"/>
    </dbReference>
    <dbReference type="GeneID" id="4601724"/>
    <dbReference type="KEGG" id="tpe:Tpen_1227"/>
    <dbReference type="eggNOG" id="arCOG04443">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031450_3_1_2"/>
    <dbReference type="OMA" id="IHGHPDG"/>
    <dbReference type="OrthoDB" id="9533at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08213">
        <property type="entry name" value="RuBisCO_large_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01133">
        <property type="entry name" value="RuBisCO_L_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017712">
        <property type="entry name" value="RuBisCO_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020878">
        <property type="entry name" value="RuBisCo_large_chain_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03326">
        <property type="entry name" value="rubisco_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00157">
        <property type="entry name" value="RUBISCO_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="4">
        <location>
            <begin position="141"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="366"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="443" mass="48972" checksum="64E48C8F1DAF8288" modified="2007-02-06" version="1">MPEEFEPYGEFVVKSYLPDPDKDVIVTFRVTPSEGFTIEDAAGGVAAESSVGTWTTLYQWYDKSRIDRLKGKAYYMESLGDGSYILRVAYPVELFEEGNMPAFLASVAGNIFGMRRVRSLRVEDIYLPEAFLKHFKGPSQGVEGVRGKLKIWGRPIIGTVPKPKVGYSPEEVEKLAYEILVGGMDFVKDDENLAGPSYCRFEERAKAIMKAIDRAEKETGERKAWLANITADVREMERRLKLVAELGNTHVMVDVVIAGWSSLTYVRDLAADYKLAIHGHRAFHAAFTRNPYHGVSMFTLAKLYRIIGVDQLHVGTPEVGKLEAKAVDVIRMARLLREQTYKPDIEDGLHMQQPFPGIKPAFPVSSGGLHPGTLPAVIKAMGVDTVIQVGGGVVGHPDGPRAGAAAARQAVEAYLEGVPLQEYAKTHRELARALEKWGQVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZP6</accession>
    <name>A1RZP6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752941.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1278"/>
    <dbReference type="EnsemblBacteria" id="ABL78676">
        <property type="protein sequence ID" value="ABL78676"/>
        <property type="gene ID" value="Tpen_1278"/>
    </dbReference>
    <dbReference type="GeneID" id="4600745"/>
    <dbReference type="KEGG" id="tpe:Tpen_1278"/>
    <dbReference type="eggNOG" id="arCOG02039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848933_0_0_2"/>
    <dbReference type="OrthoDB" id="141088at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="327" mass="35872" checksum="5937BA13767C5CD4" modified="2007-02-06" version="1">MELRFVKTLLDAGKTYFESKGVTSFDLEKFAEMLRLASSLRKVDAKTIADALGLHPSDASGYLRLGWHSGLLSYSGKAYYATRLARDVAGACSEPGSRGCVEAVRRVMLSWYPLRVFLSYLCSRRSFNAMDAVRELGGEMRYWNGVMMRLGLPVSPAGGGEAPEKPFNSYVVSALFERMVDQLYVGCEHLREPAEYWYVRGREDEPVVAVAVAHVVYTYREPVLVTPRVDDEGLGLVVRALREAGPGRSATLVTVKGQGVARYPGLDVEFTEKPLHANIYASEGEVLLSSANLTGDSLYRSVEFGVVVKSSPSLLAVVDDLLPGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZR2</accession>
    <name>A1RZR2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752957.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1294"/>
    <dbReference type="EnsemblBacteria" id="ABL78692">
        <property type="protein sequence ID" value="ABL78692"/>
        <property type="gene ID" value="Tpen_1294"/>
    </dbReference>
    <dbReference type="GeneID" id="4600648"/>
    <dbReference type="KEGG" id="tpe:Tpen_1294"/>
    <dbReference type="HOGENOM" id="CLU_1763954_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="147" mass="15504" checksum="6AF6085C23079C08" modified="2007-02-06" version="1">MAGGAVVAAFRGRAPGRCRELSEPVNGWVWAECRSVQDLYAGLAEEARAGRQPSPVATPYGVLDPLDPRLEEACTYGRVGGAVKLKPSSGVADALKALLEVGATYAKVNGSIVEAEIPETPLEELLARGLVPLSWQKPARVELARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZT4</accession>
    <name>A1RZT4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated RAMP protein, Cmr6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1317"/>
    <dbReference type="EnsemblBacteria" id="ABL78714">
        <property type="protein sequence ID" value="ABL78714"/>
        <property type="gene ID" value="Tpen_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1317"/>
    <dbReference type="eggNOG" id="arCOG02661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053305_3_0_2"/>
    <dbReference type="OMA" id="PTRPENF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010172">
        <property type="entry name" value="CRISPR-assoc_prot_TM1791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39965">
        <property type="entry name" value="PTHR39965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01898">
        <property type="entry name" value="cas_TM1791_cmr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="31758" checksum="CBEEC0B0038E2248" modified="2007-02-06" version="1">MDLLGLVYGYVDELLKNPEAEKEELRRRLIERIVENYSRGRELDEKLRLSRERLESLAAGLALAGFHVFVVDAKLSTMGAVGVSHGVLRSVFEVGVSWDHVLDLPFIPGSSVKGAVRAVAERASRDDADVLFGRGGDSGWAGLLLFFDAYPVEAGDRLLEPDIVTPHYSRGGRPVRFEYEVEPVPVAHVSIAPGAVFRFVVAVEPGGGVLHEEVDRALANICGRLGVQGGGPASLLLGLLEYALASGVGARTSQGYGRFEVVSRSAVINGSEHRTPLRVKPARARRGRSTRPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY4</accession>
    <name>A1RZY4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1367"/>
    <dbReference type="EnsemblBacteria" id="ABL78764">
        <property type="protein sequence ID" value="ABL78764"/>
        <property type="gene ID" value="Tpen_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1367"/>
    <dbReference type="HOGENOM" id="CLU_1665591_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="158" mass="17704" checksum="91408A353DE47FE2" modified="2007-02-06" version="1">MVARRAVVDLLAFFGCRHPSPGCSFNAELLDYLVRIGVTVHFVSRVQVEKYNWGSCAGEKARLLAWLRKGKELGHGAREERVAGEVVRGGVHRDEYLDLCAGVAKAFQECSADLALLCSGKTMDVDELLLKLRRVAEVELEALSFPDVYLLRKVDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY9</accession>
    <name>A1RZY9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylglycerone-phosphate synthase</fullName>
            <ecNumber evidence="2">2.5.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.26" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1372"/>
    <dbReference type="EnsemblBacteria" id="ABL78769">
        <property type="protein sequence ID" value="ABL78769"/>
        <property type="gene ID" value="Tpen_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1372"/>
    <dbReference type="eggNOG" id="arCOG00337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_2_3_2"/>
    <dbReference type="OMA" id="PRCHDEV"/>
    <dbReference type="OrthoDB" id="77247at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="465" mass="52023" checksum="112AAC43E13E055C" modified="2007-02-06" version="1">MGGERVPKREVLEELGRLLGDRLSTSEEVLRLYSRDYWPLALLKEVRGEALPRPLAVAWPESAEEVAAVVRVLARHGVPFVPYAGGSGVIGGTICEGCVVIDVKRMNRVLWFSERDAVAVAESGVLLRKLEEYLNARGFTLRHIPQSYPEAALGGLVATMSTGQFSTKYGGIEELVLDLEAVMPDGRIAPFRRNLVPRAATGPDFKRLLIGSEGQLGVITKVALKVFPLPRHSWMRAYAFPSFEKGLEAMREVMLSGATPAVARLYDKDDSAARFHDARDILLLIVEEAEEELLEAKRRVIERILSRHGAVDAGEEHVEKWLKTRFDVISELKKLVVPLNLWFETIETAALWSNLPRVYAEFKKRVKSVPGVYAVLAHASHFYTTGACIYFTLTYDAREDVYWRMWETAVRVLLENGATISHHHGVGLLRAKWVGEELGDTLEYLKRVKKALDPGNLSNPGKWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ3</accession>
    <name>A1RZZ3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein cinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1376"/>
    <dbReference type="EnsemblBacteria" id="ABL78773">
        <property type="protein sequence ID" value="ABL78773"/>
        <property type="gene ID" value="Tpen_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1376"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_5_2"/>
    <dbReference type="OMA" id="IGNVIVM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="273" mass="29601" checksum="4C94CA87E7B4F44F" modified="2007-02-06" version="1">MPLAFQSVKGSAWILSVGNELLIGRVVNTNAAWLAQRLTLLGYAVRRIVVVPDVEEEIAGAFRDALGSADVVVSTGGLGPTPDDVTNFALAKALGRPAEVNAEALRMVEEKYARRGYPMTPEREKMAVMPRGARPLPNPVGTAPGILVEEGSKIVVCLPGVPSEMEAIFLEHVEPLLRSRGPPHFYAERVVRVKGVPESDVAPVVKKALKLSELVYVKSHPRGFEVDAPVLEIHVYGGSEKPGEAESEVERVAAFVAEEIRRSFPEKAQVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ8</accession>
    <name>A1RZZ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753043.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1381"/>
    <dbReference type="EnsemblBacteria" id="ABL78778">
        <property type="protein sequence ID" value="ABL78778"/>
        <property type="gene ID" value="Tpen_1381"/>
    </dbReference>
    <dbReference type="GeneID" id="4600369"/>
    <dbReference type="KEGG" id="tpe:Tpen_1381"/>
    <dbReference type="eggNOG" id="arCOG03408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070505_0_0_2"/>
    <dbReference type="OMA" id="RMEEWAD"/>
    <dbReference type="OrthoDB" id="67961at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="345" mass="38489" checksum="9F38B45D642C5F8D" modified="2007-02-06" version="1">MGWERVRLEFARGVSVRFADRDEALRQVERVAERGTRFPVVVYGPEGCGKTALFRQAVEILKSHGYGVVYVNPAASVKDEKVVSTEDVKEIVGATVGLLEPAAATLAEKAFELVSRLLSVKRRVAVILDEVFQAVGPERAEVYVKALLDAIEYPSARYESFVAIIGSSEGTTRARVARHSWATIRVLWNMAREGFKELYDQIPGPGLDFDSAWRLTGGNPRYLAMLYEHGWDAGSLVEEVVSARRLKAFASRLTPLQLEALSEAVEDPDRLLEYLKRGEPSIERLVDSLVELNLVAEIPDRGYGWLDKAPPEKDPSLGIGRFYAWQTPIHREAVRRALSGVHERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZZ9</accession>
    <name>A1RZZ9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="2">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Spermidine synthase</fullName>
            <shortName evidence="2">SPDS</shortName>
            <shortName evidence="2">SPDSY</shortName>
            <ecNumber evidence="2">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speE</name>
        <name evidence="5" type="ordered locus">Tpen_1382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753044.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1382"/>
    <dbReference type="EnsemblBacteria" id="ABL78779">
        <property type="protein sequence ID" value="ABL78779"/>
        <property type="gene ID" value="Tpen_1382"/>
    </dbReference>
    <dbReference type="GeneID" id="4600370"/>
    <dbReference type="KEGG" id="tpe:Tpen_1382"/>
    <dbReference type="eggNOG" id="arCOG00050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_2"/>
    <dbReference type="OMA" id="WIPSFGY"/>
    <dbReference type="OrthoDB" id="77175at2157"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="2">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="305" mass="33950" checksum="07988095420E6955" modified="2007-02-06" version="1">MHSSYILFLGIVNRAGWVAVGGEEGFEGVYIVEPAGRHLRLLFKVSKVYALEKSPYQEVVLAELEGFGRALLLDKFIQSTEKDEYMYHELLVHPAMAAHPAPERVLVLGGGEGATLREVLKHGTVKKAVMVDIDPVVVEFSKKRLGHMHLGSFDDPRVEVVIADGKDYVRQAPSGYFDVVIMDLTDPYASEIAKPLYSPEAFAEVKRILKPDGVVATQAGSSYFYPEEYRSVLESVKKSFAHVSEYWFWVPSFGVNVNFIVASDAYRLEDVVGLVDARLAERGVKTRLLTGRLLEGLLKIGVLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S015</accession>
    <name>A1S015_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753060.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1398"/>
    <dbReference type="EnsemblBacteria" id="ABL78795">
        <property type="protein sequence ID" value="ABL78795"/>
        <property type="gene ID" value="Tpen_1398"/>
    </dbReference>
    <dbReference type="GeneID" id="4600462"/>
    <dbReference type="KEGG" id="tpe:Tpen_1398"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_999731_0_0_2"/>
    <dbReference type="OrthoDB" id="92502at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="69"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="278" mass="30737" checksum="42D558BDB9E921E9" modified="2007-02-06" version="1">MESSRSTRVEGLRGLLLEFEAAALAGLKNYFRYAAWLVSDIVTTPAWLILLIVPILLFLPKERWSDQVVLNTLFWGMILWDVVGAGLWSFGMTIRREQQTGTLEFLLITNANRAVLFSRSLYSRLISLPLSILYTYAIFTAIFGVNVLLLEPLHAVAALFVGLVASMGFGLLYGAAVFRFKNVGPLTSILQFVFLGLCGVFFPVTALPEPLRIPAYLLPFTYTGDLLRHHAAGTETLLPVGLEWIVFLAETAAYLVAGFASLALVEKNLKRKGLLGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S022</accession>
    <name>A1S022_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753067.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1405"/>
    <dbReference type="EnsemblBacteria" id="ABL78802">
        <property type="protein sequence ID" value="ABL78802"/>
        <property type="gene ID" value="Tpen_1405"/>
    </dbReference>
    <dbReference type="GeneID" id="4601819"/>
    <dbReference type="KEGG" id="tpe:Tpen_1405"/>
    <dbReference type="eggNOG" id="arCOG07453">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171558_0_0_2"/>
    <dbReference type="OMA" id="INWQKFL"/>
    <dbReference type="OrthoDB" id="112137at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="110" mass="12399" checksum="D8682F2538325DB5" modified="2007-02-06" version="1">MSASLSEPPEPLEIKEKIRALRSALGAGLEADRLAVWTGNMLARYLWGAWGAELKRAGFTWQSFMSLLKLHTDDVVAWALRDNLSWGELVRRVISSVEGRRRSDLSRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S024</accession>
    <name>A1S024_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1407"/>
    <dbReference type="EnsemblBacteria" id="ABL78804">
        <property type="protein sequence ID" value="ABL78804"/>
        <property type="gene ID" value="Tpen_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1407"/>
    <dbReference type="eggNOG" id="arCOG07510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198716_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8833" checksum="81D2F83819B86D53" modified="2007-02-06" version="1">MVFKLVQKSLVSMLEKHHPLYQQHASIKRKLEADSQLMPEAIHGLAALYLEEEDFTCFAAKKLYGKREKGEVKRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S032</accession>
    <name>A1S032_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753077.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1415"/>
    <dbReference type="EnsemblBacteria" id="ABL78812">
        <property type="protein sequence ID" value="ABL78812"/>
        <property type="gene ID" value="Tpen_1415"/>
    </dbReference>
    <dbReference type="GeneID" id="4600732"/>
    <dbReference type="KEGG" id="tpe:Tpen_1415"/>
    <dbReference type="eggNOG" id="arCOG01200">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_1_2"/>
    <dbReference type="OMA" id="SSDYDIM"/>
    <dbReference type="OrthoDB" id="108083at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="119" mass="13541" checksum="8FA039F37040B6B1" modified="2007-02-06" version="1">MSDFVRLAWEGVRERRRFFESYVERIVGFFGGRVTLILFGSRARGDEMLSSDYDLAVVVEEEVDVLGLTETLVKMRPRGLPVDVVVLQKEELGDPLVTRMLTPCRMLYNGLGIQEAPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S033</accession>
    <name>A1S033_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753078.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1416"/>
    <dbReference type="EnsemblBacteria" id="ABL78813">
        <property type="protein sequence ID" value="ABL78813"/>
        <property type="gene ID" value="Tpen_1416"/>
    </dbReference>
    <dbReference type="GeneID" id="4600733"/>
    <dbReference type="KEGG" id="tpe:Tpen_1416"/>
    <dbReference type="HOGENOM" id="CLU_1297542_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="212" mass="24419" checksum="E2F51883D632482E" modified="2007-02-06" version="1">MEVERELARIYARAEFRAVSGPRRYVRIAVSNPYRRWTYTMMLFKVGCEKRARIHVLNEWWDKLHGWSSLEDEHVSVFGGLRRAIRGFFYSVARQCALEGDEGEETSITVEYHEALRRYIHAIFPLQTAERLIVVRGSLREVVSALAPVAVLVEELEPELAARFTHAGNVVTARPEELVDLRPSVCDSIVVFEKGKAYHVEPQSPVRRIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S036</accession>
    <name>A1S036_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753081.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1419"/>
    <dbReference type="EnsemblBacteria" id="ABL78816">
        <property type="protein sequence ID" value="ABL78816"/>
        <property type="gene ID" value="Tpen_1419"/>
    </dbReference>
    <dbReference type="GeneID" id="4600736"/>
    <dbReference type="KEGG" id="tpe:Tpen_1419"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="PVMFMDE"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="246" mass="26932" checksum="4D4F5F05E3698D53" modified="2007-02-06" version="1">MLEGLLVVKGLEKRYGGKAAVEGLSFAVRPGEIYALLGPNGAGKTTTLKCVVGLLRPDAGDVVVCGHSVLRERREVLRCTGYVPENPVGFDYLRVSEFLDFVGALRRIPRDVLSERAERYISMFGLEQYRDAFMGELSRGTVQKVLVVASLLHEPRVLVMDEPMSGMDPESQKTLKDELRRLAGRGAAVLLSSHMLDVVERFASRVGIISGGRLIAEGSLEDVKRAAELGEDATLEDVFMRLVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S076</accession>
    <name>A1S076_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753121.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1459"/>
    <dbReference type="EnsemblBacteria" id="ABL78856">
        <property type="protein sequence ID" value="ABL78856"/>
        <property type="gene ID" value="Tpen_1459"/>
    </dbReference>
    <dbReference type="GeneID" id="4600585"/>
    <dbReference type="KEGG" id="tpe:Tpen_1459"/>
    <dbReference type="eggNOG" id="arCOG01205">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159724_0_0_2"/>
    <dbReference type="OMA" id="REIKRIC"/>
    <dbReference type="OrthoDB" id="122104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="113" mass="13433" checksum="A32C2D6497011939" modified="2007-02-06" version="1">MLSKFFENWSRRREILAHARDYARLIKRICVEEVDRDCRVILFGSAARGDYRVDSDVDVLVVTEKAVDALSRAEVAAKIYERLGFRDPVELHVATPREFEEWYKRFIDVYEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1S078</accession>
    <name>A1S078_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753123.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1461"/>
    <dbReference type="EnsemblBacteria" id="ABL78858">
        <property type="protein sequence ID" value="ABL78858"/>
        <property type="gene ID" value="Tpen_1461"/>
    </dbReference>
    <dbReference type="GeneID" id="4600587"/>
    <dbReference type="KEGG" id="tpe:Tpen_1461"/>
    <dbReference type="eggNOG" id="arCOG04017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149114_0_0_2"/>
    <dbReference type="OMA" id="VEMVYIE"/>
    <dbReference type="OrthoDB" id="126746at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="140" mass="15400" checksum="EFC9209AB823328B" modified="2007-02-06" version="1">MGIRVRVRIVVGERSLETSALLNSGFESDEPDVCIPVALARRLGLWPPQEVRGEDAFTAGGEVTLYVLSAQARIQLLAGGEVKSEAACVLVVNPYVDEVLLSDYVMDELGVVALSFRRGLWRHASDPPSTVRESEKPEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S084</accession>
    <name>A1S084_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimethylamine:corrinoid methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753129.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1467"/>
    <dbReference type="EnsemblBacteria" id="ABL78864">
        <property type="protein sequence ID" value="ABL78864"/>
        <property type="gene ID" value="Tpen_1467"/>
    </dbReference>
    <dbReference type="GeneID" id="4601585"/>
    <dbReference type="KEGG" id="tpe:Tpen_1467"/>
    <dbReference type="eggNOG" id="arCOG03405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033581_1_0_2"/>
    <dbReference type="OMA" id="HYGTAGA"/>
    <dbReference type="OrthoDB" id="117682at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="475" mass="51563" checksum="98A3002AB7387244" modified="2007-02-06" version="1">MVPSVSVLSRREAEEITGEALRVLETVGVFFEDKGVERIALEGGGRLKDGRVLIPEDVVKEALRTAPRRIRLYDRDGREVAVLGEGARIFNPGSAAIRILDHGSQTPRNPTLEDLKKLVIVADYLKGLKAQSTALVPFEVPAEVKDAVRLYVVLKYSGKPVVTGAFTVENLPLMVEMLGAVREDYAEKPFAIFDVCPTPPLSWSTVTSRNLVDLARLGVPAEIISMPGLGATSPVTVYGAIIQHHAEVLSGIALSQLVKPGAPVIYGGSPTMIHPYYGTPSITAPEAVLISLAYRDLARYLDLPSHTYMGLSDSKTVDYQAGAETAYTAALAALAGFDVISGAGMLEYESVQSLEKLVLDNEACLIAERLARGVEVDPQALDALKEGVLEKKGNFLALRHTRQHYRSEILVPKVWDLAPRAKSTGVPLAELAHREVERILAEHKPPLLDGDALRRLDAVYSKLWESHGLKPVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S095</accession>
    <name>A1S095_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753140.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1478"/>
    <dbReference type="EnsemblBacteria" id="ABL78875">
        <property type="protein sequence ID" value="ABL78875"/>
        <property type="gene ID" value="Tpen_1478"/>
    </dbReference>
    <dbReference type="GeneID" id="4601579"/>
    <dbReference type="KEGG" id="tpe:Tpen_1478"/>
    <dbReference type="eggNOG" id="arCOG00825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_5_2_2"/>
    <dbReference type="OrthoDB" id="130137at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="9466" checksum="C9E289BC80678B63" modified="2007-02-06" version="1">MKTVVSRKGQVVIPKEVREKLGLVPGTVLRVRVEGKRVVLEPVEEPPREVFVEAGPEVTGRLLREAKLESDKALRLLRDLGVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S098</accession>
    <name>A1S098_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1481"/>
    <dbReference type="EnsemblBacteria" id="ABL78878">
        <property type="protein sequence ID" value="ABL78878"/>
        <property type="gene ID" value="Tpen_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1481"/>
    <dbReference type="eggNOG" id="arCOG04805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138948_0_0_2"/>
    <dbReference type="OMA" id="VSHAIAP"/>
    <dbReference type="OrthoDB" id="103779at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="141" mass="15230" checksum="14BBEDCD65673D9D" modified="2007-02-06" version="1">MQRYVRLAAASLALSATLMLVLGFAYPALVWALSLAVPKSGPELASCYGEKPQFFKPFAPENTSSGCDPFVPLDYALRQVPEVSRKTGLPEELVARVLRENAEKYRAANLYVLGPGYDIVNVVEVNKELAKLAERKGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0B2</accession>
    <name>A1S0B2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78892">
        <property type="protein sequence ID" value="ABL78892"/>
        <property type="gene ID" value="Tpen_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1495"/>
    <dbReference type="eggNOG" id="arCOG00812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_6_1_2"/>
    <dbReference type="OMA" id="GITKMDS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="11453" checksum="9D21BC9181885A5C" modified="2007-02-06" version="1">MGRVKIVGKMAKVVVVDAEGRVVIPKEVRERLGLAEGSRLLLVELSDDTIALRKLDARKILEAIAREVREKRVNLEKIEREVEEEADRVASRRIEEMLAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G1</accession>
    <name>A1S0G1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753206.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1545"/>
    <dbReference type="EnsemblBacteria" id="ABL78941">
        <property type="protein sequence ID" value="ABL78941"/>
        <property type="gene ID" value="Tpen_1545"/>
    </dbReference>
    <dbReference type="GeneID" id="4600838"/>
    <dbReference type="KEGG" id="tpe:Tpen_1545"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_0_2"/>
    <dbReference type="OMA" id="TVWWISA"/>
    <dbReference type="OrthoDB" id="71426at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="276" mass="31448" checksum="B0FA4CEA6C4FE425" modified="2007-02-06" version="1">MFRYGGITVIHRLDPRAKIVWLTSLMVIALIVIDPLYLLPPLAFAVAFLLLSRVYELKEFHSKWIMSTLLGSTLLLVLFNGLFAAVEVKKGTVLFYISFLGLKYPVTVEGFYLGVGAALRLLVIMLSFLTVAFTTYPRDLANSLEKVGLPYELTFTVALTFRFIPFLEEEARRIADALKSRGYRGFEEGGFLERLRAYSTLFTVLIVNSLSLVRRVGMVLEARCFGASPRRSSLREYRFRREDYLVVASSLLLLALYIVLRYCYGLGWLEYAHGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G6</accession>
    <name>A1S0G6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753211.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1550"/>
    <dbReference type="EnsemblBacteria" id="ABL78946">
        <property type="protein sequence ID" value="ABL78946"/>
        <property type="gene ID" value="Tpen_1550"/>
    </dbReference>
    <dbReference type="GeneID" id="4600843"/>
    <dbReference type="KEGG" id="tpe:Tpen_1550"/>
    <dbReference type="eggNOG" id="arCOG00153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052600_0_0_2"/>
    <dbReference type="OMA" id="WDHTARI"/>
    <dbReference type="OrthoDB" id="14670at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="428" mass="46360" checksum="DBBF7452346A1ED3" modified="2007-02-06" version="1">MPQKKVLVAAVVALVVLVALAAYVLYRPKPKSVTLTFVSTQLSPPTEQAFMRSLLSRFGNETGIKVDFVPLGYTDMVAKVEAEVNSGKVSTNIIGGLSSEVDYFASKGLVEDLSKFGSLPGRTFYPALEQASKMYGIKAMVPWMTATFVIVVNNKAFDYLPPGLTKDDVIKGTDKWTYDALLAWAKNIYEKTGKQAVGLPAGGGGLLHRFLHGYLYPSYTGYQAKAFNSPEAVELWKYLRELWKYTNPASTTYDAMADPLLKGDVWIAWDHVARVKAAITTSPDQFTVCPVPRGPKGRGYIVVLAGLAIPKGAPDQDSAWKLVEFLTRPEVQAKVAENVGFFPTVKEASPAITGPIKKLADGVSAQMAAPDSIAVMIPPLGAKAGSFNSVYRDAFTRIVLKGEDIQAVLADDAGKLDSIFKELKIPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I4</accession>
    <name>A1S0I4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753229.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1569"/>
    <dbReference type="EnsemblBacteria" id="ABL78964">
        <property type="protein sequence ID" value="ABL78964"/>
        <property type="gene ID" value="Tpen_1569"/>
    </dbReference>
    <dbReference type="GeneID" id="4601527"/>
    <dbReference type="KEGG" id="tpe:Tpen_1569"/>
    <dbReference type="eggNOG" id="arCOG07304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021628_0_0_2"/>
    <dbReference type="OrthoDB" id="130929at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="122" mass="13780" checksum="24C82A5C74E7FEB9" modified="2007-02-06" version="1">MTLVVKKVDERKLREFKAEAIRRGLTLSQAIEEAMDLWLSSRLLLTEADANNEAYAREKERLLKEHRGMYAVFAHARLVGVYATLDEVIAALKGIRPKHAVVVKVGEDKGGELEWWGGSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J4</accession>
    <name>A1S0J4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1579"/>
    <dbReference type="EnsemblBacteria" id="ABL78974">
        <property type="protein sequence ID" value="ABL78974"/>
        <property type="gene ID" value="Tpen_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1579"/>
    <dbReference type="eggNOG" id="arCOG00925">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="HHGQKIA"/>
    <dbReference type="OrthoDB" id="42569at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="261" mass="28629" checksum="EC7D8CF60C32EC90" modified="2007-02-06" version="1">MVLVANILEVKGVSKRFGGVVALQDVSLSVPSQGIVGLIGPNGSGKTTLFNVVTGFYVPDKGEVWFNDGNRSERIDGLNPNEVFAKGIVRTFQIPRLFKSLTVLENLLVTPFAQKGENPLKALKPSSWIEEERALARKAVSLLRRFGLLEYANVRVSELSGAHIKLLETIRGLMTPAKLFLLDEPAAGVEAGAAHELFRLVRELRSEGYTFLIVEHRIEILMQYVDYVYVLHNGQLLAEGKPEEVTSNPKVVEAYIGGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J9</accession>
    <name>A1S0J9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753244.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1584"/>
    <dbReference type="EnsemblBacteria" id="ABL78979">
        <property type="protein sequence ID" value="ABL78979"/>
        <property type="gene ID" value="Tpen_1584"/>
    </dbReference>
    <dbReference type="GeneID" id="4600548"/>
    <dbReference type="KEGG" id="tpe:Tpen_1584"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="FEVKMRR"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="356" mass="40582" checksum="BBBEB5657B8DECF6" modified="2007-02-06" version="1">MLFDPRPKERKEDLYDFERELGELEKFVGEPLVVVSGLRRTGKTSLILTALNELGEVYVYVDLREGASSAAGIYKLLSRSFGETYRRLGGGVGELFRRVLSRVRGVSFMGLEVSLDWSPRGRPLLSELFDALDELGERLGRKVVVVLDEFQRARTGFGLALQNAVAHSYDFNRNVSFVLSGSEMGVLYGVLGNPEGPLYGRAYVEVRTRKLSAEESLDFLRRGFEEAGLEVEGRELERAVNELDGIIGWLTYYGYLRLRGKGSLEEIVSEATALARRELEEFLSTRMSRRYRLVMRLLARGVKEWSELKRELERAEGREVSDRALYEVLQHLKKHSLIDENNEYTDPVNRRAALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q1</accession>
    <name>A1S0Q1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753296.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1636"/>
    <dbReference type="EnsemblBacteria" id="ABL79031">
        <property type="protein sequence ID" value="ABL79031"/>
        <property type="gene ID" value="Tpen_1636"/>
    </dbReference>
    <dbReference type="GeneID" id="4600915"/>
    <dbReference type="KEGG" id="tpe:Tpen_1636"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_2"/>
    <dbReference type="OMA" id="VPTYFRM"/>
    <dbReference type="OrthoDB" id="63271at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="293" mass="30945" checksum="41DDAF3DC266F96E" modified="2007-02-06" version="1">MRRPKTFGEWCILAGAVLTSLVALLAVLGEALAPGNATESYLVVDGKVYEVPPLLPPLSEVRLGSRTVVFLMGTDQLGRDVFSRLLAGARFVLAVAFLSTAVSALVGVLLGLLSGYVGGLLDRALSLVMDSLYSLPGLIVAIALAALLGTGVVNMSMAIAVAYIPSYFRMVRGQVLSLKSAPFVEAARVAGAGPLDVALRQIMPNTFPAIASLLPITFADAIITEAGLSFLGLGIEPPTPDWGFDLNKGRQFFLAGYWWIGVFPGLAIVVTVLGFLLLGEGLNEMLNPKRWQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R2</accession>
    <name>NNR_THEPD</name>
    <protein>
        <recommendedName>
            <fullName>Bifunctional NAD(P)H-hydrate repair enzyme Nnr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName>ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber>4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>NAD(P)H-hydrate epimerase</fullName>
                <ecNumber>5.1.99.6</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>NAD(P)HX epimerase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">nnr</name>
        <name type="ordered locus">Tpen_1647</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136"/>
    <dbReference type="EC" id="5.1.99.6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753307.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1S0R2"/>
    <dbReference type="SMR" id="A1S0R2"/>
    <dbReference type="STRING" id="368408.Tpen_1647"/>
    <dbReference type="EnsemblBacteria" id="ABL79042">
        <property type="protein sequence ID" value="ABL79042"/>
        <property type="gene ID" value="Tpen_1647"/>
    </dbReference>
    <dbReference type="GeneID" id="4601241"/>
    <dbReference type="KEGG" id="tpe:Tpen_1647"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_2"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="41305at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000416432" description="Bifunctional NAD(P)H-hydrate repair enzyme Nnr">
        <location>
            <begin position="1"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal">
        <location>
            <begin position="224"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="NAD(P)H-hydrate epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX 1; for epimerase activity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX 1; for epimerase activity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP-dependent (S)-NAD(P)H-hydrate dehydratase" evidence="1">
        <location>
            <begin position="224"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX 2; for dehydratase activity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>1</label>
            <note>for epimerase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>1</label>
            <note>for epimerase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>2</label>
            <note>for dehydratase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>2</label>
            <note>for dehydratase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="524" mass="55261" checksum="A996719B2E810778" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T2</accession>
    <name>A1S0T2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIR synthase related protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753327.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1667"/>
    <dbReference type="EnsemblBacteria" id="ABL79062">
        <property type="protein sequence ID" value="ABL79062"/>
        <property type="gene ID" value="Tpen_1667"/>
    </dbReference>
    <dbReference type="GeneID" id="4601249"/>
    <dbReference type="KEGG" id="tpe:Tpen_1667"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="NDIAVRG"/>
    <dbReference type="OrthoDB" id="34102at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="153"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="335" mass="35476" checksum="673ECA866D98663D" modified="2007-02-06" version="1">MPFRRLGKLTYGELEELLSRLRRQDASVLLGPAIGEDAALIDLGDKVLVVHADPITGAVSNIGWLSVHVSANDVATRGVQPRWLVTVVLLPEGAGQDVLWDIAGQLRKAADEIGATIVGGHTEFTPGLDRPILVTTAMGVGGKGEVLATSRARPGDALILTKGAGIEGTAILATELYDELSRKVDREVLERAKSFIYEVSVVKDALTAVRAGGVHAMHDPTEGGVLGGLQEMAIAANAGLVVEEEKIPVREETKAVCRALGVDPLRLISSGSLLIAVEGSRARDVVDALSREGIPAAVIGRLTEGSERILVKRGGEIVDLNEPVVDELWRILGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U0</accession>
    <name>A1S0U0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1675"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79070">
        <property type="protein sequence ID" value="ABL79070"/>
        <property type="gene ID" value="Tpen_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1675"/>
    <dbReference type="eggNOG" id="arCOG05412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_2"/>
    <dbReference type="OMA" id="WHVCEHG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="513" mass="58756" checksum="704E6A9E428911A6" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V3</accession>
    <name>A1S0V3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753348.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1688"/>
    <dbReference type="EnsemblBacteria" id="ABL79083">
        <property type="protein sequence ID" value="ABL79083"/>
        <property type="gene ID" value="Tpen_1688"/>
    </dbReference>
    <dbReference type="GeneID" id="4600576"/>
    <dbReference type="KEGG" id="tpe:Tpen_1688"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_1_1_2"/>
    <dbReference type="OMA" id="VHYELLG"/>
    <dbReference type="OrthoDB" id="120852at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="138" mass="15371" checksum="C53893C0587A8E63" modified="2007-02-06" version="1">MSGEYVETLKRRAVKLLQVARSIEDAGLALFLAEQSAQLYIKAVHYELLGEKVRGHGLRELLGLFARSLREAGYEKEADAITGLALEHRRALALLEEAYTMGRYGTYVYGSEDVEIAVRTVEKLVETLEKVAKSVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X7</accession>
    <name>A1S0X7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1712"/>
    <dbReference type="EnsemblBacteria" id="ABL79107">
        <property type="protein sequence ID" value="ABL79107"/>
        <property type="gene ID" value="Tpen_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1712"/>
    <dbReference type="eggNOG" id="arCOG04188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_2"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="190" mass="21864" checksum="9FB1133DC166921E" modified="2007-02-06" version="1">MGVCLVPFKSFRRLEIPDVVLVEYAVFPDERGFFAELYKRTEFLSGGVPYGFVQVNLSFSRAGVVRALHYQLKPMEQGKLVYVVSGRVFDVAVDIRRGSPWFGRHVSVVLEPGFALWVPPGFAHGFQALEDSFFLYFVTKEYSPQHERCIFWRDPDLGIRWPRVEGAVVSGRDSRCPLFREAETNFEYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z1</accession>
    <name>A1S0Z1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753386.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1726"/>
    <dbReference type="EnsemblBacteria" id="ABL79121">
        <property type="protein sequence ID" value="ABL79121"/>
        <property type="gene ID" value="Tpen_1726"/>
    </dbReference>
    <dbReference type="GeneID" id="4601751"/>
    <dbReference type="KEGG" id="tpe:Tpen_1726"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060155_0_0_2"/>
    <dbReference type="OrthoDB" id="78828at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="262" mass="28677" checksum="21286903ED09DA60" modified="2007-02-06" version="1">MNAIEQVAREASETQVVVMAGGEGRRMGLVPVPKPLLELNGKPLLEHCIEYYARCGFKDFTVLTRQEPVAEKAREAGKKLGVNVKVSMDPPLPKVGKGKALKHALQTGAVDPERRALVVFPDDLYLDDTLPLRFLASHVEAARRMGAWASVAVTLGLALPYGVVEIDAEGMAVSFKEKPVLPIHASIGLYAFEPQALKLLLEVVDMDSPSAVEFESTLLPLLAEQRRLHAYPVPHHAWLPLNTLKELDEASKILGGNREALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S124</accession>
    <name>A1S124_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753419.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1759"/>
    <dbReference type="EnsemblBacteria" id="ABL79154">
        <property type="protein sequence ID" value="ABL79154"/>
        <property type="gene ID" value="Tpen_1759"/>
    </dbReference>
    <dbReference type="GeneID" id="4601957"/>
    <dbReference type="KEGG" id="tpe:Tpen_1759"/>
    <dbReference type="eggNOG" id="arCOG07489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128034_0_0_2"/>
    <dbReference type="OMA" id="LIHTDEV"/>
    <dbReference type="OrthoDB" id="123839at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="180" mass="20038" checksum="08C5A42743ADA8B4" modified="2007-02-06" version="1">MPEDEKTVEVSPVWEEALVQEFVYLIGHLNHSEQHLLEADAYLGRPAFGDLVDRLRECRKIVGQALFEIEALEARGGGGDFRTSWESVWCTLKHLATALIHTDEVIEKVLKKARSGQQDLEAAARINSQLQSLLEARKSILDSIEDLVARAKALSGSVDLSSVRCREDLCLEENDSHEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S160</accession>
    <name>A1S160_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1795"/>
    <dbReference type="EnsemblBacteria" id="ABL79190">
        <property type="protein sequence ID" value="ABL79190"/>
        <property type="gene ID" value="Tpen_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1795"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="111519at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="234" mass="25901" checksum="C9583E5F96FD042D" modified="2007-02-06" version="1">MPGVIRAVDLVKYLGGIQVVRGVSLDVERSRITVIMGPNGSGKTTLLRMLGLLLPPDGGLLEMDGVNLLSLDEEGRRGFLRRVAFVPQKPVVLTANVYRNIAIPLRLRGLDPRTADAEAWRWLKEVNLEKHAWKSAHSLSGGERQLLALARALALSPDVLLLDEPTSHLDPKNAAFIQRLVKEYVSERGIHCVVVSHNVREAKFLADEILVMVSGRIKARYGPDAPESELLKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S162</accession>
    <name>A1S162_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753457.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1797"/>
    <dbReference type="EnsemblBacteria" id="ABL79192">
        <property type="protein sequence ID" value="ABL79192"/>
        <property type="gene ID" value="Tpen_1797"/>
    </dbReference>
    <dbReference type="GeneID" id="4601920"/>
    <dbReference type="KEGG" id="tpe:Tpen_1797"/>
    <dbReference type="eggNOG" id="arCOG07487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104115_0_0_2"/>
    <dbReference type="OMA" id="YGELQFR"/>
    <dbReference type="OrthoDB" id="137904at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="173" mass="17930" checksum="4EC9726ECE30DC87" modified="2007-02-06" version="1">MNAKSLSVAAVLGALYAALVIVLQPISFLAFQVRLADALLPLSMVLGVPAAVGVSVGCFFGNLVAAPWGSLALGLFDAVFGSLANFAASYLAYIVAYNKGRRAKLAGAVLEAVVVSGIVGFYLKYLLLWAMGVDMPLEAVFLGVLAGSVVSIIAIGYPLAILVEKPLKNLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1S176</accession>
    <name>A1S176_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1811"/>
    <dbReference type="EnsemblBacteria" id="ABL79206">
        <property type="protein sequence ID" value="ABL79206"/>
        <property type="gene ID" value="Tpen_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1811"/>
    <dbReference type="HOGENOM" id="CLU_1313185_0_0_2"/>
    <dbReference type="OrthoDB" id="136076at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="21697" checksum="63A04DA5C7ECFBC2" modified="2007-02-06" version="1">MQASGDDVAGLVESIVGRSLSEIAVEALVKAALAGLPITPVKTGSRTVSVLYEGRRAYFRVTAARNLSGGYIVCLRVYTVDCGRVAYVSEKGEVSLDIGAIPGYLSSPGELYNGFVADVWTARLRSVLGNLLEEIPRERVPAGIREGVARLLGDSFPLVKPYVSRLTGDYAFGRSSVYPVWVDPEGLAFSVSRIALEKIVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S187</accession>
    <name>A1S187_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753482.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1822"/>
    <dbReference type="EnsemblBacteria" id="ABL79217">
        <property type="protein sequence ID" value="ABL79217"/>
        <property type="gene ID" value="Tpen_1822"/>
    </dbReference>
    <dbReference type="GeneID" id="4602059"/>
    <dbReference type="KEGG" id="tpe:Tpen_1822"/>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_4_2"/>
    <dbReference type="OMA" id="SAKWKLE"/>
    <dbReference type="OrthoDB" id="86909at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="256" mass="27978" checksum="59735234E144ADB6" modified="2007-02-06" version="1">MKDLSPEELERYDRQIRVWGVEAQKKLKSSTVLVVGAGGLGSPVAFYLVAAGVGKLIIVDAEDVELSNLNRQILHWTSDLGKAKVESAKEKLEKLNPHVEVVTLKQKIRSLEDALKLVEDADVVVDCLDNWSTRFLLNEACVKLGKPLVHGAVRGLYGQLTVVKPFEGPCLRCILPREPPEERPFPVAGPTPGVIGSLEALEVIKILTGYGEPMVGRLLFYDGVRNTFDVVKVERRPDCPVCGVSVRKVASGGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW41</accession>
    <name>A1RW41_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751686.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0011"/>
    <dbReference type="EnsemblBacteria" id="ABL77421">
        <property type="protein sequence ID" value="ABL77421"/>
        <property type="gene ID" value="Tpen_0011"/>
    </dbReference>
    <dbReference type="GeneID" id="4601462"/>
    <dbReference type="KEGG" id="tpe:Tpen_0011"/>
    <dbReference type="eggNOG" id="arCOG04032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091232_0_0_2"/>
    <dbReference type="OMA" id="AKHYGPR"/>
    <dbReference type="OrthoDB" id="99763at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="166" mass="19146" checksum="5E9FEFEA37BBDD54" modified="2007-02-06" version="1">MVGERLGRFQVMALLQAARYYVLTGDLEKAYSFGLNRAIFYAWAKRRGVPVAASREKIARGVEVEKDSSGRTLVYVGDEAAYLSEHGWFTMGGQDQTPELFEREVKSRVEKVMPFEEAWRIAVEYVKSFDKRTLLSQADFYEKVYLPVRDSFPEIPPRKGRQTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW55</accession>
    <name>A1RW55_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751700.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0025"/>
    <dbReference type="EnsemblBacteria" id="ABL77435">
        <property type="protein sequence ID" value="ABL77435"/>
        <property type="gene ID" value="Tpen_0025"/>
    </dbReference>
    <dbReference type="GeneID" id="4601062"/>
    <dbReference type="KEGG" id="tpe:Tpen_0025"/>
    <dbReference type="HOGENOM" id="CLU_2505133_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="85" mass="9370" checksum="C8B48A34F7920249" modified="2007-02-06" version="1">MLEKLLLGWLLAVFFSFIILAVLVTLAAAERVTGVTPWSSLSVFRAYAETAVLPLVLAFLAVVVIYVLTRYAGKALDFLVQRINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW78</accession>
    <name>A1RW78_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0048"/>
    <dbReference type="EnsemblBacteria" id="ABL77458">
        <property type="protein sequence ID" value="ABL77458"/>
        <property type="gene ID" value="Tpen_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0048"/>
    <dbReference type="eggNOG" id="arCOG14987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115599_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="110" mass="11789" checksum="1BFEEE63277CDA79" modified="2007-02-06" version="1">MSSREGVLRSFLSRARGFRGVAAVEGGKVYLAGEITREQVERAAEAFSFASEVLRKARGIGVKVLVAEGEGGGLVYAKYGFTSYVVAVYRDISLGVAYHEVKRLVAELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA2</accession>
    <name>A1RWA2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751747.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0072"/>
    <dbReference type="EnsemblBacteria" id="ABL77482">
        <property type="protein sequence ID" value="ABL77482"/>
        <property type="gene ID" value="Tpen_0072"/>
    </dbReference>
    <dbReference type="GeneID" id="4601571"/>
    <dbReference type="KEGG" id="tpe:Tpen_0072"/>
    <dbReference type="HOGENOM" id="CLU_2191164_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="108" mass="11786" checksum="3C1A7C57828CD6BC" modified="2007-02-06" version="1">MERVAEAAAFLSAAEEKFSKDEDFERDARLAILLALRAVSEDLGSLDPIELAGTLPERIIGEVILLKEISTRAYSVRGEALLEASREAVEIAVSIILYRVASNQGEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWC5</accession>
    <name>A1RWC5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751770.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0095"/>
    <dbReference type="EnsemblBacteria" id="ABL77505">
        <property type="protein sequence ID" value="ABL77505"/>
        <property type="gene ID" value="Tpen_0095"/>
    </dbReference>
    <dbReference type="GeneID" id="4601851"/>
    <dbReference type="KEGG" id="tpe:Tpen_0095"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2646125_0_0_2"/>
    <dbReference type="OrthoDB" id="132167at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8222" checksum="9E3115A1A54E177B" modified="2007-02-06" version="1">MSVRIIFYGFLIDVAKARELTVGVEKPTRLEEILGEGFLAKSGKDLVVLVNDLPATLDTYVRPGDVVKILPHIGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE7</accession>
    <name>A1RWE7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751792.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0117"/>
    <dbReference type="EnsemblBacteria" id="ABL77527">
        <property type="protein sequence ID" value="ABL77527"/>
        <property type="gene ID" value="Tpen_0117"/>
    </dbReference>
    <dbReference type="GeneID" id="4601174"/>
    <dbReference type="KEGG" id="tpe:Tpen_0117"/>
    <dbReference type="eggNOG" id="arCOG01727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951940_0_0_2"/>
    <dbReference type="OrthoDB" id="55053at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="302" mass="32946" checksum="AE9D9BF7792F52AB" modified="2007-02-06" version="1">MASLASIEDRIAYLGGLLTRYSGDRVKELFPEIVEEASYALFGGKMLRGTLSLLVASMFTAQVEKVLPIALAVELMHAASLVHDDIADASPTRRGRPSFWSKYGLEDAITVPHVLMPVAISLVADAGVEAVKESMNAWRRSALGQLWDTRILRGREVPVGYEKLIEYKTAAVFEASCTLPLIAIGRRDIVESGRVYGRFFGLLYQVLDDFSDAERGVVDSGSTRLLLREASRSSGSLAEYVEGLAGRYFGMLVEVSGQLESSLVDFAYASMNAFAREAGEHVARVVRAITSGKHGVGKFQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG1</accession>
    <name>A1RWG1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751806.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0131"/>
    <dbReference type="EnsemblBacteria" id="ABL77541">
        <property type="protein sequence ID" value="ABL77541"/>
        <property type="gene ID" value="Tpen_0131"/>
    </dbReference>
    <dbReference type="GeneID" id="4600716"/>
    <dbReference type="KEGG" id="tpe:Tpen_0131"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_2"/>
    <dbReference type="OMA" id="YLRMHGR"/>
    <dbReference type="OrthoDB" id="61105at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="28030" checksum="D16603373438488B" modified="2007-02-06" version="1">MELYVGSSGWVYDWNPDGLAWYASQSGFNAVELNMSFYSFPKRTTVEKWAEESEGLRWSIKVHRSITHVRRLNEKSHATWSKFRELFEPIEDRIDFYLFQLPPSMAFTPEAASRVAAYASLAEKIAVEPRHKSWFRKEVYEFFEEKGVFFVTPDSPLFEGLPPDGVVCIRGVVYVRMHGRLAWYNYGYLDEELREVAEKIISANPQRAYVFFNNDHDMLGDGLRLKEILLERGVSFPKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWJ1</accession>
    <name>A1RWJ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751836.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0161"/>
    <dbReference type="EnsemblBacteria" id="ABL77571">
        <property type="protein sequence ID" value="ABL77571"/>
        <property type="gene ID" value="Tpen_0161"/>
    </dbReference>
    <dbReference type="GeneID" id="4601270"/>
    <dbReference type="KEGG" id="tpe:Tpen_0161"/>
    <dbReference type="eggNOG" id="arCOG02849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_3_0_2"/>
    <dbReference type="OMA" id="SFWGKGG"/>
    <dbReference type="OrthoDB" id="76334at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="300" mass="34252" checksum="262B6CEBDEAA7DC9" modified="2007-02-06" version="1">MMRVPKKLVSFWGKGGVGKTTLSSAVAVSLSKMGYRTYLLSSDFVPSLQDVLGVELSREPLELSENLVVDQLFEEKVIEMWKERFGEEVYRVASSIFPVGREIIDYVAGAPGIVEEFTLYYIYELYRNEDFDVLVWDTMATGGGLRMLRIEKEFYDHLGEAVKLYLRVKGVIDRIRTGSEDPLKLIESWRELAQKVLDFLRGSHHVASLVSRSLPVDYYVATRVYRELLEFGIPVKMLFVNMVSGSAEENLYFKKFYDSFGEKLTLLRVPRVDPSPRGIDSLSKLLEKNDVDTILSLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL3</accession>
    <name>A1RWL3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase (Ubiquinone), 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751858.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0183"/>
    <dbReference type="EnsemblBacteria" id="ABL77593">
        <property type="protein sequence ID" value="ABL77593"/>
        <property type="gene ID" value="Tpen_0183"/>
    </dbReference>
    <dbReference type="GeneID" id="4600885"/>
    <dbReference type="KEGG" id="tpe:Tpen_0183"/>
    <dbReference type="eggNOG" id="arCOG01547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_2"/>
    <dbReference type="OMA" id="CDPCFTC"/>
    <dbReference type="OrthoDB" id="4328at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="299"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="471"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="567" mass="64256" checksum="2C7DE322799D1D9C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM5</accession>
    <name>A1RWM5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13935"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0195"/>
    <dbReference type="EnsemblBacteria" id="ABL77605">
        <property type="protein sequence ID" value="ABL77605"/>
        <property type="gene ID" value="Tpen_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0195"/>
    <dbReference type="eggNOG" id="arCOG04127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051301_1_1_2"/>
    <dbReference type="OMA" id="RKIHREM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="6">
        <location>
            <begin position="96"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="421" mass="46156" checksum="723202B71036557B" modified="2007-02-06" version="1">MPRVSIPADYTLIVEGDAAFRVLNGEVVTFGATLESGKEYKVDPFRAIPLYALRDSEVEVESGKFSYVKGNTVPQSWEAAAERIGSLGARRVMVVGGVDSGKTSFVTFLANRLSQAGERVGIVDADLGQKSIGPPATIGLGVVASPLVSLGEAEFVDGFFVGSVTPSGLLHRHVVGVRLMVEVAETRMGVRRVVVDTTGWVSEQGGRELKLFKAMALEPDVVVVVSRGDECLHIVNTLGRLFEVVQVEAPKAVRLRGRIDRREYRKVMYRKFFEGAKEYEYDFSKGVLYSTVFTGSELPEDERRRVEELLGVRVVYAEKSGDHVAFFTERSVDEQAASLLKAIYGSRQVKLLTGFEFLHTLVGIRNREKYLKGVGIVTGVYPQRKALRVLSTAAPSGDETLMLGLVKVNPVSFEEEAILEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU7</accession>
    <name>RFCS_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Replication factor C small subunit</fullName>
            <shortName evidence="1">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rfcS</name>
        <name type="ordered locus">Tpen_0267</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751942.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWU7"/>
    <dbReference type="SMR" id="A1RWU7"/>
    <dbReference type="STRING" id="368408.Tpen_0267"/>
    <dbReference type="EnsemblBacteria" id="ABL77677">
        <property type="protein sequence ID" value="ABL77677"/>
        <property type="gene ID" value="Tpen_0267"/>
    </dbReference>
    <dbReference type="GeneID" id="4601685"/>
    <dbReference type="KEGG" id="tpe:Tpen_0267"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_2"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="37207at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000292191" description="Replication factor C small subunit">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <sequence length="325" mass="36665" checksum="9BD00C15394FF8A9" modified="2007-02-06" version="1">MSEELWVEKYRPRSLDEIVDQEEIVKRLKEFVKNKNMPHLLFAGPPGTGKTTAALALAHDLYGESWRDNTLELNASDERGIDVIRSRIKDYARTLPIGDVPFKLVILDEADNMTGDAQQALRRTMELFSRNTRFILIANYASKIIEPIQSRCAVFRFQPLPKGDAFQRLRWIAQQEGITVDDGALEAIWEESQGDLRKAINTLQAASAISRNVTEEVVYAALGRVKPKEVREMIESALKGNLLEARDKLRLLLYNYGLSGVDIIRFIHREVLSQKSVRLDDATLAELLVLVGETNYRIVEGSDDEIQLMALLSKLALVSKKAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV7</accession>
    <name>A1RWV7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps9</name>
        <name evidence="9" type="ordered locus">Tpen_0277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751952.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0277"/>
    <dbReference type="EnsemblBacteria" id="ABL77687">
        <property type="protein sequence ID" value="ABL77687"/>
        <property type="gene ID" value="Tpen_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="4601899"/>
    <dbReference type="KEGG" id="tpe:Tpen_0277"/>
    <dbReference type="eggNOG" id="arCOG04243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="OMA" id="FMGQAEA"/>
    <dbReference type="OrthoDB" id="115425at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_A">
        <property type="entry name" value="Ribosomal_S9_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="14841" checksum="D285F07FF1F9FE5B" modified="2007-02-06" version="1">MKMVLASARRKTARARVILRDGRGRVFVNGTPLEILEPEVIRLKIMEPLRLAGSLAEKVDIYAEAEGGGIVSQASAIRTAIARALVEWSGSEELKKLYLAYDRRLLVEDPRQAEPKKPRGRSARAKRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWZ6</accession>
    <name>A1RWZ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0317"/>
    <dbReference type="EnsemblBacteria" id="ABL77726">
        <property type="protein sequence ID" value="ABL77726"/>
        <property type="gene ID" value="Tpen_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0317"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="137"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="276" mass="29673" checksum="B5CC999F127B0D56" modified="2007-02-06" version="1">MGDELVFVEKKVFPDGEIYVRVPSKPSGVAIVVSSTHPPQERRLLELLLTVEALSSYAQGSVIAVVPYLAYARQDKRFLEGEPISIKVVLKALEAAGASGLLAVDVHQPRVLSEWLSIPSKNVLPFEDIAGYLYGKVKNAVVLAPDMGALERARRVAELIGADFDYLVKERDRVTGEVRVQPKSLEVNGRDVVIVDDIISTGKTIALAAKSALAQGASSVTAVCTHAVMVQGALDLLYYSGVREVVATDTVPSPVSKISVAPSVVRGLRELLEDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX02</accession>
    <name>A1RX02_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77732">
        <property type="protein sequence ID" value="ABL77732"/>
        <property type="gene ID" value="Tpen_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0323"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8313" checksum="1BB61F3DD8DC700B" modified="2007-02-06" version="1">MSDPRDIVRTIGALSRLLASTLKGDELYEARLVEALDAIEEFLASVGSAPARVEEDEELARELEEDVEELRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX36</accession>
    <name>A1RX36_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752031.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0357"/>
    <dbReference type="EnsemblBacteria" id="ABL77766">
        <property type="protein sequence ID" value="ABL77766"/>
        <property type="gene ID" value="Tpen_0357"/>
    </dbReference>
    <dbReference type="GeneID" id="4600895"/>
    <dbReference type="KEGG" id="tpe:Tpen_0357"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_1_2"/>
    <dbReference type="OMA" id="EKYRWIP"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="27530" checksum="D95A24C4C2571C15" modified="2007-02-06" version="1">MTRELKYGKVRVVLSEDVHPETFLAGFHGVGHVGWIAVKHVVEKLEAQRVGYLFTQYMPPFVNVRSGIRTPYELYFSQGMLIFLPNVPVSPKDFISVPEALAELSITLGVKLSVLFGGLDASYKEPDAKPRIAPTRAFLLSKEDLIKEKGYPVLEEHLGIVGPLAILLSVFEANNVPAVAILPYAAADRPDPRAAAEAIKVFQEITGVRISVEELLEQGERLEKEVAEVEKKIKEAMREREPPMYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX63</accession>
    <name>A1RX63_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose 1,5-bisphosphate isomerase</fullName>
            <shortName evidence="3">R15P isomerase</shortName>
            <shortName evidence="3">R15Pi</shortName>
            <ecNumber evidence="3">5.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribulose 1,5-bisphosphate synthase</fullName>
            <shortName evidence="3">RuBP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate</text>
            <dbReference type="Rhea" id="RHEA:32243"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="5.3.1.29"/>
        </reaction>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Reaction proceeds via a cis-phosphoenolate intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.29" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752058.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0384"/>
    <dbReference type="EnsemblBacteria" id="ABL77793">
        <property type="protein sequence ID" value="ABL77793"/>
        <property type="gene ID" value="Tpen_0384"/>
    </dbReference>
    <dbReference type="GeneID" id="4602152"/>
    <dbReference type="KEGG" id="tpe:Tpen_0384"/>
    <dbReference type="eggNOG" id="arCOG01124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_1_2"/>
    <dbReference type="OMA" id="ISYKRGS"/>
    <dbReference type="OrthoDB" id="36100at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043917">
        <property type="term" value="F:ribose 1,5-bisphosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02230">
        <property type="entry name" value="R15P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005250">
        <property type="entry name" value="Ribulose_e2b2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00511">
        <property type="entry name" value="ribulose_e2b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="331" mass="36265" checksum="A5F0906B445FC95D" modified="2007-02-06" version="1">MSQGVVRAFPPEVLEIARKIRDMEIRGAGRIAKAAAEALRIAALKYEGESCEEFKEYMLKVAELLVSTRPTAVSLPNAVNYVVSQLKKPGIDSLEKARSLVVSRASRFIEYADQALSKISEFGEKVIRDGDTILTHCNSAAATGILVLAHKKGKDITVYATETRPKFQGYITAESLLREGVRVRIIPESAVRSIMKRIDKVVVGADTVAANGAVVNKVGTSLIALAARERGIDFFVATETFKFSPFTLIGDIVPIEFRAETEIVDEEMLARHPKLRVLNPAFDVTPPDFITGIITEIGIIPPQAASIVIEEMYGHPVMHESLKAVEEDFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX85</accession>
    <name>A1RX85_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752080.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0406"/>
    <dbReference type="EnsemblBacteria" id="ABL77815">
        <property type="protein sequence ID" value="ABL77815"/>
        <property type="gene ID" value="Tpen_0406"/>
    </dbReference>
    <dbReference type="GeneID" id="58786991"/>
    <dbReference type="KEGG" id="tpe:Tpen_0406"/>
    <dbReference type="eggNOG" id="arCOG02204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2447825_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="89" mass="9820" checksum="C8D6598352445E73" modified="2007-02-06" version="1">MGGETLSTIARLLRMVDKPTIEEYKLMLRVVLLGLGLLGTVGFFFQLLGSFLEFARIGALPKEYTLFGGIIVIAATLALALYLRSREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX87</accession>
    <name>A1RX87_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="9" type="ordered locus">Tpen_0408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752082.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0408"/>
    <dbReference type="EnsemblBacteria" id="ABL77817">
        <property type="protein sequence ID" value="ABL77817"/>
        <property type="gene ID" value="Tpen_0408"/>
    </dbReference>
    <dbReference type="GeneID" id="4601502"/>
    <dbReference type="KEGG" id="tpe:Tpen_0408"/>
    <dbReference type="eggNOG" id="arCOG00403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_2"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="16385at2157"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="199"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="52160" checksum="C90FAC61D7B27D9F" modified="2007-02-06" version="1">MWSMLYLLRNNPEKLIENMKARFMDPSLVENAIKLDVEWRAKKKEYDELKHRLNEVSAKVRSSTGQEREKLILEARELSSKVSLLEKELAELEAKRELALRRLPNVIHESVPIGPDETFNKPVRYWGRPKVFREHLEGFLKETKEKGFVVDYEVLDWKPLGHAEFLESKGLTNTLKAAEVAGARFYYMFNDLVWLAIALELYALEYLAGKGFTILLPPLMLRREILEGVVSFDDFKDMIYKIDGEDLYLIGTAEHPIAALHAGEVLAEKELPLLYAGVSESFRKEAGAHGKDTKGIFRVHHFEKVEQFVFSHPDESWEWHEKLIRNAEELWQGLEIPYRIVNIASGDLGVVAAKKYDLEAWMPAQGKYREMVSCSNCTDWQSYRLNIRYAEVRGGPSKGYVHTLNSTALAIQRTITAIVENHQTPDGYVKVPKALHKYLEPFENHFRVLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA5</accession>
    <name>A1RXA5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="15" type="ordered locus">Tpen_0426</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752100.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0426"/>
    <dbReference type="EnsemblBacteria" id="ABL77835">
        <property type="protein sequence ID" value="ABL77835"/>
        <property type="gene ID" value="Tpen_0426"/>
    </dbReference>
    <dbReference type="GeneID" id="4602105"/>
    <dbReference type="KEGG" id="tpe:Tpen_0426"/>
    <dbReference type="eggNOG" id="arCOG04050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="OrthoDB" id="41214at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="12">
        <location>
            <begin position="21"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="13">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABL77835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="341" mass="38681" checksum="BCC4F13C94FD1976" modified="2007-02-06" version="1">MGVNLTPLVKPKKIGLQGVRGRVLAVDALNSVYQFLALVRDERGMLFTNSRGEVTSHLIGLLSRYSRLAYEYDASFIFVFDGSPHPLKARELEKRKKQREKAKQEYAELLSKGDLRKAFSKAVVSAEVDDRIVESTKRLVRLMGFPVVDAVHDAEAQAAYLVKRGEAWAVSSMDWDSLLYGSPRLVRYLTLTGFEWLPSKQKARKLIPELVTLEELLSGHGITLRQLVDIAILVGTDYNEGVKGVGPLRALKMIKRYGSLENLPVSVRRHLPENYEAVRQIFLNPPLNEKYSLSFSPPDKEGLMKFLVDENDFSPKRVEVYLRRLEAAYERRKGGLTRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH3</accession>
    <name>A1RXH3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752168.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0496"/>
    <dbReference type="EnsemblBacteria" id="ABL77903">
        <property type="protein sequence ID" value="ABL77903"/>
        <property type="gene ID" value="Tpen_0496"/>
    </dbReference>
    <dbReference type="GeneID" id="4601330"/>
    <dbReference type="KEGG" id="tpe:Tpen_0496"/>
    <dbReference type="eggNOG" id="arCOG00552">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478989_0_0_2"/>
    <dbReference type="OMA" id="NDIAREX"/>
    <dbReference type="OrthoDB" id="126658at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="2">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="182" mass="21233" checksum="D89D2BD560190CE3" modified="2007-02-06" version="1">MIEVLARTLLYYDVEIAVKALKDKTVRLPGGLEVRLRQGTKAKLPLFLAEELVESEVAEYVEEDLVKKAELKKQLWAEGKNEKLERLDDSFYLKFRLYVRALERRKNAGDRNAEKELEELKTLFTDLVRSRMRKIAILAVLSPEVSRDHIANMTREEQILYVSLCNLLNEWTASMRKFVMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH9</accession>
    <name>A1RXH9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="12" type="ordered locus">Tpen_0502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752174.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0502"/>
    <dbReference type="EnsemblBacteria" id="ABL77909">
        <property type="protein sequence ID" value="ABL77909"/>
        <property type="gene ID" value="Tpen_0502"/>
    </dbReference>
    <dbReference type="GeneID" id="4601336"/>
    <dbReference type="KEGG" id="tpe:Tpen_0502"/>
    <dbReference type="eggNOG" id="arCOG01228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="25871at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="98"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="99"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL77909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="431" mass="48049" checksum="F1E0EB0DDED83465" modified="2007-02-06" version="1">MESLKESLMGVVSRIRSSVLLDSREVDLVIRELQRALLKADVDVGLVLSVSERIKKRFFEEEQPPGFSKKEVLVKILYEELVNLLGGEETPELKVSSTPFKVMFVGLEGSGKTTTVAKVANYYKRKGYRVGVVAADTYRPGAYEQLRSLAEKVGVPFYGDPQERDAVSLALRGVKVLSDKGIQMILIDTAGRHKDEEALMEEVKTLYREVKPDAVVLVVDATQGSAVARQARAFQEAMPFGYVIVAKMDGSAKGGGALSAVASSKARVIFIGTGEKIEDLEEFNPKKFVARLLGMPDLEALLQRFSEFARLEKERARAIASGKITLLDLKEQLEGLRKMGPLSKIAEMMGLQVKVSEEDLNIDKWINIMNSMTMEELLNPEIIDSSRMRRIARGSGVSPRDVKQLLEAYRNMKKVMRQLSRSRMRGLPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK7</accession>
    <name>A1RXK7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752202.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0531"/>
    <dbReference type="EnsemblBacteria" id="ABL77937">
        <property type="protein sequence ID" value="ABL77937"/>
        <property type="gene ID" value="Tpen_0531"/>
    </dbReference>
    <dbReference type="GeneID" id="4601349"/>
    <dbReference type="KEGG" id="tpe:Tpen_0531"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="OrthoDB" id="144493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="502" mass="57062" checksum="99FCC39F5B93C645" modified="2007-02-06" version="1">MGEEYMRGNGAAGEEVEKVVREEVWRRAALSLYTTRTEDKRRSRGKKKRGEIHYRGLHDAVTEINWDFTRFAAHALSVVPDEVYPRFYRFIDSDARKYLLLSDDNRPREGSAVTELRGRLQAIVDATEDGLRAERHGRHWRVYVPRENWYVVVSKPARWVVRIPLKGFWTESEFPRVLVNTPSDVLRSLQRGWLLTDVTPPHEGYPYVSFGTTQAWQLPSTLAAFPSDDVRLGVTAGILGSTRLSLQWGVSIYGYEEELGWASGLIGEVKRAEFRRLVEECKELNGDSVALATAFLGDGELEYFLRLRWLYFRVGHEHVYLPTESAVFNARVAVERASEYVAFVGKVTRCAKVRHILFVAYGAPGKRGRKPGQKVGSYQELGLYAPVAGALLNLVMVAVGGKYAYIYARIPVDSAPQGWYQRAVEEGWTVKVVRSRVKSRAHTTREMLYYEIPQSSLFEHAAEDATLWEALYRFAVAKAQAKPVARKLVEELLRIKPAGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM7</accession>
    <name>A1RXM7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77957">
        <property type="protein sequence ID" value="ABL77957"/>
        <property type="gene ID" value="Tpen_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0551"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="472" mass="54977" checksum="4BFCC0BCC6580A0A" modified="2007-02-06" version="1">MNEVVMRGDGAGEGVEEFDEWFIRRKIEELLRKALFPPSGYRGLKATHSKVARELAEIKANYVQYGEAYVEHVDRLREGEEKAYREAEKAMQEALEHADELEIKRTGKTTWKAKLPGRRWRLYVCRTPTGHWQVEVALLFKVAELRLSDTLRLPPELLRAAQDGWILGDASYIANKKEVKMGTAQTWQVASFPGFWPGKEVVIYVRSVVIHESHVSIMWQVRVHGVRDVPRWWRLRKEEKRRMAVAEIEEANKGNIDERRAVRIATYYAADGKYPGSNSALHYLDFAVGRRSRRVRTEQSVRVARLLYEKVPQLLAFMVASGCKKAEFLASLASVKPRHYAPRYLEVCGVKMNLRLAGPKNRRYLMAQVYITRNNEEMLRDFPERARREGLEVRRVKVSKRYWGYRAGEKSLMKYADRYPHVYDTLIEFVQEELQATPPDHPARRSIERLLERLRKAKEEALKKLGHQDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP7</accession>
    <name>A1RXP7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate ferredoxin oxidoreductase, delta subunit</fullName>
            <ecNumber evidence="4">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0572"/>
    <dbReference type="EnsemblBacteria" id="ABL77977">
        <property type="protein sequence ID" value="ABL77977"/>
        <property type="gene ID" value="Tpen_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0572"/>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="GSWRTFK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="98" mass="10734" checksum="592AC15C62BFA4A6" modified="2007-02-06" version="1">MSEASSFVLKSWREMPPGGIIPVPKTSLLNKTGTWRALKPVINQAKCIRCLMCWVHCPEPAILRGEDDSVAVDYDYCKGCGICANVCPVHAIEMVPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS5</accession>
    <name>A1RXS5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0600"/>
    <dbReference type="EnsemblBacteria" id="ABL78005">
        <property type="protein sequence ID" value="ABL78005"/>
        <property type="gene ID" value="Tpen_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0600"/>
    <dbReference type="eggNOG" id="arCOG01269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_0_2"/>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="32100" checksum="C7F5C9C6C3C6EEA2" modified="2007-02-06" version="1">MLMLALLVDALVYGNLLALLSVGLSLTLLTTEVSNFAHGDFAVIGIYIAYTLSQVLNVTPYAFIPVAFAGGALVGLAVYFLVFDPLRDKASFVTLMIVSMALEFILRYSVQIYADVMQRLLKTFGRGFMFNDVRLALLGLHVDGVVVYSSITTLSLLVLLYVFLYRTKTGTAMRAAIENPQLAQTLGINVKKVYAYSWMLSAGFAAAAGVFLPFKIVVNPDTGFSLLLSMFAAVTVGGLGSLAGSLVGAYLISFSEIAATYFLSSLGLSTSYRALVSFLSIAVVLLLSPRGLAGLWSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU5</accession>
    <name>A1RXU5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0621"/>
    <dbReference type="EnsemblBacteria" id="ABL78025">
        <property type="protein sequence ID" value="ABL78025"/>
        <property type="gene ID" value="Tpen_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0621"/>
    <dbReference type="eggNOG" id="arCOG00545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OMA" id="FYIDPWR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="317" mass="35058" checksum="9D03C9E4A4F5B081" modified="2007-02-06" version="1">MLVDHGVVVQGGRATVVFDPTRTPALKPSVVIVSHAHSDHYSLRALRSLPNTPIVMSRATREIIDPSLRLRNVVYIEDGEEVEVEGVRIDAFSSGHIVGSLQFLIELEGKRIVFTGDFNLEKRLVLKPASVVRADVVIIDGTYGSPEYVFPPRTELYRGLVEFVKSRMEEGTPVLLKGRRVGVAQELTALMYMSMDVVPLVEESVASVNRVYEKYGEWLGKYAPWVGSIPERAGPVITHLASRHDARLPHCLCTGWAVKGGGFPLSSHADFSQIVRYVRDSGAEVAIPFCGYRSELAESLKRLLGVEAYAEREVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV2</accession>
    <name>A1RXV2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="3">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="3">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspS</name>
        <name evidence="5" type="ordered locus">Tpen_0628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752297.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0628"/>
    <dbReference type="EnsemblBacteria" id="ABL78032">
        <property type="protein sequence ID" value="ABL78032"/>
        <property type="gene ID" value="Tpen_0628"/>
    </dbReference>
    <dbReference type="GeneID" id="4601415"/>
    <dbReference type="KEGG" id="tpe:Tpen_0628"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="24288at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="127"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="3">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA discrimination" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="421" mass="47632" checksum="2A81521D2B9CA8E6" modified="2007-02-06" version="1">MSSEGVIEGWVSNVKILGKIAFIEVIDGLNLSPITVVVRKDSGSVDWSKVSAVKLGSAIRVKGVYPEKVVSKKGREIHADEIEILAEPRDLPPIDVTGKTPASFEDYINYRYLALRLPRVRAAFLARSLIVNEIRSFFSERGFLEVHTPKIVKAGAEGGATLFEVDYFGVKAYLAQSPQLYKQMLMCGVPRVFEIGPFFRAEKFSTTRHLNESWGLDVEMGFIKGMEDVLEVLSQLVVHLSHKLNERLGDALRGLGYNVIKPVTSVRVLTYDEALEVLNSLGFNLKWGEDFDPKAEKSLGDYLEEKGVQAYFIVDYPWESKPFYIMKKDEKRGYAFDLDIRGIEVASGGQREHRYEVLRQNLLEKGLNPEDFSFYLEAFKYGMPPHGGFGLGIDRLVMTFLGVQNIRETVLFPRDRFRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXV9</accession>
    <name>A1RXV9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0636"/>
    <dbReference type="EnsemblBacteria" id="ABL78039">
        <property type="protein sequence ID" value="ABL78039"/>
        <property type="gene ID" value="Tpen_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0636"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073311_1_1_2"/>
    <dbReference type="OMA" id="DYFDYEI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="277" mass="29206" checksum="FD42CDB326700202" modified="2007-02-06" version="1">MHARVKAFLRLSRIEHGVMSGLAVIAGALSTQVFVADKAVLAALSAFFAETSLFAFNDVFNVEEDKVNNPTRPIVAGEISLREALLFAIATGIMSVVFASAIGPFPLAVIALALGLGILYDAMLKRHGFLGNLIVAGLTAFTFPFGAIAVTASPTEKSLLFFAVAFLANVGREIVKGIRDLEGDMKAGICTLPCEVGEKPAGVIAAAFMSLAVVLSFSGLAFVSLKHLYLALILVTDVIFAYSAAVMALKADRHHAEVARRITLPAMLLAIVAFTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX6</accession>
    <name>A1RXX6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase, DHHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0654"/>
    <dbReference type="EnsemblBacteria" id="ABL78056">
        <property type="protein sequence ID" value="ABL78056"/>
        <property type="gene ID" value="Tpen_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0654"/>
    <dbReference type="eggNOG" id="arCOG01565">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070736_0_0_2"/>
    <dbReference type="OMA" id="CHHNADP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="196"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="330" mass="35379" checksum="3E58D6A3C2C71D34" modified="2007-02-06" version="1">MKLREFLSTLRGAVVVTSHVNTDPDGLACAYLMARLVEEVGLEAHLCFPGGISSVSKTILGRLGMSWQRECPEDTRTFILCDFSNPSQLRELAEKFSDPSVTLVVVDHHFPEGKLVPLAKLAVVEREPASAVIAARILMDEGVNVCATLATLGIAGILYDTKKLLFASSNTFRVLSWLLDSGGDYRLAHSLLVEEEPRSEKLAKLKGLLRASVFEVCGYIVAFTEVSANEANVARLLVSAGADLAVVVGGKKESRLSIRVSDELQKAGIDAGEIAQSVASALGAEGGGHAGAAGVKTTDRKAHGRMSRAIVNEVIERLFRYLCTQRSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ0</accession>
    <name>A1RXZ0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752335.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0668"/>
    <dbReference type="EnsemblBacteria" id="ABL78070">
        <property type="protein sequence ID" value="ABL78070"/>
        <property type="gene ID" value="Tpen_0668"/>
    </dbReference>
    <dbReference type="GeneID" id="4601034"/>
    <dbReference type="KEGG" id="tpe:Tpen_0668"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_1_3_2"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8490" checksum="BB8611140683A677" modified="2007-02-06" version="1">MVKGYILINTRPGKEYDVANQLKTFPFVNDVDITYGLWDIIIKIQAPSLAELDKIISMVRGLKDVEQTVTLVAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ3</accession>
    <name>A1RXZ3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752338.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0671"/>
    <dbReference type="EnsemblBacteria" id="ABL78073">
        <property type="protein sequence ID" value="ABL78073"/>
        <property type="gene ID" value="Tpen_0671"/>
    </dbReference>
    <dbReference type="GeneID" id="4601037"/>
    <dbReference type="KEGG" id="tpe:Tpen_0671"/>
    <dbReference type="HOGENOM" id="CLU_2519953_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="84" mass="8894" checksum="CC66249D48AA088A" modified="2007-02-06" version="1">MVSVVRFFVLVALASLLVSARLTGEHATTHAGTCFCLAEVQRGARVKPLSNNCPMVLLVEFEPASGGSTERLVLCDGYVKIGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ8</accession>
    <name>A1RXZ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0676"/>
    <dbReference type="EnsemblBacteria" id="ABL78078">
        <property type="protein sequence ID" value="ABL78078"/>
        <property type="gene ID" value="Tpen_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0676"/>
    <dbReference type="HOGENOM" id="CLU_1431714_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="188" mass="21189" checksum="69786984711484F1" modified="2007-02-06" version="1">MKRRRAAIGLLAVALLSLAVLQNSRSSSEVRVLYYGENVYMAYLAAAREACASNMSVEELVDGLSDYFGPLRLADTRVARFERSDKLSGVKYCNVTVTTKLGARASFELNYTYTFLGFFAETGTGRIVKVYRINAYQRFKIPEYRYAILLQVDLVPTCESITYNGTLEVRIDTPCVLRDKWGFTLTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY64</accession>
    <name>A1RY64_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0742"/>
    <dbReference type="EnsemblBacteria" id="ABL78144">
        <property type="protein sequence ID" value="ABL78144"/>
        <property type="gene ID" value="Tpen_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0742"/>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240198_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1711" mass="182985" checksum="80D32F5A7383FB0B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY72</accession>
    <name>DNLI2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase 2</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [ATP] 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lig2</name>
        <name type="ordered locus">Tpen_0750</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752417.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY72"/>
    <dbReference type="SMR" id="A1RY72"/>
    <dbReference type="STRING" id="368408.Tpen_0750"/>
    <dbReference type="PRIDE" id="A1RY72"/>
    <dbReference type="EnsemblBacteria" id="ABL78152">
        <property type="protein sequence ID" value="ABL78152"/>
        <property type="gene ID" value="Tpen_0750"/>
    </dbReference>
    <dbReference type="GeneID" id="4600401"/>
    <dbReference type="KEGG" id="tpe:Tpen_0750"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="52275at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000365266" description="DNA ligase 2">
        <location>
            <begin position="1"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <sequence length="601" mass="66943" checksum="8AA565878E7AF78B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY73</accession>
    <name>A1RY73_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752418.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0751"/>
    <dbReference type="EnsemblBacteria" id="ABL78153">
        <property type="protein sequence ID" value="ABL78153"/>
        <property type="gene ID" value="Tpen_0751"/>
    </dbReference>
    <dbReference type="GeneID" id="4600402"/>
    <dbReference type="KEGG" id="tpe:Tpen_0751"/>
    <dbReference type="eggNOG" id="arCOG05463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124258_0_0_2"/>
    <dbReference type="OMA" id="IYNYRTE"/>
    <dbReference type="OrthoDB" id="113421at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="189" mass="21498" checksum="3E71666A057914AE" modified="2007-02-06" version="1">MADSAKELAEVKSYLEKRLEELRREERLIESMLKLVDEALSSASFVKASELVAARQPEAAEARQAVARHTVEEKPTEESLVTATASGEHLARVLVYPSRVEIVFLKPLSSGTSPFQSFFVKKLLEGFKRQDEDLVARGEKSPDEVFDYRIEEEGGVLKRVVIENYGDKERVREIKSALRWTLNKMIQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA7</accession>
    <name>A1RYA7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752452.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0785"/>
    <dbReference type="EnsemblBacteria" id="ABL78187">
        <property type="protein sequence ID" value="ABL78187"/>
        <property type="gene ID" value="Tpen_0785"/>
    </dbReference>
    <dbReference type="GeneID" id="4601133"/>
    <dbReference type="KEGG" id="tpe:Tpen_0785"/>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435243_0_0_2"/>
    <dbReference type="OrthoDB" id="88473at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="628" mass="67537" checksum="25E766AF89B0DAAB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC1</accession>
    <name>A1RYC1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752466.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0799"/>
    <dbReference type="EnsemblBacteria" id="ABL78201">
        <property type="protein sequence ID" value="ABL78201"/>
        <property type="gene ID" value="Tpen_0799"/>
    </dbReference>
    <dbReference type="GeneID" id="4601260"/>
    <dbReference type="KEGG" id="tpe:Tpen_0799"/>
    <dbReference type="eggNOG" id="arCOG14823">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346475_0_0_2"/>
    <dbReference type="OrthoDB" id="126069at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="204" mass="23325" checksum="18D679512114AFD1" modified="2007-02-06" version="1">MSYESPREKAQKRAKLLKRIVEDLDAIRALRLFNTSDTIRLISRAGLEDELWEKTKSSLREIALILVNHPDFRKIERADRISTYMFVASFVASLTALILMLLNVNIVLSYLVLLASLIILNASYIGKLYVGVSVRRVYMERRSDVEKHGELLKKAAENALSKLRGELRKAGMDPSQVTFKLYFNDYSPLKQVGSSKGMHKLTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD2</accession>
    <name>A1RYD2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752477.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0811"/>
    <dbReference type="EnsemblBacteria" id="ABL78212">
        <property type="protein sequence ID" value="ABL78212"/>
        <property type="gene ID" value="Tpen_0811"/>
    </dbReference>
    <dbReference type="GeneID" id="4602142"/>
    <dbReference type="KEGG" id="tpe:Tpen_0811"/>
    <dbReference type="eggNOG" id="arCOG04102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165385_0_0_2"/>
    <dbReference type="OrthoDB" id="118811at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="113" mass="12610" checksum="415D82C9327A28C7" modified="2007-02-06" version="1">MEALSVVVIGSSPTVDSLRLLGFEVVRVPEKLGKAEEDEVVAKILESRVALVESEVYASVAERLRQVMSFVKEPPLLVVIPSSEKASTRRLEELYNKLSMALGVRLRWAKKEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD4</accession>
    <name>VATE_THEPD</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">Tpen_0813</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752479.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYD4"/>
    <dbReference type="SMR" id="A1RYD4"/>
    <dbReference type="STRING" id="368408.Tpen_0813"/>
    <dbReference type="EnsemblBacteria" id="ABL78214">
        <property type="protein sequence ID" value="ABL78214"/>
        <property type="gene ID" value="Tpen_0813"/>
    </dbReference>
    <dbReference type="GeneID" id="4601983"/>
    <dbReference type="KEGG" id="tpe:Tpen_0813"/>
    <dbReference type="eggNOG" id="arCOG00869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1307877_0_0_2"/>
    <dbReference type="OrthoDB" id="136866at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000322537" description="V-type ATP synthase subunit E">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <sequence length="215" mass="24019" checksum="B21D6DDC063A0402" modified="2007-02-06" version="1">MRGVAEEKTLLEVIIQELRRAAEEESRRIVKEAEQEAQKIVEEAIQKAEAIKAEKLNQLLNEYRQKAMAELAPKRLELRHRAIREKHELIESALNRAIEEAVKTILGNDDYRRTFLEKSLEKGVVALSSTDLVVHPCRGSASIVGQVVEAVAARLSKVKPGLRLEIGDPLGCTEGVVIVSRDGREIYNATLEAKIAEVRESVKPKVLELVSRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE2</accession>
    <name>A1RYE2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0821"/>
    <dbReference type="EnsemblBacteria" id="ABL78222">
        <property type="protein sequence ID" value="ABL78222"/>
        <property type="gene ID" value="Tpen_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0821"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="TNCCLKA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="36"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="398" mass="43594" checksum="D313D13A61E29539" modified="2007-02-06" version="1">MRAALVTADFAPRPGYKITQDEIRTHKVREGAKVWRNPKLVLRTDYPVPEPKPDEILIRVKAVGICGSDIHFLETDSEGYILYPGLTRFPVVIGHEFSGVVEKVGTNVKTFKPGDMVTSEEMFWCGECDACRSVDFNHCLRLNDPADLEFGELGFTHDGAMADYVVVKAKYAWKIDSLLDRYGSEDKAFEAGSLVEPTSVAYHAMFTRAGGFKPGAYVAVWGAGPIGLAAIALAKAAGAGKVIAFEVSPTRRELAKKVGADYVFNPVELSKNGVEPWEKIMEVTGGQGADFHVEAAGAPRHTIPQMQKSLAINGKIVQIGRAAEDVPIYLEVFQVRRGQIFGSQGHSGFGNFGNVIRLMAAGKIDMTQIITARFSLDEVYKAFERAHQRIDGKITLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYF1</accession>
    <name>A1RYF1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0830"/>
    <dbReference type="MEROPS" id="S49.005"/>
    <dbReference type="EnsemblBacteria" id="ABL78231">
        <property type="protein sequence ID" value="ABL78231"/>
        <property type="gene ID" value="Tpen_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0830"/>
    <dbReference type="eggNOG" id="arCOG01910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_1_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="410" mass="43515" checksum="D87263BBA141B9DD" modified="2007-02-06" version="1">MKGRVGVFIAFSVFLLLCAVAYAQPRVVVVDLEGRIDEGAYYTVKRGLEEADKGVVVVVIRSYGGYLKSMDKIVELLVSSEARTIAWVPPGERTVSAAAVIALSAQRLYMGKGAVIGSIKPYPDDPKTVEYVVARVAALLSKKGVNDSRGLARRLVVDAQSFTSDEAVATGIADGTADSLAELLQKEGLSFASVHYVSGDLVSDLLSVLLDPALAVLLALLGAMLLLLEFKVTGFQGWGVIGAALIVISLYSFDVIGVSLSTFILALLGITLIIVELAKPGVQVAGIAGVALIALAVILEYASRPYPVFTPNVLVVAVPLAILVLLLAVVISKALETVRMKAPSLQERLIGKIGVAKTRIEPGKRGVVYVDGEDWTATSEYVVEEGESVEVVALDGLFLKVKPVRREHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYI0</accession>
    <name>A1RYI0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0859"/>
    <dbReference type="EnsemblBacteria" id="ABL78260">
        <property type="protein sequence ID" value="ABL78260"/>
        <property type="gene ID" value="Tpen_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0859"/>
    <dbReference type="eggNOG" id="arCOG01481">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_0_0_2"/>
    <dbReference type="OMA" id="EVRWTLD"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_C" evidence="8">
        <location>
            <begin position="130"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="413" mass="45825" checksum="CE2D354DBF198842" modified="2007-02-06" version="1">MAQRSEAWEKRFIYATFDEIKAGLTTDIYFVRTRRILEKYGLLDAEVHMEVTASRLPEDYRWGVFAGLREVLKLLEGKRVTVRALPEGTLFKAQDYYGYKIPVLTVEGPYGEFVELETPLLGFLASASGIATKAARVKKAAGDKLVLSFGARRQHPALAPFVEFYAYIGGADAVSAVLGAEALGIKPTGTMPHSLLIIFRAFKGDHSLGWKAFDEVIEKDVARVALADTFFDETEEVVLAAKTLGEKLWGVRLDTPGSRRGNFEDIIREVRWRLDTLGYKHVKIVVSGGIDEYRIPSLARAGADAFGVGAAISTAPPIDFAMDITAVKREGRWVPISKRGKLPGKKQVYRCDKCMVDVVVLEGSEPPVCPKCGAQMEPLLETFIEDGRPTKRVESPQEVRARVLEQLSRLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ1</accession>
    <name>A1RYJ1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0870"/>
    <dbReference type="EnsemblBacteria" id="ABL78271">
        <property type="protein sequence ID" value="ABL78271"/>
        <property type="gene ID" value="Tpen_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0870"/>
    <dbReference type="eggNOG" id="arCOG04463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_948702_0_0_2"/>
    <dbReference type="OMA" id="WGYGPAL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PTHR10202"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="31604" checksum="2ED7E0DC69EAA73D" modified="2007-02-06" version="1">MEENVREIGRSTVASMLAVAVVVSLLSAVWALVLVSSGITEVLGSPFVYEEGPRGAIVNSVLTLLLVLLGTGVLLAMIKLRKARFIPALTAFAVAFSFWGISELYFYAFSAFDQRILPIADATSILLAVTTGALILKPVNATLLNALLIAYGTMAGALLFATLPSWSVFGIAVVLAAYDLYSVFRGPLKKILESTIAQEQAPADKLHSPLRGSVVVIRGLALGMGDVLVYSMLSPAFLLYPRVSVERWILSNLALTAGLYATLEMLKRRRYMPALPLPVAFSVAAYLAYTLVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYJ2</accession>
    <name>A1RYJ2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0871"/>
    <dbReference type="EnsemblBacteria" id="ABL78272">
        <property type="protein sequence ID" value="ABL78272"/>
        <property type="gene ID" value="Tpen_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0871"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_2_2"/>
    <dbReference type="OMA" id="YHNCISG"/>
    <dbReference type="OrthoDB" id="58376at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="390" mass="43033" checksum="BBF5756AB16167AD" modified="2007-02-06" version="1">MILANPSALSSRYVPRRLPHREPQIERLASLFPELPKAPFFRVVQLIGPTGTGKTSTSLFFARSVEQQSENVSTIYVNLKSLRSRDADGFPWIVYTSILSQLGAKPSRSLSAAEVFMKVVGELSRRQKKLHLVIVDEADELTGPRSLQGGQIVYNLTRLPELGVSNVAGVIFIARNDDWARGLAPEEKSSLGALVVRFPPYTLSQLVDILLYRASEALASPEALPEPVAEYIAEITVDMFERDVRKALDVLLYSALIADKEGSDKITRLHVTRALAEIMGRSYLDDDAAKMLGRTERIVLAAALRAAGSSDTIYVSEQRVLEEAQAICERLGIPPLGRREIATALQRLHDLGYIKVSGPLKIFVNLVAGENVEELLLGNTLRKARGSYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK8</accession>
    <name>A1RYK8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752553.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0887"/>
    <dbReference type="EnsemblBacteria" id="ABL78288">
        <property type="protein sequence ID" value="ABL78288"/>
        <property type="gene ID" value="Tpen_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="58787001"/>
    <dbReference type="KEGG" id="tpe:Tpen_0887"/>
    <dbReference type="HOGENOM" id="CLU_1352167_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="22382" checksum="CBE415819E23ED58" modified="2007-02-06" version="1">MNRDYDPCDELSLEIVASGEGYEVALKVSRHLAEICPRIEQLGSLLGMARRNHEFTKTVGRSELAPLLSELSRLLGELSEECTVLRPGLSVGGLLHALEKRGWLAEASGNSVETRRVLGEGRVRVDVRCTIVSSFLVRVQLRVKVPVGSVAEGEEARRRFLLAGYRVSSSFPVLTAEKELFPVFLCNVAEVLDKEMGEMERI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYM3</accession>
    <name>SYC_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">Tpen_0902</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYM3"/>
    <dbReference type="SMR" id="A1RYM3"/>
    <dbReference type="STRING" id="368408.Tpen_0902"/>
    <dbReference type="PRIDE" id="A1RYM3"/>
    <dbReference type="EnsemblBacteria" id="ABL78303">
        <property type="protein sequence ID" value="ABL78303"/>
        <property type="gene ID" value="Tpen_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0902"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000332922" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="474" mass="54914" checksum="EFF9FEB2A2C6F0C5" modified="2007-02-06" version="1">MLRVYNTLSRSLEVFEPVEEGRVSIYVCGPTVYDYSHVGHARTYVAFDVIKRYLRLRGYDVVHVQNITDIDDKIINRARDEGRDWREIVDEYTKDYLEALQKLRVLVDVHPRVTEHISEIIDFVQKLIDSGHAYVAPSGSVYFDVDTYPDYGRLSGRLDKKMWSQEEFASEKKNPYDFALWKARKPGEPYWDSPWGPGRPGWHIECSVMSSKYLGRRFDIHGGGTDLIFPHHENERAQSEALFGEKPWVKYWMHTGMLQVRGEKMSKSLKNIVPLRDLFRSYDPLVVRLWLATAHYRTVLQFSDEVLEQAKSNLQRLRGAVQLLKNLAKEVEPEGRLSDWELGVFREMLDARREFYASMDDDFNASGAFAAVMKLTGLVYSQVSAKPTYLLVLRALRLFEEFNRVLGVLDEDLALGAAEVLPVDELLDLIVEVRAKLREQKNYELADYIRSKLSSLGVQLMDQGEKTRWILTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ3</accession>
    <name>A1RYQ3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Membrane integrase YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752598.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0932"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78333">
        <property type="protein sequence ID" value="ABL78333"/>
        <property type="gene ID" value="Tpen_0932"/>
    </dbReference>
    <dbReference type="GeneID" id="4600755"/>
    <dbReference type="KEGG" id="tpe:Tpen_0932"/>
    <dbReference type="eggNOG" id="arCOG03284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272220_0_0_2"/>
    <dbReference type="OrthoDB" id="71654at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_57" evidence="10">
        <location>
            <begin position="797"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1128"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131050" checksum="F3302C1E5154B746" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT8</accession>
    <name>A1RYT8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752633.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0968"/>
    <dbReference type="EnsemblBacteria" id="ABL78368">
        <property type="protein sequence ID" value="ABL78368"/>
        <property type="gene ID" value="Tpen_0968"/>
    </dbReference>
    <dbReference type="GeneID" id="4600442"/>
    <dbReference type="KEGG" id="tpe:Tpen_0968"/>
    <dbReference type="eggNOG" id="arCOG06985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192649_0_0_2"/>
    <dbReference type="OMA" id="PWRFRFY"/>
    <dbReference type="OrthoDB" id="129023at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="72" mass="8439" checksum="BCB1D39DA0C7AB48" modified="2007-02-06" version="1">MAKVELLVECPHCGYSDRLDSFKLLRDPWRYSFYEVRRLQCPKCGGTFNYYYGVSPKGELSTFTIRFKTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU8</accession>
    <name>A1RYU8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78378">
        <property type="protein sequence ID" value="ABL78378"/>
        <property type="gene ID" value="Tpen_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0978"/>
    <dbReference type="eggNOG" id="arCOG08620">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124456_3_1_2"/>
    <dbReference type="OrthoDB" id="140116at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="105" mass="12009" checksum="B2C36BEC460989C1" modified="2007-02-06" version="1">MEGYISALTVVIIYFLGARTLSEAESREVTKRAIRGFNIVSMSEDVIKKALGENRIKDLEDAIQFHSAKEVADVLITRNKRDFRAVEDEEIEVLTPEEFLEKYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV3</accession>
    <name>A1RYV3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752648.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0983"/>
    <dbReference type="EnsemblBacteria" id="ABL78383">
        <property type="protein sequence ID" value="ABL78383"/>
        <property type="gene ID" value="Tpen_0983"/>
    </dbReference>
    <dbReference type="GeneID" id="4600457"/>
    <dbReference type="KEGG" id="tpe:Tpen_0983"/>
    <dbReference type="eggNOG" id="arCOG00887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295544_0_0_2"/>
    <dbReference type="OMA" id="RENARFF"/>
    <dbReference type="OrthoDB" id="12805at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115450" checksum="BD9AF7FFEE8F6C97" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYV4</accession>
    <name>A1RYV4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752649.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0984"/>
    <dbReference type="EnsemblBacteria" id="ABL78384">
        <property type="protein sequence ID" value="ABL78384"/>
        <property type="gene ID" value="Tpen_0984"/>
    </dbReference>
    <dbReference type="GeneID" id="4600458"/>
    <dbReference type="KEGG" id="tpe:Tpen_0984"/>
    <dbReference type="eggNOG" id="arCOG11435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056188_0_0_2"/>
    <dbReference type="OMA" id="FLYRMWL"/>
    <dbReference type="OrthoDB" id="138444at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="132" mass="15199" checksum="86EA11387EBEC7BB" modified="2007-02-06" version="1">MLIRAIRGGRAVRVKCAEGRFEVGVPFEELFSFLGRIYPWELERHIEVGDGVAEFRERIPFERALAYLLARRGRLSQKDAELVAAGIRQHELSAIVDSFLYRMWLCRVDGRSCKEVVDAFSKIVAVYRKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ21</accession>
    <name>A1RZ21_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752716.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1051"/>
    <dbReference type="EnsemblBacteria" id="ABL78451">
        <property type="protein sequence ID" value="ABL78451"/>
        <property type="gene ID" value="Tpen_1051"/>
    </dbReference>
    <dbReference type="GeneID" id="4600794"/>
    <dbReference type="KEGG" id="tpe:Tpen_1051"/>
    <dbReference type="eggNOG" id="arCOG04263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081191_0_0_2"/>
    <dbReference type="OMA" id="MLGETVF"/>
    <dbReference type="OrthoDB" id="117822at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="214"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="296" mass="30670" checksum="2F821070DE417D12" modified="2007-02-06" version="1">MRCAKAWSPAGLSGLFETHIVEGDYLATGARGAGLALKKGVLVEACLTGGEGVRVEVSNGVRIMPTVETVARDLLARAGLSGGLEVRVDVSVPVGGGLGTSGASALATALALGKLLGLKLGYMELARVAHVAEVKNRTGLGTVSGLVVGGAVVVLKPGAPGFDAVDRILFDDVKVVVGFFGAVPKPSILSSKNLAEIDRVGRRLVDELAREMTIEKFAEVSKRFSLETGLATPNVRKAFKLAEELGAVGAGQAQIGDTAFLLVYEDKVERASRALSEMGARVVVSEISWEPAHVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ26</accession>
    <name>A1RZ26_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1056"/>
    <dbReference type="EnsemblBacteria" id="ABL78456">
        <property type="protein sequence ID" value="ABL78456"/>
        <property type="gene ID" value="Tpen_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1056"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_2"/>
    <dbReference type="OMA" id="FGNNQFF"/>
    <dbReference type="OrthoDB" id="42250at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="313" mass="35504" checksum="120A78AB3D741B59" modified="2007-02-06" version="1">MPVSSVKKYSAPILFLLPALVVLAMVSFYPLVFGFYMAFTDMSTTKGKWISWDFVGLENFRRIVEELLTPELGLGRALLNTVFFTVVNVALQVLVGVAFAFMLNSDKLLWRRFWQAVFIVPWAVPGYISIMAWFFLYQYSYGYFNQILMNLGLERIDWLGQRLDTFWPWVSINATNVWLAYPFIMTVTLAALQTLPRDLLDAAKVDGAGGWQTFRYVVLPHIKPPLTIATVLTTITTFQQFGVVWLLTGGGPQIFVKAIGTTIYVTDLLMTYGYRTIWQFGDYGYGAAFSIFLALLVVPASIYAMKKLRVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ32</accession>
    <name>A1RZ32_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752727.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1063"/>
    <dbReference type="EnsemblBacteria" id="ABL78462">
        <property type="protein sequence ID" value="ABL78462"/>
        <property type="gene ID" value="Tpen_1063"/>
    </dbReference>
    <dbReference type="GeneID" id="4601449"/>
    <dbReference type="KEGG" id="tpe:Tpen_1063"/>
    <dbReference type="eggNOG" id="arCOG00700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759967_0_0_2"/>
    <dbReference type="OMA" id="HCMEVED"/>
    <dbReference type="OrthoDB" id="61250at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="365" mass="40473" checksum="F3D19D0800455E0E" modified="2007-02-06" version="1">MGVVEVGELFAGGRVLERARLVMPGVSEDFYFESAVSPGFSDAHAHPQVVDVGEGGRWRNSYEWIEGRRLRVNEASLRRDAETSAELAEVALLLSLLDGVTLVALTGSLEGNIEAVRRLKVAPRTVLLPTVMRGEGWSLPESIYVKYVKNLSMWDGYYSLGFFVHSLRMADRSMLRASKRMAERLGVPFALHLSEGVDEADELVEALEGDTRGVIAVHCFEGAEKCRRHGLRVVHCPTSNLYLYGRTLRGLEYFDSLGSDWPLVTGTLLKTYGDAVAVHGPSYRLLERATLGGYLLLGFKPEGDLAAFDEPLSRVVRGEARPSHVFIGGRLLVREGVIAGYELGRDDVERVKRERVKRAFEKHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ41</accession>
    <name>A1RZ41_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752736.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1072"/>
    <dbReference type="EnsemblBacteria" id="ABL78471">
        <property type="protein sequence ID" value="ABL78471"/>
        <property type="gene ID" value="Tpen_1072"/>
    </dbReference>
    <dbReference type="GeneID" id="4601650"/>
    <dbReference type="KEGG" id="tpe:Tpen_1072"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103623_0_0_2"/>
    <dbReference type="OMA" id="FVMLEIT"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="233" mass="25646" checksum="E9109446096BC731" modified="2007-02-06" version="1">MNKYRSKLEILKTAVKSLLQPPLTVPYTGHLNNSFIRGAPLLDRDKCLGCSLCARSCPSGAITMVPGGKKVVGGKEVERKIPSFNYYQCIYCGVCAEVCPGRAISMVKKQPVEIISLASLLPLATGEPEALKVLFSFLLLLVAVSFAYWLSGRVAARGKHTEKAREPFTGGVAPRLPTYRYHVEELYTFVILFVMLEITAFTMILERDASVILPCLLFLAYLLLLASPATRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ63</accession>
    <name>A1RZ63_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752758.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1094"/>
    <dbReference type="EnsemblBacteria" id="ABL78493">
        <property type="protein sequence ID" value="ABL78493"/>
        <property type="gene ID" value="Tpen_1094"/>
    </dbReference>
    <dbReference type="GeneID" id="4600961"/>
    <dbReference type="KEGG" id="tpe:Tpen_1094"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OMA" id="THPLTDC"/>
    <dbReference type="OrthoDB" id="29945at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="455"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="609" mass="65060" checksum="28848B9080145633" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB7</accession>
    <name>A1RZB7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752812.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1149"/>
    <dbReference type="EnsemblBacteria" id="ABL78547">
        <property type="protein sequence ID" value="ABL78547"/>
        <property type="gene ID" value="Tpen_1149"/>
    </dbReference>
    <dbReference type="GeneID" id="4600955"/>
    <dbReference type="KEGG" id="tpe:Tpen_1149"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="SPKAFLM"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="40063" checksum="0BDDD78764806EB7" modified="2007-02-06" version="1">MSVELRNVTKRFGEVAAVYNVNLRVESGEFFVLLGPSGSGKSTLLRIIAGLEEPDEGEVIIGGRVVNDVDPSERDIAFVFQNYALYPHMTVYDNIAFPLRMRKVPKDQIHARVLEVASMLGLTNHLSKYPYQLSGGEQQRVALARAIVRKPRVFLLDEPLSNLDAKLRVKLRFELRKLLHDELKTTTIYVTHDQVEAMTMADRVGVINRGQLVQVGTPDELFEKPSNTFVAGFIGTPPMNFLPARVAEKTLRLGNLAIRSEELEGLAEGEVILGIRPQHLEVGEEGLPVRVVGVERLGTGSILHGVFEGFEVTAYSEKREHAQPELNAEVRLKPVGPLYLFDSRSEELLRVVRSYRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI6</accession>
    <name>A1RZI6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ordered locus">Tpen_1218</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752881.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1218"/>
    <dbReference type="EnsemblBacteria" id="ABL78616">
        <property type="protein sequence ID" value="ABL78616"/>
        <property type="gene ID" value="Tpen_1218"/>
    </dbReference>
    <dbReference type="GeneID" id="4601630"/>
    <dbReference type="KEGG" id="tpe:Tpen_1218"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_4_2_2"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="OrthoDB" id="62484at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="140"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="372" mass="40056" checksum="45F2FD2F381106B6" modified="2007-02-06" version="1">MKEKLLLVLSLASVALIFSLLLQALVPVSGFYGPVGAWWALDFIGYALAMAVLVTAPSLFGKYLTPTPSNLGVLRSSMIATMAGVLGGFGLVALGVSSLLGAELTGQLLSLAIVFALVPSLFSWLFSPLLINVMYGCKPDPVLQDIVNRVAQRAGMKPPKAVIATRMREPNAFAYSSPLFGSYVAVTEGMMRLAKGEELEAVIGHELGHHKHKDNTVMLIFGLIPSVVYFLGRFLAYMGFFSSGARYDGDGERRGGGGGFLLVLVGIALMAVSVIIQLAVLALSRLREHYADVHGAMVTSPDAMISALASLDSYYGSREVAKRRVEDSKLKMFFIYALAEPLVSLEELLATHPPIEKRIAFLEALKRTSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZI8</accession>
    <name>A1RZI8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752883.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1220"/>
    <dbReference type="EnsemblBacteria" id="ABL78618">
        <property type="protein sequence ID" value="ABL78618"/>
        <property type="gene ID" value="Tpen_1220"/>
    </dbReference>
    <dbReference type="GeneID" id="4601717"/>
    <dbReference type="KEGG" id="tpe:Tpen_1220"/>
    <dbReference type="eggNOG" id="arCOG10867">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596691_0_0_2"/>
    <dbReference type="OrthoDB" id="144493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="458" mass="52670" checksum="7D6EFB384D944DB4" modified="2007-02-06" version="1">MKEDEAVAAGEAGAEFDEEFVRGKLRELLRKALFHRYNYRGLEATHNKVMWELINIKANYARYGEAYVELVNKFEVGKEKAFRIARKVAKEALERIDELEIKRTGKTTWQVKLPGERWRVYIYLKPSGKWCVEIRLYIKVAKLRLPDILKLPPEWLRIAQEGWVFGDATYRARYREIAMTTSQAWQVASFPGFWPGKEVEVHIKSIAIHEKRHVSIMWTVKVKGVCNVPRVWSFPKVVKQRIIVDEIEKANEGEIDEQRALKLALLYAADGEYPGSNSARRVLEFAVGRRSRWIRTEQSVRLAKLLLEKAPQVVAFLCASGCRKAQYLARLALVESRKPRAARQQHGFYAPIAGAMLNLVIVTTGDEYAYIYARMPVSNAPQGWYERAVEEGWTVNVVRNAGTLYYEVPQDSLFEHASEDPELWEALYSFALAKAQAKPAAKKLVEKLLRIKPARAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK8</accession>
    <name>A1RZK8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752903.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1240"/>
    <dbReference type="EnsemblBacteria" id="ABL78638">
        <property type="protein sequence ID" value="ABL78638"/>
        <property type="gene ID" value="Tpen_1240"/>
    </dbReference>
    <dbReference type="GeneID" id="4601172"/>
    <dbReference type="KEGG" id="tpe:Tpen_1240"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_2"/>
    <dbReference type="OMA" id="MSDVFHL"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="43"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="290" mass="31115" checksum="7F3222B4685A6A05" modified="2007-02-06" version="1">MPGPRRTGGLAVTGEKVRAREPSGSGGLQYHIKCRPGDVAPTVLLPGDPERVPYISSFWDEYREVARHREYVTHTGRYKGVEVSATSTGIGGPAAAIAVEELLRVGASTFIRVGTTGAIQPFIDVGDVIIVAGAVRLDGTTKQYVRAEYPAIAHFEVVEALIEAAESVGARYHVGVVASTDSFYTGQARPGFKGYEQSWMKDLIPDLQRAGVLSFEMEASTILTLSSIYGARGGAVLAVVANRVKDELVENAGVEAAVRTANEAVKILHEWDEAKKAKGRRYATPGLFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL4</accession>
    <name>A1RZL4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752909.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1246"/>
    <dbReference type="EnsemblBacteria" id="ABL78644">
        <property type="protein sequence ID" value="ABL78644"/>
        <property type="gene ID" value="Tpen_1246"/>
    </dbReference>
    <dbReference type="GeneID" id="4600541"/>
    <dbReference type="KEGG" id="tpe:Tpen_1246"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_2"/>
    <dbReference type="OMA" id="FLMVNVM"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="352" mass="38485" checksum="B43BFE75EEB22B6A" modified="2007-02-06" version="1">MGLASYLVRRLATFLPSVLGALLITYLIAYVIPTDPVRAWVGEKLMDPSTLERLRKEYKFDAPWYEQFAFLVEKLLTGTLVDPTRGIPVVQQVAQRFPITVELAIFGMLFTVAIGIPLGILAAAKKDSFVDFFVRVFALFGSSMPAFVLYYFLILAFYVYVRASLLAGVPSLSPACAASLDSVRNAVPLLGYVVWAVGQVPMFGGLMCGDLGVVSATFVRMWLPGLALGLLSGGFIARIVRNSLLDALSSDAILFARARGLTSGRIWRHALKNAFAPIVTILGLNFAGLLTGAVIAETVFNIPGMGLYMYQGITRLNFPIIIAGTFIFSVIYIVMNLLVDLVYALIDPRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN1</accession>
    <name>A1RZN1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated protein, APE2256 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1263"/>
    <dbReference type="EnsemblBacteria" id="ABL78661">
        <property type="protein sequence ID" value="ABL78661"/>
        <property type="gene ID" value="Tpen_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1263"/>
    <dbReference type="eggNOG" id="arCOG01935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082641_0_0_2"/>
    <dbReference type="OMA" id="GGFKPEA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02619">
        <property type="entry name" value="TIGR02619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="253" mass="27522" checksum="4ADEBFF2EF64D6F2" modified="2007-02-06" version="1">MTVGTSILRNAASRASGDLAGRLRSWASARVGSREDAEAGERAAPGTPEFKFLYDVLALDPRGVSAELNAMWPYLEAGRVAAAYLLASDSGASTLCASVLKEYLGEHGVEVEVERVADLGRDFDKGLYNLLDALSRAVEGYRRRGYAVYVNATGGFKPETAVVYAAASLFGASRVYYIHETMGEVVELPTLPLALSPGYEDFARLLEEPLARRELEAKVRPEAIKDALARGILVEEGSQLRVRRWVRLLLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU9</accession>
    <name>A1RZU9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transport system involved in multi-copper enzyme maturation permease component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752994.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1332"/>
    <dbReference type="EnsemblBacteria" id="ABL78729">
        <property type="protein sequence ID" value="ABL78729"/>
        <property type="gene ID" value="Tpen_1332"/>
    </dbReference>
    <dbReference type="GeneID" id="4601307"/>
    <dbReference type="KEGG" id="tpe:Tpen_1332"/>
    <dbReference type="eggNOG" id="arCOG02436">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068384_1_0_2"/>
    <dbReference type="OMA" id="AFIMFLR"/>
    <dbReference type="OrthoDB" id="68949at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="305" mass="33094" checksum="17406F995C5E94BF" modified="2007-02-06" version="1">MVSKVLVIARKEFADTVSSRRFWIVVAVFLLVFLFNTVSVYLSFRAGQIPQERDLFLEIGRGIVASLEVAAPLLGIALGFSAISGERERGTLRLILSKPVYRDVVVSGKVLASLACITLVVSGASLLAVLASAIQGVAVMPDHIVRLAIFIALATLYALTYYAFSLLASILSRKSSHSLLLSLAVWVFFAIALPAASIAIASLLAEPPPPTTTGLAEWLSRVIQTSLTLQYFSPNLHYASLGYQLFGIRITFTAKGNVVEVTEYIGKIDPVRLVVTQWADLALLALYSLMAILASYIAFVNRQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV5</accession>
    <name>A1RZV5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein DxTHG motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753000.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78735">
        <property type="protein sequence ID" value="ABL78735"/>
        <property type="gene ID" value="Tpen_1338"/>
    </dbReference>
    <dbReference type="GeneID" id="4601313"/>
    <dbReference type="KEGG" id="tpe:Tpen_1338"/>
    <dbReference type="eggNOG" id="arCOG03435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508672_0_0_2"/>
    <dbReference type="OMA" id="LERNITC"/>
    <dbReference type="OrthoDB" id="124270at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027419">
        <property type="entry name" value="CRISPR-assoc_Csx1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013383">
        <property type="entry name" value="CRISPR-assoc_prot_DxTHG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019016">
        <property type="entry name" value="Csx1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09455">
        <property type="entry name" value="Cas_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02549">
        <property type="entry name" value="CRISPR_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="535" mass="58503" checksum="CDB33A9A003BB22C" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX4</accession>
    <name>A1RZX4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1357"/>
    <dbReference type="EnsemblBacteria" id="ABL78754">
        <property type="protein sequence ID" value="ABL78754"/>
        <property type="gene ID" value="Tpen_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1357"/>
    <dbReference type="HOGENOM" id="CLU_1575029_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="169" mass="19094" checksum="42EFD9F2DFED51D1" modified="2007-02-06" version="1">MCIKLQHRDKRSYTRAKDILTPTSRLSCMAQQTSVKGLVERVLSPGSEDRAFLDQFVRYLAAYKVVEQNLSLFDRLARCRSVEEFASVLYECVRVKDRVLSRLEEGVRRGEYRLAFDAKAEDVGRVFNVGSEAVERVVRLAAENPRFVGSVLASLALSYGGIVEAERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY1</accession>
    <name>A1RZY1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms endoribonuclease Csm3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CRISPR type III A-associated RAMP protein Csm3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1364"/>
    <dbReference type="EnsemblBacteria" id="ABL78761">
        <property type="protein sequence ID" value="ABL78761"/>
        <property type="gene ID" value="Tpen_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1364"/>
    <dbReference type="eggNOG" id="arCOG02658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067743_0_0_2"/>
    <dbReference type="OMA" id="CPVDNVF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013412">
        <property type="entry name" value="CRISPR-assoc_RAMP_Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02582">
        <property type="entry name" value="cas7_TM1809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="331" mass="36645" checksum="0AA8F1BFF9D44C65" modified="2007-02-06" version="1">MSALQRELRGIVRLGLKMETVTGLLIRMPVHAQVYRIGGADLYPIVTKRKYSLGGAEVEVEVPLVPGSSLKGRMRGLLELSLGKRLYTSDERIWLHARILWGTRAHPMSTDELIRDISGRCEVDEVFGSPAVGFDQLVEMLARDLASKQGKEEPDDADYEEAGKVARSLALNLALTRLLVDDMTPDKDYVGVLSENGRRILAISDFLEEKGENRIDRITSAADPRQVARVKPGVVFQGALRLLVFDIDKGYVKRNLELVAKGLRLVEETYLGASGSRGYGRVKFKDISVEVMKTFGAEKPEYRKLADLASVEALLGKVDEIAGEVEKTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S004</accession>
    <name>A1S004_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753049.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1387"/>
    <dbReference type="ESTHER" id="thepd-a1s004">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78784">
        <property type="protein sequence ID" value="ABL78784"/>
        <property type="gene ID" value="Tpen_1387"/>
    </dbReference>
    <dbReference type="GeneID" id="4600670"/>
    <dbReference type="KEGG" id="tpe:Tpen_1387"/>
    <dbReference type="eggNOG" id="arCOG01650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_2"/>
    <dbReference type="OMA" id="FHGFSDH"/>
    <dbReference type="OrthoDB" id="69240at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="275" mass="29959" checksum="234416761907A5DE" modified="2007-02-06" version="1">MSAVTREVNLPSGLSTVMRAWLPEGEPKAVVVGIHGFAEHSGRYAHVGDFLSSRGYALYMYDLRGHGLSKWERGYVDSFDQFVEDSVAFYRLVVSGHAGKKGFVLGHSMGGVIAVLTVYRLGGEVSGLVTSGAALEVNVGAGTRLLLRLLSAVNPRGRAKLPVNVDCLSRDKAVAESYVADNLVFKDPTYRLLAEFGRGVSEAWKAAAKVTVPALLMHGEEDCLVPPSASRKLFQVLPSSDKTLEVFPGMKHEIFNEVDKEKVLEKLAEWLDKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S011</accession>
    <name>A1S011_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1394"/>
    <dbReference type="EnsemblBacteria" id="ABL78791">
        <property type="protein sequence ID" value="ABL78791"/>
        <property type="gene ID" value="Tpen_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1394"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_1_0_2"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="123"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="559" mass="62096" checksum="5B8CDC707216CC2D" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S020</accession>
    <name>A1S020_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_1403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753065.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1403"/>
    <dbReference type="EnsemblBacteria" id="ABL78800">
        <property type="protein sequence ID" value="ABL78800"/>
        <property type="gene ID" value="Tpen_1403"/>
    </dbReference>
    <dbReference type="GeneID" id="4601817"/>
    <dbReference type="KEGG" id="tpe:Tpen_1403"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OMA" id="MGSNMIT"/>
    <dbReference type="OrthoDB" id="45576at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="296"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="393" mass="41269" checksum="BB2E59C6745DF89C" modified="2007-02-06" version="1">MNLSDYLYLAFTSLKEKKGRAAGAALGVMIAVLALSLALGVGESFQKAFVEQLQSTIAADSVFVIGGYAGLTDADIAYFKSIPGVKDAQGVLMASGVVYTESGEKPVNIVAVDPSFLPRYLGVSDMRKAVAEGETEPRGLGVLVSYSLWRDQETGRKLLDVGSVLNVRVGGRNVQVFVVGLLEQTSSSMSMGHDFQVATIYMDPDAFFTYLGRTRNYPVAIVLVENLDALDSITENIRALAPPGSRIISAAAMVKQFTSLVGALQLFIALISAVGMGVTALWIFDSTTISVTQRTKEIGILKALGYTSGDILAVFLLETVIVSLVGAAAGLLAALASSSVVKISAFGIQIGVALTPHTAGLAVLLPLAANVLAAFIPARRGASLNPVEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S047</accession>
    <name>A1S047_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1430"/>
    <dbReference type="EnsemblBacteria" id="ABL78827">
        <property type="protein sequence ID" value="ABL78827"/>
        <property type="gene ID" value="Tpen_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1430"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="16977" checksum="93F669BD251059EB" modified="2007-02-06" version="1">MVSGVVSVGEQAPDFEAESTGGVFRLSSLRGRRVVLFFFPKAFTPGCSRELSEFSELYEEFKRLGAEVVGVSADKVNTLRKFAKRYNAAFNLVSDPSLEVAGKYGVVGRSGKTAERVTFVIDEQGVVRAVLRDLPRAEDHPHAALEALKSLAGQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S062</accession>
    <name>A1S062_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753107.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1445"/>
    <dbReference type="EnsemblBacteria" id="ABL78842">
        <property type="protein sequence ID" value="ABL78842"/>
        <property type="gene ID" value="Tpen_1445"/>
    </dbReference>
    <dbReference type="GeneID" id="4601154"/>
    <dbReference type="KEGG" id="tpe:Tpen_1445"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_6_2"/>
    <dbReference type="OMA" id="TGYAIGD"/>
    <dbReference type="OrthoDB" id="66517at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="31149" checksum="0E0C628688D2C2D0" modified="2007-02-06" version="1">MRDRLRVGVAQIHSLLGDVRRNLEKHLEYVERARELGVEVLAFPELSLTGYLLRDLAYEVSDAAREALGEIAEASRGLCVLVGLVHEPRAGIYENSVAVVRDGSVAGVVSKLYLPDYGLFEESRYFREGSCSREGVFECGGWRVAPIICEDAWHPEPAELAARRGADVVFIHASSPIRGLYGSGEANIERVWEAIAVTRAVENACYVVFANRVGPEDEEYFWGGSMVVAPDGEVVARAKKMEEELLVADLDLYRLRASRRFSSFKRHRRDIHVVLGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S070</accession>
    <name>A1S070_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maltodextrin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753115.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1453"/>
    <dbReference type="EnsemblBacteria" id="ABL78850">
        <property type="protein sequence ID" value="ABL78850"/>
        <property type="gene ID" value="Tpen_1453"/>
    </dbReference>
    <dbReference type="GeneID" id="4600579"/>
    <dbReference type="KEGG" id="tpe:Tpen_1453"/>
    <dbReference type="eggNOG" id="arCOG00154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_1_2"/>
    <dbReference type="OMA" id="WAHDWIG"/>
    <dbReference type="OrthoDB" id="74127at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="415" mass="45587" checksum="5F67549428804168" modified="2007-02-06" version="1">MTEKQQKQASKKTLTIVAAVVLVLVVLGVAAMLLTQKPSAPKRNVTIVIWHAMGPEEVKTLEDVIADFHVQHPEITVKLEQKADLETSLKTAIPAGQGPDLFIWAHDWIGKFAEAGLLEPIDEYVTPSVLNKFSPIGQNAIEYRGHYYAMPLAAETVALIYNKALVPNPPKTFDEMKSIMAKFTNPDKGTYGLATPIDPYFLSGWVHAFGGYYFDDKTKQPGLDKPETIKGFKFFFEQVYPYVAKTRDYNAQVSLFLEGKAPMMINGPWSIGDVKKAGINFGVAPLPPIDSSSVPHPYGGVKLVYVAKGVKDKAAVWTFLEWLTTNPNVIKQFAIRNGYIPVLKEVLNDPEIQNNPVIYGFGQAVQNAIPMPKSPEMAAVWGPVDTAITNIMGGKQSIEAALTAAQQEVLSALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S096</accession>
    <name>A1S096_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium-transporting ATPase</fullName>
            <ecNumber evidence="10">3.6.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_1479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.12" evidence="10"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753141.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1479"/>
    <dbReference type="EnsemblBacteria" id="ABL78876">
        <property type="protein sequence ID" value="ABL78876"/>
        <property type="gene ID" value="Tpen_1479"/>
    </dbReference>
    <dbReference type="GeneID" id="4601580"/>
    <dbReference type="KEGG" id="tpe:Tpen_1479"/>
    <dbReference type="eggNOG" id="arCOG04804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_2"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="12407at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="517" mass="53937" checksum="C6C7F8E0812F0735" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C5</accession>
    <name>A1S0C5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753170.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1508"/>
    <dbReference type="EnsemblBacteria" id="ABL78905">
        <property type="protein sequence ID" value="ABL78905"/>
        <property type="gene ID" value="Tpen_1508"/>
    </dbReference>
    <dbReference type="GeneID" id="4601209"/>
    <dbReference type="KEGG" id="tpe:Tpen_1508"/>
    <dbReference type="eggNOG" id="arCOG04429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_4_1_2"/>
    <dbReference type="OrthoDB" id="124075at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06067">
        <property type="entry name" value="H2MP_MemB-H2evol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004420">
        <property type="entry name" value="Pept_A31_hyd_mat_HycI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="163" mass="17616" checksum="719FC399574E9873" modified="2007-02-06" version="1">MATLPEVLKSAVEEILRRRPALVFLGNYLRGDDAAGLLVGARVKASAEYPYVFVCEEGLENCLHELRRAGVKVALIVDAVDAGLEPGSIVLSRLDAAYEALPSTHKLPLRLVAEYLGLEEVYVLGIQVQNLEVSQGVSRPVAESARRLAEALLEALGRLGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E0</accession>
    <name>A1S0E0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753185.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1524"/>
    <dbReference type="EnsemblBacteria" id="ABL78920">
        <property type="protein sequence ID" value="ABL78920"/>
        <property type="gene ID" value="Tpen_1524"/>
    </dbReference>
    <dbReference type="GeneID" id="4600661"/>
    <dbReference type="KEGG" id="tpe:Tpen_1524"/>
    <dbReference type="eggNOG" id="arCOG05548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375586_0_0_2"/>
    <dbReference type="OMA" id="MAKRRNY"/>
    <dbReference type="OrthoDB" id="116896at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="189" mass="19586" checksum="721AD649A202C587" modified="2007-02-06" version="1">MQVKKTTLVALLIALASTAFAVAAVTLTNITEWHIQAAGTPPIVKVAGADAGTGLISVSTTTASDGTNRTVITIKGYTGDPTRYSEVIKICNKDTTKTYTVSLVYKGVISSGGWNNYVKYLTLWLGGYPSGPSITITSTTTPPASTGTVQVGPGICVPVSAEVLVDASTPQSSWNTDLMSIQIDVVSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E1</accession>
    <name>A1S0E1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1525"/>
    <dbReference type="EnsemblBacteria" id="ABL78921">
        <property type="protein sequence ID" value="ABL78921"/>
        <property type="gene ID" value="Tpen_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1525"/>
    <dbReference type="eggNOG" id="arCOG14692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609202_0_0_2"/>
    <dbReference type="OrthoDB" id="74908at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="469" mass="50675" checksum="9BFA745ECD60567F" modified="2007-02-06" version="1">MVVRLRKRDVYLYLASLLVAAFATLVLLYPLGVQAVVVGGARDVEAKPAELDVYASNTTVYCYGGALELKNLGAAGQAYRLRISASPPRGLSLLELRLNGSAVFALGAVNASREVVLPAGSSARLDLCVKASSPGSVELVFVDPAYARATESRVRVSYRLTDWWNNTFPRRVELVPVVSKPGVALFEVTGSGEVYVNGRLVRRISGIAGLGSDAFAVVLRRSGADYLLPYQVEAWTVRGDGVAEPSGVRRPGEAVWGDDRLVFAAYLENGSRIYIYMGGRYPWGEAGDVQVLEGAALLGGERLNLSRWGVEARGFSLNLSGYVVFPYQSVKEELSDPGSWRNAASGPVRTVLWFSTTGFSNYRVEAAVTLWGRGVNAALVYVWPSLSYRGIVLEWVSPRIALRGNTSLAFNPGTTGNYLPLRLEKYGVALCRDFFLSGGTYGYFSLALGPAPFAELKRLDAAYSSFPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E3</accession>
    <name>A1S0E3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753188.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1527"/>
    <dbReference type="EnsemblBacteria" id="ABL78923">
        <property type="protein sequence ID" value="ABL78923"/>
        <property type="gene ID" value="Tpen_1527"/>
    </dbReference>
    <dbReference type="GeneID" id="4600664"/>
    <dbReference type="KEGG" id="tpe:Tpen_1527"/>
    <dbReference type="eggNOG" id="arCOG07037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2662568_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="7821" checksum="4A942C1C001DA37C" modified="2007-02-06" version="1">MSGGSYYAVCGAATAPLYTGSAYWVDLRLLSGVYEAIVRGSDGSILSRYSCAPPGSPSYVGFENVGSFTLNVWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E5</accession>
    <name>A1S0E5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1529"/>
    <dbReference type="EnsemblBacteria" id="ABL78925">
        <property type="protein sequence ID" value="ABL78925"/>
        <property type="gene ID" value="Tpen_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1529"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699466_0_0_2"/>
    <dbReference type="OMA" id="FIPRIIA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="394" mass="42005" checksum="035B6C71F9E5CC8E" modified="2007-02-06" version="1">MSRKAETQSGERAEPRASTGGGRAEKVLVAYGLASSFAGNLVSPFMALYLYGLAGGRFFQAGIASQAPVAVSVIMGLFWARLSDTNGSRKKFVQLSLATGSLASLALSFASSINDAILVQILGAFTGSAGGAAFSALMAEVFKDKRGSRLGVYNASTVIGGFAGSMLSGFLYNWIGFRWMLRLNALLGVLPLVLISMIPEEGNRNPVSSRKLVSIPKIPRRFWKLYLARLVLSLPGALSGGVFSVYFVKYLNGPPEAWSTLVAVTTLFGLASIPYGRLADRLSTREMFVLAGLGWTALYLGYFLSPNYLVFSLFFVIPVWPAFWLAYSKALMDLSDESERATFYAFEGTLSALFGSAVGVAAGLVADLYSPRTLFLLSSASALLGAAVAGVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G9</accession>
    <name>A1S0G9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spermidine/putrescine ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_1553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753214.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1553"/>
    <dbReference type="EnsemblBacteria" id="ABL78949">
        <property type="protein sequence ID" value="ABL78949"/>
        <property type="gene ID" value="Tpen_1553"/>
    </dbReference>
    <dbReference type="GeneID" id="4600902"/>
    <dbReference type="KEGG" id="tpe:Tpen_1553"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="362" mass="40714" checksum="C5F40970C7CA2DD9" modified="2007-02-06" version="1">MPYLSAENLVKRYGKVLAVDHVSFSVERGEMLGLLGPSGCGKTTTLRIIAGLTVPDEGRVLVEGEDITNAPPEKRGMGMVFQNYALWPHMTVYDNVAFPLRARGMPADEVQRRVKEALEIVRLYELKDRYPHQLSGGQQQRVALARALAVQPRVILLDEPLSNLDAKLREEMRFELKELQRKLGVTAVYVTHDQAEALALSDRIAVMKDGRIVQIGTPREIYEEPANAFVADFIGKINFLEGRIEEFLGEGYVLVRVGDGLYVKAYTKRVHEKAPVIVGVRPGYIELRGTRPEKVDESRVNVFEGVVVRKTYLGDVYDYRVRVSEGVTLRVEARENYDVGSKLYLVVPADRTLVIDKKTGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J7</accession>
    <name>A1S0J7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1582"/>
    <dbReference type="EnsemblBacteria" id="ABL78977">
        <property type="protein sequence ID" value="ABL78977"/>
        <property type="gene ID" value="Tpen_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1582"/>
    <dbReference type="eggNOG" id="arCOG05120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080107_0_0_2"/>
    <dbReference type="OMA" id="YVILYPH"/>
    <dbReference type="OrthoDB" id="90759at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016771">
        <property type="entry name" value="Fe-S_OxRdtase_rSAM_TM0948_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020275">
        <property type="entry name" value="RadSAM_TM0948_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="32"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="256" mass="29362" checksum="FD69CD8E48CCF57C" modified="2007-02-06" version="1">MSGERGYDPILLAEAVRRMVARGSERRYYRFRGGRWYGGIATADCVGCNLRCVFCWGWRVRDRPSGAGRFYSPEEVYERLASIAGRRGYRLVRISGNEPTIAWDHLLRVIELLEADGRFRFVLETNGILIGADKSKARDLSKFSSVHVRVSLKGASEEEFHLLTGARREFYRLQLEALRNLLDEGVPAHPAVMLSFSEPRAVDELKARLAEIDRSLVEEFEEEYVFLYPHVVEQLRRAGLQPRVAFEPDNIPEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L9</accession>
    <name>A1S0L9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB domain protein nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753264.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1604"/>
    <dbReference type="EnsemblBacteria" id="ABL78999">
        <property type="protein sequence ID" value="ABL78999"/>
        <property type="gene ID" value="Tpen_1604"/>
    </dbReference>
    <dbReference type="GeneID" id="4601535"/>
    <dbReference type="KEGG" id="tpe:Tpen_1604"/>
    <dbReference type="eggNOG" id="arCOG01875">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134838_0_0_2"/>
    <dbReference type="OMA" id="PCVLLDY"/>
    <dbReference type="OrthoDB" id="76894at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="168" mass="19092" checksum="D1B9E30DD91476EC" modified="2007-02-06" version="1">MTVGFRGETVFPECCRHLFRSPELSGVINLERDFLCCAEDYPVALVPIGLLRPHEEVDPSRLRSLEEEILGAGYLERPVLVECETLIILDGHHRVAVLRKLGKTVVPALLVSYEDPCVSVDSWRSDWVVTKDLVIRAGFTGKLLPHKTSRHRLCFEVPEVRYPLSMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M6</accession>
    <name>A1S0M6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1611"/>
    <dbReference type="EnsemblBacteria" id="ABL79006">
        <property type="protein sequence ID" value="ABL79006"/>
        <property type="gene ID" value="Tpen_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1611"/>
    <dbReference type="eggNOG" id="arCOG06060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="PRDTYFC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="277"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="522"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="588" mass="64859" checksum="C33807D4114BA607" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N0</accession>
    <name>A1S0N0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase formation HypD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753275.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1615"/>
    <dbReference type="EnsemblBacteria" id="ABL79010">
        <property type="protein sequence ID" value="ABL79010"/>
        <property type="gene ID" value="Tpen_1615"/>
    </dbReference>
    <dbReference type="GeneID" id="4601907"/>
    <dbReference type="KEGG" id="tpe:Tpen_1615"/>
    <dbReference type="eggNOG" id="arCOG04428">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_2"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="OrthoDB" id="24633at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="411" mass="44811" checksum="59FA5B1B440143EB" modified="2007-02-06" version="1">MEGQGLAFLEKLGYLEKAFRSNARLAGALRGYIARKFEEIRAREGRDYRIKIMDFCGTHEWTIVHFGLRSLMPEGVELVAGPGCPVCVTPSWYIERAIELSLSGVTVYTYGDTFKLRAVNPVDGVSSLEEARAAGGRVRLVVSLVDAVRDASRHGGESVFLGIGFETVAPGYARAVVSGSLPENLKLMSLVKLTPPAMFYSLDILRDKPTEPPVMGVIAPGHVSTVTGAKAWEPVAEQFQVPVVVSGFEPIDVLMGIAEIMRQLARGEYGVKVEYTRAVTWEGDLEAQAAIHEAFEAVDDAWRGIGFLPLSGLRLREKYGRLDALRHFGIEELTPEKWRKDTPPGCRCAEVTLGKAKPTDCPMFMKKCTPEKPYGPCMVSLEGTCAVWARFGGGGLADQIARDLALEAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P9</accession>
    <name>A1S0P9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753294.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1634"/>
    <dbReference type="EnsemblBacteria" id="ABL79029">
        <property type="protein sequence ID" value="ABL79029"/>
        <property type="gene ID" value="Tpen_1634"/>
    </dbReference>
    <dbReference type="GeneID" id="4600913"/>
    <dbReference type="KEGG" id="tpe:Tpen_1634"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="CHFPEDP"/>
    <dbReference type="OrthoDB" id="41087at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="334" mass="36621" checksum="ECE3831E57A4C12C" modified="2007-02-06" version="1">MSHATTRELLVVEDLRVYFPVRRTLGEILRGRQRLLRAVDGVSFSLRSGEIMALVGESGSGKTTVARAVVGLVKPTSGRILFDGRDISRLDGRELRSYRRSVQMVFQDPSVSLNPRMKVGEQVKYPLDVNKVGSEDERREAALKALERVGLVPPEDFYSRYPHQLSGGQRQRVAIARALVLNPRLLLADEPISNVDVSARAQILALLKSLRDERSLSILYITHDLSSAWAIADSVAVMYLGKLVEAGPVQEVFSNPLHPYTKALLSAVPSLTPGGAARRRVTLKGEIPSPLNPPAGCRLHPRCPFATEKCRAEEPALAEAGKGHLVACHLYATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Q7</accession>
    <name>A1S0Q7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1642"/>
    <dbReference type="EnsemblBacteria" id="ABL79037">
        <property type="protein sequence ID" value="ABL79037"/>
        <property type="gene ID" value="Tpen_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1642"/>
    <dbReference type="eggNOG" id="arCOG01997">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_2_1_2"/>
    <dbReference type="OMA" id="IRMIFPQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="203" mass="21471" checksum="09103BA0BCCD9DAD" modified="2007-02-06" version="1">MSVALADTLFKSLFVAVQLYAVLNPVSVIPTFVNLTEGLDSREKVHAVRKASMIVFSLMVVFSLIGDPLLRLLNVSIASLRLGGGVLLMVIAVDMLSGMSRTKGLESGDEALVVPIATPLLVGPGTITTLIVLSASEGLPVTLLGALLATLLVYATLAFGESLLELLGRNFVRSLGRFMAIIIAGISAEMIHRALLEWGIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T5</accession>
    <name>A1S0T5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753330.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1670"/>
    <dbReference type="EnsemblBacteria" id="ABL79065">
        <property type="protein sequence ID" value="ABL79065"/>
        <property type="gene ID" value="Tpen_1670"/>
    </dbReference>
    <dbReference type="GeneID" id="4600922"/>
    <dbReference type="KEGG" id="tpe:Tpen_1670"/>
    <dbReference type="eggNOG" id="arCOG01618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="HVDREGT"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="35964" checksum="E4814B580A2ED240" modified="2007-02-06" version="1">MEYTVLGKTGEKVSRIGLGAWEFSEAWGLTDYEKAKSVVKRALELGINFFDTAMVYGNGFSEKTLGSALRELGAKRDEIIVSTKIPGEFLNPLDIPRAVEHSVKLLGLGYVDVLLAHWPPCWHNYPTKVYARAMEQLVNVGLVRYLGLSNFPVELVESFRSSLARADVEVFQHRYNLVERWAEAEVIPYAEKHRITVQAWSPIAKGALTGKYTPDNLPQFADVRAREPVFHPENFEKVWRVVQLLKSTGEKYGKTPVQVALNWLITSSPAVVPIPGAKSPAQVEELAGAAGWRLKPEDWAALEEASRGLTISYSVYYVKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U1</accession>
    <name>A1S0U1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753336.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1676"/>
    <dbReference type="EnsemblBacteria" id="ABL79071">
        <property type="protein sequence ID" value="ABL79071"/>
        <property type="gene ID" value="Tpen_1676"/>
    </dbReference>
    <dbReference type="GeneID" id="4600928"/>
    <dbReference type="KEGG" id="tpe:Tpen_1676"/>
    <dbReference type="eggNOG" id="arCOG01534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_2"/>
    <dbReference type="OMA" id="FTGWWNE"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="77"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="636" mass="71833" checksum="3859A9D60A71A6C9" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y8</accession>
    <name>A1S0Y8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753383.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1723"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79118">
        <property type="protein sequence ID" value="ABL79118"/>
        <property type="gene ID" value="Tpen_1723"/>
    </dbReference>
    <dbReference type="GeneID" id="4601748"/>
    <dbReference type="KEGG" id="tpe:Tpen_1723"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_2"/>
    <dbReference type="OMA" id="KPHIDIH"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="380" mass="42805" checksum="6E081C3652E3C804" modified="2007-02-06" version="1">MKILYVNPANIDYPGGGERFAVEVLTRLSKRGHEVGVLHINWAPHPATSAGNESKLLDRGAELHKCGYIKLPRGFPVVDPRCLVKPSKQYDVLYIPAYSPNELTVSLLKKSKALSVPAVAVFHCMLADNVLARLYTPLYIAAFNSFDKLHVLNRFQRNFLKSHGIPEEKIEFIPNGVDTSTFQLCRDPSASEDFNIVFVGRLLKDKGVDTLLRIIYLINDELNLHDVKFTIVGSGPLEEDIKKLAQKYQNVVFLGYVKHENMPSIYREANLFLLPSRSEGMPLSLLEAQACGLPAVASKIPGVLDIVRDGVTGRLVDAEDVRGFVSAIEECYRLWESSPQEYYNLNKKIREYIVRNYDLEVVVGKIEKMLHEAIYKVQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z5</accession>
    <name>A1S0Z5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753390.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1730"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79125">
        <property type="protein sequence ID" value="ABL79125"/>
        <property type="gene ID" value="Tpen_1730"/>
    </dbReference>
    <dbReference type="GeneID" id="4601755"/>
    <dbReference type="KEGG" id="tpe:Tpen_1730"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670180_0_0_2"/>
    <dbReference type="OMA" id="WYSLRNC"/>
    <dbReference type="OrthoDB" id="65802at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="420" mass="45803" checksum="B58DE9E4C2C4DCED" modified="2007-02-06" version="1">MTSEPSALLGAVAPPGLLPEAFYLLLDALSLLTLAGILAWSAYHAPIIVAGLLAPRGSGDDPGNGLPRVTVIVPSKDEGRRVERCLNAILSSDYPLEKLEVIVVDASSDGYVEEIVRRAGERYPGAVRLIREEEPRGKPAALNRALREATGEVVAVFDADSVPERDAIRRAVKHLEEPGVAAVQGKTLVLNERESVLARVASKEEKAWFHALIRGRERLGLFVPLTGSCQFVKRSALEEVGGWREDALAEDLELSMDLLARGYRVKYANDVVSWQEAPTSLRSLAVQRNRWYRGYMEAFARHLRLALAGRRGLDAAILSAGPYLMALSLLAVAAWLASTALPHVNHFSTPAALVAALNAVSLFSVSVALALSERPVSAKNLAWVPVIYAYWFTLSAVALHALAEIILRRPRVWRRTPKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S102</accession>
    <name>A1S102_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1737"/>
    <dbReference type="EnsemblBacteria" id="ABL79132">
        <property type="protein sequence ID" value="ABL79132"/>
        <property type="gene ID" value="Tpen_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1737"/>
    <dbReference type="eggNOG" id="arCOG03876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084123_0_0_2"/>
    <dbReference type="OMA" id="HEYGEYP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="29356" checksum="E2C920AC166CA0C9" modified="2007-02-06" version="1">MAYWLGRKFEKINARLDRVEERLGGVEKRLEGVEGRLDKVEERLESVEENLGGVQERLTKAERRLADLEGRLSKVEGRLEALERRVDGVEKALGDVGERLDAVEARLSRVEGRLEGAESRLAGVEHGLEKVESRLSRVVKGFESHQEFLIDYLASEGVIKEKTALVVRAELRSVLSLLSNPLTKEEVEKLREYLEKDPGEFTMEEAEDFLRLARKAVEEHGDKYEVYKLHLYAALVRGWTRRRLAKAEEKGGNRCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>A1S107</accession>
    <name>A1S107_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753402.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1742"/>
    <dbReference type="EnsemblBacteria" id="ABL79137">
        <property type="protein sequence ID" value="ABL79137"/>
        <property type="gene ID" value="Tpen_1742"/>
    </dbReference>
    <dbReference type="GeneID" id="4601767"/>
    <dbReference type="KEGG" id="tpe:Tpen_1742"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="DIVPLYC"/>
    <dbReference type="OrthoDB" id="92866at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="239" mass="25938" checksum="59DF861774CAA8F8" modified="2007-02-06" version="1">MLECRDLWAGYPGFGDVLRGVTLGLERGEVVALLGPNGSGKTTLLLALAGLLKPSRGSVLLDGRDLWSQLPGARRRIGLVFQDPDDQLFNPTVEEELAFALNQLGLPEAEKASRLERAARMLGVEGLLDRPVHALSYGEKRRVALASVLVYDPEYLLLDEPTANLDPRSASALLEAVCRLKREGRGVLLATQDVGVASRVADRYAVIHGGRIAWEGAELPREVLEKHGLTVADVSCREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S110</accession>
    <name>A1S110_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753405.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1745"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79140">
        <property type="protein sequence ID" value="ABL79140"/>
        <property type="gene ID" value="Tpen_1745"/>
    </dbReference>
    <dbReference type="GeneID" id="4601770"/>
    <dbReference type="KEGG" id="tpe:Tpen_1745"/>
    <dbReference type="eggNOG" id="arCOG01385">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779921_0_0_2"/>
    <dbReference type="OMA" id="LGKNSEW"/>
    <dbReference type="OrthoDB" id="74894at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="39411" checksum="CE3B4890E16B6664" modified="2007-02-06" version="1">MARAGEYPLITVAMVALNREWIIGHALKSLLSQTYPHDRIFFVLVDGGSVDRTVEVVREALSGSDLAGFEVVVQRSNIPEARNIAIERMRGEAIFFWDSDVLLEPDGLKMLYEAASDYGIDILSADTLSIKVSSVEEGWRVLEELCKKRGKIGVELVPAVAMGATLIRKIVLDRVRFDPELTFGEDADFCVKARSLGYRVAVHRGVVAVDVNVTGRAGSDIYVSKPLTELLKGIRKKAKVKVLGLSFDPGLKDVLVYMWRYKRYLYYLGYLPMLVALIVGLAKNLPMLTLLFPAYVLPYLLYQAKRRGILLGLKTFIASLVVGLPLSLSMLAYATARSLERFVSTPRRKKHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1S121</accession>
    <name>A1S121_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753416.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1756"/>
    <dbReference type="EnsemblBacteria" id="ABL79151">
        <property type="protein sequence ID" value="ABL79151"/>
        <property type="gene ID" value="Tpen_1756"/>
    </dbReference>
    <dbReference type="GeneID" id="4601954"/>
    <dbReference type="KEGG" id="tpe:Tpen_1756"/>
    <dbReference type="HOGENOM" id="CLU_965123_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="288" mass="30454" checksum="4815CF41F3D5FA59" modified="2007-02-06" version="1">MSRRSLAELLVLQLLLVALLALFFYKPGGTAAGTPDLREVPRLFVEAVYHLNSSSTMLRNPARWNADFRSMSANASRIAGEIASYRNALSEMDPSDLVLRLLSASDSYGRMANASSSIYAALDVLSGSKESIQRYLAALEECNAAEAHRLGLSIAGNLSRAYSLVGLAAGNLSLADPSTLLSQSHVDAHRNASEAVDAAQRYLKQLLLAVDITSKHPEELDALCKARKAGRSIAVSEQLARSLGALNPPDAGPFSYAVSRLKSLLYAVANAQQGGGSGAGYGAPSSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S127</accession>
    <name>A1S127_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753422.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1762"/>
    <dbReference type="EnsemblBacteria" id="ABL79157">
        <property type="protein sequence ID" value="ABL79157"/>
        <property type="gene ID" value="Tpen_1762"/>
    </dbReference>
    <dbReference type="GeneID" id="4601960"/>
    <dbReference type="KEGG" id="tpe:Tpen_1762"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_2"/>
    <dbReference type="OMA" id="PAITHQT"/>
    <dbReference type="OrthoDB" id="14047at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="319"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="451" mass="51097" checksum="F9D591E3CA410794" modified="2007-02-06" version="1">MLKLEWSAGTILLRGSPPPSVAPYFRFDPRVKGYRALAIQYRWIVEALREAGVEFEDDVLHPPQCKLQAREVQLRDYQEEALERWMAGRRGVVVLPTGAGKTMVALAAIARLACPTLIVVPTLELMDQWEEGVRRHLGVAPGRYGGGEKEVGCVTVATYDSAYVNAEFLGDKFELLVFDEVHHLPSPGYRQVAELSAAPWRMGLTATPEREDGLHELLPYLVGPVVYRRGVGEMAGKWLAEFDVVRVYAEMSPEEREEYERLTRTYRSFLRKRGLRIRGPRDFERLAALSVKDPEAREALLAWYRARRIALHASSKMEVLEELLARHRGDKVLIFAEHGDVVRRISSRFLVPEITYRTPEEERRAVMSAFRKGLVRAIVTSKVLEEGVDVPDANVAVILSGTASRREFVQRLGRVLRPREGKRAVVYEVVTSGTKEVEISRKRRKALKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>A1S130</accession>
    <name>A1S130_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="5">GAPDH</shortName>
            <ecNumber evidence="5 7">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gap</name>
        <name evidence="9" type="ordered locus">Tpen_1765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5 7">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="5 7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753425.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1765"/>
    <dbReference type="EnsemblBacteria" id="ABL79160">
        <property type="protein sequence ID" value="ABL79160"/>
        <property type="gene ID" value="Tpen_1765"/>
    </dbReference>
    <dbReference type="GeneID" id="4601942"/>
    <dbReference type="KEGG" id="tpe:Tpen_1765"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OMA" id="NAIVPNP"/>
    <dbReference type="OrthoDB" id="32079at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL79160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="38349" checksum="9A72DB6432C8540A" modified="2007-02-06" version="1">MLVPIRVLVNGIGTIGKRVAHAVSLQPDMVLVGVSSPRPSLGVLSSLSRGGVLEGVPFYVRGASPSLFEERGVRVGGVLEDLLGSGRVDVVVDAAPGGEGLRNRDELYSRYGVRAVFQGGEPAAVAELTFSPFFNYGDAFGRRYVRVPSCNTTGILRVVSALSSLGELREVFVVIARRAADPADRKGARLNALSLDGGVPSHHASDVRTVLPWLNVFTVAVKVPTTLAHLHVARVRLGGRLSRGDVIEALESHRRIVVAGGEFEATPDLLEFFRDRRLRGDMYEVAVLEDSVHVDGEYATLSYVVHQEAVVIPENIDAVRAMFLGGDPEAGMEATDSSLGVTRGRLAPRRALVAARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S193</accession>
    <name>A1S193_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753488.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1828"/>
    <dbReference type="EnsemblBacteria" id="ABL79223">
        <property type="protein sequence ID" value="ABL79223"/>
        <property type="gene ID" value="Tpen_1828"/>
    </dbReference>
    <dbReference type="GeneID" id="4602065"/>
    <dbReference type="KEGG" id="tpe:Tpen_1828"/>
    <dbReference type="eggNOG" id="arCOG07491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619146_0_0_2"/>
    <dbReference type="OMA" id="LLNIAWI"/>
    <dbReference type="OrthoDB" id="80624at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="442" mass="47347" checksum="AE002C28BCF10CD4" modified="2007-02-06" version="1">MSNTEKALARVLLVLEALLGGFYVAVTRGLFVPMMAYSGYSLENMALVFLPTSISGAALSWGLYKYPEEATRRFKVLSLATHIAERFVWLTLPFFLEKPIVVAFLYMLGNAVSAVVSIFLGSLIYSYFGDVGEVMKVSVWRSAAGTAASLLGAIYMTAVSAVLPAPQSYYVSYVTAFVVGLGSSVALLLVPAYPKQIVETGGRASEEVLIRGSQAFLVLTFMLAGSNLVGLSWAPLLKDMGAPLYVSLALSITGNIGGVIGSLVIKGYKAYVAGLVANTVLTAVIPFLPLPGMHVGLSFFTSLTFMAANLLAMQIFAEINSHMGRVRASAYMTAGNYLGLLVASLVALTLARSPFLGLLLAAALKLVATVLALVAIPETAIVPERKAYEFSRMIYSISLVGYVFTVQASREFVRTFIETLALVALLLLLYTIYRFEALFIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1S198</accession>
    <name>A1S198_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate-ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753493.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1833"/>
    <dbReference type="EnsemblBacteria" id="ABL79228">
        <property type="protein sequence ID" value="ABL79228"/>
        <property type="gene ID" value="Tpen_1833"/>
    </dbReference>
    <dbReference type="GeneID" id="4602070"/>
    <dbReference type="KEGG" id="tpe:Tpen_1833"/>
    <dbReference type="eggNOG" id="arCOG00409">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_2_2"/>
    <dbReference type="OMA" id="HSMILHK"/>
    <dbReference type="OrthoDB" id="80207at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="107"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="323" mass="37545" checksum="EEDDD3473FC51F5D" modified="2007-02-06" version="1">MEQKTLTLLRDYGVKPLHELSQEELEVKRSIARITTYTLSFLSRYLVERGFDWVLPVVFSKSTDPLWPDPDFSIEKRIEVEIYGETVRSTQSMIVHKQVLVSLLSPKIFVFSPNVRIETRKRASTGIHAYEFTQLDFEVRGASSSYIRSLVEDMLKSYVSSLKREMEHELSFLGSELPEIMTPFKVVDSKELEEEYGKEWQTSLRSTLKEPVWVVNIPREFYDFEDPETGRWDNYDLYVPRVGEILSGARREYEYEKILSKMKRDGVRPENYRVLLDLAREGRLLPSAGAGIGVERLLLWVTGVRHIGIVQPFPRIPGIVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C2</accession>
    <name>A1S1C2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1857"/>
    <dbReference type="EnsemblBacteria" id="ABL79252">
        <property type="protein sequence ID" value="ABL79252"/>
        <property type="gene ID" value="Tpen_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1857"/>
    <dbReference type="HOGENOM" id="CLU_680813_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="404" mass="43559" checksum="1CA394BE3CD88AE1" modified="2007-02-06" version="1">MVMYASNTVSTAALNKPLNRPLNTSKAMRMDKKKLLVVALLLAVVAGAVYLAHLDADKREVPSETIDTGKYIDAYVSVYVNGRLAATQRMHSFTSAFSYLAPIAFTPTSSFTQTSTFTGVVEPVSAYGAALTPGSYSWILQKGRFYGCPASAASPWQVAITQTPLPRLVAVFYNTSGSKIGEAVFSGTSVDLANKVVNATGTVLYLTASFTYTGATATNIKEVHLARPTGQVYSLAPGASCGGMRITNDSFATAITVNPNDVVTVVYTFYFKKPLTTNFAYMFLAFLYNAKDQVVPLNATDGSTFTFNVAVAVPINTTISVFTSSGTVSVKEPTVTVGPGVWALSQAFKFTSNDYVTRIQLRVRFENGKDVVIVDYVPSQPIPVKPDRPYIFSVSFSYPFVNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D5</accession>
    <name>A1S1D5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1870"/>
    <dbReference type="EnsemblBacteria" id="ABL79265">
        <property type="protein sequence ID" value="ABL79265"/>
        <property type="gene ID" value="Tpen_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1870"/>
    <dbReference type="eggNOG" id="arCOG06086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202940_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="53" mass="6520" checksum="F8AE10659D3C9F5F" modified="2007-02-06" version="1">MEGFRRELKERALRALREGVKGVDLERALREFEETRSEVWRELEKKYRERGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW57</accession>
    <name>A1RW57_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751702.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0027"/>
    <dbReference type="EnsemblBacteria" id="ABL77437">
        <property type="protein sequence ID" value="ABL77437"/>
        <property type="gene ID" value="Tpen_0027"/>
    </dbReference>
    <dbReference type="GeneID" id="4602077"/>
    <dbReference type="KEGG" id="tpe:Tpen_0027"/>
    <dbReference type="eggNOG" id="arCOG01131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_2"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="400" mass="45382" checksum="22169C8B7EB1D77D" modified="2007-02-06" version="1">MSKTRLSERIGRLDYPIRKYNALARSLEEKGEKVIYLNIGDPLKYDFTPPSELVEEACRALREGHHYYSPSEGLKELREAIAFKEKSWNGVQVDPKNVLVTNGVSEGINALYAALVNEGDEVLIPDPSYPLYINFADFYNAKKVFYRTLEEEGWRPDPDDIRRKITDKTRFIVINNPHNPTGAVYPEKTVKEILDIAAEHGLPVVSDEIYDALVFEGSFKSTAAVASEDNVVIGMNGFSKTFLVTGWRLGYIYLRGPEEKIADLRAALLGFLMTRLSAVTPLQVALARFAVKAPKHLEDLKRRLDERRRYTVRRLNEIPGVSLATSPAGAFYAFPRIDVDMDDEEFTKRLLLEEKVFVVYGSGFGPLGARHVRLVFLPPVQQLEEAFVRMERFMRRVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA9</accession>
    <name>A1RWA9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751754.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0079"/>
    <dbReference type="EnsemblBacteria" id="ABL77489">
        <property type="protein sequence ID" value="ABL77489"/>
        <property type="gene ID" value="Tpen_0079"/>
    </dbReference>
    <dbReference type="GeneID" id="4600711"/>
    <dbReference type="KEGG" id="tpe:Tpen_0079"/>
    <dbReference type="eggNOG" id="arCOG14765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127140_0_0_2"/>
    <dbReference type="OrthoDB" id="89307at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="268" mass="30449" checksum="367554C23118291E" modified="2007-02-06" version="1">MSKLGVQRVFRARCPACSQVEVVEVNDKLLEEAQNNPLGLAGVAFQHETHVFIVYVDRNGGERGTRVFPLLQARGKGLYEVKVQPELLRGLRNIGGFTIESRRLNYRVTGYFEPPSSSIKVYKGETSLEVDFRRDVSYQTTKAWMELLAEALDSSYSYSPTDYVNAVRLLDVLIEEKPFEYIKQVFWLITNASNITVKVRPSEAMLLRKYRPSIIFEKYNGGFVNRVLEAPSVKVSDILGLENPQIMFSYVEALLSLQRRGVIDLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB1</accession>
    <name>A1RWB1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751756.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0081"/>
    <dbReference type="EnsemblBacteria" id="ABL77491">
        <property type="protein sequence ID" value="ABL77491"/>
        <property type="gene ID" value="Tpen_0081"/>
    </dbReference>
    <dbReference type="GeneID" id="4600811"/>
    <dbReference type="KEGG" id="tpe:Tpen_0081"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="398" mass="44714" checksum="DB186989902D95BD" modified="2007-02-06" version="1">MGWETSFRLSKAASQLGAEEAFVYLARSLELKRRGVDVVSFGIGQPDFQPPPHVISEAKKAMDEGFNGYGPSLGMPELREAIASFVSEEYGVDVKAEEVAVTVGAKSAIFMAMISLLEPGDEVIIPDPSYPLYESVARFAGAKPVFLRLHRGNGYKVTFEEVEKLVTPKTRMIVLNYPENPVGTTMDQRDVEELVDFSAKRGIVVLSDEIYDHFVYEKKHFSTLQTSSWRDAVYYVNGFSKTFGMTGWRLGYVISNKELISKLSVVANNIYSCPVTFEQIAAAKALKEGLSWFKPILEGYRKRRDLIYREFLSIKGVKVVKPEGAFYIFPDFTEVIREKGLKNERELADRLLEERGVVVLPGTAFPKEGGKGHLRFSFAVSENDIVRGIARIKEWIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB3</accession>
    <name>A1RWB3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751758.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0083"/>
    <dbReference type="EnsemblBacteria" id="ABL77493">
        <property type="protein sequence ID" value="ABL77493"/>
        <property type="gene ID" value="Tpen_0083"/>
    </dbReference>
    <dbReference type="GeneID" id="4600361"/>
    <dbReference type="KEGG" id="tpe:Tpen_0083"/>
    <dbReference type="eggNOG" id="arCOG07757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021626_0_0_2"/>
    <dbReference type="OMA" id="EHICKNI"/>
    <dbReference type="OrthoDB" id="131067at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="122" mass="13739" checksum="9739A43D7B978CFF" modified="2007-02-06" version="1">MENVGRDVKALMRKLLLNSNAFFSNGYLNSEGRKVFEEMARFLVYEKPFLKRRIRRVRKEGSLEEVVRLAESILGEEAVSEILRSQHQGPYAVKGSPDEALASLQAPGCSTRLTDKIPSSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB5</accession>
    <name>A1RWB5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="8" type="ordered locus">Tpen_0085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0085"/>
    <dbReference type="EnsemblBacteria" id="ABL77495">
        <property type="protein sequence ID" value="ABL77495"/>
        <property type="gene ID" value="Tpen_0085"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0085"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="290"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="463"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL77495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="613" mass="67345" checksum="23F7671DE7B2AC52" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWD1</accession>
    <name>A1RWD1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751776.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0101"/>
    <dbReference type="EnsemblBacteria" id="ABL77511">
        <property type="protein sequence ID" value="ABL77511"/>
        <property type="gene ID" value="Tpen_0101"/>
    </dbReference>
    <dbReference type="GeneID" id="4601716"/>
    <dbReference type="KEGG" id="tpe:Tpen_0101"/>
    <dbReference type="eggNOG" id="arCOG00474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031500_2_0_2"/>
    <dbReference type="OrthoDB" id="88805at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="27319" checksum="76EC6DE501F68CB4" modified="2007-02-06" version="1">MSRVEDSVQQRKAELRRSVWSKLERMEVAISPRPCYGKIPSFVGIHSATQRLIKTDVYRNARVVYSTPDTSTRLLREETLRRGKTLVVSIPGLKGYVIVRPDELEPGDVRLASSVKGAVTKGDRITLLEGLKIDLVVLGSVAVNTDGARLGRGDGMHDLEYALLREMYAVAESTPVATLVHDLQILEEPIPMLMHDVPIDYIASPYRLITVERKHRKPPGVIWEMLPIDFIKSTPILRRLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWG3</accession>
    <name>A1RWG3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein, transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751808.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0133"/>
    <dbReference type="EnsemblBacteria" id="ABL77543">
        <property type="protein sequence ID" value="ABL77543"/>
        <property type="gene ID" value="Tpen_0133"/>
    </dbReference>
    <dbReference type="GeneID" id="4602176"/>
    <dbReference type="KEGG" id="tpe:Tpen_0133"/>
    <dbReference type="eggNOG" id="arCOG02402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682608_0_0_2"/>
    <dbReference type="OrthoDB" id="140822at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="403" mass="42468" checksum="7354BF187BFDC28D" modified="2007-02-06" version="1">MVDTLKLALLFVLGLQTAFTPCYLPVVPVFLAVISRQKAKRWLASLLFATGVVLSFVVYGILIGLGGGVVRYIFALLPQQLISTALGLILISIGVALLTPLREVFSYIPSATPSRKVSGYLGSFMFGFMFSLAAAPCAAAVMIAALSQALLGSFTDSLQPVLYMVVYGAGTGLPFLAIGALGGALRFRGGAGFLVRRAEEATGLLLVVTGSASILTIEHFEVVVFEVAKEMYPAVLSFLGLAGVYYSYVSFRAGAYLESPHPILIGAGLTLLSASLLASWTVPSAGNIATLVGLVGRALVLLGALSITLKGVLAGLIPVPPYLQAALDALLAVAFLASPRGDRNMRLASLFFLSLFLLDLPVNLPWDLSPFFVVFSVLSGLSIILSGLRTARVLSVLSLYERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI4</accession>
    <name>A1RWI4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751829.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0154"/>
    <dbReference type="EnsemblBacteria" id="ABL77564">
        <property type="protein sequence ID" value="ABL77564"/>
        <property type="gene ID" value="Tpen_0154"/>
    </dbReference>
    <dbReference type="GeneID" id="4601263"/>
    <dbReference type="KEGG" id="tpe:Tpen_0154"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_0_1_2"/>
    <dbReference type="OMA" id="IGPKTVY"/>
    <dbReference type="OrthoDB" id="76909at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="214" mass="23080" checksum="002310A12345AC68" modified="2007-02-06" version="1">MGSVNFRGVSITRLGHAAFRITDGKVVVYIDPFQVPSSPRDADIVVCTHDHYDHCSPDDIRKVAKQTTVVVASVNCAAKVKGLGYEYKLLNPGDRVAVKGVEIEAVPAYNVGKRFHPKDYKGIGVLVRLGDVVVYHAGDTDFIPEMASLKGKVSVALLPVSGTYVMDADEAVKAAETISPELAIPMHYGAIVGSESDARRFAEKLQGKVRVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWK0</accession>
    <name>A1RWK0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751845.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0170"/>
    <dbReference type="EnsemblBacteria" id="ABL77580">
        <property type="protein sequence ID" value="ABL77580"/>
        <property type="gene ID" value="Tpen_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="4601425"/>
    <dbReference type="KEGG" id="tpe:Tpen_0170"/>
    <dbReference type="eggNOG" id="arCOG14718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786710_0_0_2"/>
    <dbReference type="OrthoDB" id="76029at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="363" mass="41050" checksum="119AE763E536A3A9" modified="2007-02-06" version="1">MERRAQALLFLCLLLFLAFGEPVITQPRYWIALNFRLTFNADGTVRVDEKLHPFTVDGRSLLNDPEVAQDMNRSLSQMVNYALLMFSDNPRLLTYRVVKYMEKSYGETVLCDVTGTGRMERFTGAYIVSIVIWLNTSNYVRSLNDSLYEVKVRDSFTSTDPRSWIDVLEVVFNGTRLYGYRWEPPYAHGPERLGGGLLWVNHNEQEAPDFYVFQLEIPGLRKVGEPPEVKAVIEDAVILADGLHVTVKNVGSTSGYVYIRVLSQPEQARKVYLFVGEKLDVVFPSVRNAPVEVELYSGDSILDRARATRLEIAQPPLWSPHLLLVVTIPIFIAAILAVFLARRASREAREKQTVMGEGLSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL2</accession>
    <name>A1RWL2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751857.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0182"/>
    <dbReference type="EnsemblBacteria" id="ABL77592">
        <property type="protein sequence ID" value="ABL77592"/>
        <property type="gene ID" value="Tpen_0182"/>
    </dbReference>
    <dbReference type="GeneID" id="4600884"/>
    <dbReference type="KEGG" id="tpe:Tpen_0182"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_3_1_2"/>
    <dbReference type="OMA" id="AEHHRES"/>
    <dbReference type="OrthoDB" id="108931at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="194" mass="21462" checksum="DF93C5DF1EC65807" modified="2007-02-06" version="1">MGIRQILKIALREGVATLEYPFKPEEAPEDFRGKPEIDPSICMGCGACANVCPPDAITCVDDLERGLRTWKIFYGRCIFCGRCEEACPLSAIRQSKEYELASKTREDLEVVVETPLARCSTCGKYFPVTEREVAQAAQILAEAKTLPRSVLELLENGVECPECKRRRTVLSIVKSARPGVKPLSVTGEEGGRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR3</accession>
    <name>A1RWR3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secY</name>
        <name evidence="4" type="ordered locus">Tpen_0233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751908.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0233"/>
    <dbReference type="EnsemblBacteria" id="ABL77643">
        <property type="protein sequence ID" value="ABL77643"/>
        <property type="gene ID" value="Tpen_0233"/>
    </dbReference>
    <dbReference type="GeneID" id="4600703"/>
    <dbReference type="KEGG" id="tpe:Tpen_0233"/>
    <dbReference type="eggNOG" id="arCOG04169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OMA" id="KWGIGSG"/>
    <dbReference type="OrthoDB" id="13531at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Plug_translocon" evidence="3">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="476" mass="52035" checksum="ED90B77E35A4C9F4" modified="2007-02-06" version="1">MGLKESLDSVFRFLPEIEKPRRKPPLSERLLWTALVLVAYFVMGQTPLYGIPRQTQGTLGALEFLRVVMASKRGTLIELGIGPIVTSGIVWELLVGSRIVNLDLTTPEGRRTFAGLQKLTAFLFAALEAAAYILGGVYGALTQQQQIIVFVQLFVASTFVILMNDMLEKGWGIGSAVSLFIAAGVAQQIFWELFSPIGPLGDGLYYGLFPSLFSALVSGNSTLLMHVVVRPSGYPDLVGFVGMVVMLLLLTYMESMKITIPVSSVRFGGAKTRIPLKFLYVSVMPVILVGALYANVVMFTQALWPRVNPGNQNPWLNVIAKYNYTEYGPVPLPGSFVYYISPPRSLASALADPVHLVVYSLLYIGFAVLFGVAWILTSGMDPETQAEQLAKAQLQIPGFRKSEKVIASMLKRYIWGLTILSSIIIGVIAVVSDIFRVMGGGTGILLLVGIIVQYYSILASERALEMYPSLARLIGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS0</accession>
    <name>RS8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps8</name>
        <name type="ordered locus">Tpen_0240</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWS0"/>
    <dbReference type="SMR" id="A1RWS0"/>
    <dbReference type="STRING" id="368408.Tpen_0240"/>
    <dbReference type="PRIDE" id="A1RWS0"/>
    <dbReference type="EnsemblBacteria" id="ABL77650">
        <property type="protein sequence ID" value="ABL77650"/>
        <property type="gene ID" value="Tpen_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0240"/>
    <dbReference type="eggNOG" id="arCOG04091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000305773" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="129" mass="14366" checksum="24B664B1477D2952" modified="2007-02-06" version="1">MMLDTLANALSTIMNNEVRGKKQCVIYPSSKLIVAVLDTLKRSGYIGDFELIDDGRGGKIVVNLLGRINKIGVIKPRYPVKKNEFEAWEREYLPSRDVGLLIVSTPKGVMTHREAKEKGLGGVLLAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT5</accession>
    <name>A1RWT5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0255"/>
    <dbReference type="EnsemblBacteria" id="ABL77665">
        <property type="protein sequence ID" value="ABL77665"/>
        <property type="gene ID" value="Tpen_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0255"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="APYWTTY"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="411" mass="46586" checksum="34E8C2762C11F05D" modified="2007-02-06" version="1">MRHGHITSVGMPRLASKPQAITASPIRRIAALLDEARRKSDIISFGGGAPSLPPPQEVVDFLVDFLKNNPQKSVAYGSTRGMIELRELIAQDLKKYWGVDYDPKDEIIIVNGGTEGIYLALSAILEPGDEVIVLDPTYLGYHEPVKLLGGRVRTVPVTVENGYQPRIEDVKKVISPLTKAFILLSPDNPTGRVVTEEFVRGLVDLAVEHDFWIVFDAVYKHISYGRPTPWVDSFKGARERTITINSFSKEASIPGFRLGYVTAPREVVEVMEKIKQYVSLAPDTPGQIAMIKFLESGIKDRYLQEVVIPTYRKRRDFMYKCIQEYLPEAKTSLPEGAFYFFVNIEEYLKAMGRDDEEFANRLLYRKSVVVIPGRYFGEMGKNHIRMTFVSEPEERIEEGIKRMSAYVSSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWV8</accession>
    <name>A1RWV8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ordered locus">Tpen_0278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751953.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0278"/>
    <dbReference type="EnsemblBacteria" id="ABL77688">
        <property type="protein sequence ID" value="ABL77688"/>
        <property type="gene ID" value="Tpen_0278"/>
    </dbReference>
    <dbReference type="GeneID" id="4602088"/>
    <dbReference type="KEGG" id="tpe:Tpen_0278"/>
    <dbReference type="eggNOG" id="arCOG04242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="OrthoDB" id="87367at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="154" mass="17632" checksum="0377FD261086FC3A" modified="2007-02-06" version="1">MSGKEEAIVIDGTGHIAGRLASVVAKRLLKGDRVVVVNAEKIVITGKPKRVVEKYLKRWVEWKTYYNPELRGPKYPKTPDRLFKRMVRGMLPMEKTIGRDSLKRLTVYVGLPDEYRNAKLVKVEEALFKNELVPYITLGELYKSLTNREVVSNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX0</accession>
    <name>RPO6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit Rpo6</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpo6</name>
        <name evidence="1" type="synonym">rpoK</name>
        <name type="ordered locus">Tpen_0290</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWX0"/>
    <dbReference type="SMR" id="A1RWX0"/>
    <dbReference type="STRING" id="368408.Tpen_0290"/>
    <dbReference type="EnsemblBacteria" id="ABL77700">
        <property type="protein sequence ID" value="ABL77700"/>
        <property type="gene ID" value="Tpen_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0290"/>
    <dbReference type="eggNOG" id="arCOG01268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_2_1_2"/>
    <dbReference type="OMA" id="KIGPPWL"/>
    <dbReference type="OrthoDB" id="126193at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000071698" description="DNA-directed RNA polymerase subunit Rpo6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00192"/>
        </source>
    </evidence>
    <sequence length="81" mass="9207" checksum="5B21122E886F8145" modified="2007-02-06" version="1">MKIGPPWLTRFERARIIGIRALQISLGAPVLIQVSEELSDPITIAEKELELGLLPIIVVRWTPEGKIQEIPIKYLKLRPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY8</accession>
    <name>A1RWY8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0309"/>
    <dbReference type="EnsemblBacteria" id="ABL77718">
        <property type="protein sequence ID" value="ABL77718"/>
        <property type="gene ID" value="Tpen_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0309"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="5321at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="192"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="419"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="639" mass="72197" checksum="466A92B0397FE414" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY9</accession>
    <name>A1RWY9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, containing PUA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0310"/>
    <dbReference type="EnsemblBacteria" id="ABL77719">
        <property type="protein sequence ID" value="ABL77719"/>
        <property type="gene ID" value="Tpen_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0310"/>
    <dbReference type="eggNOG" id="arCOG00985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_1_1_2"/>
    <dbReference type="OMA" id="IENIHYY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="151" mass="16783" checksum="4EB5ED57E4AA70DA" modified="2007-02-06" version="1">MKSSLGEVFATYFEKASRIEVASVKHEEIEEMYYVDGVLTVVKTRSAGLVPTLFFIYKNSVYPVFPNVYVDSGAVPRILNGADVMVPGIKKIDGEFKPGDRVLVREIEKNRVIALGIAIMGSDEIRGAQKGKAVRNIHYLGDELWELSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX06</accession>
    <name>A1RX06_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0327"/>
    <dbReference type="EnsemblBacteria" id="ABL77736">
        <property type="protein sequence ID" value="ABL77736"/>
        <property type="gene ID" value="Tpen_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0327"/>
    <dbReference type="eggNOG" id="arCOG01122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_2"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="98657at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="223" mass="24487" checksum="D4A00D5D35A69CBD" modified="2007-02-06" version="1">MKLNAAREAARHVRDGMVVGLGSGTTVKIFIDVLAERVRQENLTIFFVSSSIDTSLYAAGKGLLEVPLHEYTPEVSFDGADTVLPDRSLIKGGGGCLLREKIVDYYSKEYVVIVDATKVAETPRNLNVPVEVHPQAFKKVMEELRKSYGAVNVTLRTYEKGKLGPVLTDNGNFILDALFDELKDPLRLELSLKSVPGLIETGIFSVKKPSKIIVGYLHGVQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX07</accession>
    <name>A1RX07_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752002.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0328"/>
    <dbReference type="EnsemblBacteria" id="ABL77737">
        <property type="protein sequence ID" value="ABL77737"/>
        <property type="gene ID" value="Tpen_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="4600979"/>
    <dbReference type="KEGG" id="tpe:Tpen_0328"/>
    <dbReference type="eggNOG" id="arCOG15030">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327400_0_0_2"/>
    <dbReference type="OrthoDB" id="126283at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="102" mass="12170" checksum="3108C9A55A907D4E" modified="2007-02-06" version="1">MPDDVPGWPLMEEEVLILEGKDKIYFNFPYQLYKKELRRRLLRYNVEVNIKEDVLGGKRVEITVDKQVGLEIKAWLSIRLPTMREKYYVTELEEVSHAKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX18</accession>
    <name>A1RX18_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752013.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0339"/>
    <dbReference type="EnsemblBacteria" id="ABL77748">
        <property type="protein sequence ID" value="ABL77748"/>
        <property type="gene ID" value="Tpen_0339"/>
    </dbReference>
    <dbReference type="GeneID" id="4601706"/>
    <dbReference type="KEGG" id="tpe:Tpen_0339"/>
    <dbReference type="eggNOG" id="arCOG02459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945341_0_0_2"/>
    <dbReference type="OrthoDB" id="101884at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="296" mass="33810" checksum="EE34EF9206085495" modified="2007-02-06" version="1">MEEYVAVRAHGLKSRLLSREDYEQIVEETRDISSYHEYSIINEKDTLEEKLDKIYRVYVSRITILAQSSSELAPFFYALLDRLEFENVKIQLRSILGYARPVIYYPYGRHVGPARLSGIRSEGALWDSLREAGIQGVEKLKFTTGLVAEREAFVDFLYIAHLMSQVRALRISSSAKDALLEALEEEAGYMLAYWSRVLGLENLHPFLRILGLQGVAPRELGTSGSTTDLLRQALEEVTRRVVKPLEKKFPVSLPYAYAFNHYARLEASNLEKILLGKSIGLPKEVILRNLVFYDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX27</accession>
    <name>A1RX27_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752022.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0348"/>
    <dbReference type="EnsemblBacteria" id="ABL77757">
        <property type="protein sequence ID" value="ABL77757"/>
        <property type="gene ID" value="Tpen_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="4601459"/>
    <dbReference type="KEGG" id="tpe:Tpen_0348"/>
    <dbReference type="eggNOG" id="arCOG02144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192667_0_0_2"/>
    <dbReference type="OMA" id="VEWANHA"/>
    <dbReference type="OrthoDB" id="127272at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="86" mass="9970" checksum="24ACF56C9B7F1865" modified="2007-02-06" version="1">MSEKSPRTRQHEIPLAPLRRIFRSQGAERISDDAVVFLREYLEKLAREIALEAIEASRHANRRTVTDEDVKFAISRLQRAHSSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX44</accession>
    <name>A1RX44_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752039.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0365"/>
    <dbReference type="EnsemblBacteria" id="ABL77774">
        <property type="protein sequence ID" value="ABL77774"/>
        <property type="gene ID" value="Tpen_0365"/>
    </dbReference>
    <dbReference type="GeneID" id="4601494"/>
    <dbReference type="KEGG" id="tpe:Tpen_0365"/>
    <dbReference type="eggNOG" id="arCOG01631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068443_2_1_2"/>
    <dbReference type="OMA" id="HEFRIPG"/>
    <dbReference type="OrthoDB" id="107370at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="PTHR13610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="4">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="161" mass="17920" checksum="02D2FA8A7D1194E0" modified="2007-02-06" version="1">MSVTVPYVPSPYEVIRKALEIAGLKSGELFLDPGCGDGRSLVIASKEFGAKAVGIEIRRDLLEQAMKNVIEAGVSGNVVLVNGSFFEVKFPKADVVFLYLLTSVNEKLKPKLLSELKPSTRIVSHDFEITGWRPVEVYNLEEGGRSHRIYYYVVEESSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX61</accession>
    <name>A1RX61_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0382"/>
    <dbReference type="EnsemblBacteria" id="ABL77791">
        <property type="protein sequence ID" value="ABL77791"/>
        <property type="gene ID" value="Tpen_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0382"/>
    <dbReference type="eggNOG" id="arCOG00551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1458262_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="198" mass="22626" checksum="2FE43B56B4B24841" modified="2007-02-06" version="1">MGVMSDYRDPGELLKVLKQELLNNSLQPISVDFYREALKAVARLGEDEKLLKEEVKKTLETIFLIRLKKEVDLLIKGVKLDEKSLPPEEYGVIEKIKETINGMEKVVFRGEDLEKSGRQVTSQAKGSSGEQRSKVEEFSFVYFRKSFSPTLDAPERGKSMKSALFKKGDFALIPKRLAREYKEQGTVEIIEELLEHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX62</accession>
    <name>A1RX62_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752057.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0383"/>
    <dbReference type="EnsemblBacteria" id="ABL77792">
        <property type="protein sequence ID" value="ABL77792"/>
        <property type="gene ID" value="Tpen_0383"/>
    </dbReference>
    <dbReference type="GeneID" id="4602151"/>
    <dbReference type="KEGG" id="tpe:Tpen_0383"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_1_2_2"/>
    <dbReference type="OMA" id="MPVMLAP"/>
    <dbReference type="OrthoDB" id="110748at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="186" mass="21315" checksum="18779F9EA7C293D0" modified="2007-02-06" version="1">MGRQKILVLSWEQFFLDSVQLSKKIIENGYRPDILVAIARGGWVLGRILSDLLSVRDAVALTMKFYEEVGSHKERPVLVQELNVDLRGRKVLLVDDIVDSGATLREAVNHLRKAEPLEVRTATLYVKTWSPFKPDFYVKELSEWVVFPYELKETYQSLGRSEEYLAKMKEAGISEEILREILGTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD5</accession>
    <name>A1RXD5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative circadian clock protein, KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752130.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0456"/>
    <dbReference type="EnsemblBacteria" id="ABL77865">
        <property type="protein sequence ID" value="ABL77865"/>
        <property type="gene ID" value="Tpen_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="4601859"/>
    <dbReference type="KEGG" id="tpe:Tpen_0456"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_0_0_2"/>
    <dbReference type="OMA" id="YIRVLVM"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="285" mass="32083" checksum="90B0E073BC3D78CA" modified="2007-02-06" version="1">MFTRKTSKEEGRTARLPDEIPVPDEAQSAETNVVVHEAESKKWGYQLAKLGVEGLDERIGGLLRGRTYLVTGETGTGKTMFSLTFLMEGLRSNEPGIYVLVDEEYSDFMNGVYDFGWDFESYIRSGQLRILTLMPDFVERMKNKPVDTVVRSIVDGILQEARAIRAQRLVIDPVAPLIVNEGDLAWTREYIKSLIINLEKRIGATTLIVSEIPTGSTALSRFGVEEFLAAGVFVLGIERVRNTFYRTLYVRKMRWRPVPPQIFVFDIVRGKGVVVKGELGSIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD7</accession>
    <name>A1RXD7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0458"/>
    <dbReference type="EnsemblBacteria" id="ABL77867">
        <property type="protein sequence ID" value="ABL77867"/>
        <property type="gene ID" value="Tpen_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0458"/>
    <dbReference type="eggNOG" id="arCOG04430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_3_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="371" mass="41162" checksum="8EEB391E91C3C22A" modified="2007-02-06" version="1">MVQRLRRIRQLGPADLVYPGAVHTRFSHSLGTLYLAERIAKSAGIEDEGEVESLRLAALLHDVGHMPFSHALSSNHEKVSQEVVRSMLGDLLGKDLKHGVIDILAGSSRLSPILASEVDADRLDYLLRDSKHTGVSYGNVDVDRAVRSARLVRTEAGWALGFVHGAETAVENILLARTQLFRVVYYHRTVGAFEAVLRAAYAMLVEEGYLPSLDEALEEKELWCMFDDCMVIEALKRARKSEEDRLKELATSFLLRKPPKLVFEAYLSDGPGEGFRRELYEHALKGTAEELLVEKCGVPEGCLLVYLARIVPIGNVNRLLILHGESAKPLVSLSSTLLSYLKGVSLSPLRVYAFPECLRQATECLSRLAVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXH7</accession>
    <name>RL24E_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl24e</name>
        <name type="ordered locus">Tpen_0500</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXH7"/>
    <dbReference type="SMR" id="A1RXH7"/>
    <dbReference type="STRING" id="368408.Tpen_0500"/>
    <dbReference type="EnsemblBacteria" id="ABL77907">
        <property type="protein sequence ID" value="ABL77907"/>
        <property type="gene ID" value="Tpen_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0500"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OMA" id="RIYTCAF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_L24e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="PTHR10792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000148455" description="50S ribosomal protein L24e">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <sequence length="63" mass="7192" checksum="00AA5F03869ECAEE" modified="2007-02-06" version="1">MPRIVYCAFCGSPIKPGEGISYVKNDGTVLRYCSSKCFKSAIKYHRDPRRQKWVRKQVAHGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI5</accession>
    <name>A1RXI5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752180.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0509"/>
    <dbReference type="EnsemblBacteria" id="ABL77915">
        <property type="protein sequence ID" value="ABL77915"/>
        <property type="gene ID" value="Tpen_0509"/>
    </dbReference>
    <dbReference type="GeneID" id="4601006"/>
    <dbReference type="KEGG" id="tpe:Tpen_0509"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="OrthoDB" id="52310at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="309" mass="33963" checksum="72D62BD80B426960" modified="2007-02-06" version="1">MYGALELYSRSVSPKLFGNECSFEESAYVVVGAPFDSTATGVPGQRFAPQRIREVSVELETFLPDLQIDVERLAVNDAGDLPVLTSVEALIDILGGVAREVLSSGKGLIMLGGDHFSSFPVLVEAAGNVDELGVLVFDAHLDLRDEYPVKCRYSHATVFRRLIEQTKNVYIAYYKPRGWSSEEYEFMRQSPRKLAVLNTREEVESWVKEHRTVYVSIDIDALDPAYAPGTGTPEPIGLAPRELVDSLRAAVLGSEKLLGIDVVEVNPLVDVNNLTSRVAAKILLEALAAMYEARKIGACTRTSKHFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI9</accession>
    <name>A1RXI9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Tpen_0513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0513"/>
    <dbReference type="EnsemblBacteria" id="ABL77919">
        <property type="protein sequence ID" value="ABL77919"/>
        <property type="gene ID" value="Tpen_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0513"/>
    <dbReference type="eggNOG" id="arCOG01180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_3_3_2"/>
    <dbReference type="OMA" id="PYGFYRN"/>
    <dbReference type="OrthoDB" id="44076at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="11">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABL77919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="241" mass="27883" checksum="CA488A056256E04D" modified="2007-02-06" version="1">MAEKDSSVREVLEDVFDQRTVLAVLHLMNRGVLAKLYGTVSTGKEARVYWGKDRDGRDLAVKIYLIVTAEFRRGRLKYILGDPRFEGASLRGRELIYAWARKEYRNLRRASQFGIPCPKPIAVYENILVMEFIGRDGVPAPLLKDSPPSRPYEAFRELQSYIERMVLEAGLVHADLSEYNILVEDDRLVIIDWGSAVLSSHPNAEEFLLNDIRNVYRFFRELGVDTGRPEEFFEHIRSQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK8</accession>
    <name>A1RXK8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0532"/>
    <dbReference type="EnsemblBacteria" id="ABL77938">
        <property type="protein sequence ID" value="ABL77938"/>
        <property type="gene ID" value="Tpen_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0532"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8439" checksum="DC0D5947F5F04951" modified="2007-02-06" version="1">MSDPRVTVRTIGTLSRLLASTLRRDGLYEARLVEALDAVEEFLASVRGATPRIEEDEKLARELEEDIEGLRGLGLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXM2</accession>
    <name>RL10E_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl10e</name>
        <name type="ordered locus">Tpen_0546</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752217.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXM2"/>
    <dbReference type="SMR" id="A1RXM2"/>
    <dbReference type="STRING" id="368408.Tpen_0546"/>
    <dbReference type="PRIDE" id="A1RXM2"/>
    <dbReference type="EnsemblBacteria" id="ABL77952">
        <property type="protein sequence ID" value="ABL77952"/>
        <property type="gene ID" value="Tpen_0546"/>
    </dbReference>
    <dbReference type="GeneID" id="4600503"/>
    <dbReference type="KEGG" id="tpe:Tpen_0546"/>
    <dbReference type="eggNOG" id="arCOG04113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="82104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_L10e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_L10e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000026198" description="50S ribosomal protein L10e">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <sequence length="168" mass="18762" checksum="9C93D96E4F21FB62" modified="2007-02-06" version="1">MPLRPGRCYRHFGTPPYTRLEYIKSNPPVLIPKFDLGNPKGNFNTVLKLVVMRPGQIRANALEAARQHANKYLTAKVGEANFFLRVAVFPHHILRENKMMAMAGADRLQDGMRLSFGTPVGRAARVEAGQIVMLVKVDAKNIDHAKEALRRAASKIPLPSRIIVEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN8</accession>
    <name>A1RXN8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752233.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0562"/>
    <dbReference type="EnsemblBacteria" id="ABL77968">
        <property type="protein sequence ID" value="ABL77968"/>
        <property type="gene ID" value="Tpen_0562"/>
    </dbReference>
    <dbReference type="GeneID" id="4600605"/>
    <dbReference type="KEGG" id="tpe:Tpen_0562"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_2"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="OrthoDB" id="93754at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="167" mass="18744" checksum="5A88FE089F161E68" modified="2007-02-06" version="1">MDVLWAPWRMAYIEYAKIERGEGCFICKAVESSELEENLVVYKGEKIIVMLNRYPYNTGHLLVAPTRHVADFSQLSDEELFSLAKAVSLSLELLKKALSPDGFNVGVNLGRVAGAGLESHLHVHVVPRWNGDTNFMPVIADAKVIPEALKDTRRKLLKHVDVFEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP5</accession>
    <name>A1RXP5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone deacetylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752240.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0570"/>
    <dbReference type="EnsemblBacteria" id="ABL77975">
        <property type="protein sequence ID" value="ABL77975"/>
        <property type="gene ID" value="Tpen_0570"/>
    </dbReference>
    <dbReference type="GeneID" id="4600614"/>
    <dbReference type="KEGG" id="tpe:Tpen_0570"/>
    <dbReference type="eggNOG" id="arCOG00324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_2"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="34461at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="54"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="360" mass="40154" checksum="34E01117513F72B3" modified="2007-02-06" version="1">MKREDYAQLHVVWGEGYDEISFTPFSLRDEWTLARRLFYEKYLGFLRRTFKVEVHEVKRYPESVLLLAHDKEYVDYVKRMSELGAGLLDYGDTPAYPGVFEKALLAVSGTLTLADILVKAGRGVAFNPQGGFHHARRRSAGGFCVFNDVAVAARYVRERGYERVAIIDVDAHHGDGTQEILYRDPLLKVSVHGYGYGFYPGTGWIDELGEGDGLCMNINVPIPLTSADDVFELVVRELLAPLISSYSPDFVIVQSGVDAYRGDPLVGLRLTDNSYKVFAEFLSGIAARGVPVLLTGGGGYQPEVTARTWAFILSCVAGRCLEELGPLDEKTSSDRKTVEIVSSRIDYLLRSLKECEVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXS3</accession>
    <name>A1RXS3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752268.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0598"/>
    <dbReference type="EnsemblBacteria" id="ABL78003">
        <property type="protein sequence ID" value="ABL78003"/>
        <property type="gene ID" value="Tpen_0598"/>
    </dbReference>
    <dbReference type="GeneID" id="4601238"/>
    <dbReference type="KEGG" id="tpe:Tpen_0598"/>
    <dbReference type="eggNOG" id="arCOG00925">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="OrthoDB" id="42569at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="253" mass="27911" checksum="EEADC5DF5D0E0A7A" modified="2007-02-06" version="1">MEKGLLSVQHVRKSFGGVTAVKDVSLELGEGTLTMLIGPNGSGKTTLLNIISGVIEPDSGRIVFKGRDITRLYPHERYRYGIARSFQVPQLFTSLSVLENVLVSSRLYLEEDALGILFTNSWALKDWDQAQKAFEILSLLKLDHLWDAPARALSGGQMKLLELARALMSDPKLMLLDEPLAGVNPALAHEIMQALRRARDELGVSFLIVEHRLDLASKYVDFVYAMNQGTVISSGTPDEVFEDPMVVESLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXT0</accession>
    <name>A1RXT0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0605"/>
    <dbReference type="EnsemblBacteria" id="ABL78010">
        <property type="protein sequence ID" value="ABL78010"/>
        <property type="gene ID" value="Tpen_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0605"/>
    <dbReference type="HOGENOM" id="CLU_203625_1_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="41" mass="4705" checksum="EE4CAA82F7B5C405" modified="2007-02-06" version="1">MDAVEEFLASVGSVPARVEEDERLIRELEEEAEEFKRLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU7</accession>
    <name>A1RXU7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="8" type="ordered locus">Tpen_0623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752292.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0623"/>
    <dbReference type="EnsemblBacteria" id="ABL78027">
        <property type="protein sequence ID" value="ABL78027"/>
        <property type="gene ID" value="Tpen_0623"/>
    </dbReference>
    <dbReference type="GeneID" id="4601410"/>
    <dbReference type="KEGG" id="tpe:Tpen_0623"/>
    <dbReference type="eggNOG" id="arCOG03013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052778_0_0_2"/>
    <dbReference type="OMA" id="PSCATMQ"/>
    <dbReference type="OrthoDB" id="29893at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="PTHR10537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="356" mass="41061" checksum="BF68F9BE9A2DE2D8" modified="2007-02-06" version="1">MWPSSSAHTIRVILDTKDYAKYPFLREAVESIRETGLTLEDLERFDAVDDAKEKIKSVITRGEYPSIDDYQNEVPAFLTCIVILSEIGDSALSERFAVAFSKKVSENLKEEEKEERIEIAFHIASSVLGWSFDVDEKGTLIRLRYKDYLSGVPEYTGEWKLVNRLLDKGYVEVRKESFLRLIETGVKKYVLRLIEQTKVDEARIPPKLYSAVEEIASIWSKQREELLTYARNASKGKREDLFPPCIRAIIQDISAGKNLPHSARFALASFLLSVGFSVDEVLEVFKLSPDYREDIARYQVEHIAGMRGSRTKYLPYKCDNMRSYGLCRWRCENIRHPLQFFFKAARGRAPRVTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX3</accession>
    <name>A1RXX3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase of the DNA polymerase beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752318.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0651"/>
    <dbReference type="EnsemblBacteria" id="ABL78053">
        <property type="protein sequence ID" value="ABL78053"/>
        <property type="gene ID" value="Tpen_0651"/>
    </dbReference>
    <dbReference type="GeneID" id="4601518"/>
    <dbReference type="KEGG" id="tpe:Tpen_0651"/>
    <dbReference type="eggNOG" id="arCOG04066">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217517_0_0_2"/>
    <dbReference type="OMA" id="MATPWHL"/>
    <dbReference type="OrthoDB" id="109188at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009185">
        <property type="entry name" value="Nucleotidl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005928">
        <property type="entry name" value="Nucleotidltrnsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="235" mass="26928" checksum="AF7F913A2D413152" modified="2007-02-06" version="1">MYRRKASDEVHVVYSEETWRVFRELREKARVALRCLDVLRIPVYVVGSVARGDVTRKSDVDLFLERCVAPSYVTGLLEECGFLVEKYEVIWASPQTAVKLVIHVEDNVKVTLPVTDLSPAEKEFPRFAGSVTSEDVDAGRRVAGVNKFLRFIEPTEDGHVEWSILGREEEVARRLGISLGTVLEREAMRMKRWARGKSGFLVHECLDPRLSPEDLLRRLATRNQLLRKKLEGVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXX8</accession>
    <name>A1RXX8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ordered locus">Tpen_0656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752323.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0656"/>
    <dbReference type="EnsemblBacteria" id="ABL78058">
        <property type="protein sequence ID" value="ABL78058"/>
        <property type="gene ID" value="Tpen_0656"/>
    </dbReference>
    <dbReference type="GeneID" id="4601614"/>
    <dbReference type="KEGG" id="tpe:Tpen_0656"/>
    <dbReference type="eggNOG" id="arCOG01342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131909_2_1_2"/>
    <dbReference type="OMA" id="ESHQEVY"/>
    <dbReference type="OrthoDB" id="127178at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="113" mass="13067" checksum="0C8789CAD0E51C83" modified="2007-02-06" version="1">MSVDQQTIAKYQQTLEELRAVTLSIQQYRGRLLEIERTLKALEQSQGGFVYRSMGNILIQTPREEVMKELNSEKELLQLRLEEFTKREKLLRERLASLEKQLRSALPTSSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ7</accession>
    <name>A1RXZ7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0675"/>
    <dbReference type="EnsemblBacteria" id="ABL78077">
        <property type="protein sequence ID" value="ABL78077"/>
        <property type="gene ID" value="Tpen_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0675"/>
    <dbReference type="HOGENOM" id="CLU_2461948_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="88" mass="9666" checksum="0AC0875CACAFDE3A" modified="2007-02-06" version="1">MAALIATIVLFTAVSVYTRYYGSPIYAVKVQRNLAVIAAYVMLHSNCTDVGYYLSKVNSTQPLPGQTTSWVVTWCNGTPVVRGFSWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ9</accession>
    <name>A1RXZ9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752344.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0677"/>
    <dbReference type="EnsemblBacteria" id="ABL78079">
        <property type="protein sequence ID" value="ABL78079"/>
        <property type="gene ID" value="Tpen_0677"/>
    </dbReference>
    <dbReference type="GeneID" id="4601043"/>
    <dbReference type="KEGG" id="tpe:Tpen_0677"/>
    <dbReference type="HOGENOM" id="CLU_2067938_0_0_2"/>
    <dbReference type="OrthoDB" id="142196at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="12943" checksum="E20658B7303A705F" modified="2007-02-06" version="1">MELEEAVLSVLLLSASFLIYTYWLQLANTWSGDAASLIRDVCAVSLSPPGTSMEGVYDVDVCVSGNVIATRYPVYSYCFPRINETAIKAPVKSDERCFSGRIRLKITKAGNVVTLERG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY31</accession>
    <name>TRM56_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0709</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752376.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RY31"/>
    <dbReference type="SMR" id="A1RY31"/>
    <dbReference type="STRING" id="368408.Tpen_0709"/>
    <dbReference type="PRIDE" id="A1RY31"/>
    <dbReference type="EnsemblBacteria" id="ABL78111">
        <property type="protein sequence ID" value="ABL78111"/>
        <property type="gene ID" value="Tpen_0709"/>
    </dbReference>
    <dbReference type="GeneID" id="4601590"/>
    <dbReference type="KEGG" id="tpe:Tpen_0709"/>
    <dbReference type="eggNOG" id="arCOG01857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OMA" id="VVHLTMY"/>
    <dbReference type="OrthoDB" id="83050at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000365323" description="tRNA (cytidine(56)-2'-O)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <sequence length="181" mass="20308" checksum="E8AAE2CA9CF4DEEB" modified="2007-02-06" version="1">MSTGRRVFVLRIGHRPVRDHRVTTHVGLVARAFGADGIFLEESVEESVIRTLRNVVENWGGDFKVLTTRDPRETVANWKKNGGIVVHLTMYGENISEELINLISGQGKDILVVVGGEKVPRWLFEEADFNVAIGNQPHSEVAALAVFLDRLFKGEELRREFPGAKLSIIPSKRGKIVVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY33</accession>
    <name>A1RY33_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752378.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0711"/>
    <dbReference type="EnsemblBacteria" id="ABL78113">
        <property type="protein sequence ID" value="ABL78113"/>
        <property type="gene ID" value="Tpen_0711"/>
    </dbReference>
    <dbReference type="GeneID" id="4601592"/>
    <dbReference type="KEGG" id="tpe:Tpen_0711"/>
    <dbReference type="eggNOG" id="arCOG05671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292088_0_0_2"/>
    <dbReference type="OrthoDB" id="124975at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="213" mass="24225" checksum="7D25DC2D19C6A0E5" modified="2007-02-06" version="1">MSDELRNVLSNLTDTERRIVEVYMQRGGSAKEIASLLNVSERTVYKALYKYRKLALEQGIDPSNFYLRKTIAGTAAKPVQQGVPSELLESIKQELVSELAKIVEESVQRALKSMLEDLVVPRQDQRAPVEPVKPAVLEPHYDQVLYRLSDVLEKLNYNIERLAEKIDRLDSSGTAKAIAHEPYSWQAKPITTEVSMPSYVQGNPWLEILSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY34</accession>
    <name>A1RY34_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0712"/>
    <dbReference type="EnsemblBacteria" id="ABL78114">
        <property type="protein sequence ID" value="ABL78114"/>
        <property type="gene ID" value="Tpen_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0712"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_0_2"/>
    <dbReference type="OMA" id="CYILPEM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="27077" checksum="3934F5F7643EAA0A" modified="2007-02-06" version="1">MEVFEAFKPVKKDTPVDRLDPRTRFAISVTLAALSVYSSSALIQVIVLASVFAVATLARRCRLLVKGAVGSLPILLMIFLLNFVFAPTPQGALTSFAMALRFLALMSAFSVFFMTTPPEELALSLEEIGVPRDYSLLITMSFRFVPTLATDVQLVMDALRSRGLELERGKLRVRIKNYVYLLVPLIVFEVRRSMMIAEALEARGYGSGVKPTRLVRLRFSYLDLLALTVLMFFVAMLRIAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY41</accession>
    <name>A1RY41_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0719"/>
    <dbReference type="EnsemblBacteria" id="ABL78121">
        <property type="protein sequence ID" value="ABL78121"/>
        <property type="gene ID" value="Tpen_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0719"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736507_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="16334" checksum="888FB30EB43C26A3" modified="2007-02-06" version="1">MLMGESGLWEEVEKKVSRVIEGVEATLREFVERENLSVADAKRILEELAPSFSLLAKKGVLEVLYTLLLLGPLSFTRILESTGLNRRTLSTRLKQLQSEGLVVKVREEGVEGSSRYALTEAGKATALLAIPLIYYISKQKRRGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY53</accession>
    <name>A1RY53_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752398.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78133">
        <property type="protein sequence ID" value="ABL78133"/>
        <property type="gene ID" value="Tpen_0731"/>
    </dbReference>
    <dbReference type="GeneID" id="4600851"/>
    <dbReference type="KEGG" id="tpe:Tpen_0731"/>
    <dbReference type="eggNOG" id="arCOG03733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217641_0_0_2"/>
    <dbReference type="OrthoDB" id="78045at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="260" mass="29787" checksum="FCEF84DFB9C9CD90" modified="2007-02-06" version="1">MAREVCPGLYKDQRGKFYCRYAGGAEVDPAFMPCLLEYWECPYYQQAKKAEEAKPKAEEVVVPVEAKPPETPRETAAVAPAPPVAAEEHASLVSEAEALIERAGELARIWEEYDRAAREVVERWEDVRERISRELAGVDATITAYVDELERLEKMRESGVIGEEEYGELKASLERRLAEKNKEREELSRVLADLDRVVLPHFKRVKVAEVKPEIAKLKVALAKLEERFKSGGISEEVYEKLRSELEERIKRLEKIKEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY56</accession>
    <name>A1RY56_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13e</name>
        <name evidence="5" type="ordered locus">Tpen_0734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752401.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0734"/>
    <dbReference type="EnsemblBacteria" id="ABL78136">
        <property type="protein sequence ID" value="ABL78136"/>
        <property type="gene ID" value="Tpen_0734"/>
    </dbReference>
    <dbReference type="GeneID" id="4601141"/>
    <dbReference type="KEGG" id="tpe:Tpen_0734"/>
    <dbReference type="eggNOG" id="arCOG01013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674077_0_0_2"/>
    <dbReference type="OMA" id="FRETHNY"/>
    <dbReference type="OrthoDB" id="114187at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_L13e"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="157" mass="17993" checksum="0A97BD956036C096" modified="2007-02-06" version="1">MSGQQSVQPPEPIVNAVKLRRYGGVPPRPLKVGRGFSEGEVKALGLTVKEARLLGIYVDERRKTVHPENVEALRSWLKALKEHLESGGELPEPTLPKKIIVKPDIHRVFKGKTMAGRRARGLLSVKYRYTHHYKWKKKQRERLLKKRHEATRHKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY59</accession>
    <name>A1RY59_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752404.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0737"/>
    <dbReference type="EnsemblBacteria" id="ABL78139">
        <property type="protein sequence ID" value="ABL78139"/>
        <property type="gene ID" value="Tpen_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="4601144"/>
    <dbReference type="KEGG" id="tpe:Tpen_0737"/>
    <dbReference type="eggNOG" id="arCOG01678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057642_0_0_2"/>
    <dbReference type="OMA" id="IGHPDSI"/>
    <dbReference type="OrthoDB" id="21658at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="406" mass="44168" checksum="1690ABA9C3D42028" modified="2007-02-06" version="1">MSAKNIVVEKSSYIPPSRLPVEIVERKGTGHPDYIADSISEAASRELSRYYLEHYGAILHHNLDKVLVVGGQSSPRFGGGEVVQPIYILVSGRATTEVVSEGGRESVPVGPIILKATRDWIKSNIRFLDPDTHVIVDYRVGKGSADLVDIYNRRGSYPGANDTSMGIGYAPLSPTERAVLETERLLNSEKVKKELPAVGEDVKVMGVRKGNKLTLTVAMAVISRFVHSTEEYLSLKEEVKKLVKEHAASITDLDVEVYVNTGDDPSRGDKGGLYLTVTGTSAEHGDDGATGRGNRANGLITPFRPMSLEATAGKNPVSHIGKLYNVVAFQAASEICGLDHVNEVYIKLISQIGKPINQPLLAYIAINAPDDVLARVKHQAEEVLAKHLDRINVLWESILKGNVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY89</accession>
    <name>A1RY89_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0767"/>
    <dbReference type="EnsemblBacteria" id="ABL78169">
        <property type="protein sequence ID" value="ABL78169"/>
        <property type="gene ID" value="Tpen_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0767"/>
    <dbReference type="eggNOG" id="arCOG04479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162441_0_0_2"/>
    <dbReference type="OMA" id="CLACGFT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="108" mass="12658" checksum="DAF0140547380150" modified="2007-02-06" version="1">MGYELTTREKLFRFFLENPGSEIDLYQLTRELGLRPSDYKEVLENINHVAKTIRRKSNGKMLLMMKPPMCASCGYVFRELEKARLPSRCPVCKSERIRPPSFMLVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA6</accession>
    <name>A1RYA6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, PadR-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752451.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0784"/>
    <dbReference type="EnsemblBacteria" id="ABL78186">
        <property type="protein sequence ID" value="ABL78186"/>
        <property type="gene ID" value="Tpen_0784"/>
    </dbReference>
    <dbReference type="GeneID" id="4601132"/>
    <dbReference type="KEGG" id="tpe:Tpen_0784"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346472_0_0_2"/>
    <dbReference type="OrthoDB" id="121339at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="203" mass="23181" checksum="024901EC61660A63" modified="2007-02-06" version="1">MTEADWKVGVAGEMGLTPVREPSLDDFVLLLLYLDGRTPIYGEEIIHFILAIYPFVSLRLSPSLYLPYFEAVSEALRRLEERGFIFRSRQAYRDGERRVVRLTETGSDEARKIFKAFSESWLLMRGVALRRGSEVLGELEALKKTYNGKGLVELARLLASKVEGDGASALNHLEGVSKEWVEYFVYLLKRLSKELKPTSRQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC3</accession>
    <name>A1RYC3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78203">
        <property type="protein sequence ID" value="ABL78203"/>
        <property type="gene ID" value="Tpen_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0801"/>
    <dbReference type="HOGENOM" id="CLU_1237973_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="247" mass="27899" checksum="FCD30CA0AA978024" modified="2007-02-06" version="1">MRWRRHHLQPATVIYRWLTHDWLVSIDRVRDEEGEPDEVEIVEVGEGDVALLLAALKRLNNGVYALKVTLDFLNTRVGTLQGQIKELEEALKSHLEAFQAENSRLAESVNRVSREFKEGTDTLTKNVQLSLDMFLEKLSGELTRLEDTLSTITQDVSAVMSKLKEVELVSTDAATAVKSDVNSLRGSMSNVELALNELSQRVTRLEESQLAALRQYSLELQEVSLKLTQVNQLLQKLLEKESKEPTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD8</accession>
    <name>SYP_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">Tpen_0817</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752483.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RYD8"/>
    <dbReference type="SMR" id="A1RYD8"/>
    <dbReference type="STRING" id="368408.Tpen_0817"/>
    <dbReference type="PRIDE" id="A1RYD8"/>
    <dbReference type="EnsemblBacteria" id="ABL78218">
        <property type="protein sequence ID" value="ABL78218"/>
        <property type="gene ID" value="Tpen_0817"/>
    </dbReference>
    <dbReference type="GeneID" id="4601988"/>
    <dbReference type="KEGG" id="tpe:Tpen_0817"/>
    <dbReference type="eggNOG" id="arCOG00402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="14454at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000288424" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <sequence length="482" mass="56335" checksum="DE03235CC18F4C5E" modified="2007-02-06" version="1">MSEQGITVSKSEDFSEWYSQVLSKAGLVDLRYNVQGFVVHKPWLMRIIKAIYRFFEEELEKTGHEPVLFPLVIPEENFEKEKEHVEGFKPEVFWVTQAGDEKLERRLALRPTSETAFYYMYSYWIQSWRDLPLKLYQSVSVYRNEKNTRPLIRGREFLWIEAHDAFATHEEALNQIREDMENSRKVIWEKLGIPFLFLRRPPWDKFSGAEDTYAADTIMPDGRVLQISSTHDLGQRFAKAFNVTFLDKDGKRKYVWQTCYGPGIWRITAALIAIHGDDKGLVLPMNVAPIQVVIVPIYYKESDKERVLEKCRKLEAMIREAGYRVYLDAREEYTPGWKFNDWELKGVPVRLEVGVREVETGTVTVFRRDLRVKEKVADSELISHIRKLENDILEELKRRAKEFFESRIVTATRREEVEEALRSGKMVKMPFCGREECADDLKEATDGGKVRGTEIDFKEGDYGRCAWCGAPARLIVYVAKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH6</accession>
    <name>A1RYH6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0855"/>
    <dbReference type="EnsemblBacteria" id="ABL78256">
        <property type="protein sequence ID" value="ABL78256"/>
        <property type="gene ID" value="Tpen_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0855"/>
    <dbReference type="eggNOG" id="arCOG09429">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100868_0_0_2"/>
    <dbReference type="OMA" id="QKYHEAN"/>
    <dbReference type="OrthoDB" id="139913at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="240" mass="26417" checksum="A0576F30A74B9721" modified="2007-02-06" version="1">MRIKELLESVVAVAITLFGAPGTYSLEEIAGKLRNLSLLKSRVNFLGKEFELGVRVEELRVEGGAVVGVLVEVYQEALDLDGESLVVPVKRRVRFAFVEYKGSLYLLVFAGRRLASRVAELLSENIYGSGGEIYGTYLSPEALRRIYGGKEVRQVVFESAEGRGLRTAVLYGEDLASALGEEFARNRSEKYVVYRDDAGVFGVSRNGVVVCFSPLTLEEIIEYLSEEVLPLLEPPPGTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYL0</accession>
    <name>A1RYL0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding ACT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0889"/>
    <dbReference type="EnsemblBacteria" id="ABL78290">
        <property type="protein sequence ID" value="ABL78290"/>
        <property type="gene ID" value="Tpen_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0889"/>
    <dbReference type="eggNOG" id="arCOG02316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100860_0_0_2"/>
    <dbReference type="OMA" id="EPTVHMK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014424">
        <property type="entry name" value="UCP004897_ACT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004897">
        <property type="entry name" value="UCP004897_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="176" mass="19882" checksum="516149870B13BEFF" modified="2007-02-06" version="1">MSIFVHVEGGFWRRVSEVVKSEKRMNVVRLLLKYGISVREDGLYIGDKVKVTVSSVAEEAQVDRRIVLETLKRILSDSYLREFFYNLRPAGPSLVSVARVLGYRCLVVEIHEDRPGILAWVASALAEKGINILQVVAEDPNIYREPKLYVVVSKPVPGEVIEKILQHPAVKRVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN5</accession>
    <name>A1RYN5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752580.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0914"/>
    <dbReference type="EnsemblBacteria" id="ABL78315">
        <property type="protein sequence ID" value="ABL78315"/>
        <property type="gene ID" value="Tpen_0914"/>
    </dbReference>
    <dbReference type="GeneID" id="4602127"/>
    <dbReference type="KEGG" id="tpe:Tpen_0914"/>
    <dbReference type="eggNOG" id="arCOG04234">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142655_0_0_2"/>
    <dbReference type="OMA" id="YVGYPII"/>
    <dbReference type="OrthoDB" id="101808at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016618">
        <property type="entry name" value="UCP014422"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014422">
        <property type="entry name" value="UCP014422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="148" mass="16719" checksum="EB23E3476BADF174" modified="2007-02-06" version="1">MEYWRVPPRVKVLEALGAIGDGRVVFVGEGEARVTGSDGSRVYRVVWDGKLGIASNDNGSVYRGYLGYPSIAVLMLKGILPFDAKLAEGLKGIPWREINERFKSYRETEAYVRSLLEEKGFSWAYVDAFIERVLSEIKRLKPYKVPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYQ6</accession>
    <name>A1RYQ6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0935"/>
    <dbReference type="EnsemblBacteria" id="ABL78336">
        <property type="protein sequence ID" value="ABL78336"/>
        <property type="gene ID" value="Tpen_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0935"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_2"/>
    <dbReference type="OMA" id="PDHNALI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="376" mass="41601" checksum="2E9CCECB02E4A25C" modified="2007-02-06" version="1">MYDVVIVGGGIVGVSLAYRLAEEGAGRVLLLEKGYLGGGSTFRCAGGIRASFTSREHIVLMKRSIELWGELREKLGVKYERSGYLWLISRERDVERFKEYSRVHNSFGVETRFVDEDFVKRVAPYVDTSSMVAALYDPLAGKASPFDAVYKQFLAARSLGVEFAVGREVDSVRVERGEARGVVVGNELIPARSVVVAAGAESVFLLRRSGVELPLAPVPHHAALTEEFGRLFDPLIIDVETGAYAVQTFHGHVLMGVEVEEEPFARPVVKLEFLEKVVSTWSKWLTWLPGANILRYWVGYYEVTPDHHPILGPVDGVENLYVATGFSGHGFMMAPVVAEELAEWIKSGKPKSEEAARLTLARFKEGRLIKELAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS8</accession>
    <name>A1RYS8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0958"/>
    <dbReference type="EnsemblBacteria" id="ABL78358">
        <property type="protein sequence ID" value="ABL78358"/>
        <property type="gene ID" value="Tpen_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0958"/>
    <dbReference type="eggNOG" id="arCOG00792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_4_2"/>
    <dbReference type="OMA" id="YANDITF"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="153"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="266"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="629" mass="71021" checksum="722EC9738257B863" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT3</accession>
    <name>A1RYT3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752628.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0963"/>
    <dbReference type="EnsemblBacteria" id="ABL78363">
        <property type="protein sequence ID" value="ABL78363"/>
        <property type="gene ID" value="Tpen_0963"/>
    </dbReference>
    <dbReference type="GeneID" id="4600767"/>
    <dbReference type="KEGG" id="tpe:Tpen_0963"/>
    <dbReference type="HOGENOM" id="CLU_955184_0_0_2"/>
    <dbReference type="OrthoDB" id="134622at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="291" mass="34241" checksum="20B16C4D885BF23B" modified="2007-02-06" version="1">MLSKQEFARWVEASHALFDLFDGKYDAYPFARKLAAQWLRHGEFTLDEEARRGLADSIRNFKYNVFGLGPRKRERIEPELWALLEAMEADRRNAGYAISIYFFTWNIRRFIKYIKENSYFSIVKYFESLGAKLEEMRNNLVHFADKHILRDEVEDKEIVNLFNRANQALKALGIGENEPVATAKLLHIFSPSYFPLIDNPIADCTGIKKIDAYTYTEWIHTLKNWLKNYTEEALQLEKNTGHTILKLVDEGLYTMCSITLKARIHSLGLPSKQPTLPRKTKHRKHRKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU5</accession>
    <name>A1RYU5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752640.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0975"/>
    <dbReference type="EnsemblBacteria" id="ABL78375">
        <property type="protein sequence ID" value="ABL78375"/>
        <property type="gene ID" value="Tpen_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="4600449"/>
    <dbReference type="KEGG" id="tpe:Tpen_0975"/>
    <dbReference type="eggNOG" id="arCOG02102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_3_2"/>
    <dbReference type="OMA" id="AMKIMVE"/>
    <dbReference type="OrthoDB" id="114771at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="8607" checksum="6EEEC6F90745889B" modified="2007-02-06" version="1">MRPEVIPLAMCPEGCEGIVVEVNGGMGLIRRLAELGFTKGARVRVLHSSPPGPVLVMVKGSRIALGRGVAMRVMISLQEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYY8</accession>
    <name>A1RYY8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1018"/>
    <dbReference type="EnsemblBacteria" id="ABL78418">
        <property type="protein sequence ID" value="ABL78418"/>
        <property type="gene ID" value="Tpen_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1018"/>
    <dbReference type="HOGENOM" id="CLU_1465193_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="222" mass="25134" checksum="707BD8ED116F3BCF" modified="2007-02-06" version="1">MRTSRTLYLYVTIQYTESKTPSGRAIRTNSFLTLEAVFRHMTVEYLDLSSIREGLWVVLDALVGLWRRKGYRASQAGILSGMGFDQLDPYLIVYGYISRGLLAKRSSAFQLTREGLEALTIVSDVAETIREDAEFPEFDGGKLLGAVVYALYDWQNSYPGAEEYLKYLGEVRERVARLKSENPKAFKLVAMTLPRLKFDEGYTVERLLDAAEKVALSHAHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ8</accession>
    <name>A1RYZ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752693.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1028"/>
    <dbReference type="EnsemblBacteria" id="ABL78428">
        <property type="protein sequence ID" value="ABL78428"/>
        <property type="gene ID" value="Tpen_1028"/>
    </dbReference>
    <dbReference type="GeneID" id="4600507"/>
    <dbReference type="KEGG" id="tpe:Tpen_1028"/>
    <dbReference type="eggNOG" id="arCOG04189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182708_0_0_2"/>
    <dbReference type="OrthoDB" id="142926at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="10502" checksum="33BB8681E53B3F20" modified="2007-02-06" version="1">MDKDRVAGAVLLAVAASLGSLYAYLLFLAQQEVQVLVMKLTALFVVETFFLVVAWVGLTLLTSPPEAKVREIERRLEEEYRKLREQGYPFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ04</accession>
    <name>A1RZ04_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752699.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1034"/>
    <dbReference type="EnsemblBacteria" id="ABL78434">
        <property type="protein sequence ID" value="ABL78434"/>
        <property type="gene ID" value="Tpen_1034"/>
    </dbReference>
    <dbReference type="GeneID" id="4600939"/>
    <dbReference type="KEGG" id="tpe:Tpen_1034"/>
    <dbReference type="eggNOG" id="arCOG05710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117974_0_0_2"/>
    <dbReference type="OMA" id="IDKAPHG"/>
    <dbReference type="OrthoDB" id="107143at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19171" checksum="57417FC2BA459823" modified="2007-02-06" version="1">MSDVYRSVSSRLRLLEKLELVIPGYRGYKEKELRREADRLIRSYLLSKLEPAYRDFKGAMKVVAATGDPSLAATYNEVQAVFDRVVSKLKTMSYGYTGFFDAVKIEEKELDKMLELDWSLASSVDKVVEKARAVAAAEPSKVSAALNDLRGELLAFEDLIVKRENAIKGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ14</accession>
    <name>A1RZ14_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">Tpen_1044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752709.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1044"/>
    <dbReference type="EnsemblBacteria" id="ABL78444">
        <property type="protein sequence ID" value="ABL78444"/>
        <property type="gene ID" value="Tpen_1044"/>
    </dbReference>
    <dbReference type="GeneID" id="4600787"/>
    <dbReference type="KEGG" id="tpe:Tpen_1044"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OMA" id="TPPRIRM"/>
    <dbReference type="OrthoDB" id="89944at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="268" mass="29550" checksum="CF70A7A7359F927F" modified="2007-02-06" version="1">MGVSGGVLPELDWRVVEEVITRELRRYVFEEAGKSGGVVGVSGGVDSAVTLLLTARALGPENTYALIMPSSATPEEDLRDAYEVVRIAGLPGGNVETVDIEPILSRFEESLGPLTRVERGNLAARVRMCILHARAYRRNSLVIGTGDKSELLLGYFTKYGDGGVDVLPIGDLYKTQVRRLGLHLGLPERIAFKPSSPRLWPGHVAEEELKLTYEVADKILYLLFDRGVDPSEVPGMLGVGRELVERVLELHRRSEHKRRPPYVIKVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ55</accession>
    <name>A1RZ55_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proton-translocating NADH-quinone oxidoreductase, chain M</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752750.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1086"/>
    <dbReference type="EnsemblBacteria" id="ABL78485">
        <property type="protein sequence ID" value="ABL78485"/>
        <property type="gene ID" value="Tpen_1086"/>
    </dbReference>
    <dbReference type="GeneID" id="4600934"/>
    <dbReference type="KEGG" id="tpe:Tpen_1086"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_2_2"/>
    <dbReference type="OMA" id="ITRWGNQ"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="137"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="500" mass="53466" checksum="B05710CB27F79D2A" modified="2007-02-06" version="1">MGVPYLWLALLVPLAASLASLALKSRKALAALNSSALAFSAAVLLLLYLTNGSNRWFDPLSFKLGSLGTFSLVMDPMVFLVAFSVAVTTSVIALYSSPYMEHRFEELEREGVSAPGWGAYYFLYTLFALSMMGTVMSTNIIEFYVFLELTLIPSFLLIAFYGYGERLKIAIMYLIWTHVGALLFLIGALTVGSKVGFDFVDPEKGFLLGLGEGVGVLAFWLMVVGLSVKLAAAGLHMWLPYAHAEAPTPISALLSPNLIGLGGAMMFRVVYVLFPKTFAAASPVLMAWALVTMIYGGLMALSQSDFKRLLAYSSISQMGYLLLGLASVDVYGVAGTFLHYMVHAFGKAILFAVAGILIATYHGLRDITRMGGLASKMPYTASLALIGFMHITGIPPTLGIWSEYLILRGAVAHALALGAPSYVLLAAALLVGIGLSTAYSFLTMRRVFYGPLKVPEAREAGKALWAPLLAFAVLGVLFFVCASLLIDPLVSSLGGLGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ82</accession>
    <name>A1RZ82_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1113"/>
    <dbReference type="EnsemblBacteria" id="ABL78512">
        <property type="protein sequence ID" value="ABL78512"/>
        <property type="gene ID" value="Tpen_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1113"/>
    <dbReference type="eggNOG" id="arCOG03769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152705_0_0_2"/>
    <dbReference type="OMA" id="VWLYALR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="100" mass="10920" checksum="E8FED032E1DE4182" modified="2007-02-06" version="1">MNFLVGWIVSGIAVWLALKLFPGKQKAESIPGAFLTALIGALIFWVFKVLHIPFGTLLAILVWLYALRKIQGVGWLGAAVLAVLVYLINALFGLFLPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZG8</accession>
    <name>A1RZG8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1200"/>
    <dbReference type="EnsemblBacteria" id="ABL78598">
        <property type="protein sequence ID" value="ABL78598"/>
        <property type="gene ID" value="Tpen_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1200"/>
    <dbReference type="eggNOG" id="arCOG14804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="229" mass="25653" checksum="642D8B0C1DE8A204" modified="2007-02-06" version="1">MATEIARILMRIQKHFAPTVHVLVPQMLFAYMVSSVAREVSSPSEVNKALFRNGVWSGTIAMTRMAKPEDLSALWPRRFDPGKLAGFVKVFGEGAWYIFAGHLPRLNAKPVADGVLWITIEEGEGKEAFYSIEVPEGVNVFYFLAGAYEGATQTAFRMLGEEERWISMWRPLPGGRGIHGFYALREIGAERIVEAAINADRDFFSTVSWEDSSRFAEELLGVKFPALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH0</accession>
    <name>A1RZH0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1202"/>
    <dbReference type="EnsemblBacteria" id="ABL78600">
        <property type="protein sequence ID" value="ABL78600"/>
        <property type="gene ID" value="Tpen_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1202"/>
    <dbReference type="eggNOG" id="arCOG00243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705184_0_0_2"/>
    <dbReference type="OMA" id="KHHFDEI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="403" mass="44570" checksum="F28654ABABED4137" modified="2007-02-06" version="1">MKIVVVGCGAVGSLVARLAAKWKVADEVLCLDKDVERAKRYLDYPEPLGIPVERADALAAEELKAKVAGYDFLVNSLPTFVKVDKAERLLNPQLMSVALKAGLNYADLACYGGKRRRAEQLSFSKAFSEAGLLALINMGASPGLSNILAREVYEDLDSAESLYVMSLEDQRGSSFVIPWSREEMLNVASPELCFRGRKYSLREPFSESALCNFPEPIGPVRCYSVSNDEAYTIPAFLRISNFYYLAGGSDIEVLRALYRLGILSDVPVKLRKATVTPRELLYHILPPTPSPEYIVRVVKEGDLEDAYFALQVYAEGEVRGERAVSKRYLVFPSQRRVNELMPGATYITYPTALSLLAVLSAVKGRRLRGVVPGEALPGPIRRAVLDYLRVQGITVGEEFRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZH2</accession>
    <name>A1RZH2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752867.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1204"/>
    <dbReference type="EnsemblBacteria" id="ABL78602">
        <property type="protein sequence ID" value="ABL78602"/>
        <property type="gene ID" value="Tpen_1204"/>
    </dbReference>
    <dbReference type="GeneID" id="4600406"/>
    <dbReference type="KEGG" id="tpe:Tpen_1204"/>
    <dbReference type="eggNOG" id="arCOG14935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891539_0_0_2"/>
    <dbReference type="OrthoDB" id="138902at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14644" checksum="8EBE327BDA3A753D" modified="2007-02-06" version="1">MSSDAQKWVQTAANFARVGELSVRIGILVAVVYGIFWAIKLFFEYIHGLQFLSRPFVEYMAFSAVSFAVAALTSYANERYSEKGNFRMAGLTALVAASVLLIPATVAGVLLLLGGLALYISAEIVNVAKIEFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL9</accession>
    <name>A1RZL9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1251"/>
    <dbReference type="EnsemblBacteria" id="ABL78649">
        <property type="protein sequence ID" value="ABL78649"/>
        <property type="gene ID" value="Tpen_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1251"/>
    <dbReference type="eggNOG" id="arCOG00674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655049_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="410" mass="45492" checksum="B5551A68DE53F8F0" modified="2007-02-06" version="1">MKGVVMFTEEDRCCYELKLCGVPVYLRVIAALIQGGVREIVCVNAPSRVKSALGDGRELNARVTYLDSAARVEGLGDAVLLEASTIIDVALVRAASTFKEDTVVLDEKSGGKVWVLRKASARLEGKSAGELPVILGELEKSSLKRVSVREIAFMDPELKREVEPLCVKIRDPLDAREVKKLLVKRAGKRLHITSRVNTVIEDRVVEMLCEHSWVTPNRVTLLVDLLAFMVAFFILQASLPLALVAAYLVGVLDGVDGKLARVRFPSKVGSLEHSFDALYEQTWYAFLAWRLFVDTGSHLPLMLGFAFLVVDTFVRHVYMQFKMTMGIPLTAYSRFDRAFAAIDGRRNVYLIYFLVSSLLGQPLCGLLAALAHALITATFYSLRALKHARNVDKASGLSRLLELSKSTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZQ8</accession>
    <name>A1RZQ8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1290"/>
    <dbReference type="EnsemblBacteria" id="ABL78688">
        <property type="protein sequence ID" value="ABL78688"/>
        <property type="gene ID" value="Tpen_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1290"/>
    <dbReference type="eggNOG" id="arCOG02666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318236_0_0_2"/>
    <dbReference type="OrthoDB" id="15660at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="167"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="914" mass="101650" checksum="99E8B490E1B71FF8" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S007</accession>
    <name>A1S007_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753052.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1390"/>
    <dbReference type="EnsemblBacteria" id="ABL78787">
        <property type="protein sequence ID" value="ABL78787"/>
        <property type="gene ID" value="Tpen_1390"/>
    </dbReference>
    <dbReference type="GeneID" id="4600673"/>
    <dbReference type="KEGG" id="tpe:Tpen_1390"/>
    <dbReference type="eggNOG" id="arCOG00726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_2_1_2"/>
    <dbReference type="OMA" id="ANTIWKA"/>
    <dbReference type="OrthoDB" id="116013at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14811" checksum="250DA17DA088493D" modified="2007-02-06" version="1">MTVVDASALAAFVLKEPGWKSLAEYLVGAVSVDMVVKEVANAVWKACRVRGYVGVEEARRLLRVLKSMIGVNIELRPEADYLDAAFEIAVEHGVTVYDALYLALAVEEGEPLLTLDERQLRVAGKLGVRVVEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>A1S035</accession>
    <name>A1S035_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753080.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1418"/>
    <dbReference type="EnsemblBacteria" id="ABL78815">
        <property type="protein sequence ID" value="ABL78815"/>
        <property type="gene ID" value="Tpen_1418"/>
    </dbReference>
    <dbReference type="GeneID" id="4600735"/>
    <dbReference type="KEGG" id="tpe:Tpen_1418"/>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187832_0_0_2"/>
    <dbReference type="OrthoDB" id="135466at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="231" mass="24084" checksum="967E5BE046828AC1" modified="2007-02-06" version="1">MRLLGVLLVAAVLLAPLAWGQPTLRIVAYDGTSLAGALVRVSTLDGRVYEFTLNPAAPFTVKDVVKGVLRVEVVSWKGVPVNYEKTVTVYENSTLVVPSIGRLTVAVKGARGQALPGALVTISRGGVTVEEGSAGSSGIYSTLLPAGTYEVAVAYGGRSARVEAVVEPSRESRVEAALDVVAEVGGWALSASELLGVSLLAVLAVFAVYVALYEYASWRKRRAARVVAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S053</accession>
    <name>A1S053_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753098.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1436"/>
    <dbReference type="EnsemblBacteria" id="ABL78833">
        <property type="protein sequence ID" value="ABL78833"/>
        <property type="gene ID" value="Tpen_1436"/>
    </dbReference>
    <dbReference type="GeneID" id="4601366"/>
    <dbReference type="KEGG" id="tpe:Tpen_1436"/>
    <dbReference type="eggNOG" id="arCOG00729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_5_0_2"/>
    <dbReference type="OMA" id="MVRTEMI"/>
    <dbReference type="OrthoDB" id="116013at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14719" checksum="8D2CA1E08BD9209F" modified="2007-02-06" version="1">MERRFLLDASSVVQALKLGNLRVIYGNYIQWLTVYEVVNALWKEALLAGSISVEEASNLVEVFAETVKLVEVLSPHPYEAEILETAAKLGLTAYDASYVVLAIRNGLSLVTEDRVLREKAKGVVKAVSLREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1S085</accession>
    <name>A1S085_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trimethylamine corrinoid protein</fullName>
            <ecNumber evidence="3">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753130.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1468"/>
    <dbReference type="EnsemblBacteria" id="ABL78865">
        <property type="protein sequence ID" value="ABL78865"/>
        <property type="gene ID" value="Tpen_1468"/>
    </dbReference>
    <dbReference type="GeneID" id="4601586"/>
    <dbReference type="KEGG" id="tpe:Tpen_1468"/>
    <dbReference type="eggNOG" id="arCOG02028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082102_2_0_2"/>
    <dbReference type="OMA" id="WADEIKA"/>
    <dbReference type="OrthoDB" id="95903at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="218" mass="24183" checksum="C9E4389BB7EC66F1" modified="2007-02-06" version="1">MAGDVGELREKLFQAVVEGDEAAAEEYTRRLVERGLGPREIVSEVLVPAMRRVGELYEKGEYFIPELVMSAEAFRRSMEVLRPLIRGQGESPARWVAVFGTVRGDIHELGKNLAAAVFEAEGFHVVDLGVDVPPEKFAEAVEKYNARVVGMSALMTTTMLEQRNVIEELKKRGLRDKVIVIAGGAPVTEEWVREIGADVWGRDAFEAVKIVKRMLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D7</accession>
    <name>A1S0D7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1520"/>
    <dbReference type="EnsemblBacteria" id="ABL78917">
        <property type="protein sequence ID" value="ABL78917"/>
        <property type="gene ID" value="Tpen_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1520"/>
    <dbReference type="eggNOG" id="arCOG04331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119426_0_1_2"/>
    <dbReference type="OMA" id="VFATPAM"/>
    <dbReference type="OrthoDB" id="96482at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="133" mass="14934" checksum="0DDE45D129E04877" modified="2007-02-06" version="1">MVVEGEAFSRTYTVQREHLARHISLGDTGILSTPNLVAFMEEASRVFLDEKLGKDYTTVGVRIDVHHVAPALLGSQVEVRGRILRSDGRRVTLWIEAWSGKTLIGYAVHERAVVKREEYLERIRSMLSSRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E7</accession>
    <name>A1S0E7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SufBD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1531"/>
    <dbReference type="EnsemblBacteria" id="ABL78927">
        <property type="protein sequence ID" value="ABL78927"/>
        <property type="gene ID" value="Tpen_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1531"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OMA" id="SIQSYPT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="406" mass="43561" checksum="E3C5E4A438A13B56" modified="2007-02-06" version="1">MRLMERVEAARKALSKPSPYGPDLDLSSFRVAAPGYSAGEPPRAVSSSVKERVGIDVSRASYVQVGETIFARVLAERLFREYGVVVKPLSKALKEDGPAARVAWSLIDPATDKYTAYAYLYGGEAGYYVYVPPGVKVDVPIYTCLSLFTGEEVQFAHNVVYLDEGAEAVVTTGCLVPHGVKGGLHVGLSEFFVGPGARLVFTMLHAWGEGTHVRPRTAVRVEEGGEYVSYYAVYSPVASLQTYPRVYLYRRASAKLTSVVAGTGPGVYDVGGGAVLLGEGSSAELVSRVLGSKGSTIVSRGSVEAEANDVKGHIECLGVMLDPSSTIEAVPVLKSRVERAELTHEAAIGMLSGEKIEYLMARGFSEEEARSILLRGYLTAETPGLPESVKGEIERVIEYVVRHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0F5</accession>
    <name>A1S0F5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753200.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1539"/>
    <dbReference type="EnsemblBacteria" id="ABL78935">
        <property type="protein sequence ID" value="ABL78935"/>
        <property type="gene ID" value="Tpen_1539"/>
    </dbReference>
    <dbReference type="GeneID" id="4600381"/>
    <dbReference type="KEGG" id="tpe:Tpen_1539"/>
    <dbReference type="eggNOG" id="arCOG05346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579535_0_0_2"/>
    <dbReference type="OMA" id="ESGGHWK"/>
    <dbReference type="OrthoDB" id="41931at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="484" mass="55818" checksum="14922C3F66BA19D5" modified="2007-02-06" version="1">MDLKCFDKITVGPVKVKGRRTSVRYVLEFDGLRKEYELVNVYPEDLDPRVLEEASSMAGIVPAVNYALFADEIRLDVKLHSLDLRFFEDMARVTAGDIFVNRIVARTGLIKEEYLPDPESVTPEDAEPRATVVAENVDDSTYLEAEPDYSKCGVMSSGGKESLFAYGLLREAGCEVYPFFLNEAGRHWWTALTAYRELSRRDPNTRRVWSNVDRLFAFIEKNMKIVVPNYWRKNREIYPVRLFWYAHYILSFLPLALKYGVGNIVMGNEFDDPSGLTFEYKGIRHYYATYDQSLDFDVYMTRYFEERGLGIKQWSPLRPVTPITILRILFDRYPDLAPLVTSCHSTHVENGVVKPCGTCYKCNGVLLMLLAVGADPRLLRYDERHVETLPERLSKGLVRLEPSLVKHSLYLVASRGLWRLPGAEPVWHVEMIHFDGINSTPDFIPHRDLRLRVLSIYEKYTRGYAKLENGQWVQVDPESIPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G7</accession>
    <name>A1S0G7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753212.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1551"/>
    <dbReference type="EnsemblBacteria" id="ABL78947">
        <property type="protein sequence ID" value="ABL78947"/>
        <property type="gene ID" value="Tpen_1551"/>
    </dbReference>
    <dbReference type="GeneID" id="4600900"/>
    <dbReference type="KEGG" id="tpe:Tpen_1551"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_1_0_2"/>
    <dbReference type="OrthoDB" id="65016at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="118"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="342" mass="38453" checksum="07770F08AF06E89F" modified="2007-02-06" version="1">MSSDSLVEMFRVLGAGRPEAEIYQALLKYGPSTLRELSDKVDMVGSQLHQYLKRLVRLGLVEVSRGKPSIYRAVSVETFDAIYRSRVESLRKNALERLKSISAQAHPASREYGVYVLRSWRAFRIRGLEYIRSAKCDVIVCGDSSFVKPYWEELRKKEEEGVNVFVILYELPGIPVREDEVVVRKARKAVSGDMMVVVDSRVALVAQRRLGPGERPEYGLSVEEPVLIDYLEQDFFNRWLRGSVIRDEPVRLPSCFTVNRLALIEAQRLLSEGRRLSLTAYGRYTGSRGEAIVEGIVRDAVVDQATGVAHFVVDTRAGSIRIGGPDAVVEEFAASRIELRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H1</accession>
    <name>A1S0H1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1555"/>
    <dbReference type="EnsemblBacteria" id="ABL78951">
        <property type="protein sequence ID" value="ABL78951"/>
        <property type="gene ID" value="Tpen_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1555"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_2_1_2"/>
    <dbReference type="OMA" id="YAADFKL"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="357"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="561" mass="60569" checksum="7413B721C8DF9CAB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H4</accession>
    <name>A1S0H4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fucose isomerase and related proteins-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753219.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1559"/>
    <dbReference type="EnsemblBacteria" id="ABL78954">
        <property type="protein sequence ID" value="ABL78954"/>
        <property type="gene ID" value="Tpen_1559"/>
    </dbReference>
    <dbReference type="GeneID" id="4600908"/>
    <dbReference type="KEGG" id="tpe:Tpen_1559"/>
    <dbReference type="eggNOG" id="arCOG01772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055583_0_0_2"/>
    <dbReference type="OrthoDB" id="76035at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="451" mass="51212" checksum="C3152A5ED1142219" modified="2007-02-06" version="1">MVELTVKPVLAYSVYERREATSWRAWGGIADEESAEEERRRIKAELKNLEQRAGFPLKFLPVGMVKSYGDVDRLEKADVYLLYAAGGDEGLLIGVAYRGPTVVFLRHRSGPLYLWYEIIDARLIRRYNDRIGQVWLDYDDVVVDDYEELLRRLRALYALKNTLGARVVAVGGASGWGIGGKAVELARARWHLDIVEVSYAELAERIKKAMGDERCLEEAKRMAKEYLSEEGVRLETREEFVVNAFVLYLVFKQLLEEHEARIITVNECMTTIMPIAKTTACLALSLLNDEGYLALCESDFVAIPAAILLHYASGKPVFLADPTLPHDGIVTVAHCTAPRLMDGRSREPARILTHFESDYGAAPKVEFRKGQVVTVLIPDFEEKTWVGFRGKIAEAPFLPICRSQAEIEIEGDWRRLLRELRGFHWLIVYGDYLREVSYALKKVGMEFVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I7</accession>
    <name>A1S0I7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753232.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1572"/>
    <dbReference type="EnsemblBacteria" id="ABL78967">
        <property type="protein sequence ID" value="ABL78967"/>
        <property type="gene ID" value="Tpen_1572"/>
    </dbReference>
    <dbReference type="GeneID" id="4600558"/>
    <dbReference type="KEGG" id="tpe:Tpen_1572"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_2"/>
    <dbReference type="OMA" id="PHADYVF"/>
    <dbReference type="OrthoDB" id="33242at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="141"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="531" mass="59608" checksum="E6E86D575BE10AC2" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K8</accession>
    <name>A1S0K8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Daunorubicin resistance ABC transporter, inner membrane subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753253.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1593"/>
    <dbReference type="EnsemblBacteria" id="ABL78988">
        <property type="protein sequence ID" value="ABL78988"/>
        <property type="gene ID" value="Tpen_1593"/>
    </dbReference>
    <dbReference type="GeneID" id="4600557"/>
    <dbReference type="KEGG" id="tpe:Tpen_1593"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OMA" id="HSLPPFW"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005942">
        <property type="entry name" value="Daunbcin-R_ABC-transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01247">
        <property type="entry name" value="drrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="255" mass="27755" checksum="F257461D0196B932" modified="2007-02-06" version="1">MRGLATMVYRQVKRFVNARSRLVMSVVQPVTWLVFFGMGWSRAFSFPGARAMFGGLDYLSYLASGMVAMTIIMGSFMSGISVIWDKQFGFLKETLVAPASRAEIIIGRALGDSLVVVFQSLIIMALMFLVAPGLNPYGVLPAVGYGLLLSLGFASIGIALSTKITSMEGFQMIVNLVTMPLLFLSGIFYPINTMPDWMKVLAYLDPATYAVDGMRYCLTGVSSIDPRVDVGLLVALTSVFLVVAAKSFEKTTIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0M0</accession>
    <name>A1S0M0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal-5'-phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1605"/>
    <dbReference type="EnsemblBacteria" id="ABL79000">
        <property type="protein sequence ID" value="ABL79000"/>
        <property type="gene ID" value="Tpen_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1605"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_1_2"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="OrthoDB" id="47519at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="2">
        <location>
            <begin position="89"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="382" mass="42330" checksum="3E67BB00E2BDC5BA" modified="2007-02-06" version="1">MDARFRGDEHLRRVLEVASRILREGRVKCLSGRPEDALVEEALAMLGCRVPRCGEAPAECSLEELGFYEDVSPSTLRVFNSTEELLYKNWPTPLVRLNSLGDGKVRAWAKLEFFNPFSMSVKDRIGWYMVKKLLEKHPGASLALYEATSTNTGMALAAMGAIKGFRVKLFLPETIQKASDTLLSVMGAEVRRVPKSLTVEFIDDVEHLAKEEGGVHLNQFENDANFGVHLRYTAKELDLQVRSAKLNLRGIVGGLGTSGHLSALSLYFKSRYSDVKIYGVQPAPGTVIPGIRRVETGMKWVHYVSVDKVVDVTPEEAVAHAVKVARREGILVGLSSGAVTAAFEALYSGGELPEGDYVLVYPDHGFKYVEQFSKYLPIIHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P1</accession>
    <name>A1S0P1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753286.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1626"/>
    <dbReference type="EnsemblBacteria" id="ABL79021">
        <property type="protein sequence ID" value="ABL79021"/>
        <property type="gene ID" value="Tpen_1626"/>
    </dbReference>
    <dbReference type="GeneID" id="4601029"/>
    <dbReference type="KEGG" id="tpe:Tpen_1626"/>
    <dbReference type="eggNOG" id="arCOG04394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127515_4_1_2"/>
    <dbReference type="OMA" id="GWAYIRP"/>
    <dbReference type="OrthoDB" id="121002at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="110" mass="12065" checksum="195DA3CAE933E5CC" modified="2007-02-06" version="1">MPLKVVVQVSDLNSVPQALKSCRNLLSEVPDAVVEIVFHQTAINALVKGKGFDDEIRGFVERGVVIAACRNSMRDRGIRSEDLVDGVTVVNSGVAEIVKKESEGWLYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R4</accession>
    <name>A1S0R4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phosphofructokinase / cytidine kinase / inosine-guanosine kinase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
            <ecNumber evidence="6">2.7.1.11</ecNumber>
            <ecNumber evidence="6">2.7.1.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EC" id="2.7.1.11" evidence="6"/>
    <dbReference type="EC" id="2.7.1.73" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753309.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1649"/>
    <dbReference type="EnsemblBacteria" id="ABL79044">
        <property type="protein sequence ID" value="ABL79044"/>
        <property type="gene ID" value="Tpen_1649"/>
    </dbReference>
    <dbReference type="GeneID" id="4601662"/>
    <dbReference type="KEGG" id="tpe:Tpen_1649"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_2"/>
    <dbReference type="OMA" id="AIVKQGP"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106366">
        <property type="term" value="F:guanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008906">
        <property type="term" value="F:inosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="308" mass="33075" checksum="0A79288A48F20516" modified="2007-02-06" version="1">MAFYDVVTLGHILLDLRFCVDAFATPDREGVIKSQSHGVGGSAANVAIGVRRLGGRSAVIGKVGFDDFGKNALEDLVREGVDISNVRIDALNGKTGFTIVIIDSQGQIVMYGDKGVAESLQPEEVNLKILKETGHLHIASLRVDTSAFVAKAAKELGVRVSWDPGRRQARMGIEALKPIVRLADIVLPNEIEVKAIAGVEDVKEAANVLLGEGAGLVIVKRGSRGVYVVSKDEEFEVPAYRPETVVDTTGAGDAFAAGLLMGLKRFDLRDAVRFATVVAGLKVTRLGSHEIPTWSEAMEVFEKVKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S2</accession>
    <name>A1S0S2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753317.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1657"/>
    <dbReference type="EnsemblBacteria" id="ABL79052">
        <property type="protein sequence ID" value="ABL79052"/>
        <property type="gene ID" value="Tpen_1657"/>
    </dbReference>
    <dbReference type="GeneID" id="4601734"/>
    <dbReference type="KEGG" id="tpe:Tpen_1657"/>
    <dbReference type="eggNOG" id="arCOG05654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243082_0_0_2"/>
    <dbReference type="OrthoDB" id="108297at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="220" mass="25457" checksum="A88D6FD557CD0470" modified="2007-02-06" version="1">MPVVLRGPRLRLARLKLSEKLLDLGEEIRGVYVPYPREMERVVNLYARGEVGWDRVVEEARRGMPEFYRGWLWVEEPLIRSLRVLGARVACYGDKLEGLYRSAGEFLSALLRVRVTGEVRLEEWRKLLSRSEVPVREGYVTVSSFSVPGATNVDVWGLPYPPTDEPDVGSEGWVRELVEYVFDYLVTSRNVDEAYVKWLRERRGVRARELEEMLSILPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S9</accession>
    <name>A1S0S9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753324.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1664"/>
    <dbReference type="EnsemblBacteria" id="ABL79059">
        <property type="protein sequence ID" value="ABL79059"/>
        <property type="gene ID" value="Tpen_1664"/>
    </dbReference>
    <dbReference type="GeneID" id="4601246"/>
    <dbReference type="KEGG" id="tpe:Tpen_1664"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="ARFRHFS"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="403" mass="45040" checksum="FCEB1C3AEC304EF9" modified="2007-02-06" version="1">MPKPTLVFSPLAEQLEPEGAFVYLDLAAEARRKGIDVISFGIGQPDFQPPREALEAIKEALDRGYTRYISPLGIPELREEIARYVGEKYGVDVKPSEVAVTVGAKAALFMTISLLTRPGDEVVVQDPAFPTYECVIRYAGGRPVFVRLAEERGFRLSAEDVERTVEGLHRVRGIVVNSPHNPTGSALEEKDVEALLELARRKGMFVISDEIYEDYVYEGKHASFLQAPDWRDYVVYVSGFSKTWAMTGLRLGYVVAREEVIRALEVFATNMYSCPPAPLQYGALKALQLGTGWFKPLLEEYRRRRDAAFEELSKIPGVSTVKSRGAFYLFPNFKEVLRATGLRSVDELAKRLLFEAGVVLLPGTAFPLRGGDGYMRVSYVLPVEKIREGFGRVREWVEKNAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U9</accession>
    <name>A1S0U9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753344.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1684"/>
    <dbReference type="EnsemblBacteria" id="ABL79079">
        <property type="protein sequence ID" value="ABL79079"/>
        <property type="gene ID" value="Tpen_1684"/>
    </dbReference>
    <dbReference type="GeneID" id="4600572"/>
    <dbReference type="KEGG" id="tpe:Tpen_1684"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044569_0_0_2"/>
    <dbReference type="OMA" id="VHIRMEN"/>
    <dbReference type="OrthoDB" id="110591at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="297"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="450" mass="48945" checksum="487F651055126181" modified="2007-02-06" version="1">MPGGGSKLRLVTTSLLVTLLILSLRLAVYALTNSLAVLADAFHSLVDILGNVFAVAAVAVSSKGPDADHSYGHEKAESLGTLFVAGLLTVIFAFIVYESLQRALAPSYSVAFTAWSSLLLAFTMSMDMWRARALSRGARLYRSTVLEADALHYTSDFYATGTILALSVVGTLYKGPYLKYLDMAVSVAIAGYFAYSSLRLAKTAVDELMDRTPTEVVALFREVASSRGLPVERVRARKAGPRVFLDAVARIPPGMTLEEAHRLVDEVEEELRGRAGVDVDVTIHMEPQDEVAATIARRVEEAARREGVVRVHGLELARGEGGVHVRFHVEAKPDVSVEEAKRIADELKREVESTPGVSSVVVHVEPAAKSEEDVRKAVERVLSREGLRGKLEVADVKVVKTEGKTLVDIVCKVPRGESIEEAHRSVGRLEGVLREELGEKYLVTVCLEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V0</accession>
    <name>A1S0V0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753345.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1685"/>
    <dbReference type="EnsemblBacteria" id="ABL79080">
        <property type="protein sequence ID" value="ABL79080"/>
        <property type="gene ID" value="Tpen_1685"/>
    </dbReference>
    <dbReference type="GeneID" id="4600573"/>
    <dbReference type="KEGG" id="tpe:Tpen_1685"/>
    <dbReference type="eggNOG" id="arCOG01426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_0_0_2"/>
    <dbReference type="OMA" id="NKGFARH"/>
    <dbReference type="OrthoDB" id="137511at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="386" mass="45347" checksum="24305F3FFA89900A" modified="2007-02-06" version="1">MGVRAEFLRLLEEDVEFRYAVAGYLGVLEVLRRLDSLAEEMKRLREEMHAGFAKHGEILERLEKILEKHEEALRRHDEELIRLREDMNKGFARHDEQLAKLREDMNSGFARHDEASRRHEEQLVKLREDFNKLREDMNKGFARHDEALKRHEEELVKLREDMNAGFARQDKELTRLREDMNAGFARHDELFRRHEEEMKGLREDMNKGFARHDEALRRHEEELVKLREDMNKGFARHDEALRRHEEILEKHSEELAKLRSAMIAGFGELSKFAGMTFEEFVRKFLTAYLREAGEVPEGSELRREVVEGEEIDLFLEEPLIVGEVTAHAESLEELEKLVRKAELVKAKYGKEPRKILVILTAPRDLAEKLEKIAGEKGVELIIGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V7</accession>
    <name>A1S0V7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753352.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1692"/>
    <dbReference type="EnsemblBacteria" id="ABL79087">
        <property type="protein sequence ID" value="ABL79087"/>
        <property type="gene ID" value="Tpen_1692"/>
    </dbReference>
    <dbReference type="GeneID" id="4601015"/>
    <dbReference type="KEGG" id="tpe:Tpen_1692"/>
    <dbReference type="eggNOG" id="arCOG02106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_1_2"/>
    <dbReference type="OMA" id="MNTTNTH"/>
    <dbReference type="OrthoDB" id="128059at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="139" mass="15581" checksum="2EF2ECE8C4A03CAD" modified="2007-02-06" version="1">MAFDEYRYYSGGKEEVLAKLREVLGSEEEVLLAVVFGSFVSLDSYRDVDLAVYTKRGDLGYLAALSARLELALGVPVDVVPLDEIPPRFRYSVLTKGVVVLERVPGLYESLLSRTLDELYYEAGCRRLCERIDAFSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0W1</accession>
    <name>A1S0W1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1696"/>
    <dbReference type="EnsemblBacteria" id="ABL79091">
        <property type="protein sequence ID" value="ABL79091"/>
        <property type="gene ID" value="Tpen_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1696"/>
    <dbReference type="eggNOG" id="arCOG03721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115256_0_0_2"/>
    <dbReference type="OMA" id="GRWIVID"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="162" mass="18536" checksum="86E55C87EF8D490D" modified="2007-02-06" version="1">MVTISRGFAEEAERRGVDLEGALPSRALVDPVEVAGARIDFAEEMLREAEEYVAKGNVVQASEKIYKAVEECVKALAERFNVKQLEEVRRRGRWDAWLLGQASTDLSRILGEDRIRFAWATAYDVHVWGFHEAKYRLEDVESALPIARWLLEYARKVVQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X8</accession>
    <name>A1S0X8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD_sub_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1713"/>
    <dbReference type="EnsemblBacteria" id="ABL79108">
        <property type="protein sequence ID" value="ABL79108"/>
        <property type="gene ID" value="Tpen_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1713"/>
    <dbReference type="eggNOG" id="arCOG01367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379579_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="94" mass="10802" checksum="78EC32E14614A0CF" modified="2007-02-06" version="1">MVLSCCLRICSLAPWSSWCKYYTCKRMSRYEFAVRLAERLGYSADLVDAVSAAEMKGWVARRPRDSSLDTSRARGILRTRFYDTGLALDMFAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y1</accession>
    <name>A1S0Y1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753376.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1716"/>
    <dbReference type="EnsemblBacteria" id="ABL79111">
        <property type="protein sequence ID" value="ABL79111"/>
        <property type="gene ID" value="Tpen_1716"/>
    </dbReference>
    <dbReference type="GeneID" id="4601741"/>
    <dbReference type="KEGG" id="tpe:Tpen_1716"/>
    <dbReference type="eggNOG" id="arCOG01401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014192_0_0_2"/>
    <dbReference type="OrthoDB" id="57938at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="105"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="274" mass="30341" checksum="C034060526D31F93" modified="2007-02-06" version="1">MKRRLGLVAGRVFLWMRIFRSFRGLTFRSAVNIPLSAAVDLLASLVTTPSNPRMLFSGFYLVKELGVVVFVRGGTEDLYYLLPGREGPVDEFIRSALSPGDVFVDVGANVGYYTLLGVLRGARVVAMEPVPQTVAVLKANLRLNGFSGVIVVDKCAWSTRGRVTLFVPSGRYYGLSSAYHDRGVKGSLVGVEAVRLDDVLRGFDRIRLVKLDVEGAEYDVLKGMESVLERVDFIVVEVSRRAKDIICLLKSHGFKVRRMGFTTYVLAQRISSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y4</accession>
    <name>A1S0Y4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Tpen_1719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1719"/>
    <dbReference type="EnsemblBacteria" id="ABL79114">
        <property type="protein sequence ID" value="ABL79114"/>
        <property type="gene ID" value="Tpen_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1719"/>
    <dbReference type="eggNOG" id="arCOG00253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_2"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="12">
        <location>
            <begin position="325"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL79114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="447" mass="48858" checksum="A16096C5614A2FDB" modified="2007-02-06" version="1">MDRVAVIGLGYAGLPFAVALAHRGFKVVGVDTDEEKVELINKGVSPVYEPALNDYLKGVLERGLFKATTSVAKAIEESDVVFVFVGTPTKADGSLDLTQLENASEDIGRALKDEGGYKLIVVRSTVLPGTTEGVVKRIIEERSGKICGRDFGLCMNPEFLREGKALYDIFNPARIVIGEYDKRSGDILESVYRRFHGEKMPPVIRTSIVNAELIKYAANAFLAMKVSFINLIARIAQRLPRGDVIEVASGIGLDPRIGRDFLDAGLGFGGSCLPKDLRALIKLAKSLGVDAKLLEAILEVNETQIDEALELLRRALGDLRGKRIAVLGLAFKPGTDDVRESQSIKLVKRLAKEGAVLHAHDPLALDAAKRVLQGIGNVAFFSDVYECARRCDAIVVATDWGDYRNLCFERLGETMARRVVIDCRHIIDAVKASKAGFKYYGLGIYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S101</accession>
    <name>A1S101_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753396.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1736"/>
    <dbReference type="EnsemblBacteria" id="ABL79131">
        <property type="protein sequence ID" value="ABL79131"/>
        <property type="gene ID" value="Tpen_1736"/>
    </dbReference>
    <dbReference type="GeneID" id="4601761"/>
    <dbReference type="KEGG" id="tpe:Tpen_1736"/>
    <dbReference type="eggNOG" id="arCOG02112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971892_0_0_2"/>
    <dbReference type="OMA" id="CLNSAPP"/>
    <dbReference type="OrthoDB" id="112900at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="7">
        <location>
            <begin position="148"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="271" mass="30448" checksum="AD6BFA5C3FB9CECF" modified="2007-02-06" version="1">MIVKERLARALEYIGLLKELRRRASPEALAGDYVVRGAVERYLHLAIEAVIDAGMRLCSLLRLGKPESYRDVARILRGAGMLSAASAGKLELWVGLRNVLVHGYARIDYGKLAEALGEVEELENIVYEIARSTENRGVDPPKAGKDAETIARVLSNRSNVVFAYIFGSRAKGQARCRSDIDVAVYTRGEASWKHLVELKNELEDALGLDVDLVHLNEAPLTLAYEVVSTGVLVLDRDSEARAEYEVKVLKQFLDMKPRLEEYYEELFRQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S116</accession>
    <name>A1S116_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753411.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1751"/>
    <dbReference type="EnsemblBacteria" id="ABL79146">
        <property type="protein sequence ID" value="ABL79146"/>
        <property type="gene ID" value="Tpen_1751"/>
    </dbReference>
    <dbReference type="GeneID" id="4601776"/>
    <dbReference type="KEGG" id="tpe:Tpen_1751"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="VAQPGPW"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="302" mass="32644" checksum="3F279F316AB88234" modified="2007-02-06" version="1">MIEFKGVVKKYGGFAALRGLDMHIPRGVTAGLVGPNGSGKTTTIKLAVGLLKKSGGEVRVLGLDPWYDGVELRRRVGVLHEKPLYPQDVTVRRLLEHLAGLRGLPAQEAVRVARLAGIEGYMERSVSSLSRGYLQRLGIAIALMGEPELLLLDEPTANLDPSARFEILGMLENLKKDLGVTMVISSHVLPELEKVCDYAVVLSGGVAVAQGSLLELARRFMATLELRIETRSPRLAASRLILSEAFLSVEVSDGLVVARVPGEKLREAEAVVEDLRRSGLAESWSVTSRSLGEVYEAVSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S137</accession>
    <name>A1S137_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THUMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753432.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1772"/>
    <dbReference type="EnsemblBacteria" id="ABL79167">
        <property type="protein sequence ID" value="ABL79167"/>
        <property type="gene ID" value="Tpen_1772"/>
    </dbReference>
    <dbReference type="GeneID" id="4601949"/>
    <dbReference type="KEGG" id="tpe:Tpen_1772"/>
    <dbReference type="eggNOG" id="arCOG00056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_795999_0_0_2"/>
    <dbReference type="OMA" id="ESRYQIQ"/>
    <dbReference type="OrthoDB" id="27531at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd11718">
        <property type="entry name" value="THUMP_SPOUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041730">
        <property type="entry name" value="MJ0421-like_THUMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025849">
        <property type="entry name" value="SPOUT_MTase_fused_to_THUMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14419">
        <property type="entry name" value="SPOUT_MTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="369" mass="40141" checksum="6FCDBF968B1846F7" modified="2007-02-06" version="1">MGGSALIITCKLGFERVVASYVEELDPAAEVEATPQGFAGLVLVRPGNLKAEELARAVKERVPEAEKVFVADAECNASIEEIVRCAVGISAGISREESFAVRTVRRGSHGFTSLDVNVAVGSAVKEATGARVDLENPDKVIFVQILQDKAYLSLVPGSEFYKKMPSSKYPVYKVFRKLVVAHEPYLGPPDASYVMGTRIGREVQVFEVGKLYVTPVGAVDAYSLYSFLRGAFEGQRSRFELQKRSYGREVVKTEVYVQDMYQFARSRLGKPLIIFEPEGEPVSRVAGEVADFIIRKVFKEKEEVAIMVGAREGVPTGLFRFADFVLDVAPGVVISTEYALSSGLIALATILHEKLVEAASSGELGAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S163</accession>
    <name>A1S163_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753458.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1798"/>
    <dbReference type="EnsemblBacteria" id="ABL79193">
        <property type="protein sequence ID" value="ABL79193"/>
        <property type="gene ID" value="Tpen_1798"/>
    </dbReference>
    <dbReference type="GeneID" id="4601921"/>
    <dbReference type="KEGG" id="tpe:Tpen_1798"/>
    <dbReference type="eggNOG" id="arCOG02879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079270_1_0_2"/>
    <dbReference type="OMA" id="NFIVIGY"/>
    <dbReference type="OrthoDB" id="139287at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025098">
        <property type="entry name" value="DUF4013"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13197">
        <property type="entry name" value="DUF4013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="219" mass="23989" checksum="C907FB9B505D6F7A" modified="2007-02-06" version="1">MQKMDPGSIISKSIDFSGKLIKDPGNLLLLIVLSIVPIINFIVIGYFVYVVRHDLEEPPKLDTSKLGDYFVEGLKVFLASLIILVPVLILGVLAGLVAGLAYPLGAFPFYFHRAFVLALFIPVLFVALAIAFIAVPLLAIVMRTGDLSKILAFQEALSLIQSYGLVDYAVLFLVLVVVGFLPYYVHWLLGAILAPFIYAFTFKALSLLVNIKYPAKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S191</accession>
    <name>A1S191_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferases probably involved in cell wall biogenesis-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753486.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1826"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79221">
        <property type="protein sequence ID" value="ABL79221"/>
        <property type="gene ID" value="Tpen_1826"/>
    </dbReference>
    <dbReference type="GeneID" id="4602063"/>
    <dbReference type="KEGG" id="tpe:Tpen_1826"/>
    <dbReference type="eggNOG" id="arCOG01391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041759_1_0_2"/>
    <dbReference type="OMA" id="VEQEARW"/>
    <dbReference type="OrthoDB" id="93709at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="137"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="480" mass="52099" checksum="49685BEF841B52E9" modified="2007-02-06" version="1">MVSLLASIIVLLLIAVPLLLLLLYELVIFAAAYLRREDAPPVGGEAPQSLEVVMPVYSEPLDLVASVSKRDFEAFSRAPCFARLTILSDDSAEYVEALSRLVSDAPGVAVWRRRERRGGRTGALDDYFASSSSSHLMILDADAVVDPCVAEKLCRNTLSDGALVVPWEGYYAYRTRLAEAVKFFTDLGTEVLYELRSRAGFYVFPLGSGTVYPRKVVLDVGGWGDGIVQDDIWMGVKLALGGYRTRLLSGSRLKVLVPSTLGAFKKQQRRWSYGTSDVLRRSFLRVLKHGGLPLHVRLEMLAYMSLPALTIPPALAVAVLPFLGLLEPRVGLGGLLTALSLALAPFVVVVPLYLYLYSKLVRVGSSLKESLVNLGRFAAIIATLVPVLALASVRGLLGLSYSFEVTPKGKKEAAEKKEALPVYLSAWFSASLAVGIVMQNSVQVLLSLLFLASSAWAYFRADGPMPELQGRITATGGGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1A5</accession>
    <name>A1S1A5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751360.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1840"/>
    <dbReference type="EnsemblBacteria" id="ABL79235">
        <property type="protein sequence ID" value="ABL79235"/>
        <property type="gene ID" value="Tpen_1840"/>
    </dbReference>
    <dbReference type="GeneID" id="4600341"/>
    <dbReference type="KEGG" id="tpe:Tpen_1840"/>
    <dbReference type="HOGENOM" id="CLU_490608_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="555" mass="60190" checksum="7C46DD1C6BDA370B" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D4</accession>
    <name>A1S1D4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751389.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1869"/>
    <dbReference type="EnsemblBacteria" id="ABL79264">
        <property type="protein sequence ID" value="ABL79264"/>
        <property type="gene ID" value="Tpen_1869"/>
    </dbReference>
    <dbReference type="GeneID" id="4600350"/>
    <dbReference type="KEGG" id="tpe:Tpen_1869"/>
    <dbReference type="HOGENOM" id="CLU_1773303_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="146" mass="15065" checksum="68BFD78D418C5C1A" modified="2007-02-06" version="1">MEAEDFLAVAFVLALATALALGLFTEGVKAVSPAWAGGSSGGGGGGSQVSLGVVELEVEGYAPRSAIPPGVLLSAKPLNVVNATCRCPEDPETFKGGVKCICWVTVKEGCYPLYPTLCARTNVVCTGKKYRVWWVSGGWVIPTTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW31</accession>
    <name>A1RW31_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase, PA-phosphatase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751676.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77411">
        <property type="protein sequence ID" value="ABL77411"/>
        <property type="gene ID" value="Tpen_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="4602200"/>
    <dbReference type="KEGG" id="tpe:Tpen_0001"/>
    <dbReference type="eggNOG" id="arCOG03058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068892_2_0_2"/>
    <dbReference type="OMA" id="PIGYPGI"/>
    <dbReference type="OrthoDB" id="108205at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="283" mass="29927" checksum="A6C6B53E0CC6095A" modified="2007-02-06" version="1">MARSKLDYLFAAVSVLLLVSPLIAYLTGNWVGFWRLATNLGDEPAYVALAVVLYFLVDQGLGFSVLLALSTTAWLNVVVKNTLRLPRPPRELWLANAEGYGFPSGHSQTSTTFWSSLSLKTRRLGVVVLGVAVVAIVGASRIMLNVHYPWDVAGGIALGLAVSYASYYLFDRLPGKASLSSAVLAVYGLAVGGLYLVVADATIARIGGLIVGLSVYPLVSEKVSLAGKPLAWRAVLAAVALVVAMLLTTVAKAQPVPVQFIAYLATGATVVSLPLLLKRAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW37</accession>
    <name>A1RW37_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751682.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0007"/>
    <dbReference type="EnsemblBacteria" id="ABL77417">
        <property type="protein sequence ID" value="ABL77417"/>
        <property type="gene ID" value="Tpen_0007"/>
    </dbReference>
    <dbReference type="GeneID" id="4601489"/>
    <dbReference type="KEGG" id="tpe:Tpen_0007"/>
    <dbReference type="eggNOG" id="arCOG02250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_0_2"/>
    <dbReference type="OMA" id="PYKIAYA"/>
    <dbReference type="OrthoDB" id="71426at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="258" mass="28498" checksum="1B535A93363AF1CE" modified="2007-02-06" version="1">MLSGLYVERKSFFHSLDPRVKLLWATLVLAASIATQFNGLKSFPVFVSAIAALTLSGIGAGLAAVLIFNSLVFLLITTLVWAGMYSGHGSPVFVLGFLRITDVGLLVASGKFFLIMSPVFAFITFFVTTKPYHVAWTLEKMGMPSKVSTAFVIAVSLLPTMVKATRDVIDIQKLRGLALDRGSVLDRLRNYIPIIVPVISRLLSDVWDLSLVLASRYVGYSKRRTYLLEPRWSSRDTVFALLSLVFYGVIIAWGLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW40</accession>
    <name>A1RW40_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Adenylate kinase</fullName>
            <shortName evidence="5">AK</shortName>
            <ecNumber evidence="5 7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adk</name>
        <name evidence="9" type="ordered locus">Tpen_0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5 7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0010"/>
    <dbReference type="EnsemblBacteria" id="ABL77420">
        <property type="protein sequence ID" value="ABL77420"/>
        <property type="gene ID" value="Tpen_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0010"/>
    <dbReference type="eggNOG" id="arCOG01046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_2"/>
    <dbReference type="OrthoDB" id="55175at2157"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="8">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="5">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="219" mass="24319" checksum="4A3B9BC65700D5F9" modified="2007-02-06" version="1">MQTIRVSILGPPGAGKGTYASEVARFFGVPHVSTGELLRQEIRKGSELGRRVATYVSRGLLVPDDVVNELVGSRLSQGDCAKGFVLDGYPRTLQQALFLEKHYPLDKAVLLSVSLKVAVERLSGRLYCPNCGETYHVSWKPPRKPGVCDNCGSRLVRRRDDDPEVVEARFREYWRLTLPVVDFYREKGKLLEFDANGDSRELAPRLVSILAGALAKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW45</accession>
    <name>A1RW45_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751690.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0015"/>
    <dbReference type="EnsemblBacteria" id="ABL77425">
        <property type="protein sequence ID" value="ABL77425"/>
        <property type="gene ID" value="Tpen_0015"/>
    </dbReference>
    <dbReference type="GeneID" id="4601715"/>
    <dbReference type="KEGG" id="tpe:Tpen_0015"/>
    <dbReference type="eggNOG" id="arCOG02998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079541_0_0_2"/>
    <dbReference type="OrthoDB" id="136489at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="118" mass="13606" checksum="163176063463F5B7" modified="2007-02-06" version="1">MKVLDARLYGERWTVAYRENDKWQVGIYIPENASLREVTVLEKHDRPELFVLLEGEITLVVSEDGSELREVKMEPGKLYVVDEWHNAYRPGGRRGVALVVEAPGVETEYMEVSPRCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW46</accession>
    <name>A1RW46_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751691.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0016"/>
    <dbReference type="EnsemblBacteria" id="ABL77426">
        <property type="protein sequence ID" value="ABL77426"/>
        <property type="gene ID" value="Tpen_0016"/>
    </dbReference>
    <dbReference type="GeneID" id="4601713"/>
    <dbReference type="KEGG" id="tpe:Tpen_0016"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088287_0_0_2"/>
    <dbReference type="OrthoDB" id="96126at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="258" mass="27880" checksum="02B01DCF2CB2FF39" modified="2007-02-06" version="1">MKVAVVALPEAREPEAALQWLKGYLGAIGVEPSLVRANVSLEEVAAVIAEQDAVIVVGAAGNRKAVEVIGNALGLKLEVNKEALELVTGYYMDRVDIPGNVEELAITPEFSYVIPNERGPVPAFVAFSLTDDRFVAATPPGFEETIETFEAGIQDFFREKTGKKYSVTFSMDVECGVEEAESIVSEVNSGVKGVFARLDARFYTGKGLPLTFTAYSETPEGLSDAMERVEELVKKLAAEKGLRLVEKEKAGGVKEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW72</accession>
    <name>A1RW72_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751717.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0042"/>
    <dbReference type="EnsemblBacteria" id="ABL77452">
        <property type="protein sequence ID" value="ABL77452"/>
        <property type="gene ID" value="Tpen_0042"/>
    </dbReference>
    <dbReference type="GeneID" id="4600983"/>
    <dbReference type="KEGG" id="tpe:Tpen_0042"/>
    <dbReference type="eggNOG" id="arCOG03413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825435_0_0_2"/>
    <dbReference type="OrthoDB" id="86347at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="337" mass="37566" checksum="413C663D58315D28" modified="2007-02-06" version="1">MARFRDLGGGLYWSSCPDDDLLETLAKRGLGLVVDLTEEECQYSVPSGVDRVNYPIPDFSFRAFEGVLVKAVLPSLRYLESGRGVLVHCYGGIGRSGSTVAMILALRDGSSFEGVLRRLRRLGYENETLSQALAVRWFYRVKGLLDVGFLERLLLELEDEGYWKFLDHASSVAGVALDVLESLSGIYGFDRRDYVNAYLAGLLHDVGRVLGPEERHHEVGAEWVKRNPLLRGVCDVDIVSFAVYHHRRKTRLTEDPRIERLGVKAGVIAAAVRLGDAFKNAYAGEGTYVGTELRGSRLVIVINGHLNKGVDKRRIEEKAKALEELDRSIAVEVEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW73</accession>
    <name>A1RW73_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62, modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751718.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0043"/>
    <dbReference type="EnsemblBacteria" id="ABL77453">
        <property type="protein sequence ID" value="ABL77453"/>
        <property type="gene ID" value="Tpen_0043"/>
    </dbReference>
    <dbReference type="GeneID" id="4600578"/>
    <dbReference type="KEGG" id="tpe:Tpen_0043"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="OrthoDB" id="22382at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="113"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="231"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="463" mass="49712" checksum="BA4E89D8A8CB2E6C" modified="2007-02-06" version="1">MHEDDVKLVLGKAGSLGVQFAEVRFEESTREIISYVNGRIASMSNQRLRGVGVRVLYNGNFGFASTFDLSRDGLLSALEEAFKAARALGPGNKRLAEVEASKRRYSIEGVKRHPARAELAEKLDLVKRAYETLKSGGASSAVVRYGAYYGRVEVYTSEGLEVSSERLVTGVSATAVLRENGRVGDGTETYGASKGLEAFTGDRAPEAIAEKALEVARAALNASRPPAGLQTVITRPELTGVFAHESFGHLTEGDGVFAGSSPLVGRLGEVLASEQVTIVDSGFDERGGYVLLADDEGVPTERTILVEKGVLKGYLHSRESAALTGMKPTGNGRAQSFAHDVIVRMRNTFFEAGDWTEEEIIRETRHGILLDKPAGGQVEEDGTFTFNARIGYIVENGELKQPVRDVVLAGNILEMLKYVDAAGKNVEISTSPFGGCGKWGQMVHVGDGGPTLRVSRLLVGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW91</accession>
    <name>A1RW91_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751736.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0061"/>
    <dbReference type="EnsemblBacteria" id="ABL77471">
        <property type="protein sequence ID" value="ABL77471"/>
        <property type="gene ID" value="Tpen_0061"/>
    </dbReference>
    <dbReference type="GeneID" id="4601780"/>
    <dbReference type="KEGG" id="tpe:Tpen_0061"/>
    <dbReference type="eggNOG" id="arCOG01400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084251_0_0_2"/>
    <dbReference type="OMA" id="YETHIIS"/>
    <dbReference type="OrthoDB" id="120669at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="79"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="259" mass="28953" checksum="5051A02687F06C3A" modified="2007-02-06" version="1">MPSRERAEKILFLLGELLYESQRVLSSSHAVLVFGAHRFVVPKGWADSSLRNLEHVFVKHDYDRIPGFTRVPRGSTVVDLGAYVGFFSVKVHSESPGARLVAVEANPQACRYLRHNLRMNGVRSEAYCLAVGESDGVGRLFVAEDPVNSSLLEEYSSSFSRVSGVARVAQLSLSSLWRRLDVGHASLLKVDVEGVEERVLRASRDVLTPGCVDRVVVEVHPPYSSPSRVVELLERGFHVATYYDYEAPFQVFVYGWAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RW96</accession>
    <name>A1RW96_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751741.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0066"/>
    <dbReference type="EnsemblBacteria" id="ABL77476">
        <property type="protein sequence ID" value="ABL77476"/>
        <property type="gene ID" value="Tpen_0066"/>
    </dbReference>
    <dbReference type="GeneID" id="4600888"/>
    <dbReference type="KEGG" id="tpe:Tpen_0066"/>
    <dbReference type="eggNOG" id="arCOG02252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_6_1_2"/>
    <dbReference type="OrthoDB" id="134852at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="238" mass="26556" checksum="E930F79ABFB2197F" modified="2007-02-06" version="1">MARLPSPKDFLSSLNPLTKLALFLVGIFQVALLGDPKYALLHLLLSSTLLALVRPKVGKAEFAAALSTLVGYTWVNTALYIYNYSMSPWDAARNALQLTARVAIIILYSMTFVATTTPKALTVALTEQLGVPYVYAFMSFVTLRMAPLIRRDLENMIAYRRIKGYFSWKAPHRYVASYAFPLLFLAVRRSITLALSMQARGFGKYAERTNLEKTRFRRGDLLFALAYLSAAAAPALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWA1</accession>
    <name>A1RWA1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751746.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0071"/>
    <dbReference type="EnsemblBacteria" id="ABL77481">
        <property type="protein sequence ID" value="ABL77481"/>
        <property type="gene ID" value="Tpen_0071"/>
    </dbReference>
    <dbReference type="GeneID" id="4601779"/>
    <dbReference type="KEGG" id="tpe:Tpen_0071"/>
    <dbReference type="eggNOG" id="arCOG01364">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478700_0_0_2"/>
    <dbReference type="OMA" id="HWLVHAH"/>
    <dbReference type="OrthoDB" id="90547at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026447">
        <property type="entry name" value="B12_SAM_Ta0216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00326">
        <property type="entry name" value="5''-pyrrole_methytransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04190">
        <property type="entry name" value="B12_SAM_Ta0216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="551" mass="63167" checksum="2D8E8AC02D5E2BCF" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWB4</accession>
    <name>A1RWB4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0084"/>
    <dbReference type="EnsemblBacteria" id="ABL77494">
        <property type="protein sequence ID" value="ABL77494"/>
        <property type="gene ID" value="Tpen_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0084"/>
    <dbReference type="eggNOG" id="arCOG15235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3210944_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="44" mass="5117" checksum="706B97D1D7EFF357" modified="2007-02-06" version="1">MEELTMEEFLRKLAGKRIRVKNVEAAPPSLILESMGKVYRVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI0</accession>
    <name>A1RWI0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0150"/>
    <dbReference type="EnsemblBacteria" id="ABL77560">
        <property type="protein sequence ID" value="ABL77560"/>
        <property type="gene ID" value="Tpen_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0150"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="EDCWFIA"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="167" mass="18522" checksum="C97EF7886B9BDF28" modified="2007-02-06" version="1">MHGFKVDGYNEAFLAEITVSTVVAREVRMDEKDLALIRELTENGRASLTELGRKLGITDVAVKKRLRKLERAGVIKKYTVEVDPSKLGYKSVALIGIDVEPEKILDVASKIASKDFAVKVYLTTGDHMIMVEAWARDNKHLTQIIGEIGSTEGVKRVCPAIVLEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWP8</accession>
    <name>A1RWP8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaetidylinositol phosphate synthase</fullName>
            <shortName evidence="1">AIP synthase</shortName>
            <ecNumber evidence="1">2.7.8.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:36823"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74004"/>
            <dbReference type="ChEBI" id="CHEBI:74006"/>
            <dbReference type="EC" id="2.7.8.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.39" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0218"/>
    <dbReference type="EnsemblBacteria" id="ABL77628">
        <property type="protein sequence ID" value="ABL77628"/>
        <property type="gene ID" value="Tpen_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0218"/>
    <dbReference type="eggNOG" id="arCOG00670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_1_2_2"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02242">
        <property type="entry name" value="AIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044270">
        <property type="entry name" value="AIP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="199" mass="21519" checksum="525E0FE7303AB9E1" modified="2007-02-06" version="1">MLTNIKQRVERAFSPLGDAIAATGLKPNHITVLGFALNASSVALLAWTGSLPSFLAVFTLASLMDVLDGYVARKTGRVSAFGAFLDSTLDRVSDTLTSFALMLVGVASAYETIFLVLGEYLVSYTRARAESLGVKMAGIGIAERAERLLLKFSVFFAILIGASIVARAVLWVLILVTYITVLQRVAHAYRSLTRATRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ2</accession>
    <name>A1RWQ2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="4" type="ordered locus">Tpen_0222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751897.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0222"/>
    <dbReference type="EnsemblBacteria" id="ABL77632">
        <property type="protein sequence ID" value="ABL77632"/>
        <property type="gene ID" value="Tpen_0222"/>
    </dbReference>
    <dbReference type="GeneID" id="4601212"/>
    <dbReference type="KEGG" id="tpe:Tpen_0222"/>
    <dbReference type="eggNOG" id="arCOG04288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OMA" id="MAHVAEW"/>
    <dbReference type="OrthoDB" id="73593at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="3">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="294" mass="32107" checksum="07A003D7126A3CF6" modified="2007-02-06" version="1">MSLQAVSVKSSPARARKAKLLEELSGYLKQYRYYMVASITGLPASVVKTSRSLLRSDGSLMKVVKNTIFLLALKNTGKYVEGIEEHLRGQNAVIFTNKNPFEILFFLDKQKIMREARAGDIATSEIVLPAGNTGIPPGPMISNFNKLGIPTRVQEGSIWIAKDTVVAKPGDVISPELAELLSKLGLKPIESKLQIKTIYLDGKVVSPKDVELDVSLWKNRLVSAHTEAYNLAFNAALPLPQVLPQLIAKAHIEALALASNAAYPAREALPQILAKAEAQAKALYERLKAVKPEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWT7</accession>
    <name>RS11_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps11</name>
        <name type="ordered locus">Tpen_0257</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWT7"/>
    <dbReference type="SMR" id="A1RWT7"/>
    <dbReference type="STRING" id="368408.Tpen_0257"/>
    <dbReference type="PRIDE" id="A1RWT7"/>
    <dbReference type="EnsemblBacteria" id="ABL77667">
        <property type="protein sequence ID" value="ABL77667"/>
        <property type="gene ID" value="Tpen_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0257"/>
    <dbReference type="eggNOG" id="arCOG04240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_2"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000294906" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="156" mass="16712" checksum="896268BF825D8DFA" modified="2007-02-06" version="1">MSEKEQKEVEAKESSGKAEERRETREKQVRGDVGIAWIYASYNNTIIHITDLSGAETIAFASGGMVAKADRDKPSPWAAMQAAARAAKIALDKGIRVVHVKIKAPGGYGPKTPGPGAGPAIRALVRAGLMVDRIEDVTPLPTDSIRKPGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWU0</accession>
    <name>A1RWU0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0260"/>
    <dbReference type="EnsemblBacteria" id="ABL77670">
        <property type="protein sequence ID" value="ABL77670"/>
        <property type="gene ID" value="Tpen_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0260"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="493" mass="55685" checksum="372A0166930F5EDF" modified="2007-02-06" version="1">MNEVVMKGDGAGEGVEERVREEVWRRAALSLYATRIKDKRRSRGKKKRGEIHYVGLFDAVTGINWDFTRFAAHALTVVPDEAYPRFYRFIDIDARKYLLLSDDNRPREGSAAVELRGRLQAIVDAGADGLRAERHGRHWRVYPPRENWYVVVSKPTSGWSVRIPLKGFWVESEFPRVLMNTPISVLRSLQRGWILTDVTPPHGRHSDVRFSTTQPWQLPATLAAFPSDNIRLGITAGILGSTRLSIEWGVSIYGYEEELGWASGLVGEVKRVEFRALVERCKALQGDPVALHTAFLGDGLRTLFLRIRELYFSIGNEIVYLPTESAVFNARAAVELASEYVAFVGKVTRCAKIRHWLYVAYGAPGRRGRRPGQKVVSYQELGFYVDIAGAMLNLSLVTVGDKYAYIYARMPFDSAPPGWYERAVKEGWTVNVVRSGGTLYYEIPQDSLFEHAGEDPELWEALYRFAVAKSEARPAAKKLVEELLRIKPAGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWW0</accession>
    <name>A1RWW0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo3</name>
        <name evidence="4" type="synonym">rpoD</name>
        <name evidence="6" type="ordered locus">Tpen_0280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="4">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0280"/>
    <dbReference type="EnsemblBacteria" id="ABL77690">
        <property type="protein sequence ID" value="ABL77690"/>
        <property type="gene ID" value="Tpen_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0280"/>
    <dbReference type="eggNOG" id="arCOG04241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_3_1_2"/>
    <dbReference type="OMA" id="ECLRHPE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="5">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="283" mass="31217" checksum="7662E99B1333E031" modified="2007-02-06" version="1">MLSKKQNRLVFMLRNTTPAFANALRRALISEVPILAIDEVIVTENTSALWDEMIAHRLALVPLKIDPETYDALRDLYEQGKDPQVIFSLEEEAGERPRTVLSGHLRFEGIEGAPLPPESAGIEPVSKNIPILKLGKGQKISLTAIARMGTGRQHAKWQPVGPVGYKYKPVVRILREDLPEDEALKIISTCPRRVFGYVDGKLTVINEMQCSLCRECEEKFPGIVEVDGDPSNIILTVESIGCLPPEKLLAVAADVLSKKLDNFLEKVQLAVSSTLTGKAPSEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY2</accession>
    <name>FEN_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flap endonuclease 1</fullName>
            <shortName evidence="2">FEN-1</shortName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fen</name>
        <name type="ordered locus">Tpen_0302</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751977.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWY2"/>
    <dbReference type="SMR" id="A1RWY2"/>
    <dbReference type="STRING" id="368408.Tpen_0302"/>
    <dbReference type="EnsemblBacteria" id="ABL77712">
        <property type="protein sequence ID" value="ABL77712"/>
        <property type="gene ID" value="Tpen_0302"/>
    </dbReference>
    <dbReference type="GeneID" id="4601125"/>
    <dbReference type="KEGG" id="tpe:Tpen_0302"/>
    <dbReference type="eggNOG" id="arCOG04050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="OrthoDB" id="41214at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000061334" description="Flap endonuclease 1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain">
        <location>
            <begin position="118"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="2">
        <location>
            <begin position="336"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <sequence length="346" mass="39575" checksum="00E7F92D87D7F88A" modified="2007-02-06" version="1">MGVDIKELVEPVAKEVELGFFSKKVIAIDAYNSLYQFLATIRQKDGTPLLDAQGNVTSHLNGLFYRTINYIELGIKPVYVFDGRPPELKQKELERRYQIKVEAEKKYREAIERGDLEEARIYAQQTSRLTAAMVHDAKLLLRYMGVPYVEAPSEGEAQAAYMVKKGDAWASGSQDFDSLLFGSPRLVRNLAITGKRKLPRKDVYVEVKPEIVELEELLRVHGITHQQLVVIGILVGTDYAPEGARGIGVKKALKLVKELKDPEKIFRSVEWSSDVPPEKILELFLHPEVTDSYELTWKEPDKEKVIELLVERHQFSMERVTNALDRLEKAVKTHFKQQSLESWFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWY7</accession>
    <name>A1RWY7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751982.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0308"/>
    <dbReference type="EnsemblBacteria" id="ABL77717">
        <property type="protein sequence ID" value="ABL77717"/>
        <property type="gene ID" value="Tpen_0308"/>
    </dbReference>
    <dbReference type="GeneID" id="4601711"/>
    <dbReference type="KEGG" id="tpe:Tpen_0308"/>
    <dbReference type="HOGENOM" id="CLU_2434024_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="10062" checksum="5148F96AA7134F7B" modified="2007-02-06" version="1">MKVVVKVREEQVDLDVDVDEPEYLLDASDKALRGLSRAVIELAITRDLAVLIDAVRRVAAEVSASKIECKFVEQASPDLDYELELECTLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX59</accession>
    <name>IF2B_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eif2b</name>
        <name type="ordered locus">Tpen_0380</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752054.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX59"/>
    <dbReference type="SMR" id="A1RX59"/>
    <dbReference type="STRING" id="368408.Tpen_0380"/>
    <dbReference type="EnsemblBacteria" id="ABL77789">
        <property type="protein sequence ID" value="ABL77789"/>
        <property type="gene ID" value="Tpen_0380"/>
    </dbReference>
    <dbReference type="GeneID" id="4602148"/>
    <dbReference type="KEGG" id="tpe:Tpen_0380"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_3_1_2"/>
    <dbReference type="OMA" id="GKPDTRL"/>
    <dbReference type="OrthoDB" id="96453at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000336760" description="Translation initiation factor 2 subunit beta">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <sequence length="141" mass="16234" checksum="1FEF71C9F51AD42F" modified="2007-02-06" version="1">MTQAFMSYEELLERAYSMLPRRRRRSTGERFVLPTFEVSKTGKKVYIHNFKDVAEKLNREPPVLLRFILKEIALPGVYENGTAVIHGEVSAQTLNKLLERFYNEYVKCPVCEAPDTILVKEKKLMYIKCTACGAVSPVKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX82</accession>
    <name>A1RX82_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752077.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL77812">
        <property type="protein sequence ID" value="ABL77812"/>
        <property type="gene ID" value="Tpen_0403"/>
    </dbReference>
    <dbReference type="GeneID" id="4601497"/>
    <dbReference type="KEGG" id="tpe:Tpen_0403"/>
    <dbReference type="HOGENOM" id="CLU_1954779_0_0_2"/>
    <dbReference type="OrthoDB" id="132020at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="126" mass="14242" checksum="9C35FDAD5D56B2A4" modified="2007-02-06" version="1">MPKTALYVLSGVSVDDLRSSIARLNATTRNFSLESVSGGEWVTARLTTAPLRDNCYSIRIRLSKKRGWLWGEEFVACIEEYGESVRLTVRRVKGVGRVGSDLIGAWIIEDTSRELPWLEVRHAELF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX88</accession>
    <name>IF5A_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">eIF5A</name>
        <name type="ordered locus">Tpen_0409</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752083.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RX88"/>
    <dbReference type="SMR" id="A1RX88"/>
    <dbReference type="STRING" id="368408.Tpen_0409"/>
    <dbReference type="EnsemblBacteria" id="ABL77818">
        <property type="protein sequence ID" value="ABL77818"/>
        <property type="gene ID" value="Tpen_0409"/>
    </dbReference>
    <dbReference type="GeneID" id="4601503"/>
    <dbReference type="KEGG" id="tpe:Tpen_0409"/>
    <dbReference type="eggNOG" id="arCOG04277">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_3_0_2"/>
    <dbReference type="OMA" id="QIMDMET"/>
    <dbReference type="OrthoDB" id="98221at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0385">Hypusine</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000093012" description="Translation initiation factor 5A">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <sequence length="132" mass="14589" checksum="0C85273481D1BC14" modified="2007-02-06" version="1">MSTRPEEAGNIKVGSFIVIDGEPCKVVEVEKSKTGKHGSAKARIVGIGFFDGGKRSIVVPTDARVEVPIIKKFTAQVVAFVGDNVQLMNLEDYSTFEIPMPQEEEIKSKLSEGVEVEVWEVMGRHKIMRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX91</accession>
    <name>A1RX91_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752086.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0412"/>
    <dbReference type="EnsemblBacteria" id="ABL77821">
        <property type="protein sequence ID" value="ABL77821"/>
        <property type="gene ID" value="Tpen_0412"/>
    </dbReference>
    <dbReference type="GeneID" id="4601506"/>
    <dbReference type="KEGG" id="tpe:Tpen_0412"/>
    <dbReference type="eggNOG" id="arCOG03199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_4_1_2"/>
    <dbReference type="OMA" id="DDILGWK"/>
    <dbReference type="OrthoDB" id="88899at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="341" mass="36121" checksum="97B043D35B134EB1" modified="2007-02-06" version="1">MAYPDYLVYGVASSILGYLVVRLSAPSLIRALFKAGLRRPDAHKPGNPLVAHSGGVILFLGFLLSFSLLIAFGGLGFSEKVKLLAVLATSALCFAVGLLDDKLVLKGVLKTFLTALSIIPILVVALTYPAAIDWGRPVVPIIGRMRMTVIYWVLFPISIAGSANVVNMLDVLNGIVPGTALVAFAALAVIGALSGDGLLLVIALVAVAILLAYYPFNAYPARVFNGDSGSLFIGGLLGAIAVVFHLEFVVLTLLLPHILNGFFVVVSFRGLREHREVKARPIRVENGILKASDDPKAPLTLTRLILSVGGPMTEKEVAKVYIAVEVVAAVLAVASYVLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXA3</accession>
    <name>A1RXA3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 1A</fullName>
            <shortName evidence="3">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif1a</name>
        <name evidence="6" type="ordered locus">Tpen_0424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752098.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0424"/>
    <dbReference type="EnsemblBacteria" id="ABL77833">
        <property type="protein sequence ID" value="ABL77833"/>
        <property type="gene ID" value="Tpen_0424"/>
    </dbReference>
    <dbReference type="GeneID" id="4602103"/>
    <dbReference type="KEGG" id="tpe:Tpen_0424"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OMA" id="ADITWRY"/>
    <dbReference type="OrthoDB" id="102432at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="105" mass="12073" checksum="E26CAF3DFC767BFF" modified="2007-02-06" version="1">MSSPNDESEALEFPLPDGQTTLLCVIQQLLGFDRARVFCSDGKVRLCRIPGKFKKRMWMKVGDVVLVAPWDFQPERGDIIYRYTSNELQKLEKKGLLKELKELLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-17" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF0</accession>
    <name>Y471_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-binding protein Tpen_0471</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_0471</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752145.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RXF0"/>
    <dbReference type="SMR" id="A1RXF0"/>
    <dbReference type="STRING" id="368408.Tpen_0471"/>
    <dbReference type="EnsemblBacteria" id="ABL77880">
        <property type="protein sequence ID" value="ABL77880"/>
        <property type="gene ID" value="Tpen_0471"/>
    </dbReference>
    <dbReference type="GeneID" id="4602030"/>
    <dbReference type="KEGG" id="tpe:Tpen_0471"/>
    <dbReference type="eggNOG" id="arCOG04179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_3_0_2"/>
    <dbReference type="OMA" id="KPQFGEQ"/>
    <dbReference type="OrthoDB" id="130316at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000284570" description="DNA-binding protein Tpen_0471">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <sequence length="116" mass="13722" checksum="7B2732DFE65262DC" modified="2007-02-06" version="1">MSYDEGGEELEEIKRRKLLEYQRALEAEKAKEEQKAREEAMRQEILRRILTPEARARLSNLKLVKPELVEALEIQLIQLAESRSVRVPIDDETLKQILARLYEAQRAREVKFRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF9</accession>
    <name>A1RXF9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0480"/>
    <dbReference type="EnsemblBacteria" id="ABL77889">
        <property type="protein sequence ID" value="ABL77889"/>
        <property type="gene ID" value="Tpen_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0480"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="75" mass="8354" checksum="E73B40E6E7EB5629" modified="2007-02-06" version="1">MSDPRVTVRTIGALSRLLASTLRRDELYEARLVEALDAIEEFLASVRSAPQVEEDEELARELEEGVEELRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI8</accession>
    <name>A1RXI8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KH, type 1, domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0512"/>
    <dbReference type="EnsemblBacteria" id="ABL77918">
        <property type="protein sequence ID" value="ABL77918"/>
        <property type="gene ID" value="Tpen_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0512"/>
    <dbReference type="eggNOG" id="arCOG04150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_3_0_2"/>
    <dbReference type="OMA" id="DPLAVWK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="197" mass="22072" checksum="53B5ACB4A830410C" modified="2007-02-06" version="1">MPEEGQGVSPRGKLPVPVEQSRIGYIIGKDGSNKRRLEETFNVKLDVDSATGVVYVEPGEGATPYNVFRAKKALEAISIGFTVDDALLLGDDAYDLEVIDLSEVSKRREDLSRIKARIIGTEGRFKKTLEDMTGARIVIGEKAVGIIGDFEQNKVVKEALERLIAGQSHQSVMKFLERMSFELKRRRTQLWERMQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK9</accession>
    <name>A1RXK9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752204.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0533"/>
    <dbReference type="EnsemblBacteria" id="ABL77939">
        <property type="protein sequence ID" value="ABL77939"/>
        <property type="gene ID" value="Tpen_0533"/>
    </dbReference>
    <dbReference type="GeneID" id="4601046"/>
    <dbReference type="KEGG" id="tpe:Tpen_0533"/>
    <dbReference type="HOGENOM" id="CLU_157724_0_0_2"/>
    <dbReference type="OrthoDB" id="130147at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="135" mass="14686" checksum="6D9B303FEB79EF85" modified="2007-02-06" version="1">MSETIEVVLERFGSKVALLELYESQIPLNFANISKLSQVITTAKRLGSLVLLSIPAQLRPEGTIMTSLKAGEVVVVPVARSLGVVITDVEALPLESYKAGIVKTGLENLRGLREGTILNAKFSLKQLEEPQRQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXN9</accession>
    <name>A1RXN9_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="7">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">aIF2-gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">eIF-2-gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eif2g</name>
        <name evidence="9" type="ordered locus">Tpen_0563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752234.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0563"/>
    <dbReference type="EnsemblBacteria" id="ABL77969">
        <property type="protein sequence ID" value="ABL77969"/>
        <property type="gene ID" value="Tpen_0563"/>
    </dbReference>
    <dbReference type="GeneID" id="4600606"/>
    <dbReference type="KEGG" id="tpe:Tpen_0563"/>
    <dbReference type="eggNOG" id="arCOG01563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="25592at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00119">
        <property type="entry name" value="eIF_2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="13"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL77969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="423" mass="46068" checksum="CBE9C13E557FDC1F" modified="2007-02-06" version="1">MSEDEFQEALKKQPLVNIGTSGHVDHGKTTLIEALTGVWASRHSEELKRGITLKIGYADTAIYKCPKCPPPQAYYTSATMPKDGKCKYCGSPLEFVRKVSFIDVPGHEMLMSIMLAGAALMDGALLVVDATKECPQPQTREHFTALSIIGVRNLVIVQNKVDVVSKERALESYNEIKKFIAGTWAENAPIVPVSALHKANIDALVWAIEEYIPTPRRDFSKPPRMFVIRSFDVNKPGTNAKDLVGGVLGGTIVQGRFEVGHEIEIRPGIKIKKDGQEVYEPVYTTITSLKTGDQPLEKAYPGGLVAVGTTLDPSVTKADNLIGNVVGYPGTLPPTLYDLEIEVNLLERVVGLDKPMKVEPVRAGEILMVNVGTALSIGAVTSVRDNVAHMKLKIPVVAETGTRVAISRQLAGKWRLIGYGFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW2</accession>
    <name>A1RXW2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0639"/>
    <dbReference type="EnsemblBacteria" id="ABL78042">
        <property type="protein sequence ID" value="ABL78042"/>
        <property type="gene ID" value="Tpen_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0639"/>
    <dbReference type="eggNOG" id="arCOG14980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140335_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="115" mass="12542" checksum="5E29792F6B12D9A3" modified="2007-02-06" version="1">MALRVSKRGIDFRVLAAALLAVILLIASGVFYVLSERPPFSLGVQLIYPSGGGQTVSEMIIVLFLYAMAIVGLLIIYDSTKYSPQRSAFYFTLVSGVAVVAVSLLLLLFIYTNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXZ4</accession>
    <name>A1RXZ4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752339.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0672"/>
    <dbReference type="EnsemblBacteria" id="ABL78074">
        <property type="protein sequence ID" value="ABL78074"/>
        <property type="gene ID" value="Tpen_0672"/>
    </dbReference>
    <dbReference type="GeneID" id="4601038"/>
    <dbReference type="KEGG" id="tpe:Tpen_0672"/>
    <dbReference type="HOGENOM" id="CLU_299106_0_0_2"/>
    <dbReference type="OrthoDB" id="133499at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110200" checksum="583FA64ABFB4A203" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY05</accession>
    <name>A1RY05_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752350.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0683"/>
    <dbReference type="EnsemblBacteria" id="ABL78085">
        <property type="protein sequence ID" value="ABL78085"/>
        <property type="gene ID" value="Tpen_0683"/>
    </dbReference>
    <dbReference type="GeneID" id="4601883"/>
    <dbReference type="KEGG" id="tpe:Tpen_0683"/>
    <dbReference type="eggNOG" id="arCOG04298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138382_0_0_2"/>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="OrthoDB" id="94911at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="163" mass="17830" checksum="03B8D5E781D238A5" modified="2007-02-06" version="1">MELKFEVVDVKLPSKSNVIIGQTHFIKSVEDIAEAVSTSVPGVKFGLAFNEASGDRLVRYDGNDPELIEAAIDAAKRIGAGHVFVLFIRDAWPINVLNQLKNVQEVASIFCATANPVQVIVAETQQGRGVMGVIDGFTVVGVESEEDKKKRVEFLRKIGYKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY19</accession>
    <name>A1RY19_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752364.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0697"/>
    <dbReference type="EnsemblBacteria" id="ABL78099">
        <property type="protein sequence ID" value="ABL78099"/>
        <property type="gene ID" value="Tpen_0697"/>
    </dbReference>
    <dbReference type="GeneID" id="4602012"/>
    <dbReference type="KEGG" id="tpe:Tpen_0697"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="68" mass="7585" checksum="6C0032A708713676" modified="2007-02-06" version="1">MRTVGAPSRILASTLRRDELYEARLAEALDAVEEFLASVKSAPRVEEDEELARELEKDVEELRGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY45</accession>
    <name>A1RY45_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752390.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0723"/>
    <dbReference type="EnsemblBacteria" id="ABL78125">
        <property type="protein sequence ID" value="ABL78125"/>
        <property type="gene ID" value="Tpen_0723"/>
    </dbReference>
    <dbReference type="GeneID" id="4601488"/>
    <dbReference type="KEGG" id="tpe:Tpen_0723"/>
    <dbReference type="eggNOG" id="arCOG14773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056112_0_0_2"/>
    <dbReference type="OrthoDB" id="121341at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="26668" checksum="9F56BCEBAB3574CE" modified="2007-02-06" version="1">MEALTAAVGAGLYAAVGLLYWFLGRRSESLRFFEDAALSAAFVVVVHVILGVSSQIATLAGVQLNLWSSADVSACARRASETFWEASRKAVDTVLFVEAERALLASTPVTSPLASVLGGATGWSTAELGIVAIVYMHLSFAAEAFSIVSPYLFAFGAALMPIPRLRRLGASLLSIYLSTAIAMAYSLQVTSDALRGVRVPSASSPLDWVNVAGVAGENAVLLGKALTLTSLAFALATVGGVGLASAFDSVFVGFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY47</accession>
    <name>A1RY47_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPases involved in chromosome partitioning-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0725"/>
    <dbReference type="EnsemblBacteria" id="ABL78127">
        <property type="protein sequence ID" value="ABL78127"/>
        <property type="gene ID" value="Tpen_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0725"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159106_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="26034" checksum="DD5014008C0E347D" modified="2007-02-06" version="1">MAVRVAFVSGSKGGTGKSVLSSLASFELASMGRKVLLVDLGELGSSTQLCLAEDPGPPYLSDFFQGKASWRDVIVASPWEKLFVAPSSKQQGPVDADSLEYLLEAVDGYVDFVVLDMPAYPGTLYDPVAALAEVLALVMNPDKLSFSAVGGWYVGREFARRKLALPVLNKYHPVMSPWLDRLREYFGAVFTVSFDPALTFAYTETIADAHKHLSKKTREEVKLLVQRLDKPLLKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY57</accession>
    <name>A1RY57_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Tpen_0735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752402.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0735"/>
    <dbReference type="EnsemblBacteria" id="ABL78137">
        <property type="protein sequence ID" value="ABL78137"/>
        <property type="gene ID" value="Tpen_0735"/>
    </dbReference>
    <dbReference type="GeneID" id="4601142"/>
    <dbReference type="KEGG" id="tpe:Tpen_0735"/>
    <dbReference type="eggNOG" id="arCOG13820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2893458_0_0_2"/>
    <dbReference type="OrthoDB" id="126926at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="zf-RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="62" mass="7007" checksum="D044D7CD887B676D" modified="2007-02-06" version="1">MSATSESRVAGPEPRCSVCGSRDVFAKIEGKYYCFKCGSRLVIEHSEKIVEEYVKKYIGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY75</accession>
    <name>A1RY75_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0753"/>
    <dbReference type="EnsemblBacteria" id="ABL78155">
        <property type="protein sequence ID" value="ABL78155"/>
        <property type="gene ID" value="Tpen_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0753"/>
    <dbReference type="eggNOG" id="arCOG05464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138325_1_0_2"/>
    <dbReference type="OMA" id="LNDECIG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="113" mass="13048" checksum="978D9900FA5390D3" modified="2007-02-06" version="1">MQRDVACSPLCPFRAFTCYKNALIYRRTKRGVEPFCTWTGEPCIGWKCQFAGCSKHALLPDGTCRLKLEKVQGRREEEEEFSIEEEAKALEKEVYGKIRDKLKKLGARVDDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY86</accession>
    <name>A1RY86_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0219 protein Tpen_0764</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. UPF0219 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752431.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0764"/>
    <dbReference type="EnsemblBacteria" id="ABL78166">
        <property type="protein sequence ID" value="ABL78166"/>
        <property type="gene ID" value="Tpen_0764"/>
    </dbReference>
    <dbReference type="GeneID" id="4601086"/>
    <dbReference type="KEGG" id="tpe:Tpen_0764"/>
    <dbReference type="eggNOG" id="arCOG01767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_7_0_2"/>
    <dbReference type="OMA" id="YAKHKGK"/>
    <dbReference type="OrthoDB" id="12601at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01409">
        <property type="entry name" value="UPF0219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004656">
        <property type="entry name" value="FabH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00748">
        <property type="entry name" value="HMG_CoA_syn_Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="3">
        <location>
            <begin position="220"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="346" mass="37290" checksum="94CD3D551D911598" modified="2007-02-06" version="1">MPGIASILGYGAYIPVYRIESGEISRVHTKGGEKAPVKQKSVPGPDEDSLTMAYEASKNALKRARLDPREVQALYIGSESPPYAVKPSATVVAEALGLSRKLYGIDMEFACKAGTTALISVAGLVKSGIITYGLAVGTDTAQGRPGDELEYTAGAGAAAFVVSPVRSDAVATIEHVYSYVTDTPDFWRREGERFPMHTFRFTGEPAYFHHIVSAAKGLFEETGLKPSDFAYAVFHQPNVKFPQRVGAMLGFKPEQLKLGLLSGEIGNTYAAASLIGLTNVLDHAKPGERILVVSFGSGAGSDALSIVVEEGIEDRRGLAPLTMQYVKRAKLVDYAVYLKYKDFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY94</accession>
    <name>A1RY94_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752439.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0772"/>
    <dbReference type="EnsemblBacteria" id="ABL78174">
        <property type="protein sequence ID" value="ABL78174"/>
        <property type="gene ID" value="Tpen_0772"/>
    </dbReference>
    <dbReference type="GeneID" id="4601094"/>
    <dbReference type="KEGG" id="tpe:Tpen_0772"/>
    <dbReference type="eggNOG" id="arCOG01995">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521950_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="176" mass="18815" checksum="CD1EC8960850FB04" modified="2007-02-06" version="1">MVAREGALSGAARATANPRLALTLVAVFLLVASYVLGFAQNITPEEARRVAQEYKGYIEGARRIKDPDAVAFGVFVNESLVILVCNTPVIGPVTAAYISFYSGYMDKALQVAGLEEATGTLEAYSLIEWVALVLATAEGLMLTYAFFRRRRVSPVETLASVLLQLSLIAIVAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RY98</accession>
    <name>A1RY98_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752443.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0776"/>
    <dbReference type="EnsemblBacteria" id="ABL78178">
        <property type="protein sequence ID" value="ABL78178"/>
        <property type="gene ID" value="Tpen_0776"/>
    </dbReference>
    <dbReference type="GeneID" id="4601837"/>
    <dbReference type="KEGG" id="tpe:Tpen_0776"/>
    <dbReference type="eggNOG" id="arCOG04060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077869_0_0_2"/>
    <dbReference type="OMA" id="KMAGEIT"/>
    <dbReference type="OrthoDB" id="55424at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017271">
        <property type="entry name" value="Tscrpt_reg_HTH_MJ1545_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037724">
        <property type="entry name" value="TF_HTH_MJ1545_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="248" mass="27363" checksum="8CF6B2A04B079BB4" modified="2007-02-06" version="1">MSHNSWASDPAIREIASKIAGEIIISDNPGLEMRKWREKFNVTQVELASIMNVSASVISDYESGRRKSPGARFIRKFVKSLIMKDLERGGIVLSGLRRILLGSDLLREAVLDMREFSIPISISRFCEAIDADLIVGQSYAATPLLGYTVVDSIKLVLDVPSYDYVKLYGATTQRAAIFTRVAYGRSPMVAVKSMQAGMGGLRPALVVLHGVKKVDELGLEIAKRENIPLAVTRVDTVENLIEKLRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYA8</accession>
    <name>A1RYA8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysS</name>
        <name evidence="10" type="ordered locus">Tpen_0786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752453.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0786"/>
    <dbReference type="EnsemblBacteria" id="ABL78188">
        <property type="protein sequence ID" value="ABL78188"/>
        <property type="gene ID" value="Tpen_0786"/>
    </dbReference>
    <dbReference type="GeneID" id="4601134"/>
    <dbReference type="KEGG" id="tpe:Tpen_0786"/>
    <dbReference type="eggNOG" id="arCOG00485">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_2"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="OrthoDB" id="9880at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_2" evidence="9">
        <location>
            <begin position="444"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="29"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="537" mass="61928" checksum="A76B5767C7BADFA1" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYE9</accession>
    <name>A1RYE9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752494.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0828"/>
    <dbReference type="EnsemblBacteria" id="ABL78229">
        <property type="protein sequence ID" value="ABL78229"/>
        <property type="gene ID" value="Tpen_0828"/>
    </dbReference>
    <dbReference type="GeneID" id="4601831"/>
    <dbReference type="KEGG" id="tpe:Tpen_0828"/>
    <dbReference type="eggNOG" id="arCOG05489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412424_0_0_2"/>
    <dbReference type="OMA" id="YENIYEE"/>
    <dbReference type="OrthoDB" id="112189at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="172" mass="19918" checksum="512F450CA0DE31BD" modified="2007-02-06" version="1">MEDLEPLSAMGLFVVTRRLEVYQTIIFDYFDSESYYYGLSEDMEKLEAELRKLAASMQSFLDEEEVILNGARVRPRVVGVDLGFRSSPEEPFITYFIYFRGKPVKGVNYYENIYENTVAEYPITAYWFFPPRSSVGKVEASGEVEIIGSNIVVLRVDEGEKIYGYERIEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH3</accession>
    <name>A1RYH3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752518.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0852"/>
    <dbReference type="EnsemblBacteria" id="ABL78253">
        <property type="protein sequence ID" value="ABL78253"/>
        <property type="gene ID" value="Tpen_0852"/>
    </dbReference>
    <dbReference type="GeneID" id="4601977"/>
    <dbReference type="KEGG" id="tpe:Tpen_0852"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445256_0_0_2"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="615" mass="67136" checksum="CB0E53D816EE4B0A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH7</accession>
    <name>A1RYH7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="6">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_0856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0856"/>
    <dbReference type="EnsemblBacteria" id="ABL78257">
        <property type="protein sequence ID" value="ABL78257"/>
        <property type="gene ID" value="Tpen_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0856"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="VIGRIYI"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="10">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="31169" checksum="D3599D05D431A1EE" modified="2007-02-06" version="1">MTALDPAIYDTGKRPVWCPGCGNYGVLLALRKALAELELKPENVVIVTGIGCHGRISDYMKTNGFHTIHGRVLPLATGIKLANPNLTVIGHSGDGDAYAIGLGHLPHAARRNIDIKLIVHNNMVFGLTTGQVTPTTPLGVKTKSTPFGNPEHPLNPLLLALASGATFVARGFSGEVDHLKELIKRAILHKGFAFIDVLQPCVTFFNTYSILREKVYKLEETGHDVKSLEQAFRRAMETERIPIGVFYEVERPTLEEAFSHAMNPPPALRPLSPPDLTRLLSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH9</accession>
    <name>A1RYH9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0858"/>
    <dbReference type="EnsemblBacteria" id="ABL78259">
        <property type="protein sequence ID" value="ABL78259"/>
        <property type="gene ID" value="Tpen_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0858"/>
    <dbReference type="eggNOG" id="arCOG00463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_0_0_2"/>
    <dbReference type="OMA" id="IPRYFLG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="165" mass="17685" checksum="428255311179772F" modified="2007-02-06" version="1">MSCVGKAMMPADNVAPSGKGIYILLIVLKSDAKLSSISGKEVTLRAGIYLYLGSAKGPGGLRARVSRHLRREKRVHWHIDRLLAAPGASVAYVVYGETHLPECVLTRPLEELGCRHPLPGFGSSDCKHGCTSHLLECGGGEKDCLEKAVEAFRRNGVTPGVLHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYS9</accession>
    <name>A1RYS9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0959"/>
    <dbReference type="EnsemblBacteria" id="ABL78359">
        <property type="protein sequence ID" value="ABL78359"/>
        <property type="gene ID" value="Tpen_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0959"/>
    <dbReference type="eggNOG" id="arCOG00816">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_2_1_2"/>
    <dbReference type="OMA" id="RNPLEDM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="81" mass="9335" checksum="4CE0BDEB1171017E" modified="2007-02-06" version="1">MQTVEVVRVTERYRVTIPLSVRRELGIKVGDKLRVRVEGKRIILEPIPEEPRNPLEDMLSILDKPVDVDAVRLVEGSWSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU9</accession>
    <name>A1RYU9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0979"/>
    <dbReference type="EnsemblBacteria" id="ABL78379">
        <property type="protein sequence ID" value="ABL78379"/>
        <property type="gene ID" value="Tpen_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0979"/>
    <dbReference type="eggNOG" id="ENOG502N59U">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2434025_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="10721" checksum="49F10E9C6AE97400" modified="2007-02-06" version="1">MMAQEISEIRKRLARLREELARLERRIAQVEFKMASSGEERIKAVEEELKEEYPGMKFDRDLLELVGILPYNPVEEDEEVVREAILKKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYX2</accession>
    <name>A1RYX2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752667.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78402">
        <property type="protein sequence ID" value="ABL78402"/>
        <property type="gene ID" value="Tpen_1002"/>
    </dbReference>
    <dbReference type="GeneID" id="4601558"/>
    <dbReference type="KEGG" id="tpe:Tpen_1002"/>
    <dbReference type="eggNOG" id="arCOG07626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529306_0_0_2"/>
    <dbReference type="OMA" id="EIPGSAC"/>
    <dbReference type="OrthoDB" id="131972at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="175" mass="19243" checksum="C9D30ECC9D4B5C55" modified="2007-02-06" version="1">MWNVENAIKRNANVYHVYIACMIAKFRELGLVNYGVIKGAAEATGRCTADYFLAHGLKPSSVEDAIVALNEITGFTDEVKVDYRDGVLEVRMHRDSCRICPRMVGGLELPGAACPNVGYIKGFVEGLGLAKLEDFAREKGEEPVTKDGEYCVIRYVVKEASAPVKEEKAVAARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ54</accession>
    <name>A1RZ54_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase, chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752749.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1085"/>
    <dbReference type="EnsemblBacteria" id="ABL78484">
        <property type="protein sequence ID" value="ABL78484"/>
        <property type="gene ID" value="Tpen_1085"/>
    </dbReference>
    <dbReference type="GeneID" id="4601697"/>
    <dbReference type="KEGG" id="tpe:Tpen_1085"/>
    <dbReference type="eggNOG" id="arCOG03073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_1_1_2"/>
    <dbReference type="OMA" id="ILYYRTH"/>
    <dbReference type="OrthoDB" id="131542at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="101" mass="10669" checksum="63C93F353EF9CA43" modified="2007-02-06" version="1">MIEALYAYLAASAALFGIGALGAVVSRSVVKVMISLEIMFNGVLLALLTLASMGNPLVGYTLSLFAIALSSVEVGLLVSVFILLYRRTRSLDVYEIPGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ67</accession>
    <name>A1RZ67_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system fructose subfamily IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1098"/>
    <dbReference type="TCDB" id="4.A.6.1.24">
        <property type="family name" value="the pts mannose-fructose-sorbose (man) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78497">
        <property type="protein sequence ID" value="ABL78497"/>
        <property type="gene ID" value="Tpen_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1098"/>
    <dbReference type="eggNOG" id="arCOG14932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123235_1_1_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="129" mass="13775" checksum="3BB367937260AE03" modified="2007-02-06" version="1">MREAVAMILGVSVKEVTDCVELLEGESFENYYEKLASRVDGDTIVLADLFGGTPSKAALMLLQESKVKAVITGFNMAMVIQLLSSQDEDLESLVLGAKSAGMEGVRAFVGPGLRELTGKKEEGPSGKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ80</accession>
    <name>A1RZ80_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane-associated protein/domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1111"/>
    <dbReference type="EnsemblBacteria" id="ABL78510">
        <property type="protein sequence ID" value="ABL78510"/>
        <property type="gene ID" value="Tpen_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1111"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079811_0_0_2"/>
    <dbReference type="OMA" id="RIINYTM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="303" mass="31901" checksum="FCA3472DC1BAA111" modified="2007-02-06" version="1">MVMLAALITVCVILPAGSVPVNSVAITILPTGVAKVDYSVSVGNASLLDIQLVGTPLPEYGVVVVDEHGTPLAYMVNETTGTMRIITLGSSLVSISYFTSSILSMSKGVWTVSYVSPLPSTVRLPAGTALSSLSTVPTSVTVQNQSLVLSFQPGRVSFSYVYVPQQPPQQAPPQTSQPSRVNASQPASQPQPTPSPQQPAPAKTTPSGMPIEPLYIAVLGAAGAAVVLALLLKARGGRELGEEDEEIIGVLKKLGGGAFQSDIGLYVSLPPTTLWRRIRRLEKLGYVKIEKKAGRNFVRLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC2</accession>
    <name>A1RZC2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752817.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1154"/>
    <dbReference type="EnsemblBacteria" id="ABL78552">
        <property type="protein sequence ID" value="ABL78552"/>
        <property type="gene ID" value="Tpen_1154"/>
    </dbReference>
    <dbReference type="GeneID" id="4602156"/>
    <dbReference type="KEGG" id="tpe:Tpen_1154"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062979_2_0_2"/>
    <dbReference type="OMA" id="GGAPWLM"/>
    <dbReference type="OrthoDB" id="86536at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="119"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="344" mass="38407" checksum="D7CBA337B2F230AE" modified="2007-02-06" version="1">MEGAELSLKDLYRLAESLGLREYEARAYIALVLYGSMTATELAKRSELPQPRVYDVVKALEEKGLVAISEGKPRKFSALDPRVALKRYVERRHAEETSTLNSILRLLESASLRREEPGVWTAVGQNAGESLFLSALESARHELLVAGYSKFLRGFLDRLARTDLATCLVLYDGEDIGSFVNVFDEVRLRPTRAPQMAIPDFSQVVIVSGWESGQVTAYKVTDDNLMRIFAVYYLDYLRGSGKVVAAKFGQLERRTYHHMTRALEHINALLGAGRKPVLTVRGRWVATGEEATVRGVPVRLFENSFRSVGTILLKLEDGREVSVGGVGAYLEDVEAYEITVEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD2</accession>
    <name>A1RZD2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1164"/>
    <dbReference type="EnsemblBacteria" id="ABL78562">
        <property type="protein sequence ID" value="ABL78562"/>
        <property type="gene ID" value="Tpen_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1164"/>
    <dbReference type="HOGENOM" id="CLU_388140_0_0_2"/>
    <dbReference type="OMA" id="MTNTEFP"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="714" mass="79920" checksum="5487E54AA0443400" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF4</accession>
    <name>A1RZF4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752849.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1186"/>
    <dbReference type="EnsemblBacteria" id="ABL78584">
        <property type="protein sequence ID" value="ABL78584"/>
        <property type="gene ID" value="Tpen_1186"/>
    </dbReference>
    <dbReference type="GeneID" id="4600431"/>
    <dbReference type="KEGG" id="tpe:Tpen_1186"/>
    <dbReference type="eggNOG" id="arCOG11614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470633_0_0_2"/>
    <dbReference type="OMA" id="TEFNDWF"/>
    <dbReference type="OrthoDB" id="26879at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="582" mass="66374" checksum="E31BAD565C6220FB" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZK0</accession>
    <name>A1RZK0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1232"/>
    <dbReference type="EnsemblBacteria" id="ABL78630">
        <property type="protein sequence ID" value="ABL78630"/>
        <property type="gene ID" value="Tpen_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1232"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_2"/>
    <dbReference type="OMA" id="NAPYFCQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="286" mass="31763" checksum="79B14DFCCEDCCBA5" modified="2007-02-06" version="1">MSSSFNNPSRVLGDVVRVALHQLAVSGEKRENLEKALRLLELGDAYLHVFPEYLMGVDPGGPTRDYVWRVAEPIDGEFASRIVEKTGELGVAAVFTMFLREGPGVYNAAVLAEEGKVKAVYRKIHLFDAYGYRESSVFSPGREPVVADLKGLRLGIAVCFDLRFPELFRSMFLRGAEVFVVPSAWYRGPYKVEQWKALTAARAHENTSYLVAVNQVGESFTGHSLVATPLGHLLVDLGEGERSIAVDLDEGELASARERIPVRDLLRLELYREWYAGFKRPGEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL0</accession>
    <name>A1RZL0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752905.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1242"/>
    <dbReference type="EnsemblBacteria" id="ABL78640">
        <property type="protein sequence ID" value="ABL78640"/>
        <property type="gene ID" value="Tpen_1242"/>
    </dbReference>
    <dbReference type="GeneID" id="4600537"/>
    <dbReference type="KEGG" id="tpe:Tpen_1242"/>
    <dbReference type="HOGENOM" id="CLU_1369598_0_0_2"/>
    <dbReference type="OrthoDB" id="130045at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="22555" checksum="F19E1608CB954E39" modified="2007-02-06" version="1">MYYVDVSAKALRRVERLRKAWYPYAAFRRAGEPGYLYLFDCFAGARGGRRALILLARRIPEGAVKEGDPPVAAPLVPSRDCNEGIVRGIPPPPQPRERPLGASFEAVDYFAVRMLGVRGAMRRVEEFFKGFVDTGGLLDAIAEELRVGELEFRGVVYQLVAVEGGRVYLAAGGKVERLRVLERFLEVDREAAEELWRVLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZL1</accession>
    <name>A1RZL1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752906.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1243"/>
    <dbReference type="EnsemblBacteria" id="ABL78641">
        <property type="protein sequence ID" value="ABL78641"/>
        <property type="gene ID" value="Tpen_1243"/>
    </dbReference>
    <dbReference type="GeneID" id="4600538"/>
    <dbReference type="KEGG" id="tpe:Tpen_1243"/>
    <dbReference type="eggNOG" id="arCOG10988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340790_0_0_2"/>
    <dbReference type="OrthoDB" id="100117at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="165" mass="18378" checksum="B5FDBD20FA68116B" modified="2007-02-06" version="1">MSFYNYDFQSERVGLDNVDWPVSLVFAGFGGAGEVRGLFFGGTPYGNEMKMQVWPAGTWLGDRGTKGVVYSPTFNAYLYLHMRVYEVRAGEITAVGTTHYDQFPVESWSGYTSLASGDFLAMAGRRGLRVRADELFLLNAEGFSFEENHPRLHTGYAGLVSRVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN6</accession>
    <name>A1RZN6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752931.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1268"/>
    <dbReference type="EnsemblBacteria" id="ABL78666">
        <property type="protein sequence ID" value="ABL78666"/>
        <property type="gene ID" value="Tpen_1268"/>
    </dbReference>
    <dbReference type="GeneID" id="4600483"/>
    <dbReference type="KEGG" id="tpe:Tpen_1268"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OMA" id="CLHINLG"/>
    <dbReference type="OrthoDB" id="57500at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="52"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="323" mass="34502" checksum="BCE6223FFB030C8F" modified="2007-02-06" version="1">MHARCSVCGEPAVARVEYARKWLCGAHFAGYVEGKVLGALERYRLVERGWRVLAAVSGGADSAAMLGVLAKASVALGFRLAAVHVDLGIEGFSEASRRAVEELCGSLGVPFAVVSLPEVAGVGLPELARRARRPVCSVCGAVKRYLVNVAAAEAGADVVALGHHADDLLAYAVKNFLFQRLPELAKLGPKTESTGGLVGRVRPLYEVYKSEASLYARLSGLPFTEERCPYSPNRSVEGEVRAFLDSVEARRPGFKISLARGLARNAGLWGQGPRSPPRACRVCGAPSEGELCSFCRLTLKALGRPMGDVAREKVREAVSAIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN9</accession>
    <name>A1RZN9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1271"/>
    <dbReference type="EnsemblBacteria" id="ABL78669">
        <property type="protein sequence ID" value="ABL78669"/>
        <property type="gene ID" value="Tpen_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1271"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_1_0_2"/>
    <dbReference type="OMA" id="YYTCHCT"/>
    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="60"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="272" mass="28356" checksum="0CFDAF2986C702D2" modified="2007-02-06" version="1">MRGATVPVDKRYAYAALVALLAAAPFAWLAVRREARAHAATARLVVLVDNEALGGLESAWGLSVYVEAGGARLLFDAGPEPGVLERNAARLGVDLSRIDAVVVSHGHYDHVGGLRLFAGRGLRVYVPAGSGLSGYVSGLGLRPVEVDETTMLAPGVYVVKPLVGPPPEEALAIVTGKGLVLVVGCSHPGVVNIARQAIRDVGAKPYAVLGGFHMAGASQREVKEVVEGLLSLGFEKIYPLHCSGEGVKRYLAERHPEAYGDGGAGLVVEIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZS9</accession>
    <name>A1RZS9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1312"/>
    <dbReference type="EnsemblBacteria" id="ABL78709">
        <property type="protein sequence ID" value="ABL78709"/>
        <property type="gene ID" value="Tpen_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1312"/>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230519_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="105" mass="11327" checksum="DE22793A1B4C8273" modified="2007-02-06" version="1">MNLRFGEEVKGFLYAYAGEKGLEVGFIDRGGEPGGVARVEGASTPWKVKYLVENYGGIPGIVVEGEAPGKEPLLVILGRSAAEVAEMAVEVARRYAEWRSKRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZU5</accession>
    <name>A1RZU5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1328"/>
    <dbReference type="EnsemblBacteria" id="ABL78725">
        <property type="protein sequence ID" value="ABL78725"/>
        <property type="gene ID" value="Tpen_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1328"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="SYCDVNE"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="195" mass="21530" checksum="873D94BD64BC9126" modified="2007-02-06" version="1">MLELRNLVVGYSEPLTKALNLQFERGSAIAFFGPNGVGKTTLLKTLSTLLEPLEGYVLLNGEAAEKRRQRIFYLTELIDVPLRVTAKQYVDAVSGFYPDSIDSLEALRLAGVPPNVKLGKLSMGMRRRAQLAAALAVAPYVELMCLDDPFVGVDAQSSSRILEHFKRDNYVLVVASRTPVEGLENIDFSTLKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZV1</accession>
    <name>A1RZV1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1334"/>
    <dbReference type="EnsemblBacteria" id="ABL78731">
        <property type="protein sequence ID" value="ABL78731"/>
        <property type="gene ID" value="Tpen_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1334"/>
    <dbReference type="eggNOG" id="arCOG02081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457606_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="470"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="596" mass="64444" checksum="24F65434CC3586C6" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW7</accession>
    <name>A1RZW7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753012.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1350"/>
    <dbReference type="EnsemblBacteria" id="ABL78747">
        <property type="protein sequence ID" value="ABL78747"/>
        <property type="gene ID" value="Tpen_1350"/>
    </dbReference>
    <dbReference type="GeneID" id="4600874"/>
    <dbReference type="KEGG" id="tpe:Tpen_1350"/>
    <dbReference type="eggNOG" id="arCOG01108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_0_1_2"/>
    <dbReference type="OMA" id="EHHAHGV"/>
    <dbReference type="OrthoDB" id="63703at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017145">
        <property type="entry name" value="Aminobenzoyl-glu_utiliz_pB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037227">
        <property type="entry name" value="Aminobenzoyl-glu_utiliz_pB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="185"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="473" mass="51941" checksum="C2EDC2AC1E0E2B37" modified="2007-02-06" version="1">MVKEYALEWIDGYRERLVKVSDAIWEYAELGLREFKSSRLLAGELERHGFRVEMGVAGMPTAFVATWGSGRPVIGILGEYDALPGLSQKVVPWREPLVPGAPGHGCGHNIHGASGMAAALAVKAAMEREGLGGTVKFFGCPAEENFSGKVFMVRDGVFEGVDAVLSHHPGDMNAATLKSSLAVNSARFHFYGRASHAGASPEEGRSALDAVQLMNIGVEFMREHLPQDARVHYVVERGGGQPNVVPEYARAWYYVRAPEREEVERIYSWVVDIARGAALMTQTRVEVEFLEGVYNLLPNRVLAELVVGNMREVGLPEYSEEDLRFAEEIAKTIPREVKVGQLRKSGRPGWERLVDKLIDDEVPDPWGEGTVMHGSTDVADVSWQAPTLEFSTAAWVLGTPAHSWQAVAQSAAGIGHKALIFASKVLAASALDLLTKPEILEKAKEEHKRRLAGRVYRSPLPPGHKPPLDAWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX7</accession>
    <name>A1RZX7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78757">
        <property type="protein sequence ID" value="ABL78757"/>
        <property type="gene ID" value="Tpen_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1360"/>
    <dbReference type="eggNOG" id="arCOG01439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029036_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="2">
        <location>
            <begin position="116"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="277" mass="30533" checksum="4BCF82699DC4A882" modified="2007-02-06" version="1">MRDALLPPFTSKVTRTAFAALWGLDPETMGRRASFSVLFRGDRPLYKLAGEEAPLLAREGEVLRARVSMLWDGAPGLPRQEAVFVFGAAEMRARVAEVEVFEASALREDVPEKFALRFLTPTLVPVPGRGSLLKAGGPRRRYRLVPDLPLALAHLAYDAAMRGVRLAKATPGRIHAWALRALAELDYDARPVTALYTVRDGKPATERGFVGFVAYELLDTKSEYAEDFRRLMAFALRFGIGRSRSIGFGHVEMSPLGPPRRLRAAPRKPGGHARAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZX8</accession>
    <name>A1RZX8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753023.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1361"/>
    <dbReference type="EnsemblBacteria" id="ABL78758">
        <property type="protein sequence ID" value="ABL78758"/>
        <property type="gene ID" value="Tpen_1361"/>
    </dbReference>
    <dbReference type="GeneID" id="4602198"/>
    <dbReference type="KEGG" id="tpe:Tpen_1361"/>
    <dbReference type="eggNOG" id="arCOG02666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317052_0_0_2"/>
    <dbReference type="OMA" id="YRYLEAR"/>
    <dbReference type="OrthoDB" id="21880at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="919" mass="98982" checksum="B68DAC267FB00681" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY8</accession>
    <name>A1RZY8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753033.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1371"/>
    <dbReference type="EnsemblBacteria" id="ABL78768">
        <property type="protein sequence ID" value="ABL78768"/>
        <property type="gene ID" value="Tpen_1371"/>
    </dbReference>
    <dbReference type="GeneID" id="4601196"/>
    <dbReference type="KEGG" id="tpe:Tpen_1371"/>
    <dbReference type="eggNOG" id="arCOG07320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052193_0_0_2"/>
    <dbReference type="OMA" id="CIYCPGI"/>
    <dbReference type="OrthoDB" id="21885at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="270" mass="28721" checksum="D61A388274D29E62" modified="2007-02-06" version="1">MVSLKALRAVKVTPGLAARLALLPFRRVKNPCIYCPGICLASCPTYTATGNVLLSPLGYSRFKEVAAKNCLKCWRCSFECPLGFQLPETYSPEPAKPRLHSLKPGETVLVADLELDAPYAEKLAEALGTGLALVSGVAARYSEGRPLDAGATKKLVKRLGGAEALVAASPEVSHALGVDFFALHLAELGVKISYEGPVHVPCLLKPVEEKLLKALEEAGVKATEVDDESCIKQGVKKGYLYLCPRAAALGATTIYDLASTQELRGAAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S026</accession>
    <name>A1S026_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753071.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1409"/>
    <dbReference type="EnsemblBacteria" id="ABL78806">
        <property type="protein sequence ID" value="ABL78806"/>
        <property type="gene ID" value="Tpen_1409"/>
    </dbReference>
    <dbReference type="GeneID" id="4601823"/>
    <dbReference type="KEGG" id="tpe:Tpen_1409"/>
    <dbReference type="eggNOG" id="arCOG01503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_0_3_2"/>
    <dbReference type="OMA" id="FCVDRIQ"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="286" mass="31120" checksum="9F69C768157419C7" modified="2007-02-06" version="1">MVLQKFPSLSEGYAVLVDLDKCIGCRACQVACKDWNSRQAEKTTFSPTFTNPPDLTANDWKVVFYYEGKSKKALLTPAGEVVFEQVDVVPLPFQCMHCATAPCSRACPVGAIKVTPEGAVVISKEECIGCGFCETACPFRVPRRGSDGKYYKCTFCVDRIQNGRAPACVEACPTGVFTFGKAGDIIEKAKELQSTGKTVFGLNLDSYVGGGVRWIYAGSERRSYAIKEHFADRGKPVATQEGRELLKPLILYGGALGALALAAIGVATWRKSRVEEVKSSSQEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S030</accession>
    <name>A1S030_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753075.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1413"/>
    <dbReference type="EnsemblBacteria" id="ABL78810">
        <property type="protein sequence ID" value="ABL78810"/>
        <property type="gene ID" value="Tpen_1413"/>
    </dbReference>
    <dbReference type="GeneID" id="4600730"/>
    <dbReference type="KEGG" id="tpe:Tpen_1413"/>
    <dbReference type="eggNOG" id="arCOG00709">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="HDEKWHT"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="625" mass="69234" checksum="37701FC94A3B318A" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1S061</accession>
    <name>A1S061_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">Tpen_1444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753106.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1444"/>
    <dbReference type="EnsemblBacteria" id="ABL78841">
        <property type="protein sequence ID" value="ABL78841"/>
        <property type="gene ID" value="Tpen_1444"/>
    </dbReference>
    <dbReference type="GeneID" id="4601153"/>
    <dbReference type="KEGG" id="tpe:Tpen_1444"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="OrthoDB" id="89944at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="279" mass="31556" checksum="C169AA1F7F0E27BE" modified="2007-02-06" version="1">MRYVLPPINAERVAEYIARRLRWYVREYAGKRAGVVGVSGGVDSAVVAFLTARALGPENTYCYVLPSFATPKEDVEDALRVIEALGLPDGNWEVISVDPILKSFEEVLGEMDRVARGNVMARIRMIILHEKAYAHNALVIGTGDKSELLLGYFTKYGDGGVDVLPIGGLYKTHVRQLARYLGVPERIVEKPSSPRLWPGQTAEGELGAPYELVDSVLYLRFEKWLPEERIAEELGVEVGVVKRILEMVKRSQHKRMMPEVFHVGQRDLGSDWRYPRQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1S068</accession>
    <name>A1S068_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1451"/>
    <dbReference type="EnsemblBacteria" id="ABL78848">
        <property type="protein sequence ID" value="ABL78848"/>
        <property type="gene ID" value="Tpen_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1451"/>
    <dbReference type="eggNOG" id="arCOG00160">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="FIGGWTE"/>
    <dbReference type="OrthoDB" id="90707at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="235"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="444" mass="48379" checksum="104968BFD26E53D0" modified="2007-02-06" version="1">MRAQQKARRSDFFKSAVLTLLALVVMGVLLFPVYYMFMVSLKPVGTLATTSLEVIPSKVTLDNYLEILVGHYEATLDVKSFALRAQNATISDALNRYEVDLYDGVVAGDYPVKFTLSNAKILERRGGQERGERDATIIVGGDYLKVGADSAETITAARRLTVEARKIVVKVSGPGGAPLDLSKFREVAPGVYEAENARLYLEDGGRISAEKCTVETTSFSYIRLAKVGGEIWGYMSRSLIIASLTVVLTLLFVVPSAYAFSRLKFFGKGHILYSYLMFTQVAGGLGIAGLVALYGMLVRLNLVNNIFVLPVIYAAGSVPFNTWLLKGYLDSISPDFDEAALVDGASYAQIIGQVLVPMALPGIATVAIFSFIGGWTELILANLLLNQENHPLTVYIYVLLTNLRNVSWNQFAAAALIFALPVVVMFLLAQNYVRSGLTMGGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S083</accession>
    <name>A1S083_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753128.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1466"/>
    <dbReference type="EnsemblBacteria" id="ABL78863">
        <property type="protein sequence ID" value="ABL78863"/>
        <property type="gene ID" value="Tpen_1466"/>
    </dbReference>
    <dbReference type="GeneID" id="4601584"/>
    <dbReference type="KEGG" id="tpe:Tpen_1466"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OMA" id="VHYSIEF"/>
    <dbReference type="OrthoDB" id="99962at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="144" mass="15545" checksum="45D0A649231E6050" modified="2007-02-06" version="1">MFARILVAYDGSEHARKALEVAVDLASKYGAKLFVVEVVDSKSLTSSLREVPSLDVGRVIAEIKSKASVDVRECLRLAQSRGVDAEGDVLEGDPASEILRYAEEVKADLIVTGSRGLSLWKRIFIGSVSSKIVSESKVPVLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S093</accession>
    <name>A1S093_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753138.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78873">
        <property type="protein sequence ID" value="ABL78873"/>
        <property type="gene ID" value="Tpen_1476"/>
    </dbReference>
    <dbReference type="GeneID" id="4601577"/>
    <dbReference type="KEGG" id="tpe:Tpen_1476"/>
    <dbReference type="HOGENOM" id="CLU_796011_0_0_2"/>
    <dbReference type="OrthoDB" id="141728at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="348" mass="36805" checksum="B242A385B7ACFC5D" modified="2007-02-06" version="1">MVKRVSILALLAALLATSVLLWLNLSASKAPPQTLPESLGPPRELYSASKGCLNGVAAPSSPEEPAQATLPAGVPSGLGYLALVEKCPGVALREGQTLVLEYSLGPTLLFVEAEEGGDVKAEPGNARLVVSVSRRGGVYAVNFTLALSGAPLRGGGNMSLVKTLTLLYDGAAYYLPNGTRVGLVFPLFARGRELELSFLWARPGEPYKLESLRPATARMKLLTVLDMERMLVAEVNVSSGEVVLARPLNRPLSQEAELASALAALGGCPRLFALATYSSRALPLHLVVDYASGIPVFALMRGAQRTLPTSKVVWEGRVLDEVPASTLAALLGVRSDLALTLERVQLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0C8</accession>
    <name>A1S0C8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Tpen_1511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1511"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78908">
        <property type="protein sequence ID" value="ABL78908"/>
        <property type="gene ID" value="Tpen_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1511"/>
    <dbReference type="eggNOG" id="arCOG06070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_2"/>
    <dbReference type="OMA" id="EHIYHAA"/>
    <dbReference type="OrthoDB" id="24300at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="202"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABL78908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="460" mass="52774" checksum="1666187B46122772" modified="2007-02-06" version="1">MSRVPKIKISVIGAGSVAWSSKLVHDLLHTPSLYGSDVYFMDINEERLRILRGLAEKYKSEVGAEYNFFYTTDRKEAVRDSDVVINTAMYGGHRYYELMREVSEKHGYYRGVNSVEWNMVSDYHTIWGYYQWKLAMDIARDVEELAPGAWLIQMANPVFELTTLISRETRVKVVGLCHGHLGYKEIAQTIGLDPARVGFEAIGFNHVIWLTKFTYDGEDAYPLIDRWVEEKAEQYWSQWRMRQVNPFDIQMSPAAVDMYRRYGLFPVGDTVRGGTWKYHSSLKTKQYWYGPTGGPDSEIGWALYTAHQEYWLATLAQAASDPRIPVSSLFPQTRTEESVVPLIESLMLDKPGEYQVNVLNGNAIEGIPSNVAVEVPARVDARGIHPKTGLRLPRKILSLVMQPRLLRAEMAIAAFLEGGRQFLIDWLMLDPRTRSEEQAEKVWEEILSLPGNEEMKRHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0D6</accession>
    <name>A1S0D6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinitrogenase iron-molybdenum cofactor biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1519"/>
    <dbReference type="EnsemblBacteria" id="ABL78916">
        <property type="protein sequence ID" value="ABL78916"/>
        <property type="gene ID" value="Tpen_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1519"/>
    <dbReference type="eggNOG" id="arCOG02734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_0_3_2"/>
    <dbReference type="OMA" id="YLSPHFG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="107" mass="11520" checksum="8B1DCAE1715AC9FD" modified="2007-02-06" version="1">MSPHFGRAPFFAVVVVEGGSAKLERVERNPVAPTVEEGRGHAVLGFVLSLRPDAVVVKDIGAGAFYRLREAGVEVYAVDRHVEVVEAASMLARGELRRLEAPTESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G4</accession>
    <name>A1S0G4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753209.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1548"/>
    <dbReference type="EnsemblBacteria" id="ABL78944">
        <property type="protein sequence ID" value="ABL78944"/>
        <property type="gene ID" value="Tpen_1548"/>
    </dbReference>
    <dbReference type="GeneID" id="4600841"/>
    <dbReference type="KEGG" id="tpe:Tpen_1548"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="STQMFPG"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="270" mass="29273" checksum="35ABDF583B5B2CD8" modified="2007-02-06" version="1">MPVRRSILLSIVGALLSAWILVPLAYTMLAAFADPEDYYRHVIPTKYTLENVNVFLELGALDAMARSVLVAFLTIAISFAVGVPAGYAVGRWVFRGKDSYRLAVLSMRMFPVMVMAIPLASLYIRLGLYDSLLGVALVHAALALPFVVLITSSIFVSIPRDLEEAGLVFGLSRVQVFTKITAPLALPGLSAAAMFTFVTSWNEVFASTILTLKERTLPALTVATTILSTGAAAPDPYRFAAATLLALPAFIVMLYMRKYLTVMWGGARVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G5</accession>
    <name>A1S0G5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1549"/>
    <dbReference type="EnsemblBacteria" id="ABL78945">
        <property type="protein sequence ID" value="ABL78945"/>
        <property type="gene ID" value="Tpen_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1549"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_2"/>
    <dbReference type="OMA" id="LWYSVQS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="284" mass="31553" checksum="C2743C4DD0FF08C4" modified="2007-02-06" version="1">MNNRFFSPSKAMPYLLILPSMLYMLAFIGYPLVQSLSWALLPDSHGSIPIVRILTSERFSEVLVNTFLLLLAIVPAQFALALLASLVLVQRFPGREVSLYFFTVPLALSDVSAALIWYTMLSSRGFLNKLLMEAGLISSPIQFFGYAFRNMEFLAIVLTEVWRATAIVFINIYAGFQTINRELLEAADVFGLSSLQKLRYVTLPLLKPSIQSALIIRTLFALQTFAPVLILAGFDIPVLATEAFYQYTLVMDVPTAAAWSLLIGAVTFALGAFYLRALRTPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0G8</accession>
    <name>A1S0G8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753213.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1552"/>
    <dbReference type="EnsemblBacteria" id="ABL78948">
        <property type="protein sequence ID" value="ABL78948"/>
        <property type="gene ID" value="Tpen_1552"/>
    </dbReference>
    <dbReference type="GeneID" id="4600901"/>
    <dbReference type="KEGG" id="tpe:Tpen_1552"/>
    <dbReference type="eggNOG" id="arCOG04085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418995_0_0_2"/>
    <dbReference type="OMA" id="IIRHESQ"/>
    <dbReference type="OrthoDB" id="12504at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028212">
        <property type="entry name" value="GHL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14871">
        <property type="entry name" value="GHL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="718" mass="80351" checksum="95610B070A964CFC" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0I6</accession>
    <name>A1S0I6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753231.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1571"/>
    <dbReference type="EnsemblBacteria" id="ABL78966">
        <property type="protein sequence ID" value="ABL78966"/>
        <property type="gene ID" value="Tpen_1571"/>
    </dbReference>
    <dbReference type="GeneID" id="4601529"/>
    <dbReference type="KEGG" id="tpe:Tpen_1571"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625034_0_0_2"/>
    <dbReference type="OMA" id="NIWLWKV"/>
    <dbReference type="OrthoDB" id="84185at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="433" mass="48799" checksum="1B044CBE0C223F75" modified="2007-02-06" version="1">MPRFADLFVREVRRKRSELERILGSEGGLRERYGELVREAWIRDLEPRGARGPAYAVDSSSDDIEVQGGGVVLVTRSLALSAGGEEIRELRLDAFYPRNVRDYDDFKRLVREHVEHVVALRAVEEGARLVLIDGSLYGRMIHVLRELEVEGREDFMFEYVELYSELFSKARSRGALVVGVSKDSRSTVLKEELLYLRLKSVLKGLGEPLAGAVLGYWRLLKRRPREALENVRKLVREGLSPEVYELFEEATSSVPDSKVILACDPGRGFSRPLRLSLEKVSTGVTDILLTDGARGAALLRDVFEKTAERLGEEFDERASQVLECMKKYPPVVTSYAVFSRGDDPLRVDLAGGSGYETAGDSRFLAETPGELLEVLGFLALLYAGRRRYNALLLEADRRVKATAETMELYHRLAMQELGLAIIHSRGDRRVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0J6</accession>
    <name>A1S0J6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753241.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1581"/>
    <dbReference type="EnsemblBacteria" id="ABL78976">
        <property type="protein sequence ID" value="ABL78976"/>
        <property type="gene ID" value="Tpen_1581"/>
    </dbReference>
    <dbReference type="GeneID" id="4600567"/>
    <dbReference type="KEGG" id="tpe:Tpen_1581"/>
    <dbReference type="eggNOG" id="arCOG00701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_4_2"/>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="OrthoDB" id="51024at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="236" mass="26009" checksum="2E949F39B5C3AE4D" modified="2007-02-06" version="1">MDTVSIGRLFEGFFVVAHRGASGYEPENTLRAVRRALEMGVDAVEVDVRLSADGVPVVIHDETLERTTSGRGRVRDYPVDELRMLDAGSGERIPLLAEVLDEVKGKAALFLELKEVEAAAPSLSLVEEKGMLGDVLFISLQPEALAEVRRMSPRAYLGLIYFKPGEWILEAKRLGCSFVLPHYRLATEKAVSFAHRLKLRVVAWTVDDPATAAELKKRGVDGVASNFPDRILPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K0</accession>
    <name>A1S0K0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753245.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1585"/>
    <dbReference type="EnsemblBacteria" id="ABL78980">
        <property type="protein sequence ID" value="ABL78980"/>
        <property type="gene ID" value="Tpen_1585"/>
    </dbReference>
    <dbReference type="GeneID" id="4600549"/>
    <dbReference type="KEGG" id="tpe:Tpen_1585"/>
    <dbReference type="eggNOG" id="arCOG00837">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640062_0_0_2"/>
    <dbReference type="OMA" id="LNENIEC"/>
    <dbReference type="OrthoDB" id="95090at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="161" mass="18158" checksum="71F0B986A27A6E66" modified="2007-02-06" version="1">MASRSAKPLIRWLTAGDLPAAMEVLEEAFEGAERYWSTRLLGYLETLVAEIDGRVVGVAEIYETEARGYGRLGVVSYLAVKREFRRMGVGRSLVEAAEKIFRERGCAYVAASTRKSNKASQALFRKLGYELYERGSRVFEDLEGPLYAYRDDVVMLKKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0L3</accession>
    <name>A1S0L3_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1598"/>
    <dbReference type="EnsemblBacteria" id="ABL78993">
        <property type="protein sequence ID" value="ABL78993"/>
        <property type="gene ID" value="Tpen_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1598"/>
    <dbReference type="eggNOG" id="arCOG10989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393642_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="195" mass="22229" checksum="37F73FAF4B84BCCB" modified="2007-02-06" version="1">MLIPLFGLFKLFAKYYIRWAIVELTVIEGFKPECLAILEEAACKFYTALARKVKDPRLSKALEVVGLESKNHYEIIVAFFGKPAGAEDCRRFFGEEGFRMVEEMLQVAERLSSGVEVSLEEVASLLERFNSVEKVAGEEIYSKLYSVLIAEECKGLASLLMRSIASQEDFHYKVVEEVARTLRREAQANRERCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0N2</accession>
    <name>A1S0N2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1617"/>
    <dbReference type="EnsemblBacteria" id="ABL79012">
        <property type="protein sequence ID" value="ABL79012"/>
        <property type="gene ID" value="Tpen_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1617"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="FRQSTKM"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="291" mass="32186" checksum="47782D4C74D2D3AF" modified="2007-02-06" version="1">MGEGRKLVERLIIFAGSAILLLWIVIPTFWAFKTSISTPEEAWKPLPTKITLDNYLSLFNPSLEAILRGMGIRAALPDPMIVYIRNSLIVSLLASTIGVILGSLAGYNLARFDYKGKRVVTWLVLFAYVFPVFILIVPVLIIVRNLGLYNTLHGLALVHLAYTLPYSTLMMRSYFYGIPRVLEEAALIDGCTRFEALWRVVIPVSVPGFITAFIFSFTLSWNDLLFALVLLSSSRNYTLPIATTFFLWGGEIVDPGGLAATAIFAGLVPSVLYMLVQKYVVAGLIRGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P6</accession>
    <name>A1S0P6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formate dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753291.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1631"/>
    <dbReference type="EnsemblBacteria" id="ABL79026">
        <property type="protein sequence ID" value="ABL79026"/>
        <property type="gene ID" value="Tpen_1631"/>
    </dbReference>
    <dbReference type="GeneID" id="4600910"/>
    <dbReference type="KEGG" id="tpe:Tpen_1631"/>
    <dbReference type="eggNOG" id="arCOG01491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_2"/>
    <dbReference type="OMA" id="CPLDCPD"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="647" mass="71315" checksum="80260FD93ECCD979" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0R7</accession>
    <name>A1S0R7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753312.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1652"/>
    <dbReference type="EnsemblBacteria" id="ABL79047">
        <property type="protein sequence ID" value="ABL79047"/>
        <property type="gene ID" value="Tpen_1652"/>
    </dbReference>
    <dbReference type="GeneID" id="4601729"/>
    <dbReference type="KEGG" id="tpe:Tpen_1652"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OMA" id="HPYAKML"/>
    <dbReference type="OrthoDB" id="121018at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19391" checksum="3D826016B904380A" modified="2007-02-06" version="1">MSTAEKLPCADFLLSRRSVRKFSDEPVPDELIYRAIDIARFAPSAHNAQPWSFLVVKDREKLEKLAKIHRWSKPIANSKVAIIVFSDEKVSPKSHLVDGAIVATYLWLALHCLGLSTVWIYTLEQAEEIRRIVNAPPHLFPVAIFPVGFPAESPPPRPRRSLEELVHVDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S8</accession>
    <name>A1S0S8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1663"/>
    <dbReference type="EnsemblBacteria" id="ABL79058">
        <property type="protein sequence ID" value="ABL79058"/>
        <property type="gene ID" value="Tpen_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1663"/>
    <dbReference type="eggNOG" id="arCOG02462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_2"/>
    <dbReference type="OMA" id="GHPTHKT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="220" mass="24003" checksum="A7AB880125184D8D" modified="2007-02-06" version="1">MRKVYRLSPMRIVDLTMELKTGAPVFPGYPVPIVHTWTTIKEHGYYSNLLMLVEHTGTHVDSPAHFIEGAPTIDKVPLERFMGRGIVVDASHLPPKAPITREFLEKALEGKGVGNGWVVLIRTGYDAKAGTPDWFNHPGLDEGGARYLADLGVNAVGIDAPSIDQAPFPGHKILLPKGIVIFENLTNLGELLGKTFQFYGPPLRITNGSASPVRAFAVLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T1</accession>
    <name>DAPAL_THEPD</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized DapA-like lyase Tpen_1666</fullName>
            <ecNumber>4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dapAL</name>
        <name type="ordered locus">Tpen_1666</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753326.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1S0T1"/>
    <dbReference type="SMR" id="A1S0T1"/>
    <dbReference type="STRING" id="368408.Tpen_1666"/>
    <dbReference type="EnsemblBacteria" id="ABL79061">
        <property type="protein sequence ID" value="ABL79061"/>
        <property type="gene ID" value="Tpen_1666"/>
    </dbReference>
    <dbReference type="GeneID" id="4601248"/>
    <dbReference type="KEGG" id="tpe:Tpen_1666"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="YYGYGGF"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000340998" description="Uncharacterized DapA-like lyase Tpen_1666">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="301" mass="33347" checksum="6E7216012DC4BFF7" modified="2007-02-06" version="1">MSARFYGVISPFITPFREDLSLDREAVAWLARYQAEKGVHGIFPNSTTGEFVHLSREEAVEVTRLVLEAVGGKVWVIPGISANYTEDSVALGRTFKDLGVDGAVVTPPYFFKVSPERLKVHFSTILEKVDLPIIVYNIPATTGINIPVGLYLELAKEHSNLAGAKATVESFTYFRQLVQVVKAERKDFAVLTGLDDLLLPVLMMGGDGGIMALANAAPQIHREVYDAYRSGDLKRALEAWHKLLRLVRVYDYATSFPTSVKTLLKVMGAPVKPYARTPLTPETREVEEKIAQIARELGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0V2</accession>
    <name>A1S0V2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1687"/>
    <dbReference type="EnsemblBacteria" id="ABL79082">
        <property type="protein sequence ID" value="ABL79082"/>
        <property type="gene ID" value="Tpen_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1687"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_1_2"/>
    <dbReference type="OMA" id="NWACFKA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="136" mass="15626" checksum="FE4878D9318205B3" modified="2007-02-06" version="1">MLDSPEYERWMETARRTLSSARGDLERGDYNWACFKAQQAAEFAVKALLYGLGLPHHGHSVSRLLRVMPGGISVPQDVMQAAITLDKYYVPTRYPNAWHEGIPAEYYSRMDAEEAIRHAEEIVRWVERSWRSLKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0X1</accession>
    <name>A1S0X1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79101">
        <property type="protein sequence ID" value="ABL79101"/>
        <property type="gene ID" value="Tpen_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1706"/>
    <dbReference type="eggNOG" id="arCOG03744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145188_2_0_2"/>
    <dbReference type="OMA" id="RIKARIW"/>
    <dbReference type="OrthoDB" id="123404at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="111" mass="12057" checksum="09B10151D0EF90FE" modified="2007-02-06" version="1">MCNLRDRSRCAGFELLVDTGSMYTWIEGGRLRGLGIEPTGRRVFGTIGGRVVEREIGEAVIGCMGERATCIVVFAREGDAEVLGVTALENLALEVDPTTKQFRRVEAVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y9</accession>
    <name>A1S0Y9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1724"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79119">
        <property type="protein sequence ID" value="ABL79119"/>
        <property type="gene ID" value="Tpen_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1724"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_2"/>
    <dbReference type="OMA" id="APSRAVX"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="383" mass="42988" checksum="72498F556EE4FC07" modified="2007-02-06" version="1">MRETRIIFLTDYLTTKSGGVGFLYEVMKKIAGKYRIDIIAGRVEESLQKEDYVRILNLNVYRDDLPSAQPENAVKFLNLSTKMLKRIVKCTGEEELILHFNNHFPNLIPWFIVNSVPKVCSIHHLEETAQFSGVIPKLAKVAVQDVFEVNSPCTVVLTVSKSVRQKLASLRAVRKGGIVVIPPGIDTGKYLSVRRDPEENTFIMVGRLEKRKHYDHAIVAFKAVAKAEPNAKLLIVGEGPLRPYLAQLIRKFSLVRNVQLLGSVSEEEKLSLLSKAQALIHLGYPEGFGIVLIEALAAGVPVIAYDIPPLNEVVEHGATGILVPKDDVRVLARAIVRFNSYTFEEKTLRKRAERYDINIIAREFARLYDTLACCRRNNAGSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Z0</accession>
    <name>A1S0Z0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753385.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1725"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79120">
        <property type="protein sequence ID" value="ABL79120"/>
        <property type="gene ID" value="Tpen_1725"/>
    </dbReference>
    <dbReference type="GeneID" id="4601750"/>
    <dbReference type="KEGG" id="tpe:Tpen_1725"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803199_0_0_2"/>
    <dbReference type="OMA" id="HEVWGDY"/>
    <dbReference type="OrthoDB" id="75045at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="354" mass="40207" checksum="969D81A3E69BC933" modified="2007-02-06" version="1">MKVCFVCSHLWPHSYGGAERRYYILAKELMKRGHDVVYVTYDYGESEIPLATVGPPPRLYDEKGRRRLLPALEFGWKTAKLVEKLKCDVVDVTVPYTTALFMKPRSFVLTYHEYWGKYWEHYFSKPLGTLAAIAEKRLLRKAVLVITPSKLVANRILSEVGTVKVAPVPIGLNPDDYAKYRGRSRDIDVTMIGRFTYTKGWWRLIEVLRQVDKPLRVAVVGDGPLYNEVTAQLEKLHHEVHSYRKASEEEKLELLARSKYYLNLSDAEGFSIATLEAILCGATPIVLDTGLNAAVEIVEETGCGYIAKNLREIAEQVAKETSTCTPNISGYTIQTFVNNYLRFLGELQTMRVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S100</accession>
    <name>A1S100_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753395.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1735"/>
    <dbReference type="EnsemblBacteria" id="ABL79130">
        <property type="protein sequence ID" value="ABL79130"/>
        <property type="gene ID" value="Tpen_1735"/>
    </dbReference>
    <dbReference type="GeneID" id="4601760"/>
    <dbReference type="KEGG" id="tpe:Tpen_1735"/>
    <dbReference type="HOGENOM" id="CLU_179865_0_0_2"/>
    <dbReference type="OrthoDB" id="131357at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="90" mass="10460" checksum="59178C9F5124F577" modified="2007-02-06" version="1">MREPLFEVTSKLGVRVRVSRGYWEYIVSIKHPSLKGLEGVVREALANLLEVRRSPRDPRVYLYYGTYMDKLICVVVKHLNSEGFIITAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1S128</accession>
    <name>A1S128_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0251 protein Tpen_1763</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0251 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753423.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1763"/>
    <dbReference type="EnsemblBacteria" id="ABL79158">
        <property type="protein sequence ID" value="ABL79158"/>
        <property type="gene ID" value="Tpen_1763"/>
    </dbReference>
    <dbReference type="GeneID" id="4601940"/>
    <dbReference type="KEGG" id="tpe:Tpen_1763"/>
    <dbReference type="eggNOG" id="arCOG02238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094511_2_0_2"/>
    <dbReference type="OMA" id="PQVRHFY"/>
    <dbReference type="OrthoDB" id="77586at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00674">
        <property type="entry name" value="UPF0251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002852">
        <property type="entry name" value="UPF0251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37478">
        <property type="entry name" value="PTHR37478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02001">
        <property type="entry name" value="DUF134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="116" mass="12627" checksum="F129946AC486583C" modified="2007-02-06" version="1">MPGHGWCYRHRRGRIGRPPKPVSVGFLPSVQGFNPYPPPPLPIEPVVLEPAEVEALRLVDLEKLSYEEAGARMGVSRTTVWRLVESGREKLVSAILEGRPIVIAQLPGAPGETGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1S131</accession>
    <name>A1S131_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide dehydrogenase (Flavoprotein) subunit SudA</fullName>
            <ecNumber evidence="2">1.97.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.97.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1766"/>
    <dbReference type="EnsemblBacteria" id="ABL79161">
        <property type="protein sequence ID" value="ABL79161"/>
        <property type="gene ID" value="Tpen_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1766"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OMA" id="DRANMPG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="331" mass="35291" checksum="C22C1A74A2299DFD" modified="2007-02-06" version="1">MPIKFLTCNQPAPETGKKVAIVGSGPAGLAAASVLRCLGHKVDVFDRLPEPGGMLMFTIPEFRIPKKDVRESIKAIAGIGVSFYTDTEAGRDLKVEELLEDYDAVVISTGTWKGRSLGIPGENKGRVYNALDWIYHFMSYKLGYASSPPPPLEGRVGIVGAGLTAVDVAELAVHEYGAKPILLYRRPMSVAPAKHMLKHLEELGVQFIENVVPVEVVGGDSISGLKLARVKPTTSRTAATEVIPGSEFVIELDSLVAAVGLQPTPPPGLQSLGVELNRDGSIKVDENFMTSVKGLFAAGDVAHGPSNIGLAMRSGRLAAQKVSEWLLRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1S141</accession>
    <name>A1S141_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_1776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753436.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1776"/>
    <dbReference type="EnsemblBacteria" id="ABL79171">
        <property type="protein sequence ID" value="ABL79171"/>
        <property type="gene ID" value="Tpen_1776"/>
    </dbReference>
    <dbReference type="GeneID" id="4601937"/>
    <dbReference type="KEGG" id="tpe:Tpen_1776"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_2"/>
    <dbReference type="OMA" id="IQKYPAT"/>
    <dbReference type="OrthoDB" id="55143at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="282"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="383" mass="40907" checksum="58017F0A0889BC04" modified="2007-02-06" version="1">MSVWRLALKFVERDILFKKLIAALTILAIASGVATFVSLRILSLGSRTAAMNIVQQVLPGEVVVYGQGLYDVSEDVLSDIKRLPGVKDVTPAILVTGYVGRNAVFLLGVRPEDIKNVVSRFVDGQPFTGLTGAYAIADVGLARKLGLKVGDKVTVKPPYGTYFKQYEVVGIAEVAMKIEEIGAAGGYLILPLREAQNLLGRPGYVSMAVVKVEDGVDPQEVKTLISLVYPGSRVMLREEVIGVVFKVMSLIEGLLLSTTLVGLAVAVFGTTSTITSTVREHQREIAIMRAGGSSRRDIALIFMLESLVYGVSGGILGIVFGIVGAQVGIEVVSSYGFLNPPLILEPATLLLGFLLAAGLSVLSSLYPVWKATSIRPVEVLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S144</accession>
    <name>A1S144_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753439.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1779"/>
    <dbReference type="EnsemblBacteria" id="ABL79174">
        <property type="protein sequence ID" value="ABL79174"/>
        <property type="gene ID" value="Tpen_1779"/>
    </dbReference>
    <dbReference type="GeneID" id="4601923"/>
    <dbReference type="KEGG" id="tpe:Tpen_1779"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_3_2"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="OrthoDB" id="62488at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="258" mass="27133" checksum="B4F2D13F0619ECE1" modified="2007-02-06" version="1">MLREVGLALPGDPVLASLAMGLFVAFTTSLGAVPVLFGKKAWRHFTLALSFSAGVMLVSSFTSLILPALEATRSFALVSSGILLGVLAIMAVDRLVPHEHLLKGYEGPPEGRRLLKKSWLIALAVIIHNIPEGLAVGTSIAYSVPLGVATGLAIGLQDIPEGFAVAFPMAQVAGPRKGLAYGVLSGLSETLMAVLGAYFFTVFSALLPIGMSFSGGAMLYVTVKEVVPEIYREQSGEYAATAGFLLGFLLMLFLDSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>A1S159</accession>
    <name>A1S159_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753454.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1794"/>
    <dbReference type="EnsemblBacteria" id="ABL79189">
        <property type="protein sequence ID" value="ABL79189"/>
        <property type="gene ID" value="Tpen_1794"/>
    </dbReference>
    <dbReference type="GeneID" id="4601917"/>
    <dbReference type="KEGG" id="tpe:Tpen_1794"/>
    <dbReference type="eggNOG" id="arCOG00166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_2_2"/>
    <dbReference type="OMA" id="EVGVAMM"/>
    <dbReference type="OrthoDB" id="109660at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="218" mass="23254" checksum="D8F273EDB323307A" modified="2007-02-06" version="1">MDAGELAQITLLSLRVSLTAVSLSTLVGVFLGSLIATSSSKYKNALVTLVNTFMGTPPVLLGLVLYLLLSRSGPLGFLGMLFTPEAMVLAQFLLTLPIITGLTISAVESLPSELREFVKSISPSRLHESVLLLNESRIGVFGAVLAALARAVSEVGAVIIVGGNIRYYTRVLTTAIVYYTNTGEFETSLWLGATLTAIYLAINVVLVYVRTRLGARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1S174</accession>
    <name>A1S174_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1809"/>
    <dbReference type="EnsemblBacteria" id="ABL79204">
        <property type="protein sequence ID" value="ABL79204"/>
        <property type="gene ID" value="Tpen_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1809"/>
    <dbReference type="eggNOG" id="arCOG01310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050811_0_0_2"/>
    <dbReference type="OMA" id="LWATGNY"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="396" mass="43214" checksum="397014F665C587C9" modified="2007-02-06" version="1">MISMSNRNLLLVLVALFVLVALAGNVAAQPVTIAVDLGHGESNKYLKYIMGNITYVQWKVINGTITPDVLKGVDILLLGQPTVAFSPDEIQAIKNWLFSGNKVLYVGGDSDYGPGQKTVLQLNDLLAGIGTKLRLEHGAVYSDNPNMTAKAYYRMLAFVEPDNVPGLFTNIIKQGITRPIIMHGPGCVIWQDAQGKYHDPVKETFPGLIRIVWAHKAYIGDNTPPLPYVYDPMTYGKGTGDHDFVMYAAEYFSDVNSLVVVAGESLYGDYEPAWSSYYYGVQLDGPLFVQNLVKWWIKLLTTGPIERKVVDLSNTVSSLTSTVNQVSSQVSSQGGLIQKMQGDLQTVKSDVNTLKASVDALTGTVNLLTVLVIVEAILIIALIALLFLKKPKAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1B7</accession>
    <name>A1S1B7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751372.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL79247">
        <property type="protein sequence ID" value="ABL79247"/>
        <property type="gene ID" value="Tpen_1852"/>
    </dbReference>
    <dbReference type="GeneID" id="4600329"/>
    <dbReference type="KEGG" id="tpe:Tpen_1852"/>
    <dbReference type="HOGENOM" id="CLU_1080189_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="257" mass="29920" checksum="095A5D8E5CCF9E48" modified="2007-02-06" version="1">MPRPKKLRNAKVVPLVLEGELYEQAKRIAAQLGVSVSEYVRQALKEKIEADSVRLGLSNVFEEKAVAQARDGSLTAEVAGVPPLAVAQFNDFARSWEELRPALAKAVDEVKMLWGEWQGLDEEARHYAEKEVPPHLHDKWVKVEGRGEMWGRQAFQAFVEEYKAKRMKELAGRLREVDAVISRYWKLYYVWMKLRKEVFRDDNKDKEMLSRAAKIEAELARMYERIAEVRKEREELRRALYGSQKKGRRGFSTARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1C1</accession>
    <name>A1S1C1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="3">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751376.1">
        <property type="nucleotide sequence ID" value="NC_008696.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1856"/>
    <dbReference type="EnsemblBacteria" id="ABL79251">
        <property type="protein sequence ID" value="ABL79251"/>
        <property type="gene ID" value="Tpen_1856"/>
    </dbReference>
    <dbReference type="GeneID" id="4600342"/>
    <dbReference type="KEGG" id="tpe:Tpen_1856"/>
    <dbReference type="HOGENOM" id="CLU_1736511_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="150" mass="18234" checksum="5412B2BEC6209F59" modified="2007-02-06" version="1">MKREDWEVIEEDEEIVEEEEEPVEEEVVEEDEERVNEPDEVVIAKPEPSLESYMTRTELFLMHVYETKRYFNMSQEAKRRGMKQLASRFLRESRQHLRVAFHMCPYRPHMCPLYDVWTGKCPVGLEDRCRPLAWSKARPKKIRGWFRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1S1D8</accession>
    <name>A1S1D8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTPEN01</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
            <plasmid evidence="2">pTPEN01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000506">
        <property type="protein sequence ID" value="ABL79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1873"/>
    <dbReference type="EnsemblBacteria" id="ABL79268">
        <property type="protein sequence ID" value="ABL79268"/>
        <property type="gene ID" value="Tpen_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1873"/>
    <dbReference type="HOGENOM" id="CLU_3003358_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Plasmid pTPEN01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="56" mass="6639" checksum="8C84760083742916" modified="2007-02-06" version="1">MLELAVIKELQELRKELKDTVKEAIKEALREAIEELLQDPEVKQLVRDFLADVREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWE8</accession>
    <name>A1RWE8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751793.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0118"/>
    <dbReference type="EnsemblBacteria" id="ABL77528">
        <property type="protein sequence ID" value="ABL77528"/>
        <property type="gene ID" value="Tpen_0118"/>
    </dbReference>
    <dbReference type="GeneID" id="4601607"/>
    <dbReference type="KEGG" id="tpe:Tpen_0118"/>
    <dbReference type="eggNOG" id="arCOG00891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_5_2_2"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="48998at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="276" mass="30932" checksum="CE00B931C7305D1C" modified="2007-02-06" version="1">MIDAHCHLTYPGLKERVENVLAEARRALKAVVTSGLPYDAEKSPGFPGAKEALALSERYRGFVFVTLGLHPTQVPEMSDEEVAEYINFIEENRDRIVGIGEIGLDKYWLSSEDDLKRAREVFLSLLEVAEKLGKPVVIHSRKAEEEAVEILSSYSLDGRVLLHSFTGNMTTAKKALDMGYFFSINYKVTNTKSMRKIAKTFPLESILTETDSPFLSHEAGVNTPLQVRLILEEISRLRGLGFEEVDAITTRNAVSFFGLEKQTSERTSDKSLPRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWF6</accession>
    <name>A1RWF6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine and other phosphorylases, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751801.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0126"/>
    <dbReference type="EnsemblBacteria" id="ABL77536">
        <property type="protein sequence ID" value="ABL77536"/>
        <property type="gene ID" value="Tpen_0126"/>
    </dbReference>
    <dbReference type="GeneID" id="4602188"/>
    <dbReference type="KEGG" id="tpe:Tpen_0126"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_1_2"/>
    <dbReference type="OMA" id="FAMIADF"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="242" mass="25998" checksum="A49E6D965FE857F4" modified="2007-02-06" version="1">MFRHPLSKKVYHIKASPEQVSPKILVCGDPGRVEAASSLLDGATVVNRHRGYLVVTGEYRGERVTLATHGIGAPSAAIVFEELAMLGAKVMIRAGTCGGLTPIAESGKIALIEAAAYENSGTLYQYFGGVSMPAYATPEVVLTLESVLREKGLSFVRGIALSHDAFHKVEENARRWASLGVDFLEMESATLFALGRLRGVKVGAMALVVDNLLSGSELVEGREELELKMVEAGLEALRRMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWI3</accession>
    <name>A1RWI3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0153"/>
    <dbReference type="EnsemblBacteria" id="ABL77563">
        <property type="protein sequence ID" value="ABL77563"/>
        <property type="gene ID" value="Tpen_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0153"/>
    <dbReference type="eggNOG" id="arCOG00075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743183_0_0_2"/>
    <dbReference type="OMA" id="VEDIPWP"/>
    <dbReference type="OrthoDB" id="50942at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="40262" checksum="A12A36EF7B75FC83" modified="2007-02-06" version="1">MEKYPFLSPSGRRGYVRSFSDYIEVEYEGEPSSLYLWSQGSGSLYRGSTGFFKSVYEPPLAEKGWSTEAPVEDRVAEVARRHGEKLKGKHVMADLSGGKDSTANLYLLTKLQEIVGFKVTAVYVHMPYLEPVENIAFAEKVASRLGVDLRIVEPDRRKLEFYLLREGLPKRGDRWCTYLKTRALREAKKEIGAEVEAKAERALEAGKRYERLSGLAKRKVYFNGGVVNLVHDLSAAEVAGIVRRAGLVHPHYLQGLPRVSCRFCPYRGLYELEVSSKHEVEDEGLVEWVMARTYRNYYSSVTPLETFLELHLWRYTPSVARLRVLEAGYVDPDSKISLSEARKMFSWIWVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWL7</accession>
    <name>A1RWL7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Respiratory-chain NADH dehydrogenase, subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751862.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0187"/>
    <dbReference type="EnsemblBacteria" id="ABL77597">
        <property type="protein sequence ID" value="ABL77597"/>
        <property type="gene ID" value="Tpen_0187"/>
    </dbReference>
    <dbReference type="GeneID" id="4600800"/>
    <dbReference type="KEGG" id="tpe:Tpen_0187"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_2_1_2"/>
    <dbReference type="OMA" id="PWYQNFI"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="312" mass="33966" checksum="5D4E80208682FA0C" modified="2007-02-06" version="1">MIPLQILVGVVQGVCLVLLAPLAYGIQRKIIARLQLRKGPPVIQPYRDLLKLWSKDKLSVPEVSSWIYMATPLLYLAITVVIAMSIPVFVNMGIPLADIFLLIYSLALARFVLSIASLDTGSPLAAAGAWRENAAAVVIEVPMLFAALLPALEGGSSSLYAVVSHTCLRWETFIARPSYIVAALAFFVCMLAEAGVLPFDVAEAEQEIQEGLLQEYSGRQLALMQLSMMVKRAVLFTLFVDIFLPYGVALTLEPLGILVGVASYLIKLLALVTIAALVIAGNARYKVVELHKNLSLVFVLVVCATIFYLMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWM0</accession>
    <name>A1RWM0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate dehydrogenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751865.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0190"/>
    <dbReference type="EnsemblBacteria" id="ABL77600">
        <property type="protein sequence ID" value="ABL77600"/>
        <property type="gene ID" value="Tpen_0190"/>
    </dbReference>
    <dbReference type="GeneID" id="4600623"/>
    <dbReference type="KEGG" id="tpe:Tpen_0190"/>
    <dbReference type="eggNOG" id="arCOG01491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_2"/>
    <dbReference type="OMA" id="NVGTDIP"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL77600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="685" mass="75808" checksum="C3B6DE4B6FA2AA75" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWN1</accession>
    <name>A1RWN1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751876.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0201"/>
    <dbReference type="EnsemblBacteria" id="ABL77611">
        <property type="protein sequence ID" value="ABL77611"/>
        <property type="gene ID" value="Tpen_0201"/>
    </dbReference>
    <dbReference type="GeneID" id="4602212"/>
    <dbReference type="KEGG" id="tpe:Tpen_0201"/>
    <dbReference type="eggNOG" id="arCOG01141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_4_0_2"/>
    <dbReference type="OMA" id="IHCGDFV"/>
    <dbReference type="OrthoDB" id="78782at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="168" mass="18389" checksum="DC64F33937D5A892" modified="2007-02-06" version="1">MARVAVVSDSHDSLEAIRLFVNSLKNENVEAVIHAGDIISPFALRMFSGYRLYAVFGNNDGEKLLLKKTADEIGAVLSEQPMLVRVGSFDIAVLHGVDGLDVSRRLARALAKSGEFRLVVYGHTHRVDVERIGDALVVNPGTLSGYLAEKRTFAIVDLEKLEAEIVEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWQ7</accession>
    <name>RL2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl2</name>
        <name type="ordered locus">Tpen_0227</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751902.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWQ7"/>
    <dbReference type="SMR" id="A1RWQ7"/>
    <dbReference type="STRING" id="368408.Tpen_0227"/>
    <dbReference type="EnsemblBacteria" id="ABL77637">
        <property type="protein sequence ID" value="ABL77637"/>
        <property type="gene ID" value="Tpen_0227"/>
    </dbReference>
    <dbReference type="GeneID" id="4601217"/>
    <dbReference type="KEGG" id="tpe:Tpen_0227"/>
    <dbReference type="eggNOG" id="arCOG04067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_1_2"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="74812at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000310059" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="248" mass="26572" checksum="C9AA8891AB4516EB" modified="2007-02-06" version="1">MGKRLLVQRRGRGGSVFRNPGWKRLGPARYPPYNPEEFKNKVLVGVVKDLLHEPGRGAPLALVEFEDGTKMYMIPPEGLAVGQKIYYGAKAPAVLGSIVEIGNVPEGTIVSNIEIRPGDGGKLARSSGAYALVLAHSNGKTLIQLPSKKVKEVSSEARATIGMVAAGGRIEKPMLKAGKMWHWSRAKSFKYPTVRGKAMSAYAHPAGGGHHPKGLTPAPRNAPPGRKVGHIAPRRTGRKKGASRTPTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWR6</accession>
    <name>RS5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps5</name>
        <name type="ordered locus">Tpen_0236</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751911.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1RWR6"/>
    <dbReference type="SMR" id="A1RWR6"/>
    <dbReference type="STRING" id="368408.Tpen_0236"/>
    <dbReference type="EnsemblBacteria" id="ABL77646">
        <property type="protein sequence ID" value="ABL77646"/>
        <property type="gene ID" value="Tpen_0236"/>
    </dbReference>
    <dbReference type="GeneID" id="4600706"/>
    <dbReference type="KEGG" id="tpe:Tpen_0236"/>
    <dbReference type="eggNOG" id="arCOG04087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="60954at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000293220" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="202" mass="22178" checksum="B3C38568C30CA975" modified="2007-02-06" version="1">MSGEWQPRTLLGRLVVEGKIKSIDEVFARNMPIREVEIIDTLLPGLKSEVLSVGFVQRQTDSGEVSQYQVTVAVGNEDGYVGVGMGKSRQIGIAIEKATRRAKLNIVPVRRGCGSWECLCGEPHSIPFKVEGKAGSVKIELIPAPKGVGLVASDVAKTVLRLAGIKDVWSRSYGETRTTHNMAKAVYEALKKTYQFYSPDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWS7</accession>
    <name>A1RWS7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein Tpen_0247</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011751922.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0247"/>
    <dbReference type="EnsemblBacteria" id="ABL77657">
        <property type="protein sequence ID" value="ABL77657"/>
        <property type="gene ID" value="Tpen_0247"/>
    </dbReference>
    <dbReference type="GeneID" id="4601474"/>
    <dbReference type="KEGG" id="tpe:Tpen_0247"/>
    <dbReference type="eggNOG" id="arCOG00928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_0_0_2"/>
    <dbReference type="OMA" id="LRLAHMI"/>
    <dbReference type="OrthoDB" id="103162at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="199" mass="22476" checksum="653C2568E90DE729" modified="2007-02-06" version="1">MLVSKPAFRVLGVAECFRKRARKSVIAGVVWRRDGFVDGVYLSFASVGGMDATDAIVDMYLRSSRRDINVIMLNGCIISWFNIADPEKIYERTGIPVICLSYEESEGLEKYIEKYFPGDVHRMRAYQSLGSRRLVYVKPARTYVYVRASGIAMDEVSRILNVTTKSGKVPEPLRVARQVARAVHSLLEREDPQLLGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RWX2</accession>
    <name>A1RWX2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phage repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_0292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0292"/>
    <dbReference type="EnsemblBacteria" id="ABL77702">
        <property type="protein sequence ID" value="ABL77702"/>
        <property type="gene ID" value="Tpen_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0292"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1943969_0_0_2"/>
    <dbReference type="OMA" id="WFPEPVI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL77702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="129" mass="13984" checksum="9DFDDB7823D0AF09" modified="2007-02-06" version="1">MAEDRREIVLYALTIVGLLVFLLSLRFVLSTPVPLAVVSSWSMEPVLHVGDVVVVAGGNSYTLGDIVIYERGGELIVHRIVLSVNGKYVTKGDANPQADNIVLGKDAIYGKVQIVIPYIGALKLIFYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX26</accession>
    <name>A1RX26_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0347"/>
    <dbReference type="EnsemblBacteria" id="ABL77756">
        <property type="protein sequence ID" value="ABL77756"/>
        <property type="gene ID" value="Tpen_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0347"/>
    <dbReference type="eggNOG" id="arCOG03260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427389_0_0_2"/>
    <dbReference type="OMA" id="GALNQPI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="642" mass="68761" checksum="4CC5ABEBD68E0FB3" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX28</accession>
    <name>A1RX28_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ordered locus">Tpen_0349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0349"/>
    <dbReference type="EnsemblBacteria" id="ABL77758">
        <property type="protein sequence ID" value="ABL77758"/>
        <property type="gene ID" value="Tpen_0349"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0349"/>
    <dbReference type="eggNOG" id="arCOG01885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176720_2_0_2"/>
    <dbReference type="OMA" id="TRDFEHN"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="95" mass="11211" checksum="709AAF23F69D4D96" modified="2007-02-06" version="1">MGNVRSKLVKRTAKMLVEQYPDAFTVDFELNKKKLMEIADIPSRQLRNQIAGYITRLVRRKKLIEQRLSMRQEITMTDEEEYIRRIEGFSTSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX37</accession>
    <name>A1RX37_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps8e</name>
        <name evidence="5" type="ordered locus">Tpen_0358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752032.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0358"/>
    <dbReference type="EnsemblBacteria" id="ABL77767">
        <property type="protein sequence ID" value="ABL77767"/>
        <property type="gene ID" value="Tpen_0358"/>
    </dbReference>
    <dbReference type="GeneID" id="4600896"/>
    <dbReference type="KEGG" id="tpe:Tpen_0358"/>
    <dbReference type="eggNOG" id="arCOG04154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_2_1_2"/>
    <dbReference type="OMA" id="NPNYVRR"/>
    <dbReference type="OrthoDB" id="116294at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="128" mass="13952" checksum="5EC3C0ED8B3A0CA9" modified="2007-02-06" version="1">MGIYHGNDLRKITGGIKGRHVKTKRKYLSGRYPILTVPGQATEVKVVKARGNTYKLKVKVASEVNVYIPKEGKTVRAQIIKVLDNPSNKDFARRGIISKGAILQTSVGKVKVTSRPGQDGVVNGVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX54</accession>
    <name>A1RX54_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gar1-like small nucleolar rnp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752049.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0375"/>
    <dbReference type="EnsemblBacteria" id="ABL77784">
        <property type="protein sequence ID" value="ABL77784"/>
        <property type="gene ID" value="Tpen_0375"/>
    </dbReference>
    <dbReference type="GeneID" id="4600775"/>
    <dbReference type="KEGG" id="tpe:Tpen_0375"/>
    <dbReference type="eggNOG" id="arCOG02466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165884_1_0_2"/>
    <dbReference type="OMA" id="SRWEPEA"/>
    <dbReference type="OrthoDB" id="115856at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10433" checksum="98CEEA32A284C0FE" modified="2007-02-06" version="1">MQLIGRARLYSRNKNLVVEASNVPPIGEKVYDEKAMLVGYVYDVIGPVTSPFVLVKVDESRWEPEALVGKLLYWSGNVGPTGGKLRTKKQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RX68</accession>
    <name>A1RX68_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0389"/>
    <dbReference type="EnsemblBacteria" id="ABL77798">
        <property type="protein sequence ID" value="ABL77798"/>
        <property type="gene ID" value="Tpen_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0389"/>
    <dbReference type="eggNOG" id="arCOG01042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131306_1_1_2"/>
    <dbReference type="OMA" id="CHATEDC"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="150" mass="17467" checksum="8744D372DAACEA3E" modified="2007-02-06" version="1">MLSLELSTFVHATEDEERVLQAVSNVLPERMRGSLEVYLSKNVVLGYHGNAITVMKFFIDEEVEAQEAFEHIVRRMEESDFNYFLDSLEDRFEHGRIYLRVDKQEAYLGNIRISEGDDVIRVTALLKPHLRKSEAVSRYLLSLRSKKTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXD9</accession>
    <name>A1RXD9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752134.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0460"/>
    <dbReference type="EnsemblBacteria" id="ABL77869">
        <property type="protein sequence ID" value="ABL77869"/>
        <property type="gene ID" value="Tpen_0460"/>
    </dbReference>
    <dbReference type="GeneID" id="4600987"/>
    <dbReference type="KEGG" id="tpe:Tpen_0460"/>
    <dbReference type="eggNOG" id="arCOG01239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514691_0_0_2"/>
    <dbReference type="OrthoDB" id="130963at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007158">
        <property type="entry name" value="TrmY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04013">
        <property type="entry name" value="Methyltrn_RNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="177" mass="19929" checksum="DA74EA972516E3CC" modified="2007-02-06" version="1">MRRVFNVVIPRSRFVDDVPLVCRVVTSAIFLSHDIRRDVTLRFVMPDAGLSVSFLSSRLRHVHVDEQSFAGLHRRIVRAMWEVESEGGARHPHSGISVERIAGNVEEQFGGSFLVSSDGELLADVLRRLGEVREISLVFSAGFQVRVPRRVRVSVERKNLDVLIVIANIEIDNYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXF4</accession>
    <name>A1RXF4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752149.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0475"/>
    <dbReference type="EnsemblBacteria" id="ABL77884">
        <property type="protein sequence ID" value="ABL77884"/>
        <property type="gene ID" value="Tpen_0475"/>
    </dbReference>
    <dbReference type="GeneID" id="4602034"/>
    <dbReference type="KEGG" id="tpe:Tpen_0475"/>
    <dbReference type="eggNOG" id="arCOG01359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533842_0_0_2"/>
    <dbReference type="OMA" id="HTPGKYL"/>
    <dbReference type="OrthoDB" id="19362at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="185"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL77884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="567" mass="62837" checksum="508DF62BC35B82EA" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI1</accession>
    <name>A1RXI1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_0504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752176.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0504"/>
    <dbReference type="EnsemblBacteria" id="ABL77911">
        <property type="protein sequence ID" value="ABL77911"/>
        <property type="gene ID" value="Tpen_0504"/>
    </dbReference>
    <dbReference type="GeneID" id="4601338"/>
    <dbReference type="KEGG" id="tpe:Tpen_0504"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_4_2"/>
    <dbReference type="OMA" id="LILEMAV"/>
    <dbReference type="OrthoDB" id="100198at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="44"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL77911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="152" mass="17637" checksum="BA19C86B80A503D2" modified="2007-02-06" version="1">MSDDTGKVAAELAEAIARIQKELNDSLREIWAKHFALYPDKLRMLDPLYDIEDRGDSLAVYVDLPGFRKNEIKIRVTEDSLEVFAEKSEERVKDEDSRKYIQRQRLYKQVYKKISLPVKVRPEQARARFEDGVLVVLVPKSGAEKEVEVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXI3</accession>
    <name>A1RXI3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752178.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0506"/>
    <dbReference type="EnsemblBacteria" id="ABL77913">
        <property type="protein sequence ID" value="ABL77913"/>
        <property type="gene ID" value="Tpen_0506"/>
    </dbReference>
    <dbReference type="GeneID" id="4601002"/>
    <dbReference type="KEGG" id="tpe:Tpen_0506"/>
    <dbReference type="eggNOG" id="arCOG09797">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024114_0_0_2"/>
    <dbReference type="OrthoDB" id="144493at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="472" mass="53676" checksum="1836CBB3FE896254" modified="2007-02-06" version="1">MVGEKMMGYEGVEGEVREETWRRAALSLYSTEVEDKRKGRVHYRGLYDTVSGINWDFTRFLVNGYSVVPDEVYSRFYRFIDYDLRKYLLLNDDEKPREGSAVTELRGRLQAIVDAGADGLRAEKKGKVWHVYIPGENWHVIAHKPTYDWIVHVPLEGFWTEASFPEVLARTSPDVLRSLQKGWVLTDVTPPHGRISDVRFATTQPWQLPSTLAAFPSDHVDVGVTAGVLGSTRMSIEWRANVYGYADELGWASRLIGEVKRVEFRRLVEECRALNGDSVALATAFLGDGELEYFLRLRWLYFRVGQEHIYLPAESAIINARLAVELAPEYTKFVSLVTRCAKIKHFLFVGFGAPQRRGRKNGQSPSPFYAEVAGARLVLVYISTKNNIYARIAVDGVPPGWYGRALEEGWDVRVVRMGSKEYYQVTHCSLFEHARYDAALRETLLAFAKAKAEQYPKAQSLVERLEKLGTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXK4</accession>
    <name>A1RXK4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752199.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0528"/>
    <dbReference type="EnsemblBacteria" id="ABL77934">
        <property type="protein sequence ID" value="ABL77934"/>
        <property type="gene ID" value="Tpen_0528"/>
    </dbReference>
    <dbReference type="GeneID" id="4601346"/>
    <dbReference type="KEGG" id="tpe:Tpen_0528"/>
    <dbReference type="HOGENOM" id="CLU_2695964_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="73" mass="8069" checksum="740C84C9DE8B3961" modified="2007-02-06" version="1">MEEREGPERRYIGKSVEAYLREQLARRLSEDPEALKLAYELLEAFATGGARGVRAVIEEKVRECGCTPAEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL0</accession>
    <name>A1RXL0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752205.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0534"/>
    <dbReference type="EnsemblBacteria" id="ABL77940">
        <property type="protein sequence ID" value="ABL77940"/>
        <property type="gene ID" value="Tpen_0534"/>
    </dbReference>
    <dbReference type="GeneID" id="4601047"/>
    <dbReference type="KEGG" id="tpe:Tpen_0534"/>
    <dbReference type="eggNOG" id="arCOG04275">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168009_0_0_2"/>
    <dbReference type="OMA" id="LYGLPMF"/>
    <dbReference type="OrthoDB" id="105902at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL77940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="128" mass="14385" checksum="419EE627B9935DFE" modified="2007-02-06" version="1">MASEEVRVEPILAVKLASINDLARLASSASTMGHVTYVVHFAETPERHIYGIFIVFRDYYKLYGLPMFYYIESKEELRGNYILFRSDDSGEQVEVSKGAKPGYIAIPIVNLAGRIPIVALGEVRQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXL4</accession>
    <name>A1RXL4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0538"/>
    <dbReference type="EnsemblBacteria" id="ABL77944">
        <property type="protein sequence ID" value="ABL77944"/>
        <property type="gene ID" value="Tpen_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0538"/>
    <dbReference type="eggNOG" id="arCOG00608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116133_0_0_2"/>
    <dbReference type="OMA" id="HYKAVMI"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="149"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL77944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="202" mass="22470" checksum="6897154C5F59388E" modified="2007-02-06" version="1">MLKMHRTYYFFGMPIPSPEELRLLRLRAGLTQVELAQRAGVSQSLIARIEAGKVNPRVSTLMKIYRALESFMEEELTACEVMSSPLVYVKPSTSLLEVARIMWEKGFSQLPVIDDSSNENLGTVFDDDVLRAFIRENTRAAQLTAADVMSDPLPIISCGTKIRVVARMLGRGVPAVLVEDEMKIKGIITKSDIAKLLVVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXP6</accession>
    <name>A1RXP6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate ferredoxin oxidoreductase, gamma subunit</fullName>
            <ecNumber evidence="3">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_0571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL77976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0571"/>
    <dbReference type="EnsemblBacteria" id="ABL77976">
        <property type="protein sequence ID" value="ABL77976"/>
        <property type="gene ID" value="Tpen_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0571"/>
    <dbReference type="eggNOG" id="arCOG01603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_2_0_2"/>
    <dbReference type="OMA" id="PDYVIVQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL77976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="183" mass="20082" checksum="346C26E889A9ABF1" modified="2007-02-06" version="1">MRWHGRGGQGVVTSSELLALAALREGKFVYHAPEFGPERRGAPVKAYTRISREPIELHSGIYEPSAVVVIDPSLQNDPSIASGLRKGGLIVVNAKSPGDVLLRSAQEKGAEVWYVDAYSIAMEVFGRPFYNTPMLGAFVRASNVVSLESVVSVAMERFSKDSKLAQLNVLAIRRAYDEVKKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXU6</accession>
    <name>A1RXU6_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priS</name>
        <name evidence="13" type="ordered locus">Tpen_0622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0622"/>
    <dbReference type="EnsemblBacteria" id="ABL78026">
        <property type="protein sequence ID" value="ABL78026"/>
        <property type="gene ID" value="Tpen_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0622"/>
    <dbReference type="eggNOG" id="arCOG04110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056123_0_0_2"/>
    <dbReference type="OMA" id="GYHVHVR"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABL78026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="389" mass="44512" checksum="429452BFCD6068E5" modified="2007-02-06" version="1">MHRASQSSAKSDMALIRGLFARYYARTSVEAPSELSKREFAFSMFNSTSMIRHLSFSTREELDDYIRVNVPQHAYYSSAYYQYPSAQEMGEKGWLGADLVFDIDVDHIPTPCKDLHDRWRCQDCGAEGWGFTKKCPSCGSERLEWSKWVCSTCINVAREEMIKLVEILEDDFGFDRAEMRVAFSGHRGFHLHVESEAVKDLDQDARREITDYVRGIGIDVKLYLKPAGKSLYTYKYSATSPGWAGRIAKYLLLRLLQAGENGELESLSMEYEQWEKTIKEAVSELSVKVDEKVTIDTKRLIRLPGSLHGKTGLKVFSMSVNELENLDSDSILKRAIVFPDEKVQVAIEKPPRKVLYYSLEKVEEGKLEVPLFLAVYMVLNGKARLLNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXW7</accession>
    <name>A1RXW7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752312.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0645"/>
    <dbReference type="EnsemblBacteria" id="ABL78047">
        <property type="protein sequence ID" value="ABL78047"/>
        <property type="gene ID" value="Tpen_0645"/>
    </dbReference>
    <dbReference type="GeneID" id="4601511"/>
    <dbReference type="KEGG" id="tpe:Tpen_0645"/>
    <dbReference type="HOGENOM" id="CLU_203625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="76" mass="8345" checksum="4158F49429756983" modified="2007-02-06" version="1">MSDPRVTVRTIGALSRLLASTLKGDGLYEARLVEALDAIEEFLTSVGSATPRVEEDEELERELEEGVEELRELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY1</accession>
    <name>A1RXY1_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ordered locus">Tpen_0659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752326.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0659"/>
    <dbReference type="EnsemblBacteria" id="ABL78061">
        <property type="protein sequence ID" value="ABL78061"/>
        <property type="gene ID" value="Tpen_0659"/>
    </dbReference>
    <dbReference type="GeneID" id="4601617"/>
    <dbReference type="KEGG" id="tpe:Tpen_0659"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_2"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="47919at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABL78061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="431" mass="47831" checksum="4751AF58A52657A9" modified="2007-02-06" version="1">MSKNLVLQPPRGTRDWLPEEAYAKRIVSEKIREVFESYGYGEVITPAFEYLDLLKAKAGEEVVEQIYAFKDKAGRELGLRFEMTTPIARIVASRLDLAKPLRFYYVQPVWRYEEPQRGRWREFWQAGIELFGISEPEGDAEVVAVTFDALKAVGLKDFDIRVNDRRVVEDLVLGAGIPGDLLPSALRVLDKMDKFGEEYVVSELAKLGLREDAATSLLEKLKSGSLDIDTSTQPGREGLRRLALVVDTLKNCYGINVTVDYAIVRGLGYYTGFVFEVKAGSSEGLGSIAGGGRYDDLVSVVGGPKIPASGMAIGVERLLEALSMQGALKLDYREVDVCVIPVKKTPEILSEAVAVARELRVAGMKVVLEVSERSLSKLLEAASKRGARFAIILGERELKEGVVTVRDLYLWKEEKVARPHLYEYIRAGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RXY8</accession>
    <name>A1RXY8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="4">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">top6B</name>
        <name evidence="6" type="ordered locus">Tpen_0666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TOP6B family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752333.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0666"/>
    <dbReference type="EnsemblBacteria" id="ABL78068">
        <property type="protein sequence ID" value="ABL78068"/>
        <property type="gene ID" value="Tpen_0666"/>
    </dbReference>
    <dbReference type="GeneID" id="4601624"/>
    <dbReference type="KEGG" id="tpe:Tpen_0666"/>
    <dbReference type="eggNOG" id="arCOG01165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006403_0_0_2"/>
    <dbReference type="OMA" id="TRIELEM"/>
    <dbReference type="OrthoDB" id="13565at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006553">
        <property type="entry name" value="TopoVI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="5">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="516" mass="58549" checksum="C9B96D3CCA1A7889" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYC8</accession>
    <name>A1RYC8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TackOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752473.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0807"/>
    <dbReference type="EnsemblBacteria" id="ABL78208">
        <property type="protein sequence ID" value="ABL78208"/>
        <property type="gene ID" value="Tpen_0807"/>
    </dbReference>
    <dbReference type="GeneID" id="4602138"/>
    <dbReference type="KEGG" id="tpe:Tpen_0807"/>
    <dbReference type="eggNOG" id="arCOG06883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917091_0_0_2"/>
    <dbReference type="OMA" id="VIYCENC"/>
    <dbReference type="OrthoDB" id="59263at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040572">
        <property type="entry name" value="TackOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18551">
        <property type="entry name" value="TackOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TackOD1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="327" mass="36289" checksum="398BC1962326870E" modified="2007-02-06" version="1">MAGGGTARLEASEVELLRNLARALQDLVVYLVESNLGEISIEIGKKDHPVKSIADKYRVPLDTLLEEGVKRGFLKAFPADKLVFCPKCGGFSFKVRYACPNCGSFDVERNTLFSHVTCGFIGVLEEAPRTVTGKVQCPKCKRELVREGDDWVKLSSTWRCRSCGTSFSYPVASLECASCGERFDDKRAEYRAVMRYSVDKKAVSEAFSQIFNKRVAEVLASQGYVVKPAAEATAMSGVTRKASLIAEKRGVRLYVHNIFPREGNVESAKDEVFNVYGSALDDATRRIIVAVNTPTQVARRPENVETIEGRSLEEAIRKLQEKLRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYD5</accession>
    <name>A1RYD5_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752480.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78215">
        <property type="protein sequence ID" value="ABL78215"/>
        <property type="gene ID" value="Tpen_0814"/>
    </dbReference>
    <dbReference type="GeneID" id="4601984"/>
    <dbReference type="KEGG" id="tpe:Tpen_0814"/>
    <dbReference type="eggNOG" id="arCOG15071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2353365_0_0_2"/>
    <dbReference type="OrthoDB" id="131380at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="92" mass="10273" checksum="E1422CE8E2B4FD7D" modified="2007-02-06" version="1">MPTMRIAAVVLPDLEKALKAGGADIVIAVNDPREAERRIEEIVREKAADLVLVDDVLVSMMGRGKLKELKYRYPYPAIIELETNRLRTPIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYG7</accession>
    <name>A1RYG7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752512.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0846"/>
    <dbReference type="EnsemblBacteria" id="ABL78247">
        <property type="protein sequence ID" value="ABL78247"/>
        <property type="gene ID" value="Tpen_0846"/>
    </dbReference>
    <dbReference type="GeneID" id="4600780"/>
    <dbReference type="KEGG" id="tpe:Tpen_0846"/>
    <dbReference type="eggNOG" id="arCOG04319">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122668_0_0_2"/>
    <dbReference type="OrthoDB" id="99991at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009198">
        <property type="entry name" value="UCP014484_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09973">
        <property type="entry name" value="DUF2208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="243" mass="27834" checksum="EE24B92FCFE30A5F" modified="2007-02-06" version="1">MSRALILQYLLGLVLMVLFAYMNANYPDKTWLFFILYFTAFMVIMMVVTGRHARSVLRDLEEVKSGEILYSSKPDEVLKLREKDFQLTQPELMAQFKASMIPLLSLVVFILVFYIPGFREFFTGLGKSMALDEKTANFLSFLALYGFFYAFSLATGLYARRLQSKTGSLIIATSYTVTSKGIIVDERTPVKFPWKGDIIVDSRRKFVQLNITQQIMGTSITQKIRLYNPEPSKLANILKSYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYH8</accession>
    <name>A1RYH8_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Tpen_0857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0857"/>
    <dbReference type="EnsemblBacteria" id="ABL78258">
        <property type="protein sequence ID" value="ABL78258"/>
        <property type="gene ID" value="Tpen_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0857"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OMA" id="AARTKNM"/>
    <dbReference type="OrthoDB" id="41678at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="6">
        <location>
            <begin position="16"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="7">
        <location>
            <begin position="211"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="8">
        <location>
            <begin position="471"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="569" mass="61721" checksum="E5064ED609A6FCC7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYK9</accession>
    <name>A1RYK9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase, DHHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752554.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0888"/>
    <dbReference type="EnsemblBacteria" id="ABL78289">
        <property type="protein sequence ID" value="ABL78289"/>
        <property type="gene ID" value="Tpen_0888"/>
    </dbReference>
    <dbReference type="GeneID" id="4600831"/>
    <dbReference type="KEGG" id="tpe:Tpen_0888"/>
    <dbReference type="eggNOG" id="arCOG00423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862273_0_0_2"/>
    <dbReference type="OrthoDB" id="117010at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="35396" checksum="7608E5B01B9ADADE" modified="2007-02-06" version="1">MRIYAFVLHGDLDGLSATATVAAALKHAEKDAELRFYFSQPYELDKDLARVDPRAEGIYIVDLAIDADVWPRLSAELGKLVASKRVTWIDHHPSTIERVEELKRIGVEAMLAEAASASTIARSFLDRVPDPAFFEKIITIGEVADRAVSVAREDPLFHYVEVLSLVLGYRVRDEQIRRRILRAWITERVVVPDEVAKAASEAEKVFQDLLREARLRVVYRSEKVVAVDMRDKRVYGFAGMLASIIASEEGRIALILSRVGEAALLTLRAPPGAKGNPSKTAWDVASRYGGSGGGHAGAASFKVPGTYAEKVLAEIVRALETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYN7</accession>
    <name>A1RYN7_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="5">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_0916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752582.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0916"/>
    <dbReference type="EnsemblBacteria" id="ABL78317">
        <property type="protein sequence ID" value="ABL78317"/>
        <property type="gene ID" value="Tpen_0916"/>
    </dbReference>
    <dbReference type="GeneID" id="4600812"/>
    <dbReference type="KEGG" id="tpe:Tpen_0916"/>
    <dbReference type="eggNOG" id="arCOG04184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="94889at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="187" mass="20543" checksum="51E046FAEBF8BB7F" modified="2007-02-06" version="1">MRVYVVTGNVHKVAELSLALKPFGVELEPLRAEKLEVQSESLEKIALVAAEHLPPLDKPAIVEDAGLFVKALNGFPGPYSSYAYKTIGCRGLLKLMEGVSDREAVFRSVIALRMPDGSIHLFKGEAAGVITEEERGTGGFGFDPVFRPRGSEKTFAEMTTEEKNLYSHRAKAARNLAEWLVRRAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYT0</accession>
    <name>A1RYT0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752625.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0960"/>
    <dbReference type="EnsemblBacteria" id="ABL78360">
        <property type="protein sequence ID" value="ABL78360"/>
        <property type="gene ID" value="Tpen_0960"/>
    </dbReference>
    <dbReference type="GeneID" id="4600764"/>
    <dbReference type="KEGG" id="tpe:Tpen_0960"/>
    <dbReference type="eggNOG" id="arCOG07346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393059_0_0_2"/>
    <dbReference type="OMA" id="RRSNINQ"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="93" mass="10898" checksum="074589E33F053EAD" modified="2007-02-06" version="1">MTERSYRYRQVKFNLKEEEYAKLESLAKEIGTTPAALAKKIVLEHLGLDESVTLIERVRTLEERYERMAKELGRIEKDLAYVIRVIRAKRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU2</accession>
    <name>A1RYU2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaREP8 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752637.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0972"/>
    <dbReference type="EnsemblBacteria" id="ABL78372">
        <property type="protein sequence ID" value="ABL78372"/>
        <property type="gene ID" value="Tpen_0972"/>
    </dbReference>
    <dbReference type="GeneID" id="4600446"/>
    <dbReference type="KEGG" id="tpe:Tpen_0972"/>
    <dbReference type="eggNOG" id="arCOG03721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115256_0_0_2"/>
    <dbReference type="OMA" id="SQKLGDW"/>
    <dbReference type="OrthoDB" id="104108at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010268">
        <property type="entry name" value="PaREP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05942">
        <property type="entry name" value="PaREP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19071" checksum="9B103E30AE9B5B0D" modified="2007-02-06" version="1">MHAPITIPERLVKEAVKKGLDIEASAVDPAKTLNTDPSAEARLELAEKSLGEAEEYLAKGDVVQASEKLYKAVEECVKALAEKLGAKQAEEARRRGRWDTWLLGMAATDLARTLGEDRVRLAWKDAYDVHVWGFHEAKYRVEDVEAALPLARWLLDYAAKIVKAEVSNRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYU4</accession>
    <name>A1RYU4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_0974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0974"/>
    <dbReference type="EnsemblBacteria" id="ABL78374">
        <property type="protein sequence ID" value="ABL78374"/>
        <property type="gene ID" value="Tpen_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_0974"/>
    <dbReference type="eggNOG" id="arCOG02102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_12_0_2"/>
    <dbReference type="OMA" id="RHIMDMG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="106" mass="11396" checksum="693822EA74103BF5" modified="2007-02-06" version="1">MQKKLSELKPGEKGIVTRVEGPSAVRKRLLDMGLVKGTEVVVIRRAPLGDPIELLVKGYNLSIRKAESDYVYVLVPGDPEELTSSFASGAGDAPGSYSTGNVPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYW3</accession>
    <name>A1RYW3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_0993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752658.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_0993"/>
    <dbReference type="EnsemblBacteria" id="ABL78393">
        <property type="protein sequence ID" value="ABL78393"/>
        <property type="gene ID" value="Tpen_0993"/>
    </dbReference>
    <dbReference type="GeneID" id="4601969"/>
    <dbReference type="KEGG" id="tpe:Tpen_0993"/>
    <dbReference type="eggNOG" id="arCOG05506">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691625_0_0_2"/>
    <dbReference type="OMA" id="EVGHDTG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="155" mass="17210" checksum="4846D3D0F7C8F5FE" modified="2007-02-06" version="1">MSRETLHDFTVEYVKILAEVFGWSVKASPGQARGPDVVIEHSSGGKVDAVMFVEIEVGHDTGGAARYFGALCSRLEGLVEEYRSRYGDVAFTVVVVTNAPRRLSNGLRKEATRREFERRLGFEPVEGRNVFIVPVLLAREVLPAIFVKALGTREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A1RYZ2</accession>
    <name>A1RYZ2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752687.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1022"/>
    <dbReference type="EnsemblBacteria" id="ABL78422">
        <property type="protein sequence ID" value="ABL78422"/>
        <property type="gene ID" value="Tpen_1022"/>
    </dbReference>
    <dbReference type="GeneID" id="4601637"/>
    <dbReference type="KEGG" id="tpe:Tpen_1022"/>
    <dbReference type="eggNOG" id="arCOG14863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544274_0_0_2"/>
    <dbReference type="OrthoDB" id="121967at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="156" mass="17790" checksum="6A3B57D4530EE2E1" modified="2007-02-06" version="1">MREYRLLSRALARFERALVSGEPRVAVTRVSSRLAPGRGLGREHGLEYHSRLWGDLDWVLELEEAWTPLPLAWRFRFGWLVGVADLVRFVKARPVAVYEVKSYDTVKRAERVQAALYGLLVELNFATKPSVRLKTPSGEVEVKDWEALALDALRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ27</accession>
    <name>A1RZ27_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752722.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1057"/>
    <dbReference type="EnsemblBacteria" id="ABL78457">
        <property type="protein sequence ID" value="ABL78457"/>
        <property type="gene ID" value="Tpen_1057"/>
    </dbReference>
    <dbReference type="GeneID" id="4601443"/>
    <dbReference type="KEGG" id="tpe:Tpen_1057"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="LFWVYIA"/>
    <dbReference type="OrthoDB" id="57718at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="304" mass="33709" checksum="518F2D91AE222B86" modified="2007-02-06" version="1">MAKAHSLAQRIALLVLVAVLSYAIVYPVTWVVLTSLRKFGASLPTEKISLLDALFPKPDSLPSSIEETTYYMLLFKTKFPLFMWNSVYVSTLTMLLAVLVGTMSGYAFSRYNFPGKRKLLWTLLVLNSIPGLVTFIPLYRLLVFYDQTFRAIGLPKGTFLGPGGLILVYLAGAIPYSSWFLKSFFDTIPRELDEQALVDGATPFQIFWKITLPLALPGIATIAILVFLGAWNEFMLATLLLSNENYYTLPVFITQLRNQQYASTYGGIPAFAAASFMASIPVVILFVVSQKYLKSGLTMGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ48</accession>
    <name>A1RZ48_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase, B subunit</fullName>
            <ecNumber evidence="3">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1079"/>
    <dbReference type="EnsemblBacteria" id="ABL78478">
        <property type="protein sequence ID" value="ABL78478"/>
        <property type="gene ID" value="Tpen_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1079"/>
    <dbReference type="eggNOG" id="arCOG01554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="AGWVRKS"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="51"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19237" checksum="3740C39A0E095763" modified="2007-02-06" version="1">MSCPLGFVMVGRLEESARKAAQWLVEKTPIRSLRDWAITFSLWPVHFTTSCCGAEFAATSAPRFDAERFGFLPFNSPRQTNLMVIEGTLTKKMGEAAKIVYDQMPWPKFVIAMGACAIDGGLFYNSYNIVRPKDILPVEYFIPGCPPRPEAVAQAIIMLQEKVRKGEWRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ72</accession>
    <name>A1RZ72_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1103"/>
    <dbReference type="EnsemblBacteria" id="ABL78502">
        <property type="protein sequence ID" value="ABL78502"/>
        <property type="gene ID" value="Tpen_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1103"/>
    <dbReference type="eggNOG" id="arCOG07678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105257_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="251" mass="26754" checksum="A3E90E22481E9340" modified="2007-02-06" version="1">MHIVTFVFATAVAYVLAVVSSLIFPVLGAPGVSALYVAAAVYVPLGVWMGAWGALAGYFSCFFLGLYPSGYTVVQSLVWSFADFLEAIVPAFLFRALRVDPDFTVKRGWAAKLFPVLISLGSIVLLLGIVVQVLWGSLGEPFTSIYVYSVYTGLALAVLGLLVGLAVGNAKTWATYIVGVVLTSFISGLWGAGTLTLFNFPPPLPAAAFWPVFVGWVVGDLIVLSVLSTALLVALTPVFKRTGLYVEGWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZ96</accession>
    <name>A1RZ96_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">Tpen_1128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752791.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1128"/>
    <dbReference type="EnsemblBacteria" id="ABL78526">
        <property type="protein sequence ID" value="ABL78526"/>
        <property type="gene ID" value="Tpen_1128"/>
    </dbReference>
    <dbReference type="GeneID" id="4602023"/>
    <dbReference type="KEGG" id="tpe:Tpen_1128"/>
    <dbReference type="eggNOG" id="arCOG00024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_2"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="25345at2157"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="278"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="428"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABL78526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="523" mass="57892" checksum="D02362088ED21447" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZA1</accession>
    <name>A1RZA1_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752796.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1133"/>
    <dbReference type="EnsemblBacteria" id="ABL78531">
        <property type="protein sequence ID" value="ABL78531"/>
        <property type="gene ID" value="Tpen_1133"/>
    </dbReference>
    <dbReference type="GeneID" id="4601388"/>
    <dbReference type="KEGG" id="tpe:Tpen_1133"/>
    <dbReference type="eggNOG" id="arCOG02295">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178098_0_0_2"/>
    <dbReference type="OrthoDB" id="106684at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="237" mass="26740" checksum="1D3EDEBBC2840501" modified="2007-02-06" version="1">MSGLEKVLAEVKVFSFDVDGTLLDSYTYMRDVLQILLLYIGVPAGMLEMVTDDVYRSWYDLEKRGVFDYGKMHLFLEEFARKYAVPVRYDVKEFQDLLLEARVKGSEPYRCAVKLLSELKKRGKIVVSVSGGDGVPGMKRRRIEEGVPVKLFDKILVVPEDAPSRVEALNAVREEFGVSNEEVLHVDDRPQHAAEAYSAGFKAMVVKTGFYDPYFRLPDGVLVVDDLCAVLDALSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB5</accession>
    <name>A1RZB5_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Tpen_1147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752810.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1147"/>
    <dbReference type="EnsemblBacteria" id="ABL78545">
        <property type="protein sequence ID" value="ABL78545"/>
        <property type="gene ID" value="Tpen_1147"/>
    </dbReference>
    <dbReference type="GeneID" id="4600953"/>
    <dbReference type="KEGG" id="tpe:Tpen_1147"/>
    <dbReference type="eggNOG" id="arCOG00081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_2_0_2"/>
    <dbReference type="OMA" id="EMSHPGA"/>
    <dbReference type="OrthoDB" id="116151at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABL78545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="229" mass="24650" checksum="1F368FF465C3F7A5" modified="2007-02-06" version="1">MRDLLGLAERKKSRLILALDFVSGDPAVFADRLLAALEPLVVGVKVGLPLALRMGFRGVCELVERYGSGYYFLADFKLADIPDVVREELALLSEAGFDGSIVHLFPMGLEEALSGVRGHDVFGLVAMSHAGSRLLDEHFEDLLRYASRLGIRGVVAPATKPGLVARARAFLPEDYLILSPGVGAQGAEPGSALRHGATFEIVGRSITASEDYYGAAERVVESQRRVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZB9</accession>
    <name>A1RZB9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752814.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1151"/>
    <dbReference type="EnsemblBacteria" id="ABL78549">
        <property type="protein sequence ID" value="ABL78549"/>
        <property type="gene ID" value="Tpen_1151"/>
    </dbReference>
    <dbReference type="GeneID" id="4600957"/>
    <dbReference type="KEGG" id="tpe:Tpen_1151"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_2"/>
    <dbReference type="OMA" id="NPDYGSI"/>
    <dbReference type="OrthoDB" id="42250at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="314" mass="35192" checksum="76BEFFF760ADA9BD" modified="2007-02-06" version="1">MFFLSKRLKPEHVAFILLTIYPLTLNFVFGYFSMIFAFALSFFDWDILSPMKFVGLENYAKLAGELVQGFSIMLTDPRLVYLKTPFFNGLRNVLLYTLLVVPTQTLLALVLAVLANQKVRGSHFFRVAYFLPATTCPVIVSLIFIWLFMRDGFVNYFVSAVTGGFRPDWLNDPLFLLPAIAIVAIWGTSAHFSATFLAGLQALPKEVYEAARIDGANALKRFIYITIPLMKPLIVYAVVLGSIGALQMFDLAWVMAGQSGGPGGAGYTVALDIYNTAFLQLRYGYAAAKAVLLFLIVFSLNYYIQEKMKYFRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZC3</accession>
    <name>A1RZC3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kojibiose phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.230</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Tpen_1155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.230" evidence="4"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752818.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1155"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABL78553">
        <property type="protein sequence ID" value="ABL78553"/>
        <property type="gene ID" value="Tpen_1155"/>
    </dbReference>
    <dbReference type="GeneID" id="4602157"/>
    <dbReference type="KEGG" id="tpe:Tpen_1155"/>
    <dbReference type="eggNOG" id="arCOG07158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_1_2"/>
    <dbReference type="OMA" id="EAYCIPF"/>
    <dbReference type="OrthoDB" id="29128at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033831">
        <property type="term" value="F:kojibiose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="2">
        <location>
            <begin position="284"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABL78553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="704" mass="78513" checksum="1395F08C80AD00BE" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZD4</accession>
    <name>A1RZD4_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6379 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752829.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1166"/>
    <dbReference type="EnsemblBacteria" id="ABL78564">
        <property type="protein sequence ID" value="ABL78564"/>
        <property type="gene ID" value="Tpen_1166"/>
    </dbReference>
    <dbReference type="GeneID" id="4601180"/>
    <dbReference type="KEGG" id="tpe:Tpen_1166"/>
    <dbReference type="eggNOG" id="arCOG05512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044534_0_0_2"/>
    <dbReference type="OrthoDB" id="126075at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045959">
        <property type="entry name" value="DUF6379"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19906">
        <property type="entry name" value="DUF6379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6379" evidence="1">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="120" mass="13010" checksum="2A94BA02A711FBDD" modified="2007-02-06" version="1">MAFLPRALLKRLYVKGSMKLEHGYLSFKLKNSLATASLNAPVKVKVDDAEVKPEEVVIVVSGRTLKSSEISEANPVEVPVGTEVEVRIPGSYAPGKHKVALEISVKGYGRGSFEVEDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZE7</accession>
    <name>A1RZE7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1,4-Dihydroxy-2-naphtoate prenyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752842.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1179"/>
    <dbReference type="EnsemblBacteria" id="ABL78577">
        <property type="protein sequence ID" value="ABL78577"/>
        <property type="gene ID" value="Tpen_1179"/>
    </dbReference>
    <dbReference type="GeneID" id="4602045"/>
    <dbReference type="KEGG" id="tpe:Tpen_1179"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_1_2"/>
    <dbReference type="OMA" id="AWRSEDM"/>
    <dbReference type="OrthoDB" id="72417at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901663">
        <property type="term" value="P:quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="299" mass="31946" checksum="07F641011E8A44A5" modified="2007-02-06" version="1">MGFLRLVLRSLAHALEAARVWAVAMYAVYGLPVLILASKSPGFDAVMAVYGLAGGGLIEAWTHLVNDYFDFVHGVDLPGVSGTTVYRKHLLVEGYPRAKLLRLLVVLAGVVLLMAFVAAAVGRPYAVALAAAGLFLGYAYTGPPFTFKYRALGHVNLLAGWWLVNTPALYYMATGSFSAKPLLVSLPGILLVIAVLMGDNIRDLEVDRRAGVRTLEVILGKKPSRILFAVYVASAYAAQLALSLLLGAGMLLPLLSLPLLPSAVKAVMSDPPPPNTDPLVARLTLTFCALESLALWVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZF0</accession>
    <name>A1RZF0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752845.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1182"/>
    <dbReference type="EnsemblBacteria" id="ABL78580">
        <property type="protein sequence ID" value="ABL78580"/>
        <property type="gene ID" value="Tpen_1182"/>
    </dbReference>
    <dbReference type="GeneID" id="4600427"/>
    <dbReference type="KEGG" id="tpe:Tpen_1182"/>
    <dbReference type="eggNOG" id="arCOG02106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156342_0_0_2"/>
    <dbReference type="OrthoDB" id="86612at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="143" mass="16674" checksum="DF94E79D2E839763" modified="2007-02-06" version="1">MSKLRILEEKLRRPRFIPWDARREIIARIAQLLMDRPEVLIAVVHGGFISSDIFRDIDIAVYLGHKLPFMDTVFYVDRLRDRLQEALKIDIALDVQLLDYAPPAFTYRILSSGQIIVERMPGLASILKIRALEDLEKLRKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZN7</accession>
    <name>A1RZN7_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011752932.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1269"/>
    <dbReference type="EnsemblBacteria" id="ABL78667">
        <property type="protein sequence ID" value="ABL78667"/>
        <property type="gene ID" value="Tpen_1269"/>
    </dbReference>
    <dbReference type="GeneID" id="4600484"/>
    <dbReference type="KEGG" id="tpe:Tpen_1269"/>
    <dbReference type="eggNOG" id="arCOG03280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009384_0_0_2"/>
    <dbReference type="OMA" id="TWDDERT"/>
    <dbReference type="OrthoDB" id="3358at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="292"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="1113" mass="122981" checksum="D156997DB43750E7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW0</accession>
    <name>A1RZW0_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation ATPases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753005.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1343"/>
    <dbReference type="EnsemblBacteria" id="ABL78740">
        <property type="protein sequence ID" value="ABL78740"/>
        <property type="gene ID" value="Tpen_1343"/>
    </dbReference>
    <dbReference type="GeneID" id="4600867"/>
    <dbReference type="KEGG" id="tpe:Tpen_1343"/>
    <dbReference type="eggNOG" id="arCOG01425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778302_0_0_2"/>
    <dbReference type="OrthoDB" id="141347at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="321" mass="35360" checksum="1149F9EF4F702E09" modified="2007-02-06" version="1">MASSLKGEMLRLLREDEEFRYAVVGLLGLEDLRAELKGLREAVERLVEAHARAEERLSRLEAAVAGLGEAVSRHSEAIARLEVAVARHDEAVARLEAAVARLAEAQAKSEERLARLEEAVARQSESIAKLEAAVSKHSEVIARLEAAVAKHDETIARLEKAVAKHDESIARLEKAIARHDEAIARLEEAVRGLAAQVGRLSEAIGFGLEDVAALMVPGWLYRHLGVEVELGRGVVRVDGEEVEVDLYGEGTREGRRVLVVGEVKARIYRDDVDKFYQRVYARLAGREAGEVLGVLFGFFVHPAADERARELGLYALAPYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZW9</accession>
    <name>A1RZW9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753014.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1352"/>
    <dbReference type="EnsemblBacteria" id="ABL78749">
        <property type="protein sequence ID" value="ABL78749"/>
        <property type="gene ID" value="Tpen_1352"/>
    </dbReference>
    <dbReference type="GeneID" id="4602189"/>
    <dbReference type="KEGG" id="tpe:Tpen_1352"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334246_0_0_2"/>
    <dbReference type="OMA" id="VEARMIM"/>
    <dbReference type="OrthoDB" id="6553at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="85"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="293"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL78749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="854" mass="94999" checksum="2ECD126197202DB7" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY3</accession>
    <name>A1RZY3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753028.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1366"/>
    <dbReference type="EnsemblBacteria" id="ABL78763">
        <property type="protein sequence ID" value="ABL78763"/>
        <property type="gene ID" value="Tpen_1366"/>
    </dbReference>
    <dbReference type="GeneID" id="4601191"/>
    <dbReference type="KEGG" id="tpe:Tpen_1366"/>
    <dbReference type="eggNOG" id="arCOG06982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862274_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="322" mass="35249" checksum="8A50AE3C3B5B48B8" modified="2007-02-06" version="1">MKRGIKVKLSGERLRGVELVLEAGSVRAFTGFNATLKSASARAILLALLDLQLVTPLSEELLGDRLEGARGLVAAEVEGVEGGVLGYVVEDYRLVLRAYLQSVKDKLEELRGEVRRLEPPTGGIASEAYRLIREVEWLLSGSRDVLKLKESVDTKLLSRAERLVEEVLGRVAERAGVRVEDVAPLHLTVTGEGFIVRDERLGSEVQVESVSSAVSSALLWELTKLFFSVPAAARFLVVEEPEEAMSPLQQVAYARALERLAKEMPGDNYAVVTTHSPYVAVALSAAPVYFRWDWDSKMYVAEESTLPPSFTLAELLLLKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A1RZY6</accession>
    <name>A1RZY6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1369"/>
    <dbReference type="EnsemblBacteria" id="ABL78766">
        <property type="protein sequence ID" value="ABL78766"/>
        <property type="gene ID" value="Tpen_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1369"/>
    <dbReference type="eggNOG" id="arCOG02431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107614_0_1_2"/>
    <dbReference type="OMA" id="FMAYAMG"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="181" mass="19249" checksum="5B9558C07EABEBB0" modified="2007-02-06" version="1">MPGFSLWVVSVLHIGVAAHSSGSDAERAWRFVSALPGGVRVLLGGYWGVMRDVAEAARRRGLTVVFFLPVDPPAEVPDDELFVRVDTGLDLRGRSVALVRSSDALAVLGGEVGTVVEAFLAYSYGKPVAVLRGTGLSSDALERAFPRGFDGRGSAPVVYVDTPEELAARVVELAASRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S008</accession>
    <name>A1S008_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753053.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1391"/>
    <dbReference type="EnsemblBacteria" id="ABL78788">
        <property type="protein sequence ID" value="ABL78788"/>
        <property type="gene ID" value="Tpen_1391"/>
    </dbReference>
    <dbReference type="GeneID" id="4600674"/>
    <dbReference type="KEGG" id="tpe:Tpen_1391"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_2"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="295" mass="31383" checksum="CCFF6E86B44B3AA8" modified="2007-02-06" version="1">MPRPSLIGVEVTVLVDDYAGFSRLLAEHGFSVYLSLSYDDGSKYRVLFDTGRSGRVLLENASSLRLSLEEVDAVVLSHRHYDHAGGLPALLEKAGFKPVVAHPDVVKPSYADSGGFKRFSVALPAKAWEEVAGGSELVLTRAPLELAPGAWFLGEVERIYDNSYAVKGFYTLSGGEVVEDKLLDDTGLAVRVGDKALLVAGCSHSGISNLVRKALLVTGARTVTVIGGLHLAGATAEEVERVVSELSSLGVEEIHAGHCTGLRGEAALLKAFGGRAHRIHSGYRLALPGKAEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>A1S014</accession>
    <name>A1S014_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase, beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753059.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1397"/>
    <dbReference type="EnsemblBacteria" id="ABL78794">
        <property type="protein sequence ID" value="ABL78794"/>
        <property type="gene ID" value="Tpen_1397"/>
    </dbReference>
    <dbReference type="GeneID" id="4600461"/>
    <dbReference type="KEGG" id="tpe:Tpen_1397"/>
    <dbReference type="eggNOG" id="arCOG01203">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131320_0_0_2"/>
    <dbReference type="OMA" id="AWYWVLK"/>
    <dbReference type="OrthoDB" id="85273at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="171" mass="19659" checksum="A7F8AF753AB3510D" modified="2007-02-06" version="1">MKFGVEHIPEPYRALVVGLLESLLRLYGGSLVSLVVYGSVARGSPRRDSDLDLLVVFEDLPKSRVERVRLFERAEDEVQPLLDELMEKGYYVSLSPVIKTREEAGRFSPLYLDMVEDAVIVYDKGGFFEGVLRALSERLRRLGARRVWVSGRAWYWVLKGEYRFGEVVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S018</accession>
    <name>A1S018_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1401"/>
    <dbReference type="EnsemblBacteria" id="ABL78798">
        <property type="protein sequence ID" value="ABL78798"/>
        <property type="gene ID" value="Tpen_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1401"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_1_3_2"/>
    <dbReference type="OMA" id="MGPPPWA"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="141" mass="16109" checksum="77FE3CC47E51DA5E" modified="2007-02-06" version="1">MASFARNPLRIMVLSLLRKRPMSGVEIIEEIEEITLGFWRPSPGAVYPTLRALEEEGLVRREEEGWRKVYYLTEKGRMELEKLGLASQPAGIDDALCILEGYVEYLREVASRDGLSDEQVSRIERIAEDLRRLASSRAKPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>A1S066</accession>
    <name>DGGGP_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Digeranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="1">DGGGP synthase</shortName>
            <shortName evidence="1">DGGGPS</shortName>
            <ecNumber evidence="1">2.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Tpen_1449</name>
    </gene>
    <organism>
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18109"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="EC" id="2.5.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753111.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1S066"/>
    <dbReference type="SMR" id="A1S066"/>
    <dbReference type="STRING" id="368408.Tpen_1449"/>
    <dbReference type="EnsemblBacteria" id="ABL78846">
        <property type="protein sequence ID" value="ABL78846"/>
        <property type="gene ID" value="Tpen_1449"/>
    </dbReference>
    <dbReference type="GeneID" id="4601158"/>
    <dbReference type="KEGG" id="tpe:Tpen_1449"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073311_1_1_2"/>
    <dbReference type="OMA" id="WFYSHKL"/>
    <dbReference type="OrthoDB" id="104789at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01286">
        <property type="entry name" value="DGGGP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023547">
        <property type="entry name" value="DGGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000350721" description="Digeranylgeranylglyceryl phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01286"/>
        </source>
    </evidence>
    <sequence length="284" mass="29311" checksum="39666C660C418F25" modified="2007-02-06" version="1">MKSSLPGALFQRVADWLRLLRAGNCAVVSLGAYTGYVAGRGGSLPQGVLVAASAALVAAWGNIVNDYFDLESDAISKPWRPLPSRRISPGSAVSASLPLLAAGLALGFLVSPLCGFTAVLASALLFLYSWRVKALGLPGNVLIAFLAALNVVYGALASPEPWRSLLPSAYAFLIILGREVLKGVEDLEGDAARGVKTVASTLGARAALRVSAVLLLAVVALSPLPLLSGYGALYALFAFGGVDAPIALALLKAGPEPRRAWIATRILKVPLLMGLLAFLVGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A2</accession>
    <name>A1S0A2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753147.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1485"/>
    <dbReference type="EnsemblBacteria" id="ABL78882">
        <property type="protein sequence ID" value="ABL78882"/>
        <property type="gene ID" value="Tpen_1485"/>
    </dbReference>
    <dbReference type="GeneID" id="4601280"/>
    <dbReference type="KEGG" id="tpe:Tpen_1485"/>
    <dbReference type="eggNOG" id="arCOG00227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040513_0_0_2"/>
    <dbReference type="OrthoDB" id="28853at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="470" mass="51573" checksum="F739F59BADA0C754" modified="2007-02-06" version="1">MNKKLLGFGILTILVLAVVSVASASVQTPPLNVETQQYENTLVLITPSNTLLLKAVTTAFKNYAKNKLGVDVDVKLIQAGSPECMNRIIAWNGKPEADIFFGGDLIYHWKLKEKGLLESYKPKSPGYDAIPSTFLGFPLKDPDEMWHPKLWWGHGFMYNTKVLEKLGLQPPKTWDDLLDPKWKDLIVMCTPSRSSSTYINVGIIIQNRGWDQGWAFWRRLAANVGAFVQRSADVVDLVSKGEYAVGFAYSQGAIINRYNGYPVSMYMDPTGFIVSGVSLLKGAPHPNIAKAFLDWWYTEDAQQAALSAGGIPVLPTVKIAGPPNSTAAILREYLGGKDTIYDYLKTFTNVKFYNFTFAEAMYTNISKIFDNTIVAKHSELKDAWSTILSVQAKVKGVPDAEAKLAQAISAFDKGDYATAKALALEAAKIAETAPKGPSATEILVYAVIALVVIAALAYLLRGKLGKKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0A3</accession>
    <name>A1S0A3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753148.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1486"/>
    <dbReference type="EnsemblBacteria" id="ABL78883">
        <property type="protein sequence ID" value="ABL78883"/>
        <property type="gene ID" value="Tpen_1486"/>
    </dbReference>
    <dbReference type="GeneID" id="4601281"/>
    <dbReference type="KEGG" id="tpe:Tpen_1486"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="VYYKPKY"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL78883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="358" mass="39879" checksum="2E0A9E915E8E62D0" modified="2007-02-06" version="1">MVSVKVEDVWMTFGKVEALRGVNLEVAEGELVTLLGPSGCGKTTLLRVISGLYRPTRGRVYFDSEDVTEKNPWERNVGLVFQDYALWPHLKVYDNIAYGLRLRKIPKDEIDERVHRVASLLGIEDLLDRYPHQLSGGQQQRVALARAVVINPSVLLLDEPLSNLDAKIRINVRTEIRKLQKELKITSIYVTHDQEEALVISDRIAVMNKGFIEQVGSPLDIYYRPRTLFVADFVGQVNIVKGKVAEVAPDTGELVVESEIGELHVSADEKASKGEEVYLAFRPENVEILRAPRGGSAGLLEGRVDSVQFLGSLLRVDVEVGGKRIRAEIHNPARAGLFSPGEKVYLRVDPGNIRVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0E9</accession>
    <name>A1S0E9_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Tpen_1533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1533"/>
    <dbReference type="EnsemblBacteria" id="ABL78929">
        <property type="protein sequence ID" value="ABL78929"/>
        <property type="gene ID" value="Tpen_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1533"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_2"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="66"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="292"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABL78929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="452" mass="48619" checksum="34559159B2598988" modified="2007-02-06" version="1">MLALRVAFVYSVHMRETFFATGSECWKRMFDAKPLIGAGVLVYLTVALVARSRRPKTPVWSIMAFASFIVVATGLLGIDDVRKSVDVDVILFLVGMFSIVGLAETSGLLTAASYFFVSRFHSRVKLFYASAVLFGLLAAFAVNDTVALMGPAVAYVISRAAGIDPKAMFLLLAFSITIGSAMTPIGNPQNVLIASGSGMPAPMLVFTARLAVPTLVNLLLTAYLLSKLYGLRDAKVQVALIPEEAIRNRRDAALAAAGLAGTVLALVVNDFLELAGMPHVSDRGIIPFVAAAAIYPFTSNPRRILSRVDWSTVVFFITMFITVAGVMRSGVVDPALRLLLPEKATGARDLFAIALLSLALSQFLSNVPLASIMVEYMRGLGYSSTDVRAWLTLATASTIAGNLTLLGAASNIIILEMLERRFKTTITFTEFLRVGVLVTALNMLVYAPFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0H3</accession>
    <name>A1S0H3_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1558"/>
    <dbReference type="EnsemblBacteria" id="ABL78953">
        <property type="protein sequence ID" value="ABL78953"/>
        <property type="gene ID" value="Tpen_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1558"/>
    <dbReference type="eggNOG" id="arCOG00139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1032978_0_0_2"/>
    <dbReference type="OMA" id="HAYREHT"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL78953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="269" mass="28293" checksum="C5FAD537FE75F204" modified="2007-02-06" version="1">MKDALVWHMLLPEASAAISYPLLGYALSALRPGSVREGFLALAVAHVALAIYVLALFYPVTLKEGEEGSLLDDLRKLAGALGGRLRLYLSVELLYLLAWQLTPAFVLVNYVVEGYGGNLFHVALFDASMSTASVASMLVVDRVPARLGFRAMALSAAGVSASMLLLSAKPPLWALMVLGFALRMFDSAFLVFSRAWLYGSIAREEAALVSSGLSALSLTVLLAVPLLAGLLAAVSPGLPYLAGSFLVAATLPLIAEASKSAGQARPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0K4</accession>
    <name>A1S0K4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL78984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753249.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1589"/>
    <dbReference type="EnsemblBacteria" id="ABL78984">
        <property type="protein sequence ID" value="ABL78984"/>
        <property type="gene ID" value="Tpen_1589"/>
    </dbReference>
    <dbReference type="GeneID" id="4600553"/>
    <dbReference type="KEGG" id="tpe:Tpen_1589"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="OMA" id="YKIVYFF"/>
    <dbReference type="OrthoDB" id="42250at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL78984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="297" mass="31841" checksum="30E4334F19ECDAAE" modified="2007-02-06" version="1">MKNASTKDLLVFLGIPLSVILVFVVYPIVATVVLSFTADGALSAKNYVEVLTESIPLKALLVANPGPYPPWGALVHNALWIVIAVPAVVFLGMLLAYTLRGVPGSSFIAGAIFLGMVLPGVVSGLIIRFMFDDSLGIFPRIFGALGVPLLSKTWTIYPQTALLALILGSVWLWLGFSVTLYLAGLDSIPSSMVEAALVDGASQWEIFTRIIVPQLKPITVVVTLMTVMWILKIFDIVYVVTGGGPGGSSTVLALIMYTYFASSLEYGKAAAVAVILALLTLVPAYWYIRMILSGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0P2</accession>
    <name>A1S0P2_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protoglobin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1627"/>
    <dbReference type="EnsemblBacteria" id="ABL79022">
        <property type="protein sequence ID" value="ABL79022"/>
        <property type="gene ID" value="Tpen_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1627"/>
    <dbReference type="HOGENOM" id="CLU_1340788_0_0_2"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Protoglobin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="204" mass="22848" checksum="BE65EC2A3DA10769" modified="2007-02-06" version="1">MRGLLDSVKRSIVEYAESWSQRSRKVVGISEADIELLRSSWSDANALIDGVVEGFLGRVYEDEEVARLIKEGALSLEELREFCKSHLILVFNGNYDRAHGLWLFWVGLRNLSRGVPVRLDMEFLGFALSELLTRFDDRVKVSLVKAFMWTASVFASAYYASAALSFYLATGVRRELSERLIRQAAEELGRSVEEAISSGSGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0S0</accession>
    <name>A1S0S0_THEPD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753315.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1655"/>
    <dbReference type="EnsemblBacteria" id="ABL79050">
        <property type="protein sequence ID" value="ABL79050"/>
        <property type="gene ID" value="Tpen_1655"/>
    </dbReference>
    <dbReference type="GeneID" id="4601732"/>
    <dbReference type="KEGG" id="tpe:Tpen_1655"/>
    <dbReference type="eggNOG" id="arCOG03349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141525_1_0_2"/>
    <dbReference type="OMA" id="MPEFANP"/>
    <dbReference type="OrthoDB" id="32827at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="96" mass="10954" checksum="6C29172537A82FB9" modified="2007-02-06" version="1">MLAKNPLEVPPGRKFSKEELAQAVRLSIIAELDAVNLYLQLANATDDPLARKVFEDIAREEKTHVGEFLSLLERLDPEQVKELEKGKKEVLELEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0T4</accession>
    <name>A1S0T4_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753329.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1669"/>
    <dbReference type="EnsemblBacteria" id="ABL79064">
        <property type="protein sequence ID" value="ABL79064"/>
        <property type="gene ID" value="Tpen_1669"/>
    </dbReference>
    <dbReference type="GeneID" id="4601251"/>
    <dbReference type="KEGG" id="tpe:Tpen_1669"/>
    <dbReference type="eggNOG" id="arCOG04046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648366_0_0_2"/>
    <dbReference type="OMA" id="GTLWDHE"/>
    <dbReference type="OrthoDB" id="97545at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="169" mass="18971" checksum="ABAB5917E47A4623" modified="2007-02-06" version="1">MGIKALVVDLDGTLWSHRDISRTRPPFRRVSDGVVVDSTGQEVRLNPCVEEALRAAREAGLRLAVASWNDPEPAVEALKALGVYGYFDLLVIEPHPGKDRMLEKILRELRLSPGEVVFVDDTEYMVELVREAHPGILSLRMGVDVRDFCELLRKLNIFTTQGFRSRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U2</accession>
    <name>A1S0U2_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753337.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1677"/>
    <dbReference type="EnsemblBacteria" id="ABL79072">
        <property type="protein sequence ID" value="ABL79072"/>
        <property type="gene ID" value="Tpen_1677"/>
    </dbReference>
    <dbReference type="GeneID" id="4600929"/>
    <dbReference type="KEGG" id="tpe:Tpen_1677"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OMA" id="MLGMRNM"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="117"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="347" mass="39144" checksum="514380837C1E0EB3" modified="2007-02-06" version="1">MTSKILQGHRVNSGLLNYFLKRLFILLLSFFLIVTINWLIPRMAPGNPVDVLISRMGLTGLQASAEQMRSYFLKAFALDKPLWEQYINFWLGLFQGDLGISVYRFPTPVSEIIMEAIPYTVAPVAPALLVSWYIGNKLGALAAKKRLLDNILVPLAYYLANAPYFWLGVVLQFVFSVELCKSTPICLPSGFPYSRGLTPSLNVTFLWDAFMHWILPFASYVLVQMGGWMIGMRNMIIYELGSNYAKYMEDLGFSDSMLSKYVYRHALLPQVTGLGIQIGMLVSLGVAVEFVFSYPGLGYYLVNAIQNRDYFLTQGIVLVVTISVLVANFIIDILYGVLDPRTRLTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0U8</accession>
    <name>A1S0U8_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753343.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1683"/>
    <dbReference type="EnsemblBacteria" id="ABL79078">
        <property type="protein sequence ID" value="ABL79078"/>
        <property type="gene ID" value="Tpen_1683"/>
    </dbReference>
    <dbReference type="GeneID" id="4600571"/>
    <dbReference type="KEGG" id="tpe:Tpen_1683"/>
    <dbReference type="eggNOG" id="arCOG02682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_2"/>
    <dbReference type="OMA" id="EIFPTKD"/>
    <dbReference type="OrthoDB" id="38526at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="5"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="415" mass="44067" checksum="FB8137D65A5A05C4" modified="2007-02-06" version="1">MKSRLLPVLMAGWAIGAMYAGVVSGTLTLIRAELAMGAEEAGRVLSSWLLGMLLGASLIGYLSDRVGRRASLVASYALMGVFTPMSAAARGWLDLSVYRVLAGAGNAGYMVTASVLLAEYAPTSSRGRQVAVLESAWALGWLASLVLSRLIAPSYGWRAVFLASSAALALLPVLYVAVPESLRFLVSKGRLAEAEALAGRLGVEVPRAQPAARAGLRDLVGRRYLRRSVMLWIHWFMLVLAYWGIFLWLPDILYKRGIPFVRSLDYAILITLAQIPGYLSGAYLVEVAGRKPVLAAYMLGAGIASAGLWAAKTDLEALAWGVLVSFFNLGAWGVTYAYTPELYPTELRGTGSGWANAFGRIGGILGPYVAGVMIQSYGNPSAPFAVFALAHVVSAAVVAALGVETKGRSLEEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A1S0Y6</accession>
    <name>A1S0Y6_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Tpen_1721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1721"/>
    <dbReference type="EnsemblBacteria" id="ABL79116">
        <property type="protein sequence ID" value="ABL79116"/>
        <property type="gene ID" value="Tpen_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1721"/>
    <dbReference type="eggNOG" id="arCOG01403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684468_0_0_2"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABL79116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="402" mass="45501" checksum="02C3DCA4CAC74159" modified="2007-02-06" version="1">MGSINKNKKTLLFISAIVGSTGDVINEWQVAMSLAKHARNVFIIAPVGLRYVISREYKKYLLDRPSNTRIILLPFALLPSDFLYLMNLIIFIFYSLMIYILTLTLDMMIHFDIIYVRDSRLALLLAFSPRLARKCFVKIAAILEDGIYQVLLRQLTLMLINSIDRHVLERTAGIITHSADFAKSLVLRKKVLPKRIIVIPPGIMLNTVKIVRRICRRKTKTENEVTVGFLGFLAPWQGVDMLCSIVAELNRLGYKAKLKVVGDGPLKRQLLKECTKLGVPVEITGFVSHPVALCIARRDFDVMVLPRVSTETTATIMPIKVIEALALGIPVVATELPVYESSAFREKGLYTSRRDPKAFAETIARILRESGSDTIKLPSFDLFKPYLYDYSVKRFIEYVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>A1S115</accession>
    <name>A1S115_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase associated with various cellular activities, AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Tpen_1750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753410.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1750"/>
    <dbReference type="EnsemblBacteria" id="ABL79145">
        <property type="protein sequence ID" value="ABL79145"/>
        <property type="gene ID" value="Tpen_1750"/>
    </dbReference>
    <dbReference type="GeneID" id="4601775"/>
    <dbReference type="KEGG" id="tpe:Tpen_1750"/>
    <dbReference type="eggNOG" id="arCOG00435">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_2"/>
    <dbReference type="OMA" id="DRFMFAI"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABL79145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="353" mass="39384" checksum="998996609B5CD9AC" modified="2007-02-06" version="1">MPVGVDDVKEVSRELLGELGRVVVGYEEEKALVLASLIAGGHVLLEGVPGIAKTTLAKSLARLLGLSEGYALELDGVAYRGFSRVQFTPDLMPSDITGNLVFNPSTRSFEPRFGPVFTYFLLADEINRAVPRTQSALLQAMQEREVTIGDRSYRLEVRERGKFFFVIATQNPVEQEGTYPLPEAQLDRFLMRVFVGYPSSLEEEVSIYRLHGYRVGEPYEDLERLVEPGWVVEAQDCVARSVEVPDEVFEYVARVVRLTRPSVYPEIAEYFELGASPRSGIALVKASKALAAMRGSTVVERVDVDRALFPVLNHRLVLNVEKLVSEEFRGEKAVAHIKVIREGLRKVVEVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>A1S120</accession>
    <name>A1S120_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753415.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1755"/>
    <dbReference type="EnsemblBacteria" id="ABL79150">
        <property type="protein sequence ID" value="ABL79150"/>
        <property type="gene ID" value="Tpen_1755"/>
    </dbReference>
    <dbReference type="GeneID" id="4601953"/>
    <dbReference type="KEGG" id="tpe:Tpen_1755"/>
    <dbReference type="eggNOG" id="arCOG02900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867726_0_0_2"/>
    <dbReference type="OMA" id="YNITALH"/>
    <dbReference type="OrthoDB" id="131574at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="91"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="305" mass="32600" checksum="3E292DAAB8C54333" modified="2007-02-06" version="1">MYLVFGKAYLLLLAPASLLAIYAVYRRAKRVQEGIRRALPGELPGLTPRLALASAIALLLVLAASEPRVVEVKRVELPLEEAYKLSGVPTLHVVVLDESKSMLSADVYPDRCTLAKRFAEKYIEGLQPSDLVVLVFFSSSSNATGPLPRDNALRALDGYTCRYRYTALGDALVSAYSVLAASGLPGAVVVVSDGGWNYGSDPLQVAQSIRASNYSLVLVRVGGDPRGSLMRDVASKANGKYLELDAFSQDLAPSIASNVSATARYEALRLAGLAYADVTVETPVGREPLLLLAALLAALLFRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>A1S171</accession>
    <name>A1S171_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753466.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1806"/>
    <dbReference type="EnsemblBacteria" id="ABL79201">
        <property type="protein sequence ID" value="ABL79201"/>
        <property type="gene ID" value="Tpen_1806"/>
    </dbReference>
    <dbReference type="GeneID" id="4601799"/>
    <dbReference type="KEGG" id="tpe:Tpen_1806"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="IHVMRFN"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="356" mass="40087" checksum="7327AA68C07E307F" modified="2007-02-06" version="1">MTRITLKGVTKVYGAVKAVDNVNLEINDGELFTILGPSGCGKTTTLRIIAGFEVPDEGRVYFDDEDVTFLKPYMRETAMVFQNYALWPHMTVFENVAYGLRIRKKQLRLTDEEIERRVKEALSLVRLEGLEDRYPLQLSGGQQQRVALARALVVQPKVLLLDEPLSNLDAKLRIEMREEIKRIQKSLGITTVYVTHDQLEAMSISDKIAVMDKGRVLQYGHPREVYFRPTNLFTAEFLGRSNIYKGEVVERGEGYVVVRVEELGIDVKAVPVAENLVGKVAVVVRPEVFTVGGQRGEPNTVKGTVDFVMFLGDRTEVRLKVGKASLIAYLPNTYYPQVGEELELSAPWRNVIAIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>A1S172</accession>
    <name>A1S172_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Tpen_1807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1807"/>
    <dbReference type="EnsemblBacteria" id="ABL79202">
        <property type="protein sequence ID" value="ABL79202"/>
        <property type="gene ID" value="Tpen_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="tpe:Tpen_1807"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_1_0_2"/>
    <dbReference type="OMA" id="AWRWVAL"/>
    <dbReference type="OrthoDB" id="32131at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="222"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="514"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABL79202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="732" mass="80065" checksum="69841C3C6CCBF10D" modified="2007-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>A1S188</accession>
    <name>A1S188_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Tpen_1823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753483.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1823"/>
    <dbReference type="EnsemblBacteria" id="ABL79218">
        <property type="protein sequence ID" value="ABL79218"/>
        <property type="gene ID" value="Tpen_1823"/>
    </dbReference>
    <dbReference type="GeneID" id="4602060"/>
    <dbReference type="KEGG" id="tpe:Tpen_1823"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_62_0_2"/>
    <dbReference type="OMA" id="VYAGMQI"/>
    <dbReference type="OrthoDB" id="87359at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABL79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="396" mass="41643" checksum="417B32B599DBBCCE" modified="2007-02-06" version="1">MERKLLYSITSLYVAYFLVYVHRTMTGVVQEELGGIASAHGLPPAAFTSIVAAAYFYTYAAMQLPAGILADALGAKRYVGTSMLLLGLGSALASTCDPTLILVGRLVIGVGAASVWVSLQRVIGVYAEKNVGATLTGLALAVGNLGALFATAPLREAVDAVGLRAVFLYLAVAAFILSVAAFLGINDPGISRGSLKRGLAETLRQLKVVARSRHSIALALAFAGTYSAVLAFQSLWASIYVSRYFPEYRRETPLLLLLLALAFLVSVPLVGYVSDAVLKKRKPVLLAGIVLHFLAWVGLLVASRLSLGLAELEAIFLLLGVVAATHMVIPPLSREAYSPEFSGTTLAFVNMVGFVAIAVYQSIGAVVGDPSIPLVVFALVSLAALLLSGSVRETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-06" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>A1S195</accession>
    <name>A1S195_THEPD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desulfoferrodoxin, ferrous iron-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Tpen_1830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Thermofilum pendens (strain DSM 2475 / Hrk 5)</name>
        <dbReference type="NCBI Taxonomy" id="368408"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Thermofilales</taxon>
            <taxon>Thermofilaceae</taxon>
            <taxon>Thermofilum</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="2957" last="2965">
            <title>Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction.</title>
            <authorList>
                <person name="Anderson I."/>
                <person name="Rodriguez J."/>
                <person name="Susanti D."/>
                <person name="Porat I."/>
                <person name="Reich C."/>
                <person name="Ulrich L.E."/>
                <person name="Elkins J.G."/>
                <person name="Mavromatis K."/>
                <person name="Lykidis A."/>
                <person name="Kim E."/>
                <person name="Thompson L.S."/>
                <person name="Nolan M."/>
                <person name="Land M."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Lucas S."/>
                <person name="Detter C."/>
                <person name="Zhulin I.B."/>
                <person name="Olsen G.J."/>
                <person name="Whitman W."/>
                <person name="Mukhopadhyay B."/>
                <person name="Bristow J."/>
                <person name="Kyrpides N."/>
            </authorList>
            <dbReference type="PubMed" id="18263724"/>
            <dbReference type="DOI" id="10.1128/JB.01949-07"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 2475 / Hrk 5</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000505">
        <property type="protein sequence ID" value="ABL79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011753490.1">
        <property type="nucleotide sequence ID" value="NC_008698.1"/>
    </dbReference>
    <dbReference type="STRING" id="368408.Tpen_1830"/>
    <dbReference type="EnsemblBacteria" id="ABL79225">
        <property type="protein sequence ID" value="ABL79225"/>
        <property type="gene ID" value="Tpen_1830"/>
    </dbReference>
    <dbReference type="GeneID" id="4602067"/>
    <dbReference type="KEGG" id="tpe:Tpen_1830"/>
    <dbReference type="eggNOG" id="arCOG02146">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_2_1_2"/>
    <dbReference type="OMA" id="RIHLEPE"/>
    <dbReference type="OrthoDB" id="106274at2157"/>
    <dbReference type="Proteomes" id="UP000000641">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABL79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000641"/>
        </source>
    </evidence>
    <sequence length="125" mass="14301" checksum="4749BFC453BBDCD4" modified="2007-02-06" version="1">MPKKFGDLIYTPETASGEAISKVETHTPRIEAPDSVKAGEPFYVKIYVGPHPNTLQHSIRWIEVYFEEEGRPFNPVMLSRIHLEPELVEPEVTLKLVLKKSGVIYALEYCNLHGVWEGRKQVKVQ</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>